DOWN- UP PATTERN Supplementary Fig.3. Talylor et al Gene Molecular Function Mutant Phenotype Arrestin 1 Deactivation of rhodopsin-mediated signaling, disrupts the interaction of Rhodopsin Light-dependent eye degeneration with the G-protein, transducin Deactivation of rhodopsin-mediated signaling, disrupts the interaction of Rhodopsin Arrestin 2 Light-dependent eye degeneration with the G-protein, transducin inaD Deactivation of rhodopsin-mediated signaling Light-dependent eye degeneration inaF Deactivation of rhodopsin-mediated signaling Defect. LAVG Ca2+ channel function inaC Deactivation of rhodopsin-mediated signaling, Diacylglycerol-binding protein kinase C Defect. Rhodopsin-mediated signaling Gb 76C Deactivation of rhodopsin-mediated signaling, b-subunit of heterotrimeric G-protein GTPase Light-dependent eye degeneration (Transducin) Gg 30A Heterotrimeric G-protein GTPase involved in rhodopsin-mediated signaling Unknown 2+ trp Light-activated voltage-gated Ca channel Defect. Rhod-mediated signaling, eye degen. trp-like Light-activated voltage-gated Ca2+ channel Defect. Rhod-mediated signaling, eye degen. ninaE Long-wave sensitive opsin in R1-R6, mediates G-protein-coupled signaling Defect. Rhod-mediated signaling, rhabdomere degen. Rhodopsin 3 UV-sensitive opsin in R7-8, mediates G-protein-coupled signaling Defect. Rhod-mediated signaling Rhodopsin 4 UV-sensitive opsin in R7, mediates G-protein-coupled signaling Defect. Rhodopsin-mediated signaling Rhodopsin 5 Blue-sensitive in R8, mediates G-protein-coupled signaling Defect. Rhod-mediated signaling Rab-RP1 Rab-like GTPase involved in intracellular signaling Unknown oxidoreductase Short-chain dehydrogenase/reductase, implicated in repulsive axon guidance Unknown CG4979 Phosphatidylserine-specific phospholipase A1 Unknown chaoptic Extracellular membrane glycoprotein, mediates homophilic photoreceptor cell adhesion Rhabdomeres highly deranged ninaC Deactivation of rhodopsin-mediated signaling, calmodulin-binding serine/threonine Defect. Rhod-mediated signaling, kinase reduced Rhodopsin levels. msta Unknown, expressed in photoreceptor cells Unknown PIP82 Unknown, expressed in photoreceptor cells Unknown CG13077 Unknown Unknown CG1561 Unknown Unknown CG4468 Unknown Unknown.