Africa Centers of Excellence Project

Implementation Plan

ACE II MUST 44

2016– 2022

th 08 September 2016

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Pharm-Bio Technology and Traditional Medicine Centre (PHARMBIOTRAC)

[ACE II MUST 44]

Implementation Plan

2016– 2022

(Version 08/09/2016)

Contact: Casim Umba Tolo (Ph. D) Centre Leader PHARMBIOTRAC of Science & Technology, P. O. Box 1410, Mbarara, . Tel. No: +256 485 20851, Fax. No: +256 485 20782 Mobile: +256 772 837055 E-mail: [email protected] Website: http://www.must.ac.ug

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Contents Contents ...... 3 Abbreviations ...... 4 1. Brief Narrative Summary ...... 6 2. Overview of Planned Outputs, Activity Cost for First Year ...... 10 3. Timing of Planned Activities for Entire Project Period ...... 22 4. Implementation Arrangements ...... 26 4.1 Guiding rules and regulations ...... 26 4.2 Governance structures ...... 26 4.3 Organizational Chart ...... 30 4.4 Project team Roles and responsibilities ...... 30 4.5 Incentive structures...... 31 4.6 Environment safeguards ...... 35 5. Performance Monitoring ...... 36 6. Budget ...... 40 6.1 Summary Budget allocation ...... 40 6.2 Detailed Budget ...... 40 7. Detailed Activity Sheets ...... 43 8. Annexes ...... 67 8.1a Procurement Manual ...... 67 8.1b Procurement Plan ...... 67 8.1c Financial Management Plan ...... 74

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Abbreviations ACE African Centre of Excellence AICAD African Institute for Capacity Development BSU BUMETHA Bushenyi Medical & Traditional Healers Association CEMAS Computerized Education. Management and Accounting System CEO Chief Executive Officer Cipla-QCL CIPLA Quality Chemical Industries Limited Uganda DLI Disbursement Linked Indicators DLR Disbursement Linked Results EC Executive Committee EHC Excel Hort Consult Ltd. F&A C Finance and Administration Committee FREC Faculty Research and Ethics Committee GMP Good Manufacturing Practice GU University HOD Head of Department ICT Information and communications technology IHST Institute of Transdisciplinary Health Sciences and Technology at Transdisciplinary University IRB Institutional Review Board IUCEA Inter-University Council for East Africa KEMRI-CTMDR Kenya Medical Research Institute, Center for Traditional Medicine and Drug Research KHP Kazire Health Products Ltd. LT Lecture Theatre M&E Monitoring and Evaluation Mak-CoNAS College of Natural Science MSc Master of Science MoU A memorandum of understanding MUST Mbarara University of Science and Technology MSF Médecins Sans Frontières NCRI Natural Chemotherapeutics Research Institute NDA National Drug Authority NEMA National Environment Management Authority PHARMBIOTRAC Pharm-Bio Technology and Traditional Medicine Centre PhD Doctor of Philosophy PI Principal Investigator Q1, Q2, Q3, Q4, Quarter 1, Quarter 2, Quarter 3, Quarter 4, QAC Quality Assurance Committee REC Research Ethics Committee RUFORUM Regional Universities Forum for Capacity Building in Agriculture SC Steering Committee SDR Special Drawing Rights TBD To Be Determined THETA Traditional and Modern Health Practitioners Together Against AIDS TM Traditional Medicine TMK Traditional Medicine Knowledge TMP Traditional Medical Practice TOR Terms of Reference UCM Catholic University of Mozambique (Universidade Católica de Moçambique)

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UKZN University of KwaZulu-Natal UNCHE Uganda National Council for Higher Education UNCST Uganda National Council for Science & Technology UOFG University of Gezira USA United States of America USD United States Dollar UTAMU Uganda Technology and Management University WB World Bank WPI Worchester Polytechnic Institute Y1, Y2,Y3, Y4, Y5 Year 1, Year 2, Year 3, Year 4, Year 5

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1. Brief Narrative Summary Motivation: Africa has a rich biodiversity that forms the continent’s natural wealth on which its social, cultural and economic systems are largely based, yet Africa still has a low life expectancy and economic productivity compared to other continents. This is majorly due to a high burden of infectious diseases such as malaria, HIV, tuberculosis etc. and now also rising cases of non-communicable diseases, hence causing a dual health challenge. The non-communicable diseases such as cancers, diabetes, hypertension, stroke, obesity, and chronic respiratory disease are becoming the most killer diseases and are predicted to overtake infectious diseases in the near future. This situation is made worse by inadequate yet expensive drugs and even where drugs are available, counterfeit drugs continue to flood the market with up to 35% of antimalarial drugs accessed by the population reported as being fake. For ages, Traditional medicine (TM) and Traditional Medicine Knowledge (TMK) systems have formed part of Africa’s wealth, but has not been science driven to improve quality of life and productivity in the region. Apart from TM and TMK, Africa’s biodiversity has enormous potential to produce modern drugs such as high value biopharmaceuticals but it has not been scientifically explored widely and developed. In addition, very little work has been done in clinical validation of TM and TMK. The lack of clinical evidence creates a huge knowledge gap that limits use by biomedical health practitioners. This in turn limits potential investment in TM related drug discovery and products development by the private industry. While several other factors may be contributing to under-exploitation of TM, and TMK systems and low application of pharm- biotechnology in Africa, the key factors remain; inadequate number of scientists specialized in TM and pharm-biotechnology, lack of multi-disciplinary and trans-disciplinary research teams, lack of appropriate equipment and skills, lack of specialized training in the region to raise the critical mass of scientists in TM and pharm-biotechnology, poor linkages with private sector and non- involvement of TMK holders in the training and research programs. To address these development challenges, Mbarara University of Science and Technology (MUST) through the World Bank’s African Centers of Excellence (ACE) initiative is creating, in the region, a unique framework to produce specialized and highly skilled graduates that will exploit the rich flora and fauna to develop high value science driven TM products and biopharmaceuticals to address not only development challenges of Africa but also preserving the local biodiversity. The ACE will create a conducive and enabling environment for curriculum review and development to create specialization on science driven TM and pharm-biotechnology training, research and product development at postgraduate level. Equipped with state-of-the-art equipment, Pharm-Bio Technology and Traditional Medicine Centre (PHARMBIOTRAC) will be the region’s center of excellence in science driven TM and Pharm-biotechnology. The centre will specialize in systematic identification, documentation, mapping, conservation, harvesting, extraction, isolation, characterization, structural elucidation and modification of active molecules from plants and other life forms for production of high value science driven TM and biopharmaceutical products for uptake by pharmaceutical and herbal medicines industries in the region. Objectives: The main objective of PHARMBIOTRAC is to build a critical mass of specialized and skilled human resource that can advance traditional medicine and Pharm-Biotechnology for socio-economic development of Africa, and the specific objectives include to;  Strengthen capacity in the region to train highly skilled and specialized professionals in traditional medicine and Bio-pharmaceuticals,  Strengthen capacity in the region to engage in cutting edge research in TM and systems biology for health products development,  Create capacity in collaboration with private sector industry for development, production and commercialization of TM, biopharmaceuticals and nutraceuticals from research outputs,

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 Advance the practices of TM/TMK in the region and promote domestication and sustainable utilization of medicinal species.

Methodology: MUST is mandated to teach both undergraduate and graduate programmes (MSc & PhD), as well as short courses and it promotes transfer of scientific knowledge and innovations to the community for sustainable society transformation. PHARMBIOTRAC will attract multidisciplinary students from the region including botanists, biochemists, chemists, pharmacognocists, engineers, pharmacologists, pharmacists, microbiologists, biotechnologists, and train them through transdisciplinary approaches to build teams for joint projects and enterprises. PHARMBIOTRAC will use scientific methods to improve TM products and to identify active molecules that can be developed into biopharmaceuticals. To achieve its goal, PHARMBIOTRAC will augment its existing teaching faculty by attracting and recruiting specialist hands-on scientists from the region and mentor them in collaboration with professors from partner universities in USA, India and South Africa. The centre, through the transdisciplinary approach of graduate training and specialization will lead to teamwork in the development of science-driven TM products and biopharmaceuticals, leading to their commercial production in the region by private sector industries. Through dynamical linking of research and education to industry, the research outputs and the graduates will be absorbed by private sector industry to mass produce high value science driven TM products and biopharmaceuticals highly needed for disease control and prevention worldwide. The application of Pharm-biotechnology particularly systems biology will spur drug discovery leading to production of biopharmaceuticals for national, regional and international markets. In addition to biopharmaceutical industry, the graduates of PHARMBIOTRAC will serve as faculties in partner universities, and other organizations in the region to train more specialists in TM and biopharmaceuticals.

Results: Some of the envisioned outputs of PHARMBIOTRAC within 5 years will include;  30PhD graduated at the end of 5 years specialised in TM, drug production and drug discovery,  60 MSc graduated at the end of 5 years with career path in TM, drug production and value chain management,  At least 2 programs internationally and regionally accredited by an international quality assurance agency at the end of 5 years,  150 peer reviewed publication in international reputed journals at the end of 5 years,  8 drug molecule patents registered,  2 Research projects jointly launched with private sector and or partner universities,  2 products licensed for commercial production by national or regional private sector industry,  2 product monographs,  5000 Traditional Medical Practitioners (TMPs) fully trained through short courses (5 modules),  100 Herbal medicine producers trained in tailor-made short courses on quality, safety and efficacy of their products in line Good Manufacturing Practices (GMP),  At least 5 conferences organised at the end of 5 years,  275 conference presentations by students and faculty (at national, regional and international level),  Regional students, faculty and governments highly attracted to the centre and its services.

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Partnerships: A total of 18 partners were finally carefully selected to tap into their vast experience and expertise in various fields of Pharm-Biotechnology and Traditional medicine and who expressed interest through provision of support letters for PHARMBIOTRAC. The collaboration is anticipated in various ways including; • Visiting lectureship, Student placements, external examiner secondment, external supervision, etc. • Joint research and publication, whereby more research grants are sourced through proposal writing and networking. In this case, it is of great advantage to have a diverse pool of partners from where consortia can be constituted for joint future engagement, outreach and sustainability. However, one national partner - Uganda Industrial Research Institute (UIRI) has been dropped because MUST already has collaboration with them and the same arrangement will be used for PHARMBIOTRAC. In addition, one Regional Partner - Institute of Traditional Medicine Muhimbili University of Health and Allied Sciences (ITMUHASU), Tanzania, has been dropped from the list of partners due to absence of a support letter from them. Nevertheless, ITMUHASU will still be notified of the opportunities for their staff to train at PHARMBIOTRAC when the program starts. Table 1: PHARMBIOTRAC partners national, regional and international include; No Abbreviation Full Name 1 BSU Bishop Stuart University 2 GU Gulu University 3 Mak-CoNAS Makerere University College of Natural Science 4 UTAMU Uganda Technology and Management University 5 UKZN – South Africa University of KwaZulu-Natal 6 UOFG – Sudan University of Gezira 7 UCM – Mozambique Catholic University of Mozambique 8 WPI – USA Worchester Polytechnic Institute Massachusetts 9 IHST – India Institute of Transdisciplinary Health Sciences and Technology at Transdisciplinary University 10 KEMRI-CTMDR – Kenya Medical Research Institute, Center for Traditional Medicine Kenya and Drug Research 11 NCRI Natural Chemotherapeutics Research Institute 12 Cipla-QCL CIPLA Quality Chemical Industries Limited Uganda 13 EHC Excel Hort Consult Ltd. 14 KHP Kazire Health Products Ltd. 15 BUMETHA Bushenyi Medical & Traditional Healers Association 16 UNCST Uganda National Council for Science and Technology 17 RUFORUM Regional Universities Forum For Capacity Building in Agriculture 18 AICAD African Institute for Capacity Development

Important changes made in the proposal: The important changes made following PHARMBIOTRAC proposal review are; 1. The Financial Management and Administration Structure: - In addition to the Project’s Director Finance and Administration, there shall be two Project Accountants for PHARMBIOTRAC; one is already university employee in finance department and the other will be recruited and paid directly by the project. They shall report to the Director Finance and Administration who is the deputy university bursar who in turn will report to the University Secretary (Accounting officer, MUST) and the center leader. 2. Financial transactions: - Shall be maintained by Quick books software. Authorization and approval of project transactions shall follow the University‘s established structures.

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However, the center leader shall be the principal approver of all transactions and the principal signatory to the PHARMBIOTRAC bank account that will be operated at Standard Chartered Bank with either the director finance and administration or the University Secretary as co-signatories. 3. Acronym change: - ‘PHARMTRAC’ has been changed to PHARMBIOTRAC. 4. Support by government: - will include; payment of the wage bill of more than 80% of PHARMBIOTRAC faculty and support staff in addition to provision of space and laboratories for learning and research. The Natural Chemotherapeutics Research Institute of the Ministry of Health is financed by government of Uganda to conduct research in Traditional Medicine is a key partner of PHARMBIOTRAC and will offer its facilities and staff for training of PHARMBIOTRAC students. 5. ‘Ethical and institutional review board’ set-up and practices: - MUST has a very strong IRB empowered by the National IRB to vet and register all research activities in the western region of Uganda. The chair Research of PHARMBIOTRAC, Prof Juliet Mwanga and her team will ensure that all research projects and activities are approved by the Faculty Research and Ethics Committee (FREC) of medicine faculty, Institutional Review Board/Research Ethics Committee (REC) of the university and also registration with the Uganda National Council for Science and Technology (UNCST) and other regional bodies as may be necessary. 6. Involvement of Ethnobotanists and Pathologists: - MUST has a strong department of pathology under the Faculty of Medicine and this department has been included as a core unit to take care of drug toxicity studies and training of students. MUST Faculty of Science also has very experienced and highly trained Ethnobotanist, Dr. Eunice Olet in the Faculty of Science. She will work with Prof. Maud Kamatanesi (Ethnobotanist) of Bishop Stuart University and Prof. Hannington Oryem-Origa (Ethnobotanist/plant biologist) of Makerere University to train and mentor students and conduct research in ethnobotany aspects of PHARMBIOTRAC. 7. Augmentation of modern drug discovery subject areas: in addition to focus on TM and drug production systems, an MSc program on modern drug discovery utilising systems biology and biotechnology has been revised to create PhD tracks for modern drug discovery and development. 8. Reduction of number of local partners: the number of local partners has been reduced from 10 to 9 concentrating on those who gave letters of support and those who add strength to the project.

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2. Overview of Planned Outputs, Activity Cost for First Year Table 2: Overview of first project year Code Priority Result/Activity/Task Budget Estimate (US$) Rank ACE Partners Total leader Action (1 highest 5.1 Action Plan for archiving Learning (Component (Componen (Total of Plan1 5 lowest) Excellence total for t total for component) ACE leader) partners) 5.1.1 1 Benchmarking visits (India) 35,360 - 35,360 5.1.2 1 Benchmarking visits (South Africa) 29,290 - 29,290 5.1.3 1 Benchmarking visits (USA) 37,995 - 37,995 5.1.4 3 Establishment of learning teams 1,000 - 1,000 5.1.5 2 Installation of ICT systems for learning 10,000 - 10,000 5.1.6 1 Curriculum development (Short courses MSc & PHD ) 20,400 - 20,400 5.1.7 1 Curriculum accreditation (Fast Track fees) 16,000 - 16,000 5.1.8 3 Student Handbooks (PhD & Masters) 340 - 340 5.1.9 2 Learning materials (lecturers reference materials, 6,000 - 6,000 demonstration materials etc.) 5.1.10 3 Upgrading Learning Facilities Pharmacy (production unit) 70,000 - 70,000 5.1.11 3 Lecture room upgrade 12,000 - 12,000 5.1.12 3 Digital Library / ICT learning centre / video conferencing 50,000 - 50,000 facilities/ computer workstations for students 5.1.13 4 Standby generator (purchase & installation) 10,000 - 10,000 5.1.14 4 Fuel and maintenance 3,600 - 3,600 5.1.15 1 Chair Learning Excellence coordination 660 - 660 5.1.16 3 Advertisement/ assembling of trainers/ recruitment of 2,000 500 2,500 students for short courses and training 5.1.17 3 Advertisement/ assembling, recruitment of students for 2,000 500 2,500 MSc and PhD, and training 5.1.18 2 Facilitation for industry experts / practitioners (10 ppl) - 4,500 4,500 5.1.19 1 Tuition Fee PhD 30,000 - 30,000 5.1.20 1 Tuition Fee MSc 24,000 - 24,000 5.1.21 1 Traditional Medicine Clinics setup and maintenance 20,000 - 20,000 5.1.22 1 Stipend PhD (annually) 45,000 - 45,000 5.1.23 1 Stipend MSc (annually) 30,000 - 30,000 5.1.24 1 Travel (Flights) for Students (return flights) 4,800 - 4,800 5.1.25 2 External examiners 1,500 - 1,500 5.1.26 3 Annual dissemination conference and Annual general - - - meeting 5.1.27 1 Student presentation at national conferences 2,500 - 2,500 5.1.28 1 Student presentation at regional conferences - - - 5.1.29 1 Student presentation at international conferences - - - 5.1.30 1 Community / Industry attachments (Masters) 6,900 - 6,900 5.1.31 2 Community / Industry attachments (PhD) 6,800 - 6,800 5.1.32 2 30 Seater Bus 50,000 - 50,000 5.1.33 1 Bus (fuel and maintenance) 7,200 - 7,200 5.1.34 5 Medical emergency fund / First Aid kit 1,000 - 1,000 5.1 Subtotal 536,345 5,500 541,845

