Delta-Notch Signaling: the Long and the Short of a Neuron’S Influence on Progenitor Fates
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Placement of Children with Relatives
STATE STATUTES Current Through January 2018 WHAT’S INSIDE Placement of Children With Giving preference to relatives for out-of-home Relatives placements When a child is removed from the home and placed Approving relative in out-of-home care, relatives are the preferred placements resource because this placement type maintains the child’s connections with his or her family. In fact, in Placement of siblings order for states to receive federal payments for foster care and adoption assistance, federal law under title Adoption by relatives IV-E of the Social Security Act requires that they Summaries of state laws “consider giving preference to an adult relative over a nonrelated caregiver when determining a placement for a child, provided that the relative caregiver meets all relevant state child protection standards.”1 Title To find statute information for a IV-E further requires all states2 operating a title particular state, IV-E program to exercise due diligence to identify go to and provide notice to all grandparents, all parents of a sibling of the child, where such parent has legal https://www.childwelfare. gov/topics/systemwide/ custody of the sibling, and other adult relatives of the laws-policies/state/. child (including any other adult relatives suggested by the parents) that (1) the child has been or is being removed from the custody of his or her parents, (2) the options the relative has to participate in the care and placement of the child, and (3) the requirements to become a foster parent to the child.3 1 42 U.S.C. -
Visualizing Morphogenesis with the Processing Programming Language 15
Visualizing Morphogenesis with the Processing Programming Language 15 Visualizing Morphogenesis with the Processing Programming Language Avik Patel, Amar Bains, Richard Millet, and Tamira Elul changing tissue shapes. A powerful technique for elucidating the We used Processing, a visual artists’ programming dynamic cellular mechanisms of morphogenesis is time-lapse video- language developed at MIT Media Lab, to simulate microscopic imaging of cells in embryonic tissues undergoing cellular mechanisms of morphogenesis – the generation morphogenesis (Elul and Keller 2000; Elul et al., 1997; Harris et al., of form and shape in embryonic tissues. Based on 1987). The mechanisms underlying morphogenetic processes can be clarified by observation of cell dynamics from these time-lapse video observations of in vivo time-lapse image sequences, we sequences. Morphometric measurement further defines the created animations of neural cell motility responsible for quantitative and statistical relationships between the cell dynamics that elongating the spinal cord, and of optic axon branching underlie morphogenesis (Kim and Davidson 2011; Marshak et al., dynamics that establish primary visual connectivity. 2007; Elul et al., 1997; Witte et al., 1996). Mathematical These visual models underscore the significance of the decomposition of cell dynamics additionally facilitates the computational decomposition of cellular dynamics computational modeling of cellular mechanisms that drive underlying morphogenesis. morphogenesis (Satulovsky et al., 2008). Methods In this paper, we use the Processing programming language to visualize dynamic cell behaviors driving morphogenesis in the Introduction developing nervous system. Based on in vivo time-lapse image sequences, we created models of cell dynamics underlying two Processing is a Java based software language and environment morphogenetic processes in the developing nervous system. -
A Sibling's Guide to Psychosis
