Weisz Ora a Curriculum Vitae.Pdf

2007- University of Pittsburgh School of Medicine Professor of Medicine and Cell Biology

2003-2007 University of Pittsburgh Health Sciences Assistant Director Office of Academic Career Development

2001- University of Pittsburgh School of Medicine Affiliate Faculty McGowan Institute for Regenerative Medicine

2001-2007 University of Pittsburgh School of Medicine Associate Professor of Medicine and Cell Biology and Physiology (tenured)

1995-2001 University of Pittsburgh School of Medicine Assistant Professor of Medicine (Renal- Electrolyte Division) and Cell Biology and Physiology

MEMBERSHIPS IN PROFESSIONAL and SCIENTIFIC SOCIETIES

Yale Science and Engineering Association 1984-88 Sigma Xi 1984- American Society for Cell Biology 1990- American Assn. for the Advancement of Science 1995- Association for Women in Science 1997-2005 American Society of Nephrology 2000- The American Physiological Society 2004- National Kidney Foundation 2007-2011

HONORS

Presidential Scholar finalist (top 1000 U.S. high school students) 1980 B.S., Cum Laude, Yale University 1984 Sigma Xi 1984 NIH NRSA, Postdoctoral fellowship 1990-1993 Univ. of Pittsburgh Senior Vice-Chancellor’s Research Seminar Series 2000 American Journal of Physiology Star Reviewer 2007 Academy of Master Educators, University of Pittsburgh School of Medicine 2009- Fellow, Executive Leadership in Academic Medicine (ELAM) Program 2010-2011 Distinguished Mentor Award Finalist, School of Medicine 2011 Member, ICRE Mentoring Network 2012- Elected to Johns Hopkins Society of Scholars 2014 Distinguished Mentor Award, School of Medicine 2014 University of Pittsburgh Postdoctoral Association Advocate Award 2015 Elected to Council, American Society of Cell Biology 2015-2018 Fellow, American Physiological Society 2019 Fellow, American Society of Cell Biology 2020

PUBLICATIONS

Original peer reviewed articles

1. Wood TG, Weisz OA, and Kozarich JW (1984) Acyl-enzyme exchange detection by intermolecular oxygen scrambling: an application of the 18O-isotope effect in 13C NMR. J Amer Chem Soc. 106:2222- 2223. Curr cu um V tae Ora A. We sz

2. Brandley BK, Weisz OA, and Schnaar RL (1987) Cell attachment and long-term growth on derivatizable polyacrylamide surfaces. J Biol Chem. 262:6431-6437.

3. Weisz OA and Schnaar RL (1990) Hepatocyte-mediated Coenzyme A transfer to carbohydrate- derivatized surfaces. Biochem Biophys Res Commun.167:67-73.

4. Rice KG, Weisz OA, Barthel T, Lee RT, and Lee YC (1990) Defined geometry of binding between triantennary glycopeptide and the asialoglycoprotein receptor of rat hepatocytes. J Biol Chem. 265:18429-18434.

5. Weisz OA and Schnaar RL (1991) Hepatocyte adhesion to carbohydrate-derivatized surfaces I Surface topography of the rat hepatic lectin. J Cell Biol. 115:485-493. PMCID: 2289166.

6. Weisz OA, and Schnaar RL (1991) Hepatocyte adhesion to carbohydrate-derivatized surfaces II Regulation of cytoskeletal organization and cell morphology. J Cell Biol. 115:495-504. PMCID: 2289152.

7. Weisz OA, Machamer CE, and Hubbard AL (1992) Rat liver dipeptidylpeptidase IV contains competing apical and basolateral targeting information. J Biol Chem. 267:22282-22288.

8. Weisz OA, Swift AM, and Machamer CE (1993) Oligomerization of a membrane protein correlates with its retention in the Golgi complex. J Cell Biol. 122:1185-1197 (featured in the Headlines section of Trends in Cell Biology 1993;3). PMCID: 2119850.

9. Jiang XS, Hill WG, Pilewski JM, and Weisz OA (1997) Glycosylation differences between a cystic fibrosis and rescued cell line are not CFTR-dependent. Am J Physiol- Lung Cell and Mol Physiol. 273:L913-L920.

10. Henkel JR and Weisz OA (1998) Influenza virus M2 protein slows transport along the secretory pathway. J Biol Chem. 273:6518-6524.

11. Henkel JR, Apodaca G, Altschuler Y, Hardy S, and Weisz OA (1998) Selective perturbation of apical membrane traffic by expression of influenza M2, an acid-activated ion channel, in polarized Madin-Darby canine kidney cells. Mol Biol Cell. 9:2477-2490. PMCID: 25516.

12. Rokaw MD, Wang J, Edinger RS, Weisz OA, Hui D, Middleton P, Shlyonsky V, Berdiev B K, Ismailov, I, Eaton DC, Benos DJ, and Johnson JP (1998) Carboxylmethylation of the beta subunit of xENaC regulates channel activity. J Biol Chem. 273:28746-28751.

13. Henkel JR, Popovich JL, Gibson GA, Watkins SC, and Weisz OA (1999) Selective perturbation of early endosome and/or TGN pH but not lysosome pH by dose-dependent expression of influenza M2 protein. J Biol Chem. 274:9854-9860.

14. Sevier CS, Weisz OA, Davis M, and Machamer CE (2000) Efficient export of the vesicular stomatitis virus glycoprotein from the endoplasmic reticulum requires a signal in the cytoplasmic tail that includes both tyrosine-based and di-acidic motifs. Mol Biol Cell. 11:13-22. PMCID: 14753.

15. Altschuler Y, Kinlough CL, Poland PA, Bruns JB, Apodaca G, Weisz OA, and Hughey RP (2000) Clathrin mediated endocytosis of MUC1 is modulated by its glycosylation state. Mol Biol Cell. 11:819-831. PMCID: 14813.

16. Henkel JR, Gibson GA, Poland PA, Ellis MA, Hughey RP, and Weisz OA (2000) Influenza M2 proton channel activity selectively inhibits TGN release of apical membrane and secreted proteins in polarized MDCK cells. J Cell Biol. 148:495-504 (highlighted in the In Brief section of Journal of Cell Biology 2000;148:1-2). PMCID: 2174804.

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17. Howard M, Jiang X, Beer Stolz D, Hill WG, Johnson JA, Watkins SC, Frizzell RA, Bruton CM, Robbins PD, and Weisz OA (2000) Forskolin-induced apical membrane insertion of virally-expressed, epitope- tagged CFTR in polarized MDCK cells. Am J Physiol- Cell Physiol. 279:C375-C382.

18. Weisz OA, Gibson GA, Roder J, and Jeromin A (2000) Overexpression of frequenin, a modulator of phosphatidylinositol 4-kinase, inhibits biosynthetic delivery to the apical surface of polarized Madin-Darby canine kidney cells. J Biol Chem. 275:24341-24347.

19. Gibson GA, Hill WG, and Weisz OA (2000) Evidence against the acidification hypothesis in cystic fibrosis. Am J Physiol- Cell Physiol. 279:C1088-1099.

20. Weisz OA, Wang J-M, Edinger RS, and Johnson JP (2000) Non-coordinate regulation of endogenous ENaC subunit expression at the apical membrane of A6 cells in response to various transporting conditions. J Biol Chem. 275:39886-39893.

21. Ihrke G, Bruns JR, Luzio JP, and Weisz OA. (2001) A novel lysosomal delivery route via the apical surface identified by the trafficking of endolyn in MDCK cells. EMBO J. 20:6256-6264. PMCID: 125743.

22. Bruns JR, Ellis MA, Jeromin A, and Weisz OA (2002) Multiple roles for phosphatidylinositol 4-kinase in biosynthetic transport in polarized MDCK cells. J Biol Chem. 277:2012-2018.

23. Lee E, Marcucci M, Daniell L, Pypaert M, Weisz OA, Ochoa, G-C, Farsad, K, Wenk, MR, and De Camilli, P (2002) Amphiphysin 2 (Bin1) and T-tubule biogenesis in muscle. Science. 297:1193-1196 (highlighted by the Faculty of 1000).

24. Puthenveedu M, Bruns JR, Weisz OA, and Linstedt, AD (2003) Basolateral cycling mediated by a lumenal domain targeting determinant. Mol Biol Cell. 14:1801-1807. PMCID: 165078.

25. Chen C, Weisz OA, Stolz DB, Watkins SC, and Montelaro RC (2004) Differential effects of actin cytoskeleton dynamics on equine infectious anemia virus particle production. J Virol. 78:882-891. PMCID: 368807.

26. Potter BA, Ihrke G, Bruns JR, Weixel KM, and Weisz OA (2004) Specific N-glycans direct apical delivery of transmembrane, but not soluble or GPI-anchored forms of endolyn in MDCK cells. Mol Biol Cell. 15:1407-1416 (highlighted by the Faculty of 1000). PMCID: 363156.

27. Mohan S, Bruns JR, Weixel KM, Edinger RS, Bruns JB, Kleyman TR, Johnson JP, and Weisz OA (2004) Differential current decay profiles of ENaC subunit combinations in polarized renal epithelial cells. J Biol Chem. 279:32071-32078.

28. Ellis MA, Miedel MT, Guerriero CJ, and Weisz OA (2004) ARF1-independent protein sorting and export from the trans-Golgi network. J Biol Chem. 279:52735-52743.

29. Weixel KM, Blumental-Perry A, Watkins SC, Aridor M, and Weisz OA (2005) Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinases J Biol Chem. 280:10501-10508.

30. Jin S, Zhang B, Weisz OA, and Montelaro RC (2005) Receptor-mediated entry by equine infectious anemia virus utilizes a pH-dependent endocytic pathway. J Virol. 79:14489-14497. PMCID: 1287590.

31. Chen C, Vincent O, Jin J, Weisz OA, and Montelaro RC (2005) Functions of early (AP-2) and late (AIP1/ALIX) endocytic proteins in equine infectious anemia virus budding. J Biol Chem. 280:40474- 40480.

32. Potter BA, Weixel KM, Bruns JR, Ihrke G, and Weisz OA (2006) N-glycans mediate apical recycling of the sialomucin endolyn in polarized MDCK cells. Traffic. 7:146-154 (highlighted by the Faculty of 1000).

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33. Kinlough CL, McMahan RJ, Poland PA, Bruns JB, Harkleroad KL, Stremple RJ, Kashlan OB, Weixel KM, Weisz OA, and Hughey RP (2006). MUC1 recycling is dependent on its palmitoylation. J Biol Chem. 281:12112-12122.

34. Miedel MT, Weixel KM, Bruns JR, Traub LM, and Weisz OA (2006) Posttranslational cleavage and adaptor protein complex-dependent trafficking of mucolipin-1. J Biol Chem. 281:12751-12759.

35. Guerriero CJ, Weixel KM, Bruns JR, and Weisz OA (2006) Phosphatidylinositol 5-kinase stimulates apical biosynthetic delivery via an Arp2/3-dependent mechanism. J Biol Chem. 281:15376-15384.

36. Ellis MA, and Weisz OA (2006) In vitro assays differentially recapitulate protein export from the trans- Golgi network. Anal Biochem. 354:314-315.

