11 22 33 44 55 Aa

bip_pgc3.6.chr3

20 1 0.8 0.6 0.4 0.2 0.1 1 . rs9834970 : Bipolar_disorder(22182935)(1E−12) snp / p / or / maf / info / directions Schizophrenia_o...(24280982)(1E−10)1 a a . rs9834970 / 6.63e−19 / 1.09 / 0.48 / 0.992 / 13−44−0 Bipolar_disorder(28072414)(2E−10)

● Bipolar_disorder(27329760)(5E−10)●●● ●● ●● Bipolar_disorder(28115744)(2E−9) 15 40 2 . rs3732386 : ●● Schizophrenia(28991256)(3E−11) ●● ● 3 . rs6550435 : Bipolar_disorder(24618891)(2E−8)●● ●● ● ● ● ● ● ● ●● ●● 4 . rs75968099 : Schizophrenia(25056061)(1E−13) ● ●● ●● Schizophrenia(26198764)(2E−12) ●● ● ● ● ●● 10 Autism_spectrum...(28540026)(1E−11)●● ● ● ● ●● ●●● ●● ●● ●● ●● ● ● ● ● ●● ● ● ● 5 . rs6789885 : Platelet_distri...(27863252)(2E−10)● ●● ●●●● 2 ● ●● 32 ● ● ●● ●● 3 ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 4● ●● ● ● p = 5.0e−08 ●● ● ●● ● ● ● ● ●● 20 ●● ● ● ● ●● ●● Observed (−logP) ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ●● ●● ● ●● ● ● ● ●●●● ●● ● ● ●● ● ●

● ●● ● ● ● 5 ● ●● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ● ● ● ● ●● ● ● 5● ● ● ● ● ● ● 5 ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●●● ●● ● ● ● ●● ●●● ● ● ● ●●● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●● ● ● ● ●● ● ●● ● ● ● ●● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●●●● ●● ● ● ●●● ●● ●●● ● ● ● ●●● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ●●●● ● ●● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ●● ●● ● ● ● ● ● ●● ●● ● ●● ● ● ● ● ● ● ● ● ●● ●●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ●● ●●● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●●●●●● ● ● ● ● ● ●●● ● ● ● ● ● ● ●● ● ●● ●●● ● ● ●●●● ● ● ● ●●●●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ● ●● ● ● ● ●●●●● ●● ● ● ●● ●● ● ●●●●● ● ●●● ●● ● ●● ●●●●●●●●●●● ● ●●●●●●●●● ●● ●● ● ● ● ● ●● ●●●●● ●● ●● ● ● ● ● ●● ● ● ● ● ● ●●●●● ● ● ●●● ●● ● ● ● ●● ●●● ● ● ●● ●●● ●●●●●●●●●●●● ●●●●●● ● ●●● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ●● ●● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●●●● ●●●●● ● ● ● ●● ●●● ● ● ● ●● ● ● ●● ● ●●● ● ● ●●●●●● ●●● ● ● ● ●●● ● ● ● ● ●● ● ● ● ● ●● ● ●● ●●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ●●● ●● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ●●● ●● ● ● ●●● ●●●●● ●●● ● ●● ● ● ● ● ● ●● ● ● ● ● ●●●● ● ● ● ● ● ● ●●●● ●●●● ● ● ●●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●●● ●●●●●● ●●● ●●●●● ●●● ● ● ● ● ● ● ●●● ●● ● ● ●● ● ●● ● ●● ● ●●● ● ● ●● ● ● ● ● ● ● ●● ● ●●●●● ● ●● ●●●● ● ●● ● ● ● 0 0 (cM/Mb) Recombination rate LINC02033 LOC152048

TRANK1 GOLGA4

EPM2AIP1

MLH1

LRRFIP2

36800 36900 37100 37300 Chromosome 3 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.17.chr6

16 1 0.8 0.6 0.4 0.2 0.1 1 . rs12202969 : Bipolar_disorder(24618891)(1E−8) snp / p / or / maf / info / directions ●●●●● ● ●● 2 . rs12206087 : Intelligence(7E−39) 12a a . rs1487445 / 1.48e−15 / 1.08 / 0.49 / 1.000 / 44−13−0 14 Cognitive_ability(29186694)(2E−11) ● ●●●● 3 . rs1487441 : Educational_attainment(25201988)(2E−9) 43 ●● ●●● ●● ● ● ●● ● Bipolar_disorder(27329760)(3E−8) ●5 12 6 ●● 4 . rs9401593 : Educational_att...(27225129)(4E−28) 40

5 . rs10457441 : Cognitive_function(25644384)(4E−9) ● ● ●● ●● 10 7●● 6 . rs1906252 : Educational_attainment(27046643)(1E−9) 8 7 . rs17814604 : Intelligence(3E−14)

Cognitive_ability(2E−11) p = 5.0e−08 ●● 8 ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●●●● ● ● ● ●● ● ● 8 . rs6931604 : Intelligence(4E−17) ● ● ●● ●●●●●●●●● ● ● ●● ● ● 9● ● 10 9 ● ● ● 10● ●●● 1111 ● ● 12 ● ● 9 . rs4587178 : Intelligence(8E−14) 12 ● ●●● 1313 ● ● ●● ●●

● ● 6 ● ● ● ● ● ● 14 10 . rs901630 : Intelligence(1E−28) ●●● ● 14 ●● 20

Observed (−logP) ● ● ● ●●● ●● ● ●● ●● ● ●● ● ● ●● ● ● ● ●● ● ● ●●●● ●●●● ●●●● ●●● ●● ● ● ●●● ● ●●●●●● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●●● ●●●● ● ● ● ●●● ● ● ● ● ● ●●●●● ●●● ●● ● ● ●●● ● ● ●● ● ●● ●●● ●● ●●● ● ● ● ● ...... ●● ●●●●●●●● ● ● ● ● ● ●●● ●● ●●● ● ●● ● ● ● ●●●● ● ●●● 15 ● ● ● ● ● ● ● ● ● ●●●●●●●●●●●● ●● 15 ● ● ● ●● ●●●●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ●●● ●● ● ● ● 4 ● ●● ● ● ● ● ● ● ● ● ● ● ●● 17●● 1616 ● ● 17 ● ●●●●● ●●● ● ● ● ● ● ●● ●●●● ● ● ● ● ● ● ● ●●●● ● ● ● ● ●●●● ●● ● ● ● ●●● ● ● ● ● ● ●● ● ●● ● ●● ●● ●● ●● ● ● ● ● ● ● ●● ●● ● ● ● 18 ● ● ● ●● ● ● ● ● ● 1919 18 ●● ●●●●●●● ● ●● ● ● ● ● ● ● ● 20 ● ● ● ● 21 ● ●● 22 ● ● ● ● ● ● 20 ● ● ● ● ●● ● ● 21 ● ● ● 22● ●●● ● ●● ● ● ● ● ●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ●●●●● ● ● ● ● ● ●● ●● ● ● ● ●●● ● ● ●●● ● ● ● ● ● ● ● ●●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ●●● ●● ● ● ● ● ●● ●● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ●● ● ● ● ●●●●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●● ● ● ●● ● ● ● ● ● ● ● ● ● ●●●●● ● ●●●● ● ● ● ● ●●●● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●●● ● ● ● ● ● 23 ●●● ●● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● 24● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 23 ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● 24 ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 25 ● ● ● ● ● ●●● ● ● ●● ● ● ● ● ● ● 26●●● ● ● ●● ●● ● ●● ●●●● ● ● ●● ● ● ● ● ● ●●● ● 25 ● ● ● ● ● ● ● ● 2 ● ● ● ●● ● ●● 26 ● ● ●● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ●●●● ●●● ● ● ● ●● ● ● ●●●● ● ● ● ● ● ●● ● ● ● ● ●● ●● ● ●●●● ●●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ●● ● ● ●● ● ● ● ●● ● ● ● ● ●●●●●●● ●● ●●● ● ● ● ● ● ● ● ● ●●● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 27 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 28 ● ● ● ● ● ● ● ● ● 27 ● ●●●●● ● ● ● ● ● ● ● ●●● ● ● ● 29● 28● ● ● ● ● ● ● ● ● ● ● ● 29 30 ● 30● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●● ● ● ●● ● ● ● ● ● ● ●●●● ● ● ● ●● ●●●●●● ● 31 ●● ● ● ●●●●● ● ● ●● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● 31● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ●● ●● ● ● ● ● ●● ● ●● ● ●● ● ● ● ● ● ● ●●●● ●●● ● ●●●●●●●●● ●● ●● ●●● ● ●●● ● ●●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ●● ●● ●●●●●● ● ●●●●● ● 32● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●● ● 33 ● ● ● ● ● ● ●●●●●●●●● ● ● ●●● ● ● 32● ● ● ● ● ●●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 33 ● ●● ●● ● ●● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ●● 34●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ●●●● ● ● 0 353534 0 (cM/Mb) Recombination rate MIR2113

98200 98300 98500 98700 98800 Chromosome 6 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.41.chr12

16 1 0.8 0.6 0.4 0.2 0.1 1 . rs2159100 : Schizophrenia(28991256)(3E−19) snp / p / or / maf / info / directions

●●●● ● ● ●●● 2 . rs1006737 : Schizophrenia_o...(24280982)(6E−13)●● 1 a a . rs11062170 / 1.87e−15 / 1.08 / 0.33 / 1.000 / 45−12−0 21 ● ● 2 ● ● ●● ● ●● ● ● ● ●● ● ●● ● ● ● ● ● ● ●●● ● ● ● 14 ● ● ● ●● ● Schizophrenia(23974872)(5E−12) ●●●●● ● ● ● ● ●●● ● ● ●●● ●●● ●●●● ●● ● ● ●● ● ● ●●●●●●●●● ●● ●● ●●● ● 3 ●● ● Autism_spectrum...(23453885)(5E−9) ● ●● ●● ● ● ●● ●● ●● ● ● Bipolar_disorde...(20351715)(3E−8)●● ● 12 ● ●● ●● ● ●● ● ● 40 3 . rs1024582 : Autism_spectrum...(28540026)(8E−14)●● ● ●● ● ● ● ● ● ● ● ●●4 ● ● ● 4● ●● ● ● ● ● ●● ●● ● ● ● ● ●● ●● ● 4 . rs2007044 : Schizophrenia(25056061)(3E−18) ● ● ● ●● ●● ●● 10 Schizophrenia(26198764)(1E−17) 5 ● ●● ● ● ● ●● Autism_spectrum...(28540026)(6E−14) ●● ●● 5 . rs4765913 : Bipolar_disorder(28072414)(3E−9) ●● p = 5.0e−08 8 ●● Bipolar_disorder(21926972)(2E−8) ●● 6 20

Observed (−logP) ●

● ● ● ●●● ●●● ● 4 ●● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ●● ● ● ●●● ●● ● ●● ● ● ● ● 2 ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ●●● ●●●●●●●● ● ●●●●●● ● ● ● ● ●● ● ●● ● ● ● ● ● ●● ●● ●●●●●●●● ● ●● ●● ●● ●●●●●●●●●●●●●●●●●●●●●●●●●● ●● ●● ● ●● ● ● ● ● ●●● ● ● ● ●●● ● ● ●● ●●● ●● ● ●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●●●●●● ● ● ● ● ●● ● ●● ●●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ●●●●●● ● ● ●● ● ●● ● ● ● ● ●●●●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ●● ● ●● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ●●●●●● ● ●●●●●●●● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ●●● ●●●●●●●● ●● ●● ●● ● ● ● ● ● ● ●●● ● ● ● ● ●● ● ● ●● ●●● ● ●●● ●● ● ● ●● ● ● ●●●●● 0 0 (cM/Mb) Recombination rate CACNA1C

CACNA1C−AS4

CACNA1C−IT3

2300 2400 2500 Chromosome 12 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.16.chr6

1 0.8 0.6 0.4 0.2 0.1 16 1 . rs13195401 : Breast_cancer(29059683)(2E−9) snp / p / or / maf / info / directions 2 . rs66975207 : Depression(7E−9) ●● a . rs13195402 / 5.75e−15 / 0.87 / 0.08 / 0.985 / 13−41−3 ● ● a ● ● 3 . rs13220495 : Squamous_cell_l...(28604730)(3E−8)● ● a ●● ● 1● ● ● 14 ● ● ● ● ● ● ● ● ● ● 1 ● ● ●●● ● ●●●● 2●● ●●●● ● ●● 4 . rs80264589 : Intelligence(8E−14) 3 2 ●●●● ●●●●●●● ●● 5 4 ● ●● ●● 3 ● ● ●● ●● ● ● 6 ● ● ●● ●● 7●● ● ● ●●● 5 4 8 ●● ● ●● 6 ●● ●7● ●●●● 9 ● ●● 10 ● ● 8 ● ● ●●● 11 ● ● ● ●●●●● ● 109 ● ● ● ● 11● ● ● ● ● ● ● ● ● ● ● Lung_cancer(28604730)(1E−8) ● ●●● ● ● ● ● ● ● ● ● ●● ● ●●● ● ●● ● 12 ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● 13● ● ● ● ● ●● ● ● ● 14 ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● 12 ● ● ● ●● 13 ● ● ●● ● ● ● ●●●●● ● ● ● ● ● ● ●● ●● 14● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ● ● ● ● 16 ● ● 15 ● ● ● ● ● ● ● ● ● ●●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● 12 ● ●● ● ● ● ● ● ● 16 15 ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●● ● ●● ●● ● ● ● ● ● ● ● ● ●●● ●●● ●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 5 . rs75782365 : Autism_spectrum...(28540026)(8E−24)●● ● ●● ● ● 17 ●●●● ● ●●● ●●● ●●● ●●● ●●●●● ●● ● ● ● ●● ● ● ●● ● 18 ● ● ● ● ●●● ● 19 20 ● ● ● ● ● 17● ● ● 21 ● ● ● ● ● ● ● ● ● ● 25 23 ● 22 ● ● 26 ● 24 ● 18 ●●28 27 ● ● ● 29 ● ● 20 ● 30 19 21 ● ● ● ●● ●●● 23 ● ● ● 31 ● ● ● 32 ● 2526 ●●● 22 3334 3524 ● ● ● 36 ● 27 ● ●● ● ● 28 ● ● ● 29 ● ● ● ● 37 30 38 ● 20 39 ● ● ● ● ●●● ● ●● ● ● ● ●● ●● ● ●● ● ● ● ● ● ● 31 ● ●● 32 ● 33 ● ● ● ● 34 ● 35 ● 40 ● ●●● ● 36 ● ● ● ● ●● ● ● ● ● ●37 ● ●●● ● 38 ● ●● ● 39 ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ●● ●●● Depression(6E−9) ● 41 ●● ●●●● ● ● 43 42 ●● ●● ●● ● ● ● ●●●●●● ● ● ● ● ● ● 44 40 ● ●● ● 46 45 ●●● ● ● ● ● ● ●●● ● ● ● ●● ● 47 ● ● ●●●● ● ● ● ● ● ● 48 ● ●●● ● ●● ● ● ● ● ● ● ● ● 41 ● ● ● 43 49 ●●● ● 42 ● ● ● 44 ●● ●●●●● ● ● 50 46 45 ● ●●● ● ● ● ● ●●●● ● 47 ●●●● ● ● ● 48 ●●●●●●●●●● ● ● 49 ●●●●●● ●●● ● ● ● ● ● 50 ● ● ● ●● 5152 ● ●● ●●● ●● ● ● ● ● ● ●● ● ● ● 53 ● ● ● ● ● ● ● ● ● ● ●● ● 51 ● ● ● 54 ● ● ● 52 ●● 55 ● ● ●●● ● ● 56 ● ● ● ● ● ● 53 ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● 54 ● ● ● 55 ● 6 . rs41266839 : Schizophrenia(26198764)(7E−27)● ● ● ● 57 ● ● ● ● ● 56 ●● ● ● ● ● ● ● 58 ●● ● ● ● ● ● 59 ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ●● ●● ●● ● ● ● ●● ● ● 57 10 ● ● 61 ● ● ● 60 ● ● 62 ● ● ● 58 ● ● ● ● ● 59 ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ●● ● ● ● ●● ●● 63 ● ● ● ● ● ● ● ●● ●● 60 61 ● ● ● ● ● ● ● 62 ● ●●● ●● ● ● ● 64● ● ● ●● ● 65 ●●● ● ●● ● ● ● ● ● ● 63 ● ● ● ●● ● ●● 64 ●● ● ● ● ● ● ● ●● ● ● 65 ●● ● ●● ● ●● ●●●● ●● ●●● ● ● ● ●● ● ● ● ● ● ● ●66 Lung_cancer(28604730)(4E−9)● ● 67● ●●● ● 68 ● ●●● ● ● ● 69 ●● ●● 66● ● ● ● 67● ● ● ● ● ● 68 ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● 69 p = 5.0e−08 ● ● 70 ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ●● ● ● ● ● 71 ● ● ● ● ● ● ● ● ● ●● 72 ● ● ● ●● ● ● ● ● ● ● 70 ●● 73 ● ● ●● ● ● ● ● 71 ● 72 ● ● ● ● ● ● ● ● 75 ●● ● ● ● ● 74 ● 73● ● 7 . rs17693963 : Schizophrenia(22688191)(3E−11)● ● ●● ●● ●● ●● ● ● ● ● ● ● 75 ● 74 76 ● ● ●● ● ● 77 ● ● ● ● ● ● ● ●●● 76 ● ● ● ● 77 ●●● 80 7879 ● ● ● ● ● ● ● ●● ● 81● ● ● ● ● ● 82 ● 78 ● ● ● ● 807983 ● ● ● 81 ● ● ● 8 ● ● ● 82 ● ● ● ● ● ● ●● ● ● ● ● ● 83 ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● Schizophrenia_o...(24280982)(3E−11)84● ● ● ● ● 85 ●● ● ●● ● ● ● ● ● ● ●●● ● ●● ● ● ● ● ●● ● ● ● ● ●●●● 84 ● ● ● ● ● 85 ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ● ●●●●● ●●●● ● ● ●●●● ● ● ● ● ● ● ● ●●●●●●●●● ● ● ● ●●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●●● ● ●● ●●● ● ● ●● ● ● ● ●● ●● ●● ● ● ●●●●●●● ● ● ● ● ●●● ●●● ● ● ●●●●● ● ● ●● ●●●●● ● ● ●●● ●● ● ● 86 ● ●●●●●● ● ● 87● ●● ● 88 ● ● ● 89 ● ● ●● ● 90● ● ● ● 91 ● ● ● ● ● ●● ●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ●●● ●● ● ● ● ● ● ● ● ● 86 ● ● ● ● 87 ● ● ● ● 88 ●● ● ● ● 89● ● ● ● ● ● ● ● ● ● ● ● 90 ● 91 ● ● ● ● ● ● ● ●● ● ● ● ● ● ● 92 ●●● ● ● ● ● ●● ●●●● ●●● 93 Schizophrenia,_...(24166486)(2E−9) ● ●● ● ● ● ● ● ● ● ● ● ● 94 ● ● ● ● ● ●●● ● ● ● ● ●● ●● ● ● 92 ● ● 93 ●●● ● ● ●● ● ● ● ● ● ● ● ●●● ● ●●● ● ●●● ●● ● 94 ● ● ● ● ● ● ●● ●● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ●●● ●●●● ●●● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ●● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●●● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ●●● ● ● ● ● 95 ●● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ●● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 96 ●● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 95 ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ●● ● ● ● Schizophrenia_o...(24280982)(3E−9)● ● ● ●●● ●●● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ●● ● ●● ●● ●● ●● ● ● ● ● ●● ● ●●●●● ● ● ● ● ●● ● ● ● ● 96 ● ● ● ● ● ● ●● ● ●● ●● ● ● ● ● ● ● ● ●● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ●● ● ●●● ●●●● ● ● ● ● ● ● ● ● 6 ● ● ●●● ● ● ● ● ●●● ● ● ● ●● ● ● ● ●●●● ● ●● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ●● ● ●●●● ●● ● ●● ●●● ● ● ● ● ●●●●● ● ● ● ●● ●97 ● ● ● ● ● ● ● ● 98●●● ●● ● ● ●● ● ● ● ● 97● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● 99 ● ●● ● 98● ● ● ● ● ● ●●● ● ● ●● ● 100 ● ● ●●● ● ● 101 ● ● ● ●● ● ●● ● 99 ●● ● ● ● ● ● ● ● ●●●● ●● ● ● ●● ● ● ● ● ●●● 102 ● ● ● ● ● ● ● ● 8 . rs55834529 : Schizophrenia(26198764)(9E−27) ● ● 103 ● ● ●● ● ● ● ● ●● ● 104 ● ●● ● ● ● ● ● ● ● ●● ● ● ●● ●● ● ● ● ● ● ●●● ● ● ● ● ● ●●● ● ● ● ●●● ● 100 ● ● ●● ● ● ● ● ● ● ●●●● ● ● ●●●● ● ● ● ● ● 101 ● ● ● ● ● ● ● 105 ●● ● ●● ●● ● ● ● ● ● ● ● ● ● 106●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● 102 ● ●● 107● ● ● ● ● ● ● ●● ● ●●● ● ● 103 ● ●● 104 ● ● ● ● ●● ● ● ●● ● ● ● ●● ●●●● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ●● ● ● ● ● 105 ● ● ● ● ● ● ● ●● ●● ●● ●● ●106 ● ● ●● ●● ● ●● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● 107 ●●●● ● ●● ● ● 108 ● ●● ●● ●●● ● ● ● ● ● ● ●● ●● ● ● 109 ● 110 ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ●●●● ● ● ●●● ● ●● ● ● ● ● ● ● ● ● ● ●●● ● ●● ● ● ● ●● ● ● ● ● 111●● ● ●●● ● ● ● ● ● ● ● ● ● 108 ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● 109 113 ● ● ● ● ● ● ● 110 112● ● ● ● ●●● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● 111 ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ●●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ●● 113 ● ● ● ● ● ●●● 112 ● ● ● ● ● ● 114 ● ● ● ● ●● ● ● ● ●●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● Breast_cancer(29059683)(3E−9)●● ● ● ● ● ● ● ● ● ●●●●● ● ● ●●●● ●● ●● ● ● ● ●● ● ● ● ● ● ● 115● ● ● ● ● ● ● ●● ● ●●● ● ● ● ● 116●●● ● 114 ● ● ● ● ●● ● ● ●●● 117● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ●● ● ●● ● ● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● 115 ● ● ●● ● ● ● ● ● ● ● ● ● 116● ● ● ● ●● ●● ● ● ●● ● ● ● 117● ●● ●● ●● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ●●● ● ● ●●● ● ● ● ● ● ● ● ● 118 ● ● ● ● ●● ● ● ●● ● ● ●● ● ● ● ● ●●● ● ● 119 ●● ● ●● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ●● ● ● ●●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ●120● ● ● ● ● ● ● ● ● ● ● ● ● ● ●118 ● ● ● ● ● ● ● ●● 121● ● ●● ● 123● ● ● ● ● ● ●● ● ● 122 ● ● ● 4 ● ● ● ● 119 ● ● ● ●● ● ● ●● ● ● ● ●● 124 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ●●●●● ● ● ● ● ● ● ●● ● ● ●● ●● ● ● ● ● ● ●●● ●● ●● ● ● ● ● ● ● 120 ● ● ● 125 ● ● ●● ● ● ● ● ● ● ● ● ● 121 ● ● ● ●●● ● ● 126 ● ● ● 123 ● ● ● ●● ● ●● 122 ● ● ● 124 ● ● ● ● ● ●● ●● ● ● ● ● ● ● ●● ● ● Depression(3E−9)●● ● ● 125● ● ●●● 127 126 ● ●●● 127130129130129● ● 131 ● ● ●● ●128128 Observed (−logP) 131 132 ● 133 ● 133 ● 132 134 ● ● ● 9 . rs66488313 : Lung_cancer(28604730)(2E−8)137136135 ● 134 136135 137 ● 138 139 ● 138 139 140140 141141● ● 142 filter: p < 0.001 ● 143 ● 144 ● 142 145● 143● 10 . rs13201782 : Squamous_cell_l...(28604730)(2E−8)144 ● ● 146 ● ● 145 ● 147 ● 2 ● ● ● ●● ●● ● ● 148 147146 ● ● 149 148 ● 150 ● ● ●● 149 ● ● 150 ...... 151 152● ●153● ● 151154 ● 152 156153 155 ● 157 158 ● 159160 ● 161 ● 154● 165 163164162 ● 166 156 155 ● ● 157 ● 167 158161 ● 159160● ● ● ● ● ● 168 163164162● 169 165 ● 166 ● ● 167 ●171 170172173 ● 0 196196195180195180194194189189191191171197197183179183179181181170168190192172173185190192186184185186174184174182182198198199200199177177 188188187187175175176176 169193193 178178 0 CMAHP HIST1H3C200HIST1H1D ABT1 GUSBP2 LINC01012 OR2B6 GPX5 LINC01623 OR10C1