Information, Ideas and Resources AA SSiibblliinngg’’ss GGuuiiddee ttoo PPssyycchhoossiiss Information, Ideas and Resources Prepared by: Sharon Mulder A Sibling’s GuideElizabeth Lines to Psychosis: • to the brothers and sisters who came forward to share their stories and offer suggestions that might help other families facingAcknowledgements similar challenges • to the early psychosis clinics and staff at the Psychotic Disorders Clinic Thank(Hamilton, you… Ontario), Early Psychosis Prevention and Intervention Service (Winnipeg, Manitoba) and the Early Psychosis Program (St. John’s, Newfoundland) who assisted us in the collection of sibling experiences through focus groups and individual interviews • to parent members of the national first episode family network for providing valuable perspectives on the family experience of psychosis • to the South Worcestershire Early Intervention Service, United Kingdom’s booklet “Information about psychosis for brothers and sisters” • to the Public Health Agency of Canada, through the Population Health Fund, for ongoing support that has allowed us to appreciate and respond to the complexities that define “early psychosis intervention.” Sharon Mulder Elizabeth Lines This document was produced by the Canadian Mental Health Association, National Office as part of its early psychosis intervention project, funded by the Population Health Fund of the Public Health Agency of Canada (PHAC). The contents herein do not necessarily represent the views of PHAC. Visit CMHA’s web site (www.cmha.ca) to find this guide and other materials produced by CMHA’s early psychosis intervention initiatives. Additional copies of this guide may be available for a limited time. Direct inquiries to www.cmha.ca If you have any comments or questions, contact: [email protected] Canadian Mental Health Association National Office 8 King Street East, Suite 810 Toronto, ON M5C 1B5 Tel: 416-484-7750 Fax: 416-484-4617 Aussi disponible en français. -
Theory and Practice of Lineage Tracing
REGENERATIVE MEDICINE Theory and Practice of Lineage Tracing a,b YA-CHIEH HSU Key Words. Cell surface markers • Stem cell-microenvironment interactions • Cell cycle • Cell biology • Adult stem cells aDepartment of Stem Cell ABSTRACT and Regenerative Biology, Lineage tracing is a method that delineates all progeny produced by a single cell or a group of Harvard University, cells. The possibility of performing lineage tracing initiated the field of Developmental Biology Cambridge, Massachusetts, and continues to revolutionize Stem Cell Biology. Here, I introduce the principles behind a suc- USA; bHarvard Stem Cell cessful lineage-tracing experiment. In addition, I summarize and compare different methods for Institute, Cambridge, conducting lineage tracing and provide examples of how these strategies can be implemented Massachusetts, USA to answer fundamental questions in development and regeneration. The advantages and limita- Correspondence: Ya-Chieh Hsu, tions of each method are also discussed. STEM CELLS 2015;33:3197–3204 Department of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., SIGNIFICANCE STATEMENT Cambridge, Massachusetts 02138, USA. Telephone: Lineage relationships allow one to understand the cellular hierarchy of a tissue or organ, which (617) 496-3757; Fax: (617) 496- is central to both Developmental Biology and Stem Cell Biology. Different approaches have 3763; e-mail: yachiehhsu@fas. been developed to conduct lineage tracing. Understanding the underlying basis of these harvard.edu approaches, as well as their advantages and limitations, will allow one to choose the most Received March 26, 2015; appropriate method for a given question. accepted for publication June 23, 2015; first published online STEM CELLS in EXPRESS August 3, cells that are marked at the initial time point, 2015. -
Emergence of Embryo Shape During Cleavage Divisions Alex Mcdougall, Janet Chenevert, Benoît Godard, Rémi Dumollard
Emergence of embryo shape during cleavage divisions Alex Mcdougall, Janet Chenevert, Benoît Godard, Rémi Dumollard To cite this version: Alex Mcdougall, Janet Chenevert, Benoît Godard, Rémi Dumollard. Emergence of embryo shape during cleavage divisions. Evo-Devo: Non-model Species in Cell and Developmental Biology, 2019. hal-02362892 HAL Id: hal-02362892 https://hal.archives-ouvertes.fr/hal-02362892 Submitted on 14 Nov 2019 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Emergence of embryo shape during cleavage divisions Alex McDougall1, Janet Chenevert1, Benoit G. Godard2 and Remi Dumollard1 1. Sorbonne Université, CNRS, Laboratoire de Biologie du Développement de Villefranche‐sur‐mer (LBDV), UMR7009, 181 chemin du Lazaret, 06230 Villefranche‐sur‐Mer, France 2. Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria Abstract Cells are arranged into species‐specific patterns during early embryogenesis. Such cell division patterns are important since they often reflect the distribution of localized cortical factors from eggs/fertilized eggs to specific cells as well as the emergence of organismal form. However, it has proven difficult to reveal the mechanisms that underlie the emergence of cell positioning patterns that underlie embryonic shape, likely because a system‐level approach is required that integrates cell biological, genetic, developmental and mechanical parameters. -