37. Blumental-Perry A, Haney CJ, Weixel KM, Watkins SC, Weisz OA, and Aridor M (2006) Phosphatidylinositol 4-phosphate formation at ER exit sites regulates ER export. Dev Cell. 11:671-682 (highlighted by the Faculty of 1000).

38. Lu C, Walker WH, Sun J, Weisz OA, Gibbs RB, Witchel SF, Sperling MA, and Menon RK (2006) Insulin-like peptide 6 (Insl6): Characterization of secretory status and post-translational modifications. Endocrinology. 147:5611-5623.

39. Guerriero CJ and Weisz OA (2007) The N-WASP inhibitor wiskostatin non-selectively perturbs membrane transport by decreasing cellular ATP levels Am J Physiol- Cell Physiol. 292:C1562-1566.

40. Bruns JB, Carattino MD, Sheng S, Maarouf AB, Weisz OA, Pilewski JM, Hughey RP, and Kleyman TR (2007) Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma subunit. J Biol Chem. 282:6153-6160.

41. Chen C, Jing J, Rubin M, Huang L, Sturgeon T, Weixel KM, Stolz DB, Watkins SC, Bamburg JR, Weisz OA, and Montelaro RC (2007) Association of Gag multimers with filamentous actin during equine infectious anemia virus assembly. Curr HIV Res. 5:315-323.

42. Jin J, Sturgeon T, Chen C, Watkins SC, Weisz OA, and Montelaro RC (2007) Distinct intracellular trafficking of EIAV and HIV-1 Gag during viral assembly and budding revealed by bimolecular fluorescence complementation assays. J Virol. 81:11226-11235. PMCID: 2045577.

43. Cresawn KO, Potter BA, Oztan A, Guerriero CJ, Ihrke G, Goldenring JR, Apodaca G, and Weisz OA (2007) Differential involvement of endocytic compartments in the biosynthetic traffic of apical proteins. EMBO J. 26:3737-3748 (highlighted by the Faculty of 1000). PMCID: 1952228.

44. Oztan A, Silvis M, Weisz OA, Bradbury NA, Hsu S-C, Goldenring JR, Yeaman C, and Apodaca G. (2007) Exocyst requirement for endocytic traffic directed toward the apical and basolateral poles of polarized MDCK cells. Mol Biol Cell. 18:3978-3992. PMCID: 1995710.

45. Weixel KM, Edinger RS, Kester L, Guerriero CJ, Wang H, Fang L, Kleyman TR, Welling PA, Weisz OA, and Johnson JP (2007) Phosphatidylinositol 4-phosphate 5-kinase reduces cell surface expression of the epithelial sodium channel (ENaC) in cultured collecting duct cells. J Biol Chem. 282:36534-36542.

46. Miedel MT, Rbaibi Y, Guerriero CJ, Colletti G, Weixel KM, Weisz OA* and Kiselyov K* (2008) Membrane traffic and turnover in TRP-ML1 deficient cells: A revised model for Mucolipidosis Type IV pathogenesis, J Exp Med. 205:1477-1490 *corresponding authors (Cover article; highlighted in the In This Issue section of Journal of Experimental Medicine 2008; 205:1247). PMCID: 2413042.

47. Guerriero CJ, Lai Y, and Weisz OA (2008) Differential sorting and Golgi export requirements for raft- associated and raft-independent apical proteins along the biosynthetic pathway. J Biol Chem. 283:18040- 18047. PMCID: 2440606.

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48. Leaphart CL, Dai S, Gribar SC, Richardson W, Ozolek J, Shi X, Bruns JR, Branca M, Li J, Weisz OA, Sodhi C, and Hackam DJ (2008) Interferon-gamma inhibits enterocyte migration by reversibly displacing connexin43 from lipid rafts. Am J Physiol-Gastroint and Liver Physiol. 295:G259-G269. PMCID: 2536784.

49. Khandelwal P, Ruiz WG, Balestreire-Hawryluk E, Weisz OA, Goldenring JR, and Apodaca G (2008) Rab11a-dependent exocytosis of discoidal/fusiform vesicles in bladder umbrella cells. Proc Natl Acad Sci USA. 105:15773-15778. PMCID: 2572972.

50. Mattila PE, Kinlough CL, Bruns JR, Weisz OA, and Hughey RP (2009) MUC1 traverses apical recycling endosomes along the biosynthetic pathway in polarized MDCK cells. Biol Chem. 2009; 390; 551-556. PMCID: 3625034.

51. Jin J, Sturgeon T, Weisz OA, Mothes W, and Montelaro RC (2009) HIV-1 matrix dependent membrane targeting is regulated by Gag mRNA trafficking. PLoS One. 4; e6551. PMCID: 2717210.

52. Cui S, Guerriero CJ, Szalinski CM, Kinlough CL, Hughey RP, and Weisz OA (2010) OCRL1 function in renal epithelial membrane traffic. Am J Physiol- Renal Physiol. 298: F335-F345. PMCID: 2822509.

53 Mo D, Potter BA, Bertrand CA, Hildebrand JD, Bruns JR, and Weisz OA (2010) Nucleofection disrupts tight junction fence function to alter membrane polarity of renal epithelial cells. Am J Physiol- Renal Physiol. 299:F1178-F1184. PMCID: 2980404.

54. Rondanino C Poland PA, Kinlough CL, Li H, Rbaibi Y, Myerburg MM, Al-bataineh M, Kashlan OB, Pastor-Soler N, Hallows KR, Weisz OA, Apodaca G, and Hughey RP (2011) Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. Am J Physiol- Renal Physiol. 301:F622-633. PMCID: 3174547.

55. Kinlough CL, Poland PA, Gendler SJ, Mattila PE, Mo D, Weisz OA, and Hughey RP (2011) Core- glycosylated mucin-like repeats from MUC1 are an apical targeting signal. J Biol Chem. 286:39072-39081 (highlighted by the Faculty of 1000). PMCID: 3234732.

56. Mattila PE, Youker RT, Mo D, Bruns JR, Cresawn KO, Hughey RP, Ihrke G, and Weisz OA (2012) Multiple biosynthetic trafficking routes for apically secreted proteins in MDCK cells. Traffic. 13:433-442. PMCID: 3276681.

57. Colletti GA, Miedel MT, Quinn J, Andharia N, Weisz OA, and Kiselyov K (2012). Loss of the lysosomal ion channel TRPML1 leads to cathepsin B-dependent apoptosis. J Biol Chem. 287:8082-8091. PMCID: 3318733.

58. Rbaibi Y, Cui S, Mo D, Carattino M, Rohatgi, R, Satlin LM, Szalinski CM, Swanhart LM, Fölsch H, Hukriede NA, and Weisz OA (2012) OCRL1 modulates cilia length in renal epithelial cells. Traffic. 13:1295-1305. PMCID: 3652247.

59. Mo D, Costa SA, Ihrke G, Youker RT, Pastor-Soler N, Hughey RP, and Weisz OA (2012) Sialylation of N-linked glycans mediates apical delivery of endolyn in MDCK cells via a galectin-9 dependent mechanism. Mol Biol Cell. 23:3636-3646 (highlighted in Mol Biol Cell). PMCID: 3442411.

60. Mo D, Ihrke G, Costa SA, Brilli L, Labilloy A, Halfter W, Cianciolo Cosentino C, Hukriede NA, and Weisz OA (2013) Apical targeting and endocytosis of the sialomucin endolyn are essential for establishment of zebrafish pronephric kidney function. J Cell Sci. 125: 5546-5554 (highlighted by the Faculty of 1000). PMCID: 3561862.

61. Szalinski CM, Guerriero CJ, Ruiz WG, Docter BE, Rbaibi Y, Pastor-Soler N, Apodaca G, Puthenveedu MA, and Weisz OA (2013) PIP5KIb selectively modulates apical endocytosis in polarized renal epithelial cells. PLoS One. 8:e53790. PMCID: 3547069.

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62. Youker RT, Bruns JR, Costa SA, Rbaibi Y, Lanni F, Kashlan OB, Teng H, and Weisz OA (2013) Multiple motifs regulate apical sorting of p75 via a mechanism that involves dimerization and higher-order oligomerization. Mol Biol Cell. 24:1996-2007. PMCID: 3681702.

63. Razawi H, Kinlough CL, Staubach S, Poland PA, Rbaibi Y, Weisz OA, Hughey RP, and Hanisch, FG (2013) Evidence for core 2 to core 1 O-glycan remodeling during recycling of MUC1. Glycobiology. 23:935-945. PMCID: 3695752.

64. Labilloy A, Youker RT, Bruns JR, Kukic I, Kiselyov K, Halfter W, Finegold D, do Monte SJ, and Weisz OA (2014) Altered dynamics of a lipid raft associated protein in a kidney model of Fabry disease. Mol Genet Metab. 111:184-192. PMCID: 3946758.

65. Mattila PE, Raghavan V, Rbaibi Y, Baty CJ, and Weisz OA (2014) Rab11a-positive compartments in proximal tubule cells sort fluid phase and membrane cargo. Am J Physiol- Cell Physiol. 306:C441-449. (featured as an Editorial Focus 306:C428-430). PMCID: 4042618.

66. Szalinski CM, Labilloy A, Bruns JR, and Weisz OA (2014) VAMP7 modulates ciliary biogenesis in renal epithelial cells. PLoS One. 9:e86425. PMCID: 3899255.

67. Raghavan V, Rbaibi R, Pastor-Soler N, Carattino MD, and Weisz OA (2014) Shear stress dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia. Proc Natl Acad Sci USA.111:8506-8511. PMCID: 4060694.

68. Sneddon WB, Ruiz GW, Gallo LI, Xiao K, Zhang Q, Rbaibi Y, Weisz OA, Apodaca GL, and Friedman PA (2016) Convergent signaling pathways regulate parathyroid hormone and fibroblast growth factor-23 action on NPT2A-mediated phosphate transport. J Biol Chem, 291:18632-18642. PMID: 27432882; PMCID: PMC5009241

69. Pereira EM, Labilloy A, Eshbach ML, Roy A, Subramanya AR, Monte S, Labilloy G, and Weisz OA (2016) Characterization and phosphoproteomic analysis of a human immortalized podocyte model of Fabry disease generated using CRISPR/Cas9 technology. Am J Physiol- Renal Physiol. 311:F1015- F1024. PMID: 27681560; PMCID: PMC5130460.

70. Eshbach ML, Kaur A, Rbaibi Y, Tejero J, and Weisz OA (2017) Hemoglobin inhibits albumin uptake by proximal tubule cells: implications for sickle cell disease. Am J Physiol- Cell Physiol. 312:C733-C740. (featured as “Image of the Week” for AJP-Cell Physiology Social Media; highlighted in APSselect) PMID: 28615248; PMCID: PMC5494590.

71. Eshbach ML, Sethi R, Avula R, Lamb J, Hollingshead DJ, Finegold DN, Locker J, Chandran UR, and Weisz OA (2017) The transcriptome of the Didelphis virginiana opossum kidney OK proximal tubule cell line. Am J Physiol- Renal Physiol. 313:F585-F595. PMID: 28356267; PMCID: PMC5494590.

