327

INDEX

Acetate, administration of, in parenteral 50-52 nutrition support, 102 diagnostic tests for, 52-53 Acetominophen, 211, 213 prevention of, 55-58 Acidosis, correction of, with parenteral Aminoglycosides, nephro- and ototoxicity of, nutrition support, 102 11 Actinomycin D, 89 Amekacin, nephrotoxicity of, 11 Acylampicillins, toxic effects of, 10-11 Amphotericin B, chemical structure of, 16 Adenine diphosphate, effect of aspirin on, 212 combined with 5-flucytosine, for crypto- Adolescence, cancer statistics for, 291, 292 coccosis, 30 concept of body image during, 284-85 for aspergillosis, 27 coping strategies for disease during, 289-90 for candidiasis, 23, 24 current approach to cancer care during, for coccidioidomycosis, 31 281-82 for histoplasmosis, 32 emotional and physical development during, for mucormycosis, 28 282-86 for trichosporon infection, 31 general principles for management of cancer interaction of, with granulocyte trans- during, fusions, 73 activities, 298-99 pharmacokinetics of, 17 bereavement follow-up, 305 toxic effects of, 19 birth control, 300 Analgesic(s). See also names of specific drugs diagnosis, 293 classifications of, 206, 207 discussion of diagnosis, 293-98 controversial,231-33 financial expenses, 301-02 equianalgesic comparison of, 222-25 home care, 302-03 guidelines for selection and use of, 208 school program, 299-300 mechanisms of action by, 208-11 sibling care, 300-01 narcotic, supportive care, 298 cardiovascular effects of, 221 psychological impact of illness and hospital• chemical classifications of, 216, 218 ization during, 287-89 effects of, on central nervous system, Adriamycin, emesis caused by, 89 219 hematopoietic effects of, 179 effects of, on endocrine system, 221 Aged. See Elderly effects of, on urinary tract, 220-21 Agglutinin test, use of, in diagnosis of gastrointestinal effects of, 220 candidiasis, 22 guidelines for selecting, 221, 226-27 Agranulocytosis. See GranUlocytopenia new methods for administration, Alizapride, 85 227-31 Alkalosis, correction of, with parenteral pharmacologic activity of, 217 -18 nutrition support, 102 respiratory effects of, 219-20 Alloimmu"ization, and granulocyte transfusion, withdrawal from, 226 72-73 narcotic antagonists, 216 development of, from platelet transfusions, non-narcotic, 211-15 328

Anemia, as toxic side effect, BCND, latent hematopoietic damage induced of amphotericin B, 17 by, 177 of miconazole, 18 Benadryl. See Anorexia, as toxic side effect of amphotericin Benzamides, substituted, antiemetic properties B,17 of,85-86 Antibiotic therapy. See also names of specific Bicarbonate, use of, to reduce antifungal• drugs induced renal damage, 17 combination regimes of, 5-7 Biliary bypass surgery, 141-42 determining choice of, 4 Birth control, for adolescent cancer patients, optimal duration of, 8-10 300 response rates to, 4 Body image, adolescent, 284-85 side effects of, 10-11 impact of illness on, 285, 287 Antibody testing, for platelet transfusions, role of, in enterostomal therapy, 261, 269, 54-55 272 Antiemetic agents. See also names of specific role of, in psychological aspects of breast drugs cancer, 240-42 antihistamines as, 84 Bone, changes in, as complication of radiation butyrophenone derivatives as, 85 therapy, 161-62 cannabinoids as, 86-87 Bone marrow, cryopreservation of, 191-92 corticosteroids as, 87 reconstitution of, with infusions of autologous phenothiazine compounds as, 83-84 hematopoietic stem cells, 184-92 practical guide to use of, 89-90 Bradycardia, association of, with retching, 80 refractoriness of pre-treatment emesis to, 83 Brain, mucormycosis infection in, 28 substituted benzamides as, 85-86 Breast cancer, psychological aspects of. See Antifungal agents, 16-19. See also names of Mastectomy specific