Transformations of Lamarckism Vienna Series in Theoretical Biology Gerd B
Transformations of Lamarckism Vienna Series in Theoretical Biology Gerd B. M ü ller, G ü nter P. Wagner, and Werner Callebaut, editors The Evolution of Cognition , edited by Cecilia Heyes and Ludwig Huber, 2000 Origination of Organismal Form: Beyond the Gene in Development and Evolutionary Biology , edited by Gerd B. M ü ller and Stuart A. Newman, 2003 Environment, Development, and Evolution: Toward a Synthesis , edited by Brian K. Hall, Roy D. Pearson, and Gerd B. M ü ller, 2004 Evolution of Communication Systems: A Comparative Approach , edited by D. Kimbrough Oller and Ulrike Griebel, 2004 Modularity: Understanding the Development and Evolution of Natural Complex Systems , edited by Werner Callebaut and Diego Rasskin-Gutman, 2005 Compositional Evolution: The Impact of Sex, Symbiosis, and Modularity on the Gradualist Framework of Evolution , by Richard A. Watson, 2006 Biological Emergences: Evolution by Natural Experiment , by Robert G. B. Reid, 2007 Modeling Biology: Structure, Behaviors, Evolution , edited by Manfred D. Laubichler and Gerd B. M ü ller, 2007 Evolution of Communicative Flexibility: Complexity, Creativity, and Adaptability in Human and Animal Communication , edited by Kimbrough D. Oller and Ulrike Griebel, 2008 Functions in Biological and Artifi cial Worlds: Comparative Philosophical Perspectives , edited by Ulrich Krohs and Peter Kroes, 2009 Cognitive Biology: Evolutionary and Developmental Perspectives on Mind, Brain, and Behavior , edited by Luca Tommasi, Mary A. Peterson, and Lynn Nadel, 2009 Innovation in Cultural Systems: Contributions from Evolutionary Anthropology , edited by Michael J. O ’ Brien and Stephen J. Shennan, 2010 The Major Transitions in Evolution Revisited , edited by Brett Calcott and Kim Sterelny, 2011 Transformations of Lamarckism: From Subtle Fluids to Molecular Biology , edited by Snait B. -
It's T-ALL About Notch
Oncogene (2008) 27, 5082–5091 & 2008 Macmillan Publishers Limited All rights reserved 0950-9232/08 $30.00 www.nature.com/onc REVIEW It’s T-ALL about Notch RM Demarest1, F Ratti1 and AJ Capobianco Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA, USA T-cell acute lymphoblastic leukemia (T-ALL) is an about T-ALL make it a more aggressive disease with a aggressive subset ofALL with poor clinical outcome poorer clinical outcome than B-ALL. T-ALL patients compared to B-ALL. Therefore, to improve treatment, it have a higher percentage of induction failure, and rate is imperative to delineate the molecular blueprint ofthis of relapse and invasion into the central nervous system disease. This review describes the central role that the (reviewed in Aifantis et al., 2008). The challenge to Notch pathway plays in T-ALL development. We also acquiring 100% remission in T-ALL treatment is the discuss the interactions between Notch and the tumor subset of patients (20–25%) whose disease is refractory suppressors Ikaros and p53. Loss ofIkaros, a direct to initial treatments or relapses after a short remission repressor ofNotch target genes, and suppression ofp53- period due to drug resistance. Therefore, it is imperative mediated apoptosis are essential for development of this to delineate the molecular blueprint that collectively neoplasm. In addition to the activating mutations of accounts for the variety of subtypes in T-ALL. This will Notch previously described, this review will outline allow for the development of targeted therapies that combinations ofmutations in pathways that contribute inhibit T-ALL growth by disrupting the critical path- to Notch signaling and appear to drive T-ALL develop- ways responsible for the neoplasm. -
Post-Marital Residence Patterns Show Lineage-Specific Evolution