72. Long KR, Shipman KE, Rbaibi Y, Menshikova E, Ritov VB, Eshbach ML, Jiang Y, Jackson EK, Baty CJ, and Weisz OA (2017) Proximal tubule apical endocytosis is modulated by fluid shear stress via an mTOR-dependent pathway. Mol Biol Cell. 28:2508-2517. (highlighted by the Faculty of 1000). PMID: 28720662; PMCID: PMC5597323.

73. Bhattacharyya S, Jean-Alphonse F, Raghavan V, Vilardaga J-P, Carattino MD, and Weisz OA (2017) Cdc42 couples fluid shear stress to apical endocytosis in proximal tubule cells. Physiol Rep. 2017 Oct;5(19):e13460. doi: 10.14814/phy2.13460. PMID: 29038362; PMCID: PMC5641940.

74. Tomich AD, Klontz EH, Deredge D, Barnard JP, McElheny CL, Eshbach ML, Weisz OA, Patrick Wintrode P, Doi Y, Sundberg EJ and Sluis-Cremer N (2019) Small molecule inhibitor of FosA expands fosfomycin activity to multidrug-resistant Gram-negative pathogens. Antimicrobial Agents and Chemotherapy. 63:e01524-18. doi: 10.1128/AAC.01524-18. PMID: 30642934

75. Ren Q, Gliozzi ML, Rittenhouse NL, Edmunds LR, Rbaibi Y, Locker JD, Poholek AC, Jurczak MJ, Baty CJ, and Weisz OA (2019) Shear stress and oxygen availability drive differential changes in OK Curr cu um V tae Ora A. We sz

7 proximal tubule cell metabolism and endocytosis. Traffic. 20:448-459. doi: 10.1111/tra.12648. PMCID: PMC7055529.

76. Gliozzi ML, Rbaibi Y, Long KR, Vitturi DA, and Weisz OA (2019) Hemoglobin alters vitamin carrier uptake and vitamin D metabolism in proximal tubule cells: implications for sickle cell disease. Am J Physiol- Cell Physiol. 317:C993-C1000. doi: 10.1152/ajpcell.00287.2019. PMID: 31509446; PMCID: PMC6879883.

77. Gliozzi ML, Espiritu E, Shipman KE, Rbaibi Y, Long KR, Roy N, Duncan AW, Lazzara MJ, Hukriede NA, Baty CJ, and Weisz OA (2020) Effects of proximal tubule shortening on protein excretion in a Lowe Syndrome model. J Am Soc Nephrol. 31:67-83. doi: https://doi.org/10.1681/ASN.2019020125.

78. Long KR, Rbaibi Y, Gliozzi ML, and Weisz OA (2020) Differential kidney proximal tubule cell responses to protein overload by albumin and its ligands. Am J Physiol- Renal Physiol. 318:F851–F859. doi:10.1152/ajprenal.00490.2019. PMID: 32068462

79. Ren Q, Weyer K, Rbaibi Y, Long KR, Tan RJ, Nielsen R, Christensen EI, Baty CJ, Kashlan OB, and Weisz OA (2020) Distinct functions of megalin and cubilin receptors in recovery of normal and nephrotic levels of filtered albumin. Am J Physiol- Renal Physiol. 318:F1284-1294. doi: 10.1152/ajprenal.00030.2020. PMID: 32200668

80. Park HJ, Fan Z, Bai Y, Ren Q, Rbaibi Y, Long KR, Gliozzi ML, Rittenhouse N, Locker JD, Poholek AC, and Weisz OA. Transcriptional programs driving shear stress-induced differentiation of kidney proximal tubule cells in culture. Frontiers in Physiol. 11:587358. doi: 10.3389/fphys.2020.587358.

Other peer reviewed publications

1. Weisz OA (2003) Organelle acidification and disease. Traffic. 4:57-64.

2. Weisz OA (2003) Acidification and protein traffic. Int Rev Cytol. 226:259-319.

3. Weisz OA and Johnson JP (2003) Non-coordinate regulation of ENaC: Paradigm lost? Am J Physiol. 285:F833-842.

4. Potter BA, Hughey RP, and Weisz OA (2006) The role of N- and O-glycans in polarized biosynthetic sorting. Am J Physiol. 290:C1-10.

5. Ellis MA, Potter BA, Cresawn KO, and Weisz OA (2006) Polarized biosynthetic traffic in renal epithelial cells: sorting, sorting, everywhere. Am J Physiol. 291:F707-713.

6. Butterworth MB, Weisz OA, and Johnson JP (2008) Some assembly required: putting the epithelial sodium channel together. J Biol Chem. 283:35305-35309.

7. Fölsch H, Mattila PE, and Weisz OA (2009) Taking the scenic route: Biosynthetic traffic to the plasma membrane in polarized epithelial cells. Traffic. 10; 972-981.

8. Weisz OA and Rodriguez-Boulan E (2009) Apical trafficking in epithelial cells: signals, clusters and motors. J Cell Sci. 122:4253-4266.

9. Welling, PA and Weisz OA (2010) Sorting it out in endosomes: An emerging concept in transport regulation. Physiology. 25:280-292.

10. Weisz OA (2013) High-tailing it to the apical surface: focus on “Apical targeting of the P2Y4 receptor is directed by hydrophobic and basic residues in the cytoplasmic tail”. Am J Physiol. 304:C226-227.

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11. Little M, Brown D, Humphreys B, McMahon A, Miner JH, Sands JM, Weisz OA, Mullins C, and Hoshizaki D (2014) The critical value of defining kidney biology to understanding renal disease. Clin J Amer Soc Nephrol. 9:809-811.

12. Raghavan V and Weisz OA (2015) Flow stimulated endocytosis in the proximal tubule. Curr Opin Nephrol Hypertens. 24:359-365. PMCID: PMC4494861

13. Raghavan V and Weisz OA (2015) Discerning the role of mechanosensors in regulating proximal tubule function. Am J Physiol.310:F1-F5. PMID: 26662200; PMCID: PMC4675802

14. Eshbach ML and Weisz OA (2017) Receptor mediated endocytosis in the proximal tubule. Annu Rev Physiol. 79:425-448. PMID: 27813828; PMCID: PMC5512543.

15. Baty CJ and Weisz OA (2018) Lemmings into the sea or back across the bridge? The fate of albumin in nephrotic syndrome. Kidney International. 93:296-298. PMID: 29389392

16. Labilloy A and Weisz OA (2019) Lose the Lipid: Renoprotection conferred by Gb3 synthase knockout. Kidney International. 96:270-272. PMID: 31331463

17. Weisz OA (2020) Targeting PIs to improve PTs: A new approach to treatment of genetic diseases of the proximal tubule. Kidney International. 98:824-826.

18. Shipman KE and Weisz OA (2020) Making a dent in Dent disease. Function. 2020;1(2):zqaa017. doi: 10.1093/function/zqaa017. PMID: 33015630; PMCID: PMC7519470.

Other publications

1. Weisz O and Schell M (1991) Chartjunk (letter to the editor) Amer. Scientist. 79:4.

2. Weisz OA (1994) Meeting the nation’s needs for biomedical and behavioral scientists. Summary of the 1993 Public Hearing National Research Council publication. p 93.

3. Rao G, Kanter SL, Weisz, OA, Thompson A, Ratti T, and Woodward JE (2013) Individualized strategic planning for faculty development in medical schools. Med Educ Dev. 3:e2:5-8.

4. Masur S, Näthke I, Roecklein-Canfield J, and Weisz O (2013) We’ve made it easier for ASCB members who are parents to attend the annual meeting. ASCB newsletter Women in Cell Biology column, 36 (7) pp.10-11.

5. Munson M, Weisz O, and Masur S (2014) Juggling on the ladder: institutional awards help faculty overcome early-mid career obstacles. ASCB newsletter Women in Cell Biology column, 37 (5) pp.9-11.

Book chapters

1. Weisz OA and Machamer CE (1994) Use of recombinant vaccinia virus vectors for cell biology. Meth Cell Biol. 43:137-159.

2. Weisz OA (2014) Protein Targeting. In: eLS 2014, John Wiley & Sons Ltd: Chichester http://www.els.net/ [DOI: 10.1002/9780470015902.a0005291.pub2].

3. Weisz OA and Fölsch H (2015) Molecular mechanisms of apical and basolateral sorting in polarized epithelial cells. Ion Channels and Transporters of Epithelia in Health and Disease, KL Hamilton and DC Devor, eds (Springer) Chapter 7, pp 279-302.

PROFESSIONAL ACTIVITES

TEACHING Curr cu um V tae Ora A. We sz

Courses and tutorials

Johns Hopkins School of Medicine

1987: Tutor and grading assistant: Biochemistry and Metabolism (medical and graduate student course; approx. 120 students)

1990: Discussion leader: Biochemistry and Metabolism (10 students)

1994: Teaching Assistant, Cells and Tissues (medical student course; approx. 140 students)

University of Pittsburgh

1995: PBL Facilitator: Cell Structure, Metabolism, and Nutrition 11/96 (3 contact hours; 9 students)

1996: Discussion Leader: Graduate Histology 5/96 (2 contact hours; 2 students) PBL Facilitator: Cell Structure, Metab., and Nutrition 10/96-11/96 (18 contact hours; 9 students)

1997: Lecturer: Structure, Function, and Devt. of Specialized Tissue 1/97 (2 lectures; ~140 students) PBL Facilitator: Structure, Function, and Devt. of Specialized Tissue 1/97 (3 contact hours; 9 students) PBL Facilitator: Introduction to Being a Physician 8/97 (9 contact hours; 10 students) PBL Facilitator: Cell Structure, Metabolism, and Nutrition 10/97-11/97 (18 contact hours; 10 students) Conference Leader: Foundations of Biomedical Science course 10/97 (18 contact hours; 6 students)

1998: Lecturer: Structure, Function, and Devt. of Specialized Tissue 1/98 (2 lectures; ~140 students) PBL Facilitator: Structure, Function, and Devt. of Spec. Tissue 1/98 (3 contact hours; 9 students) Laboratory Instructor: Structure, Function, and Devt. of Specialized Tissue 1/98 (2 contact hours; ~140 students) Co-Director: Cell Biology and Physiology Graduate Student Journal Club 1/98-6/98 (26 contact hours; 8 students) Lecturer: Foundations of Biomedical Science 10/98 (2 lectures; 29 students) Conference Leader: Foundations of Biomedical Science 10/98 (20 contact hours; 7 students) PBL Facilitator: Cell Structure, Metab., and Nutrition 10/98-11/98 (12 contact hours; 8 students)

1999: Lecturer: Structure, Function, and Devt. of Specialized Tissue 1/99 (2 lectures; ~140 students) PBL Facilitator: Structure, Function, and Devt. of Spec. Tissue 1/99 (6 contact hours; 8 students) Laboratory Instructor: Structure, Function, and Devt. of Specialized Tissue 1/99 (2 contact hours; approx. 140 students) Co-Director and Facilitator: Reg. of Membrane Traffic 5/99-8/99 (22 contact hours; 9 students) Lecturer: Foundations of Biomedical Science 10/99 (2 lectures; 41 students) Conference Leader: Found. of Biomedical Science 10/99-11/99 (20 contact hours; 8 students) PBL Facilitator: Cell Structure, Metabolism, and Nutrition 11/99 (18 contact hours; 9 students)