LOC101928663 HIST1H1C HIST1H4F ZNF322 LINC00240 LOC100131289 OR1F12 ZBED9 HCG14 OR2H1

CARMIL1 LOC108783645HIST1H4G LOC100270746 HIST1H2BL ZNF165 LINC00533 TRIM27 MAS1L

SCGN HFE HIST1H3F HIST1H2BJ HIST1H2AI ZSCAN12P1 LINC01556 LINC01015

HIST1H2AA HIST1H4C HIST1H2BH HIST1H2AG HIST1H3H ZSCAN16−AS1 HCG15

HIST1H2BA HIST1H1T HIST1H3G HIST1H2BK HIST1H2AJ ZSCAN16 ZNF311

HIST1H2APS1 HIST1H2BC HIST1H2BI HIST1H4I HIST1H2BM ZKSCAN8 LOC100129636

SLC17A4 HIST1H2AC HIST1H4H HIST1H2AH HIST1H4J ZNF192P1 OR2W1

SLC17A1 HIST1H1E BTN3A2 MIR3143 HIST1H4K TOB2P1 OR2B3

SLC17A3 HIST1H2BD BTN2A2 PRSS16 HIST1H2AK ZSCAN9 OR2J1 Recombination rate (cM/Mb) Recombination rate

SLC17A2 HIST1H2BE BTN3A1 POM121L2 HIST1H2BN ZKSCAN4 OR2J3

TRIM38 HIST1H4D BTN2A3P VN1R10P HIST1H2AL NKAPL OR2J2

HIST1H1A HIST1H3D BTN3A3 ZNF204P HIST1H1B ZSCAN26 LOC101929006

HIST1H3A HIST1H2AD BTN2A1 ZNF391 HIST1H3I PGBD1 OR14J1

HIST1H4A HIST1H2BF LOC285819 ZNF184 HIST1H4L ZSCAN31 OR5V1

HIST1H4B HIST1H4E BTN1A1 HIST1H3J ZKSCAN3 OR12D3

HIST1H3B HIST1H2BG HCG11 HIST1H2AM ZSCAN12 OR12D2

HIST1H2AB HIST1H2AE HMGN4 HIST1H2BO ZSCAN23 OR12D1

HIST1H2BB HIST1H3E LOC105374988 OR2B2 GPX6 OR11A1

25100 25800 27300 28800 29500 Chromosome 6 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.36.chr11

1 0.8 0.6 0.4 0.2 0.1 14 1 . rs174592 : Serum_metabolit...(29545352)(3E−13) snp / p / or / maf / info / directions 2 . rs174567 : Serum_metabolit...(29545352)(2E−13) a . rs174592 / 9.92e−14 / 1.07 / 0.40 / 0.987 / 12−45−0

3 . rs174601 : Red_blood_cell_...(25500335)(3E−305) 1 ●●a ● 1 ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● 2●● ● ● 3 2 ● ● Gondoic_acid(1E−45) ● 5 43 7 ● 6 ● 8 5 ●4 7 6● ● 9● 10 11 ● 8 ● 13●9 ● 1012 ● ● 12 ●● 12 1411● 13 ● ● ● ● ● ● 14 ● ● ● ● ● 151516●17 ●●●●● ● ●● Blood_metabolite_levels(24816252)(8E−16)161919242417 25 2121●● 2222232318182020 27 2628 ● 27 26252931292831●● 3030 ● ● 32 ● ● 32 34● ● ●● ● 33 34 ● 33 40 Trans_fatty_acid_levels(25646338)(3E−13) 35353737●● 3838● 3636 4040 3939●● Liver_enzyme_le...(22001757)(3E−9) 4141 10 ● ● ●● ● ● ● ● ● 42 ● ● ● 43 ● 4 . rs174594 : Colorectal_cancer(29471430)(2E−13)4544 42 43 ● ●● 44 ● 45 ●● ● ● ● ●● Serum_metabolit...(29545352)(5E−13) 8 p = 5.0e−08 Plateletcrit(27863252)(9E−10) ●●

●● Hemoglobin_A1c_levels(29403010)(4E−9)● ●● ●● ● ● ● ● ● ●● ● ●●● ● ● ●● ● ● ●● ● ●● 5 . rs174578 : Glycerophosphol...(26068415)(2E−43)● ● ● ● ● ● ● ●● ● ● ● ● ● ●● 46 ●● 6 ● 46 ● ● ● ●● 47 ● ● 47 ● 48 ● ● ● 48 ● ● Blood_metabolite_levels(24816252)(6E−42)● 49● ● ● 49 20 ● ● ● Observed (−logP) ●● 50 ● ● 50 ● Blood_metabolite_levels(24816252)(3E−24)● ●● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ●●● ● 51 ● ● ● ● ● ● ● 52525351 ● ●● 4 Glycerophosphol...(26068415)(3E−18) 53 ● ● 54 ● ● 54 ● ● ● ●● ● ● ● ● ● ● ● ● ● ●●● ● ●55 ●●● ● 55 ● ●●● ● ● ● ●● ● ● Serum_metabolit...(29545352)(9E−18) ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●●● ● ● ● ● ●● ● ●●● ●● ● ● ● ● ● ● 56 ● ● ● ● ● ● ● 56 ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ●● ● 57 ● ● ●● ● ● ● ● 57 ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● Plasma_omega−6_...(26584805)(2E−16)● ● ● ●● ●●●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●●● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● 58 ● ● ● ● 59● ● ● ● ● ● ● 58● ● ● ● ● ● ● ● 59● ● ● ● ● ● ● ● 2 ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●● ● ● ● ● ●● ● ● ●●● ● ● ● ● ● ● ● ● ● Trans_fatty_acid_levels(25646338)(5E−14)●●● ●● ●● ● ● ● ● ●●● ● ● ●● ● 60● ● ● ● ● ● 60 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● 6 . rs174581●● ● : Serum_metabolit...(29545352)(4E−25)● ● ●● ● ●●● ●●● ● ● ● ● ● ● ● ● ●●● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●● ●● ● ● ● ●●● ● ● ● ●● ● ● ●●● ● ● ●● ● ● ● ●● ● ● ● ● ●●●● ●● ●● ● 0 Serum_metabolit...(29545352)(3E−18)6161 0 (cM/Mb) Recombination rate DAGLASerum_metabolit...(29545352)(1E−15) FEN1 MIR6746 Serum_metabolit...(29545352)(4E−15)

Serum_metabolit...(29545352)(7E−15)MYRF FADS1 RAB3IL1 Serum_metabolit...(29545352)(3E−12) 7 . rs174528 : Plasma_omega−6_...(26584805)(2E−65)DKFZP434K028 MIR1908 Gondoic_acid(3E−46) TMEM258 FADS2 Serum_metabolit...(29545352)(5E−18) Serum_metabolit...(29545352)(8E−15) MIR611 FADS3 Serum_metabolit...(29545352)(9E−14) Serum_metabolit...(29545352)(4E−13) Trans_fatty_acid_levels(25646338)(4E−12) Vaccenic_acid(7E−10)61500 61600 61700 8 . rs99780 : Serum_metabolit...(29545352)(2E−16) 9 . rs102275 : Metabolite_levels(22916037)(4E−264) Chromosome 11 (kb) Phospholipid_le...(22359512)(1E−203) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.21.chr7

14 1 0.8 0.6 0.4 0.2 0.1 1 . rs113779084 : Educational_att...(27225129)(3E−8) snp / p / or / maf / info / directions 1 a a . rs113779084 / 1.42e−13 / 1.08 / 0.30 / 0.976 / 44−13−0 12

●● ●● ●● ●● ●● ● 40 10 ● ●● ●● ●● ●● ●●

●●

●● ●● 8 ●● ●● p = 5.0e−08 ● ●● ● ●● ● ● ● ● ●●

● ● ● ● ●●●● ●● ● ● ● ● ● ● ●● ●● ●●● 6 ●●

●● ● ●● ● ●● 20 ● ● Observed (−logP) ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ●● 4 ●● ● ● ●● ● ●● ● ● ● ●● ●●● ● ● ● ●●●●●●●●●●●● ● ● ● ●● ●● ●●●● ●● ● ● ● ● ● ●●●●●● ● ● ● ● ● ● ●● ● ● ●● ● ● ●● ● ● ● ● ●● ● ●● ●●●●● ● ● ●●● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ●●● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ●●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ●● ● ● ●● ● ● ● ● ● ●●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● 2 ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●●● ● ● ● ● ● ●●●● ● ●● ● ● ● ● ● ● ●●● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ●●●●● ● ●●● ●● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●●●● ●● ● ● ● ● ● ● ● ● ●●●●● ● ●●●●●●●●●●● ● ● ●● ● ● ● ●●●●● ● ● ● ●●● ● ● ● ● ● ●● ●●●●● ● ● ●● ●● ●●● ● ● ●●●●●● ● ●●● ● ● ● ● ● ● ● ● ●●●● ●● ●●●●● ●● ● ● ● ● ●●●●● ●● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ●● ●● ●●● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ●●● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ●● ●● ●●●●●● ●● ● ●● ●● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ●●● ●● ● ● ●● ●●●● ● ●● ● ● ● ● ●● ●● ● ● ● ●●● ● ● ● ● ●●● ●●●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ●● ● ●● ●●● ● ●●● ● ●●●● ● ● ●●● ● ●●●●● ●● ●●●● ● ●● ● ● ● ● ● ● ● ● ●● ●●●●●●●●● ● ● ●●●●●● ●●● ● ●●● ● ● ● ●●●● ● ● ● ● ● ● ● ●●●● ● ● ● ●● ● ● ● ● ●●● ● ●● ●● ●●●● ● ●●● ● ●● ● ● ● ●● ● ● ●● ● ● ●●●●●●●●● ● ● ●● ●● ● ● ●●● ● ●● ●● ● ● ● ● ●●● ● ● ● ● ●●●● ● ●● ● ● ● ● ●● ● ● ●● ● ● ●● ● ● ●●● ● ● ● ● ● ●●● ● ●●● ●● ●● ● ● ● ● ●● ● ● ● ●● ●●● ●●●●● ●● ● ●●●●●●●● ● 0 0 (cM/Mb) Recombination rate THSD7A

11800 11900 12000 Chromosome 7 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.7.chr3

14 1 0.8 0.6 0.4 0.2 0.1 1 . rs2590838 : Adiponectin_levels(22479202)(2E−13) snp / p / or / maf / info / directions Waist−to−hip_ra...(28448500)(2E−9) a . rs2336147 / 3.61e−13 / 1.07 / 0.50 / 0.999 / 45−12−0 ● ● ● ● ● ● ● ● ● ●● ● ● 12 a● ● ●● ●● ● Waist−to−hip_ra...(28448500)(2E−8) 123 4 12 ● ● ● ● ● ● ●● ●● ●●● ● ● ●●● ●● ●● ● 5 ● ● ● 2 . rs2577831 : Schizophrenia(28991256)(5E−13) 5 ●●●●● ● ● ● ● ●● ● ●● ● ● ● ●●●● ● ●6 ● 76 ● ● ● ● ● 7 ● ● ● ● 89 ● ● ● ● 89 ● ● ●● ● ● ● 3 . rs13083798 : Waist_circumfer...(28448500)(2E−11)● ● ●● ● ● ● ● ●● ● ● ●●● ● ● ● ●● ● ● ● ● ● 10 ● ● ● 11 ● ● 10 ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 11 ● ● ● ● ● ●●● ● ● ● ● ●● ●●● ● ● ● ● ● ● 40 ●● ● ● ● ● ●● ● ● ● ● ● ●● ●●●● ● ● ● ● ● Waist_circumfer...(28448500)(4E−11) ● ● ● ●● ● ● ● ● ●● ● ● ● ● ●●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● 10 ● ●● ● ● ●● ● ● ● ● ●● ● ● ●●● ● ●● ● ● ● ● ● ●● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●● ● ● 12 ● ● ●● 13 ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ●● ● ● ●●●●●● ●● ● ● ●● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● 12● ● ● ● ● 13● ●●●● ●● ●● ● ● ●● ● ● ● ● ●● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● 14 ●● ●●●●●● ●●● ● ●● ● ● ● ●●●● ● ●● ●● ● ●● ● ● ● ● ●● ● ● ● ● ●●●● ●● 14 ● ● ●●● ● ● 15 ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● 15 ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ●●●● ● ●● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●●●●●●● ● ● ● ● ● ● ● ● ● ●● ● ● ● 16● ● ● Waist−to−hip_ra...(25673412)(4E−11) ●● ● ●●● ● ● ●16● ● ● ● ● ● ●● ●●●● ● ● ● ● ●● ● ● ● ● ● 17 ● ● ● ● 18 ● ● ● ●● ● 17 ● ● ● ● ● ● ● ●● ● ● 18 ● ● ● ●● ● ● ● ● ● ● ● ● 19 ● 20 ● ● ● ● ●● ● 19 20 ● ● ● ● ● ● ● ●● ●●● ● ● ● Waist−to−hip_ra...(25673412)(7E−11) ● ● ● 21● ●● ●●● ● 21● ● ● ● ●● ● 22●● ●● ●● 2424 222323 8 Waist_circumfer...(28448500)(1E−10) 25 p = 5.0e−08 2626 25●● ●● ●● ● ●● ● ● ● ● ●● Waist_circumfer...(28448500)(5E−10) ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●● ● ● ● ● 27 ● ●● ● ● ●● 27 ● ● ● ●● ● ● ● ● ● ● ●● ● ● ●● ●●● ● ● ● ●●●●● ● ● ● ● 2928●● ● ● ●● 2928●●● ● ● ● ●● ● ● ● ●● ● ● ● ● Waist_circumfer...(28448500)(5E−10) ●●● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 30 ● ● ● ● ● ● ● ●● ● ● ● ● ● 30 ● ● ● ● ● ● 31 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 31 ● ●● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● 6 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● Waist−to−hip_ra...(25673412)(5E−10) ●●● ● ● ● ●● 32 ● ● ● ●● ● ● ● ● ●●● ●● ● ● ● ●● 32 ●● ●● ● ● ●●●● ● ●● ● ●● ●●● ● ● ● ● ●●● ●●●●● ● ●● ●● ● ● ● 33 Waist_circumfer...(28448500)(6E−10)● ● 33 20 ● ●