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Code Priority Result/Activity/Task Budget Estimate (US$) Rank ACE Partners Total leader Action (1 highest 5.2 Action Plan for archiving Research Excellence (Component (Componen (Total of Plan 2 5 lowest) total for t total for component) ACE leader) partners) 5.2.1 3 Research Policy and Plan draft development (Y1 4,620 - 4,620 development Y4 review) 5.2.2 3 Research Policy and Plan finalisation (Y1 development Y4 15,900 1,750 17,650 review) 5.2.3 1 Staff attachments to foreign laboratories WPI (USA) - 7,775 7,775 5.2.4 1 Staff attachments to foreign laboratories IHST (India) - 5,550 5,550 5.2.5 1 Staff attachments to foreign laboratories KEMRI (Kenya) - 15,600 15,600 5.2.6 1 Staff attachments to foreign laboratories Gezira (Sudan) - 16,050 16,050 5.2.7 1 Establishment of Living gene bank (Garden) - MUST 26,000 - 26,000 5.2.8 1 Staff research funds 15,000 - 15,000 5.2.9 2 Staff participation in regional conference 14,550 - 14,550 5.2.10 2 Staff participation in international conference 17,600 - 17,600 5.2.11 1 Germplasm collection missions (MUST) 11,000 - 11,000 5.2.12 1 Pharm-Biotech laboratory equipment purchase, 94,500 - 94,500 installation, tear and wear 5.2.13 1 Product development laboratory, purchase, installation, 188,600 - 188,600 tear and wear 5.2.14 1 Analytical Laboratory, purchase, installation, tear and wear 118,500 - 118,500 5.2.15 2 Journal Publication fee (Open Access) 12,500 - 12,500 5.2.16 3 Patenting Fees - - - 5.2.17 2 Monographs (Product Monographs) 6,000 - 6,000 5.2.18 1 Masters Seminars 1,860 - 1,860 5.2.19 1 Doctoral Seminars 1,860 - 1,860 5.2.20 1 Supervision fee (Masters) - - - 5.2.21 1 Supervision fee (PhD) - - - 5.2.22 1 Supervision fee field (Masters) (3 days / semester) 3,000 - 3,000 5.2.23 1 Supervision fee fee (PhD) (3 days/ semester) 2,000 - 2,000 5.2.24 4 Joint follow up proposal development - - - 5.2.25 2 Chair Research Excellence coordination 660 - 660 5.2.26 1 Research support for MSc students 21,000 - 21,000 5.2.27 1 Research support for PhD students 45,000 - 45,000 5.2.28 1 Station wagon purchase (4 wheel drive) 100,000 - 100,000 5.2.29 1 Fuel and maintenance for Station wagon (4 wheel drive) 16,800 - 16,800 5.2.30 1 Laboratory technician 6,000 - 6,000 5.2 Subtotal 722,950 46,725 769,675 Action (1 highest 5.3 ACE Action Plan for archiving Quality Assurance (Component (Componen (Total of Plan 3 5 lowest) total for t total for component) ACE leader) partners) 5.3.1 2 Quality Assurance and M&E consultancy 4,000 - 4,000 5.3.2 1 Chair Learning and Research Quality Assurance 660 - 660 5.3.3 3 Tracer studies 3,000 - 3,000 5.3 Subtotal 7,660 - 7,660 Action (1 highest 5.4 ACE Action Plan regarding Equity Dimensions (Component (Componen (Total of Plan 4 5 lowest) total for t total for component) ACE leader) partners) 5.4.1 1 Access audit 2,000 - 2,000 5.4.2 2 Facility upgrade 4,000 - 4,000 5.4 Subtotal 6,000 - 6,000 Action (1 highest 5.5 ACE Action Plan for Attracting Academic Staff and (Component (Componen (Total of Plan 5 5 lowest) Students from the Region (Expected output) total for t total for component) ACE leader) partners)

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Code Priority Result/Activity/Task Budget Estimate (US$) Rank ACE Partners Total leader 5.5.1 2 Dissemination of Research Policy to attract academic staff 1,000 - 1,000 of the region 5.5.2 1 Language learning support 3,000 - 3,000 5.5.3 1 Recruited staff salaries (2 senior lecturers) 48,000 - 48,000 5.5 Subtotal 52,000 - 52,000 Action (1 highest 5.6 ACE Action Plan for National and Regional Academic (Component (Componen (Total of Plan 6 5 lowest) Partners (Expected output) total for t total for component) ACE leader) partners) 5.6.1 1 Regional Visiting faculty members - Kenya - 7,410 7,410 5.6.2 1 Regional Visiting faculty members - South Africa - 7,410 7,410 5.6.3 1 Regional Visiting faculty members - Sudan - 7,410 7,410 5.6.4 1 Regional Visiting faculty members - Mozambique - 7,410 7,410 5.6.5 1 National Visiting faculty members - BSU - 2,960 2,960 5.6.6 1 National Visiting faculty members - Makerere - 3,260 3,260 5.6.7 1 National Visiting faculty members - UTAMU - 3,260 3,260 5.6.8 1 National Visiting faculty members - Gulu University - 3,460 3,460 5.6.9 1 Student attachment African Partner - KEMRI - Kenya - 19,000 19,000 5.6.10 1 Student attachment African Partner - Gezira University - - 21,000 21,000 Sudan 5.6.11 2 Establishment of Living gene bank (Garden) - BSU/GU - 26,000 26,000 5.6.12 2 Germplasm collection maintenance (BSU) - 4,060 4,060 5.6.13 2 Germplasm collection maintenance (Gulu University) - 4,060 4,060 5.6 Subtotal - 116,700 116,700 Action (1 highest 5.7 ACE Action Plan for National and Regional Sector (Component (Componen (Total of Plan 7 5 lowest) Partners (Expected output) total for t total for component) ACE leader) partners) 5.7.1 1 Community training kits 6,300 - 6,300 5.7.2 2 Training Centre (Traditional Medical Practitioners) - 10,000 10,000 BUMETHA 5.7.3 3 Training Centre (Traditional Medical Practitioners) IIACM 10,000 - 10,000 5.7.4 3 Training Centre (Traditional Medical Practitioners) 10,000 - 10,000 THETA-Uganda 5.7.5 2 Training Centre (Traditional Medical Practitioners) 10,000 - 10,000 ANAMED 5.7.6 2 Training Centre (Traditional Medical Practitioners) NCRL 10,000 - 10,000 centre 5.7 Subtotal 46,300 10,000 56,300 Action (1 highest 5.8 ACE Action Plan for Collaboration with International (Component (Componen (Total of Plan 8 5 lowest) Academic Partners total for t total for component) (Expected output) ACE leader) partners) 5.8.1 1 International Visiting faculty members (USA) - 9,090 9,090 5.8.2 1 International Visiting faculty members (India) - 7,490 7,490 5.8.3 1 Sabbatical Place (6 months per year) 21,300 - 21,300 5.8 Subtotal 21,300 16,580 37,880 Action (1 highest 5.9 ACE Action Plan for Management and Governance (Component (Componen (Total of Plan 9 5 lowest) (Expected output) total for t total for component) ACE leader) partners) 5.9.1 1 Establishment of PHARMBIOTRAC secretariat 23,000 - 23,000 5.9.2 2 Installation of ICT systems for finance & administration 5,000 - 5,000 5.9.3 1 Inception and planning meeting of all partners 18,036 17,700 35,736 5.9.4 2 Meeting of Steering Committee 9,060 - 9,060 5.9.5 2 Meeting of Executive Committee 1,140 - 1,140 5.9.6 2 Meeting of Finance & Administration committee 480 - 480 5.9.7 1 Core Team Project review and planning meeting 5,550 - 5,550 5.9.8 1 PHARMBIOTRAC meetings with WB & IUCEA 3,920 - 3,920

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Code Priority Result/Activity/Task Budget Estimate (US$) Rank ACE Partners Total leader 5.9.9 1 Bi-Annual Meeting by IUCEA 24,040 - 24,040 5.9.10 1 Staff orientation workshop 1,000 - 1,000 5.9.11 1 PHARMBIOTRAC Administrator 24,000 - 24,000 5.9.12 1 PHARMBIOTRAC Administrative Assistant 6,000 - 6,000 5.9.13 1 PHARMBIOTRAC Accountant 24,000 - 24,000 5.9.14 2 PHARMBIOTRAC Procurement Assistant 6,000 - 6,000 5.9.15 1 Partner coordination / supervision visits regional (2 ppl) 17,880 - 17,880 5.9.16 1 Driver 3,000 - 3,000 5.9.17 1 Cleaner 2,400 - 2,400 5.9.18 1 Office supplies 1,800 - 1,800 5.9 Subtotal 176,306 17,700 194,006 Action (1 highest 5.10 ACE Action Plan for archiving Sustainable Financing (Component (Componen (Total of Plan 5 lowest) (Expected output) total for t total for component) 10 ACE leader) partners) 5.10.1 1 Chair Innovation & Business Management 30,000 - 30,000 5.10.2 2 Business clinic (furniture, computer, software) 8,800 - 8,800 5.10.3 2 Product exhibitions (Regional) 5,200 - 5,200 5.10.4 2 Product exhibitions (National) 2,280 - 2,280 5.10.5 4 Chair innovation & Business Management Meetings 660 - 660 5.10.6 1 Student handbooks (in-service professionals short course) 1,000 - 1,000 5.10.7 1 Student handbooks (short course for TMPs) 5,000 - 5,000 5.10.8 3 Business clinic coordination & branding 15,600 - 15,600 5.10 Subtotal 68,540 - 68,540 Action (1 highest 5.11 ACE Action Plan for Monitoring and Evaluation (Component (Componen (Total of Plan 5 lowest) (Expected output) total for t total for component) 11 ACE leader) partners) 5.11.1 1 Strategic plan draft development 4,620 - 4,620 5.11.2 2 Strategic plan finalisation 8,500 3,150 11,650 5.11.3 2 M&E Missions (internal) 4,000 - 4,000 5.11 Subtotal 17,120 3,150 20,270 Subtotal (Operation) 1,654,521 216,355 1,870,876

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Table 3: Overview distribution among partners Code Result/Activity/Task Budget Estimate (US$). NB: Coding for partner organisation (see Table 4)

Action

Plan

QCL

-

CoNAS

Budget

-

TotalPartner

BSU GU Mak UTAMU UKZN UOFG UCM WPI IHST KEMRI NCRI Cipla EHC KHP BUMETHA UNCST RUFORUM AICAD

AP 1 5.1 Action Plan for Learning Excellence

5.1.16 Advertisement/ assembling of trainers/

500 500 500

Recruitment of students for short courses and

training

5.1.17 Advertisement/ assembling, recruitment of

500 500 500

students for MSc and PhD, and training

5.1.19 Facilitation for industry experts / practitioners (10

ppl)

1,500 1,500 3,000 4,500

Subtotal

2,500 2,500 3,000 5,500

AP 2 5.2 Action Plan for archiving Research Excellence

------

5.2.2 Research Policy and Plan finalisation (Y1 development Y4 750

review) 750 1,000 1,000

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Code Result/Activity/Task Budget Estimate (US$). NB: Coding for partner organisation (see Table 4)

Action

Plan

QCL

-

CoNAS

Budget

-

TotalPartner

BSU GU Mak UTAMU UKZN UOFG UCM WPI IHST KEMRI NCRI Cipla EHC KHP BUMETHA UNCST RUFORUM AICAD

------

5.2.3 Staff attachments to foreign laboratories (USA)

7,775 7,775

------

5.2.4 Staff attachments to foreign laboratories (India)

5,550 5,550

------

5.2.5 Staff attachments to foreign laboratories (KEMRI)

15,600

------

5.2. Staff attachments to foreign laboratories Gezira

16,050

------

Subtotal

750 750

1,000 1,000 7,775 5,550

16,050 15,600 46,725

AP 6 ACE Action Plan for National and Regional Academic

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Code Result/Activity/Task Budget Estimate (US$). NB: Coding for partner organisation (see Table 4)

Action

Plan

QCL

-

CoNAS

Budget

-

TotalPartner

BSU GU Mak UTAMU UKZN UOFG UCM WPI IHST KEMRI NCRI Cipla EHC KHP BUMETHA UNCST RUFORUM AICAD

------

5.6.1 Regional Visiting faculty members - Kenya

7,410 7,410 7,410

------

5.6.2 Regional Visiting faculty members - South Africa

,410 ,410

7,410 7,410 7

------

5.6.3 Regional Visiting faculty members - Sudan

7,410 7,410 7,410

------

5.6.4 Regional Visiting faculty members - Mozambique

7,410 7,410 7,410

------

5.6.5 National Visiting faculty members - BSU

2,960 2,960 2,960

------

5.6.6 National Visiting faculty members - Makerere

3,260 3,260 3,260

------

5.6.7 National Visiting faculty members - UTAMU

3,260 3,260 3,260

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Code Result/Activity/Task Budget Estimate (US$). NB: Coding for partner organisation (see Table 4)

Action

Plan

QCL

-

CoNAS

Budget

-

TotalPartner

BSU GU Mak UTAMU UKZN UOFG UCM WPI IHST KEMRI NCRI Cipla EHC KHP BUMETHA UNCST RUFORUM AICAD

------

5.6.8 National Visiting faculty members - Gulu University

3,460 3,460 3,460

------

5.6.9 Student attachment African Partner - KEMRI - Kenya

19,000 19,000

------

5.6.10 Student attachment African Partner - Gezira University -

Sudan

21,000 21,000

------

5.6.11 Establishment of Living gene bank (Garden) - BSU/GU

13,000 13,000 26,000

------

5.6.12 Germplasm collection maintenance (BSU)

4,060 4,060 4,060

------

5.6.13 Germplasm collection maintenance (Gulu University)

4,060 4,060 4,060

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Code Result/Activity/Task Budget Estimate (US$). NB: Coding for partner organisation (see Table 4)

Action

Plan

QCL

-

CoNAS

Budget

-

TotalPartner

BSU GU Mak UTAMU UKZN UOFG UCM WPI IHST KEMRI NCRI Cipla EHC KHP BUMETHA UNCST RUFORUM AICAD

------

Subtotal

3,260 3,260 3,260 7,410 7,410

20,020 20,020 20,520 28,410 26,410 116,700 116,700

AP 7 5.7 ACE Action Plan for National and Regional Sector Partners

5.7.2 Training Centre (Traditional Medical Practitioners)

BUMETHA

56300

10,000

Subtotal

89,500 89,500

56300

AP 8 5.8 ACE Action Plan for Collaboration with International Academic Partners

------

5.8.1 International Visiting faculty members (USA)

9,090 9,090 9,090

------

5.8.2 International Visiting faculty members (India)

7,490 7,490 7,490

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Code Result/Activity/Task Budget Estimate (US$). NB: Coding for partner organisation (see Table 4)

Action

Plan

QCL

-

CoNAS

Budget

-

TotalPartner

BSU GU Mak UTAMU UKZN UOFG UCM WPI IHST KEMRI NCRI Cipla EHC KHP BUMETHA UNCST RUFORUM AICAD

------

Subtotal ------

9,090 9,090 7,490 16,580

AP 9 5.9 ACE Action Plan for Management and Governance

5.9.3 Inception and planning meeting of all partners

550 550 700 600 600 600 600 450 450 450 600 600

1,500 1,500 1,450 1,450 3,100 1,500 1,250 1,250

17,700

Subtotal

550 700 600 600 600 600 450 450 450 600 600

1,500 1,500 1,450 1,450 3,100 1,500 1,250 1,250 17,700 17,700

AP 11 5.11 ACE Action Plan for Monitoring & Evaluation

5.11.2 Strategic plan finalisation

450 450 700 500 500 500 500

3,150 3,150

Subtotal

450 700 500 500 500 500 3,150 3,150

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Code Result/Activity/Task Budget Estimate (US$). NB: Coding for partner organisation (see Table 4)

Action

Plan

QCL

-

CoNAS

Budget

-

TotalPartner

BSU GU Mak UTAMU UKZN UOFG UCM WPI IHST KEMRI NCRI Cipla EHC KHP BUMETHA UNCST RUFORUM AICAD

Total per Partner Y1

600 600 450 450 600

4,360 4,360 4,360 8,930 8,880 1,100 3,600 4,250

21,770 21,770 22,920 48,630 21,710 16,910 51,380 10,450

231,350 231,350

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Table 4: Coding of partner organisation No Abbreviation Full Name 1 BSU Bishop Stuart University 2 GU Gulu University 3 Mak-CoNAS Makerere University College of Natural Science 4 UTAMU Uganda Technology and Management University 5 UKZN - South Africa University of KwaZulu-Natal 6 UOFG – Sudan University of Gezira 7 UCM – Mosambique Catholic University of Mozambique 8 WPI – USA Worchester Polytechnic Institute 9 IHST – India Institute of Transdisciplinary Health Sciences and Technology at Transdisciplinary University 10 KEMRI-CTMDR – Kenya Kenya Medical Research Institute, Center for Traditional Medicine and Drug Research 11 NCRI Natural Chemotherapeutics Research Institute 12 Cipla-QCL CIPLA Quality Chemical Industries Limited Uganda 13 EHC Excel Hort Consult Ltd. 14 KHP Kazire Health Products Ltd. 15 BUMETHA Bushenyi Medical & Traditional Healers Association 16 UNCST Uganda National Council for Science & Technology 17 RUFORUM Regional Universities Forum For Capacity Building in Agriculture 18 AICAD African Institute for Capacity Development

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3. Timing of Planned Activities for Entire Project Period

Table 5: Work plan for the project Timeline (Implementation months) Activity 1 2 3 4 5 6 7 8 9 10 11 12 5.1 Action Plan for Learning Excellence Benchmarking visits (India) Benchmarking visits (South Africa) Benchmarking visits (USA) Establishment of learning teams Installation of ICT systems for learning Curriculum development (Short courses MSc &

PHD ) Curriculum accreditation Advertisement of short courses, assembling of trainers Student Handbooks (PhD, Masters & short courses, TMPs) Learning materials (lecturer’s reference materials, demonstration materials etc.) Upgrading Learning Facilities Pharmacy Lecture Lecture rooms Digital Library / ICT learning centre / video conferencing facilities/ computer workstations for students Standby generator (purchase & installation) Fuel and maintenance Facilitation for industry experts / practitioners

(10 ppl) Tuition Fee PhD Tuition Fee MSc Stipend PhD (annually) Stipend MSc (annually) External examiners Annual dissemination conference and Annual general meeting Student presentation at national conferences Travel (Flights for students) Community / Industry attachments (Masters) Community / Industry attachments (PhD) 30 Seater Bus Fuel and maintenance (bus) 5.2 Action Plan for Research Excellence Research Policy and Plan draft development (Y1 development Y4 review)

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Timeline (Implementation months) Activity 1 2 3 4 5 6 7 8 9 10 11 12 Research Policy and Plan finalisation (Y1 development Y4 review) Staff attachments to foreign laboratories (WPI,