drugs "Brompton's cocktail", analgesic properties of, Antifungal therapy, initiation of, 9 231-32 Antigens, matching of, in donor selection, Bronchoscopy, risks of, in thrombocytopenic 53-54 patients, 49 for prevention of alloimmunization, 56 Burkitt's lymphoma, treatment of, with auto• Antihistamines, antiemetic properties of, 84 logous bone marrow reconstitution, 187 -88 Anxiety, as emotional response in adolescent Busulfan, latent hematopoietic damage induced cancer patient, 288 by, 177, 178-79 pre-operative, with breast cancer, 240 Butyrophenone derivatives, antiemetic proper• physician handling of, 242-47 ties of, 85 post-operative, in ostomy patients, 261, 269-70,273 Caffeine, 212 Apomorphine, vomiting induced by, 80 Calcium, administration of, in parenteral effect of halperidol on, 85 nutrition support, 102, 103 effect of metodopramide on, 86 Calcium leucovorin, hematopoietic effect of, effect of phenothiazine compounds on, 83, 84 combined with methotrexate, 180-81 Ara-C. See Cytosine arabinoside Caloric requirements, as based on basal energy Arachidonic acid, 209-10 expenditure, 98 Aspergillosis, clinical manifestations of, 26 Candidaalbicans, 16, 19,20 diagnostic tests for, 26 Candida parapsilosis, 19 epidemiology of, 25-26 Candida tropicalis, 19, 20 therapy for, 27 Candidiasis, clinical manifestations of, 20-21 Aspirin, therapeutic effect of, on cancer• diagnostic tests for, 21-23 related pain, 211-13 epidemiology of, 19 Asthma, bronchial, development of, from therapy for, 23-25 aspirin allergy, 212 Cannabichromene, 86 Atropine, antiemetic properties of, 85 Cannabidiol, 86 Azlocillin, use of, in com bination therapy, 6-7 Cannabinoids, antiemetic properties of, 86-87 Carbenicillin, advantages of, in combination 329

therapy, 5-7 management of, 128-29, 133-35,138 effects of, 10-11 Colostomy, therapy for. See Enterostomal nephrotoxicity of, 11 therapy Catheter sepsis, as complication of parenteral Compazine. See Prochlorperazine nutrition support, 11 0-12 Complement fixation test, for candidiasis, 22 Cefazolin, advantages of, in combination for cryptococcosis, 29-30 therapy, 6 Constipation, management of, in ostomy nephrotoxicity of, 11 patients, 261-62 Cefoperazone, use of, with acylampicillins, 6-7 Copper, administration of, in parenteral Cefotaxime, use of, with acylampicillins, 6-7 nutrition support, 103 Central nervous system, cryptococcal infection Copper sulfate, emesis caused by, 81 of,29 effect of antihistamines on, 84 effect of narcotic analgesics on, 219 effect of atropine and scopolamine on, 85 Cephalosporin(s). See also names of specific Corticosteroids, antiemetic properties of, 87 drugs contraindications to use of, 90 toxic effects of, 10-11 Cryopreservation of bone marrow, 191-92 use of, in combination therapy, 5-7 Cryptococcosis, clinical manifestations of, 29 Cephalothin, advan.tages of, in combination diagnostic tests for, 29-30 therapy, 6 epidemiology of, 28-29 nephrotoxicity of, 11 therapy for, 30 CFU-S assay, described, 172 Cyclizine, antiemetic use of, 84 Chemoreceptor trigger zone, role of, in neuro• Cyclophosphamide, emesis caused by, 89 anatomy of vomiting, 80-81 hematopoietic effects of, 176, 178, 179 Chemotherapy, as contributing factor in hematopoietic protection with priming dose development of infection, 1 of, 182 as emetic stimulus, 88-89 Cytomegalovirus, acquisition of, from granulo• continuous infusion, for hepatic metastases, cyte transfusion, 73 - 74 138-39 Cytosine arabinoside, emesis caused by, 89 oral manifestations of, for remission of acute myeloid leukemia, 63, dental caries, 149 64 periodontal bleeding, 150 hematopoietic effects of, 176 salivary changes, 149 Cytoxan. See Cyclophosphamide stomatitis, 147 -4 9 role of, in control of cancer-related pain, 206 