Observed (−logP) ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ● ●●● ● Waist−to−hip_ra...(25673412)(2E−9) ● ● ● ●● ●● ● ● ● ● ● ●●● ●● ●● ● ● ● ● ● ●●● 4 ● ●● ● 3434 ● ● ● ● ●● ●● ● Waist_circumfer...(28448500)(3E−9) ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●●● ● ●● ● ●●● ● ●● ● ●●● ●●●● ● ●● ●● ●●●● ● ● ● ● ● ● ●● ●● ● ● ●● ● ● ● ●● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●● ●● ●●● ● ● ● ● ● ● ● ●●●●●●● ● ● ● ●●● Waist_circumfer...(28448500)(4E−9)● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ●●●● ● ● ●●● ●● ● ●●●●●●● ● ● ●● ●● ● ●● ● ● ● ● ●● ●●●● ● ●●●●●●●● ● ● ● ●● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ●●● ● ●● ● ● ● ●● ● ● ● ●● ●●35●●●●●●●●● ●● ●●● ●●● ●●●●● ●●● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● 35●●●●●●●●●● ●● ● ● ● 36 ● ● Waist_circumfer...(28448500)(1E−8)● ● ● ● ● 36● ● ● ● ● ●●●● ● ●●● ● ● ● ●● ● ●●● ● 37● ●●●●●●●●● ● ● ● ● ● ● ● ● ● ●● ●●● ●● ● ●● ● ● ● 38● ● ●● ● ● ●● ● ● 37● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● 38 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● 39 ● ● ● ● 2 ● ● ●●● ●●●●●●●●● ●● 39● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ●●●● ● ● ● ● ● ● ● ●●● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ●●● ●●● ●● ● ● ● ● ● ● ● ● ● ●● ●● Waist−to−hip_ra...(28443625)(1E−8)● ●● ● ● ● ● ● ● ● ● ●●● ● ● ● ● 40● ● ● ● ●● ● ● ●● ● ● ● ● ● 40 ● ● ● ● ● ●● ● ● ● ●● ●● ● ●● ● ● ●● ● ●●● ● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ● ●●●● ● ● ● ● ●● ● ● ● ● ●● ●●●●●●●●●●●●● ● ● ●● ● ● ●● ●●●● ●●● ● ●●●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●41 ●●●●● ● ● ● ● ●●● ●● ● ● ● ● ● ● ● ● ● ● ●41 ●●● ● ● ● ● ● ● ●● ● ● ● ● ● ●●● ● ● ● ● ● ● ●●●●●●● ●●●●●●●●●●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●● ● ● ● ●●● ● ● ● ● ● ● 4342● ● ● ● ● ● ● ●● ● ● ● ● ● ● 44● ● ●● 4 ●●.● ●rs1108842●●●●●● ● : ● Adiponectin_levels(22479202)(1E−13)●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● 43● ● ● ● ● ● ● ● 42 ●●●●● ● ●●● ● ● ● ●● ● ● ● ● ● ● ● ● ● 44 ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ●● ●● ● ● ●● ●● ●● ● ●● ● ● ● ●●●● ● ●● ●● ● ● ●●● ● ●●●● ● ●●●● ●●● ●● ● ● ● ● 45● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ●● ●●●● ●●● ●● ● ●● ● ● ● ●45 ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●●● ● ● ● 4848●46464747

Intelligence(8E−9) (cM/Mb) Recombination rate 0 filter: p < 0.5 0 POC1A5 . rs2710323 : Waist−to−hip_ra...(26426971)(7E−12)MIRLET7G SEMA3G GNL3SPCS1 TMEM110−MUSTN1

ALAS1 Waist−to−hip_ra...(26426971)(6E−10)GLYCTK TNNC1 SNORD136 NEK4 STIMATE Waist−to−hip_ra...(28448500)(4E−9) TLR9 GLYCTK−AS1 NISCH SNORD19 ITIH1 MIR8064 Schizophrenia,_...(24166486)(3E−8) TWF2 Waist−to−hip_ra...(28448500)(4E−8)MIR135A1 STAB1 SNORD19B ITIH3 SFMBT1

6 . rs2535633 LOC101929054: Body_mass_index(24861553)(2E−10)DNAH1 NT5DC2 SNORD19C ITIH4 RFT1 7 . rs2535627 : Schizophrenia(26198764)(2E−11) PPM1M BAP1 SMIM4 SNORD69 ITIH4−AS1 PRKCD Schizophrenia(25056061)(4E−11) WDR82 PHF7 PBRM1 GLT8D1 MUSTN1 8 . rs2302417 : Bipolar_disorder(28072414)(3E−9) 9 . rs3617 : Autism_spectrum...(28540026)(3E−12) Red_blood_cell_count(27863252)(2E−9) 5220010 . rs1060330 :52300Waist−to−hip_ra...(26426971)(3E−8) 52700 53100 53200 ...... Chromosome 3 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.33.chr10

12 1 0.8 0.6 0.4 0.2 0.1 1 . rs10994415 : Bipolar_disorder(24618891)(7E−11) snp / p / or / maf / info / directions

● 2 . rs10994299 : Bipolar_disorder(28072414)(1E−9)●● ● a . rs109944151 ●a / 1.14e−11 / 1.13 / 0.08 / 0.999 / 11−44−2 ● ● 1 ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ●● ● 3 . rs10994397 : Autism_spectrum...(23453885)(7E−9) ●●● ● ●● ●● ● 10 ●●● ●● ●● ● 2 ● 4 . rs10994359 : Autism_spectrum...(23453885)(3E−9)2 ● 4 3 ● ● 4 ● ●● ● ● ● ● ●●● ●● ●● 5 . rs10994336 : Bipolar_disorder(18711365)(9E−9) 5 ●● 5 ● ● ●● ●● 6 . rs4948418 : Bipolar_disorder(22182935)(4E−10) 6 ●● 40 8 p = 5.0e−08

●● ●● ● ●● ●●

● ● ● 6 ●

● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ●● ●● ●● ● ● ● ● ● ● ● ●●● ●● ● ● ● ●● 20 ● ● ●● ● ● Observed (−logP) ● ● ●●●●●●● 4 ● ●● ●● ●● ● ●● ●● ●● ● ● ● ● ● ● ● ●●●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ●● ● ● ● ● ● ● ●●● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ●● ● ● ● ● ● ● 2 ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ●●●● ●● ● ●●●●● ●● ● ● ● ● ● ● ● ● ● ● ● ●●●●●●●●●●●●●●●●●●●●● ● ●●● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●●● ●●● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ●● ● ● ● ●●● ● ●● ● ●● ● ●● ● ●● ●●●●● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ●● ● ●● ● ● ●● ● ●●●● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ●● ● ●● ●● ● ● ●●●● ● ●● ●● ● ●● ●● ●●●●● ●● ●● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ●●●●●●●●●●●● ●●● ●●●●●●●●●●●● ● ●●●●● ●●●●● ● ● ● ● ●● ● ● ● ● ●●●● ●●● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ●● ● ● ● ● ● ● ●●● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●● ● ● ●●●● ● ●● ●● ● ●● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ●●● ● ● ●●● ● ● ●●● ● ● ● ●●●●● ● ●● ● ●● ● ● ● ● ● ●● ●● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ●●●● ●●●● ●●●●●●●●●●●● ●● ●● ● ● ● ● ● ● ●● ●● ●● ●●●●●●●●●●●●●●●● ●●● ● ●● ●● ● ● ●● ● ● ● ●● ● ●● ●●●●● ● ●● ● ● ● ● ● ● ● ●●● ● ●●●●●●●●●●●●●●●●●●●● ●●● ●●●●●●● ● ● ● ●●●●●● ● ● ● ● ●● ●●●●● ● ● ●● ● ●● ● ● ●●● ● ● ● ● ● ● ● ● ●●●●●●● ●●●● ●●●●●●●●● ●● ●●● ● ● ● ● ● ● ●● ●● ● ● ● ● ●●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ●●●● ●● ● ● ●●●●●●●●●● ● ● ● ● ● ● ●● ● ● ●● ●●●●●● ● ●● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●●● ●● ● ●●● ● ●●● ● ●● ●● ● ● ● ● ● ●●●●● ● ● ● ● ● ● ●● ●● ● ●●●● ● ● ● ● ●●● ●● ● ●● ●● ● ● ● ●●●●●●●●●●●●●●●● ●●●●●●●●●●●●●● ●●●●● ●●●●●●● 0 0 (cM/Mb) Recombination rate ANK3

62000 62200 62400 Chromosome 10 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.35.chr10

12 1 0.8 0.6 0.4 0.2 0.1 1 . rs17095355 : Biliary_atresia(20460270)(7E−9) snp / p / or / maf / info / directions 2 . rs10884920 : Bipolar_disorder(28072414)(3E−8) a . rs2273738 / 1.63e−11 / 1.10 / 0.14 / 0.936 / 42−15−0 ● a ● ● a ● ●● ●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● 3 . rs17127170 : Platelet_count(29403010)(4E−8) ● ● ● ● ● ● ● ● ●●● ●●●●●●●●●● ● ● ● ●●●● ●●●● ●● ●● ●●●●● ● ● ● ● ●● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●●●●● ● ● 10 ●● ● ● ● ● ● ● ●●● ● ● ●●● ● ● ● ● ●● ● ● ●● ● ● ●●● ● 4 . rs77652395 : White_blood_cell_count(29403010)(7E−10) ●● ● ● ●● ●● ● ● ● 1● ● ● ● ● ●● ● 1 ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ●● ● 2 ● ● ● Neutrophil_count(29403010)(4E−8) 2 ● ● ●● ● ● ●● ●● ● ●● 40 ● ●● ●● ●● ● ● 8 ● p = 5.0e−08

● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●● ●● ● ●● ●●●●●● ●● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ●●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●●● ●● ● ● ● ● ●● ●●●● ● ●● ● ●● ●● 6 ●● ●● ● ●● ● ●●

● ● ● ● ●● ●● ● ● ● ●● ●● ●● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● 20 ● Observed (−logP) ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●● ● ● ● ● 4 ●● ●● ● ● ●● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ●● ●● ● ● ●● ● ● ● ●●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●●● ●●●● ● ● ●● ●●●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ●●●● ● ● ●●●●● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ●● ● ● ● ●●● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ●● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ●●●● ●●●● ● ●●● ●● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●● ● ● ●● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ● ●● ● ● ● ● ●●●●●●●● ● ●● ● ● ● ● ● ● ●●● ● ● ● ● 2 ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●● ● ● ● ●●● ● ●● ●●● ● ● ● ● ● ● ●●● ●● ●●●●●●●●●● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ●●●●● 3 ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● 3 ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●● ● ● ● ● ● ● ● ● ●●● ● ● ●● ● ● ●● ● ● ●● ● ● ●● ● ●● ●● ● ● ● ● ● ● ● ● ● ● 4● ● ● ●● ● ●● ● ● ● ● 4 ●● ● ●● ● ● ● ● ●●●● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ●● ● ● ● ● ●●●●●●● ●●●●●●●●●●●●●●●●●●●●●●● ● ●●●●●●● ●●●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ●● ●● ● ● ● ● ● ●● ● ● ● ● ●●●●●●●●●● ●●●●● ●● ●● ● ● ● ● ● ● ●●● ● ●● ● ● ● ● ● ● ●●●●● ●●●●●● ●● ● ● ●●●● ● ● ●●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●●● ●● ● ● ● ● ● ● ● ● ●● ●●●● ● ● ● ●● ● ●● ● ● ● ● ●●● ●● ● ●●● ● ● ● ● ● ● ● ● ● ● ●●●●● ● ●●● ●● ●●● ● ● ● ● ● ●● ● ● ● ●● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●●●● ● ●●●● ● ● ●● ● ● ●●● ● ● ● ● ● ●●●● ● ●● ●●●●●●● ● ●● ● ●● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ●● ● ● ● ● ●● ●● ●●● ●●●●●●●●●●●●●● ● ● ● ● ● ● ●● ● ● ● ●● ● ●● ● ● ● ● ● ●●● ● ● ● ●● ●● ● 0 0 (cM/Mb) Recombination rate XPNPEP1

ADD3−AS1

ADD3

MXI1

SMNDC1

111500 111600 111800 112000 Chromosome 10 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.27.chr8

12 1 . rs12543645 : Schizophrenia(28991256)(3E−8) snp / p / or / maf / info / directions 2 . rs73191547 : Schizophrenia(26198764)(4E−8) a . rs62489493 / 2.64e−11 / 1.09 / 0.13 / 0.986 / 15−42−0 ● a 3 . rs11249992 : Systolic_blood_pressure(28739976)(4E−11) a b . rs3088186 / 2.08e−08 / 1.06 / 0.29 / 0.994 / 43−14−0 ● ● 10 ● ● ● 4 . rs615632 : Neuroticism(29255261)(3E−21) ● ● ● ● ● ● ● ● ● ● ● ● 5 . rs9329221 : Neuroticism(29255261)(9E−28) ● ● ● ● ● ● ●●●● ● ●●●● ● ● ●● ● ● ● ● ●●●● ● ● ●● ● ● ● ● ● 40 ● 6 . rs6601450 : Eosinophil_perc...(27863252)(2E−9) ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ●● ● ●● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● 8 Eosinophil_perc...(27863252)(3E−9) ● ●● ● p = 5.0e−08 ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ●● ● ●● b ● ● ● ● b ● ● ● ● ● 7 . rs2409797 : Neuroticism(29255261)(5E−30) ● ● ● ●● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● Barrett's_esophagus(27527254)(3E−9) ● ● ●● ● ●● ●● ● ● ● ●● ● 1 ●● ● ● 1 ●● ● ● ● ● ● ● ● 8 . rs10108511 : Barrett's_esoph...(27527254)(2E−9) ● ●● ● ● ● ● ● ● ● ●● ● ●●● 6 ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● 9 . rs12682352 : Neuroticism(29255261)(1E−24) ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● 2 ●● ● ● ●● 2● ● ● ● ● ● ● ● ● Neuroticism(27067015)(2E−15) ● ● ● ● ● 4 ● ● 3 ● ● 3 ● ● 4 ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 5 ● ● ● ● ● ● ● ● 5 ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● 10 . rs2929451● : Nose_size(27182965)(6E−11) ● ● ●● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● 20 ● ● ● ● ●●● ● ● ● ●● ●● ● ● ● ● ● ● ● ●● ● ●● ●● ● ● ● ● ● Observed (−logP) ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ●●●● ● ● ●● ● ● ● ●● ●●● ●● ● ● ● ●● ● ● ● 4 ● ● ●● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● 6●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● 7 6 ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● 7 ● ● ...... ● ● ●● ● ● ● ●● ●● ● ●●● ● ● ●● ● ●●● ● ● ● ●● ●● ● ● ● ● ●● ● 8● ●● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ●●● ● ● ● ●● ● ● ● ●● ● ●●● ● ● ● ●● 8●● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ●● ●● ● ● ● ●● ● ● ● ● ●● ●●●● ● ● ● ●● ● ●● ●● ● ● ● ● ● ●●● ● ● ● ●● ● ● ● ●● ● ● ●● ● ●●●● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ●● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ●●9●● ●● ●● ● ● ● ● ● ● ●●● ● ● ●● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ●● ●● ●● ● 10 ● ● ● ● ●● ●● ● ● ● ● ● ● ●● ● ● ● ● 11 ●● ● ● ● ●● ● ● ● ● 9● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ●● ● ● ●●● 13 ● ●● ● ● ● ●●● ● ● 12 ● ● ● ● ● ●● ● ● ● 10 ●● ● ● ● ● ● ●● ● ● ● ● 1114● ● ● ● ●● ● ●● ● ● ●● ● ● ● ● ●●15● ● ● ● ● ● ● ●●● ● ● ● ●● ● ● ● 13 ●● ● ●● ● ● ● ● ● ● ● 12 ● ● ● ● ● ● ● ● ● ● ●● ●● ● ●●● 14● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● 15● ● ● ● ● ● ● ● ● 16 ●●●● ●● ● ●●●● ● ● ● ●● ● ●● ● ● ●● ● ● ● ● ●●● ● ● ● ● ●● ●● ● ●● ●● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ●●● ● ●● ● ● ● ● ● ● ● 17 ●● ● ● ● ● ●● ● ● ● ● ●●●● ●● ● ●● ●● ● ● 16 ● ● ●● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ●● ● ● ● ● ●●● ● ●●● ● ● ●●●● ●● ● ● ●● ● 17● ●● ●● ● ● ● ●●●● ●● ● ●● ● ●● ●●●● ● ● ● ● ● ● ● ● ● ●● ● ● ●18● ● ● ● ● ● ● ● 19 ● ● ● ●● ● ● ● ● ● ●● ● ●●●●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● 18● ● ●● ● ● ● ● ●● ● ●●● ●●●● ● ● ● ●● ● ● ● ●● ● ● ●● ● ● ●●● ● ● ●● ● ● 20 ● ● ● ● ●● ● ● ● ● ● ● 19 ●● ● ● ● ● ●●● ● ● ● ●●● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● 20 ● ● ● ● ● ● ● ●●●●● ● ● ●● ●● ●●● ●● ● ● ● ● ● ●● ● ● ●● ● ●● ● ● ●●● ● ● ● ●●● ● ● ● ●●● ● ● ●● ●●● ● ● ● ● ● ●● ●●● ● ●●● ● ● ● ● ● ● ● ● ● ● ●● ● 21 ● ● ● ● ● ●●●●● ● ●●● ●● ● ●● ● ● ● ●●● ●●●●●● ●●●● ● ●● ●● ● ●●● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ●●● ● ● ● ●● ● ●● ● ●● ● ● ●● ● ● ● ●● ● ● ● 22● ● ● ● ● ● ●● ●● ●●●● ● ● ● ●●● ● ●● ● ● ● ● ● ● ● ● ●● ● ● 23 ● ● ●● ● ● ● ● ● ● ● ● ● 21 ●● ● ● ● ● ● ● ● ● ● ● ● 24 ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ● ● ●22● ● ● ● ●●● ●●● ●● ●●●●● ●● ●● ● ●● ● ● ● ●● ● ● ● 23 ● ● ● ● ● ● ● ● ● ● ● ● ● 24 ● ● ● ● ● ● ● ● ●●●● ● ●● ● ● ●● ● ● ● ● 25 ● ●● ● ● ● ● ●● ● ● ●● ● ●26● ● ● ●● ●● ●● ●● ● ● ● ● ● ● ● ●● ●●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ●●●● ●●25● ●●● ● ● ● ● ●●● ●● ● ●● ● ● ● ● ● ●●●●● ● ● ●● ● ●● ●● ●● ● ● ● ●● ● ● ● ● ● ●● 26● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ●27● ● ● ●● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ●●● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ●●● ● ● ● ●● ● ● ●●● ● ● ● 27● ● ● ● ●● ● ●●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ●●● ● ● ● ●● ● ●● ● ● ● ● ●● 28● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ●● ●● ●●● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ●● ● ●● ● ● ● ● ● ● ● 29 ● ● ● ● ● ● ● ● ● ● ● ● ● ●● 30 ● ● ●● ● ● ● ● ● ● ● ●● 28● ●●●● ● ●●● ● ● ● ● ●● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ●●● ●● ● ●● ●● ● ●● ● ●● ● ● ●● ● ●● ● ●● ●●● ●● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ●●●● ● ● ● ● ● ● 29 ● ● ● ● ● ● ● ● ● ● ● 30● ● ● ● ● ● ● ●● ● ● ● ●31●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ●● ● ● ● ● ● ●● ●●● ● ● ● ● ● ●●●● ● ● ● ● ●● ● ● ● ●● ● ●●● ●● ● ●● ● ●●● ● ● ● ● ●● ● ● ● ●● ●●●●● ●● ● ●●●●● ● ● ●31● ● ● ● ●●●●●●● ●● ●●● ● ● ● ● ● ●● ●● ● ● ● ●● ● ● ● ● ● ●●●●●●● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ●● ●● ● ●●● ● ● ● ● ● ● ●● ● ●●● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ●● ● 32● ● ●●● ● ●●●● ●● ● ● ●●● ● ●● ● ●● ● ● ● ● ●● ●●● ●● ● ● ● ● ● ●● ● ● ●●● ● ● ●33 ● ● ● ● ●●● ● ● ●●● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● 3335 ● 32 3434 37 3635● ● ● 36 ● ● 37 ● ● 38 2 39 40 ● 39 ● 38 ● ● 43 4042 41 ● ● 43 42 41464445 ● 47 48 ● filter: p < 0.01 5153 4949 ● 47 50484644455052 51 ● 5255 54 56 53 57 ● 56 ● 58 57● 55 ● 5954 58 ● ● 6059 ● ● 61 60 ● 62 61● 63● 62 64 65 ● 64 6868696666● 676765 63 70 ● 7169 ● 70 71757272 73737474 ● ● ● ● 75 ● ● 76 76 ● ● ● 77 ● ● ● ● 78 7877● 7979 8080 8282 8181 ● 83848385878684 88 89● 0 9797 858786929395929395 9494 88100100918991 90969096 99999898 0 (cM/Mb) Recombination rate FAM85B CLDN23 LOC157273 TNKS MSRA LOC102723313 BLK CTSB