USA) Staff attachments to foreign laboratories (ITHST,

India) Staff attachments to regional laboratories

(KEMRI, Kenya) Staff attachments to regional laboratories

(Gezira University, Sudan) Establishment of Living gene bank (Garden) –

MUST Fuel and maintenance of pick up Germplasm collection missions (MUST) Pharm-Biotech Laboratory equipment purchase, installation, tear and wear Product development Laboratory, purchase, installation, tear and wear Analytical Laboratory, purchase, installation, tear and wear Journal Publication fee (Open Access) Monographs (Product Monographs) Masters Seminars Doctoral Seminars Field Supervision fee (Masters) Field Supervision fee (PhD) Supervision field facilitation (Masters) (6 days / semester) Supervision field facilitation (PhD) (6 days/ semester) Chair Research Excellence coordination Research support for MSc students Research support for PhD students Station wagon (4x4) procurement Fuel and maintenance of Station wagon Laboratory Technician 5.3 Action Plan for Quality Assurance Identification and selection of M&E consultant Quality Assurance and M&E (Consultant) engaged Schedule and hold internal M&E meetings with consultant Chair Learning and Research Quality Assurance (Develop internal M&E plan and data collection tools) tracer studies 5.4 ACE Action Plan regarding Equity Dimensions

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Timeline (Implementation months) Activity 1 2 3 4 5 6 7 8 9 10 11 12 Access audit Facility upgrade 5.5 ACE Action Plan for Attracting Academic Staff and Students from the Region Dissemination of Research Policy to attract academic staff of the region Advertising and wide dissemination of calls for

PhD and Masters courses Language learning support Recruited staff salaries (2 senior lecturers) 5.6 ACE Action Plan for National and Regional Academic Partners Regional Visiting faculty members - Kenya Regional Visiting faculty members - South Africa Regional Visiting faculty members - Sudan Regional Visiting faculty members –

Mozambique National Visiting faculty members - BSU National Visiting faculty members - Makerere National Visiting faculty members - UTAMU National Visiting faculty members - Gulu

University Student attachment African Partner - KEMRI –

Kenya Student attachment African Partner - Gezira

University - Sudan Establishment of Living gene bank (Garden) -

BSU/GU Germplasm collection maintenance (BSU) Germplasm collection maintenance (Gulu

University) 5.7 ACE Action Plan for National and Regional Sector Partners Community training kits Training Centre (Traditional Medical

Practitioners) BUMETHA Training Centre (Traditional Medical

Practitioners) IIACM Training Centre (Traditional Medical

Practitioners) THETA-Uganda Training Centre (Traditional Medical

Practitioners) ANAMED Training Centre (Traditional Medical

Practitioners) NCRL centre 5.8 ACE Action Plan for Collaboration with International Academic Partners International Visiting faculty members (USA)

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Timeline (Implementation months) Activity 1 2 3 4 5 6 7 8 9 10 11 12 International Visiting faculty members (India) Sabbatical Place (6 months per year) Negotiate and sign funding contract 5.9 ACE Action Plan for Management and Governance Establishment of PHARMBIOTRAC secretariat Put in place governance framework, financial management, administrative, procurement, monitoring and evaluation procedures and systems Installation of ICT systems for finance & administration Inception and planning meeting of all partners Meeting of Steering Committee Meeting of Executive Committee Meeting of Finance & Administration committee Staff orientation workshop PHARMBIOTRAC Administrator (recruitment) PHARMBIOTRAC Administrative Assistant

(recruitment) Chair, Finance and Administration (in place) PHARMBIOTRAC Accountant (in place) PHARMBIOTRAC Accounts Assistant

(recruitment) PHARMBIOTRAC Internal Auditor (in place) Centre Leader (in place) Deputy Centre Leader / PI (in place) Partner coordination visits regional (2 ppl) Driver recruitment and salary Cleaner recruitment and salary 5.10 ACE Action Plan for Sustainable Financing Chair Innovation & Business Management salary Business clinic (furniture, computer, software) Product Exhibitions (Regional) Product Exhibitions (National) Business clinic coordination & branding 5.11 ACE Action Plan for Monitoring and Evaluation Strategic plan draft development Strategic plan finalisation Collect, collate, analyse data for M&E M&E Missions (internal)

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4. Implementation Arrangements

4.1 Guiding rules and regulations

Mbarara University of Science and Technology (MUST), is the second oldest public University in Uganda, and was established by an Act of Parliament of the Republic of Uganda a body corporate with perpetual succession and a common seal and with power to sue and to be sued in it's corporate name. It aims at promoting relevant and quality education in science and technology for community transformation. MUST promotes transfer of scientific knowledge and innovations to the community for sustainable society transformation. Just like any other tertiary institution in Uganda, MUST is governed by “Universities and other tertiary institutions Act, 2001 (as amended in, 2003 and as amended in, 2006), an Act of Parliament of the republic of Uganda. The University delivers both undergraduate and graduate programmes and these are accredited by the Uganda National Council for Higher Education (UNCHE). PHARMBIOTRAC will operate under the general regulations of the Mbarara University of Science and Technology (MUST). The provisions of the academic regulations of MUST empowers the University to award degrees, diplomas and certificates. It also empowers the University to withdraw such awards, if it is ascertained that the award was obtained by fraud or tainted by any act that the University believes undermines its integrity. PHARMBIOTRAC, as a semi-autonomous Centre, will be regulated by Human Resources Policies Manual, Financial Operations Policies and Procedures Manual, and will adhere to the Procurement Policy (indicated annexes) of Financial Manual (MUST). All students admitted under PHARMBIOTRAC will be subjected to the rules and regulations governing students at MUST. The University’s Legal Counsel will review all the Centre’s contracts and MoUs with partners to ensure that they are within the legal framework of the University and consistent with national and international laws. The Vice Chancellor will be signatory to all agreements. These measures will ensure that all the activities of the centre are directly under the oversight of the university and thus safeguard the Centre against fraud and corruption. The Internal Audit Department of MUST and that of the centre will routinely conduct audit functions of PHARMBIOTRAC for any forms of transactions taking place at PHARMBIOTRAC and will respond to external audit issues under the supervision of the PHRAMBIOTRAC steering committee.

4.2 Governance structures PHARMBIOTRAC governance systems, structure and roles PHARMBIOTRAC steering committee: The overall decision making organ of the center will be the PHARMBIOTRAC Steering Committee (SC) equivalent of a board that will consist of 13 persons. The Commissioner for Higher Education Ministry of Education Science, Technology and Sports will be the chair, the Vice Chancellor MUST will be the deputy chair, the members will include; Vice Chancellor BSU, Vice Chancellor GU, Director Finance and Administration (Deputy Bursar of MUST), chair learning excellence, Chair research excellence, Director NCRI, and two representatives from private sector partners, Center leader who will be secretary and Deputy center leader who will be deputy secretary. The SC will hold meetings on quarterly basis and the expenses will be met by PHARMBIOTRAC. The Vice Chancellor will report the proceedings of PHARMBIOTRAC Steering Committee and activities of PHARMBIOTRAC to the university senate and council. PHARMBIOTRAC Finance and Administration committee (F&A C): This committee shall be responsible for all financial administration and management including overseeing procurement processes. It shall consist of (8 persons), the Director Finance and Administration (Deputy Bursar, MUST), Project Accountant (MUST Senior Assistant Bursar), Internal Auditor-MUST, the Chair Learning, Chair Research, Chair Innovations and Business Management, Deputy centre leader and the centre

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leader. The centre leader shall be the chair of this committee. The F & A C shall meet as and when needed. The secretary to the committee shall be the project administrator. PHARMBIOTRAC Executive Committee (EC): The day to day management of PHARMBIOTRAC will be the EC which shall consist of 9 persons and shall have bimonthly meetings. The EC will consist of the Centre Leader who will be the chair, Deputy Centre Leader who will the deputy chair, Chair Learning Excellence, the Chair Research Excellence, the Chair Innovations and Business, the Chair Quality Assurance Learning and Research, the Director Finance and Administration, and two student representatives (one MSc and one PhD). The EC chair will report directly to the Vice Chancellor who will be updated with the center progress on monthly basis. Centre Leader: The center will have a semi-autonomous leadership and governance systems under strong and transparent center leader Dr. Casim Umba Tolo who is a Senior Lecturer at MUST and has been the Coordinator of the teams developing MUST ACE proposals. He has excellent internal and external relationships and he will also be the coordinator of all collaborations of PHARMBIOTRAC with all the partners and other stakeholders. He will directly oversee PHARMBIOTRAC and directly report to the Vice Chancellor who will in turn report to the University Council. He will also chair the PHARMBIOTRAC executive committee. He will ensure independence of PHARMBIOTRAC. To achieve this, he will ensure that the activities of PHARMBIOTRAC including appointment of staff, recruitment of students, staff and student evaluation, procurements processes etc. are in line with PHARMBIOTRAC objectives and MUST policies. He will be principal signatory to the PHARMBIOTRAC bank account that will be operated at Standard Chartered Bank with the director finance and administration and the University Secretary. Deputy Center Leader/Principal Investigator: Dr. Patrick Ogwang who is a senior lecturer with background in pharmacy and pharmacology will be Principal Investigator and the deputy center leader. He has vast experience in traditional medicine research and product development. He will be principal investigator of the PHARMBIOTRAC project overseeing and coordinating all learning, Research, Quality Assurance and Quality Control, and Business and Innovation units of PHARMBIOTRAC. He will serve as the center CEO and head of PHARMBIOTRAC secretariat, consulting and reporting directly to the center leader supported by the Project Administrator and Administrative Assistant. PHARMBIOTRAC Administrator: PHARMBIOTRAC shall hire a project administrator who will be responsible for the day-to-day administration of the secretariat. She/he shall be responsible for effective communications, logistics and protocols, recording of minutes of meetings, scheduling activities and appointments at PHARMBIOTRAC. She/he shall be responsible for prompting the various center chairs to launch their programs according to schedules etc as well as other duties that may be assigned to them from time to time by the PHARMBIOTRAC leadership. The project administrator will maintain progress reports from all sites and collaborating Institutions; review all planned activities and suggest adjustments, as necessary to the center leadership; monitor outputs and outcomes of PHARMBIOTRAC and reports to center leadership, who in turn will assess the report, advise and make recommendations. She/he shall also prepare the bi-monthly meetings of the executive committee as well as the bi-annual meetings of the Steering Committee of PHARMBIOTRAC. PHARMBIOTRAC Administrative Assistant: PHARMBIOTRAC shall hire a project administrative assistant who will be responsible for assisting the project administrator in the day-to-day running of administrative activities at the PHARMBIOTRAC secretariat. She/he shall be responsible in assisting the project administrator in keeping records, operating machines for photocopying, duplicating, binding, and filing documents. She/he shall be responsible for collection and delivery of mail and other materials as required from and to the post office, government agencies and other institutions. She/he shall be responsible for sorting, delivery and pick up of mail from various offices and any other duties as required. Justification for hiring PHARMBIOTRAC Administrator and Administrative Assistant:

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Hiring of these two individuals is highly justified given the complex nature of the interactions expected to yield success for PHARMBIOTRAC. The roles to be played by the project administrator and administrative assistant at PHARMBIOTRAC secretariat cannot be underestimated especially that these roles cannot be played by current MUST staff due to the fact that PHARMBIOTRAC involves 20 institutions (national, regional and international) and a large array of potential industrial partners. It is envisaged that these organizations would need to be engaged and constantly interacted with in order to create a firm and effective communication system and coordinated PHARMBIOTRAC activities between and among partners. Such engagement would need full time attention without competing assignments that may gain priority over PHARMBIOTRAC activities. Furthermore, funding for the PHARMBIOTRAC will be received from the World Bank based on Disbursement Linked Indicators (DLIs)/ Disbursement Linked Results (DLRs) fulfilment. The achievement of these results is monitored by indicators of performance (i.e. DLIs/DLRs). The PHARMBIOTRAC secretariat would help focus on results exclusively by monitoring progress on the achievement of the indicators agreed in the project’s Implementation Plan (IP). This job requires dedicated attention and a strong liaison among PHARMBIOTRAC partners who have to learn a new PHARMBIOTRAC organizational culture with efficiencies designed to be improvements on existing structures within most partner institutions. Therefore, hiring PHARMBIOTRAC financed staff would mitigate against the institutional factors that may hinder project implementation success. Chair, Learning Excellence: Prof. Amon G. Agaba who chair a team of faculty responsible for the academic programs of the center, including technical guidance on curriculum development, teaching excellence, teaching planning, examination etc. He is credited with initiating a new program at MUST in pharmaceutical sciences funded by World Bank under millennium science initiative. The chair shall report all the activities to the Principal Investigator/Deputy Center leader. Chair Research Excellence: Dr. Juliet Mwanga-Amumpaire will chair a team of faculty, students and laboratory personnel responsible for all research programs including joint research projects with regional and international partners. She is currently the Director Epicenter Research Centre Uganda of Médecins Sans Frontières (MSF) International (doctors without borders) based at MUST. This center is a world class research laboratory for disease surveillance and clinical studies. This laboratory will also be utilised by PHARMBIOTRAC students for their training and research activities. The chair and her team will ensure that all research projects and activities are approved by the Faculty Research and Ethics Committee (FREC), Institutional Review Board/Research Ethics Committee (REC) and also registration with the Uganda National Council for Science and Technology (UNCST). They will oversee and coordinate research program of the PHARMBIOTRAC including research proposal development research planning, research implementation and management, research output dissemination etc. This team representation will be drawn from each of the Key partner Institutions including private sector or industry. It shall include at least 2 members from Traditional Medicine partners. The chair shall report all the activities to the Principal Investigator/Deputy Center leader. Chair Learning and Research Quality Assurance: Dr. Esther Ankunda: will chair a team overseeing quality of center’ research and teaching including; student and staff performance, proposal quality, publication quality, products quality etc. The chair will work hand in hand with the PHARMBIOTRAC consultant for QAC and M&E. The chair shall report all the activities to the Principal Investigator/Deputy Center leader. Chair Innovation & Business Management: Eng. Anke Weisheit: will chair team consisting mainly of representatives private sector Cipla/QCL, Kazire Healthcare Products Ltd, Excel Hort Consult, NCRI. They will oversee the key areas of entrepreneurship, innovation incubation, and knowledge / technology commercialization, product development and commercialisation, licensing and patenting etc. The chair shall report all the activities to the Principal Investigator/Deputy Center leader. Director Finance and Administration: Mr. Dominique Musana will oversee all the cash flow, financial management, funds allocation tools and procedures, procurement supervision etc. Ensure that these

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are in line with MUST policies and World Bank procedures. The Financial Management and Administration Structure of the PHARMBIOTRAC shall be headed by the Project’s Director Finance and Administration who is the University Deputy Bursar Mr. Dominique Musana. Mr. Dominique Musana will oversee all the cash flow, financial management, funds allocation tools and procedures, procurement supervision etc., and ensure that these are in line with MUST policies and World Bank guidelines and procedures. The Project’s Director Finance and Administration shall report to University Secretary who is the Accounting officer of Mbarara University of Science and Technology (MUST) and the centre leader. There shall be two Project Accountants for PHARMBIOTRAC, the first one being the University Senior Assistant Bursar Mr. Francis Ndyaguma. He shall report to the Director Finance and Administration who in turn will report to the University Secretary (Accounting officer, MUST) and the center leader. In addition, there shall be a second Project Accountant for PHARMBIOTRAC who shall be hired as per the recommendations by Ministry of Finance, Planning and Economic Development of the Republic of Uganda, and the World Bank during negotiations. The Project’s Director Finance and Administration shall supervise the two Accountants whose job descriptions shall be elaborated later on with clear terms of reference, but well before the Project’s Implementation commences. Other financial support functions including internal auditing shall be handled using the existing structures of the University. Financial transactions of the Project shall be maintained by Quick books software which generates reports such as income and expenditure statements. Authorization and approval of project transactions shall follow the University‘s established structures. However, the center leader shall be the principal signatory to the PHARMBIOTRAC bank account that will be operated at Standard Chartered Bank with the director finance and administration and the University Secretary as co-signatories. Stakeholder’s annual General meeting and scientific conference: This shall be held once a year to present to center’s performance to stakeholders and invite their suggestions on areas of improvement. The stakeholders shall include all national, regional and international partners of PHARMBIOTRAC, government line ministries from Uganda and regional countries, selected private sector, other universities in the region, civil society organizations, media houses etc. Contacts between Center Leadership and staff of World Bank Office in , Uganda Contact has been made with Dr. Peter Okwero and appointment made to meet with him. The team will also propose a biannual meeting with Health and Education Office and counterparts at the World Bank Office in Kampala, for updating, guidance and assistance with financial or procurement challenges. This however, will be augmented by calls to the officers as and when need arises.

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4.3 Organizational Chart

4.4 Project team Roles and responsibilities Table 6: Overview of core project team: Name Discipline Project Responsibility title/Role Dr. Casim Biology (Animal Centre Leader Overall leadership and Partnerships and Umba Tolo, Physiology / external relations, teaching / students PhD Ecology) supervision and mentoring Dr. Patrick Pharmacy / Deputy Centre Principal Investigator and day to day oversight Engeu Experimental Leader / operations, teaching / students’ supervision Ogwang, PhD Pharmacology and mentoring. Oversee and coordinate training and research programs of the center, including research proposal development, research planning, research implementation and management, research output dissemination including publications and conference presentations. Prof. Amon G. Medicine / Chair Learning Responsible for the academic programs of the Agaba, PhD Clinical Excellence center, including technical guidance on Pharmacology curriculum development, teaching excellence, teaching planning, examination etc. Associate Medicine / Chair Research Chair research presentations by the staff and Professor paediatrics / Excellence students and approval of research grants,

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Name Discipline Project Responsibility title/Role Juliet community research outputs and research dissemination of Mwanga- health outreach the center. Amumpaire, MMed Dr. Esther Chair Learning Overseeing quality of center’s research and Ankunda, Public Health and Research teaching including; student and staff PhD Quality performance, proposal quality, publication Assurance quality, products quality, teaching / students supervision and mentoring Eng. Anke Traditional Chair Attracting business partnerships and funding to Weisheit, Medicine, Innovation and the center, Oversee the key areas of M.Sc. Business and Business entrepreneurship, innovation incubation, and Innovation, Management knowledge / technology, linking with private linkage to sector and traditional medical practitioners, Traditional community outreach, commercialization, Medical licensing, royalty and patenting. Practitioners Mr. Finance / Director Oversee all the cash flow, financial management Dominique Administration Finance and and administration, funds allocation tools and Musana, Administration procedures, procurement supervision and CPA(U) ensure that these are in line with MUST policies and World Bank guidelines and procedures.