2000: Lecturer: Structure, Function, and Devt. of Specialized Tissue 1/00 (2 lectures; ~140 students) PBL Facilitator: Structure, Function, and Devt. of Spec. Tissue 1/00 (6 contact hours; 8 students) Lecturer: Graduate Histology 5/00 (1 lecture; 3 students) Lecturer: Regulation of Membrane Traffic 7/00-8/00 (2 lectures; 4 students) Co-Director and Facilitator, Reg. of Membrane Traffic 5/00-8/00 (22 contact hours; 4 students) PBL Facilitator: Introduction to Being a Physician 8/00 (10 contact hours) Lecturer: Foundations of Biomedical Science 10/00 (3 lectures) Conference Leader: Foundations of Biomedical Science 10/00-11/00 (16 contact hours) PBL Facilitator: Cell Structure, Metabolism, and Nutrition 11/00 (6 contact hours) Mentor and Facilitator: Research Basis of Medical Knowledge (10/00; 1.5 contact hours)

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2001: Lecturer: Structure, Function, and Devt. of Specialized Tissue 1/01 (1 lecture; ~140 students) Lecturer: Cell Biology of Normal and Disease States 4/01 (2 lectures; 9 students) Discussion Leader: Cell Biology of Normal and Disease States 4/01 (4 contact hours) Lecturer: Regulation of Membrane Traffic 8/01 (1 lecture; 5 students) Co-Director and Facilitator: Reg. of Membrane Traffic 5/01-7/01 (14 contact hours; 5 students) Lecturer: Renal Fellows Conference 8/01 (1 lecture) Lecturer: Graduate Histology course 8/01 (1 lecture; 1 student) Lecturer: Foundations of Biomedical Science 10/01 (3 lectures; ~40 students) Conference Leader: Found. of Biomedical Science 10/01-11/01 (18 contact hours; 8 students)

2002: Co-Director and Facilitator: Reg. of Membrane Traffic 1/02-4/02 (7 contact hours; 3 students) Lecturer: Structure, Function, and Devt. of Specialized Tissue 2/02 (2 lectures; ~140 students) Lecturer: Cell Biology of Normal and Disease States 2/02 (2 lectures; 11 students) Discussion Leader: Cell Biology of Normal and Disease States 2/02 (4 contact hours) Mentor and Facilitator: Research Basis of Medical Knowledge 3/02 (1.5 contact hours) Lecturer: Renal Fellows Conference 9/02 (1 lecture) Lecturer: Graduate Histology 9/02 (1 lecture; 5 students) Lecturer: Foundations of Biomedical Science 10/02 (2 lectures; ~45 students) Conference Leader: Found. of Biomedical Science 10/02-11/02 (16 contact hours; 7 students) PBL Facilitator: Cell Structure, Metabolism, and Nutrition 11/02 (1.5 contact hours)

2003: Lecturer: Cell Biology of Normal and Disease States 1/03-2/03 (2 lectures; 11 students) Discussion Leader: Cell Biology of Normal and Disease States 2/03 (4 contact hours) Lecturer: Structure, Function, and Devt. of Specialized Tissue 2/03 (2 lectures; ~140 students) Co-Director and Facilitator: Reg. of Membrane Traffic 5/03-8/03 (12 contact hours; 13 students) Lecturer: Foundations of Biomedical Science 10/03 (3 lectures; ~35 students) Conference Leader: Found. of Biomedical Science 10/03-11/03 (14 contact hours; 8 students) Facilitator: Medical School Journal Club 12/03 (approx. 20 students)

2004: Lecturer: Structure, Function, and Devt. of Specialized Tissue 2/04 (2 lectures; ~140 students) Lecturer: Cell Biology of Normal and Disease States 4/04-2/04 (2 lectures; 9 students) Discussion Leader: Cell Biology of Normal and Disease States 4/04 (4 contact hours; 9 students) Co-Director and Facilitator: Reg. of Membrane Traffic 5/04-8/04 (12 contact hours; 14 students) Lecturer: Foundations of Biomedical Science 10/04 (2 lectures; ~50 students) Conference Leader: Foundations of Biomed. Science 10/04-11/04 (18 contact hours; 8 students)

2005: Lecturer: Cell Biology of Normal and Disease States 2/05 (2 lectures; 7 students) Discussion Leader: Cell Biology of Normal and Disease States 2/05 (4 contact hours; 7 students) Co-Director and Facilitator: Reg. of Membrane Traffic 5/05-8/05 (6 contact hours; 7 students) Lecturer: Foundations of Biomedical Science 10/05 (3 lectures; ~50 students) Conference Leader: Foundations of Biomed. Science 10/05-11/05 (16 contact hours; 7 students)

2006: Lecturer: Cell Biology of Normal and Disease States 2/06 (2 lectures; 6 students) Discussion Leader: Cell Biology of Normal and Disease States 2/06 (4 contact hours; 6 students) Lecturer: Molecular Medicine 8/06 (1.5 contact hours; 11 students) Discussion Leader: Molecular Medicine 8/06 (1.5 contact hours; 11 students) Lecturer: Approaches in Molecular Biology 10/06 (2 contact hours; 5 students) Discussion Leader: Approaches in Molecular Biology 10/06 (3 contact hours; 5 students) Lecturer: Foundations of Biomedical Science 10/06 (2 lectures; ~40 students)

2007: Lecturer: Cell Biology of Normal and Disease States 2/07 (2 lectures; 6 students) Discussion Leader: Cell Biology of Normal and Disease States 2/07 (4 contact hours; 6 students) Co-Director and Facilitator: Reg. of Membrane Traffic 5/07-8/07 (4 contact hours; 11 students) Lecturer: Approaches in Molecular Biology 10/07 (2 contact hours; 5 students) Discussion Leader: Approaches in Molecular Biology 10/07 (3 contact hours; 5 students) Lecturer: Cell and Tissue Physiology 10/07 (1 contact hour; ~120 students) Lecturer: Foundations of Biomedical Science 11/07 (3 lectures; ~30 students)

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2008: Lecturer: Cell Biology of Normal and Disease States 2/08-3/08 (2 lectures; 5 students) Discussion Leader: Cell Biol. of Normal and Dis. States 2/08-3/08 (4 contact hours; 5 students) Discussion Leader: MSTP Professional Development Course 8/08 (2 contact hours; 5 students) Lecturer: Cellular and Pathologic Basis of Disease 10/08 1 contact hour; ~120 students) Lecturer: Approaches in Molecular Biology 10/08 (2 contact hours; 4 students) Discussion Leader: Approaches in Molecular Biology 10/08 (2 contact hours; 4 students) Lecturer: Foundations of Biomedical Science 11/08 (2 lectures; ~40 students)

2009: Lecturer: Cell Biology of Normal and Disease States 2/09-3/09 (1 lecture; 6 students) Discussion Leader: Cell Biol. of Normal and Dis. States 2/09-3/09 (4 contact hours; 6 students) Co-Director and Facilitator: Reg. of Membrane Traffic 5/09-8/09 (4 contact hours; 12 students) Facilitator: Cultural Diversity, Awareness, Acceptance, Inclusion 8/13/09 (1 hour; 11 students) Discussion Leader: Making the Most of Mentoring 10/09 (2 contact hours; 6 students) Lecturer: Cellular and Pathologic Basis of Disease 10/09 1 contact hour; ~120 students) Lecturer: Approaches in Molecular Biology 10/09 (2 contact hours; 5 students) Discussion Leader: Approaches in Molecular Biology 10/09 (2 contact hours; 5 students) Lecturer: Foundations of Biomedical Science 11/09 (3 contact hours; ~20 students)

2010: Moderator, PIMB Journal Club, 1/10-2/10 (3 sessions; ~15 students) Lecturer: Approaches in Molecular Biology 10/10 (3 contact hours; 5 students) Discussion Leader: Approaches in Molecular Biology 10/10 (3 contact hours; 5 students) Lecturer: Foundations of Biomedical Science 12/10 (2 contact hours; ~30 students)

2011: Discussion Leader: Cell Biol. of Normal and Dis. States 2/11 (2 contact hours; 7 students) Co-Director and Facilitator: Reg. of Membrane Traffic 5/11-8/11 (4 contact hours; 10 students) Lecturer: Approaches in Molecular Biology 10/11 (4 contact hours; 4 students) Discussion Leader: Approaches in Molecular Biology 10/11(2 contact hours; 4 students) Lecturer: Foundations of Biomedical Science 11/11-12/11 (3 contact hours; ~30 students)

2012: Moderator, PIMB Journal Club, 2/12 (2 contact hours; ~14 students) Lecturer: Approaches in Molecular Biology 10/12 (2 contact hours; 4 students) Discussion Leader: Approaches in Molecular Biology 10/12 (4 contact hours; 4 students) Lecturer: Foundations of Biomedical Science 11/12 (2 contact hours; ~25 students)

2013: Facilitator: Cultural Diversity, Awareness, Acceptance, Inclusion 8/9/13 (1 hour; 9 students) Lecturer: Foundations of Biomedical Science 11/13 (2 contact hours; ~30 students)

2014: Guest Lecturer: Epithelial Pathobiology, Vanderbilt University 4/14 (2 contact hours) Facilitator: Regulation of Membrane Traffic 8/14 (2 contact hours; 12 students) Facilitator: Cultural Diversity, Awareness, Acceptance, Inclusion 8/15/14 (1 hour; 8 students) Lecturer: Foundations of Biomedical Science 11/17/14 (2 contact hours; ~30 students)

2015: Moderator, PIMB Journal Club, 1/29/15 (1 session; 4 students) Lecturer: Foundations of Biomedical Science 12/1/15 (2 contact hours; ~30 students)

2016: Lecturer: Foundations of Biomedical Science 11/11/16 (2 contact hours; ~30 students) Facilitator: Regulation of Membrane Traffic 8/4/16 (2 contact hours; 10 students)

2017: Lecturer: Foundations of Biomedical Science 11/9/17 (2 contact hours; ~30 students)

2018: Lecturer: Foundations of Biomedical Science 11/6/18 (2 contact hours; ~30 students)

2019: Facilitator: Regulation of Membrane Traffic 7/18/19 (2 contact hours; 7 students) Lecturer: Foundations of Biomedical Science 11/1/19 (2 contact hours; ~25 students)

2020: Lecturer: Foundations of Biomedical Science 10/27/20 (2 contact hours; ~20 students)

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Students and Fellows supervised

High school Satvik Rangaraj (1996) Francisco Carattino (2014) Mona Gerges (2020-)