Daunomycin, emesis caused by, 89 Chloramphenicol, 7 Daunorubicin, hematopoietic effects of, 176 Chlorethyl nutrosoureas, emetogenic properties Death and dying, impact of, on patient, 31 i-IS of, 88-89 impact of, on physicians, 312-13, 315 -1 7 Chloride, administration of, in parenteral special problems of terminal patient, 311-12 nutrition support, 102 Delta-9-THC, antiemetic properties of, 86 Chlorpheniramine, 84 Dental caries, caused by chemotherapy, 149 , 83, 84 caused by radiation therapy, 159-60 Chlortrimeton. See Chlorpheniramine Dental extractions, in myelo- and immuno• Cholangiojejunostomy, 141-42 suppressed patients, 156 Cholangitis, 141 pre-irradiation, 163-64 Chromium, administration of, in parenteral post-irradiation, 166 nutrition support, 103 Dental treatment for myelo- and immuno• Cis-diamminedichloroplatinum, emetogenic suppressed patients, 153-56. See also properties of, 88 Oral hygiene Clindamycin, 7 Dexamethasone, antiemetic properties of, 87 , use of, in "Brompton's cocktail", , 232 231-32 Diarrhea, as side effect of miconazole, 18 Coccidioidomycosis, 31 management of, in ostomy patients, 261, 263 Codeine, 211, 212 Dimenhydrinate, antiemetic properties of, 84 Color ectal carcinoma, metastatic, surgical Dimethylsulfoxide, for cyropreservation of 330

pia telets, 57 parenteral nutrition support, 101 Diphenhydramine, antiemetic properties of, 84, Felty's syndrome, use of lithium carbonate 90 for, 182 Donor selection, 53-54 Fenoprofen, 213 platelet antibody testing for, 54-55 Fentanyl citrate, combined with droperidol, to Dopamine, 17 induce neuroleptanalgesia, 85 Dopamine receptors, role of, in molecular Fever. See also Infection biology of emesis, 81-82 as symptom of cryptococcal meningitis, 29 Dramamine. See Dimenhydrinate as side effect of amphotericin B, 17 Droperidol, antiemetic properties of, 85 as side effect of miconazole, 18 D~.;phagia, as symptom of candidiasis, 20 factors responsible for, in neutropenic patient, 2 Edema, oral, from radiation therapy, 160 granulocyte transfusion for, 71 Electrolytes, administration of, in parenteral Filtration leukapheresis, 64, 66 nutrition support, 102-03 Financial expenses, consideration of, in Electrolyte balance, monitoring of, 108-09 management of cancer patient, 301-02 Elderly, measures of religious belief among, 5-Flucytosine, combined with amphotericin B, 320 for candidiasis, 24 Emesis. See also Antiemetic drugs for cryptococcosis, 30 anatomy of, 79-80 Fluid balance, monitoring of, in parenteral as homeostatic regulatory mechanism, 79 nutrition support, 108 chemotherapeutic agents as stimuli to, 88-8<'; 5-FluorouraciJ, continuous infusion therapy molecular biology of, 81-82 with,139 neuroanatomy of, 80-81 emesis caused by, 89 pre-treatment, 83 Fluphenazine, antiemetic use of, 84, 89 Endocrine system, effects of narcotic Fracture, pathologic, 139-40 analgesics 0 n, 221 Fungal infections. See also Antifungal agents Endoq:hins, function of, 208-09 epidemiology of, 15 -16 Enterocolitis, granulocyte transfusion for, 71 Enterostomal therapy, development of, as Gas, management of, in ostomy patients, 267 nursing specialty, 253-55 Gastrointestinal tract, effects of narcotic post-surgical interventions in, 257-58 analgesics on, 220 pre-hospital discharge planning in, 258-59 involvement of, in candidiasis, 20 pre-surgical interventions in, 255-56 surgical management of recurring malignancy problems of psychological adjustment in, in, 133-35 271-74 Gentamicin, 7 protocols for management of Glucocorticosteroids, administration of, for abnormal bowel eli'1lination, 261-63 granulocyte procurement, 66 anxiety, 269-71 Glucose intolerance. See Hyperglycemia appliances, 259-61 Graft versus host reaction, granulocyte gas, 267 transfusions as cause of, 74 irrigation