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Realtime Ready Human Apoptosis Panel

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For life science research only. FOR IN VITRO USE ONLY. Human Apoptosis Panel, 384 Ready-to-use panel for the gene expression profiling of apoptosis-related genes Cat. No. 05 339 316 001 2 plates, each containing 384 assays Version November 2008 N Store at +2 to +8°C N Store protected from light! Plate Layout 123456789101112131415161718192021222324 A 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 B 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 C 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 D 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 E 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 F 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 G 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 H 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 I 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 J 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 K 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 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chaperone regulator 1 5 A 05 AIFM1 Apoptosis-inducing factor 1, mitochondrial precursor 20 A 20 BAG3 BAG family molecular chaperone regulator 3 6 A 06 AIFM2 Apoptosis-inducing factor 2 21 A 21 BAG4 BAG family molecular chaperone regulator 4 7 A 07 AIFM3 Apoptosis-inducing factor 3 22 A 22 BAK1 Bcl-2 homologous antagonist/killer 8 A 08 AKT1 Proline-rich AKT1 substrate 1 23 A 23 BAX Apoptosis regulator BAX. 9 A 09 ALOX15B Arachidonate 15-lipoxygenase type II 24 A 24 BBC3 Bcl-2-binding component 3 10 A 10 ANXA1 Annexin A1 25 B 01 BCAP31 B-cell receptor-associated protein 31 11 A 11 ANXA4 Annexin A4 26 B 02 BCL10 B-cell lymphoma/leukemia 10 12 A 12 APAF1 Apoptotic protease-activating factor 1 27 B 03 BCL2 Apoptosis regulator Bcl-2. 13 A 13 API5 Apoptosis inhibitor 5 28 B 04 BCL2A1 Bcl-2-related protein A1 14 A 14 APOE Apolipoprotein E precursor 29 B 05 BCL2L1 Apoptosis regulator Bcl-X 15 A 15 ATF5 Cyclic AMP-dependent transcription factor ATF-5 30 B 06 BCL2L10 Apoptosis regulator Bcl-B www.roche-applied-science.com No. Pos HGNC- Description No. Pos HGNC- Description Symbol Symbol 31 B 07 BCL2L11 Bcl-2-like protein 11 84 D 12 CD38 ADP-ribosyl cyclase 1 32 B 08 BCL2L13 Bcl-2-like 13 protein 85 D 13 CD40 Tumor necrosis factor receptor superfamily member 5 precursor 33 B 09 BCL2L2 Apoptosis regulator Bcl-W 86 D 14 CD40LG CD40 ligand 34 B 10 BCL3 B-cell lymphoma 3-encoded protein 87 D 15 CD5 T-cell surface glycoprotein CD5 precursor 35 B 11 BCL6 B-cell lymphoma 6 protein 88 D 16 CD70 CD70 antigen 36 B 12 BCLAF1 Bcl-2-associated transcription factor 1 89 D 17 CDKN1A Cyclin-dependent kinase inhibitor 1 (p21) 37 B 13 BDNF Brain-derived neurotrophic factor precursor 90 D 18 CEBPB CCAAT/enhancer-binding protein beta 38 B 14 BECN1 Beclin-1 91 D 19 CEBPG CCAAT/enhancer-binding