FAM86B3P MFHAS1 MIR597 LINC00599 LINCR−0001 PINX1 MTMR9 LINC00208 DEFB136

PRAG1 ERI1 MIR124−1 PRSS55 MIR1322 SLC35G5 GATA4 DEFB135

MIR4660 RP1L1 LOC101929229 TDH SNORA99 DEFB134

SNORD3I MIR4286 XKR6 LOC100129129 C8orf49

PPP1R3B C8orf74 MIR598 FAM167A−AS1 NEIL2

LOC101929128 SOX7 LOC101929269 FAM167A FDFT1

8100 8700 10000 11300 11900 Chromosome 8 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.15.chr5

12 1 0.8 0.6 0.4 0.2 0.1 snp / p / or / maf / info / directions a . rs10866641 / 2.79e−11 / 0.94 / 0.43 / 1.000 / 43−14−0 ● ● ●●●● ●● ● a 10 ●● ● ●●● ●●●●● ●● ●● ● ● ● ● ● ● ● ● ●● ●● ●● 40

● ● ● ● ● ● ● ● ● 8 ● ●● p = 5.0e−08 ●● ●● ● ● ●●● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ●●● ●● ● ● ● ●● ● ● ● ●● ● ●● ● ● ●● ● ●●● ● ● ●● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● 6 ● ● ● ● ● ●● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ●● 20 ● ● ● ●● Observed (−logP) ●● ● ● ● ● ● ● 4 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ●●● ● ● ● ● ●●● ● ●● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ●● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● 2 ● ● ● ● ● ●● ● ● ● ● ●●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●●●●●●● ● ● ●● ●●●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ●●● ●● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ●●● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ● ● ●● ● ●● ● ● ● ●● ● ●● ●● ● ● ●● ● ●● ● ●● ● ●●● ● ● ●● ● ●● ●●●●●●●●● ●● ● ● ● ●● ● ●●●●●● ● ●● ●●●●●● ● ● ● ●●● ●●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●●●●● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ●●●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●●●● ●●●●● ● ● ● ● ● ● ●● ● ●●●●● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ●●● ●●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●●●● ● ● ● ● ●● ● ● ● ●●● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ●●●●●● ● ● ● ● ● ●● ● ● ●●●●● ● ● ● ● ●●●●●● ●● ● ● ● ● ● ● ●● 0 0 (cM/Mb) Recombination rate DOCK2

INSYN2B

169200 169300 169400 Chromosome 5 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.55.chr20

12 1 . rs6032067 : Blood_protein_levels(28240269)(3E−14) snp / p / or / maf / info / directions 2 . rs16989763 : Blood_protein_levels(29875488)(2E−35) a . rs67712855 / 4.22e−11 / 0.93 / 0.31 / 0.997 / 46−10−1 3 . rs6124687 : Mean_platelet_volume(27863252)(2E−12)a b . rs6032110 / 1.01e−09 / 0.94 / 0.49 / 0.985 / 44−13−0

10 ● ● ●● ● ● ● ●● 4 . rs11697677 : Blood_protein_levels(29875488)(3E−16)●●● ● ●● ●●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● b ● ● ● b ● ● ● ●● ● 40 ● ● ● ●

● 8 p = 5.0e−08 ● ● ●

● ●

● ● ● ● ● ●

● ● ●● ● ● ●●● ● ● ● ●●● ● ●●●●●●●●● ● ● ● ● ●● ●●●●●●●● ● ●● ●● ● ● ●● ● ● ● ●● ●●● ● ●● ● ●● ●● ● ●● ● 6 ● ●●●●●● ● ●●● ● ● ● ●● ● ● ●● ● ●● ●● ●● ● ●●● ●●● ●●● ● ● ● ●● ● ● ● ● ●● ● ● ●●● ●● ● ●●● ●●●● ●● 1 ● ● ● ●● ● ● ●●●●●●●●●●●●● 1 ● ●● ● ● ● ●● ●● ●● ● ● ● ● ● ● ● ● ● ● 2 ● ●● ● ● ●● ● ● ●● 2 ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● 20 ● ● Observed (−logP) ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● 4 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ●●●● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 3 ● ● ● ● ● ●●● ● ● ● ● ● ● 3 ● ● ● ● ●●●● ● ● ● ● ● ●● ● ● ●● ●●●● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ●● ●● ● ● ● ● ●●●● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ●●●●●●● ● ●● ● ● ● ●●●●● ●●●● ● ● ● ●●●●● ●●● 2 ● ● ● ● ● ● ● 4 ● ● ● ● 4 ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ●●●● ●● ● ● ●● ● ●●●● ● ● ● ●●● ● ●● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ●●●●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ●●●●●●● ● ● ●●● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ●● ●● ● ● ● ● ● ●●● ●●● ●● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ●●● ●● ●●● ●● ● ●●●●●●●● ● ●●●●●●●●●●●●●●●●●●●● ● ● ● ● ●●●●●●●●●●●●●●● ● ●●●●●●●●●●●●● ● ●●●●●●● ● ●●●●●●●● ● ●● ●●● ●●●● ●● ●● ● ●● ●● ●●● ●●●●●● ●●●●●●●●●●●●●●● ●● ● ●●●● ● ● ●●●●● ●●●● ●● ●●● ● ● 0 0 (cM/Mb) Recombination rate PABPC1L WFDC5 SLPI SYS1−DBNDD2

TOMM34 WFDC12 MATN4 TP53TG5

STK4−AS1 PI3 RBPJL

STK4 SEMG1 SDC4

KCNS1 SEMG2 SYS1

43600 43800 44000 Chromosome 20 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.2.chr2

12 1 0.8 0.6 0.4 0.2 0.1 1 . rs56361249 : Bipolar_disorder(28072414)(3E−10) snp / p / or / maf / info / directions 2 . rs2271893 : Blood_protein_levels(29875488)(4E−24) a . rs4619651 / 4.78e−11 / 0.94 / 0.33 / 0.994 / 13−44−0

● Bipolar_disorder(22182935)(2E−10) ●●● a 10 a 3 . rs2579500 : Eosinophil_perc...(27863252)(7E−39)

● ● ● ● ●●● ● Eosinophil_counts(27863252)(8E−39) ●● 1 ●● 1 ● 4 . rs2579519 : Diastolic_blood_pressure(28135244)(5E−12) 2●● ● ●● ● 40 ●●● ●● ● ● ●● ● ●●● ●● 8 5 . rs2692947 : Eosinophil_perc...(27863252)(4E−20) ●● p = 5.0e−08

Neutrophil_perc...(27863252)(2E−18)●

●● ● ● ● ● 6 . rs2708977 : Eosinophil_perc...(27863252)(5E−34)● ● ● ● ● ● ●● ● ● ● ● ● ●●●● Neutrophil_perc...(27863252)(8E−29)● ●●● ●●● ● ● ● ●●● ● ● ● 6 ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●●● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ●● ● ● ● ● 20 ● ● ● ●●● ●● ● ● ●● ● ● Observed (−logP) ●● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ●●● ● ● 4 ● ● ● ● ●●● ● ● ●●●● ● ● ● ● ● ● ● ●● ● ●● ● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ●● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ●● ● ● ●● ●● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ●●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ●● ●● ● ● ● ● ●●● ●●●●● ● ● ● ● ● ● ● ● ● ● ●● ● ●●●● ● ● ● ●●● ● ● ● ●●●● ●●● ● ● ●●● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 3 ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●● ● ● ● ● 3 ● ● ● ● ●● ●● ● ● ● ● ●● ● ●● ● ● ● ● ●● ●●●● ● ● 4 ● ● ● ● ● ● ● ● ● ● ● ● ● ● 4 ● ● ● ●●● ●●● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ●●●●●●●●●●●●●●●●●● ●●●● ● ● ● ● ●● ● ● ● ● ●●●●●● ● ● ● ● ●● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ●● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ●● ●● ● ● ● ● ● ● ●●●● ● ● ● ● ●● ●● ●●●● ● ●●●●●● ●● ● ● ● ● ● ●● ● ● ●● ●● ● ●● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ●●● ● ● 2 ● 5 ● ● ● ● ● ● ● ●● 5 ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ●● ● ● ●● ● ● ●● ●●● ● ● ● ● ● ●●●●● ● ● ●● ● ● ● ● ●●●● ● ● ● ● ●●● ●●● ● ● ● ● ●●● ● ● ● ●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ●●●●● ● ● ● ● ● ● ● ●● ● ● ●●● ● ● ●●● ●● ● ● ● ● ● ● ●● ● ● ● ●●●●● ● ●● ● ●● ●●●●●●●● ●●●●● ● ●●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●●●●●●● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ●● ●● ● ● ● ● ●●●● ●● ●● ● ● ● ● ● ● ●●● ●●● ● ● ● ●● ● ● ● ●● ● ●●●●●● ● ●●●●●●●● ●● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ●● ● ●● ●●●●●●●●● ● ●● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ●● ● ●●● ● ● ● ● ● ● ●●● ● ●●●● ● ●●● ●● ● ● ●● ● ●●● ●● ● ● ● ● ● ● ● ●●● ● ●● ● ● ● ● ● ●● ●● ● ● ● ● ●● ● ●●●● ● ● ●●● ● ● ●● ●●●●● ● ● ●● ● ● ● ●●● ● ● ● ● ● ● ● ●● ● ● ● ●●● ● ● ●●●●●● ● ● ●● ●●●●●●●●●●● ● ● ●●● ● ● ● ● ● ● ● ●●● ● ●●● ● ●● ● ● ● ● ● ● ● ● ● ●●●●● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●●● ● ●●● ● ● ●●● ●● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ●●●● ● ●● ●● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ● ● ●● 6●●● ●● ● ●● ● ●● ● ● ● ●●●●●● ●● ● ● ● ●● 0 filter: p < 0.5 0 (cM/Mb) Recombination rate LINC00342 STARD7 NCAPH CNNM4 FAM178B ANKRD36B

ANKRD36C STARD7−AS1 NEURL3 MIR3127 LOC101927053 FAHD2B COX5B

FAHD2CP SNORA112 LOC105373496 CNNM3−DT ANKRD36 ACTR1B

GPAT2 TMEM127 ARID5A CNNM3 LOC100506076 C2orf92

ADRA2B CIAO1 KANSL3 ANKRD23 LOC100506123 ZAP70

ASTL SNRNP200 FER1L5 ANKRD39 TMEM131

DUSP2 ITPRIPL1 LMAN2L SEMA4C

96400 96700 97400 98100 98400 Chromosome 2 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.47.chr15

12 1 0.8 0.6 0.4 0.2 0.1 1 . rs12908161 : Schizophrenia(26198764)(5E−10) snp / p / or / maf / info / directions 2 . rs66486766 : Bipolar_disorde...(29121268)(1E−11) a . rs748455 / 5.01e−11 / 0.93 / 0.28 / 0.997 / 46−11−0

3 . rs950169 : Schizophrenia(28991256)(5E−12) ● ●● a ●a ● ● ● ● ● 10 ●● ●● ● ●● ● ● ● ● ● Schizophrenia(25056061)(2E−11) ● ●● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ●● ● ●● ●●● ●●●●●● ● ● ●● ● ●●●● ● ● ● ● ● ● ●● ● ● ●● ● ●●● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●●● ● ● ● ● ●● ● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● 1 ● ● Schizophrenia(26198764)(3E−11)● ●●●● ● ● ● 1●● ● ● ●● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ●● ● ● ● ●● ●● ● ● ●● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●● ● ● ● ●● ● ● ● ● 2 ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 2 ● ● ● ● ● ● ●● ●●●● ● ● ●● ● ● ●● ● ● ● ● ● 40 3 ● ●● ●●●● ● 4 . rs35828350 : Autism_spectrum...(28540026)(6E−11)3 ●●●● ● 4 ● ● ● ● ● 4 ● ● ● ●● ●●● ● ● ● ●●● ●● ●● ● ●●●● 8 5 . rs2292462 : Creatine_kinase_levels(29403010)(1E−8)● ● p = 5.0e−08 ● ● ● ● ● ● ● ● ● ●● 6 . rs2115630 : P_wave_terminal_force(28794112)(6E−10) ●● ● ● ●● 7 . rs7176527 : Waist_circumfer...(28448500)(6E−9) ●● ●● Waist_circumfer...(28448500)(1E−8) ●● ● ●●● 6 ●● ● ● ● ●● ● ● ● ● ● Waist_circumfer...(28448500)(2E−8) ● ● ● ● ● ● ● ●●●● ● ●5 ●● ● ●● Waist_circumfer...(28448500)(3E−8)

● ● ● ●● ● ● ●● ● ●● ● ● Waist_circumfer...(28448500)(4E−8)● ● ● ●● ● ● ● ● ● 20 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● Observed (−logP) ● ● ● ● ● ● ● ● ● ●● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ●● ● ●● ●● ● 4 ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● 6 ● ● ● ● ● ● ● 6 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ●● ● ●●● ● ●● ● ● ●● ● ● ● ●● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ●●●● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ●●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ●● ● ●● ●● ● ● ● ● ●● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ●● ● ●● ●● ●● ● ●● ● ●● ●●● ● ● ● ● ●●●● ● ●● ● ● ●● ●● ● ● ● ●●●●● ●●●●●●● ●● ● ● ● ● ●● ● ●●● ● ●● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● 2 ● ● ● ● ● ● ● ●●●● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 7 ● ● ● ● ● ● ● ● ● ● ● ● 7● ● ● ● ●● ●● ● ● ● ● ●● ● ● ●●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●●●●● ● ● ●●● ● ● ● ● ●● ●● ●● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ●● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●●● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ●● ● ● ● ●●● ●● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ●● ●● ● ● ● ● ● ● ●● ● ● ● ●●● ● ● ● ● ● ● ● ●● ●● ● ●● ● ● ● ● ● ● ●●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ●● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ●● ● ●● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●●●●● ● ●● ● ● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ●●●●●● ● ● ● ●● ● ● ● ● ● ●● ●● ●●● ● ● ●● ●● ● ●●● ●●●● ●● ●●● ●●● ●●● ● ● ● ● ●●● ● ● ● ●● ●● ●● ● ● ● ● ●● ●●●● ● ● ●● ●● ●● ● ●●● ●● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ●● ● ●● ● ●● ● ●● ● ●● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ●●● ● ●● ●●● ●● ● ● ● ●● ● ●● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ●●●● ●● ●● ● ● ● ●●● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ●●● ● ● ● ●●● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●●● ● ● ● ●●●●●●●● ●●●●● ● ●● ● ● ● ● ● ●●● ●● ● ●● ●● ● ● ● ●● ● ● ●●● ●●●●● ●●●● ● ● ●● ●●● ●●● ●●● ●● ● ● ● ● ● ● ●● ●●● ●●● ●● ●●● ●●● ● ●●●●●● 0 0 (cM/Mb) Recombination rate ADAMTSL3 LOC642423 GOLGA6L5P WDR73 SLC28A1

EFL1P1 GOLGA6L4 UBE2Q2P1 NMB

UBE2Q2L LOC103171574 LINC00933 SEC11A

LOC440300 LOC102724034 ZSCAN2 ZNF592

GOLGA2P7 DNM1P41 SCAND2P ALPK3

84600 84700 85000 85300 85400 Chromosome 15 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.39.chr11

1 0.8 0.6 0.4 0.2 0.1

snp / p / or / maf / info / directions 10 a . rs12575685 / 1.24e−10 / 1.07 / 0.33 / 0.964 / 45−12−0 ● a ● a ●● ● ● ● ● ●●● ●● ●● ●● ● ●● ● ●● ● ●● ● ● ●● ●● ● ●●● ●●

●● ●● ●● 8 ● ●●● p = 5.0e−08 40 ●●

●● ●● ● ●● ●●

● ● ●● ● 6 ● ● ● ●●● ●● ●● ● ● ●●● ●●

●●

●

● ●● 4 ● 20 Observed (−logP) ● ●● ●● ●● ●

● ● ● ● ● ● ● ●

● ● ●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●● ● ● ● ● ●● ● ● ● ●●●●● ●●●● ●● ● 2 ● ● ● ●● ●●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ●● ●● ●● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●●● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ●● ● ● ●● ● ● ●●● ● ● ●● ●●●● ● ● ● ●● ● ●●● ● ● ● ●● ●● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ●● ●●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ● ●● ● ● ● ●● ● ●● ● ● ● ● ● ● ●● ● ●● ● ● ● ●● ● ●●●●●●● ●●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ●●● ●●●●● ● ●●●●● ● ●● ● ● ● ● ● ●● ● ●● ●● ●● ● ● ●●●● ● ● ● ● ●● ● ● ●● ●● ●●● ● ● ●● ● ● ● ●●● ● ● ●●●●●● ●●● ● ●●●●●● ●●● ●● ● ● ● ● ●●● ● ● ● ● ● ● ● ●●● ●●●●● ● ●●● ●● ●●●● ●●●●● ●● ● ● 0 0 (cM/Mb) Recombination rate SHANK2

SHANK2−AS1

70500 70600 70700 Chromosome 11 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.49.chr16

1 0.8 0.6 0.4 0.2 0.1

1 . rs9039 : Menopause(3E−8) snp / p / or / maf / info / directions 10 a . rs28455634 / 2.63e−10 / 0.94 / 0.38 / 0.937 / 11−46−0 a