4.5 Incentive structures PHARMBIOTRAC will put in place incentive and a motivation structure that encourages students, academic and non-academic staff as long as they work for the centre and their work/activities are deemed to contribute significantly to the achievement of the milestones set for the project. Academic staff incentives will include attachment to regional and international laboratories of partner institutions, but also to other relevant institutions/industries to enable them acquire new and needed skills and expertise. Additionally, PHARMBIOTRAC will encourage and support participation at international conferences of its faculty, staff and students as a way of international exposure and gaining experiences elsewhere in the world, especially outside Africa, hence promoting excellence and knowledge sharing. It is expected that faculty will also benefit through supervision of student research and publications in peer reviewed journals with publication fees covered by PHARMBIOTRAC. Publications are prerequisite for career development and promotion in our university and will be a significant motivator for faculty involvement in PHARMBIOTRAC activities. In addition, an attractive research policy to be developed will include benefit sharing of innovation and patents by faculty and staff and the institution which shall include; royalties from patents. Some of the more specific incentives that will be offered to faculty and project staff are outlined in Table 7 below:

Table 7: Incentive system Project Discipline Motivating factors Incentive required/ offered title/Role Centre Leader (Dr. Biology Recognition for 1. Attachment to regional and international Casim Umba Tolo) (Animal leadership, laboratories/institutions/industries to Physiology/ responsibility and acquire new and needed skills and expertise, Ecology) achievement e.g. WPI (USA), Gezira University (Sudan). 2. Participation at international benchmarking exercises for best practices to

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Project Discipline Motivating factors Incentive required/ offered title/Role promote excellence at PHARMBIOTRAC 3. Participation at international conferences (4 per year). 4. Payment for publications fees in peer reviewed journals. 5. Promotion by the institution resulting from student supervision and publications. Deputy Centre Pharmacy / Recognition for 1. Participation at international Leader Experimental leadership, benchmarking exercises for best practices to (Dr. Patrick Pharmacology responsibility and promote excellence at PHARMBIOTRAC Ogwang) advancement of the 2. Attachment to regional and international pharmacy profession laboratories/institutions/industries to acquire new and needed skills and expertise, e.g. WPI (USA), ITHST-FRLHT (India), KEMRI (Kenya), China. 3. Participation at international conferences (4 per year). 5. Payment for publications fees in peer reviewed journals. 6. Promotion by the institution resulting from student supervision and publications. Vice Chancellor, Medicine/ Recognition for 1. Participation at international MUST (Prof. Clinical achievement as a top benchmarking exercises for best practices to Celestine Obua) Pharmacology administrator and a promote excellence at PHARMBIOTRAC. led/senior mentor for 2. Participation at international level with the PHARMBIOTRAC partners in policy dialogue and signing of implementing team, MOUs for PHARMBIOTRAC. and advancement of 3. Participation at international conferences the pharmacy (2 per year). profession 4. Payment for publications fees in peer reviewed journals. Chair Learning Medicine / Recognition for 1. Participation at international Excellence Clinical achievement because benchmarking exercises for best practices to (Prof. Amon Pharmacology the PHARMBIOTRAC promote excellence at PHARMBIOTRAC Agaba) builds on Bachelor of 2. Participation at international conferences Pharmaceutical (2 per year). Sciences initiated by 3. Payment for publications fees in peer him in 2009 reviewed journals. Chair Research Medicine / Recognition for 1. Attachment to regional and international Excellence (Assoc paediatrics / achievement, and hospitals/health facilities/ institutions to Prof. Juliet community responsibility acquire new and further clinical trial Mwanga) health experiences, e.g. ITHST-FRLHT (India), outreach KEMRI (Kenya), China, UKZN (South Africa). 2. Participation at international conferences (2 per year). 3. Payment for publications fees in peer reviewed journals. 4. Promotion by the institution resulting from student supervision and publications. Chair Learning Nursing / Recognition for 1. Attachment to regional and international and Research Public Health achievement, and hospitals/health facilities/ institutions to Quality Assurance responsibility acquire new and further clinical trial (Dr. Esther experiences, e.g., UKZN (South Africa), ITHST- Atukunda) FRLHT (India), KEMRI (Kenya), China.

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Project Discipline Motivating factors Incentive required/ offered title/Role 2. Participation at international conferences (2 per year). 3. Payment for publications fees in peer reviewed journals. 4. Promotion by the institution resulting from student supervision and publications. Head Pharmacology Recognition for 1. Participation at international conferences Pharmacology achievement, (1 per year). (Assoc Prof. Paul responsibility, and 2. Payment for publications fees in peer Alele) advancement of the reviewed journals. pharmacy profession 3. Promotion by the institution resulting from student supervision and publications. Head Microbiology Recognition for 1. Participation at international conferences Microbiology achievement, and (1 per year). (Dr. Joel Bazira) responsibility 2. Payment for publications fees in peer reviewed journals. 3. Promotion by the institution resulting from student supervision and publications. Head Pathology Pathology Recognition for 1. Participation at international conferences (Prof. Damarias achievement, and (1 per year). Lafita) responsibility 2. Payment for publications fees in peer reviewed journals. Head Biochemistry Recognition for 1. Participation at international conferences Biochemistry achievement, and (1 per year). (Assoc Prof. responsibility 2. Payment for publications fees in peer Gertrude reviewed journals. Kiwanuka 3. Promotion by the institution resulting from Nakiwala) student supervision and publications. Head Physiology Physiology Recognition for 1. Participation at international conferences (Prof. Nosmo achievement, and (1 per year). Mukiibi) responsibility 2. Payment for publications fees in peer reviewed journals. Head Anatomy Anatomy Recognition for 1. Participation at international conferences (Dr. Grace achievement, and (1 per year). Mwanga) responsibility 2. Payment for publications fees in peer reviewed journals. 3. Promotion by the institution resulting from student supervision and publications. Head Community Community Recognition for 1. Participation at international conferences Health health achievement, and (1 per year). (Assoc Prof. Edgar responsibility 2. Payment for publications fees in peer Mulogo) reviewed journals. 3. Promotion by the institution resulting from student supervision and publications. Head Pharmacy Pharmacy Recognition for 1. Participation at international conferences (Assoc Prof. achievement, (1 per year). Genny responsibility, and 2. Payment for publications fees in peer Dominguez) advancement of the reviewed journals. pharmacy profession 3. Promotion by the institution resulting from student supervision and publications. Head Pharmaceutica Recognition for 1. Attachment to regional and international Pharmaceutical l sciences achievement, laboratories/institutions/industries to Sciences responsibility, and acquire new and needed skills and expertise, (Dr. Duncan advancement of the e.g. USA, China, KEMRI (Kenya),

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Project Discipline Motivating factors Incentive required/ offered title/Role Ssesazi) pharmacy profession 2. Participation at international conferences (1 per year). 3. Payment for publications fees in peer reviewed journals. 4. Promotion by the institution resulting from student supervision and publications. Head Botany and Recognition for 1. Attachment to regional and international Ethnobotanist taxonomy achievement, Universities/herbaria/museums & other (Dr. Eunice Olet) responsibility, and institutions to acquire new and further herbal advancement of the plant identification experiences, e.g., UKZN pharmacy profession (South Africa), ITHST-FRLHT (India), China. 2. Participation at international conferences (1 per year). 3. Payment for publications fees in peer reviewed journals. 4. Promotion by the institution resulting from student supervision and publications. Head Biotechnology Recognition for 1. Participation at international conferences Biotechnology achievement, (1 per year). (TBD) responsibility, and 2. Payment for publications fees in peer advancement of the reviewed journals. pharmacy profession 3. Promotion by the institution resulting from student supervision and publications. Head Traditional Traditional/ Recognition for 1. Participation at international conferences Medicine Natural achievement, (1 per year). (TBD) medicines responsibility, and 2. Payment for publications fees in peer advancement of the reviewed journals. pharmacy profession 3. Promotion by the institution resulting from student supervision and publications. Chair Innovation Traditional Recognition for 1. Salary and career growth and Business Medicine, achievement, and 2. Participation at international conferences Management Business and responsibility (2 per year) and participation in international (Eng. Anke Innovation, Expo and Trade fairs (2 per year) Weisheit) linkage to TM 3. Payment for publications fees in peer Prctitioners reviewed journals.

Director Finance Finance / Recognition for 1.Career growth in large grant management and Administration achievement, and 2. Participation at international Administration responsibility benchmarking exercises for best practices to (Mr. Dominique promote excellence at PHARMBIOTRAC Musana) Project Administration Recognition for Salary and career growth Administrator achievement, and (to be recruited) responsibility Administrative Administration Recognition for Salary and career growth Assistant achievement, and (to be recruited) responsibility Internal audit Auditing Recognition for Career growth in large grant management (MUST) achievement, and Participation at international benchmarking responsibility exercises for best practices to promote excellence at PHARMBIOTRAC Project Accounting Recognition for Salary and career growth Accountant achievement, and (Mr. Francis responsibility

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Project Discipline Motivating factors Incentive required/ offered title/Role Ndyaguma) Project Accounting Recognition for Salary and career growth Accountant II (to achievement, and be recruited) responsibility Procurement Procurement Recognition for Salary and career growth Assistant / achievement, and secretary (to be responsibility recruited) Lab technician Laboratory Recognition for Salary and career growth (to be recruited) science achievement, and responsibility Driver transport Recognition for Salary and career growth (to be recruited) achievement, and responsibility Cleaner ------Recognition Salary (to be recruited)

4.6 Environment safeguards Environmental Management Plan from safeguard screening and disclosed on your website, please list responsible staff see Online available: http://www.must.ac.ug/downloads/MUST%20PHARMTRAC%20ESMP_15_01_2015.pdf

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5. Performance Monitoring Table 8: Overview of Disbursement Linked Indicators (DLI) and Disbursement Linked Results (DLR)

Disbursement Linked Action to be Completed Definition Disbursement Indicators Calculation Formula (Can trigger maximum 6 (expressed in USD million USD equivalent ) equivalent) DLI #1: Institutional DLR#1.1: To meet Conditions for Disbursed when all conditions for effectiveness outlined in the legal DLR#1.1: readiness Effectiveness agreements signed between the ACE hosting government and the World 600,000 Ban Total amount 1,100,000 DLR#1.2: Development of Disbursed when detailed implementation plan of ACE is approved by the DLR#1.2: (expressed in USD detailed implementation plans ministry in charge of higher education as part of the Performance 500,000 equivalent) Agreement. DLI #2: Excellence in DLR# 2.1: Timely annual Disbursement based on the achievement of at least 50% and scalable up to DLR#2.1: education and research implementation of the plans 85% of implementation targets in any given year. Achievement rates 500,000 capacity and beyond 85% in any given year triggers a 100% disbursement of that year development impact DLR #2.2: Newly enrolled Short-Term Courses: Disbursement occurs when any course leading to DLR#2.2: 1,200,000 Total amount 4,300,000 students in the ACE of which at qualification (certificate/diploma /degree) counts as a short-term course: (expressed in USD least 20% must be regional 400 per male national student equivalent) (African) students. 500 per female national student 800 per male regional student 1,000 per female regional student. Master’s: Disbursement occurs when Master’s students have successfully completed at least one semester: 2,500 per male nationa1 student 3,000 per female national student 4,500 per male regional student 5,500 per female regional student. PhD: Disbursement occurs when PhD students enrol: 12,000 per male national student 15,000 per female national student 25,000 per male regional student 30,000 per female regional student. Disbursement for academic accomplishment will occur upon the student’s successful completion of a Master’s program or the approval of a student’s 36 | Page

Disbursement Linked Action to be Completed Definition Disbursement Indicators Calculation Formula (Can trigger maximum 6 (expressed in USD million USD equivalent ) equivalent) PhD research proposal. The amount triggered will be half of the above indicated in each category, totalling for not more than 300,000. DLR#2.3: Accreditation of quality Disbursement occurs when a Master or PhD program is accredited by DLR# 2.3: of education programs. international or regional or national body (satisfactory to the World Bank): 600,000 300,000 per program internationally accredited 150,000 per program regionally accredited 75,000 per program nationally accredited 75,000 per program for self-evaluation (satisfactory executed according to internationally recognized standard). Self-evaluation and national accreditation, totalling for not more than 300,000. DLR#2.4: Collaboration and Disbursement occurs when MoUs are signed and accompanied by signed DLR#2.4: partnerships for applied research proposals that outline at least a two-year collaboration and partnership 200,000 and training work-program: 30,000 per MoU with public institutions/civil society 40,000 per MoU with private sector/ industry In order to access the disbursement under this DLR minimum 1 eligible MoU with private sector must be approved. All MoU work programs must be satisfactory to IUCEA/World Bank. DLR#2.5: Peer-reviewed journals Disbursement occurs when a paper is accepted by a peer-review journal or DLR#2.5: papers or peer-reviewed is an accepted peer-reviewed conference paper: 300,000 conference papers 30,000 per paper accepted by a peer-reviewed journal 20,000 per accepted peer-reviewed conference paper. DLR#2.6: Faculty and PhD This DLR is awarded to the ACE when it hosts faculty/PhD students from DLR#2.6: student exchanges to promote other institutions or when it sends its faculty/PhD students to other 500,000 regional research and teaching institutions; locally, in the region or internationally for a “period” of minimum two weeks (for teaching/research collaboration): 5,000 per “period” within the country 10,000 per “period” within the region 8,000 per “period” for international. DLR#2.7: External revenue Externally generated revenue deposited into the ACE’s account from tuition DLR#2.7: generation fees, other student fees, sale of consultancies, joint research, fund raising 900,000 and donations, or other external sources: US$1 per externally generated

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Disbursement Linked Action to be Completed Definition Disbursement Indicators Calculation Formula (Can trigger maximum 6 (expressed in USD million USD equivalent ) equivalent) US$1 from national sources, and US$2 per externally generated US$1 from regional and international sources. DLR#2.8: Institution participating The DLR will be disbursed if the ACE hosting university participate in the DLR#2.8: in benchmarking exercise Partnership of Applied Sciences, Engineering and Technology (PASET) 100,000 benchmarking exercise. DLI#3: Timely, DLR#3.1: Timely Withdrawal DLR#3.1: transparent and Application supported by 15,000 per year institutionally reviewed financial reporting on the ACE Financial Management account for the period Total amount 300,000 DLR#3.2: Functioning Audit DLR#3.2: (expressed in USD Committee under the university 15,000 per year equivalent) council DLR#3.3: Functioning internal DLR#3.3: audit unit for the university 15,000 per year

DLR#3.4: Transparency of DLR#3.4: financial management (audit 15,000 per year reports, interim financial reports, budgets and annual work plan are all web accessible) DLI#4: Timely and DLR# 4.1 Timely procurement DLR#4.1: audited Procurement audit report 30,000 per year Total amount 300,000 DLR#4.2: Timely and satisfactory DLR#4.2: (expressed in USD procurement progress report 30,000 per year equivalent) Note:  Any enrolment occurred after 1st August, 2016 will be counted towards the DLIs in the first year.  Regional student is interpreted as students from Africa.  Total disbursement is limited to the overall amount of financing to each ACE, which will be confirmed after negotiations.  DLI amounts will be proportionately allocated based on the total financing for that ACE.

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Table 9: Example of a monitoring spreadsheet in Excel. Detailed activity DLIs Results Activities sheets (actions) Time Money When (order or (order or (Months, Currency (order or sequence) sequence) sequence) days) e.g. (Local??) Dates DAS 1 (Months) 2 DAS 2 (Days) 10 Activity 1 DAS 3 (Months) 3 DAS 4 (Days) 6 DAS 5 (Days) 9 DAS 1 (Days) 12 Result 1 (Narrative Activity 2 DAS 2 (Months) 1 DLI 1 and measurement) (Narrative DAS 1 (Days) 56 and DAS 2 (Days) 35 Activity 3 Measurement DAS 3 (Days) 14 ) DAS 4 (Days) 89 Repeat DAS 1 (Days) 24 Activity 4 section for as DAS 2 (Days) 261 many DLIs as Activity 1 available Activity 2 Result 2 Activity 3 Activity 4 Activity 1 Activity 2 Result 3 Activity 3 Activity 4 Verification WB/ ACE ACE Component AAU Director/ DIRECTOR/PA Implementation AAU RTNER Leader LEADER

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6. Budget

6.1 Summary Budget allocation Allocation Amount in USD Amount in Percentage (%) International Partners 649,425 10.82% National Partners 254,000 4.23% ACE Host 5,096,575 84.94% Total 6,000,000 100%

6.2 Detailed Budget

Table 10: Budget, Project year 1 – 5 with split between host and consortium partners

Estimated Costs in (US$) Expenditure Category %of Y 1 Y 2 Y 3 Y 4 Y 5 Total total A: Budget by Activity Plan 5.1 Action Plan for Learning 467,290 391,840 473,640 390,040 199,840 2,076,645 34.61 Excellence 5.2 Action Plan for Research 718,240 260,806 329,636 215,906 159,456 1,807,039 30.12 Excellence 5.3 ACE Action Plan for Quality 12,000 6,600 6,600 6,600 6,600 38,300 0.64 Assurance 5.4 ACE Action Plan regarding 6,565 4,283 10,000 0.17 Equity Dimensions 5.5 ACE Action Plan for Attracting Academic Staff and 54,000 54,000 54,000 54,000 54,000 260,000 4.33 Students from the Region 5.6 ACE Action Plan for National and Regional Academic 194,410 98,410 53,560 53,560 53,560 489,500 8.16 Partners 5.7 ACE Action Plan for National 56,300 98,300 8,300 8,300 8,300 89,500 1.49 and Regional Sector Partners 5.8 ACE Action Plan for Collaboration with 38,060 38,060 38,060 16,760 16,760 146,800 2.45 International Academic Partners 5.9 ACE Action Plan for 148,301 80,660 80,660 80,660 80,660 734,926 12.25 Management and Governance 5.10 ACE Action Plan for 70,360 62,710 62,710 62,710 62,710 311,020 5.18 Sustainable Financing 5.11 ACE Action Plan for 20,470 4,000 4,000 4,000 4,000 36,270 0.60 Monitoring and Evaluation TOTAL 1,785,996 1,095,386 1,111,166 896,819 645,886 6,000,000 100.00 B: Budget by partners