equipment, 265-67 Granulocyte concentrate, kinetics of, 67 nutritional intake, 265 procurement of, 64-67 odor, 267-68 storage of, 67-68 sexual adjustment, 268-69 Granulocyte transfusion, and alloimmunization, skin care, 263-64 72-73 review of related research on, 274-77 and interaction with amphotericin B, 73 Erythema, as complication ofradiation therapy, as cause of graft versus host reaction, 74 157 background of, 63-64 Escherichia coli, 2 cytomegalovirus transmission from, 73-74 Ethanol. for treatment of pain, 143 dosages in, 67 Ethoheptazine, 212 frequency and duration of, 72 general complications from, 72 Fatty acids, essential, administration of, in mechanics for effects of, 74-75 331

method of, 68 Histaminereceptors, role of, in molecular biol• monitoring of, 71-72 ogy of vomiting, 81-82 prophylactic use of, 69 Histoplasmosis, 31-32 therapeutic use of, 69-71 Hodgkin's disease, and presence of cryptococ• Granulocytopenia, and development of con• cosis,29 current infection, 1-2 Home care, cost effectiveness of, 301-02 Granulopoiesis, effect of lithium carbonate on, for adolescent patients, 302-05 181-82 Hydromorphine hydrochloride, 233 Gut, as route of administration for nutritional Hydroxyethyl starch, use of, in granulocyte support, 96 procurement, 66 Gynecomastia, as side effect of ketoconazole, Hyperglycemia, management of, with parenteral 19 nutrition support, 98, 99, 104-05 Hypertriglyceridemia, as side effect of Haldo!. See Haloperidol miconazole, 18 Haloperidol, antiemetic properties of, 85 management of, with parenteral nutrition Head, surgical management for recurring support, 99 sarcomas of, 135-36 Hypoglycemia, prevention of, with parenteral Headache, as symptom of cryptococcal menin• nutrition support, 105 gitis, 29 Hypokalemia, as toxic side effect of antibiotic as side effect of amphotericin B, 17 therapy, 10 as side effect of ketoconazole, 19 Hyponatremia, as side effect of miconazole, 18 Hematopoiesis, blood-marrow barrier in, 175 in vitro assays for, 172-73 Ibuprophen, 213 humoral regulation of, 175 Ileostomy, therapy for. See Enterostomal methods for studying, 170 therapy microenvironmental and stromal influences Imidazole carboxamide, emetogenic properties on, 173-75 of, 88 stem cells and progenitor cells in, 171-73 Immunofluorescent antibody test, for diagnosis Hematopoietic toxicity, in vitro studies of, of candidiasis, 22 175-79 Inapsine. See Droperidol pharmacologic and cytokinetic protection Indomethacin, 213 from, Infection, antibiotic therapy for, 3-4 with infusions of autologous hematopoietic combination regimens of, 5-7 stem cells, 184-92 optimal duration of, 8-10 with lithium carbonate, 181-82 side effects of, 10-11 with methotrexate and calcium leucovorin, as complication of parenteral nutrition 180-81 support, 110-12 with priming dose of cyclophosphamide, bacterial, 1-3 182 common sites for, in neutropenic patients, 2 with radioprotecting agent WR2721, cytomegalovirus, acquisition of, 73-74 182-83 diagnosis of, 2-3 Hemorrhage, and template bleeding time test fungal, 15-16 of platelet function, 47-48 management of, in ostomy patients, 263 oral, 154 granulocyte transfusion for, 70-71 prophylactic platelet transfusion for, 48 Innovar. See Fentanyl citrate uterine, suppression of menstruation to Internation81 Association of Enterostomal prevent, 149 Therapy, 254 Hepatic artery ligation, 136-38 Irrigation, management of, in ostomy patient, Hepatic function, monitoring of, in parenteral 265-67 nutrition support, 109 Hepatic lobectomy, 129-30 Jaundice, surgical treatment for, 140-42 Hepatitis, as toxic effect of ketoconazole, 19 Hepatojejunostomy, 141-42 Ketoconazolc, antifungal activity of, 18-19 , 232-33 drug interactions with, 19 332