Undergraduate Jamie Popovich (1998-1999); SURP student; University of Pittsburgh, Pittsburgh, PA Sara Jackson (1999); SURP student; Allegheny College, Meadville, PA Mark Miedel (2001); SURP student; Penn State University, State College, PA Paul Whiteside (2002); SURP student; St. Vincent's College, Latrobe, PA Robert Hashimoto (2003); NSF CAEC student; Univ. of Pittsburgh. Pittsburgh, PA Tyra Hudgens (2003); QUEST student; University of Pittsburgh, Pittsburgh, PA Rena Xu (2004); NSF CAEC student; Harvard University, Cambridge, MA Anna Mari Lone (2005); NSF CAEC student; Amherst University, Amherst, MA Simone Costa (2009-2012); Carnegie-Mellon University, Pittsburgh, PA Bailey Moorhead (2009-2011); University of Pittsburgh, Pittsburgh, PA Brianne Docter (2011); SURP student, Grand Valley State University, Allendale, MI Yash Agarwal (2017); FER student, University of Pittsburgh, Pittsburgh, PA Makenzi Patterson (2020); University of Pittsburgh, Pittsburgh, PA

Predoctoral rotation students Steven Truschel, Cell Biology and Physiology Training Program (1996) Lazar Vujanovic, Interdisciplinary Biomedical Training Program (1998-1999) Julia Liachenko, Interdisciplinary Biomedical Training Program (2002-2003) Eric Rubenstein, Interdisciplinary Biomedical Training Program (2004) Yi Zhou, Interdisciplinary Biomedical Training Program (2005) Carolyn Kitchens, Interdisciplinary Biomedical Training Program (2006) Varsha Shridhar, Interdisciplinary Biomedical Training Program (2006) Mandovi Chatterjee, Program in Integrative Molecular Biology (2007) Haiyun Zheng, Program in Integrative Molecular Biology (2009) Zankruti Dave, Program in Integrative Molecular Biology (2009) Melanie Warnes, Program in Integrative Molecular Biology (2010) Samantha Seaberg, Interdisciplinary Biomedical Training Program (2010) Du Yuan, Xiangya University (2013) Ademayowa Balogun, Interdisciplinary Biomedical Training Program (2015) Andrew Gutierrez, Medical Scientist Training Program (2017) Xueqi Wang, Xiangya University (2017) Shenyu Sun, Integrative Systems Biology Program (2018) Michael McEnroe, Human Genetics Graduate Program (2019) Kayla Troutman, Interdisciplinary Biomedical Training Program (2019) Lei Zhang, Xiangya University (2019) Sripriya Raja, Interdisciplinary Biomedical Training Program (2019)

Doctoral students Mark Ellis, CBMP Program (1999-2006) Director of Scientific Strategy, Conisus, New York, NY Beth Potter MVM Program (2001-2006) Associate Professor, Penn State Univ. Behrend Campus, Erie, PA Christopher Guerriero, CBMP Program (2004-2008) Res. Assistant Professor, University of Pittsburgh Mark Miedel, CBMP Program (2004-2008) Research Associate, University of Pittsburgh Shanshan Cui, CBMP Program (2006-2010) Clinical Trial Manager, Medpace, Cincinnati, OH Di Mo, PIMB (2007-2012) Manager, Global Distribution and Strategic Partnerships at 10X Genomics, San Francisco, CA Christina Szalinski, CBMP Program (2009-2013) Freelance science writer, Philadelphia, PA Anatália Labilloy, MD, Human Genetics Graduate Program (2011-2015) Assistant Professor, University of Florida College of Medicine, Jacksonville, FL Venkatesan Raghavan, Program in Integrative Molecular Biology (2012-2015) Director, Bayer Curr cu um V tae Ora A. We sz

Pharmaceuticals, Whippany, NJ Megan Eshbach (Gliozzi), Human Genetics Graduate Program, (2014-2019) ORISE Postdoctoral Fellow, FDA Katherine Shipman, Integrative Systems Biology Program (2015-) Qidong Ren, Tsinghua Scholars Program (2017-2019), Medical Student, Tsinghua Univ., Beijing, PRC

Postdoctoral fellows Xiaosui Jiang, PhD (1996-98) Senior Scientist, Bristol-Myers Squibb, Newtown, PA Kelly Weixel, PhD (2001-2006) Associate Prof., Washington and Jefferson College, Washington, PA Kerry Cresawn, PhD (2006-2007) Assistant Prof and Director, Center for STEM Education and Outreach, James Madison University, Harrisonburg, VA Beth Potter, PhD (2006-2007) Associate Prof., Penn State University, The Behrend College, Erie, PA Polly Mattila, PhD (2007-2011) Research Scientist, Division of Endocrinology and Metabolism, University of Pittsburgh Robert Youker, PhD (2009-2014) Associate Prof., Western Carolina University, Cullowhee, NC Osama Alshogran, PhD (2014-2015) Assistant Prof., Jordan Univ of Science and Technol, Irbid, Jordan Sohinee Bhattacharyya, PhD (2015-2016) Postdoctoral Fellow, Oregon Health Sciences University, Portland, OR

Medical fellows and residents Jan Levora, MD (1999-2000) Savita Mohan, MD (2002-2005) Sonia Bynum, MD (2008-2009) Jingjing Zhang, MD (2013-2014) Amandeep Kaur, MD (2015-2016)

Trainee grants and awards

Trainee grants NIH 5T32DK061296 Renal and Epithelial Biology Training Program "Role of phosphatidylinositol metabolism in biosynthetic traffic in polarized epithelial cells", 7/1/2002-6/30/2004 (Kelly Weixel)

NIH NRSA F32 DK 065408 “ENaC trafficking in renal epithelial cells”; 7/2003-6/2005 (Savita Mohan)

AHA pre-doctoral fellowship “Mechanisms of glycan-dependent apical sorting”; 7/2004-6/2006 (Beth Potter)

NIH 5T32DK061296 Renal and Epithelial Biology Training Program "Role of phosphatidylinositol metabolism in polarized biosynthetic traffic" 7/1/2004-6/30/2005 (Christopher Guerriero)

AHA pre-doctoral fellowship “Role of PIP2 in Biosynthetic Sorting in Polarized MDCK Cells”; 7/2006- 6/2008 (Christopher Guerriero)

AHA post-doctoral fellowship “Regulation of apical membrane traffic in MDCK cells”; 7/2006-6/2008 (Kerry Cresawn)

NIH 5TL1RR 024155 Clinical and Translational Science Institute pre-doctoral fellowship “The role of mucolipin-1 in the pathogenesis of the lysosomal storage disease mucolipidosis type IV” 7/2007-6/2008 (Mark Miedel)

NIH 5T32DK061296 Renal and Epithelial Biology Training Program "Modulation of polarized endocytosis by phosphatidylinositol metabolism" 7/1/2009-6/30/2010 (Christina Szalinski)

Howard Hughes Medical Institute Summer Scholar award; 5/31/11-8/4/11 (Simone Costa)

AHA 12SDG8960000 American Heart Association Scientist Development Grant “Apical sorting mechanisms in renal epithelial cells”; 1/1/12-12/31/15 (Robert Youker)

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AHA 12SDG12040003 American Heart Association Scientist Development Grant “Endolyn/CD164 and CXCR4 function in kidney Repair”; 7/1/12-6/30/16 (Polly Mattila)

NIH 5T32DK061296 Renal and Epithelial Biology Training Program "Flow-Stimulated Endocytosis in Proteinuric Diseases" 9/1/15-8/31/16 (Megan Eshbach)

NIH TL1TR001858 Clinical and Translational Science Institute pre-doctoral fellowship “Tubular proteinuria and vitamin D metabolism in Sickle Cell Disease” 9/1/17-8/31/19 (Megan Eshbach) ASN Foundation for Kidney Research Pre-Doctoral Fellowship Award “Megalin traffic in Dent disease” 7/1/18-6/30/19 (Katherine Shipman) NIH F31DK121394 “Megalin Traffic in Dent Disease” 7/1/19-6/30/22 (Katherine Shipman) Travel awards to trainees American Society of Nephrology Travel Award to attend the American Physiological Society Conference “Aldosterone and ENaC: From Genetics to Physiology”, Banff, Canada, Sept. 10-14, 2003. (Savita Mohan)

Society for Glycobiology Travel Award to attend Glycobiology 2005, Boston, MA, Nov. 9-12, 2005. (Beth Potter)

American Society for Cell Biology Travel award to attend the 46th annual ASCB meeting, San Diego CA, Dec. 9-13, 2006 (Christopher Guerriero)

NIH NRSA F32 DK 082109 “Intracellular Route of Secreted Apical Proteins In Renal Epithelial Cells” 7/2008-6/2011 (Polly Mattila)

American Society for Cell Biology Travel award to attend the 48th annual ASCB meeting, San Diego CA, Dec. 13-17, 2008 (Shanshan Cui)

American Society for Cell Biology Travel award to attend the 50th annual ASCB meeting, Philadelphia, PA, Dec. 11-15, 2010 (Di Mo)

American Society for Cell Biology Travel award to attend the 51st annual ASCB meeting, Denver, CO, Dec. 3-7, 2011 (Robert Youker)

American Society for Cell Biology Travel award to attend the 53rd annual ASCB meeting, New Orleans, LA, Dec. 14-18, 2013 (Venkatesan Raghavan)

American Society for Cell Biology Travel award to attend the 53rd annual ASCB meeting, New Orleans, LA, Dec. 14-18, 2013 (Anatália Labilloy)

American Society of Nephrology Kidney STARS program award to attend ASN Kidney Week, Philadelphia, PA, Nov 12-16, 2014 (Anatália Labilloy)

ASCB and Keck Graduate Institutes “Managing Science in the Biotech Industry: An Intensive Course for PhD Students and Postdocs”, July 12-24, 2015 (Venkatesan Raghavan)

American Physiological Society Travel award to attend 2018 Experimental Biology meeting, San Diego CA, April 21-25 (Megan Eshbach)

American Physiological Society Travel award to attend 2018 Experimental Biology meeting, San Diego CA, April 21-25 (Katherine Shipman)

Burroughs Wellcome Fund Trainee Travel Award to attend Translational Science 2019, Washington DC, March 5-8 (Megan Gliozzi)

American Physiological Society Travel award to attend 2019 Experimental Biology meeting, Orlando, FL April 6-9 (Katherine Shipman) Curr cu um V tae Ora A. We sz

American Physiological Society Travel award to attend the 2019 APS/ASN Conference: Control of Renal Function in Health and Disease, Charlottesville, VA, June 23-27 (Katherine Shipman)

American Physiological Society Travel award to attend 2020 Experimental Biology meeting, San Diego, CA, April 4-7 (Katherine Shipman)

Other trainee awards Stephen L. Phillips award for best graduate student paper, 2014 (Venkatesan Raghavan) Integrative Systems Biology Symposium best poster award, 2015 (Venkatesan Raghavan) American Physiological Society Renal Section Predoctoral Excellence in Research Award, 2015 (Venkatesan Raghavan) Graduate School of Public Health Dean’s Day poster award, 2015 (Anatália Labilloy) Department of Human Genetics Robert E. Ferrell Award for Excellence, 2015 (Anatália Labilloy) Department of Medicine Research Day graduate student poster award, 2015 (Anatália Labilloy) First Place, Pitt Health Innovation Case Competition, 2015 (Venkatesan Raghavan) Oral Presentation, Department of Medicine Research Day, 2016 (Megan Eshbach) Second Place, Acute Kidney Injury Symposium oral abstract presentations 2017 (Megan Eshbach) Finalist, American Physiological Society Epithelial Transport Group poster awards, 2020 (Katherine Shipman; meeting cancelled due to Covid-19) Department of Human Genetics Outstanding Graduate Student Award, Doctoral Level, 2020 (Megan Gliozzi)