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%of YR 1 YR 2 YR3 YR 4 YR5 Total Expenditure Category total Peer Universities - National Bishop Stuart University 21,770 7,470 8,220 7,470 7,020 51,950 0.87 Gulu University 22,920 8,120 9,120 8,120 7,520 55,800 0.93 Makerere University, College of 4,360 3,760 3,760 3,760 3,260 18,900 0.32 Natural Sciences Uganda Technology and 4,360 3,760 3,760 3,760 3,260 18,900 0.32 Management University Subtotal 53,410 23,110 24,860 23,110 21,060 145,550 2.43 Peer Universities - Regional University of KwaZulu Natal - 8,910 8,910 8,910 8,910 7,410 43,050 0.72 South Africa University of Gezira - Sudan 45,910 51,160 51,160 35,110 17,910 201,250 3.35 Universidade Católica de 8,860 8,860 8,860 8,860 7,410 42,850 0.71 Moçambique - Mozambique Subtotal 63,680 68,930 68,930 52,880 32,730 287,150 4.79 Peer Universities -

International Worcester Polytechnic Institute 19,965 19,965 19,965 12,190 9,090 81,175 1.35 - USA Institute of Trans-disciplinary Health Sciences and Technology 14,540 14,540 14,540 8,990 7,490 60,100 1.00 (Transdisciplinary University) - India Subtotal 34,505 34,505 34,505 21,180 16,580 141,275 2.35 Advanced Knowledge

Institutions - Regional Kenya Medical Research 43,260 47,810 47,810 32,210 16,910 188,000 3.13 Institute, Centre for Traditional Medicine and Drug Research, Kenya Subtotal 43,260 47,810 47,810 32,210 16,910 188,000 3.13 Research Institutions -

National Natural Chemotherapeutics 1,100 2,300 2,300 2,300 1,800 9,800 0.16 Research Institute Subtotal 1,100 2,300 2,300 2,300 1,800 9,800 0.16 Private Sector – National CIPLA Quality Chemical 1,200 2,300 2,300 2,300 1,800 9,900 0.17 Industries Limited Uganda Excel Hort Consult Ltd 900 2,250 2,250 2,250 1,800 9,450 0.16 Kazire Health Products Ltd 450 1,650 1,650 1,650 1,200 6,600 0.11 Subtotal 2,550 6,200 6,200 6,200 4,800 25,950 0.43 Others - National Bushenyi Medical & Traditional 50,450 3,650 3,650 3,650 3,200 64,600 1.08 Healers Association Uganda National Council for 600 2,000 2,000 2,000 1,500 8,100 0.14 Science and Technology Subtotal 51,050 5,650 5,650 5,650 4,700 72,700 1.21 Others - Regional Regional Universities Forum for 3,600 3,000 3,000 3,000 1,000 13,600 0.23 Capacity Building in Agriculture African Institute for Capacity 4,250 4,050 4,050 4,050 3,000 19,400 0.32 Development

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Subtotal 7,850 7,050 7,050 7,050 4,000 33,000 0.55 Total for Partner Institutions 257,405 195,555 197,305 150,580 102,580 903,425 15.06 MUST (HOST Institution) 1,613,471 912,156 1,050,386 894,056 626,506 5,096,575 84.94 TOTAL (MUST + Partners) 1,870,876 1,107,711 1,247,691 1,044,636 729,086 6,000,000 100.00

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7. Detailed Activity Sheets Action Plan 8.1 Learning Excellence Timeframe: Quart 1 of Year 1 Activity: Training high quality cadres in the field of pharmbiotechnology and traditional medicine Table 11: Action Plan Learning Excellence RESULT Best practices benchmarked from USA, India and South Africa ACTIVITY 8.1.1 Benchmarking best practices in pharmbiotechnology and Traditional Medicine in selected Institutions and industry 8.1.2 Establishment of Curriculum review/ Development teams 8.1.3 Development of curriculum for short courses, and new MSc and PhD 8.1.4 Stakeholders and partners meeting to appraise revised and new curriculum 8.1.5 Submission for Curriculum accreditation 8.1.6 Upgrading Learning Facilities/ Digital Library / ICT learning centre / video conferencing facilities/ computer workstations for students 8.1.7 Development/acquisition of learning materials (lecturer’s reference materials, demonstration materials, Student Handbooks (PhD & Masters) 8.1.8 Procurement of a 30 seater Bus for field student activities 8.1.9 Advertisement/ assembling of trainers/ Recruitment of students for short courses and training. 8.1.10 Advertisement/ assembling of trainers and doctoral committees including industry experts for MSc and PhD, and training 8.1.11 Field and Industry placement of students and staff 8.1.12 Involvement of External examiners in field and industry placement evaluation and Theses defence. 8.1.13 Student presentation at doctoral committees and conferences 8.1.14 Annual dissemination conference and Annual general meeting of all stakeholders OUTPUT 8.1.1-8.1.4 Best practices benchmarked, existing curriculum reviewed and curriculum for new courses developed. 8.1.5 Revised Curricula and 2 new MSc courses curricula accredited 8.1.6 Learning Facilities/ Digital Library / ICT learning centre upgraded 8.1.7 Learning materials developed/acquired. 8.1.8 A 30 seater Bus for field student activities procured. 8.1.9 Short courses advertised, trainees recruited and training initiated. 8.1.10 Doctoral and MSc programs advertised, learning and doctoral committees formed and learning started. 8.1.11 students and staff acquired practical experience and skills from partner institutions /industry during placements. 8.1.12 Appraisals by External examiners on the field and industry placements and Theses quality. 8.1.13 Students gained presentation skills at doctoral committee level, national and international conferences 8.1.14 Annual dissemination conference and general meeting held for all partners and stakeholders. OUTPUT INDICATOR SOURCE OF VERIFICATION 8.1.1-8.1.4 Number of curricula for new courses. 8.1.1-8.1.4 curricula document and 8.1.5 Number of Curricula for new MSc courses prospectus at University records. accredited 8.1.5 Letters of Curricula accreditation 8.1.6 Number of Learning Facilities/ Digital Library / at University records 43 | Page

ICT learning centre upgraded 8.1.6 Availability and usage Learning 8.1.7 Number and types Learning materials Facilities/ Digital Library / ICT learning developed/acquired. centre upgraded 8.1.8 Number and capacity Bus for field student 8.1.7 Learning materials available. activities procured. 8.1.8 Bus for field student activities 8.1.9 Number of Short courses adverts run, number of available and used. trainees recruited, number of short trainings done and 8.1.9 Adverts copies, records of trainees number of students completing short courses. recruited, Records of short trainings done, 8.1.10 Number of Doctoral and MSc programs adverts attendance records and copies of short runs, Number of learning and doctoral committees courses certificates. formed and learning teams running. 8.1.10 Copies of Doctoral and MSc 8.1.11 Number of students and staff with practical programs adverts run, records of learning experience and skills from partner institutions teams and doctoral committee’s activities. /industry during placements. 8.1.11 Records of students and staff 8.1.12 Number of Appraisal reports by External placed for practical experience and skills examiners on the field and industry placements and from partner institutions /industry. Theses quality. 8.1.12 Record and copies of appraisals 8.1.13 Number of presentations by Students at reports by External examiners on the field doctoral seminars, national and international and industry placements and Theses conferences quality. 8.1.14 Number of national, regional and international 8.1.13 Conference proceedings participants registered and papers presented at Annual 8.1.14 Annual conference proceedings and dissemination conference and general meeting. record of participants and minutes of Annual General meeting IMPLEMENTATION 8.1.1-8.1.4 Best practices benchmarked, existing curriculum reviewed and MILESTONES curriculum for new courses developed by 31/5/2016 8.1.5 Revised Curricula and 2 new MSc courses curricula accredited by 31/8/2016 8.1.6 Learning Facilities/ Digital Library / ICT learning centre upgraded byb31/8/2016 8.1.7 Learning materials developed/acquired by 31/8/2016. 8.1.8 A 30 seater Bus for field student activities procured by 31/1/2017 8.1.9 Short courses advertised, trainees recruited and training initiated by 1/7/2016 8.1.10 Doctoral and MSc programs advertised, learning and doctoral committees formed and learning started by 31/8/2016 8.1.11 students and staff acquiring practical experience and skills from partner institutions /industry during placements 15/12/2016 to 15/2/2017 8.1.12 Appraisals by External examiners on the field and industry placements and Theses quality by 31/5/2017 8.1.13 Students gained presentation skills at doctoral committee level, national and international conferences by 1/12/2016, 31/3/2017, 31/5/2015 8.1.14 Annual dissemination conference and general meeting held for all partners and stakeholders 31/12/2016 PROCUREMENT RESPONSIBILITY FOR Internal: IMPLEMENTATION Centre Leader – Dr. Casim Umba Tolo

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Deputy Centre Leader - Dr. Patrick Ogwang Chair Learning excellence - Prof. Amon Agaba Chair Innovation and Business Management – Eng. Anke Weisheit Head Pharmacology - Assoc Prof. Paul Alele Head Pharmacy - Assoc Prof. Genny Dominguez Head Microbiology - Dr. Joel Bazira Head Pathology – Prof. Damarias Lafita Head Physiology - Prof. Nosmo Mukiibi head Biochemistry - Prof. Gertrude Kiwanuka Nakiwala Head Community Health Centre - Assoc Prof. Edgar Mulogo Head Botany - Dr. Eunice Olet Head Chemistry - Dr. Grace Birungi, Anlytical Chemistry National Academic Partners: Prof. Maud Kamatenesi, Ethnobotanist, Bishop Stuart University Prof. Hannington Oryem Origa, Plant Physiologist, Makarere University, Kampala, Uganda Dr. Alice Lamunu, Clinical Pharmacist, Gulu University, Uganda Regional and International Academic Partners: Prof. Dominic Byarugaba, Ethnobotanist, African institute for Capacity Development, Nairobi, Kenya Dr. Festus Tolo, Medicinal Phytobiologist, Kenya Medical Research Institute, Kenya Dr. Mai Abdalla, Plant Pathologist, University of Gezira, Sudan Prof Padma Venkat, Ayuvedia and Genomics, Trans-Disciplinary University, India Dr. Ashwini Godbole, Ayurvedia and neurodegenerative disorders, Trans- Disciplinary University, India Dr. Vijayalakshmi Babu, Ayurvedia and pharmbiotechnolgy, Trans- Disciplinary University, India Prof. Pamela Weather, Plant Biologist and biotechnologist, Worcester Polytechnic Institute, USA Prof. Kamal Rashid, Biomanufacturing and Education, Worcester Polytechnic Institute, USA Prof. Roy Hegedus, Bioprocess Lab, Worcester Polytechnic Institute, USA Prof. Susan Roberts, has expressed interest cell cultures for cancer drugs, Worcester Polytechnic Institute, USA DURATION: 12 months Commencement: 31/5/2016 Completion: 31/5/2017 PRIMARY CONSTITUENTS: Centre PARTICIPANTS: Broader university staff, partners, faculty, support staff and students Communities, Professional councils and regulatory bodies. ASSUMPTIONS 1. Project approved by May 2016 2. Memorandum of Understanding (MoUs) with partners signed by May 2016 3. National and Regional stability 4. Revised and new Curricula accreditation expedited 5. Timely disbursement of funds FINANCIAL IMPLICATIONS 2,076,645USD Budget Line Analysis First Year Y Y Y Y Total 45 | Page

2 3 4 5 USD

Q1 Q2 Q3 Q4 5.1.1 Benchmarking visits (India) 35,360 - - - - 35,360 5.1.2 Benchmarking visits (South Africa) 29,290 - - - - 29,290 5.1.3 Benchmarking visits (USA) 37,995 - - - - 37,995 5.1.4 Establishment of learning teams 1,000 1,000 1,000 1,000 1,000 5,000 5.1.5 Installation of ICT systems for 10,000 3,000 3,000 3,000 3,000 22,000 learning 5.1.6 Curriculum development (Short 20,400 - - - - 20,400 courses MSc & PHD ) 5.1.7 Curriculum accreditation (Fast Track 16,000 - - - - 16,000 fees) 5.1.8 Student Handbooks (PhD & Masters) 340 340 340 340 340 1,700 5.1.9 Learning materials (lecturers 6,000 6,000 6,000 6,000 6,000 30,000 reference materials, demonstration materials etc.) 5.1.10 Upgrading Learning Facilities 70,000 - - - - 70,000 Pharmacy (production unit) 5.1.11 Lecture room upgrade 12,000 - - - - 12,000 5.1.12 Digital Library / ICT learning centre / 50,000 2,500 2,500 2,500 2,500 60,000 video conferencing facilities/ computer workstations for students 5.1.13 Standby generator (purchase & 10,000 - - - - 10,000 installation) 5.1.14 Fuel and maintenance 900 900 900 900 3,600 3,600 3,600 3,600 18,000 5.1.15 Chair Learning Excellence 220 110 220 110 660 660 660 660 3,300 coordination 5.1.16 Advertisement/ assembling of 2,500 2,500 2,500 2,500 2,500 12,500 trainers/ recruitment of students for short courses and training 5.1.17 Advertisement/ assembling, 2,500 2,500 2,500 2,500 2,500 12,500 recruitment of students for MSc and PhD, and training 5.1.18 Facilitation for industry experts / 1,500 1,500 1,500 13,800 13,800 13,800 12,300 58,200 practitioners (10 ppl) 5.1.19 Tuition Fee PhD 30,000 60,000 90,000 60,000 30,000 270,000 5.1.20 Tuition Fee MSc 24,000 48,000 48,000 48,000 24,000 192,000 5.1.21 Traditional Medicine Clinics setup and 20,000 20,000 20,000 20,000 20,000 100,000 maintenance 5.1.22 Stipend PhD (annually) 11,250 11,250 11,250 11,250 90,000 90,000 45,000 405,000 135,00 0 5.1.23 Stipend MSc (annually) 10,000 10,000 10,000 60,000 60,000 60,000 30,000 240,000 5.1.24 Travel (Flights) for Students (return 4,800 4,800 4,800 3,000 - 17,400 flights) 5.1.25 External examiners 1,500 1,500 1,500 1,500 1,500 7,500 5.1.26 Annual dissemination conference and 43,400 43,400 43,400 - 130,200 Annual general meeting 5.1.27 Student presentation at national 1,250 1,250 5,000 5,000 5,000 5,000 22,500 conferences 5.1.28 Student presentation at regional - 3,000 3,000 3,000 3,000 12,000 conferences 5.1.29 Student presentation at international - 4,600 4,600 4,600 4,600 18,400 conferences 5.1.30 Community / Industry attachments 3,450 3,450 13,800 13,800 13,800 6,900 55,200 (Masters) 5.1.31 Community / Industry attachments 3,400 3,400 13,600 20,400 13,600 6,800 61,200 (PhD) 5.1.32 30 Seater Bus 50,000 - - - - 50,000 5.1.33 Bus (fuel and maintenance) 1,800 1,800 1,800 1,800 7,200 7,200 7,200 7,200 36,000 5.1.34 Medical emergency fund / First Aid kit 1,000 1,000 1,000 1,000 1,000 5,000 5.1 Subtotal 373,355 86,410 53,770 28,310 411,800 493,600 410,000 219,400 2,076,645

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Program Development, Approval and Accreditation Plan: A: Steps for new PHARMBIOTRAC Study Programmes development, approval and national accreditation with National Council for Higher Education (NCHE), Uganda:

1 Develop the curriculum for the proposed programmes for accreditation PHARMBIOTRAC Team at PHARMBIOTARC as a unit following guidelines outlined in the Statutory Instruments No.34 (2008) for the Universities and Other Tertiary Institutions (Quality Assurance) Regulations and which is available at the link below: http://www.unche.or.ug/wp-content/uploads/2014/03/Statutory-Instruments-No.342008-the- Universities-and-Other-Tertiary-Insitutions-Quality-Assurance-Regulations-.pdf 2 Present proposed curriculum for the new programmes for approval Faculty Board of Faculty of Medicine, MUST 3 Present proposed curriculum for the new programmes for approval Top Management of MUST 4 Present proposed curriculum for the new programmes for validation MUST internal Quality and approval Assurance Committee 5 Present proposed curriculum for the new programmes for approval MUST Senate 6 Present proposed curriculum for the new programmes for approval MUST Council (Finance and General Purpose Committee) for Council 7 Present proposed curriculum for the new programmes for approval at National Council for Higher national level Education (NCHE)

B: Steps for Accrediting new PHARMBIOTRAC Study Programmes at International Level  As we plan for International Accreditation, communication has been made to the Pharmaceutical Society of Uganda and NCHE in order to help identify international accreditation agencies suitable for the new PHARMBIOTRAC programmes and the steps involved for such accreditation.  We acknowlegde that international accreditation might take longer to archive, nevertheless, the following organizations are earmarked for guidance in the accreditation process; (i) Society for Medicinal Plant and Natural Product Research (GA), Germany www.ga- online.org; (i) Pharmaceutical Biology and Biotechnology, Institute for Pharmaceutical Sciences, University of Freiburg, Germany http://www.plant-sciences.uni-freiburg.de/psf- plant-research-molecular-pharmacognosy.html; (iii) Society of Pharmacognosy, India http://indiansp.com/