for aspergillosis, 27 248-49 for candidiasis, 25 Mechlorethamine HCl, emetogenic properties for coccidioidomycosis, 31 of, 88 for histoplasmosis, 32 Mefenamic acid, 211, 214 pharmacokinetics of, 19 Melphalan, and development of subsequent toxic effects of, 19 neoplasms, 179 Kidney, effects of aminoglycosides on, 11 hematopoietic effects of, combined with Klebsiella pneumoniae, 2 cyclophosphamide, 182 treatment for, 6 Meningitis, cryptococcal, 29 therapy for, 30 Lactobacillus, 159 Menstruation, suppression of, to prevent L-asparaginase, emesis caused by, 89 uterine hemorrhage, 49 Latex agglutination test, for diagnosis of Mentazocine, 211 cryptococcosis, 30 Mepazine, 84 Leukemia, chronic myelogenous, autologous Meperidine, for treatment of granulocyte hematopoietic reconstitution for, 190 transfusion reactions, 72 Leukocytes, polymorphonuclear neutrophilic, Metabolic disorders, 94-95 67-68 Metabolic function, monitoring of, in parenteral Leukopenia, as side effect of miconazole, 18 nutrition support, 109 Levonantradol hydrochloride, antiemetic Metastatic disease, importance of histologic properties of, 86-87 confirmation of, 125-27 Lithium carbonate, granulopoietic effects of, gastroin testinal, 13 3- 35 181-82 hepatic, 127-30 Liver. See also under Hepatic metastases of, pulmonary, 130-33 127-30 therapy for, 136-39 and surgical treatment of jaundice, 140-42 Methotrexate, emesis caused by, 89 hepatic artery ligation for, 136-38 hematopoietic effects of, infusion chemotherapy for, 138-39 combined with ara-C or velban, 176 L-phenylalanine mustard, hematopoietic effects combined with calcium leucovorin, 180-81 of, 178 Methylmethacrylate, for treatment of pathologic Lung. See also under Pulmonary aspergillosis fractures, 140 infection in, 26 Methylprednisolone, antiemetic properties of, metastases of, 130-33 87 mucormycosis infection in, 28 Metoclopramide, antiemetic properties of, Lymph node, excision of regional metastases 85-86,90 in, 127 Mezlocillin, advantages of, in combination Lymphocytotoxic antibody, measurement of, as therapy, 6-7 test for alloimmunization, 52-53 response rate to, 5 Miconazole, antifungal activity of, 17-18 Malnutrition, as result of metabolic disorders, effect of, on warfarin, 18 94-95 for aspergillosis, 27 Magnesium, administration of, in parenteral for candidiasis, 25 nutrition support, 102, 103 pharmacokinetics of, 18 Manganese, administration of, in parenteral toxic effects of, 18 nutrition support, 103 Mithramycin, 89 Mannit"l, use of, to reduce antifungal-induced Morphine, compared to heroin, 232-33 renal damage, 1 7 intraspinal administration of, 229-31 Mastectomy, and management of pre-operative intravenous infusion of, 227 -29 anxiety, 242-47 use of, in "Brompton's cocktail", 231-32 post-operative reactions to, 247 Motion sickness, treatment for, 84, 85 physician management of, 247-51 Mouth. See under Oral role of body image and emotional attitudes Moxalactam, nephrotoxicity of, 11 in psychological adjustment to, 240-41 use of, in combination therapy, 6-7 role of husband in patient adjustment to, Mucormycosis, clinical manifestations of, 28 333

diagnostic tests for, 28 vitamins and trace elements in, 103 epidemiology of, 27-28 rationale for, 93-95 therapy for, 28 Mucositis, as complication of radiation therapy, Oral complications, 157-58 of chemotherapy Muscarinic cholinergic blocking agents, anti• dental caries, 149 emetic properties of, 84-85 periodontal bleeding, 150, 154 Muscarinic cholinergic receptors, role of, in salivary changes, 149 molecular biology of emesis, 81-82 stomatitis, 147-49 Mycobacterium tuberculosis, 2 of radiation therapy bone changes, 161-62 Nabilone, antiemetic properties of, 87 dental caries, 159-60 Naloxone, as antidote to propoxyphene over- edema, 160 dose, 216 erythema, 159 Naproxen,214 