Appendix A

Ovid MEDLINE(R) 1946 to Present with Daily Update+ In-Process & Other Non- Indexed Citations (2016 Month, Date) # Search Statement Annotation exp Urinary Bladder Calculi/ or exp Urinary Calculi/ or exp Kidney Calculi/ or exp Ureteral Calculi/ or exp 1 Urolithiasis/ or exp Nephrolithiasis/ or exp Renal Colic/ or exp Ureteral Diseases/ or exp Ureteral Obstruction/ or exp Kidney Diseases/ ((Urin* or renal or kidney or ureter* or bladder) adj3 2 (stone* or calcul* or colic* or lith* or obstruct* or occlusi*)).mp. 3 ((Kidney or ureter*) adj2 diseas*).mp. 4 (Urolith* or nephrolith*).mp. 5 or/1-4 Population- Renal colic exp Anti-Inflammatory Agents, Non-Steroidal/ or exp 6 Inhibitors/ or exp Cyclooxygenase 2 Inhibitors/ ((Nonsteroidal adj2 antiinflammatory) or (Non-steroidal adj2 antiinflammatory) or (Nonsteroidal adj2 anti- 7 inflammatory) or (Non-steroidal adj2 anti- inflammatory)).mp. exp / or exp / or exp apazone/ or exp / or exp / or exp / or exp Salicylates/ or exp / or exp / or exp 8 indomethacin/ or exp / or exp / or exp / or exp / or exp / or exp / or exp aminosalicylic acid/ 9 NSAID*.mp. (Diclofenac or adiflam or agile or diclonac or dicol or 10 diclonat* or feloran or voltarol or Voltaren or Cataflam or Voltaren-XR or Zipsor).mp. ( or Hifenac or Cincofen or Nacsiv or 11 Acenac).mp. (Ketorolac or toradol or torolac or kealc or kenalfin or 12 ketlac).mp. 13 (Apazon* or Azapropazon* or cinnopropazon*).mp. (Aspirin* or acetylsal* or dispril or easprin* or 14 salicylic*).mp. (Ibuprofen or brufen or nuprin or rufen or salprofen or dolgit or salprofen or advil* or motrin or nurofen or 15 actiprofen or addaprin or aktren or anadin or bugesic or ibuprox).mp. (ketoprofen or orudis or oruvail or ketoflam or oruvail or 16 fastum or ketonal or ketodol or knavon or actron or ketoprofeno).mp. ( or keral or enantyum or ketesgel or 17 dolmen).mp. (Naproxen or naprosyn or naprosin or proxen or synflex 18 or Aleve or Anaprox or Apronax or Naprelan).mp. (etodolac or ramodar or ultradol or etova or dualgan or 19 etodin or etopan or flancox or proxym or etodine or dolarit).mp. (Indomethacin* or indocid or indocin or indomet or 20 or metindol or osmosin).mp. (Piroxicam or feldene or dolocare or dolonex or 21 ketolin).mp. 22 ( or mobic or vivlodex).mp. 23 ( or mobiflex).mp. 24 (celecoxib or celebrex or celebra).mp. 25 ( or vioxx or ceoxx or ceeoxx).mp. 26 ( or bextra).mp. (Nimesulid* or aulin or mesulid or nimalox or sulid* or 27 sintalgin or nimsid* or nise or nimulid).mp. 28 (Meclofenamic or meclofenamat* or meclomen).mp. 29 (fenoprofen or fenopron).mp. ( or oxaprozinum or daypro or dayrun or 30 duraprox).mp. 31 (sulindac or cinoril or imbaral).mp. 32 (tolmetin or tolectin).mp. (* or sulindac* or mesalazin* or sulfasalazin* or flufenamic* or tolmetin* or fenoprofen* or * or niflumic* or ketorolac or trometamol* or * or teriflunomid* or * or * or * 33 or mebron* or mepirizole* or mepyrizole* or methopyrimazole* or Epirizolum* or Polihexanid* or Dalex* or Miton* or epirizol* or * or tolemetin* or nabumeton*).mp. 34 or/6-33 NSAIDS exp , / or exp alkaloids, / or exp 35 narcotics/ 36 opioid*.mp. exp / or exp / or exp / or exp meperidine/ or exp / or exp 37 / or exp Morphine Derivatives/ or exp / or exp / or exp / 38 exp / or alfentanil*.mp. 39 exp / or codein*.mp. (hydrocodon* or vicodin* or norco or lortab or 40 zohydro).mp. 41 exp / or oxycodon*.mp. (dextropropoxyphen* or darvon or darvocet or digesic or 42 capadex).mp. 43 exp / or dihydromorphin*.mp. (fentanyl or actiq or duragesic or fentora or sublimaz* or 44 fenta).mp. 45 (meperidin* or demerol or pethidin*).mp. (methadon* or dolophin* or methadose or amidon* or 46 symoron or physephton* or heptadon).mp. (morphin* or oramorph or morphia or duramorph or 47 contin or mscontin or sevredol or zomorphzomo).mp. 48 (oxymorphon* or numorphan or opana or morphon).mp. (pentazocin* or fortal or sosegon or