●● ●● 8 p = 5.0e−08 40 ●● ●● ●●

●● 6 ●● ●● ●● ● ●● ● ●●●●● ● ●●● ● ●●●● ● ● ● ● ●●●●● ● ● ● ●● ● ●●● ● ● ●● ● ●● ●● ●● ● ●● ● ● ●● ● ● ●● ● ●● ● ● ● ●● ● ●● ● ● ●● ● ● ● ●●● ● ● ● ● ● ●● ● ●● ●● ●● ● 4 ●● ● ●●● ● ●● ● 20 ● ● ● Observed (−logP) 1 ● ● ● ● ● ● ● 1 ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ●● ● ● ●●● ● ●● ● ●●● ● ● ● ● ● ●● ● ●●● ● ● ● ●● ● ● ● ●● ● ●● ● ●● ● ●●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ●●● ●●●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●●● ● ● ●● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ●● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● 2 ● ● ● ● ●● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ●● ● ● ● ● ● ● ●●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ●● ●● ● ● ● ●●● ● ● ● ●● ●● ●●● ● ● ● ● ●●●●● ● ● ● ● ● ●● ● ● ●● ● ● ● ●●● ● ● ●● ●● ● ● ● ● ●● ●● ●●● ● ● ● ●● ● ●● ● ●●●●●●●●● ● ● ● ● ● ●●● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ●● ● ● ●● ● ●● ● ● ● ● ● ● ●●●● ●●● ● ● ● ●● ● ● ●● ●● ● ●● ●● ● ● ● ● ● ● ●● ● ● ●●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●● ● ● ● ●● ● ● ● ● ● ●●●●●● ● ● ●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●●●● ● ●● ● ●●●●● ●● ●●● ● ●● ● ● ●●● ●● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ●●●●●●● ● ● ● ●●● ● ● ●●●●●● ● ● ●●●● ● ● ● ● ●●● ●● ● ● ● ● ●● ● ●● ● ● ● ●● ●●● ● ●● ● ● ●● ● ●●●● ● ● ●●● ● ● ●●●●● ●●● ●● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ●● ● ● 0 0 (cM/Mb) Recombination rate C16orf72

9100 9200 9300 Chromosome 16 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.54.chr17

1 0.8 0.6 0.4 0.2 0.1

1 . rs9901595 : Mean_corpuscula...(29403010)(2E−18) snp / p / or / maf / info / directions 10 2 . rs2269906 : Mean_corpuscula...(28017375)(1E−8) a . rs228768 / 2.83e−10 / 1.07 / 0.29 / 0.976 / 11−46−0 3 . rs227584 : Bone_mineral_density(22504420)(3E−24) a ●● ●● ● ● ● ● ● ● ● ● 4 . rs2857078 : Reticulocyte_count(27863252)(2E−30) ● ●●● ● ● 1●●●●● 2 1●● Red_cell_distri...(27863252)(2E−22) ●● ●● ● ● 8 ● ● ● ● ● 40 ● ● ● ● p = 5.0e−08 5 . rs228769 : Bone_mineral_de...(19801982)(2E−8) ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●●● ●●● ●● ● ● ● ●● ● ● ●● ● 6 . rs1476512 : Immature_fracti...(27863252)(1E−16) 3 ●● ●● 4 ●● 7 . rs9910055 : Total_body_bone...(29304378)(3E−11) ●● 4 5 ● 5 ●● ●● ● ●● ● Total_body_bone...(29304378)(3E−9) ●● ● 6 ● ●● ● ●● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ●● ● ●●● ● ●● ● ● ●● ●● ● ● ●● 8 . rs12602486 : Glycated_hemogl...(24244560)(1E−24) ● ● ● ● ●●● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● 6 ●● ● ● ●● ● 6 ●●●● ● ● ● ●● ●●●● ● 7 ● ● ●● ● ● ● 7 ● 9 . rs144219190 : Total_body_bone...(29304378)(4E−8) ●●●●● ● ●● ● ● ● ●●●● ● ● ●● ● ●●● ● ● ●● ● ● ● 10 . rs9303601 : High_light_scat...(27863252)(4E−11) ● ● ● ●● ●● ●● ● ● ● ● ● ● ● High_light_scat...(27863252)(3E−10) ●● ●● 4 ●●● 20 ● Observed (−logP) ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ●● ● ● ...... ●● ● ● ● ● ● ● ●● ●● ● ● ●● ● ● ● ● ● ● ●● ●● ● ●● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 2 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ●●● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ●● 8 ● ● ● ● ● ●● ● ● ● ● ● ● 8 ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● 9 ● ● ● ● ●●●●●●● ● ● ● ● ● ● 9 ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ●● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ● ● ●● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ●● ●● ● ●●● ●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ●●● ●●● ● ● ● ● ● ● ● ● ● ●●● ● ●●● ● ●● ● ● ● ● ● 10 ● ● ● ● ● ● ●● ● ● ● ●● ● 10● ● ● ● ● ● ● ● ● ● ● 11●● ● ●●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● 11● ● ● ● ● ● ● ● ● ● ● ● ●●●● ●●●● ●●● ● ● ● ● ●● ●● ● ●●● ● ● ●● ● ● ● ● ● ●●●●●●●● ● ●● ●● ●●● ●●● 0 0 (cM/Mb) Recombination rate PYY HDAC5 TMUB2 RUNDC3A−AS1

NAGS LOC105371789 ATXN7L3

TMEM101 C17orf53 UBTF

LSM12 ASB16 MIR6782

G6PC3 ASB16−AS1 SLC4A1

42100 42200 42300 42400 Chromosome 17 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.22.chr7

1 0.8 0.6 0.4 0.2 0.1

1 . rs2390536 : Acute_lymphobla...(29348612)(2E−8) snp / p / or / maf / info / directions 10 2 . rs2285947 : Multiple_cancer...(23103227)(1E−16) a . rs6954854 / 5.94e−10 / 1.06 / 0.42 / 0.996 / 14−43−0 Multiple_cancer...(23103227)(2E−8) a 3 . rs73066442 : Metabolite_leve...(27005778)(1E−10) ●● ● ● ● ●● ● ● 4 . rs56130071 : LDL_cholesterol(25961943)(2E−14) ● ● ●● ● ● ● ●● ● 8 ●● ● p = 5.0e−08 40 5 . rs62439688 : Intelligence(9E−9) ●● ● ●● ●

● ● ● ● ● 6 . rs6979354 : Intelligence(2E−11) ● ● ● ● ● ● ●● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ●● ● ●●● ● ● ● ● ● ● ● ● ● 6 ● ● ●● ● ● ● ●● ●● 1●● ● ●● ● ● ● ●● ●● ●●

●●

● ● ● ● ● ● 4 ● ● 20 ● ● ●● ● ● ● Observed (−logP) ●● ● ●● ●● ●● ●● ●● ●● ● ● ● ●● ●

● ● ●● ● ● ● ● ● ●● ●● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 2 ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ●● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 2● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● 2● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● 3 ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● 3 ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ●● ●● ● ● ● ● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ●● ●●●● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ●● ●● ● ● ●● ●●●●● ●●● ● ●●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ●● ●●●● ●●● ●●●● ● ● ● ●●● ● ● ● ● ●● ● ●● ● ● ●● ●● ● ● ●●●●●● ● ●●● ●● ● ● ● ● ● ● ●● ● ●● ● ● ● ●● ● ●●● ● ●● ●● ●● ● 4 ● ●●●● ● ● ●● ● ● ● ● ● ● ● 4 ●● ●● ● ● ● ● ● ● ● ●●●●●5●● ● ● ● ●● ●● ●●●● ● ● ● ● ● ● ● ●● ● ●●● ● ● ● ● ●● ● ●●● ●●●●●●●●●●● ● ● ●●●● ●● ●●●●● ● 0 5 6 0 (cM/Mb) Recombination rate SP4

MIR1183

DNAH11

21400 21500 21600 Chromosome 7 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.0.chr1

10 1 0.8 0.6 0.4 0.2 0.1 snp / p / or / maf / info / directions a . rs2126180 / 1.62e−09 / 1.06 / 0.46 / 0.993 / 46−11−0 ● ● ● ● ●●●●● ●● ● ● ● ● ● ● ● ● ● ● ●●● a ● ● ● ● ● a ● ● ● ● ● ● ● ● ●● ● ● ●● ●● ●● ● ●● ●● ●● ● ● ● ●● ● ● ● ● ● ●● ● ● ●● ● ● ●● ● ● ●●●● ●● ●● ● ●● ●● ● ●●●●● ● ●●● ● ● 8 ● ● ● ● ●● ● ● ●●●● ● p = 5.0e−08 ●●● ●● ● ● ●● ● ● ● ● ● ●● ●● ●● ● ● ● ● 40 ● ● ●● ●● ● ●● ● ● ●● ●● ● ● ● ● ● ●●● ● ● ●● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ●●●●●● ●● ●● ●● ●●● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ●● ● 6 ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●●● ● ●● ● ● ●● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ●● 4 ●● ● ● ●● ●● ● ● ● ●● ● 20 ● ● ● ● ● Observed (−logP) ●● ● ●● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ●●●●●● ● ●● ● ● ● ● ● ● ●●● ● ●● ● ● ● 2 ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●●●●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ●● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ●●●● ● ● ● ●●● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ●● ●● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ●● ●● ●●● ● ● ● ● ● ● ● ●●●●● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ●● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●●● ● ●●●●● ●● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ●●●● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ●● ● ● ● ● ● ● ● ● ●● ●●● ● ● ● ●● ●●●●●● ● ● ●●● ●● ●● ● ● ●● ●●● ●●●●●●●●●●●●● ● ●●●●●●●●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●● ●●● ●●●● ● ● ● ●● ● ●● ●●●●●●●● ●● ●●●● ●●●●●●●●● ●●● ● ● ●● ●● ●●● ●● ●●●●●●● ● ● ● ●● ● ● ● ● ●●●●●●●●● ●●●● ● ● ●● ● ● ● ●● ● ● ●● ● ●● ● ●●●●● ● ●●● ● ● ●●●●● ●● ●●●● ● ● ● ● ● ●●●● ● ●●● ●●●● ●●●●● ● ●●● ●● ● ●●●●●● ●●● ● ●●●● ● ● ●● ● ● 0 0 (cM/Mb) Recombination rate LINC01748

LOC101926964

60900 61000 61100 61200 Chromosome 1 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.29.chr8

10 1 0.8 0.6 0.4 0.2 0.1 1 . rs7833924 : Platelet_count(27863252)(7E−33) snp / p / or / maf / info / directions 2 . rs6420181 : Mean_corpuscula...(29403010)(2E−9) a . rs6992333 / 1.62e−09 / 1.06 / 0.41 / 0.967 / 11−45−1 ● ●● ●●● ●●● ● ●●●●●● ● ● ● ● ● a ● ● a●● ●●● ● ● ● ● 3 . rs56261297 : Mean_corpuscular_volume(29403010)(1E−8)● ●● ● ●●● ●● ● ● ● ● ● ●●●●● ● ●●●●●● ● ● ● ●●● ● ●●● 1 ●●●● 4 . rs11784833 : LDL_cholesterol(25961943)(2E−10)●● 1 ●● 8 ●● ●● p = 5.0e−08 ● ● ● ● ● 5 . rs7832643 : LDL_cholesterol_levels(28334899)(2E−17) ● ● ●●● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●● ● ● ● ● ●●●●●●●●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ●● ● 2 ● 40 Total_cholesterol_levels(28334899)(3E−14) ● 2 ● ●● 3● ● ● 3● ● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ●●● ● 4 ●● ●● ● ● ● 6 . rs7464572 : Fibrinogen(23969696)(1E−9) ●● ● ● 4 ●●● ● ●●● ● ● ● ● ● ● ●● ● ● ● ● ● 5 ● ● ● ● ●● 6 ● ● 5 ● ●● ● 6 ● ● ●● ● ●● ● ● ● ● Fibrinogen_levels(28107422)(2E−9) ● ● ● ● 7● ● ● ● ● ● 6 ●●● 8 ● ●● ●● ● 7 . rs11783655 : Height(25282103)(1E−9) ● ● ●● ● ●● 9 ●● 8 . rs11780978 : Fibrinogen_levels(26561523)(6E−10) 9 ● ●● ● Osteoarthritis_...(29559693)(2E−9) ● ●●● ●● 4 9 . rs11136341 : LDL_cholesterol(20686565)(4E−13) ●● LDL_cholesterol(24097068)(7E−12) 20

Observed (−logP) ● ● ● ●● Cholesterol,_total(20686565)(9E−10)● ●● ● ● ●● ● ● ● ● ●● ● ● ● ● ● Cholesterol,_total(24097068)(6E−9)●● ●● ●● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 10 . rs6995402● ● : Platelet_count(22139419)(5E−10)● ● ● ● 2 ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ...... ● ● ●● ● ● ● ● ● ● 10 ● 10 ● ● ● ● ● ● ● ● 1111 ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ●●●● ●● ●●●●● ●●●● ● ● ● ● ● ● ● ● ●● ●● ●● ●● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● 12● ● ● ● ● 13 ● ● ● ● ● 12 ● ● ● 13 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● 0 0 (cM/Mb) Recombination rate EPPK1 SPATC1 GPAA1

PLEC OPLAH

MIR661 MIR6846

PARP10 EXOSC4

GRINA MIR6847

145000 145100 Chromosome 8 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.10.chr4

10 1 0.8 0.6 0.4 0.2 0.1 1 . rs17388568 : Self−reported_allergy(23817569)(4E−8) snp / p / or / maf / info / directions 2 . rs59867199 : Chronic_inflamm...(26974007)(7E−20) a . rs112481526 / 1.86e−09 / 1.07 / 0.26 / 0.984 / 15−42−0 3 . rs77087420 : Depressive_symp...(29292387)(4E−9)a

● 4 . rs45510091 : Depressive_symptoms(29292387)(3E−9)● ●● ● 8 ● ● ● ● ● ● ● ● ● ●● p = 5.0e−08 1 ● ●● ● 5 . rs4505848 : Type_1_diabetes(19430480)(5E−13) ●●● ● ●● 2 6 . rs4145717 : Allergic_diseas...(29083406)(9E−27) 40 7 . rs148505069 : Allergy(27182965)(4E−11) ●● ● ●● ●● ●● 8 . rs45515895 : Mean_platelet_volume(27863252)(8E−10)3 ●● ●●●● ●● ●●● ● ● ● ● ● ● ● ● ●● ● 6 ● ●●●● ● 4 ● ● ● ● ● ● 4 ● 9 . rs17454584 : Allergic_sensitization(23817571)(6E−10)● ● ● ●● ●● ● ● ● 5 ● ● ● ● ● ● ● ● ● ● ● ● ● ● 5 ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●● ● ● ● ● ● ● ● ●● ● 10 . rs1127348 : Itch_intensity_...(28199695)(4E−9)● ●● ●●● 6 ●● ●● 6 7 ●● ● ●●● ...... ●● ● ● ● ●●● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● 4 ●● 8 ● ● ● ● ● ● ● 8 ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 9 ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 9 ● ● ● ● ● ● ● ● ● 20 ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● Observed (−logP) ● ● ● ● ●● ● ● ● ● ● ●●●● ● ● ● ●●● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● 10 ● ● ● ● ● ● ● ● ● ● ● ●● 10 ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● 11 ● ● ●● ● ●● 11 ●● ● ● ● 12● ● ● ●● ● ● ● ● 12●●● ● ● ● ● ● ● ● ●● ● ● ● ● ●●● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ●●● ● ●● ● ● ● ●● ●● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ●● ●●● ●● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ●●●●● ● ● ● ●● ● ● ● ● ● ● ●●●●● 2 ● ● ● ● ● ●● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ● ● 13● ● ● ● ● ● 13 ● ● ●●●●● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ●●●●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●●●●●●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●●● ● ● ● ●● ●● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● 14 ●● ● ● ● ● ● ●●●● ● ● ● ● ● ● 14 ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ●●●● ●●●●●● ●●● ●●●● ● ●●●●● ● ● ● ● ● ● ●● ●● ● ●●● ●● ● ● ● ●●● ● ● ● ● ● 15● ●●● ● ● ●● ●● ● ● ● ● ● ●●● ● ● ● ●●●● ● ● ●●● ● ● ●● ● ●●●● ●●● ●●● ●●●●● ●● ●●●● ● ● ●●●●● ●● ●●●●● ●● ●15●● ● ●●●●● ● ● ● ●● ● ● ● ● ● ●●● ●●● ● ● ● ●● ● ● ●● ● ● ●●●● ● ● ●● ●●●●●● ● ●●●● ●●●●● ●●● ●●●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ●● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●● ● ●● ●● ●● ● ● ●●● ● ● ● ●●● ● ● ● ●●●●●● ● ●●● ●●● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●● ●●●●●●● ● ●●● ● ● ● ●● ● ● ● ●● ● ●●● ● ● ● ● ●● ● ●● ● ●●● ● ● 16● ●● ● ●●● ● ●●● ● ●● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● 16● ● ●● ● ● ● ● ● ● 18 ● ● ● ● ● ● 17 ●●● ●●● ● ● ● ●● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● 19● ● ● ● ● 18 ● ● ● ● ● ● ● ● 17 ● 20 ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ●● ● 21 ● ●●● ● ● ● ● ● ● ● ● ● ● 19 ● ● ● ● ● ● ● ● 20● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● 22 ● ● ● ● ● ● ● ●● ● ● 21 ●● ● ● 22 ● 23 0 23 0 (cM/Mb) Recombination rate KIAA1109 IL21

ADAD1 IL21−AS1

IL2

123000 123100 123300 123500 123600 Chromosome 4 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.20.chr7