Evolution and Human Behavior xxx (xxxx) xxx–xxx Contents lists available at ScienceDirect Evolution and Human Behavior journal homepage: www.elsevier.com/locate/ens Post-marital residence patterns show lineage-specific evolution Jiří C. Moraveca, Quentin Atkinsonb, Claire Bowernc, Simon J. Greenhilld,e, Fiona M. Jordanf, Robert M. Rossf,g,h, Russell Grayb,e, Stephen Marslandi,*, Murray P. Coxa,* a Statistics and Bioinformatics Group, Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand b Department of Psychology, University of Auckland, Auckland, New Zealand c Department of Linguistics, Yale University, New Haven, CT 06511, USA d ARC Centre of Excellence for the Dynamics of Language, Australian National University, Canberra, ACT 0200, Australia e Max Planck Institute for the Science of Human History, Jena D-07745, Germany f Department of Anthropology and Archaeology, University of Bristol, Bristol BS8 1TH, UK g Institute for Cognitive and Evolutionary Anthropology, School of Anthropology and Museum Ethnography, University of Oxford, Oxford OX1 2JD, UK h ARC Centre of Excellence in Cognition and its Disorders, Department of Psychology, Royal Holloway, University of London, Surrey TW20 0EX, UK i School of Mathematics and Statistics, Victoria University of Wellington, Wellington, New Zealand ARTICLE INFO ABSTRACT Keywords: Where a newly-married couple lives, termed post-marital residence, varies cross-culturally and changes over Kinship time. While many factors have been proposed as drivers of this change, among them general features of human Post-marital residence societies like warfare, migration and gendered division of subsistence labour, little is known about whether Cross-cultural comparison changes in residence patterns exhibit global regularities. -
Nicotinic Receptor Alpha7 Expression During Tooth Morphogenesis Reveals Functional Pleiotropy
Nicotinic Receptor Alpha7 Expression during Tooth Morphogenesis Reveals Functional Pleiotropy Scott W. Rogers1,2*, Lorise C. Gahring1,3 1 Geriatric Research, Education and Clinical Center, Veteran’s Administration, Salt Lake City, Utah, United States of America, 2 Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, Utah, United States of America, 3 Division of Geriatrics, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, United States of America Abstract The expression of nicotinic acetylcholine receptor (nAChR) subtype, alpha7, was investigated in the developing teeth of mice that were modified through homologous recombination to express a bi-cistronic IRES-driven tau-enhanced green fluorescent protein (GFP); alpha7GFP) or IRES-Cre (alpha7Cre). The expression of alpha7GFP was detected first in cells of the condensing mesenchyme at embryonic (E) day E13.5 where it intensifies through E14.5. This expression ends abruptly at E15.5, but was again observed in ameloblasts of incisors at E16.5 or molar ameloblasts by E17.5–E18.5. This expression remains detectable until molar enamel deposition is completed or throughout life as in the constantly erupting mouse incisors. The expression of alpha7GFP also identifies all stages of innervation of the tooth organ. Ablation of the alpha7-cell lineage using a conditional alpha7Cre6ROSA26-LoxP(diphtheria toxin A) strategy substantially reduced the mesenchyme and this corresponded with excessive epithelium overgrowth consistent with an instructive role by these cells during ectoderm patterning. However, alpha7knock-out (KO) mice exhibited normal tooth size and shape indicating that under normal conditions alpha7 expression is dispensable to this process. -
Cleavage Pattern and Development of Isolated D Blastomeres in Bivalves
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Tsukuba Repository Cleavage pattern and development of isolated D blastomeres in bivalves 著者 Hashimoto Naoki, Kurita Yoshihisa, Murakami Kana, Wada Hiroshi journal or Journal of Experimental Zoology Part B: publication title Molecular and Developmental Evolution volume 234 number 1 page range 13-21 year 2015-01 権利 (C) 2014 WILEY PERIODICALS, INC. This is the peer reviewed version of the following article: Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 324,1,2015, which has been published in final form at DOI: 10.1002/jez.b.22585.This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving. URL http://hdl.handle.net/2241/00123041 doi: 10.1002/jez.b.22585 1. Complete title of paper Cleavage pattern and development of isolated D blastomeres in bivalves 2. Author’s names Naoki Hashimoto1*, Yoshihisa Kurita1, 2, Kana Murakami1, Hiroshi Wada1 3. Institutional affiliations 1 Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, Japan 2 Fishery Research Laboratory, Kyushu University, Fukutsu 811-3304, Japan 4. Total number of text and figures One manuscript file, two tables, six figure files and two movie files. 