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Action Plan: 8.2 Research excellences - student led Timeframe: Year 1, quota 2 to 4 Activity: Establishment of strong research teams and world class facilities for community, laboratory, industrial and clinical research Table 12: Research excellences RESULT High quality skilled graduates, research products and services, publications and patents ACTIVITY 8.2.1 Development of research policy and plan 8.2.2 Purchase and installation of needed major equipment 8.2.3 MSc and PhD research introductory modules teaching. 8.2.4 Electives at BUMETHA for community, industry and partner institutions. 8.2.5 Formation of research teams, presentation of field experiences and development of concepts based on electives findings/experiences 8.2.6 Publication of findings from community, industry and partner institutions in journals 8.2.7 Development of research proposals and protocols/methods in teams 8.2.8 Master/Doctoral committee presentations and evaluation 8.2.9 Research proposal approvals by department, Faculty and Registration of research proposals at National Council for Science and Technology 8.2.10 Research grant awards, purchase of needed reagents/standards 8.2.11 Start of phase 1st lot transdisciplinary research activities for MSc and PhD 8.2.12 MSc and Doctoral presentations and evaluation of research progress 8.2.12 PhDs and MSc manuscript writing and submission for publications OUTPUT 8.2.1 Research policy and plan developed 8.2.2 Needed equipment Purchased and installed 8.2.3 15 MSc 15 and PhD 10students gain research skills 8.2.4 MSc and 10 PhD Students acquire knowledge and experience. 8.2.5 Research teams 5 (2PhD and 3 MSc) formed and field experiences presented and research concepts developed. 8.2.6 Papers 5 published in peer reviewed journals 8.2.7 Research proposals and protocols/methods 25 developed by teams 8.2.8 Master/Doctoral proposals 25 presented and evaluated 8.2.9 Research proposals 25 approved by department, Faculty and Registered with National Council for Science and Technology 8.2.10 Research grants 25 awarded and needed reagents/standards purchased 8.2.11 Phase 1 transdisciplinary research activities for MSc and PhD 5 teams started 8.2.12 MSc and Doctoral 25research presented and evaluated 8.2.13 PhDs and MSc students 25 manuscript written and submitted for publication OUTPUT INDICATOR SOURCE OF VERIFICATION 8.2.1 Research policy and plan document 8.2.1 Records 8.2.2 Equipment available and in usage 8.2.2 Laboratories and records 8.2.3 MSc and PhD applying research skills 8.2.3 Laboratories data records 8.2.4 Students applying knowledge and experience 8.2.4 Reports in Centre records gained from placements. 8.2.5 Centre records 8.2.5 Research teams functioning and concepts 8.2.6 University and journal websites submitted to graduate school. online 8.2.6 Papers published in peer reviewed journals or 8.2.7 Laboratory data records journal acknowledgement available online 8.2.8 Centre and Graduate school records

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8.2.7 Research proposals and protocols/methods 8.2.9 Centre and Graduate school records availed and in usage 8.2.10 Centre and laboratory records 8.2.8 Master/Doctoral proposals presentations and 8.2.11 Centre Exhibition unit evaluation minutes 8.2.12 Centre and Graduate school records 8.2.9 Research proposals approval letters from 8.2.13 Centre and Graduate school records department, Faculty and Registered with National Council for Science and Technology 8.2.10 Research grant awarding minutes and reagents/standards available and in usage 8.2.11 Research teams and research data or products /patents for MSc and PhD 8.2.12 MSc and Doctoral research and seminars minutes 8.2.13 MSc and Doctoral research presentation and evaluation minutes IMPLEMENTATION 8.2.1 Research policy and plan document by 31/8/2016 MILESTONES 8.2.2-8.2.4 Students placed in communities, industry and partner’s institutions by 1/1/2017 8.2.5-8.2.10 Formation of research teams and award of grants functioning by 1/3/2017 8.2.11-8.2.13 Research data or products /patents/publications produced by MSc and PhD students by 31/8/2017. PROCUREMENT RESPONSIBILITY FOR Internal IMPLEMENTATION Dr. Casim Umba Tolo, Centre Leader, research supervisor and mentor biological Dr. Patrik Engeu Ogwang, Deputy Centre Leader, research supervisor and mentor - Biopharmaceuticals Dr. Esther Atukunda, Research supervisor and mentor - Clinical trials Assoc Prof. Juliet Mwanga, Chair Research, research supervisor and mentor Prof. Celestine Obua, research supervisor and mentor Prof. Amon Agaba, research supervisor and mentor Dr. Joel Bazira, Medical microbiology Prof Damarias Lafita, Prof. Nosmo Mukiibi Prof. Gertrude Kiwanuka Nakiwala Assoc Prof. Edgar Mulogo Dr. Eunice Olet Dr. Grace Birungi, Anlytical Chemistry National Academic Partners: Prof. Maud Kamatenesi, Ethnobotanist, Bishop Stuart University Prof. Hannington Oryem Origa, Plant Physiologist, Makarere Univesity Kampala International Academic Partners Dr. Ashwini Godbole Ayurvedia and neurodegenerative disoders, Trans- Disciplinary University, India Dr. Vijayalakshmi Babu, Ayurvedia and pharmbiotechnolgy, Trans-

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Disciplinary University, India Prof. Pamela Weather, Plant Biologist and biotechnologist, Worcester Polytechnic Institute, USA Prof. Kamal Rashid, Biomanufacturing and Education, Worcester Polytechnic Institute, USA Prof. Roy Hegedus Bioprocess Lab, Worcester Polytechnic Institute, USA Prof. Susan Roberts has expressed interest cell cultures for cancer drugs, Worcester Polytechnic Institute, USA DURATION: 12 months Commencement: 01/01/2017 Completion: 31/08/2017

PRIMARY CONSTITUENTS: PARTICIPANTS: communities, Industry staff, patients, Students, laboratory staff, faculty, herbalists, Traditional Healers partner institutions, NCRI, NDA, NEMA, UNCST, THETA, BUMETHA, ASSUMPTIONS 1. Project approved by May 2016 2. Memorandum of Understanding (MoUs ) with partners signed by May 2016 3. National and Regional stability 4. Revised and new Curricula accreditation expedited 5. Timely disbursement of funds FINANCIAL IMPLICATIONS 1,807,039USD Budget Line Analysis First Year Y Y Y Y Tota Q1 Q2 Q3 Q4 2 3 4 5 l 5.2.1 Research Policy and Plan draft 4,620 - 1,980 - - 6,600 development (Y1 development Y4 review) 5.2.2 Research Policy and Plan 17,650 - 17,650 - - 35,300 finalisation (Y1 development Y4 review) 5.2.3 Staff attachments to foreign 7,775 7,775 7,775 - - 23,325 laboratories WPI (USA) 5.2.4 Staff attachments to foreign 5,550 5,550 5,550 - - 16,650 laboratories IHST (India) 5.2.5 Staff attachments to foreign 15,600 15,600 15,600 - - 46,800 laboratories KEMRI (Kenya) 5.2.6 Staff attachments to foreign 16,050 16,050 16,050 - - 48,150 laboratories Gezira (Sudan) 5.2.7 Establishment of Living gene 10,400 5,200 5,200 5,200 - - - - 26,000 bank (Garden) - MUST 5.2.8 Staff research funds 3,000 3,000 6,000 3,000 20,000 15,000 15,000 - 65,000 5.2.9 Staff participation in regional 2,910 2,910 5,820 2,910 14,550 14,550 14,550 14,550 72,750 conference 5.2.10 Staff participation in international 3,520 3,520 7,040 3,520 17,600 17,600 17,600 17,600 88,000 conference 5.2.11 Germplasm collection missions 5,500 5,500 11,000 11,000 11,000 11,000 55,000 (MUST) 5.2.12 Pharm-Biotech laboratory 94,500 945 945 945 945 98,280 equipment purchase, installation, tear and wear 5.2.13 Product development laboratory, 1,886 1,886 1,886 1,886 purchase, installation, tear and 188,600 196,144 wear 5.2.14 Analytical Laboratory, purchase, 1,185 1,185 1,185 1,185 installation, tear and wear 118,500 123,240 5.2.15 Journal Publication fee (Open 12,500 15,000 15,000 15,000 17,500 75,000 Access) 5.2.16 Patenting Fees - 5,000 5,000 5,000 15,000 5.2.17 Monographs (Product 3,000 3,000 6,000 6,000 6,000 6,000 30,000 Monographs) 5.2.18 Masters Seminars 930 930 1,860 1,860 1,860 1,860 9,300

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5.2.19 Doctoral Seminars 930 930 1,860 1,860 1,860 1,860 9,300 5.2.20 Supervision fee (Masters) 750 750 750 750 3,000 5.2.21 Supervision fee (PhD) - 1,000 1,000 1,000 3,000 5.2.22 Supervision fee field (Masters) (3 1,500 1,500 6,000 6,000 6,000 3,000 24,000 days / semester) 5.2.23 Supervision fee fee (PhD) (3 1,000 1,000 4,000 4,000 4,000 2,000 16,000 days/ semester) 5.2.24 Joint follow up proposal 7,450 - 7,450 - 14,900 development 5.2.25 Chair Research Excellence 220 110 220 110 660 660 660 660 3,300 coordination 5.2.26 Research support for MSc 21,000 21,000 21,000 21,000 - 84,000 students 5.2.27 Research support for PhD 45,000 90,000 90,000 45,000 students 135,000 405,000 5.2.28 Station wagon purchase (4 wheel - - - - drive) 100,000 100,000 5.2.29 Fuel and maintenance for Station 4,200 4,200 4,200 4,200 16,800 16,800 16,800 16,800 84,000 wagon (4 wheel drive) 5.2.30 Laboratory technician 1,500 1,500 1,500 1,500 6,000 6,000 6,000 6,000 30,000 5.2 Subtotal 527,350 78,990 91,385 71,950 289,521 347,701 245,546 154,596 1,807,039

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Action Plan 8.3 Quality Assurance Timeframe: Q1 Y1 to Q4 Activity: Achieving quality assurance at the centre Table 13: Quality Assurance SUB ACTIVITY 8.3.1 Conducting regular Internal Audits and reports using defined or TASK checklists 8.3.2 Setting up computerised centralised data archive for reports linked to CEMAS 8.3.3 Hiring of consultant for quarterly M&E 8.3.4 Inviting audit by professional bodies (annually) 8.3.5 Inviting audit by National Council of Higher Education 8.3.6 Certification for laboratory and management systems 8.3.7 Conducting funder audits (annually) RESULT: High quality graduates/High quality research outputs/ Improved University DLI/DLR 2.4 ranking OUTPUT 8.3.1 Regular Internal Audits reports 8.3.2 Computerised centralised data archive for reports linked to CEMAS 8.3.3 Quarterly M&E reports 8.3.4 Professional bodies audit reports 8.3.5 National Council of Higher Education audit reports 8.3.6 Certified laboratories and management systems 8.3.7 Annual funder audits reports OUTPUT INDICATOR SOURCE OF VERIFICATION 8.3.1 Number of Internal Audits reports 8.3.1 University and centre records 8.3.2 Number Computerised centralised data 8.3.2 CEMAS online archives linked to CEMAS 8.3.3 Graduate school and centre 8.3.3 Number of external Quarterly M&E reports records 8.3.4 Number of professional bodies audit reports 8.3.4 Graduate school and centre 8.3.5 Number of National Council of Higher records Education audit reports 8.3.5 Graduate school and centre 8.3.6 Number of Certified laboratories and records management systems 8.3.6 Center records 8.3.7 Number of annual funder audits reports 8.3.7 University and centre grant records IMPLEMENTATION 8.3.1 Conducting regular Internal Audits and reports using MILESTONES defined checklists Q 4 Y1 8.3.2 Setting up computerised centralised data archive for reports linked to CEMAS Q1 Y1 8.3.3 Hiring of consultant for quarterly M&E Q2 Y1 8.3.4 Inviting audit by professional bodies (annually) Q2 Y1 8.3.5 Inviting audit by National Council of Higher Education Q2 Y1 8.3.6 Certification for laboratory and management systems Q4 Y1

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8.3.7 Conducting funder audits (annually) by Q4 Y1 PROCUREMENT Computers/ External M&E consultant RESPONSIBILITY FOR Centre leader, Chair quality assurance and quality control, IMPLEMENTATION Project Administrator, IT department, support from partners and HODs DURATION: 12 months Start: Q1 Y1 DURATION: 12 months PRIMARY CONSTITUENTS: PARTICIPANTS: CEFTER Team, students and partners University staff, partner staff ASSUMPTIONS MoUs with partners signed, students recruited, learning started in time FINANCIAL IMPLICATIONS 38,000USD First Year Y Y Y Y Budget Line Analysis Total Q1 Q2 Q3 Q4 2 3 4 5 5.3.1 Quality Assurance and M&E 2,000 2,000 2,000 4,000 4,000 4,000 4,000 20,000 consultancy 5.3.2 Chair Learning and Research 220 110 220 110 660 660 660 660 3,300 Quality Assurance 5.3.3 Tracer studies 3,000 3,000 3,000 3,000 3,000 15,000 5.3 Subtotal 220 2,110 2,220 5,110 7,660 7,660 7,660 7,660 38,300

Achieving quality assurance at the PHARMBIOTRAC

A dedicated chair for Quality Assurance and Quality Control supported by a team is in place (see project Organizational Chart, page 30), which forms part of the project day to day activities to assess and give timely feedback (internal audits) to the learning and research units of the PHARMBIOTRAC for continuous stimulation of innovation in learning and research by the students and faculty. This will help build-in and monitor quality in learning and research of students and faculty working at PHARMBIOTRAC. Further still, this concept is well captured in the implementation plan through activities including; conducting benchmarking activities at regional and international centres of learning and research from the start of the PHARMBIOTRAC, identifying and attracting talented students and faculty to PHARMBIOTRAC, provision of adequate and state of the art learning and research facilities including e-learning facilities linked to regional and international partners, regular higher degree/doctoral committee meetings at PHARMBIOTRAC to assess students’ and faculty research progress throughout the program, continuous assessments of the students involving a pool of external examiners, placement of students and faculty in relevant industries/ research centres and other laboratories at national and regional levels for at least a month, selection of best performing students for placement in international laboratories for skills development and mentoring, holding innovation incubation events and platforms at national, regional and international level.

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Action Plan 8.4 Equity Dimension

Timeframe: Q1 Y1 to Q4 Activity: Achieving equity at the centre Table 14: Equity Dimension SUB 8.4.1 Conducting access audit for Institute ACTIVITY or 8.4.2 Developing inclusive staff and student recruitment guidelines Open and TASK widely distributed (outreach and channels) 8.4.3 Developing all-inclusive application procedure displayed online, offline and assisted application and selection procedure 8.4.4 Conducting work place adjustment 8.4.5 Setting day infant care room for breast feeding and nappy changing 8.4.6 Expanding existing community centred education modules 8.4.7 Placing student in rural communities 8.4.8 Utilising Rural and urban located training centres 8.4.9 Utilising regional located training centres RESULT: Female students and faculty attracted/Rural student attachments/ DLI/DLR 2.4 Quality of life and productivity of communities enhanced OUTPUT 8.4.1 Access audit for Institute done and report 8.4.2 An inclusive staff and student recruitment guidelines manual openly and widely distributed (outreach and channels) 8.4.3 An inclusive application procedure displayed online, offline and assisted application and selection procedure in place 8.4.4 Work place adjusted and report 8.4.5 Day infant care room for breast feeding and nappy changing in place 8.4.6 Expanded community centred education modules developed 8.4.7 Students placed in rural communities and reports 8.4.8 Rural and urban located training centres utilised 8.4.9 Regional located training centres utilised OUTPUT INDICATOR SOURCE OF VERIFICATION 8.4.1 Number Access audit for Institute report 8.4.1 Centre records 8.4.2 Number of an inclusive staff and student recruitment 8.4.2 CEMAS guidelines open and widely distributed (outreach and 8.4.3 CEMAS channels) manual 8.4.4 Centre and University 8.4.3 Number of an inclusive application procedure displayed estates dept records online, offline and assisted application and selection 8.4.5 Centre and University procedure estates dept records 8.4.4 Number of Work place adjusted and report 8.4.6 Centre records 8.4.5 Number of day infant care room for breast feeding and 8.4.7 Centre and graduate nappy changing established school records 8.4.6 Number Expanded community centred education modules 8.4.8 Centre and graduate developed school records 8.4.7 Number of Students placed in rural communities 8.4.9 Centre and graduate 8.4.8 Number of Rural and urban located training centres school records utilised 8.4.9 Number of regional located training centres utilised IMPLEMENTATION 8.4.1 Access audit for Institute done and report Q2 Y1 MILESTONES 8.4.2 An inclusive staff and student recruitment guidelines manual openly and widely distributed (outreach and channels) Q2 Y1 8.4.3 An inclusive application procedure displayed online, offline

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and assisted application and selection procedure in place Q2 Y1 8.4.4 Work place adjusted and report Q2 Y1 8.4.5 Day infant care room for breast feeding and nappy changing in place Q2 Y1 8.4.6 Expanded community centred education modules developed Q2 Y1 8.4.7 Students placed in rural communities and reports Q3 Y1 8.4.8 Rural and urban located training centres utilised 8.4.9 Regional located training centres utilised Q4 Y1 PROCUREMENT Upgrading materials, consultant RESPONSIBILITY FOR Centre leader, Chair quality assurance and quality control, Project IMPLEMENTATION Administrator, IT department, support from partners and HODs DURATION: 12 months Start: Q1 Y1 DURATION: 12 months PRIMARY CONSTITUENTS: PARTICIPANTS: CEFTER Team, University Estates department University staff, partner staff ASSUMPTIONS MoUs with partners signed, students recruited, learning started in time FINANCIAL IMPLICATIONS 10,000USD First Year Y Y Y Y Budget Line Analysis Total Q1 Q2 Q3 Q4 2 3 4 5 5.4.1 Access audit 2,000 - - 2,000 - 4,000 5.4.2 Facility upgrade 4,000 - - 2,000 - 6,000 5.4 Subtotal 6,000 - - - - - 4,000 - 10,000

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Action Plan 8.5. Attracting regional students and academic staff Timeframe: Q1 Y1 to Q1 Y5 Activity 1.6 Facilitate student enrolments and academic staff recruitment to the centre Table 15: Attracting regional students and academic staff SUB ACTIVITY or 8.5.1 Development and widely disseminate an attractive research and TASK innovation policy 8.5.2 Establish expert data base at the centre 8.5.3 Carry out Education and career fairs 8.5.4 Provide Language support RESULT:  High quality students and faculty at the centre DLI/DLR 2.4 OUTPUT 8.5.1-8.5.2 Regional Faculty attracted (1) 8.5.1-8.5.3 Regional Students attracted (7) 8.5.1 Expert database established and utilised (1) 8.5.2 Education and career fairs conducted (1) 8.5.3 Language support provided (3) OUTPUT INDICATOR SOURCE OF VERIFICATION 8.5.1 Number of regional faculty attracted 8.5.1 Graduate school Records/center 8.5.2 Number of regional students attracted. website 8.5.3 Number of Education and career fairs 8.5.2 Computerised Education and conducted Management Accounting System 8.5.4 Number of students benefitting from 8.5.3 Staff records Language support 8.5.4 Exhibition reports IMPLEMENTATION 8.5.1 Regional faculty attracted by 31/8/2016 MILESTONES 8.5.2 Regional students attracted by 31/1/2017 8.5.3 Education and career fairs conducted 31/1/2017 8.5.4 Students benefitting from Language support 31/1/2017 PROCUREMENT N/A RESPONSIBILITY FOR Centre leader IMPLEMENTATION Deputy centre leader Chair Innovation & Entrepreneurship Project administrator Project administrative assistant DURATION: 12 months 01/Oct/2016 DURATION: 12 months PRIMARY CONSTITUENTS: PARTICIPANTS: Universities students and Centre leadership and staff, partner academics, parent, sponsors, organisation/ universities, RUFORUM employers ASSUMPTIONS Information is shared widely and students and faculty willing to come to Uganda FINANCIAL IMPLICATIONS 260,000USD Budget Line Analysis First Year Y Y Y Y Total Q1 Q2 Q3 Q4 2 3 4 5