protein gamma 39 B 15 BFAR Bifunctional apoptosis regulator 92 D 20 CFDP1 Craniofacial development protein 1 40 B 16 BID BH3-interacting domain death agonist 93 D 21 CFL1 Cofilin-1 41 B 17 BIK Bcl-2-interacting killer 94 D 22 CFLAR CASP8 and FADD-like apoptosis regulator precursor 42 B 18 BIRC2 Baculoviral IAP repeat-containing protein 2 95 D 23 CHEK2 Serine/threonine-protein kinase Chk2 43 B 19 BIRC3 Baculoviral IAP repeat-containing protein 3 96 D 24 CHUK Inhibitor of nuclear factor kappa-B kinase subunit 44 B 20 BIRC5 Baculoviral IAP repeat-containing protein 5 alpha 45 B 21 BIRC6 Baculoviral IAP repeat-containing protein 6 97 E 01 CIDEA Cell death activator CIDE-A 46 B 22 BIRC7 Baculoviral IAP repeat-containing protein 7 98 E 02 CIDEB Cell death activator CIDE-B 47 B 23 BIRC8 Baculoviral IAP repeat-containing protein 8 99 E 03 CIDEC Cell death activator CIDE-3 48 B 24 BMF Bcl-2-modifying factor. 100 E 04 COL4A3 Collagen alpha-3 49 C 01 BNIP1 Vesicle transport protein SEC20 101 E 05 CRADD Death domain-containing protein CRADD 50 C 02 BNIP2 BCL2/adenovirus E1B 19 kDa protein-interacting pro- 102 E 06 CRYAA Alpha-crystallin A chain tein 2. 103 E 07 CRYAB Alpha-crystallin B chain 51 C 03 BNIP3 BCL2/adenovirus E1B 19 kDa protein-interacting pro- tein 3. 104 E 08 CUL1 Cullin-1 52 C 04 BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 105 E 09 CUL2 Cullin-2 53 C 05 BOK Bcl-2-related ovarian killer protein 106 E 10 CUL3 Cullin-3 54 C 06 BRAF B-Raf proto-oncogene serine/threonine-protein 107 E 11 CUL4A Cullin-4A kinase 108 E 12 CUL5 Cullin-5 55 C 07 BRCA1 Breast cancer type 1 susceptibility protein 109 E 13 CYCS Cytochrome c 56 C 08 BRE Protein BRE 110 E 14 DAD1 Dolichyl-diphosphooligosaccharide--protein glycosyl- 57 C 09 BTK Tyrosine-protein kinase BTK transferase subunit DAD1 58 C 10 CAD CAD protein 111 E 15 DAP Death-associated protein 1 59 C 11 CARD10 Caspase recruitment domain-containing protein 10 112 E 16 DAP3 Death associated protein 3 60 C 12 CARD11 Caspase recruitment domain-containing protein 11 113 E 17 DAPK1 Death-associated protein kinase 1. 61 C 13 CARD14 Caspase recruitment domain-containing protein 14 114 E 18 DAPK2 Death-associated protein kinase 2 62 C 14 CARD4 Nucleotide-binding oligomerization domain-contain- 115 E 19 DAPK3 Death-associated protein kinase 3 ing protein 1 116 E 20 DAXX Death domain-associated protein 6 63 C 15 CARD6 Caspase recruitment domain-containing protein 6. 117 E 21 DBP D site-binding protein 64 C 16 CARD8 Caspase recruitment domain-containing protein 8 118 E 22 DCC Netrin receptor DCC precursor 65 C 17 CARD9 Caspase recruitment domain-containing protein 9 119 E 23 DDAH2 dimethylarginine dimethylaminohydrolase 2 66 C 18 CASP1 Caspase-1 precursor 120 E 24 DDIT3 DNA damage-inducible transcript 3 67 C 19 CASP10 Caspase-10 precursor 121 F 01 DDX20 Probable ATP-dependent RNA helicase DDX20 68 C 20 CASP12 Inactive caspase-12 122 F 02 DEDD Death effector domain-containing