5. Abbreviated title Cleavage and development of isolated blastomeres 6. Correspondence to: Name: Naoki Hashimoto. Address: Graduate School of Life and Environmental Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba 305-8572, Japan E-mail: [email protected] Tel & Fax: +08-29-4671 7. Supporting grant information Grant-in-Aid for JSPS Fellows. -
Molecular Cell and Developmental Biology Graduate Program 2018-2019
Molecular Cell and Developmental Biology Graduate Program 2018-2019 The Ph.D. track in Molecular Cell and Developmental Biology (MCD) is designed to prepare students for productive careers in biological research and teaching. This training program emphasizes applying diverse approaches, including biochemistry, genetics, genomics, and imaging, to addressing critical questions in molecular, cellular, and developmental biology. Interdisciplinary research is encouraged and supported by a diverse group of faculty from the Departments of Molecular Cell & Developmental Biology (MCD), Chemistry & Biochemistry (Chem), Microbiology & Environmental Toxicology (METX), Biomolecular Engineering (BME), the Santa Cruz Institute for Particle Physics (Physics), and Ecology & Evolutionary Biology (EEB). MCD Faculty James Ackman Visualizing structured activity throughout the developing vertebrate brain Manny Ares Mechanisms and regulation of splicing machinery; structure and function of small RNAs Joshua Arribere Analyzing RNA quality control in C. elegans Needhi Bhalla Meiotic chromosome dynamics Hinrich Boeger Chromatin structure and gene regulation Barry Bowman Membrane biochemistry, genetics, and molecular biology Susan Carpenter Long non-coding RNAs in innate immunity Bin Chen Molecular control of neuronal identity and connectivity in mammalian brains David Feldheim Topographic mapping in vertebrates/CNS Grant Hartzog Chromatin and transcription Lindsay Hinck Molecular basis of neuronal chemotropism Melissa Jurica Structural approaches to large macromolecular -
Downloaded Manually1
The Journal Coverage of Web of Science and Scopus: a Comparative Analysis Philippe Mongeon and Adèle Paul-Hus [email protected]; [email protected] Université de Montréal, École de bibliothéconomie et des sciences de l'information, C.P. 6128, Succ. Centre-Ville, H3C 3J7 Montréal, Qc, Canada Abstract Bibliometric methods are used in multiple fields for a variety of purposes, namely for research evaluation. Most bibliometric analyses have in common their data sources: Thomson Reuters’ Web of Science (WoS) and Elsevier’s Scopus. This research compares the journal coverage of both databases in terms of fields, countries and languages, using Ulrich’s extensive periodical directory as a base for comparison. Results indicate that the use of either WoS or Scopus for research evaluation may introduce biases that favor Natural Sciences and Engineering as well as Biomedical Research to the detriment of Social Sciences and Arts and Humanities. Similarly, English-language journals are overrepresented to the detriment of other languages. While both databases share these biases, their coverage differs substantially. As a consequence, the results of bibliometric analyses may vary depending on the database used. Keywords Bibliometrics, citations indexes, Scopus, Web of Science, research evaluation Introduction Bibliometric and scientometric methods have multiple and varied application realms, that goes from information science, sociology and history of science to research evaluation and scientific policy (Gingras, 2014). Large scale bibliometric research was made possible by the creation and development of the Science Citation Index (SCI) in 1963, which is now part of Web of Science (WoS) alongside two other indexes: the Social Science Citation Index (SSCI) and the Arts and Humanities Citation Index (A&HCI) (Wouters, 2006).