talwin or fortwin or 49 talacen).mp. 50 (tramadol or ultram).mp. 51 or/35-50 52 exp Acetaminophen/ (abenol* or acamol* or acenol* or acephen* or acet suppositories* or acetalgin* or acetamino phenol* or acetaminophen* or acetaminophene* or acetaminophenol* or acetamol* or acetomenophen* or acetylaminophenol* or adorem* or afebrin* or algiafin* or algotropyl* or alphagesic* or alvedon* or amadil* or anacin 3* or anaflon* or analgiser* or apamide* or apirex* or arthralgen* or benuron* or biogesic* or calapol* or 53 calodol* or dafalgan* or depyretin* or dirox* or dolex* or dolofen* or dolomol* or calpol* or eneril* or meforagesic* or dolorol* or metagesic* or napamol* or naprex* or pacemol* or pacimol* or duorol* or pamol* or panadol* or panamax* or panodil* or paracet* or paracetamole* or parageniol* or paragin* or paralen* or paralief* or paramax* or paramidol* or paximol* or paratabs* or perfalgan* or pyrigesic* or setamol* or tylenol* or tylex* or valadol* or winadol* or zydinol).mp. 54 or/52-53 55 5 and 34 and 51 NSAIDS Vs Opioids 56 5 and 34 and 54 NSAIDS Vs Paracetamol 57 randomized controlled trial.pt. 58 controlled clinical trial.pt. (random$ or placebo$ or single blind$ or double blind$ or 59 triple blind$).ti,ab. 60 (retraction of publication or retracted publication).pt. 61 or/57-60 RCTs 62 (animals not humans).sh. ((comment or editorial or meta-analysis or practice- 63 guideline or review or letter or journal correspondence) not "randomized controlled trial").pt. (random sampl$ or random digit$ or random effect$ or 64 random survey or random regression).ti,ab. not "randomized controlled trial".pt. 65 or/62-64 non-human subject or non RCTs 66 61 not 65 Human subject RCTs NSAIDS Vs Opioids 67 55 and 66 +Human subject RCTs NSAIDS Vs 68 56 and 66 Paracetamol+Human subject RCTs NSAIDS (Opioids or 69 67 or 68 paracetamol) in human subject RCTs

Embase Classic+Embase 1947 to 2016 Month, Date

# Search Statement Annotation exp kidney pain/ or exp kidney colic/ or exp bladder stone/ or 1 exp ureter stone/ or exp urolithiasis/ or exp nephrolithiasis/ or exp ureter obstruction/ 2 ((Urin* or renal or kidney or ureter* or bladder) adj3 (stone* or calcul* or colic* or lith* or obstruct* or occlusi*)).mp. 3 ((Kidney or ureter*) adj2 diseas*).mp. 4 (Urolith* or nephrolith*).mp. Population- Renal 5 or/1-4 colic exp nonsteroid antiinflammatory agent/ or exp cyclooxygenase 2 inhibitor/ or exp indometacin/ or exp piroxicam/ or exp acetylsalicylic acid/ or exp celecoxib/ or exp diclofenac/ or exp ibuprofen/ or exp naproxen/ or exp 6 azapropazone/ or exp acetylsalicylic acid/ or exp ketoprofen/ or exp / or exp ketorolac/ or exp ketoprofen/ or exp salicylic acid derivative/ or exp etodolac/ or exp fenoprofen/ or exp sulindac/ or exp tolmetin/ or exp mesalazine/ or exp aminosalicylic acid/ ((Nonsteroidal adj2 antiinflammatory) or (Non-steroidal adj2 7 antiinflammatory) or (Nonsteroidal adj2 anti-inflammatory) or (Non-steroidal adj2 anti-inflammatory)).mp. 8 NSAID*.mp. (Diclofenac or adiflam or agile or diclonac or dicol or diclonat* 9 or feloran or voltarol or Voltaren or Cataflam or Voltaren-XR or Zipsor).mp. 10 (Aceclofenac or Hifenac or Cincofen or Nacsiv or Acenac).mp. (Ketorolac or toradol or torolac or kealc or kenalfin or 11 ketlac).mp. 12 (Apazon* or Azapropazon* or cinnopropazon*).mp. 13 (Aspirin* or acetylsal or dispril or easprin* or salicylic*).mp. (Ibuprofen or brufen or nuprin or rufen or salprofen or dolgit 14 or salprofen or advil* or motrin or nurofen or actiprofen or addaprin or aktren or anadin or bugesic or ibuprox).mp. (ketoprofen or orudis or oruvail or ketoflam or oruvail or 15 fastum or ketonal or ketodol or knavon or actron or ketoprofeno).mp. (Dexketoprofen or keral or enantyum or ketesgel or 16 dolmen).mp. 17 (Naproxen or naprosyn or naprosin or proxen or synflex or Aleve or Anaprox or Apronax or Naprelan).mp. (etodolac or