10 1 0.8 0.6 0.4 0.2 0.1 1 . rs12668848 : Schizophrenia(28991256)(4E−17) snp / p / or / maf / info / directions Schizophrenia(26198764)(1E−13) a . rs12668848 / 1.90e−09 / 0.94 / 0.43 / 0.996 / 10−47−0 ●● ●●a● 2 . rs6461049 : Schizophrenia(23974872)(6E−13) 1●● a ● 2 ●●● ● 3 . rs10275045 : Schizophrenia_o...(24280982)(2E−9)●● ● 8 ●● ●● ● ● ● p = 5.0e−08 ● ●● ● 4 . rs4721295 : Schizophrenia,_...(24166486)(6E−10)● ● ● ● ●● ● ● ● ●●● ● ●●● ● ● ● ● ● ●●● ● ●● ● ● ● ● ● ● ● ● ● ●●● ●● ● ● ●● ●● ●● ● ● ● 40 ● ●● 5 . rs12666575 : Schizophrenia(22688191)(2E−9)●● ●● ●●● ● ● ● ● ● 3 ● ● ● 3 ● ● ● ● ● ● ●● ●●● ● ●● ● ●● ● ● ● ● ● ● ● ● ●● ● ●● 6 . rs4236274 : Bipolar_disorder(27329760)(8E−12) ●4 ● ● ● ● ●4 ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● 5 ● ● ● ● 7 . rs12699477 : Testicular_germ...(28604728)(6E−13)● 5 ● ● ● ● 6 ● ● ● ● 6 ● ● 6 ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ●● ●7 ● ● ● ● ● ● ● ● ● 7● ● ● ● ●● ● ● ● ● ● ● ● ● Testicular_germ...(28604732)(2E−10)●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●● ● ● ● Testicular_germ...(23666239)(6E−9)● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● 8 ● ● ●● ●● ● ● 8 ● ● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ●● ● ●● ● ● ● ● ●● ● ● ● ●● ● ●● ●● ● ● ● ●●● ●● ● ● ●● ● ● ● ● ● ●●● ● ● ● ● ● ● 8 . rs10267593 : Coronary_artery_disease(29212778)(5E−9)● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ●● ● ● ●● ● ● ● 9 ● ● ● ● ● ● ● ● ● ● ● ●●● ● ●● ● ●● ● 9 ● ● ● ● ●● ● ● ●● ●● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● Coronary_artery_disease(29212778)(2E−8)●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● 4 ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● 9 . rs4332037 : Bipolar_disorder(28115744)(2E−9) ●●● ● ● 20 ● 10 ● ● ● 10 ● ● ● ● ● ● ● ● Observed (−logP) ● ● ● ● ● ● ● ● ● ●● ●● ●● ●● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● 10 . rs11766468 :●Hand_grip_strength(29691431)(8E−12)● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●●●● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ●●● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● Hand_grip_strength(29691431)(3E−9) ● ● ●● ● ● ● ● ● ● ● ●● ● ●● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ●●●● ● ● ● ● ●●●●● ● ● ● ● ● ● ●● ● ●● ● ●● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ●● ● ● ● ●● ● ●● ● ● ●●●●●● ● ● ●●●●●●●●● ●● ● ●● ● ● ● ● ● ● ●●● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ...... ● ●●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● 2 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ●● ● ●● ● ● ●● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●● ● ● ● ● ● ● ● ● ●● ● ●●●● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ●● ● ●● ●● ● ● ●● ● ● ●●● ●● ● ● ● ● ●●● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ●●●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ●● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ●● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ●●● ● ● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●● ● ● ● ● ●● ●● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ●● ●● ● ● ●● ● ● ●●● ● ●●● ● ● ●●● ●● ● ●●●●●●●●●●●●●●●●●●● ● ● ● ● ● ● ● ● ● ●● ●●●●●●●●● ● ● ● ● ● ●●●● ● ● ●● ●● ● ●●● ●●● ●● ● ●●●●●●●●●● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ●● ● ●●● ●● ●●●●●● ● ● ● ● ● ● ● ● ●● ● ●● ●● ●● ● ●●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ●●● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ●●● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ●●●● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ●● ●● ● ● ● ● ●● ●●● ● ● ● ● ● ●●● ● ● ●● ● ● ● ● ● ● ●● ●●●●●● ● ●●●● ●● ● ● ● ● ● ●● ● ●● ●●● ●●● ● ● ● ● ● ● ● ●● ● ● ● ● ●●●● ● ● ● ●● ● ● ●● ● ● ● ● ●●● ●● ●●●●●● ●●●●●● ● ● ● ●● ● ●● ● ● ● ● ● ●● ●● ● ● ●●● ● ● ● ●●● ● ●● ●●●●●●●●● ● ● ● ●●● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ●●● ●●●● ● ● ● ● ●● ●●● ●● ●● ● ●● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ●● ●●● ● ● ● ● ● ●● ● ● ●●●●●●●●11●11● ●●● ● ● ●●

0 filter: p < 0.5 0 (cM/Mb) Recombination rate MAD1L1 MIR6836

MIR4655 SNORA114 EIF3B

MRM2

NUDT1

SNX8

1800 1900 2100 2300 2400 Chromosome 7 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.11.chr5

10 1 0.8 0.6 0.4 0.2 0.1 1 . rs17826816 : Bipolar_disorder(24618891)(1E−8) snp / p / or / maf / info / directions 2 . rs78277363 : Cognitive_decli...(26252872)(3E−8) a . rs28565152 / 1.96e−09 / 1.07 / 0.24 / 0.982 / 49−7−1 ●● a ●● ● 8 ●● ● ● 1 p = 5.0e−08 ●● ●● ●● 40 ● ●●

● ● ● ● ● ● ●● ● ●● ●

6 ●● ●● ●●

●●

●● ●●

4 ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ●●● ●● ● ● ● ● ● ● ● ●● ● ● 20 ●● ●●● ●● ● ● ● ●●● ● Observed (−logP) ● ● ● ●●● ● ● ●● ●●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ●● ● ●● ● ● ●● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ●● ●● ● ●● 2 ● ● ● ●● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ●● ● ● ● ●● ●● ●● ●●●● ●● ● ● ● ●● ● ● ●● ● ●● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ●●●●● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● 2 ● ●●●● ● ● ● ● ● 2 ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ●●● ● ● ● ● ● ●● ● ● ● ● ●●● ● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ●● ● ● ●● ●● ● ●● ● ● ●● ● ● ● ●● ●● ●●● ● ● ● ● ● ● ● ● ●●●●●● ●●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ●● ● ● ●● ● ● ● ● ● ●● ● ● ●● ● ●● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ●●●●● ● ●● ●● ● ● ● ●●● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ●●●● ● ●● ● ●● 0 0 (cM/Mb) Recombination rate ADCY2

7500 7600 Chromosome 5 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.38.chr11

10 1 . rs1815739 : Blood_protein_levels(29875488)(8E−12) snp / p / or / maf / info / directions 2 . rs76878669 : Educational_att...(27225129)(4E−8) a . rs475805 / 1.99e−09 / 0.94 / 0.23 / 0.994 / 45−11−1 3 . rs4576826 : Moderate_to_vig...(29899525)(6E−10)a b . rs678397 / 5.46e−09 / 1.06 / 0.46 / 0.998 / 42−15−0 ● ● ●● ● ● ● ● b ● 4 . rs1791679 : Blood_protein_levels(29875488)(3E−18)● ●●●●●b ● ● ● 8 ● ● p = 5.0e−08

5 . rs564343 : Obesity(2E−9)● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ● ●● ●●● ● ● ●●● ● ● ● ●●●●●●● ●● ●●●●●● ● ● ● ●●●● ● ●● ● ● ●● ● ● ● ● ●● ● 40 6 . rs7112925 : Height(25282103)(6E−15)● 1 ● 1 ● ● ● ● ● ● ● ● ● ● ● ● ● Height(20881960)(9E−10)● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 2 ● ● ● ● ● ● ● ● ● 2 ● ●● ●● ● ● ● 7 . rs668210 ●: Cerebrospinal_f...(28031287)(3E−9)●●● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● 6 ● ● ● ● ● ● ●● ● ● ● ● ● 3 ● ● ● ● ● ● ● ● 3 ● ● ● ● ● ● ● ● ● ● ● ●● ● 8 . rs4073582●●●● : Gout(25646370)(6E−9) ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ●● ●●●● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● Gout(27899376)(4E−8) ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● 9 . rs3825068 : Blood_protein_levels(29875488)(3E−15) ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●●● ● ● Blood_protein_levels(29875488)(4E−14) ● ● ● ● ● ●● ● ● ●● ●● ● ● ● ● 4 ● ● ●● ● 4 ● ● ● ●● ● ● ● ●● 4 ● ● ● ●●●● ● ● ● ● ● ● ● ●● ● ●●● ●●●● ● ●●●● ●●● ●● ● ● ● ● ● ● ● 20 ● ● ●

Observed (−logP) ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●●● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● 5 ● ● 5 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ●● ● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ●●● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ●●●● ● ●●●● ● ●● ● ● ● ●● ● ● ● ● ● ●● ● ● ●● ●● ●● ● ● ●●●●● ● ● ● ● ● ● ● ●●● ● 2 ● ● ●● ● ● ● ● ● ● ● ●●● ● ●●● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ●●● ● ●● ● ● ● ●● ● ● ● ● ● ● ●● ● ● 6 ●● ● ●●● ● ● ● ●●● ● ● ● ● ●● ● ● ● ● ● 6 ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ●● ● ●●●●●●●● ● ● ● ●● ● ● ● ● ● ● ● ●●● ●●● ● ● ● ● ● ● ●●●●● ●●● ● ● ● ● ● ● ● ● ● ● ●● ●●● 7 ●● ● ● ● ● ● ● ● ● ● ● ● ● ● 7 ● ● ● ● ● ● ● ●●● ●● ●●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ●● 8 ● ● ● ● ● ●●● ●●●●● ● ● 8● ● ● ● ● ● 9 ● ● ● ● 9●●● ● ● ● ●● ●● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ●●●●●●●● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ●● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ●● ● ● ●● ●●●● ● ● ● ● ●● ●● ● ● ●● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ●● ●●● ●●●● ● ● ● ● ● ●●●● ● ● ● ● ●●●●●● ● ● ●● ● ● ● ●● ●●●●● ● ● ● ●● ●● ●● ● ●● ●●●● ● ●● ● ● ● ● ●● ● ● ● ●●● ● ● ● ● ● ●● ● ● ●● ● ● ●●●● ●●●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ●● ● ● ●● ●●●●●●●●● ●● ● ●●● ● ● ● ●● ● ● ● ● ● ●● ● ● ●●● ●● ●● ●●● ● ● ● ● ● ● ● ●● ●● ● ●●● ● ● ●● ● ● ● ● ●● ● ● ●● ●● ● ●● ● ● ●●● ●●●●● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ●●● ●●● ●● ● ● ●●●●● ●● ●● ● ● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ● ●● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●●● ● ●●● ● ● ●● ● ● ●●● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ●● ● ●● ● ● ● ● ●● ●●● ● ●● ●● ● ●● ●● ● ●● ● ●●● ● ● ● ● ●● ● ● ● ● ● ● ●● ●● ● ●● ● ● ●● ● ● ●● ● ● ● ● ●● ● ● ●●● ●●● ●● ●●●●●●●●●●●●●●●● ● ● ● ● ● ●●●●●● ● ●●● ● ●●●●● ●● ● ● ● ● ● ● ● ●● ● ● ●● ● ●● ● ● ●●●●● ● ● ●● ● ● ● ● ● ●● ● ●● ● ●●●● ●●● ● 0 0 (cM/Mb) Recombination rate SART1 SNORD13F CD248 MRPL11 CTSF SPTBN2 SYT12

EIF1AD PACS1 RIN1 PELI3 CCDC87 C11orf80 MIR6860

BANF1 KLC2 BRMS1 LOC101928069 CCS RCE1 RHOD

CST6 RAB1B B4GAT1 DPP3 RBM14 PC

CATSPER1 CNIH2 LOC102724064 BBS1 RBM14−RBM4 LRFN4

GAL3ST3 YIF1A SLC29A2 ZDHHC24 RBM4 MIR3163

SF3B2 TMEM151A NPAS4 ACTN3 RBM4B C11orf86

65700 65900 66300 66700 66900 Chromosome 11 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.45.chr15

10 1 0.8 0.6 0.4 0.2 0.1 1 . rs56702977 : Fibrinogen_levels(26561523)(2E−9) snp / p / or / maf / info / directions 2 . rs8026198 : Fibrinogen_levels(28107422)(6E−10) a . rs4447398 / 2.61e−09 / 1.09 / 0.13 / 0.984 / 43−14−0 3 . rs1703755 : Fibrinogen_levels(28107422)(2E−9) ●● a 4 . rs62020698 : Triglycerides(25961943)(4E−10) ●● ●● 8 ● ● ● ● ● p = 5.0e−08 ● ● ●● ● ● ● ● ● ● ● ● 5 . rs2412710 : Triglycerides(24097068)(2E−11) ●● ● ●● ●● Triglycerides(20686565)(2E−8) ●● 40 ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●● ● ● ●● ● ● ● ● ● ● ● ● 6 . rs149698681 : Monocyte_percen...(27863252)(8E−13) ● ●● ●● ●● ● ●● ●● ● ●●● ●● ●● ● ●● ● ● ● ●●● ●● ● ● ●●● ● ● ● ● Granulocyte_per...(27863252)(2E−10) ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● 6 ● ● ●● ●●●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ●● ●● ● ● ● ●● Monocyte_count(27863252)(7E−10)● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ●● ● ● ●● ●● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ●●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ●●●●● ● ● ● ● ● ●●●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ●●●●● ●●● ●● ●● ● ● ● ● ● ● ●●●●●●●●● ● ● ● ●● ● ●●●●●●● ●●●● ●●● ● ●●● ●● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ●● ●●● ● ● ● ●● ● ● ● ● ● ●●● ●● ● ● ● ●●● ● ●●●●● ● ● ●●● ●●●●●●● ● ● ● ● ●● ● ● ● ●● ● ● ●●●● ●● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ●●● ●● ● ● ● ● ●●●● ●● ● ● ●● ● ● ● ●●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ●● ●● ● ●● 4 ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ●● ● ● ● 20 ● ● ● ● ● ● ● ● Observed (−logP) ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● 2 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ●●●●●●● ●● ● ● ● ● ● ●● ● ●● ● ● ●● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 1 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● 1 ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ●● ● ●●● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● 2 ● ● ● ●● ●● ● ● ● ●● ● ● ●● ●● ● ●● ● ● ● ● ● ● ● ● ● ●● 2 ● ●● ● ● 3●● ●● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ●● ● ● 3 ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ●●● ●● ● ●●●● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ●●● ● ● ●● ●● ● ● ● ●●● ●●● ●● ● ●● ● ● ● 4 ●●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● 4 ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ●● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ●●●● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●●● ● ● ● ●● ● ●● ● ● ● ●● ● ● ● ● ● ● ●● ●●● ● ● ● ● ● ●●●● ● ● ● ● ● ● ●● ● ● ● ●● ● ●●● ● ● ●●●●● ● ●● ● ● ● ● ● ● ● ● ●● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ●● ● ● ● ● ● ● ●● ● ● ●● ● ●●● ●● ● ● ● ● ● ● ●●● ● ● ● ● ● ●● ●●●●● ●●● ●●●●● ● ● ● ● ● ●● ● 5 ● ●● ● ● ● ●●● ●● ●● ● ● ● ● ● ● ●●● ●●● ● ● ●● ●● ●●●●●● ● ● ● ● ● ● ●●● ●● ●● ●● ● ●●● ●● ●● ●● ● ● ● ● ● ● ●5 ● ● ●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ●●● ●● ●● ● ●●●●● ●●● ● ● ● ● ● ●●●● ●●●● ●● ● ● ●● ● ● ●●● ● ●●●● ● ● ● ● ● ● ●●● ●●●●●●●●●●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ●● ●● ● ● ●●●●●●●●● ● ●●● ● ● ● ● ● ● ● ● ● ● ●●●● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ●●●●●●●●●●●●●● ●● ● ● ●● ● ● ● ●● ●● ● ●● ● 6● ● ● ● ●●● ● ● ● ●● ● ●● ●●● ●● ● ● ● ● ●● ● ● ●●●● ●● ●● ● ● ● ● ● ●● ●●●● 0 6 0 (cM/Mb) Recombination rate PLA2G4F CAPN3 STARD9

VPS39 ZNF106 CDAN1

MIR627 SNAP23 TTBK2

TMEM87A LRRC57 UBR1

GANC HAUS2 TMEM62

42400 42500 42900 43300 43400 Chromosome 15 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.23.chr7

10 1 0.8 0.6 0.4 0.2 0.1 1 . rs2721811 : Depressive_symp...(29292387)(4E−8) snp / p / or / maf / info / directions a . rs12672003 / 2.72e−09 / 1.10 / 0.11 / 0.996 / 16−38−3 a

●● 8 p = 5.0e−08 ●● ● ● ●● ●●● ● ●● ● ● ●● ● ● ●●● ● ● ● ●●● ● ●● ● ● ● ● ●●● ● 40 ● ● ● ● ●● ● ● ● ● ● ●● ● ● ●●● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● 6 ● ● ●● ●● ●● ● ● ●● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ●● ●● ●● ●● ●● ●●●●●● ● ● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ● ● ●●● ●● ●● ●● ● ● ●● ● ●●● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ●● ● ● ● ●● ● 4 ●●● ● ●●

● ●● ●● ● ● 20 ●● ● Observed (−logP) ● ● ●● ● ● ●● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ●●● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● 1 ● ● ● ● ● 1 ● ● 2 ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ●● ● ● ● ●● ● ● ● ●●● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●● ● ● ●● ● ● ● ●● ● ●●●● ● ● ● ● ●● ●●● ● ● ●● ● ● ● ●●● ● ● ●● ● ● ● ●● ● ●● ● ●●●● ●● ● ● ●● ●●● ●●●●●●●●● ● ● ● ● ● ● ●● ● ●●● ●● ●●● ● ● ● ●● ● ● ● ● ● ●●●● ●● ● ● ● ● ● ● ● ●●●●● ●●●●●●●● ● ●● ●●●● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●●● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●● ● ● ●● ● ● ● ● ●● ● ● ●● ●● ● ● ●●●● ● ● ● ●●● ● ●●●● ● ●●●● ● ● ● ● ● ●●● ● ● ● ●●●● ●●●● ●●● ●● ● ● ● ●● ● ● ●●● ●● ● ● ● ● ● ● ● ● ● ● ●●●●●● ●●●●● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ●● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ●●● ●● ●● ● ●● ● ● ●●●● ●●●● ●●● ●● ● ● ●●●●● ●● ●●● ● ● ● ●●● ● ● ●● ●● ●●● ● ●●●●●●●● ● ●●●●●●● ●●●●●●●● ●●●●●●● ●●●● ●●● ● ● ● ●● ●● ● ● ● ●● ● ●● ●● ●● ●● ● ●● ● ● ●● ●●●●●● ● ●● ● ● ●●● ●●● ●●● ● ● ●●●● ●●● ●●●● ●● ● ●● ● ●● ● ●●●●●●●●●●● ●● ●●●●●● ●●●● ●●● ●●●● ● ●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●● ●●●●●●●●●●●●●●●●●●●●●●●● ●●●●●●●●●●●● ●●●●●●●●●●●● ●●●●●●● ●●●●●●●●●●●●●●●●●●●●●●●●●●● ●●●●●●●●●● ● ●● ● ● ● ● ●●● ●●●● ●●● ●●●●● ●●● ●●●●●●●● ●●●●●● 0 0 (cM/Mb) Recombination rate MPP6

GSDME

OSBPL3

24500 24700 24900 Chromosome 7 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.37.chr11

10 1 0.8 0.6 0.4 0.2 0.1 1 . rs10897473 : Immature_fracti...(27863252)(9E−10) snp / p / or / maf / info / directions 2 . rs510372 : Primary_biliary...(26394269)(2E−9) a . rs4672 / 3.42e−09 / 1.11 / 0.08 / 0.98 / 38−18−1 3 . rs1807304 : Serum_uric_acid_levels(29403010)(3E−136) a 4 . rs538147 : Primary_biliary...(21399635)(2E−10) 8 p = 5.0e−08 5 . rs3741404 : Platelet_count(27863252)(4E−9) ●● ●● 6 . rs574087 : Alopecia_areata(25608926)(9E−14) 40

7 . rs694739 : Sarcoidosis(26051272)(3E−16) ●● ●●

●● ● ● ● ● ● 6 Crohn's_disease(21102463)(6E−10)●●●

● Multiple_sclerosis(24076602)(2E−9) ● ●●●● ●● ● ●● Psoriasis_vulgaris(26626624)(2E−9) ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● 8 . rs1212642● : ●●Serum_uric_acid_levels(29403010)(5E−37)