5.5.1 Dissemination of Research Policy to 1,000 1,000 1,000 1,000 1,000 5,000 attract academic staff of the region 5.5.2 Language learning support 750 750 750 750 3,000 3,000 3,000 3,000 15,000 5.5.3 Recruited staff salaries (2 senior 12,000 12,000 12,000 12,000 48,000 48,000 48,000 48,000 240,000 lecturers) 5.5 Subtotal 12,750 12,750 13,750 12,750 52,000 52,000 52,000 52,000 260,000

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Action Plan 8.6 Regional and national academic partners Timeframe: Y1 Q1-4 Activity 1.6 Promoting collaboration with regional and national academic partners Table 16: Regional and national academic partners SUB ACTIVITY 8.6.1 Training staff of Bishop Stuart University and Gulu University at MSc or TASK and PhD to enhance their capacity for teaching ethno botany and pharmacy respectively 8.6.2 Establishing living gene banks and herbarium in Gulu university and Bishop Stuart University research 8.6.3 Inviting regional and national faculty delivering block lecturers at the centre 8.6.4 Provision of Pick up vehicles for GU and BSU 8.6.5 Conducting joint research projects and publications RESULT: Improved with national and regional academic partners DLI/DLR 2.4 OUTPUT 8.6.1 Staff of Bishop Stuart University and Gulu University trained at MSc and PhD (2) 8.6.2 Living gene banks established at GU and BSU 8.6.3 Regional and national faculty delivered block lecturers at the centre (8) 8.6.4 Pick up vehicles delivered to GU and BSU (2) 8.6.5 Joint research projects and publications conducted (2) OUTPUT INDICATOR SOURCE OF VERIFICATION 8.6.1 Number of Staff of Bishop Stuart University and 8.6.1 Admission records Gulu University trained 8.6.2 Living gene bank reports 8.6.2 Number of Living gene banks established at GU 8.6.3 Records of visiting faculty at and BSU the 8.6.3 Number of delivered block lecturers at the centre centre delivered by regional and national partners 8.6.4 Vehicle 8.6.4 Number of Pick up vehicles delivered to GU and logbooks/procurements BSU records 8.6.5 Number of Joint research projects and 8.6.5 Project records and publications conducted publications IMPLEMENTATION MoUs signed with partners by 01/Oct/2016 MILESTONES PROCUREMENT Travel tickets RESPONSIBILITY FOR Centre leader, deputy centre leader, Project administrator, IMPLEMENTATION department heads and staff at partner universities DURATION: 12 months Start date: Y1 Q1 Completion: Q4 PRIMARY CONSTITUENTS: Centre, university, PARTICIPANTS: Staff at partner universities, partner universities, centre students university students, families of students ASSUMPTIONS MoUs signed with partners FINANCIAL IMPLICATIONS 489,500USD First Year Total Budget Line Analysis Y 2 Y 3 Y 4 Y 5 Q1 Q2 Q3 Q4 USD 5.6.1 Regional Visiting faculty members - 7,410 7,410 7,410 7,410 7,410 37,050 Kenya 5.6.2 Regional Visiting faculty members - 7,410 7,410 7,410 7,410 7,410 37,050 South Africa 5.6.3 Regional Visiting faculty members - 7,410 7,410 7,410 7,410 7,410 37,050

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Sudan 5.6.4 Regional Visiting faculty members - 7,410 7,410 7,410 7,410 7,410 37,050 Mozambique 5.6.5 National Visiting faculty members - 2,960 2,960 2,960 2,960 2,960 14,800 BSU 5.6.6 National Visiting faculty members - 3,260 3,260 3,260 3,260 3,260 16,300 Makerere 5.6.7 National Visiting faculty members - 3,260 3,260 3,260 3,260 3,260 16,300 UTAMU 5.6.8 National Visiting faculty members - 3,460 3,460 3,460 3,460 3,460 17,300 Gulu University 5.6.9 Student attachment African Partner - 19,000 23,750 23,750 23,750 9,500 99,750 KEMRI - Kenya 5.6.10 Student attachment African Partner - 21,000 26,250 26,250 26,250 10,500 110,250 Gezira University - Sudan 5.6.11 Establishment of Living gene bank 26,000 - - - - 26,000 (Garden) - BSU/GU 5.6.12 Germplasm collection maintenance 4,060 4,060 4,060 4,060 4,060 20,300 (BSU) 5.6.13 Germplasm collection maintenance 4,060 4,060 4,060 4,060 4,060 20,300 (Gulu University) 5.6 Subtotal 34,120 - 50,710 31,870 100,700 100,700 100,700 70,700 489,500

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Action Plan 8.7 Regional and national sector partners including the private sector Timeframe: Q1 Y1 to Q1 Y5 Activity 1.6 Promoting industry exposure of students and staff, and joint projects Table 17: Regional and national sector partners including the private SUB 8.7.1 Conducting joint research projects and develop products and services ACTIVITY 8.7.2 Training of herbalists or TASK 8.7.3 Training of industry staff 8.7.4 Placing students at the sector partners’ institutions 8.7.5 Inviting industry experts to give block lectures 8.7.6 Offering scholarships at MSc and PhD for sector staff 8.7.7 Purchasing and installing needed equipment at sector partners RESULT: Improved productivity and quality of products and services produced by sector partners OUTPUT 8.7.1 joint research and products and services jointly developed (2) 8.7.2 Herbalists trained (1000) 8.7.3 Industry staff trained (100) 8.7.4 students placed at sector industry (25) 8.7.5 Industry expects invited to give lectures (10) 8.7.6 MSc (5) and (2) PhD scholarships awarded to sector staff 8.7.7 Pilot production Equipment purchased and installed at sector unit (3). OUTPUT INDICATOR SOURCE OF 8.7.1 Number of joint research and products and services jointly VERIFICATION development 8.7.1-8.7.7 Centre 8.7.2 Number of Herbalists trained records and 8.7.3 Number of Industry staff trained attendance lists 8.7.4 Number of students placed at sector industry 8.7.5 Number of Industry expects invited to give lectures 8.7.6 Number of MSc and PhD scholarships awarded to sector staff 8.7.7 Number of Pilot production Equipment purchased and installed at sector unit. IMPLEMENTATION MoUs signed by 31/5/2016 MILESTONES PROCUREMENT Equipment for some sector partners RESPONSIBILITY FOR Centre leader, Project administrator, support from partners and IMPLEMENTATION HODs DURATION: 60 months Start date: Q2 Y1 Completion: Q2 Y1 PRIMARY CONSTITUENTS: PARTICIPANTS: Center Team, centre students, partner staff Private sector workers, communities. ASSUMPTIONS MOUs signed with partners FINANCIAL IMPLICATIONS 89,500USD First Year Total Budget Line Analysis Y 2 Y 3 Y 4 Y 5 Q1 Q2 Q3 Q4 USD 5.7.1 Community training kits 2,100 2,100 2,100 6,300 6,300 6,300 6,300 31,500 5.7.2 Training Centre (Traditional Medical 10,000 400 400 400 400 11,600 Practitioners) BUMETHA 5.7.3 Training Centre (Traditional Medical 10,000 400 400 400 400 11,600 Practitioners) IIACM 5.7.4 Training Centre (Traditional Medical 10,000 400 400 400 400 11,600 Practitioners) THETA-Uganda 5.7.5 Training Centre (Traditional Medical 10,000 400 400 400 400 11,600 Practitioners) ANAMED

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5.7.6 Training Centre (Traditional Medical 10,000 400 400 400 400 11,600 Practitioners) NCRL centre 5.7. Subtotal - 2,100 2,100 52,100 8,300 8,300 8,300 8,300 89,500

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Action Plan 8. 8 International academic partners Timeframe: Y1Q 2-Q4 Activity 1.8 Facilitating knowledge and technology transfer to the centre Table 18: 8 International academic partners SUB 8.8.1 Inviting faculty to teach and mentor staff ACTIVITY or 8.8.2 Implementation of Joint Research projects TASK 8.8.3 Joint publication/patenting of results 8.8.4 Sharing or transfer of technologies 8.8.5 Placement of best student and staff at partner laboratories RESULT: Improved quality of learning and research at centre OUTPUT 8.8.1 International faculty invited (2) 8.8.2 joint research projects implemented (1) 8.8.3 Joint publications/patent (2) 8.8.4 Technology transferred (2) 8.8.5 Best student placements (2) OUTPUT INDICATOR SOURCE OF VERIFICATION 8.8.1 Number of international staff invited 8.8.1 Centre and graduate school records 8.8.2 Number of joint research projects and reports conducted 8.8.2 Centre records 8.8.3 Number of Joint publications/patents 8.8.3 Copies of publications/patent online 8.8.4 Number of Technologies transferred 8.8.4 Record and usage at recipient unit 8.8.5 Number of best student sent to partner labs 8.8.5 Graduate school and centre/student reports IMPLEMENTATION 8.8.1 International faculty invited by 31/5/2017 MILESTONES 8.8.2 joint research projects implemented 31/5/2017 8.8.3 Joint publications/patent 31/5/2017 8.8.4 Technology transferred 31/5/2017 8.8.5 Best student placements 31/5/2017 PROCUREMENT N/A RESPONSIBILITY FOR Centre leader, Project Manager, support from partners and HODs IMPLEMENTATION DURATION: 6 months Start date: Q3 Y1 Completion: Q4 Y1 PRIMARY CONSTITUENTS: PARTICIPANTS: CEFTER Team, Board Partners, students faculty ASSUMPTIONS MoUs signed with partners FINANCIAL IMPLICATIONS 146,800USD First Year Total Budget Line Analysis Y 2 Y 3 Y 4 Y 5 Q1 Q2 Q3 Q4 USD 5.8.1 International Visiting faculty members 9,090 9,090 9,090 9,090 9,090 45,450 (USA) 5.8.2 International Visiting faculty members 7,490 7,490 7,490 7,490 7,490 37,450 (India) 5.8.3 Sabbatical Place (6 months per year) 10,650 10,650 21,300 21,300 - - 63,900 5.8 Subtotal - - 27,230 10,650 37,880 37,880 16,580 16,580 146,800

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Action Plan 8.9 Management and governance Timeframe: Y1 Q1-Q4 Activity: Improving management and governance at PHARMBIOTRAC and the University Table19: Management and governance SUB 8.9.1 Reviewing existing Human resources manual ACTIVITY or 8.9.2 Conducting project Staff appraisals by peers and students TASK 8.9.3 Reviewing audit reports and taking actions recommended 8.9.4 Participating at Council and senate meetings 8.9.5 Conducting management Meetings of Centre Steering committee 8.9.6 Conducting management Meeting of Centre Executive committee 8.9.7 Developing and using Centre Operation manual 8.9.8 Developing and using Grants operation manual 8.9.9 Procuring centre computers and accounting packages 8.9.10 Computerising centre Financial Management and accounting information system (QuickBooks) RESULT:  Overall Improvement in university management and governance OUTPUT 8.9.1 Secretariat established (1) 8.9.2 Human resources manual reviewed (1) 8.9.3 Secretariat staff (3) 8.9.4 Project Staff appraised by peers and students done (2 times) 8.9.5 Audit reports reviewed and action implementation oversight as needed (4 times) 8.9.6 Participated in all Council and senate meetings (2 times) 8.9.7 Centre Steering committee meetings held (4 times) 8.9.8 Centre Executive committee meetings held (12 times) 8.9.9 Centre Operation manual developed and used (1) 8.9.10 Centre Grants operation manual developed and used (1) 8.9.11 Centre computers and accounting packages purchased, installed and used (6 sets) 8.9.12 Centre Management and accounting information system computerised and linked to CEMAS (1 set) OUTPUT INDICATOR SOURCE OF VERIFICATION 8.9.1 Number of Existing Human resources manual 8.9.1 Human resource reviewed office/centre 8.9.2 Number of Project Staff appraised by peers and 8.9.2 Staff appraisal reports at students centre 8.9.3 Number of audit reports reviewed and actions taken 8.9.3 Report of actions from audit 8.9.4 Number of Participation at all Council and senate review meetings 8.9.4 Minutes of Council and 8.9.5 Number of Centre Steering committee meetings held senate meetings 8.9.6 Number of Centre Executive committee meetings held 8.9.5 Minutes of Centre Steering 8.9.7 Number of Centre Operation manual developed and committee meetings used 8.9.6 Minutes of Centre Executive 8.9.8 Number of Centre Grants operation manual developed committee meetings and used 8.9.7 Copy of Operation manual 8.9.9 Number of centre computers and accounting packages 8.9.8 Copy of Grants operation purchased, installed and used manual 8.9.10 Number of centre Management and accounting 8.9.9 Centre computers information system computerised and linked to 8.9.10 Centres computers system CEMAS

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IMPLEMENTATION Secretariat established by 31/5/2016 MILESTONES PROCUREMENT Computers, furniture and staff recruitment RESPONSIBILITY FOR Centre leaders, Project Administrator IMPLEMENTATION DURATION: 60 months Q1 Y1 Completion: Y1 Q4 PRIMARY CONSTITUENTS: PARTICIPANTS: University academic Centre staff, students staff, students ASSUMPTIONS Time procurement of secretariat facilities FINANCIAL IMPLICATIONS 734,926USD First Year Y Y Y Y Total Budget Line Analysis Q1 Q2 Q3 Q4 2 3 4 5 USD 5.9.1 Establishment of PHARMBIOTRAC 23,000 23,000 secretariat 5.9.2 Installation of ICT systems for finance 5,000 5,000 & administration 5.9.3 Inception and planning meeting of all 35,736 35,736 partners 5.9.4 Meeting of Steering Committee 4,530 4,530 9,060 9,060 9,060 9,060 45,300 5.9.5 Meeting of Executive Committee 380 190 380 190 1,140 1,140 1,140 1,140 5,700 5.9.6 Meeting of Finance & Administration 120 120 120 120 480 480 480 480 2,400 committee 5.9.7 Core Team Project review and 1,850 1,850 1,850 1,850 5,550 5,550 5,550 5,550 27,750 planning meeting 5.9.8 PHARMBIOTRAC meetings with WB 980 980 980 980 3,920 3,920 3,920 3,920 19,600 & IUCEA 5.9.9 Bi-Annual Meeting by IUCEA 12,020 12,020 12,020 12,020 24,040 24,040 24,040 24,040 120,200 5.9.10 Staff orientation workshop 1,000 - - - - 1,000 5.9.11 PHARMBIOTRAC Administrator 6,000 6,000 6,000 6,000 24,000 24,000 24,000 24,000 120,000 5.9.12 PHARMBIOTRAC Administrative 1,500 1,500 1,500 1,500 6,000 6,000 6,000 6,000 30,000 Assistant 5.9.13 PHARMBIOTRAC Accountant 6,000 6,000 6,000 6,000 24,000 24,000 24,000 24,000 120,000 5.9.14 PHARMBIOTRAC Procurement 1,500 1,500 1,500 1,500 6,000 6,000 6,000 6,000 30,000 Assistant / Secretary 5.9.15 Partner coordination / supervision 5,960 5,960 5,960 23,840 23,840 23,840 23,840 113,240 visits regional (2 ppl) 5.9.16 Driver 750 750 750 750 3,000 3,000 3,000 3,000 15,000 5.9.17 Cleaner 600 600 600 600 2,400 2,400 2,400 2,400 12,000 5.9.18 Office supplies 450 450 450 450 1,800 1,800 1,800 1,800 9,000 5.9 Subtotal 101,416 37,920 42,640 37,920 135,230 135,230 135,230 135,230 734,926

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Action Plan 8.10 Sustainable financing Timeframe: Y1 Q2 to Y1 Q4 Activity: Achieving sustainability of the centre Table 20: Sustainable financing SUB 8.10.1 Attracting Research grants through proposal writing ACTIVITY or 8.10.2 Charging fees TASK 8.10.3 Charging Bench fees 8.10.4 Offering consultancies at fee 8.10.5 Offering laboratory tests at fee 8.10.6 Contract manufacturing 8.10.7 Contract research 8.10.8 Sale of products 8.10.9 Attaining Royalties from patents and benefit sharing agreements 8.10.10 Attracting Endowments 8.10.11 Organising fundraising drives RESULT: Productive and sustainable Centre OUTPUT 8.10.1 Research grants through proposal writing (1) 8.10.2 Fees charges on (1000) herbalists and (100) in-service clients 8.10.3 Bench fees collected from (10) clients 8.10.4 Consultancies at fee (2) clients 8.10.5 Laboratory tests fee collected from (10) clients 8.10.6 Contract manufacturing for (5) clients 8.10.7 Contract research for (1) client 8.10.8 Sale of products to public (2) product types sold 8.10.9 Royalties from patents and benefit sharing agreements (0) 8.10.10 Attracting Endowments (0) 8.10.11 Fundraising drives organised (1) OUTPUT INDICATOR SOURCE OF 8.10.1 Number of Research grants attracted through proposal writing VERIFICATION 8.10.2 Amount of fees collected from herbalists and in-service clients 8.10.3 Amount of bench fees collected from clients Secretariat records 8.10.4 Amount collected from consultancy fees 8.10.5 Amount collected from laboratory tests fee 8.10.6 Amount collect from contract manufacturing for clients 8.10.7 Amount collected from contract research for clients 8.10.8 Amount collected from sale of products to public 8.10.9 Amount collect from royalties and benefit sharing agreements 8.10.10 Amount collect from attracting Endowments 8.10.11 Amount collected from fundraising drives organised IMPLEMENTATION Training started by 31/8/2016 MILESTONES PROCUREMENT Training manuals and handouts RESPONSIBILITY FOR Centre leader, Chair Innovation and Business Management, IMPLEMENTATION Project Manager, support from partners and HODs DURATION: 12 Starting: Q1 Y1 DURATION: 12 PRIMARY CONSTITUENTS: PARTICIPANTS: Centre team, students, and staff Partner institutions, communities, organisations ASSUMPTIONS Clients willing to pay for services at the center FINANCIAL IMPLICATIONS 311,020USD Budget Line Analysis First Year Y 2 Y 3 Y 4 Y 5 Total