Student Committees and Mentoring Comprehensive Examination Committees Som-Ming Leung (1999; chair); Fei Sun (2000; chair); Steven Truschel (2000; chair); Asli Oztan (2001); Stephanie Goode (2001);Raul Rojas (2002; chair); Christopher Lewarchik (2002); Peter Keyel (2004); Elena Balestreire (2004); Roxana Teisanu (2005; chair); Justin Caserta (2006); Ethan Block (2006); Hilaire Lam (2008); Lauren Brilli (2012); Christine Klemens (2013); Celestino Velásquez (2014); Julia Loose (2018); Jonathan Klonowski (2019); Laura Bahr (2020)

Thesis Committees Som-Ming Leung (2000-2002); Lazar Vujanovic (2000-2006); Steven Truschel (2001-2003); Asli Oztan (2001-2007); Stacy Hrizo (2005-2008); Marianna Tsvitov (2005); Eric Rubenstein (2005-2008); Jing Jin (2006-2007); John Jennings (2006-2008); Angela Erazo (2006-2010); L. Michael Thomas (2007-2011); Hilaire Lam (2008-2011); Alex Kolb (2008-2013); Grace Colletti (2009-2011); Dan Wang (2009-2010); Sandeep Prakasam (2010-2013); Elizabeth Axford-Delorme (2011-2013, chair); Prerna Grover (2012- 2015); Pooja Gandhi (2013-2014); Chelsea Merkel (2016-2019, chair); Jonathan Klonowski (2019-2020, chair); Laura Bahr (2020-, chair); Rachel Wills (2020-)

External examiner, PhD defenses Florencia Schapiro, University of Toronto, Dept. of Biochemistry (2001); Amy Mehta, Carnegie-Mellon University, Biology Sciences (2002); Sapna Puri, Carnegie-Mellon University, Biology Sciences (2003); Rajalaxmi Natarajan, Carnegie-Mellon University, Biology Sciences (2005); Timothy Feinstein, Carnegie- Mellon University, Biology Sciences (2008); Shanna Bowersox Bowman, Carnegie-Mellon University, Biology Sciences (2015); Swati Venkat, Carnegie-Mellon University, Biology Sciences (2017)

First year graduate student mentoring 1997-2004: 23 students

Postdoc mentoring committees Ken Walker, PhD (2012-2014) Pediatric Nephrology, Children’s Hospital Mohammad al-Bateineh (2012-2014) Renal-Electrolyte Div, University of Pittsburgh

Fellow mentoring committees Tenille Webb, MD (2013-2014) Pediatric Nephrology, Children’s Hospital

Faculty mentoring Curr cu um V tae Ora A. We sz

Yan Jing, MD (2007-2009) Asst. Professor, Pulmonary and Critical Care Medicine Division Bryan McVerrey, MD (2007-2013) Asst. Professor, Pulmonary and Critical Care Medicine Division Yvonne Chan, MD (2007-2013) Asst. Professor, Pulmonary and Critical Care Medicine Division Erin Kershaw, MD (2008-2013) Asst. Professor, Division of Endocrinology and Metabolism Geetha Chalasani, MD (2007-2011) Asst. Professor, Renal-Electrolyte Division Arohan Subramanya, MD (2009-2012) Asst. Professor, Renal-Electrolyte Division Jaideep Behari, MD (2009-2013) Asst. Professor, Gastroenterology Division Kristen Veraldi, MD (2010-2014) Asst. Professor, Pulmonary and Critical Care Medicine Division Marie Menke, MD (2011-2013) Asst. Professor, Obstetrics and Gynecology Department Fernando Holguin, MD (2011-2012) Asst. Professor, Pulmonary and Critical Care Medicine Allyson O’Donnell, PhD (2012-2014) Research Assistant Professor, Dept. of Cell Biology Mandy McGeachy, PhD (2013-2015) Asst. Professor, Rheumatology Division Agnieszka Swiatecka-Urban, MD (2013-2015) Asst. Professor, Pediatric Nephrology Sonya Borrero, MD (2014-2015) Asst. Professor, General Internal Medicine Molly Conroy, MD (2014-2015) Assoc. Professor, General Internal Medicine Kathleen McTigue, MD (2014-2015) Assoc. Professor, General Internal Medicine Susan Zickmund, MD (2015-2016) Assoc. Professor, General Internal Medicine Shujie Shi, MD (2015-) Research Instructor, Renal-Electrolyte Division

RESEARCH:

Current grant support Grant number Title Role/ % effort Years Source/ total costs P30 DK079307 Pittsburgh center for kidney research Associate Director, 8/17- NIH 5% (TR Kleyman) 7/23 $2,967,970 R01-DK118726 Proximal tubule endocytosis in PI, 30% 4/19- NIH normal and nephrotic kidneys 3/23 $1,817,715 R01-DK125049 Endocytic pathway dysfunction in PI, 35% 3/20- NIH Dent disease 2/25 $2,342,752

Pending grant support

Prior grant support Grant number Title Role/ % effort Years Source/$ R01-DK100357 Apical protein sorting in renal PI, 30% 7/14- NIH epithelial cells 1/19 $1,339,800 R01-DK101484 Flow-stimulated endocytosis in the PI, 30% 12/14- NIH proximal tubule 11/18 $1,377,579 P30 DK079307 Pittsburgh center for kidney research Associate Director, 8/13- NIH 10% (TR Kleyman) 7/18 $6,042,000 NA Vascular Medicine Institute Pilot: PI, 1% 7/16- VMI, VinDCate: Vitamin D in sickle cell 6/17 $25,000 patients NA Evaluation of proximal tubule cell PI, 1% 4/16- Dialysis Clinic, culture models to study membrane 3/17 Inc. trafficking $61,552 S10-OD021627 Integrated perfusion and confocal PI, 0% 5/16- NIH imaging system 4/17 $478,554 NA Role of OCRL1 in flow sensing by PI, 5% 12/14- Lowe proximal tubule cells 11/15 Syndrome Assn $25,000 2011129 Junior Scholar Awards program Program director, 1/12- Doris Duke 3% 8/15 Charitable Fdn $72,500 NA P30 pilot: How does ciliary bending PI, 0% 8/14- NIH P30

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regulate endocytosis in the proximal 7/15 $30,000 tubule? NA Role of OCRL1 in flow sensing by PI, 5% 9/13- Lowe proximal tubule cells 8/14 Syndrome Assn $25,000 NA Apical traffic in renal epithelial cells PI, 20% 5/13- Dialysis Clinic, 6/14 Inc. $160,000 R01-DK084184 Regulation of V-ATPase by protein Co-investigator, 3% 7/09- NIH kinase A and AMP-activated kinase (N Pastor-Soler) 6/14 $1,510,000 P30-DK079307 Pittsburgh center for kidney research Associate Director, 9/08- NIH 5% (TR Kleyman) 7/13 $4,443,995 NA P30 pilot: Endolyn modulation of PI, 0% 7/11- NIH P30 CXCR4 signaling in recovery from 6/13 $40,000 kidney injury R01-DK064613 Regulation of polarized traffic by PI- PI, 30% 5/09- NIH metabolizing enzymes 4/13 $1,307,689 R01-DK54407 Regulation of apical traffic in renal PI, 30% 9/07- NIH epithelial cells 7/12 $1,599,598 R01-HD058577 TRPML1 role in lysosomes Co-investigator, 5% 9/09- NIH (K Kiselyov) 8/12 $1,125,000 R01-DK57718 Trafficking and regulation of the Co-investigator, 5% 1/07- NIH epithelial Na+ channel (JP Johnson) 12/11 $1,238,200 R01-DK054407 Regulation of apical traffic in renal PI 1/10- NIH 12S1 epithelial cells 12/10 $99,452 NA OCRL function in renal epithelial PI, 5% 9/07- Lowe membrane traffic 8/09 Syndrome Assn $45,000 R01-DK064613 Regulation of polarized traffic by PI- PI, 30% 7/04- NIH metabolizing enzymes 6/08 $1,257,432 9R56AI073261 Cellular and molecular biology of Co-investigator, 5% 9/07- NIH EIAV replication (RC Montelaro) 9/08 $200,000 NA Polarized membrane traffic in kidney PI 5/04- Common- cells 4/08 wealth of PA $304,341 R01-DK54407 Regulation of apical traffic in renal PI, 40% 9/03- NIH epithelial cells 8/07 $1,127,371 R01-DK57718 Trafficking and regulation of the Co-investigator, 3/02- NIH epithelial Na+ channel 50% 2/06 $977,645 (JP Johnson) R01-CA49296 Cellular and molecular biology of Co-investigator, 5% 4/02- NIH EIAV replication (RC Montelaro) 7/06 $1,175,658 NA Mechanism of Na+ channel PI, 20% 9/99- Cystic Fibrosis regulation by CFTR 8/01 Foundation $60,000 R01-DK54407 Golgi/endosome pH in renal PI, 50% 9/98- NIH epithelial protein traffic 8/03 $755,000 96P0 Protein traffic in CF cells PI, 40% 7/97- Cystic Fibrosis 6/00 Foundation $225,000 NA Use of influenza M2 protein to PI 9/98- Emma and selectively perturb organelle pH 8/99 Samuel Winters Fdn, $7,500 NA Trafficking of influenza M2 protein in PI, 10% 7/96- Compet Med Curr cu um V tae Ora A. We sz

polarized epithelial cells 6/97 Res Fund, UPMC, $17,800 P0096 Protein targeting and glycosylation in PI, 30% 4/96- Cystic Fibrosis CF cells 3/97 Foundation $32,560

Seminars and invited lectures University of Pittsburgh Department of Cell Biology and Physiology (4/1997) Department of Pharmacology (11/1997) Young Investigators Dinner, Department of Medicine (1/1999) Division of Infectious Diseases (2/1999) University of Pittsburgh School of Medicine Board of Visitors (12/2001) Local Traffic 2002: 1st Annual Pittsburgh Symposium on Intracellular Membrane/Protein Traffic (5/2002) MD-PhD Seminar Series (5/2004) Department of Ophthalmology (5/2004) Department of Biological Sciences (10/2006) Department of Pediatrics (3/2007) Program in Integrative Molecular Biology Annual Retreat (9/2007) Science 2008 Spotlight Session: Cellular Traffic Management and Molecular Signposts (10/2008) Local Traffic 2011: 10th Annual Pittsburgh Symposium on Intracellular Membrane/Protein Traffic (5/2011) Pittsburgh-Cleveland Kidney Research Meeting (9/2014) Microbiology and Molecular Genetics Department (4/2015) Molecular Medicine Research Seminar, Department of Pediatrics (5/2015) Vascular Medicine Institute Sickle Cell Research Conference (2/2017) Department of Cell Biology Annual Retreat (9/2017)