●● ● ● ● ●● ● ● ● ● ● ● ● ●●●● ● ●● ●● ●● ● ●●● ● ● ● 9 . rs663743● ● : Leprosy(25642632)(9E−14) ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● 4 ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● Primary_scleros...(27992413)(2E−13) ● ● ● ● ● ● ● ● ● ● 20 ● ● ● ● ● ● ● ● ● ● ● ● Observed (−logP) ● ● ● ● ● ● ●● ● ●● ● ●●● ●● ● ● ●● ●● ● ● ● ●● ●●● ● ● ● ● ●●●●●● ● ● ● ● 10 . rs588177 : High_light_scat...(27863252)(2E−10)●● ●● ● ● ● ● ● ● ● ● ● 1 ● ● ● ● ●● ● 1 ● ● ● ● ● ●●● ●● ●● ● ● ●● ● ● ● ● ● ● ● ●●High_light_scat...(27863252)(1E−9) ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ●● 2● ●●●● ● ● ●● ● ● ● ● 2●● ● ● ● ● ● ● ...... ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● 2 ●3 5 ● ●● ● ●●●● ● ● ● ● ●●●● ● 4 ● 3 ● ● ● ● 5 4 ● ● ● ● ● ● ● ● ● ●● 76 ● ● ● 8 ● 76 ● 8 ● ● ● ● ● ● ●● ● 9 ●● ● ● ● 10● ● ● 9 ● ● ● 11 ● ● 10 ● ● 11 ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ●●●● ●●●● ●● ● ● ● ●● ● ● ● ● ● ●●● ● ●● ●● ● ● ●●●●● ● ● ● ● ●●● ● ●●●● ●● ● ● ● ● ● ● ● ● ●●●●●●●● ●●●● ● ● ●● ● ● ● ●● ●● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●●●● ● ● ●● ● ●●●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ●● ● ● ● ● ● 12 ● ● ● ●●●●● ● ● ● ● ● ●● ● 12 ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ●● ● ● ●●● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ●●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ●● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●● ●●● ●●● ● ● ●●● ● ● ●● ●● ● ● ● ●● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●● ● ●● ● ●● ● ●● ● ● ● ● ● ● ●●● ● ● ● ● ● ●●●●●● ● ● ● ● ● ● ● ● ● ● ●● ● ●●● ●● ● ●●● ●● ●●●● ●● ● ● ● ● 0 13141314 0 (cM/Mb) Recombination rate OTUB1 TRPT1 PPP1R14B KCNK4 PRDX5 LOC100996455

MACROD1 NUDT22LOC105369340 KCNK4−TEX40 CCDC88B

FLRT1 DNAJC4 PLCB3 CATSPERZ MIR7155

STIP1 VEGFB BAD ESRRA RPS6KA4

FERMT3 FKBP2 GPR137 TRMT112 MIR1237

63800 64000 64200 Chromosome 11 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.24.chr7

10 1 0.8 0.6 0.4 0.2 0.1 1 . rs9655780 : Intelligence(3E−9) snp / p / or / maf / info / directions 2 . rs1142 : Advanced_age−re...(26691988)(1E−9) a . rs11764361 / 3.47e−09 / 0.94 / 0.33 / 0.905 / 45−12−0 3 . rs1144 : Waist_circumfer...(25673412)(3E−8) ●● a 4 . rs41563 : Autism_spectrum...(28540026)(5E−11) 8 p = 5.0e−08 5 . rs6466055 : Schizophrenia(25056061)(1E−9) Schizophrenia(26198764)(1E−9) 40 6 . rs2057884 : Schizophrenia(28991256)(2E−12)

● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● 7 . rs4580973 : Autism_spectrum...(28540026)(3E−10) ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 6 ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ●● ● ●●● ● ● ● ●● 1 ● 1 ● ●● ●● ● ● ●● ● ● ●●●● ●● ●●●● ● ● ● ●● 4 ● ● ●● ● ● ● ● ● ●

● 20 ● ● ● ● ●● ● ● ● ●● Observed (−logP) ● ● ● ● ● ● ●● ● ●●●● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● 2 ● ● ● ● ● ● ● ● ● ● ● 3 ● ● ● ● ● ● ● 2 ● ● ● ● ●● ● ● ● ● 3 ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●● ●●● ● ●● ● ● ● 4 ● ● ● ● ● ● 5 ● ● ●● ● ● ● ● ● 4 ● ● ● ● 5 ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● 6 ● ●● ● ● ● ● ● ● ● 6 ●● ● ● ● ● ● 2 ●● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ●● ● ●● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●●●●●● ● ● ● ● ● ● ● ● ● ●●●●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ●●● ●●●●● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●● ●● ● ● ● ● ●●● ●● ●● ●● ●●● ● ● ● ●● ●●●● ●●●●● ● ● ● ● ●● ●●● ● ● ● ● ●●●●● ●●●● ●●● ●●● ●● ● ● ● ● ● ● ● ● ● ● ● ●●●●●● ●●● ●● ●●●●●● ●●●●● ● ● ●● ● ● ● ●● ● ● ● ●● ● ●●●● ● ● ● ●●●● ● ●●●●●● ●● ●●●●●●●●●●●●●●●●●●●●● ●● ●● ● ● ● ●● ● ●●● ● ● ●●● ●● ●● ● ●● ●● ●● ●● ● ● ● ●● ● ● ● ● ● ● ●●● ● ● ●● ● ●●● ●● ● ● ●●●● ● ● ● ● ● ●● ●● ● ● ● ● ● ●●●●●●● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ●● ●● ● ●● ● ●● ● ●●● ●●●●●● ● ● ●● ●●●●●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ●●● ● ●● ● ●● ●●●● ● ● ●●● ● ● ● ● ● ● ●● ● ● ● ●● ●●● ● ●● ● ● ●● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ●● ● ● ●●●●●●●●●●● 0 7 0 (cM/Mb) Recombination rate LHFPL3 KMT2E

LHFPL3−AS1 SRPK2

LHFPL3−AS2 PUS7

LINC01004

KMT2E−AS1

104400 104600 104800 105000 Chromosome 7 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.48.chr15

10 1 0.8 0.6 0.4 0.2 0.1 1 . rs4702 : Schizophrenia(25056061)(8E−14) snp / p / or / maf / info / directions Schizophrenia(26198764)(3E−12) a . rs4702 / 3.52e−09 / 1.06 / 0.45 / 0.951 / 14−42−1 Autism_spectrum...(28540026)(1E−10) 1 a 8 2 . rs2071382 : Coronary_artery...(28714975)(7E−13) ●● p = 5.0e−08 ● ●● ● ●● 3 . rs17514846 : Coronary_artery_disease(29212778)(8E−27) ● ●● ●● 2 ● Coronary_artery_disease(29212778)(1E−26) 3 2 40 Systolic_blood_pressure(29403010)(3E−8) ●● 6 4 . rs4932373 : Coronary_artery_disease(29212778)(2E−25) 5 . rs8032315 : Autism_spectrum...(28540026)(2E−8) 6 . rs2521501 : Systolic_blood_pressure(21909115)(5E−19) Diastolic_blood_pressure(21909115)(2E−15) 4 Diastolic_blood_pressure(28739976)(1E−13) Systolic_blood_pressure(28739976)(1E−12) ●● 20

Observed (−logP) ●● ● ●● ● ●● ● ● ● ● ● ● Blood_pressure(21909110)(3E−8) ● ● ●●● ● 4 ● 5 ● 4 ● ● ● ● 5 ● ● ●● ● ● ●● ● ● ●● ● ●● ● ● ● ● ● 7 . rs4932370 : Ischemic_stroke(29531354)(3E−8) ● ● ● ● ● ● ● ● ● ●● ● ●● ● ●●● ● ● ● ● 6 ● ● 6 ● ● ● 8 . rs138682554 : Systolic_blood_pressure(28135244)(1E−9)●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● 2 ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● 7 ● ● ● ● ● ● ● 7 ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ●● ● ● ● ●●●● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●●● ● ● ●● ● ●●● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●● ● ●●●●●●●●● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ●● ●●● ● ● ● ● 8 ● ●● ● ● ● ● 8 ● ●● ● ● ● ● 0 0 (cM/Mb) Recombination rate FURIN

FES

MAN2A2

UNC45A

HDDC3

91400 Chromosome 15 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.42.chr13

10 1 0.8 0.6 0.4 0.2 0.1 1 . rs9549367 : Platelet_distri...(27863252)(4E−10) snp / p / or / maf / info / directions 2 . rs9549357 : Blood_protein_levels(29875488)(4E−41) a . rs35306827 / 3.56e−09 / 0.94 / 0.22 / 0.986 / 9−48−0 3 . rs556990 : Blood_protein_levels(28240269)(2E−33) ●● ●● ●a●● ● ● a● ● ● ●● ● ● ● ●●●● ● ● ● ● ●●● ●● ● ● ●● ● ●●● ● ● ●● ●● 4 . rs553316 : Blood_protein_levels(29875488)(4E−58) ● ●● ●● ● ●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ●● ● 8 ● ●●●●●● ●● ● ● ● ●● ● ● ●● ●●●● ●●●●●●●●●●● p = 5.0e−08 ● ● ● ●● ● ● ● ● ● ●● 5 . rs559054 : Blood_protein_levels(29875488)(6E−100) ● ● ●●● ● ●●● 1●●● ● Blood_protein_levels(29875488)(2E−67) 40 ●●● ● ● ● 2 ● ● ● 2 ● ● ● ● ● ● ● 6 . rs3024713 : Blood_protein_levels(29875488)(6E−19)● ● ● ● ● ● ●● ●●● ● ●● ●● ● ●●● ● ● ● ●● ● ●● ●● ● ● ● ● ●● ● ● ● ● ● ●●● ●● Blood_protein_levels(29875488)(1E−13)●●● ● ● ● ● ● ● ● ● 6 ●● ● 4 3 ● ● ● 7 . rs61966459 : Mean_corpuscula...(27863252)(3E−14)●● ●

●● Mean_corpuscular_volume(27863252)(2E−10)● ● ● ● ●●

8 . rs57567837 : Mean_platelet_volume(27863252)(9E−12) ● ●● ● ●● ●●

9 . rs515863 : Blood_protein_levels(28240269)(3E−26)● ● ● ●● ● 4 5 ●● 5 ●● 10 . rs34201467 : Blood_protein_levels(29875488)(8E−57) ● ● 20 Observed (−logP) ●● ● ● ● ● ● ...... ● ●● ●● ●● ●● ● ● ● ● ● ● ● 6 ● 6 ● ● ● ●● ● ● ●

● ● ● ● ● ● ● ●● ●● 2 ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● 7 ● ● ● ●●●●● ● ● ● ● 7 ● ● ●●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● 8●● ●●● ● ●●● ● 9 ● ● ● ● ● ● 10 8 ● 11 ● ● ●● 9 ● ●●● ● ● 10 12 ● ● ● 11 ● ● ● 12 ● ● ● ●● 13 ● ●● 14 ● ● ● ● ● ● ●●● ●● ● ● ● 13 ● 14 ● ●● ● ● ● ● ●● ● ●● ●● ● ● ●●●● ● ● ● ● ● 15● ● ●● ● ● ● ●● ● ● 15● ● ● ● ● ● ●● ●●● ● ● ● ● ● ●● ● ● ● ● 16●● ● 17 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 16● ●● ● 18 ● ● 17 ● ● ● ● 18 ● ● ● ● ●● ● ●● ● ●● ● ● ●● ● ● ● ● ● ● ● 19 ● ●● ● ● ● ● ● ● ●●●●●●●●●●●●● 19● ● ● ● ● ● ● ● ● ●● 20● ● ● 2321●●22 ●● ● ●● ● ● ●● ●●●●●● ●● ● ● ● ● ● ●● ● ● ●● ●● ● ● ●● ●● ●● ● ●●●●●● ●●●●●● ● ● ● 0 252520 2321222828242427272626 0 (cM/Mb) Recombination rate MCF2L PCID2 GRTP1−AS1

F7 CUL4A

F10 MIR8075

F10−AS1 LAMP1

PROZ GRTP1

113800 113900 114000 Chromosome 13 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.19.chr6

10 1 0.8 0.6 0.4 0.2 0.1 snp / p / or / maf / info / directions a . rs10455979 / 4.22e−09 / 0.95 / 0.50 / 0.988 / 13−43−1

●● a ● 8 ●●●●● ● p = 5.0e−08 ●● ●●● ●● ●● ●● ● 40 ●● ●● ●● 6

● ●● ● ●

●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ●● ● ● ● ● ●●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 4 ● ● ● ●● ● ●●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● 20 ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● Observed (−logP) ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ●● ● ● ● ● ● ● ●●● ● ● ● ●●● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● 2 ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●● ●● ●● ● ● ● ● ● ●● ●●●●●●● ●● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ●●● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ●● ● ●● ●●●● ●● ● ● ●● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●● ●● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ●● ● ● ●●● ●●●●●●●●● ●●●●●●● ● ● ● ●●● ● ● ●● ● 0 0 (cM/Mb) Recombination rate RPS6KA2

MIR1913

167000 Chromosome 6 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.56.chr20

10 1 0.8 0.6 0.4 0.2 0.1 snp / p / or / maf / info / directions a . rs237460 / 4.25e−09 / 1.06 / 0.41 / 1.000 / 43−14−0

●● ● ● ● ● ● ● ● ●● ●●a ●● ●● 8 p = 5.0e−08 ●● ●● ●● ●● ●● 40

● ● ●● ●● ●● ●● ●● ●● ●●

6 ● ● ● ●● ●● ●● ●●● ●●● ●●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ●● ●● ● ● ● ●● ●● ●● ●● ●●● ● ● ● ●● ●● ●● ● ● ● ● ●●● ●● ● ● ● 4 ● ● ●● ● ● ●● ●● ● ● ● ● ●●●● ● ● ● ●● ●● 20 ● ●● Observed (−logP) ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ●● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 2 ● ● ●● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ●● ● ● ●● ●●● ● ● ● ● ●●●● ● ● ●● ● ● ●● ●●●●●●●●● ● ● ● ●● ● ● ●● ●●● ●●● ● ● ● ● ● ● ● ●●● ●●●● ●● ●●●● ● ● ● ● ● ● ● ●●● ●●●●●●●●●● ● ● ●● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ●● ● ● ●● ●●●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ●●●●●●● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●● ● ●● ● ● ●● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ●● ● ●● ●● ● ●●● ● ●● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ●●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● 0 0 (cM/Mb) Recombination rate KCNB1

PTGIS

48000 48100 Chromosome 20 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.28.chr8

10 1 0.8 0.6 0.4 0.2 0.1 1 . rs10954968 : Body_mass_index(26426971)(4E−8) snp / p / or / maf / info / directions 2 . rs10503951 : Immune_response...(22542470)(3E−9) a . rs2953928 / 6.25e−09 / 1.12 / 0.07 / 1.000 / 38−16−3 3 . rs10091344 : Body_mass_index(28892062)(8E−9) ●● ●● a ●● 8 p = 5.0e−08

●● ●● ●●● ●● 40 ●● ● ● ● ● ● ● ● ● ● ● ●● ●●● ● ●● ● ● ● ●●● ● ●● ● ●●●●●●● ● ● ●● ●●●● ●● ● ● ● ●● ● ● ●●● ●● ● ● ●●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●●●●● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ●● ●● ● ● ● ● ● ● ●● 6 ●● ●● ●● ● ● ●● ● ● ● ●● ● ● ● ●● ● ● ● ●● ● ● ● ● ●● ● ● ●● ● ●● ●● ●● ●● ● ● ● ● ●● ● ● ●●● ●●●●●●● ● ● ● ●●●●● ● ● ●● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ●●● ●●●● ●● ●●● ●● ● ● ● ● ● ●● ●●●● ● ● ● ●● ● ● ● ●● ● ● ● ● ●●● ● ● ● ● ●● ● ● ● ● ●●● ● ● ● ● 4 ● ●● ● ● ● ● ● ●● ● ● ●● ● ● ●● ● ● ● ●● ●● ●●●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ●●● ● ● ● ●● ● ● ●● ● ●●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● 20 ● ● ● ● ● ● ●●●●● ● ●● ● ● ●●●●● Observed (−logP) ● ● ● ●●● ● ● ● ● ● ● ● ● ● ●●●●● ●● ●● ●●● ● ●●● ● ●● ● ● ● ● ● ●●● ● ● ● ● ●● ●●●● ●●●● ●● ● ● ● ● ● ●● ●● ●● ● ●●● ● ● ● ●●● ●●● ●●●● ● ● ● ● ●● ● ● ● ● ● 1 ● ● ● ●●●● ●● ●● ● ● ●● ● ● ● ● ● 1 ● ● ● ● ●●●●● ● ● ● ● ● ● ● ●●●● ● ● ●● ●●●●● ● ●● ●●●● ●●●●●● ●● ●●● ●● ●●●●● ●●●● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ●●● ● ●● ● ●●●●● ●●● ● ●●● ● ● ● ● ● ●●● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ●● ● ● ●●● ●●● ● ● ●●● ● ●●● ●● ●● ● ● ●● ●● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ●● ●● ● ● ●●● ● ● ● ● ●● ● ● ● ● ● ● ●● ●● ●● ● ● ● ● ● ●● ●● ●● ●● ● ● ● ● ●● ● ● ●●● ● ● ●● ●● ● ● ● ●● ● ● ● ● ●●● ● ● ● ● ●●● ●● ● ● ● ● ● ●● ●●● ●●●●●● ● ● ●● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ●● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ●● 2 ● ●●●● ● ● ● ● ● ● ●●●●●●●●●● ●● ● ●●● ●● ● ● ●● ●●●●●●● ● ● ● ●●●● ● ● ●● ● ● ●●● ● ● ● ●●● ● ●● ●●●●● ● ● ● ●●●●● ●● ●● ● ● ● ● ● ● ●●●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●●●●● ●● ● ● ●● ●●● ● ● ● ● ● ●● ● ● ● ● ●●●●● ● ● ● ●● ●● ● ●● ● ● ● ● ● ●●●● ●● ●●●●●●● ● ●● ● ● ● ● ● ●●●●● ●● ● ● ●● ●●● ● ● ● ●● ● ● ● ● ● ● ● ● ●●● ●●●● ● ● ● ● ● ● ● ● ●●●● ● ● ●● ●● ● ● ● ● ● ● ●●● ● ● ● ●●●●●● ● ● ● ● ●●●●●● ● ●●●●●●●● ● ● ●●●●●●●●●●●●●●●●●●●●●●●●● ● ● ● ● ● ●● ●●● ● ● ●● ● ● ● ● ● ●●●●●●● ●●●●●●●● ●● ● ● ● ● ● ● ● ●● ●●● ●●●●● ●● ●●● ● ● ● ● ● ●●●● ● ● ● ● ● ● ●● ●●● ●● ● ●●●●●●● ● ●●●●●●●●● ●●●● ● ● ● ●●●●● ●●● ● ● ●●●●●●●● ● ● ●●● ●● ●●● ●● ● ● ●●● ● ●● ●●●●●●● ● ●●●● ●●●●●● ● ●●● ● ●●● ●● ●● ● ● ● ●●● ● ● ● ●● ● ● ●● ● ● ● ●● ●● ● ● ● ●● ●● ● ● ● ● ● ● ●●● ● ● ● ● ●● ●●●● ● ●● ● ● ● ● ● ● ●● ●●●● ●● ● ● ● ● ● ● ●●● ● ● ● ●●●●●● ●● ● ● ● ● ●●●● ● ●● ●●● ●●●●●●●●●●●●● ● ● ● ●●●● ●●●● ● ● ● ●● ● ●● ●● ●● ●●●●●● ● ● ● ● ●● ● ●● ● ● ● ●● ● ● ●● ● ●●● ●● ● ● ● ●●● ● ● ● ●●●●● ● ● ●● ● ●●●● ● ● ● ●● ● ●●● ● ● ● ●● ●●●● ●●●●●● filter: p < 0.1 ● 2 3 ●● 0 3 0 (cM/Mb) Recombination rate MAK16 LINC01288 UNC5D

TTI2

RNF122

DUSP26

33400 33700 34300 34900 35200 Chromosome 8 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.51.chr16