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Q1 Q2 Q3 Q4 USD 5.10.1 Chair Innovation & Business 7,500 7,500 7,500 7,500 30,000 30,000 30,000 30,000 150,000 Management 5.10.2 Business clinic (furniture, computer, 8,800 880 880 880 880 12,320 software) 5.10.3 Product exhibitions (Regional) 5,200 5,200 5,200 5,200 5,200 26,000 5.10.4 Product exhibitions (National) 2,280 2,280 2,280 2,280 2,280 11,400 5.10.5 Chair innovation & Business 220 110 220 110 660 660 660 660 3,300 Management Meetings 5.10.6 Student handbooks (in-service 1,000 1,000 1,000 1,000 1,000 5,000 professionals short course) 5.10.7 Student handbooks (short course for 5,000 5,000 5,000 5,000 5,000 25,000 TMPs) 5.10.8 Business clinic coordination & 3,900 3,900 3,900 3,900 15,600 15,600 15,600 15,600 78,000 branding 5.10 Subtotal 26,420 11,510 19,100 11,510 60,620 60,620 60,620 60,620 311,020

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Action Plan 8.11 Monitoring and Evaluation System Timeframe: Y1 Q2 to Q4 Activity: Conducting regular and monitoring project and evaluation Table 21: Monitoring and Evaluation System SUB 8.11.1 Developing centre strategic plan ACTIVITY 8.11.2 Developing centre M&E strategy with plan or TASK 8.11.3 Conducting centre M&E committee meetings 8.11.4 Conducting centre Regular M&E exercises & reporting 8.11.5 Conducting M&E Studies / field missions to partner institutions using DLIs 8.11.6 Conducting Employer tracer studies 8.11.7 Conducting Alumnae tracer studies RESULT: Effective systems at the centre OUTPUT 8.11.1 Centre strategic plan developed and used (1) 8.11.2 Centre M&E strategy developed and followed (1) 8.11.3 Centre M&E committee meetings conducted (4) 8.11.4 Centre M&E exercises & reporting conducted (4) 8.11.5 M&E Studies / field missions to partner institutions using DLIs conducted (1) 8.11.6 Employer tracer studies conducted (1) 8.11.7 Alumnae tracer studies conducted (1) OUTPUT 8.11.1 Number of centre strategic plan developed and used INDICATOR 8.11.2 Number of Centre M&E strategy developed and followed 8.11.3 Number of centre M&E committee meetings conducted 8.11.4 Number of centre M&E exercises & reporting conducted 8.11.5 Number of M&E Studies / field missions to partner institutions using DLIs conducted 8.11.6 Number of Employer tracer studies conducted 8.11.7 Alumnae tracer studies conducted SOURCE OF 8.11.1 Strategic document at centre VERIFICATION 8.11.2 M&E strategy document at centre 8.11.3 Minutes records at centre 8.11.4 Reports at centre records 8.11.5 Reports at centre records 8.11.6 Reports at the centre records 8.11.7 Reports at the centre records IMPLEMENTATION MILESTONES M & E team established by 31/5/2016 PROCUREMENT Consultancies RESPONSIBILITY FOR Centre leadership, Chair M&E, project administrator, IMPLEMENTATION DURATION: 12 months Starting: Q1 Y1 Completion: Q3 Y5 PRIMARY CONSTITUENTS: PARTICIPANTS: CEFTER Team, Board Partners, students faculty ASSUMPTIONS N/A FINANCIAL IMPLICATIONS First Year Y Y Y Y Total Budget Line Analysis Q1 Q2 Q3 Q4 2 3 4 5 USD 5.11.1 Strategic plan draft development 1,980 2,640 - - - - 4,620 5.11.2 Strategic plan finalisation 11,650 - - - - 11,650 5.11.3 M&E Missions (internal) 2,000 2,000 4,000 4,000 4,000 4,000 20,000 5.11 Subtotal 1,980 4,640 11,650 2,000 4,000 4,000 4,000 4,000 36,270

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8. Annexes

8.1a Procurement Manual The procurement procedure will follow established Guidelines as indicated in the links below: 1. https://ppda.go.ug/download/downloads/regulations/cg_regulations/PPDA_ACT-2003.pdf 2. https://ppda.go.ug/download/downloads/regulations/cg_regulations/PPDA%20REGS%202014.zip

8.1b Procurement Plan

User Department Procurement Plan for Supplies, Works, Non Consultancy and Consultancy Services

Area/Section/Department PHARBIOMTRAC Financial Year 2016/2017

Quantity/ Estimated Source of S/ Subject of procurement Unit Date when goods/services/ works are required cost in USD funding measure

1 Benchmarking visits (India) -Air Tickets 7 8,400 ACE October 2016 - November 2016 2 Benchmarking visits (South Africa) Air Tickets 7 7,400 ACE October 2016 - November 2016 3 Benchmarking visits (USA) Air Ticket 7 16,000 ACE October 2016 - November 2016 4 Installation of ICT systems for learning 1 50,000 ACE October 2016 - November 2016 5 Student Handbooks (PhD & Masters) 20 340 ACE November 2016 - December 2016 6 Learning materials (lecturers reference materials, demonstration materials etc.) 24 6,000 ACE November 2016 - December 2016 7 Upgrading Learning Facilities Pharmacology LT 1 70,000 ACE October 2016 - November 2016 8 Lecture rooms upgrade 1 12,000 ACE October 2016 - November 2016 67 | Page

Digital Library / ICT learning centre / video conferencing facilities/ computer 9 1 50,000 ACE January 2017 - March 2017 workstations for students 10 Standby generator (purchase & installation) 1 10,000 ACE October 2076 - November 2016 Advertisement/ assembling of trainers/ Recruitment of students for short courses and 11 1 2,000 ACE December 2017 training 12 Advertisement/ assembling, recruitment of students for Msc and PhD, and training 1 2,000 ACE December 2017 13 Travel (Flights) for Students (return flights) 8 4,800 ACE January 2017 - April 2017 14 30 Seater Bus 1 50,000 ACE December 2016 15 Research Policy and Plan finalisation (Y1 development Y4 review) 10,400 ACE January 2017 - March 2017 16 Pharm-Biotech Laboratory equipment purchase, installation, tear and wear 1 94,500 ACE January 2017 - March 2017 17 Analytical Laboratory, purchase, installation, tear and wear 1 118,500 ACE January 2017 - March 2017 18 Product development Laboratory, purchase, installation, tear and wear 1 188,600 ACE January 2017 - March 2017 19 Monographs (Product Monographs) 2 6,000 ACE April 2017 - August 2017 20 Research support for MSc students 15 21,000 ACE April 2017 - August 2017 21 Research support for PHD students 10 45,000 ACE January 2017 - March 2017 22 Station wagon purchase (4 wheel drive) 1 100,000 ACE October 2016 23 Quality Assurance and M&E consultancy 1 4,000 ACE March 2017 - May 2017 - August 2017 24 Secretariat (furniture, computer, software) 1 23,000 ACE October 2076 - November 2017 25 Access audit 1 2,000 ACE October 2016 - December 2017 26 Facility upgrade 1 4,000 ACE October 2016 - November 2016 27 Dissemination of Research Policy to attract academic staff of the region 1 1,000 ACE March 2017 - May 2017 28 Regional Visiting faculty members - Kenya 1 870 ACE February 2017 29 Regional Visiting faculty members - South Africa 1 870 ACE March 2017 30 Regional Visiting faculty members - Sudan 1 870 ACE April 2017 31 Regional Visiting faculty members - Mozambique 1 870 ACE May 2017 32 Student attachment African Partner - KEMRI - Kenya 4 1,800 ACE January 2017 - December 2017 33 Student attachment African Partner - Gezira University - Sudan 4 3,400 ACE January 2017 - December 2017 34 Community training kits 42 6,300 ACE October 2016 - September 2017 35 Training Centre (Traditional Medical Practitioners) BUMETHA 1 10,000 ACE May 2017 = August 2017 36 Training Centre (Traditional Medical Practitioners) IIACM 1 10,000 ACE May 2017 = August 2018 37 Training Centre (Traditional Medical Practitioners) PROMETRA-Uganda 1 10,000 ACE May 2017 = August 2019 68 | Page

38 Training Centre (Traditional Medical Practitioners) ANAMED 1 10,000 ACE May 2017 = August 2020 39 Training Centre (Traditional Medical Practitioners) NCRL centre 1 10,000 ACE May 2017 = August 2021 40 International Visiting faculty members (USA) 1 2,500 ACE April 2017 - June 2017 41 International Visiting faculty members (India) 1 900 ACE April 2017 - June 2017 42 Sabbatical Place (6 months per year) 1 1,800 ACE April 2017 - October 2017 43 Furniture & Computers] Establishment of PHARMBIOTRAC secretariat 1 23,000 ACE October 2076 - November 2016 44 Installation of ICT systems for finance & administration 1 5,000 ACE October 2016 - November 2016 45 Inception and planning meeting of all partners 1 9,536 ACE December 2016 46 Bi-Annual Meeting by IUCEA 2 3,800 ACE October 2016 - September 2017 47 Partner coordination visits regional (2 ppl) 3 5,400 ACE January 2017, May 2017, April 2018 48 Business clinic (furniture, computer, software) 1 8,800 ACE October 2016 - November 2016 49 Product Exhibitions (Regional) 1 900 ACE October 2016 - September 2017 50 Student Handbooks (in-service professionals short course) 100 1,000 ACE November 2016 - December 2016 51 Student Handbooks (short course for TMPs) 1000 5,000 ACE November 2016 - December 2016 October 2016, November 2016, January 52 Strategic plan finalisation 1 5,200 ACE 2017, March 2017 53 Meeting of Steering Committee 2 1,360 ACE November 2016 - April 2017 TOTAL USD 1,046,116

Prepared by User: Approval by Head of Department Received by Head of PDU

Name:…………………………………………… Name:…………………………………………… Name:……………………………………………

Signature: …………………………………….. Signature: …………………………………….. Signature: ……………………………………..

Date: …………...... ………………. Date: …………...... ………………. Date: …………...... ……………….

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PROCUREMENT PLAN FOR GOODS, WORKS AND NON CONSULTANCY SERVICES-FOR SUBMISSION TO TREASURY, PPDA AND PUBLICATION PDE Name: Financial Year:2016/2017

INVITATION AND AWARD OF BIDS Procur- Contract S/ Estimated Source of Contract PRE-QUAL Completion Subject of procurement Currency ement signing No cost funding Type (Yes or No) Approval Award date method Bid closing/ date Bid invitation date notification Opening date evaluation date report date Benchmarking visits (India) -Air 1 USD 8,400 ACE RDB Lump sum Yes Tickets Benchmarking visits (South 2 USD 7,400 ACE RDB Lump sum Yes Africa) Air Tickets Benchmarking visits (USA) Air 3 USD 16,000 ACE RDB Lump sum Yes Ticket Installation of ICT systems for 4 USD 50,000 ACE RFQ Lump sum Yes learning Student Handbooks (PhD & 5 USD 340 ACE RFQ Lump sum Yes Masters) Learning materials (lecturers 6 reference materials, USD 6,000 ACE RFQ Lump sum Yes demonstration materials etc.) Upgrading Learning Facilities 7 USD 70,000 ACE RFQ Lump sum Yes Pharmacology LT 8 Lecture rooms upgrade USD 12,000 ACE RFQ Lump sum Yes Digital Library / ICT learning centre / video conferencing 9 USD 50,000 ACE RFQ Lump sum Yes facilities/ computer workstations for students Standby generator (purchase & 10 USD 10,000 ACE RFQ Lump sum Yes installation)

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Advertisement/ assembling of 11 trainers/ Recruitment of students USD 2,000 ACE RFQ Lump sum Yes for short courses and training Advertisement/ assembling, 12 recruitment of students for Msc USD 2,000 ACE RFQ Lump sum Yes and PhD, and training Travel (Flights) for Students 13 USD 4,800 ACE RFQ Lump sum Yes (return flights) 14 30 Seater Bus USD 50,000 ACE RDB Lump sum Yes Research Policy and Plan 15 finalisation (Y1 development Y4 USD 10,400 ACE RFQ Lump sum Yes review) Pharm-Biotech Laboratory RDB/ 16 equipment purchase, installation, USD 94,500 ACE Lump sum Yes tear and wear RFQ Analytical Laboratory, purchase, 17 USD 118,500 ACE ODB Lump sum Yes installation, tear and wear Product development Laboratory, 18 purchase, installation, tear and USD 188,600 ACE ODB Lump sum Yes wear Monographs (Product 19 USD 6,000 ACE RFQ Lump sum Yes Monographs) Research support for MSc 20 USD 21,000 ACE RFQ Lump sum Yes students Research support for PHD 21 USD 45,000 ACE RDB Lump sum Yes students Station wagon purchase (4 wheel 22 USD 100,000 ACE ODB Lump sum No drive) Quality Assurance and M&E 23 USD 4,000 ACE RFP Lump sum Yes consultancy Secretariat (furniture, computer, 24 USD 23,000 ACE RFQ Lump sum Yes software) 25 Access audit USD 2,000 ACE RFQ Lump sum Yes

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26 Facility upgrade USD 4,000 ACE RFQ Lump sum Yes Dissemination of Research Policy 27 to attract academic staff of the USD 1,000 ACE Micro Lump sum Yes region Regional Visiting faculty members 28 USD 870 ACE RFQ Lump sum Yes - Kenya Regional Visiting faculty members 29 USD 870 ACE RFQ Lump sum Yes - South Africa Regional Visiting faculty members 30 USD 870 ACE RFQ Lump sum Yes - Sudan Regional Visiting faculty members 31 USD 870 ACE RFQ Lump sum Yes - Mozambique Student attachment African 32 USD 1,800 ACE RFQ Lump sum Yes Partner - KEMRI - Kenya Student attachment African 33 USD 3,400 ACE RFQ Lump sum Yes Partner - Gezira University - Sudan 34 Community training kits USD 6,300 ACE RFQ Lump sum Yes Training Centre (Traditional 35 USD 10,000 ACE RFQ Lump sum Yes Medical Practitioners) BUMETHA Training Centre (Traditional 36 USD 10,000 ACE RFQ Lump sum Yes Medical Practitioners) IIACM Training Centre (Traditional 37 Medical Practitioners) USD 10,000 ACE RFQ Lump sum Yes PROMETRA-Uganda Training Centre (Traditional 38 USD 10,000 ACE RFQ Lump sum Yes Medical Practitioners) ANAMED Training Centre (Traditional 39 Medical Practitioners) NCRL USD 10,000 ACE RFQ Lump sum Yes centre International Visiting faculty 40 USD 2,500 ACE RFQ Lump sum Yes members (USA) International Visiting faculty 41 USD 900 ACE RFQ Lump sum Yes members (India)

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Sabbatical Place (6 months per 42 USD 1,800 ACE RFQ Lump sum Yes year) Furniture & Computers] 43 Establishment of PHARMBIOTRAC USD 23,000 ACE RFQ Lump sum Yes secretariat Installation of ICT systems for 44 USD 5,000 ACE RFQ Lump sum Yes finance & administration Inception and planning meeting of 45 USD 9,536 ACE RDB Lump sum Yes all partners 46 Bi-Annual Meeting by IUCEA USD 3,800 ACE RDB Lump sum Yes Partner coordination visits 47 USD 5,400 ACE RFQ Lump sum Yes regional (2 ppl) Business clinic (furniture, 48 USD 8,800 ACE RFQ Lump sum Yes computer, software) 49 Product Exhibitions (Regional) USD 900 ACE RFQ Lump sum Yes Student Handbooks (in-service 50 USD 1,000 ACE Micro Lump sum Yes professionals short course) Student Handbooks (short course 51 USD 5,000 ACE RFQ Lump sum Yes for TMPs) 52 Strategic plan finalisation USD 5,200 ACE RFQ Lump sum Yes 53 Meeting of Steering Committee USD 1,360 ACE RFQ Lump sum Yes

TOTAL USD 1,046,116 Name:

Signature: Prepared by Designation: Head PDU

Date:

Name:

Signature: Approved by Designation: Accounting Officer

Date:

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8.1c Financial Management Plan The Financial Management Plan of the PHARMBIOTRAC project described here outlines the sources of project funding, budget implementation processes and reporting. 1. Sources of Project Funding The main source of funding or at least the initial financial support for PHARMBIOTRAC project shall come from the World Bank to a tune of about USD 6,000,000 with MUST contributing most of the technical and support staff, as well as operational facilities. A detailed budget for the project has been worked out and included in the PHARMBIOTRAC Implementation Plan. 2. Budget Implementation Budget implementation shall be in accordance to activities set out in the PHARMBIOTRAC Implementation Plan and shall follow the Ugandan Government Financial Regulatory Framework as well as the World Bank guidelines. Implementation of activities will be dependent on the inputs involved. Most inputs require a procurement process while some require direct payments. Requisitions shall be made, and funds shall be committed or encumbered against the budgeted expenditure items to ensure funds availability before authorization and approval are made by the Project Centre Leader and the University Accounting officer. Financial transactions at the PHARMBIOTRAC shall be processed using QuickBooks 2015. However, the University is currently testing a Computerized Education Management and Accounting system (CEMAS) which is a robust information technology platform that automates most financial functions and fully integrates with other Departments of the university like Academic registrar, Procurement, Human Resource and Stores. It is envisioned that when CEMAS becomes fully functional, it will be used for processing of financial transactions of PHRAMBIOTRAC as well. All financial transactions shall be supported with relevant documents such as receipts, invoices, contracts, payment vouchers with EFT numbers, etc and all shall be properly secured for use by other parties as the need may arise. 3. Internal Audit Internal Audit Section of MUST shall carry out a regular and continuous review and assessment of the existing internal controls, compliancy with relevant policies and procedures as well as analysing risks and their mitigation measures. Internal Audit Section shall regularly issue reports accordingly. 4. Payment Process The payment and expenditure process at PHRAMBIOTRAC shall follow procedures as summarized in the Flow Chart below:

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5. Reporting The accounting software used shall provide reports such budget performance, statements of financial performance and position for management use and other stake holders. It will also be the source of information for customized reports as the Donor may require.

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