External seminars and symposia American Society for Cell Biology Minisymposium, Denver, CO (1992) KAST Intl. Workshop on Molecular Recognition in Biomaterials, Kawasaki, Japan, (1992) University of North Carolina, Department of Medicine (Pulmonary), Chapel Hill, NC (1993) University of Pittsburgh, Renal-Electrolyte Division, Pittsburgh, PA (10/1994) Medical College of Pennsylvania, Department of Physiology, Philadelphia, PA (1994) National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD (1995) University of Connecticut, Department of Physiology and Neurobiology, Storrs, CT (1995) Carnegie-Mellon University, Department of Biology, Pittsburgh, PA (1997) Indiana University Medical School, Department of Medicine (Nephrology), Indianapolis, IN (1998) American Society of Nephrology Annual Meeting, Philadelphia, PA (1998) University of Pennsylvania, Department of Physiology, Philadelphia, PA (2000) Case-Western Reserve University, Department of Pediatrics, Cleveland, OH (2000) University of North Carolina, Cystic Fibrosis Center, Chapel Hill, NC (2000) American Society of Nephrology Annual Meeting, featured mini-lecture, Toronto, Canada (2000) North American Cystic Fibrosis Conference, Baltimore, MD (2000) Harvard Medical School, Nephrology Division, Massachusetts General Hospital, Boston, MA (2000) Hospital for Sick Children, Division of Cell Biology, Toronto, Canada (2001) Yale University, Department of Physiology, New Haven, CT (2001) Harden Conference “Dynamics of Membrane Traffic”, Ambleside, England (2002) University of Cambridge, Department of Cell Biology, Cambridge, England (2002) University of Southern California, Department of Pharmaceutical Sciences, Los Angeles, CA (2002) National Institutes of Health, Lab. of Kidney and Electrolyte Metabolism, NHLBI, Bethesda, MD (2003) Duquesne University, Department of Biological Sciences, Pittsburgh PA (2003) Emory University, Department of Physiology, Atlanta, GA (2004) Experimental Biology 2004 Symposium, Washington D.C. (2004) American Society of Nephrology 37th Annual Meeting Symposium, St. Louis, MO (2004) The Physiological Society Main Meeting symposium, London, England (2006) Vanderbilt University Medical School, Department of Surgery, Nashville, TN (2007) Cornell University, Department of Molecular Medicine, Ithaca, NY (2007) Curr cu um V tae Ora A. We sz

Johns Hopkins University School of Medicine, Department of Cell Biology, Baltimore, MD (2007) Johns Hopkins University School of Medicine, GI Core Center, Baltimore, MD (2007) Uniformed Services Univ. of the Health Sciences, Department of Pharmacology, Bethesda, MD (2008) Nephrogenic Diabetes Insipidus Foundation 6th Global Conference, Amelia Island, FL (2008) University of Kentucky Medical Center, Department of Toxicology, Lexington, KY (2008) Symposium on Mucolipin Function in Disease, Washington DC (2008) 11th International Conference on Lowe Syndrome, Orlando, FL (2008) ASN Advances in Research Conference, Philadelphia, PA (2008) Weill Cornell Medical College, Department of Cell and Developmental Biology, New York, NY (2008) Albert Einstein College of Medicine, Department of Developmental and Mol. Biol., New York, NY (2008) University of Louisville, Department of Medicine (Kidney Disease Program), Louisville KY (2009) National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD (2009) Telluride Conference on Epithelial Physiology and Cell Biology, Telluride, CO (2010) Johns Hopkins University School of Medicine Conte Digestive Diseases Basic and Translational Research Core Center Inaugural Symposium, Baltimore, MD (2012) UTSW O’Brien Kidney Core Research Center Lecture Series, Dallas, TX (2012) University of Alabama at Birmingham, Cell, Developmental and Integrative Biology (2013) Johns Hopkins University School of Medicine, Pharmacology and Molecular Sciences, Baltimore (2013) Nephrotic Syndrome Conference, Pittsburgh, PA (2014) Vanderbilt University, Department of Surgery, Nashville, TN (2014) Experimental Biology 2014 Symposium, San Diego, CA (2014) Emory University, Department of Physiology, Atlanta, GA (2014) Massachusetts General Hospital, Nephrology Division, Boston, MA (2016) Children’s Hospital of Pennsylvania, Department of Cellular Pathology, Philadelphia, PA (2016) Purdue University, Department of Biological Sciences, Lafayette, IN (2017) Experimental Biology 2018 Symposium, San Diego, CA (2018) APS/ASN Conference on Control of Renal Function in Health and Disease, Charlottesville, VA (2019) Kidney Week 2019 Symposium: Glomerular and Tubular Origins of Albuminuria, Washington DC (2019) Society for Experimental Biology and Medicine Symposium at Experimental Biology 2020, San Diego, CA (4/2020; cancelled due to Covid-19) IRICoR symposium on Lowe Syndrome, Montreal, Canada (5/2020; cancelled due to Covid-19)

Other research-related activities Symposia and Meetings Panelist, National Research Council Public Hearing on National Needs for Biomedical and Behavioral Research Personnel, Washington, D.C. (1993) Participant, National Research Council Convocation on Misconduct in Science, Washington, D.C. (1994) Panelist, “Career Opportunities for Biomedical Scientists” Johns Hopkins School of Medicine (1996) Roundtable Moderator, North American Cystic Fibrosis Foundation Conference (1997) Co-organizer, Epithelial Cell Biology Workshop, North American Cystic Fibrosis Conference, Baltimore, MD (2000) Organizer and Moderator, Cross-Sectional Symposium, American Physiological Society Annual Meeting, San Francisco, CA (4/2006) Symposium Organizer, The Physiological Society Main Meeting, London, England (7/2006) Moderator, Intracellular Trafficking Session, Advances in Research Conference, Philadelphia, PA (11/2008) Moderator, Novel Mechanisms in Renal Function and Blood Pressure Regulation Symposium, American Physiological Society Annual Meeting, Boston, MA (3/2015) Session chair, NIDDK meeting on ApoL1 and Kidney Disease, College Park, MD (6/2015)

Publication and grant reviews NIH study sections and board memberships General Medicine B, ad hoc (2002) Special Emphasis Panels (2003, 2004, 2007, 2008, 2009, 2012) Basic and Clinical Aspects of Cardiovascular, Respiratory, Blood, Digestive and Renal Systems (2004) Gastrointestinal, Renal, and Bone Pathophysiology (2004) Physiology and Pathobiology of Organ Systems (2005-2007) Curr cu um V tae Ora A. We sz

Membrane Biology and Protein Processing (2007) NHLBI Board of Scientific Counselors Site Review Meeting, ad hoc (2007, 2010) Cell and Molecular Biology of the Kidney regular member (2008-2011) Kidney Molecular Biology and Genitourinary Organ Development regular member (2011-2012) NIH NHLBI Board of Scientific Counselors (2014-2020) NIH CSR pilot study (2015) NIH Advisory Panel to Assess Study Sections (2019) NIH Director’s New Innovator Award (2019) NIH ZRG1 DKUS-P Conflicts in Nephrology (2020)

Other study sections National Science Foundation, Cell Biology (1998-1999) American Heart Association Mid-Atlantic Affiliate, Basic Cell & Molecular Biology (2007-2009) Vice Chair, Italian Telethon Foundation Scientific Committee (2015-2017; member since 2012) Italian Telethon Foundation Covid-19 related initiative (2020) External Reviewer National Science Foundation: Cell Biology (1999, 2002), Undergraduate Programs (2000), Cellular Organization (2004), Molecular and Cellular Biosciences (2010); Wellcome Trust (2000, 2005); Lowe Syndrome Association (2000, 2001); American Institute of Biological Sciences (2004); American Heart Association (2006); Qatar National Research Foundation (2009); NIH Scientific Conference Grants (2009); National Research Foundation of Korea (2013); Italian Telethon Foundation (2019)

University of Pittsburgh reviews UPMC Competitive Medical Research Fund (2008) CTSA Pilots Across the SPIRiT program (2012) Ri.MED Foundation Postdoctoral Program (2012)

Editorial board member American Journal of Physiology- Renal Physiology (2001-2007, 2020-present) American Journal of Physiology- Cell Physiology (2002-present) Physiological Reviews (Associate Editor, 2009-2017) Traffic (2012-2020) Frontiers in Membrane Traffic (review editor, 2013-present) Journal of the American Society of Nephrology (2018-present) Function (2020-present)

Peer review American Journal of Physiology- Cell Physiology; American Journal of Physiology- Renal Physiology; American Journal of Physiology- GI and Liver Physiology; American Journal of Respiratory Cell and Molecular Biology; Biochimica et Biophysica Acta; Biomicrofluidics; BMC Cell Biology; Cell Biochemistry and Biophysics; Cytokine; Cell Research; EMBO Journal; Experimental Cell Research; Experimental Lung Research; FASEB Journal; FEBS Journal; Frontiers in Cell and Developmental Biology; Frontiers Physiology; Glycobiology; Hepatology; Journal of the American Society of Nephrology; Journal of Biological Chemistry; Journal of Cell Biology; Journal of Cell Science; Journal of Child Science; Journal of Clinical Investigation; Journal of Pediatric Genetics; Journal of Visual Experimentation; Kidney International; Leukemia; Microbiology and Molecular Biology Reviews; Molecular Biology of the Cell; Molecular Genetics and Metabolism; Physiology; Proceedings of the National Academy of Science; Science Signaling; Scientific Reports; Targeted Proteins Database; Traffic; Trends in Cell Biology

Other meetings AAMC Mid-Career Women’s Professional Development Seminar, Washington D.C., July 19-22, 2003. AAMC Faculty Affairs Professional Development Conference, Tampa, FL, Jan. 24-27, 2004. Council of Graduate Studies Summer Workshop, San Juan, PR, June 11-14, 2004. AAMC Annual Meeting, Boston, MA, Nov. 5-10, 2004. Regional Postdoctoral Symposium “Building a Dynamic Postdoctoral Community”, University of Pittsburgh, Pittsburgh, PA, Oct. 8, 2004. McGowan Institute for Regenerative Medicine Scientific Retreat and Strategic Planning Session, Curr cu um V tae Ora A. We sz

Nemacolin Woodlands, PA, March 7-8, 2005. AAMC Faculty Affairs Professional Development Conference, Ottawa, Canada, July 30-Aug. 2, 2005. Allegheny County Medical Society Conference “Diversity in the Professions: Challenges and Solutions” Pittsburgh, PA June 2, 2006. AAMC Group on Faculty Affairs Professional Development Conference, San Diego, California, January 26-29, 2007. AAMC Annual Meeting, Washington DC, Nov. 2-7, 2007. AAMC Group on Faculty Affairs Professional Development Conference, Seattle, Washington, August 4-7, 2011. AAMC Group on Faculty Affairs and Group on Diversity and Inclusion Professional Development Conference, Indianapolis, Indiana, August 9-12, 2012. Developing Engaged and Creative Employees: Coaching Skills for Leaders, Pittsburgh, PA Sept 13-Oct 18, 2016.