mucositis, 157-58 Narcotic analgesics. See Analgesics, narcotic periodontal changes, 160 Narcotic antagonists, 216 salivary changes, 158-59 Nausea. See also Emesis trism us, 161 defined, 79 Oral hygiene, for chemotherapy patients, as toxic effect of ketoconazole, 19 150-53 as toxic effect of miconazole, 18 for irradiated patients, 163-65 Neck, surgical management for recurring Osteoradionecrosis, 165 sarcomas of, 135-36 Ostomy, therapy for. See En terostomal therapy Neutrophils, polymorphonuclear, use of, in Ototoxicity, as side effect of antibiotic granulocyte transfusion, 67 therapy, 11 Nutritional disorder, as distinct from metabolic Oxycodone,212 disorder, 95 Oxyphenbutazone,214 Nutritional intake, management of, in ostomy patients, 263, 265 Pain, cancer-related, Nutritional support, effect of, on quality of acute, defined, 200 life, 97 chronic, defined; 200 enteral, evaluation of, 202 administration of, 120 incidence and severity of, 200-02 blendcrized formulas for, 116 mechanisms of, 204 chemical-defined formulas for, 118 pharmacologic control of. See Analgesics complications of, 120-21 primary control of, 204-06 free amino acid formulas for, 118-19 psychologic aspects of, 203-04 lactose-frec'formulas for, 117 role of religion intolerance for, 324 milk-based formulas for, 117 surgical relief of, 142-43 home delivery supply services for, 98 symptomatic control of, 206-08 indications for use of, 96-98 Penicillin K, use of, for post-irradiation dental parenteral, extractions, 166 calculation of nutritional and metabolic Pentazocine, analgesic propcrties of, 212, 216 requircments in, 99 Perazil. See Cyclizine calories and protein in, 98-101 Pericoronitis, 156 electrolytes in, 102-03 Periodontal damage, from chcmotherapy, 150 essential fatty acids in, 101 from radiation therapy, 160 home setting for, 114 Perphenazine, antiemetic properties of, 84 infedion as complication of, 110-12 Pharyngitis, 3 infusion rates for, 103-05 Phcnacetin, 211, 212 monitoring procedures for, 105-10 Phenobarbital, 212 standard formulas for, 100, 101 Phenothiazine(s), administration of, 89 substrate intolerances as complication uf, antiemetic properties of, 83-84 111-14 combined use of, with corticosteroids, 89-90 334

Phenylbutazone, 214 on, 9'1 Phlebitis, as toxic side effect, proportional impact of pain on, 201 of amphotericin B, 17 ofmiconazole,18 Radiation therapy, oral complications from, Phosphorus, administration of, in parenteral bone changes, 161-62 nutrition support, 102, 103 dental caries, 159-60 Piperacillin, use of, in combination therapy, edema, 160 6-7 erythema, 157 Platelet(s), antibody testing, 54-55 mucositis, 157-58 collection and storage of, 45 -4 7 periodontal changes, 160 cryopreservation of, 57-58 salivary changes, 160 Platelet transfusion therapy, advances in, 45 trismus, 161 determining dosage in, 50 other side effects of, 163 donor selection in, 53-54 role of, in control of cancer-related pain, indications for use of, 47-50 128,205-06 prophylactic use of, 48-49 Radioprotectors, defined, 182 side effects of, 50-52. See also Alloimmu- Reglan. See Metoclopramide nization Religion, as supportive care, 319-24 Pneumonitis, granulocyte transfusion for, 70 measurement of attitudes toward, Polymixin, 7 among the elderly, 320 Potassium, administration of, in parenteral among terminal patients, 320-23 nutrition support, 102 Renal function, abnormal, as toxic side effect supplemental, for hypokalemia, 10 of amphotericin B, 17 Precipitin test, diagnostic use of, monitoring of, in parenteral nutrition for aspergillosis, 26 support, 109 for candidiasis, 22-23 Respiratory system, effects of narcotic Procar bazin e, 89 analgesics on, 219-20 Prochlorperazine, antiemetic use of, 83, 89 Rifampicin, combined with amphotericin