protein 69 C 21 CASP14 Caspase-14 precursor 123 F 03 DEDD2 DNA-binding death effector domain-containing pro- 70 C 22 CASP2 Caspase-2 precursor tein 2 71 C 23 CASP3 Caspase-3 precursor 124 F 04 DFFA DNA fragmentation factor subunit alpha 72 C 24 CASP4 Caspase-4 precursor 125 F 05 DHCR24 24-dehydrocholesterol reductase precursor 73 D 01 CASP5 Caspase-5 precursor 126 F 06 DIABLO Diablo homolog, mitochondrial precursor 74 D 02 CASP6 Caspase-6 precursor 127 F 07 DPF2 Zinc finger protein ubi-d4 75 D 03 CASP7 Caspase-7 precursor 128 F 08 DYRK2 Dual specificity tyrosine-phosphorylation-regulated kinase 1A 76 D 04 CASP8 Caspase-8 precursor 129 F 09 EDA Ectodysplasin A 77 D 05 CASP8AP2 CASP8-associated protein 2 130 F 10 EDAR Ectodysplasin A receptor 78 D 06 CASP9 Caspase-9 precursor 131 F 11 EEF1A2 Elongation factor 1-alpha 2 79 D 07 CBX4 E3 SUMO-protein ligase CBX4 132 F 12 EIF2AK3 Eukaryotic translation initiation factor 2-alpha kinase 3 80 D 08 CCL2 C-C motif chemokine 2 precursor precursor 81 D 09 CD2 CD2 molecule 133 F 13 endoG Endonuclease G, mitochondrial precursor 82 D 10 CD27 CD27 antigen precursor 134 F 14 ERC1 ELKS/RAB6-interacting/CAST family member 1 83 D 11 CD28 T-cell-specific surface glycoprotein CD28 precursor 2 www.roche-applied-science.com No.
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  • Supplementary Materials

    Supplementary Materials

    Supplementary materials Supplementary Table S1: MGNC compound library Ingredien Molecule Caco- Mol ID MW AlogP OB (%) BBB DL FASA- HL t Name Name 2 shengdi MOL012254 campesterol 400.8 7.63 37.58 1.34 0.98 0.7 0.21 20.2 shengdi MOL000519 coniferin 314.4 3.16 31.11 0.42 -0.2 0.3 0.27 74.6 beta- shengdi MOL000359 414.8 8.08 36.91 1.32 0.99 0.8 0.23 20.2 sitosterol pachymic shengdi MOL000289 528.9 6.54 33.63 0.1 -0.6 0.8 0 9.27 acid Poricoic acid shengdi MOL000291 484.7 5.64 30.52 -0.08 -0.9 0.8 0 8.67 B Chrysanthem shengdi MOL004492 585 8.24 38.72 0.51 -1 0.6 0.3 17.5 axanthin 20- shengdi MOL011455 Hexadecano 418.6 1.91 32.7 -0.24 -0.4 0.7 0.29 104 ylingenol huanglian MOL001454 berberine 336.4 3.45 36.86 1.24 0.57 0.8 0.19 6.57 huanglian MOL013352 Obacunone 454.6 2.68 43.29 0.01 -0.4 0.8 0.31 -13 huanglian MOL002894 berberrubine 322.4 3.2 35.74 1.07 0.17 0.7 0.24 6.46 huanglian MOL002897 epiberberine 336.4 3.45 43.09 1.17 0.4 0.8 0.19 6.1 huanglian MOL002903 (R)-Canadine 339.4 3.4 55.37 1.04 0.57 0.8 0.2 6.41 huanglian MOL002904 Berlambine 351.4 2.49 36.68 0.97 0.17 0.8 0.28 7.33 Corchorosid huanglian MOL002907 404.6 1.34 105 -0.91 -1.3 0.8 0.29 6.68 e A_qt Magnogrand huanglian MOL000622 266.4 1.18 63.71 0.02 -0.2 0.2 0.3 3.17 iolide huanglian MOL000762 Palmidin A 510.5 4.52 35.36 -0.38 -1.5 0.7 0.39 33.2 huanglian MOL000785 palmatine 352.4 3.65 64.6 1.33 0.37 0.7 0.13 2.25 huanglian MOL000098 quercetin 302.3 1.5 46.43 0.05 -0.8 0.3 0.38 14.4 huanglian MOL001458 coptisine 320.3 3.25 30.67 1.21 0.32 0.9 0.26 9.33 huanglian MOL002668 Worenine