Other research related service Pennsylvania Congressional Liaison Committee, member (2000-2005)

SERVICE:

Yale University Interviewer for Yale University Undergraduate Admissions Office (1988-1991)

Johns Hopkins School of Medicine Co-President and President, The Johns Hopkins Postdoctoral Association (1994-1995) Member, Medical School Council (1994-1995) Member, Joint Committee on Housestaff and Postdoctoral Programs (1994-1995) Symposium Co-Organizer “Career Opportunities for Biomedical Scientists” (1995)

University of Pittsburgh Graduate program and education activities: Chair, Student Evaluation and Progress Committee, Interdisciplinary Biomedical Graduate Program (1998-1999; member 1997-2001) Moderator, Graduate Student Rotation Presentations, Interdisciplinary Biomedical Graduate Program (1999) Founder and Director, Cell Biology and Molecular Physiology Summer Undergraduate Research Program (1998-2002) Curriculum Committee, Cell Biology and Molecular Physiology Graduate Program (2000-2002) Recruiting Committee, Cell Biology and Molecular Physiology Graduate Program (2000-2002) Summer Undergraduate Research Program Committee, Interdisciplinary Biomedical Graduate Program (2001-2002) Chair, Admissions Committee, Interdisciplinary Biomedical Graduate Program (2004-2005; Vice-Chair, 2003-2004; member, 2002-2005) Recruiting and Admissions Committee, Program in Integrative Molecular Biology (2005-2008; 2012-2013) Steering Committee, Program in Integrative Molecular Biology (2008-2012) Chair, Academic Affairs Committee, Program in Integrative Molecular Biology (2010-2012; Vice-Chair, 2008-2010) Advisory Committee, Cell Biology and Molecular Physiology Graduate Program (2010-present) Admissions Committee, Integrative Systems Biology Graduate Program (2014-2015) Externship Committee, Integrative Systems Biology Graduate Program (2015-present) Faculty Advisor, Distinguished Mentor Committee (2015, 2016)

Interviewer, Renal-Electrolyte Division Fellowship program (1998-1999, 2004-2005) Interviewer, Interdisciplinary Biomedical Graduate Program (1998-present) Interviewer, M.D. and M.D.-Ph.D. Admissions Committee (1999-2007) Interviewer, Program in Integrative Molecular Biology (2008-2014) Interviewer, Integrative Systems Biology Graduate Program (2016-present) Medical School Curriculum Vision Task Force (2001-2002) Foundations of Biomedical Science Course Advisory Committee (2002) Curr cu um V tae Ora A. We sz

School of Medicine Discussion Group on Postdoctoral Issues (2004) Clinical and Translational Research Certificate Advisory Group (2006-2007) Abstract and Poster Reviewer, Clinical and Translational Science Day (2007) Executive Steering Committee, Renal-Electrolyte Training Grant (2008-present) LCME Accreditation Committee: Institutional Setting (2010) Poster judge, Biomedical Graduate Student Association Symposium (2012-2014) Poster judge, Department of Medicine Research Day (2013-present)

Search committees: Cell Biology and Physiology Department Faculty Search Committee, (2001-2002; 2007-2008) McGowan Institute for Regenerative Medicine Faculty Search Committee, (2002-2003) Department of Medicine Chairman Search Committee (2005, 2010) Department of Cell Biology and Physiology Chairman Search Committee (2007-2008) Renal-Electrolyte Division Faculty Search Committee (2008-2009) Department of Medicine Division of Rheumatology Search Committee (2020)

Other committees and activities: Local Traffic Annual Symposium on Intracellular Membrane Traffic (2002-; Chair, 2011-2013) University of Pittsburgh Provost’s Postdoctoral Policies Committee (2003-2005) Mellon and Dickson Prize Committee (2000-2010; 2016-) Standing Committee for Tenured Faculty Promotions and Appointments (2007-2008) Elected Member-at-Large, School of Medicine Executive Committee (2008-2011) Science 2013 Spotlight Session moderator, Cellular Traffic Management (2013) Provost’s Advisory Committee on Women’s Concerns (2014-2015) Executive Committee, University of Pittsburgh Liver Center (2016-)

Career Development of Health Science Professionals Panels and discussions Getting to the Payline: Writing Successful Fellowship Applications (2003; 2005) The Keys to Success for Mentor and Mentee, Postdoctoral Professionalism Series (2003) Career Pathways and Strategies, Local Traffic Symposium (2003) Career Development Workshop for Emerging Scientists, Science 2004 (2004) Building Your Interpersonal Skills Through Networking, Postdoctoral Professionalism Series (2004) Mock Study Section, Know your K (2005) Writing a Robust Research Proposal, Postdoctoral Professionalism Series (2006) Developing the Networking Skills to Advance Your Career, Postdoctoral Professionalism Series (2007) Being Successful and Striving for Sanity: Balancing Your Career and Your Life, CSML (2007) Mock Study Section, Department of Pediatrics Fellows Course (2007) Revitalizing your Career, American Society of Nephrology Professional Development Seminar (2010) Making Connections: Networking at Professional Meetings and Conferences, Postdoctoral Professionalism Series (2010) Balancing Mentor and Mentee Needs, ICRE Training Early Academic Mentors (TEAM) program (2012) Strategies for Successful Interviewing in Industry and Academe, Postdoctoral Professionalism Series (2012) What You Need to Know to Advance Your Academic Career, Women in Medicine and Science Forum (2012) Career development panel, KL2 Multidisciplinary Advisory Committee (2012) Doctoral Directions career session for the Women in Medicine and Science Association (2013) Mentoring in Different Disciplines, ICRE Training Early Academic Mentors (TEAM) program (2013) Faculty career consultations, Women in Medicine and Science Forum (2014-2018) Mentoring Matters workshop facilitator, ICRE (2014) IWIN Speed Mentoring event (2014) The NIH Peer Review Process (2014) Mission Impossible? How to Navigate the Academic Job Hunt, Bridgeside Research Forum (2014) Setting Expectations, ICRE Training Early Academic Mentors (TEAM) program (2015) Best Practices for Hiring and Mentoring Postdocs, Health Sciences Faculty Professionalism Development Series (2015) Setting Boundaries with Mentees, ICRE Training Early Academic Mentors (TEAM) program (2016) Curr cu um V tae Ora A. We sz

Finding and Using Mentors, Molecular Genetics and Developmental Biology Research in Progress (2016) Work-Life balance, Vascular Medicine Institute postdoctoral round table discussion (2017) Minority Women Professionals are MVPs, “Advocacy for Women” panel moderator (10/2017) Assembling a Mentoring Team for Clinical and Research Faculty in Pathology (11/2018) Women in STEM Faculty Q and A Series, Women in Science and Engineering Graduate Student Organization (1/24/19) Creating an Inclusive Environment, Magee Women’s Research Institute retreat (11/22/2019) Conversations in Academic Science: Do’s and Don’ts, University of Miami CTSI (9/1/2020)

Sessions and series organized Women in Science: Myths and Realities (2001) How to Choose a Postdoc, Local Traffic Symposium (2004) Maximizing Mentoring Relationships, Clinical Research Training Program workshop (2004; 2005) Women Physician-Scientist Seminar series (2004-2006) Sunrise Series (2004-2007) NIH Research Funding and Directions: The Next 10 Years, Local Traffic Symposium (2006) Women in Medicine: Discovering Your Path to Leadership program for medical students (2007) Department of Medicine retreat for senior women faculty (2008) Promotion in the Non-Tenure Stream, Department of Medicine (2008) Promotion in the Tenure Stream, Department of Medicine (2008) Career Success for Faculty Investigators in the Department of Medicine, DOM Faculty Retreat (2010) Effective Interviewing Strategies to Secure Your Dream Job, Doctoral Directions: Learning to Lead in Biomedicine (2015) SPRINGBOARD orientation series for new faculty investigators in the Health Sciences (2015-) Career Mentoring Program (CaMP; director, 2015-2021; organizing committee 2012-2014)

Career development committees Department of Medicine Task Force on Women's and Family Issues (2002-2005) Course in Scientific Management and Leadership (2005-2013) Director, Department of Medicine Junior Faculty Scholar Awards (2007-2016) Director, Department of Medicine Junior Faculty Mentoring Program (2008-2015) UPMC Physician Services Division Physician Inclusion Council (2008-2015) Women in Medicine & Science Forum Steering Committee (2010-present) Co-chair, Mentoring and Retention Subcommittee, Physician Inclusion Council (2011-2018) Internal Medicine Residency Diversity Committee (2011-2018) Organizing committee, UPMC/Pitt Toast to Diversity (2014-) Department of Medicine PhD Faculty Taskforce (2015-) Pitt Faculty Development Marketplace (2016) Planning Committee, Leadership Academy for Early Career Faculty (2016, 2018, 2020) Planning Committee, Advanced Leadership Academy (2017, 2019) Director, Dean’s Faculty Advancement Awards (2016-)

Career development-related presentations University of Pittsburgh Postdoctoral Association General Assembly (2004) Graduate School of Public Health Orientation for New Faculty (2004, 2005)

National committee service Panelist, National Research Council Public Hearing on National Needs for Biomedical and Behavioral Research Personnel, Washington, D.C. (1993) Participant, National Research Council Convocation on Misconduct in Science, Washington, D.C. (1994) Panelist, Career Opportunities for Biomedical Scientists, Johns Hopkins School of Medicine (1996) Abstract Programming Committee, American Society for Cell Biology (1997) Abstract Review Committee, American Society of Nephrology Annual Meeting (2002, 2004, 2016) Member-at-large, Joint Program Committee, American Physiological Society (2005-2007) Abstract Review Chair, Protein Sorting/Epithelial Polarity, Amer. Soc. of Nephrol. Annual Meeting (2006) Program Committee, American Society of Nephrology Annual Meeting (2007-2008) Women in Cell Biology Committee, American Society for Cell Biology (2011-2016); Associate member Curr cu um V tae Ora A. We sz

(2017-) Table Leader, Career Discussion and Mentoring Roundtables, ASCB meeting (2011, 2013-14, 2017-18) CV Reviews, American Society for Cell Biology meeting (2014) Chapter Working Group, NIH NIDDK National Kidney Disease Blueprint (Normal Kidney Biology and Physiology/Development chapter; 2011) American Society of Nephrology PhD Summit, Washington DC, (2013) Applicant reviewer, ELAM program (2016, 2019) Chair, American Society for Cell Biology 2016 Kaluza Prize for Excellence in Graduate Research review committee (2016) Program Committee, ASCB/EMBO 2017 annual meeting (2016) Posters and Professors session, American Physiological Society annual meeting (2018, 2019) American Society for Cell Biology Annual Meeting task force (2018) Publications Committee, American Physiological Society (1/2020-4/2023) Advisory Committee, NIH MOSAIC (Maximizing Opportunities for Scientific and Academic Independent Careers) award to ASCB (2020-) American Society for Cell Biology Honorific Awards task force (2020-2021)

Community activities Organizing committee, National Kidney Foundation Kidney Ball (2005) Science parents committee, The Ellis School (2006-2007)

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