ramodar or ultradol or etova or dualgan or etodin 18 or etopan or flancox or proxym or etodine or dolarit).mp. (Indomethacin* or indocid or indocin or indomet or 19 indometacin or metindol or osmosin).mp. 20 (Piroxicam or feldene or dolocare or dolonex or ketolin).mp. 21 (Meloxicam or mobic or vivlodex).mp. 22 (Tenoxicam or mobiflex).mp. 23 (celecoxib or celebrex or celebra).mp. 24 (rofecoxib or vioxx or ceoxx or ceeoxx).mp. 25 (valdecoxib or bextra).mp. (Nimesulid* or aulin or mesulid or nimalox or sulid* or 26 sintalgin or nimsid* or nise or nimulid).mp. 27 (Meclofenamic or meclofenamat* or meclomen).mp. 28 (fenoprofen or fenopron).mp. (oxaprozin or oxaprozinum or daypro or dayrun or 29 duraprox).mp. 30 (sulindac or cinoril or imbaral).mp. 31 (tolmetin or tolectin).mp. (flurbiprofen* or sulindac* or mesalazin* or sulfasalazin* or flufenamic* or tolmetin* or fenoprofen* or diflunisal* or niflumic* or ketorolac or trometamol* or parecoxib* or 32 teriflunomid* or benoxaprofen* or suprofen* or fenbufen* or mebron* or mepirizole* or mepyrizole* or methopyrimazole* or Epirizolum* or Polihexanid* or Dalex* or Miton* or epirizol* or clonixin* or tolemetin* or nabumeton*).mp. 33 or/6-32 NSAIDS exp opiate/ or exp narcotic agent/ or exp opiate 34 agonist/ exp hydrocodone/ or exp dextropropoxyphene/ or exp 35 fentanyl/ or exp / or exp methadone/ or exp oxymorphone/ or exp pentazocine/ or exp tramadol/ 36 opioid*.mp. 37 exp alfentanil/ or alfentanil*.mp. 38 exp codeine/ or codein*.mp. 39 (hydrocodon* or vicodin* or norco or lortab or zohydro).mp. 40 exp oxycodone/ or oxycodon*.mp. (dextropropoxyphen* or darvon or darvocet or digesic or 41 capadex).mp. 42 exp dihydromorphine/ or dihydromorphin*.mp. (fentanyl or actiq or duragesic or fentora or sublimaz* or 43 fenta).mp. 44 (meperidin* or demerol or pethidin*).mp. 45 (methadon* or dolophin* or methadose or amidon* or symoron or physephton* or heptadon).mp. 46 exp morphine/ or exp morphine derivative/ 47 (morphin* or oramorph or morphia or duramorph or contin or mscontin or sevredol or zomorphzomo).mp. 48 (oxymorphon* or numorphan or opana or morphon).mp. (pentazocin* or fortal or sosegon or talwin or fortwin or 49 talacen).mp. 50 (tramadol or ultram).mp. 51 or/34-50 Opioids 52 exp paracetamol/ (abenol* or acamol* or acenol* or acephen* or acet suppositories* or acetalgin* or acetamino phenol* or acetaminophen* or acetaminophene* or acetaminophenol* or acetamol* or acetomenophen* or acetylaminophenol* or adorem* or afebrin* or algiafin* or algotropyl* or alphagesic* or alvedon* or amadil* or anacin 3* or anaflon* or analgiser* or apamide* or apirex* or arthralgen* or benuron* or biogesic* or calapol* or calodol* or dafalgan* or depyretin* or 53 dirox* or dolex* or dolofen* or dolomol* or calpol* or eneril* or meforagesic* or dolorol* or metagesic* or napamol* or naprex* or pacemol* or pacimol* or duorol* or pamol* or panadol* or panamax* or panodil* or paracet* or paracetamole* or parageniol* or paragin* or paralen* or paralief* or paramax* or paramidol* or paximol* or paratabs* or perfalgan* or pyrigesic* or setamol* or tylenol* or tylex* or valadol* or winadol* or zydinol).mp. 54 or/52-53 Paracetamol 55 5 and 33 and 51 NSAIDS Vs Opioids NSAIDS Vs 56 5 and 33 and 54 Paracetamol (random$ or placebo$ or single blind$ or double blind$ or 57 triple blind$).ti,ab. 58 RETRACTED ARTICLE/ 59 or/57-58 RCTs 60 (animal$ not human$).sh,hw. 61 (book or conference paper or editorial or letter or review).pt. not exp randomized controlled trial/ (random sampl$ or random digit$ or random effect$ or 62 random survey or random regression).ti,ab. not exp randomized controlled trial/ non-human subject 63 or/60-62 or non RCTs 64 59 not 63 Human subject RCTs NSAIDS Vs Opioids 65 +Human subject 55 and 64 RCTs NSAIDS Vs Paracetamol 66 +Human subject 56 and 64 RCTs NSAIDS (Opioids or 67 paracetamol) in 65 or 66 human subject RCTs