B, Prolizin. See Fluphenazine for aspergillosis, 27 Promazine, analgesic use of, 211,212 for candidiasis, 24 antiemetic use of, 84 interaction of, with ketoconazole, 19 Promethazine, 84 Roux-en-Y biliary enteric drainage, 141 Propoxyphenc compounds, adverse effects of, 216 Salivary changes, from chemotherapy, 149 analgesic use of, 211, 212 from radiation therapy, 158-59 Prostaglandin, 210-11 Saliva substitutes, 164-65 effect of aspirin on, 213 Salmonella, 2 Protein, requirements of, during acute stress, Sarcomas, head and neck, surgical management 99 of, 135-36 Pruritis, as toxic side effect, Saralasin, 17 of ketoconazolc, 19 Scopolamine, antiemetic properties of, 85 of miconazole, 18 Sepsis. See Infection Pseudomonas aeruginosa, 2 Septicemia, granulocyte tramfusion for, 70 combination therapy for, 6 Sexual adjustment of ostomy pati~nts, 268-69 Pseudopetrillidium boydii, described, 30-31 Sodium, administration of, in parenteral effect of miconazole on, 18 nutrition support, 102 resistance of, to amphotericin B, 16 Staphylococcus aureus, 2 resistance of, to kctoconazoic, 19 Staphylococcus epidermis, 2 Pulmonary candidiasis, 20 Stomatitis, as side effect of chemotherapy, diagnostic test for, 21 147-49 Pulmonary cryptococcosis, 29 Streptococcus mutans, 159 therapy for, 30 Streptomyces nodosis, 16 Strcptozotocin, 88 Quality of life, effect of nutritional support Stress, coping strategies for, in adolescence, 335

289-90 Ticarcillin, advantages of, in combination neurohumoral response to, 94 therapy, 5-7 psychological, in response to cancer diag• toxic effects of, 10, 11 nosis,288-89 Tolmetin,214 Sulfamethozazole, toxic effects of, 11 Torecan. See Thiethylperazine use of, in combination therapy, 7 Toxicity, antibiotic, 10-11 Sulindac,214 hematopoietic, see Hematopoietic toxicity Surgery, for control of cancer-related pain, Trace elements, administration of, in parenteral 142-43,205 nutrition support, 103 . for hepatic metastases, 128-30, 136-38 Trichosporon, 31 for pathologic fractures, 139-40 Triflupromazine, antiemetic properties of, 83 for pulmonary metastases, 130-33 Trilafon. See Perphenazine for recurring sarcomas of head and neck, Trimethoprim, toxic effects of, 11 135-36 use of, in combination therapy, 7 for regional recurrence of gastrointestinal Trismus, as complication of radiation therapy, malignancy, 133-35 161 for treatment of jaundice, 141-42 Typhlitis, 143-44 Survival data, for metastatic disease, of the liver, 127-30, 138, 139 Ureterostomy, therapy for. See Enterostomal of the lung, 130-33 therapy for regional recurrence of gastrointestinal Urinary tract, candidiasis in, 20 malignancy, 135 effects of narcotic analgesics on, 20

Tachycardia, as side effect of delta-9-THC, Vancomycin, nephro- and ototoxicity of, 11 86 Velban, hematopoietic effects of, 176 association of, with nausea, 79 Vestrin. See Triflupromazine Template bleeding time, as test 'Of platelet Vincristine, hematopoietic effects of, 176 function, 47-48 Vitamins, administration of, in parenteral Terminal patients, adolescent, nutrition support, 103 emotional and psychological problems for Vomiting. See Emesis family of, 305 home care for, 304-05 Warfarin, 18 impact of, on physicians, 312-13, 315-17 WR2721, hematopoietic protection afforded by, psychological changes in, 313-15 182-83 special problems of, 311-12 THC. See Delta-9-THC Xerostomia, as side effect of chemotherapy, Thiethylperazine, antiemetic use of, 83-84, 89 149 Thioridazine, 84 as side effect of radiation therapy, 158-59 Thorazine. See Chlorpromazine Thrombocytopenia, prophylactic platelet Zinc, administration of, in parenteral nutrition transfusion for, 48 support, 103 Thrombocytosis, as side effect of miconazole, Zomepirac sodium, analgesic properties of, 211, 18 214,315-16