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Implementation Plan Africa Centers of Excellence Project Implementation Plan ACE II MUST 44 2016– 2022 th 08 September 2016 1 | Page Pharm-Bio Technology and Traditional Medicine Centre (PHARMBIOTRAC) [ACE II MUST 44] Implementation Plan 2016– 2022 (Version 08/09/2016) Contact: Casim Umba Tolo (Ph. D) Centre Leader PHARMBIOTRAC Mbarara University of Science & Technology, P. O. Box 1410, Mbarara, Uganda. Tel. No: +256 485 20851, Fax. No: +256 485 20782 Mobile: +256 772 837055 E-mail: [email protected] Website: http://www.must.ac.ug 2 | Page Contents Contents .................................................................................................................................... 3 Abbreviations ............................................................................................................................ 4 1. Brief Narrative Summary ................................................................................................... 6 2. Overview of Planned Outputs, Activity Cost for First Year ........................................... 10 3. Timing of Planned Activities for Entire Project Period ................................................. 22 4. Implementation Arrangements ....................................................................................... 26 4.1 Guiding rules and regulations ..................................................................................... 26 4.2 Governance structures ............................................................................................... 26 4.3 Organizational Chart ................................................................................................... 30 4.4 Project team Roles and responsibilities ...................................................................... 30 4.5 Incentive structures..................................................................................................... 31 4.6 Environment safeguards ............................................................................................. 35 5. Performance Monitoring ................................................................................................. 36 6. Budget .............................................................................................................................. 40 6.1 Summary Budget allocation ........................................................................................ 40 6.2 Detailed Budget .......................................................................................................... 40 7. Detailed Activity Sheets .................................................................................................. 43 8. Annexes ........................................................................................................................... 67 8.1a Procurement Manual ..................................................................................................... 67 8.1b Procurement Plan .......................................................................................................... 67 8.1c Financial Management Plan .......................................................................................... 74 3 | Page Abbreviations ACE African Centre of Excellence AICAD African Institute for Capacity Development BSU Bishop Stuart University BUMETHA Bushenyi Medical & Traditional Healers Association CEMAS Computerized Education. Management and Accounting System CEO Chief Executive Officer Cipla-QCL CIPLA Quality Chemical Industries Limited Uganda DLI Disbursement Linked Indicators DLR Disbursement Linked Results EC Executive Committee EHC Excel Hort Consult Ltd. F&A C Finance and Administration Committee FREC Faculty Research and Ethics Committee GMP Good Manufacturing Practice GU Gulu University HOD Head of Department ICT Information and communications technology IHST Institute of Transdisciplinary Health Sciences and Technology at Transdisciplinary University IRB Institutional Review Board IUCEA Inter-University Council for East Africa KEMRI-CTMDR Kenya Medical Research Institute, Center for Traditional Medicine and Drug Research KHP Kazire Health Products Ltd. LT Lecture Theatre M&E Monitoring and Evaluation Mak-CoNAS Makerere University College of Natural Science MSc Master of Science MoU A memorandum of understanding MUST Mbarara University of Science and Technology MSF Médecins Sans Frontières NCRI Natural Chemotherapeutics Research Institute NDA National Drug Authority NEMA National Environment Management Authority PHARMBIOTRAC Pharm-Bio Technology and Traditional Medicine Centre PhD Doctor of Philosophy PI Principal Investigator Q1, Q2, Q3, Q4, Quarter 1, Quarter 2, Quarter 3, Quarter 4, QAC Quality Assurance Committee REC Research Ethics Committee RUFORUM Regional Universities Forum for Capacity Building in Agriculture SC Steering Committee SDR Special Drawing Rights TBD To Be Determined THETA Traditional and Modern Health Practitioners Together Against AIDS TM Traditional Medicine TMK Traditional Medicine Knowledge TMP Traditional Medical Practice TOR Terms of Reference UCM Catholic University of Mozambique (Universidade Católica de Moçambique) 4 | Page UKZN University of KwaZulu-Natal UNCHE Uganda National Council for Higher Education UNCST Uganda National Council for Science & Technology UOFG University of Gezira USA United States of America USD United States Dollar UTAMU Uganda Technology and Management University WB World Bank WPI Worchester Polytechnic Institute Y1, Y2,Y3, Y4, Y5 Year 1, Year 2, Year 3, Year 4, Year 5 5 | Page 1. Brief Narrative Summary Motivation: Africa has a rich biodiversity that forms the continent’s natural wealth on which its social, cultural and economic systems are largely based, yet Africa still has a low life expectancy and economic productivity compared to other continents. This is majorly due to a high burden of infectious diseases such as malaria, HIV, tuberculosis etc. and now also rising cases of non-communicable diseases, hence causing a dual health challenge. The non-communicable diseases such as cancers, diabetes, hypertension, stroke, obesity, and chronic respiratory disease are becoming the most killer diseases and are predicted to overtake infectious diseases in the near future. This situation is made worse by inadequate yet expensive drugs and even where drugs are available, counterfeit drugs continue to flood the market with up to 35% of antimalarial drugs accessed by the population reported as being fake. For ages, Traditional medicine (TM) and Traditional Medicine Knowledge (TMK) systems have formed part of Africa’s wealth, but has not been science driven to improve quality of life and productivity in the region. Apart from TM and TMK, Africa’s biodiversity has enormous potential to produce modern drugs such as high value biopharmaceuticals but it has not been scientifically explored widely and developed. In addition, very little work has been done in clinical validation of TM and TMK. The lack of clinical evidence creates a huge knowledge gap that limits use by biomedical health practitioners. This in turn limits potential investment in TM related drug discovery and products development by the private industry. While several other factors may be contributing to under-exploitation of TM, and TMK systems and low application of pharm- biotechnology in Africa, the key factors remain; inadequate number of scientists specialized in TM and pharm-biotechnology, lack of multi-disciplinary and trans-disciplinary research teams, lack of appropriate equipment and skills, lack of specialized training in the region to raise the critical mass of scientists in TM and pharm-biotechnology, poor linkages with private sector and non- involvement of TMK holders in the training and research programs. To address these development challenges, Mbarara University of Science and Technology (MUST) through the World Bank’s African Centers of Excellence (ACE) initiative is creating, in the region, a unique framework to produce specialized and highly skilled graduates that will exploit the rich flora and fauna to develop high value science driven TM products and biopharmaceuticals to address not only development challenges of Africa but also preserving the local biodiversity. The ACE will create a conducive and enabling environment for curriculum review and development to create specialization on science driven TM and pharm-biotechnology training, research and product development at postgraduate level. Equipped with state-of-the-art equipment, Pharm-Bio Technology and Traditional Medicine Centre (PHARMBIOTRAC) will be the region’s center of excellence in science driven TM and Pharm-biotechnology. The centre will specialize in systematic identification, documentation, mapping, conservation, harvesting, extraction, isolation, characterization, structural elucidation and modification of active molecules from plants and other life forms for production of high value science driven TM and biopharmaceutical products for uptake by pharmaceutical and herbal medicines industries in the region. Objectives: The main objective of PHARMBIOTRAC is to build a critical mass of specialized and skilled human resource that can advance traditional medicine and Pharm-Biotechnology for socio-economic development of Africa, and the specific objectives include to; Strengthen capacity in the region to train highly skilled and specialized professionals in traditional medicine and Bio-pharmaceuticals, Strengthen capacity in the region to engage in cutting edge research in
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