10 1 0.8 0.6 0.4 0.2 0.1 1 . rs74836424 : Non−melanoma_skin_cancer(29739929)(5E−18) snp / p / or / maf / info / directions 2 . rs369230 : Low_tan_response(29739929)(1E−522) a . rs12932628 / 6.71e−09 / 1.06 / 0.49 / 0.925 / 42−14−1 3 . rs55637757 : Low_tan_response(29739929)(6E−359) 4 . rs3114908 : Low_tan_response(29739929)(2E−328) a 8 p = 5.0e−08 5 . rs1126464 : Diastolic_blood_pressure(27618447)(6E−15) ●● 40

●● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● 6 ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ●● ●● ● ●● ●● ●● ●● ● ● ●● ● ●● ● ● ●● ●● ● ●● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ●● 4 ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ●● ● ● ● ●● ●●● ● ● ●●●● ● ● ● ● ● ● ● ● ● ●● ●● ● ●● ● ● 20 ● ● ● ● ● ● ● ● ● ● ● Observed (−logP) ● ● ● ●● ● ● ● ●● ●●● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●●● ● ●● ● ● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 1 ● ● ● ● ● ● ●● ● 2 ● ●● ● ● 1 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● 2 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ●●● ● ● ● ● ● ● 3 ● ●● ●● ●●●● ● ● ● ●● ● ● ● 3 ●● ● ●●● ● ●●●● ● ● ● ● ● ● ● ● ●●●●● ●● ● ● ● ● ●● ● ● ● ● ●●●●●● ● ●● ● 2 ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● 4● ●●● ●●● ● ● ● ● 4 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ●●●●● ● ●● ● ● ● ●● ●● ●● ● ●● ● ● ● ● ● ● ●●● ●● ● ● ● ●● ● ● ● ● ●● ●●●●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●●●●● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ●● ● ● ● ●●● ● ● ●● ● ● ● ● ● ● ● ●● ● ●● ● ● ●●● ● ●●● ● ● ●● ●●● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ●●●●● ●● ●● ● ●● ● ● ● ● ● ●● ● ●● ●●● ● ●● ●● ●● ● ● 0 5 0 (cM/Mb) Recombination rate ANKRD11 RPL13

LOC105371414 SNORD68

LOC100287036 CPNE7

LOC101927817 DPEP1

SPG7

89400 89500 89600 89700 Chromosome 16 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.1.chr1

10 1 0.8 0.6 0.4 0.2 0.1 snp / p / or / maf / info / directions a . rs10737496 / 7.17e−09 / 1.06 / 0.44 / 0.992 / 14−43−0

● ●● ● ●●● ● ● a● ● ● a● ● ● ● ●●● ● ●● 8 ● ● ●●●● ●●● p = 5.0e−08 ●● ●● 40 ●●

● ● ● ● ●● ●● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●● ● ●●● ● ● ● ●● ●● ● ● ●● 6 ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ●● ●●● ●● ● ● ●● ● ● ●● ● ● ● ● ●●●

● ● ●● ●● ● ● ●●● ● ● ● ● ●●●●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●●●●● ● ●●● ● ●●● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● 4 ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ●● ● ● ●● ●● ● ● ● ● ●● ●● ● ● ●● ● ●● ●● ●●● ●● ● ● ●● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ●●● ●●● ● ● ● ● ● ●● ● ● ● ● ● 20 ● ●●● ● ●● ● ●●● ●●●● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ●● ●● ● ●● Observed (−logP) ●●● ●●● ● ● ● ● ● ●● ●

● ● ●●● ● ● ● ● ● ● ● ● ● ●●● ● ●● ● ●●● ● ● ●●●●● ●● ● ● ● ● ● ●● ● ● ●● ● ●● ●● ● ●● ● ● ●● ●● ● ● ● ● ● ● ●●● ●● ●●●● ●●● ● ● ● ●●● ● ●● ●● ●● ● ● ●● ●● ● ● ● ● ● 2 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ●●● ● ● ● ●●●●●● ●●● ●● ●●● ● ●● ● ● ● ●●●●● ●● ● ●●● ● ● ● ● ● ● ● ● ● ●●● ● ● ●● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ●●●●●●●●●● ● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●● ● ● ● ●● ● ● ● ● ● ● ●●● ● ●● ● ● ● ● ● ● ●● ● ●● ● ●●● ● ● ●● ●●● ● ● ●●● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ●● ● ●● ● ● ● ● ●●● ●●● ● ●●● ● ● ●● ● ● ● ● ● ●●● ● ●● ● ● ●●●● ●●●● ●● ● ● ●● ●● ● ● ● ●● ●●● ● ● ● ● ● ● ● ●● ●●● ● ● ●●● ● ● ●●●● ●●●●●●●●●●●●●●●●●●●●●●●●●●●● ●●● ●●●●●●●●●●● ●● ● ●● ●● ● ● ●●● ●● ●● ●●● ● ● ●● ● ● ●● ●●●●●●●● 0 0 (cM/Mb) Recombination rate

163600 163700 163800 Chromosome 1 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.57.chr20

10 1 0.8 0.6 0.4 0.2 0.1 1 . rs6143006 : Lumbar_spine_bo...(29499414)(2E−8) snp / p / or / maf / info / directions 2 . rs4925386 : Colorectal_cancer(20972440)(2E−10) a . rs13044225 / 8.50e−09 / 1.06 / 0.44 / 0.985 / 13−43−1 3 . rs62199218 : Blood_protein_levels(29875488)(1E−31) a 8 ●a ● ●● ● ● ● p = 5.0e−08 ●● ● ●●● ●● ● ● ● ● ● ● ●●● ●● ● ● ● ● ● ●● ● ● ● ●● ● ● ● 40 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ●●●● ●●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ●● ● ● ● ● ● ● ● ● 1● ● 1● ● 6 ●● ● ●● ● ● ● ●● ● ●● ●● ●● ●● ●● ●●

●● ● ●●

4 ●● ●● ●

● ●● ● 20 ● ● ● ● Observed (−logP) ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● 2 ● ● ● ● ● ● ● ● ● ●● ● ●●● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ●● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●●● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ●●●● ●●●●●●●●● ● ● ● ● ● ●● ● ● ● ● ● ● ●●● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ●●●●● ● ●●● ● ● ●●● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ●● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ●● ● ●● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 2 ● ● ● ● ● ● ●● ● 2 ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●●● ●●● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ●● ●● ● ●●●●●●● ● ● ●● ● ● ●● ● ● ● ● ●● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ●●● ● ● ●●● ●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ●● ●●● ● ●●● ● ●● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ●●● ●● ● ●● ●●3● 0 3 0 (cM/Mb) Recombination rate SS18L1 LAMA5

MTG2 MIR4758

HRH3 LAMA5−AS1

OSBPL2

ADRM1

60800 60900 Chromosome 20 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.13.chr5

10 1 0.8 0.6 0.4 0.2 0.1 snp / p / or / maf / info / directions a . rs6887473 / 8.81e−09 / 0.94 / 0.26 / 0.992 / 17−40−0

● ●● ● 8 a●● ● p = 5.0e−08 ●● ●● ● ● ●● ● ●● ● ● ● ● ● ●● ●● ● ●● ● ● ●● ●●● ● ● ●● ● 40 ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ●● ●● ● ● ● ●● ● ● ● ● ● ●● ● ●●● ● ● ●● ●● ● ●● ● ● ● ● ● ● ● ● ●●● ● ●● ● ●● ● ● ●●● ● ●● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● 6 ●● ●● ●●

●● ●● ●●

●● ●● ●● ● ● ●● ● ●●● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ●● ● ●● ●● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●●● ● ●● ● 4 ●● ●● ● ● ● ● ● ●● ● ●● ●● ●● ●● ●● ● ● 20 ●● ● ● ● ● ● ●● ● ● Observed (−logP) ● ● ● ● ● ● ●● ● ● ●● ●● ●● ● ● ● ● ●● ● ● ●● ● ● ●● ●● ● ● ●●●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ● ●● ● ●●● ● ● ● ● ● ● ●● ● ● ● ● ● 2 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ●● ● ● ●● ●●●●●● ● ● ● ● ● ● ●● ●●●● ●●●● ● ● ● ● ●● ● ●● ● ● ● ● ● ●● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ●● ● ● ●● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ●● ● ● ●● ●●● ●● ●● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●●●● ● ●●● ● ●●● ● ● ●●●● ● ● ●● ● ● ● ●●● ● ● ●● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●●●●●●● ●●● ●●●●● ●●●●●●●● ● ●●●● ●● ● ● ● 0 0 (cM/Mb) Recombination rate RNU5E−1

RNU5D−1

ACOT12

SSBP2

80700 80800 80900 81000 Chromosome 5 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.46.chr15

1 0.8 0.6 0.4 0.2 0.1

1 . rs12439619 : Intelligence(1E−8) snp / p / or / maf / info / directions 2 . rs783540 : Schizophrenia(28991256)(3E−8) a . rs62011709 / 1.43e−08 / 0.94 / 0.25 / 0.998 / 16−41−0 3 . rs2134046 : Cognitive_ability(29186694)(2E−8) 8 ●● ●● ●●a●● p = 5.0e−08 4 . rs1972460 : Intelligence(2E−10) ●● ●● ● ●●● ●● ●●

● ● 40 ● ● ● ●● ● ● ●● ● ● ● ● ● ●● ● ●●●● ● ●● ● ● ● ● ●● ●●●● ● ●● ●● ●●● ● ● ●● ●●● ● ● ● ● ●● ● ● 6 ●● ● ● ●● ●●● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ●●●●●● ● ● ●●● ● ●● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ●●● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ●● ● ● ●● ●● ● ● ●●●●● ● ● ● ● ● ● ● ● ● ●● ●● ●● ● ● ● ●● ● ● ●●●●●●● ●● ●● ● ●●● ● ● ● ● ●● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ●● ●● ● ● ● ● ●● ●●● ● ● ● ●●●● ●●●● ● ●●●● ● ● ● ●● ●●● ● ● ●● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ●●● ● ● ● ● ● ● ● ●● ●● 1 ● ● ●● 1 ● ● ● ●●● ● ● ● ●● ● ●● ● ● ● ● ●● ● ●● ● ●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● 4 ● ● ● ● ●● ● ● ● ● ● ● ● ●● ●●● ●● ● ● ● ●● ● ● ●● ●●● ● ● ● 2 ● ● ● ● 2● ●●●● ●●● ● ●● ● ● ● ● ● ● ●●●● ● ● ●● ● ● ●● ● ● ● ● ●● ●● ● ● ●● ● ● 20 ● ● ● ● ● ● ● Observed (−logP) ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ●●● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● 3 ●● ●● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● 3 ●● ● ●● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ●● ●●● ●●●●●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● 4● ● ●● ● ● ● ● ● ●●●● ● ● ● 4● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ●● ●● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●● ●● ● ●● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● 2 ● ● ● ● ● ● ● ●● ● ● ● ●●● ● ●●● ● ● ● ● ● ●● ●● ● ● ● ● ●●● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ●● ● ● ●● ● ●● ●●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ●● ● ● ● ● ● ●● ●● ●● ● ● ●● ● ● ● ●● ● ● ● ●●●●●●● ● ● ● ● ● ● ● ● ●●●●● ● ● ●● ● ● ● ●● ●● ● ● ●●● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ●●●● ● ● ● ● ● ● ● ●●● ●● ● ● ● ● ●● ●● ● ● ● ● ●●●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ●● ●● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ●●●● ●● ●●●●●●● ●● ● ● ● ● ● ● ● ● ● ● ●● ●●● ●● ● ● ● ● ●● ●●●●●● ●●●● ●●●●●●●●●● ● ●● ● ● ●●● ● ● ●●●●●●● ●● ● ● ●● ● ● ● ● ●●●●●● ●● ● ●●●●●●●●● ● ●●●●●●●● ●●●● ●● ● ● ● ● ● ● ● ● ●●● ● ● ● ●● ●●●●●●●●●● ● ● ●●●● ●●●●● ● ● ● ● ● ●● ● ●●● ●●●●● ● ● ● ● ● ●● ●●●●● ●●●●● ●● ● ● ● ●● ●● ●● ● ● ● ●●● ●● ● ●● ● ●●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ●●● ●●● ● ● ● ●● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ●● ●●●● ●●● ● ● ●● ● ● ●●● ●●● ● ● ● ● ●● ● ● ● ● ● ● ●●● ● ●● ●●●●●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ●●●● ● ●● ● ● ● ● ● ●● ●●● ● ● ● ● ● ● ●●●● ● ● ● ●● ●●● ● ● ● ● ●● ● ● ● ● ●● ●● ●●●●● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ●●●●● ●●●● ●●●●●●●●●●●●● ●● ● ● ●● ● ●●● ●● ●●●●●●●●●●●●●●●●●● ●●● ● ●● ● ●● ● ● ● ● ●● ● ●● ● ●● ● ● ● ● ● ● ● ●●●● ●● ●●●●●●● ● ● ● ●●●●●● ● ●●●● ●●● ●●●●● ●● ● ●●● ●●●●●● ●● ●●● ● ●●● ●● ● ● ● ●● ●● ● ● ●● ● ●● ● ● ● ● ●●●●●●●● ●●●● ●●● ●● ●● ●●●●●● ● ● ● ●● ● ● ● ●● ● ● ●● ●● ● ●● ●●● ● ●●● ●● ● ● ● ●●●●●● ●●●● ●●●●●●●● ●●●●●●●●● ●● ● ● ●● ●●●● ● ● ●●● ● ● ●●● ●●●●●●●●●●●●●●●●●●●●●●●●●●●●● ● ● ●● ●● ● ●● ● ●●●●●●●●●●● ●●●●●●●●●●●●●● ●●●●● ● ● ● ●●●●●● ● ●●●●●●●●●●●●●●●● ●● ● ● ●● ● ● ● ●● ●● 0 0 (cM/Mb) Recombination rate EFL1 RPS17 LOC727751 ACTG1P17 HOMER2 TM6SF1

SAXO2 ADAMTS7P1 CPEB1 SNHG21 RAMAC HDGFL3

GOLGA6L10 LOC102724034 CPEB1−AS1 FSD2 C15orf40 BNC1

GOLGA6L17PUBE2Q2P2 AP3B2 SCARNA15 BTBD1

GOLGA6L9 GOLGA2P10 LOC338963 WHAMM MIR4515

82500 82800 83300 83800 84100 Chromosome 15 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.26.chr7

1 0.8 0.6 0.4 0.2 0.1

1 . rs9648716 : Type_2_diabetes(28869590)(1E−9) snp / p / or / maf / info / directions a . rs10255167 / 1.60e−08 / 0.94 / 0.22 / 0.993 / 44−12−1 8 ●●a p = 5.0e−08

● ●● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●●● ● ●● ●● ● ● ●●●●●● ● ● ● ● ● ● ● ● ●● ● ● ●● ●● ● 40 ●● ● ●● ●● ●● ● ●● ●● ●●● ●●●● ● ● ●●● 6 ● ● ●● ● ● ● ● ● ●● ●● ●● ●●

●● ●● ●● ● ● ●● ●● ● ● ●●● ●●● ●● ● ●●●●●●●● ●●● ● ● ● ● ● ● ●●●● ●● ● ● ●● ● ● ● ● ● ● ● ●●●●● ●●●●●●●●● ●● ● ●● ●● ●● ●● ●● 4 ● ● ● ● ●● ● ● ● ● ● ● ●●● ● ●●● ● ● ● ●●● ● ● ●● ● ●● ●● ●● ● ●● ● ● ●● ● ● ● ●● ● ●● ● ● ● 20 ● ● ● ●● ● ● ● ● ● Observed (−logP) ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●●● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ●●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ●●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ●●● ● ● ● ● ● ● ●● ● ● ● ●●●● ●●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ●●● ●● ● ● ●● ● ● ●● ● ● ● ● ● ●●● ●●●●●● ● ●● ● ● ● ● ● ● ●● 2 ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ●●● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●●●● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ● ● ● ● ● ● ● ● ● ●●●●●●●●●●●●● ●● ● ● ●● ● ● ●● ● ● ● ●● ● ● ● ●●● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ●● ● ● ●●●● ●● ● ●● ● ● ● ● ●●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ●● ● ● ● 1 ● ● ● ● ● 1● ● ● ●●● ●●● ●● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ●●●● ●●● ●●●●●●●● ●● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ● ●●●● ●●● ● ● ● ● ● ● ● ● ● ●● ● ●●● ● ●●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ●● ● ●●● ● ● ● ● ● ● ● ● ● ●● ●● ●● ● ●●●● ● ●●●●●●●●●●● ● ● ●● ● ● ●●●●●●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ● ●● ● ● ● ● ● ●●●● ● ●● ● ●●●● ● ● ●● ● ● ● ● ● ● ● ●● ●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●●●●● ● ●●● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ●●● ●● ●● ●● ●● ● ● ● ●●●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●●●● ●●● ●●●●● ● ●●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●●● ●●● ●● ●● ●●●●● ● ● ● ● ●●● ● ●●●● ● ●●● ●●●●●● ●● ●●●●●●● ●●● ● ●●●● ●● ●● ●● ● ● ●●●● ● ●●●●●●● ●● ● ●● ● 0 0 (cM/Mb) Recombination rate DENND2A MRPS33

ADCK2 TMEM178B

NDUFB2−AS1

NDUFB2

BRAF

140200 140300 140500 140700 140800 Chromosome 7 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.53.chr17

1 . rs8072548 : Eosinophil_perc...(27863252)(1E−29) snp / p / or / maf / info / directions Neutrophil_perc...(27863252)(7E−27) a . rs61554907 / 1.64e−08 / 1.09 / 0.12 / 0.944 / 43−13−1 2 . rs25645 : Myeloid_white_cell_count(27863252)(6E−191) b . rs11870683 / 2.79e−08 / 0.94 / 0.35 / 0.975 / 18−38−1 8 ● a p = 5.0e−08 3 . rs35272691 : White_blood_cel...(28158719)(5E−11) b a 4 . rs4794820 : Asthma(22561531)(1E−8) ● 5 . rs9303277 : Primary_biliary...(26394269)(3E−11) 40 ●● ● Primary_biliary...(28062665)(8E−11) 6 Primary_biliary...(20639880)(2E−9) ● ●● ● ●● ● ● ● ● ●● ● 1 ● ● ● Primary_biliary...(23000144)(4E−9) ●1 ● ●●● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● 4 32 ● Lymphocyte_counts(29403010)(2E−8) 4● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● 5 ● ●● ● ● ● ● 5 ● 6 . rs8067378 : Primary_biliary_cirrhosis(22961000)(6E−14)● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ●●● ●● ● ● ● ●●●●●● ● ●●● ●● ●● ● ● ●●●●● ●●● ●● ●● ● ●● ● ● ●●●● ● ●● ●● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● 6 ●● ●● ● ● ●● 7 ● ● ● 86 ●● ● ● ● ● ● 7 ● 9 ● ● ●10 ● ● ● ● 8 ● ● ● 9 ● 4 ● 10 ● ● ● 11 ● ● ● ● Cervical_cancer(23817570)(9E−10) 12 ●● ● 14 ● 13 ● ● ● 11 15 ● ● ● ● ● 16 ● 12 ● 13 ● ● 14 ● ● ● 1516 ● ● ● 17● ● ● ● ●● ● ● ● 18 19 ●● ● ● 171820 ● ● ● ● 19 ●● ● 20 ● 2221 ●●●● ● ● ● 2221 ● ● ● 23 ● ● 24 ● ● 23 25 24 25 ● 7 . rs2952156● : Asthma(29273806)(2E−30)● ●●● ● ● 20 ● ● ● ● ●● ●● Observed (−logP) ●●●●● ● ●●● ● ●●●● ● ● ● ● ●● ● ● ●● ● ● ● ● ●● 26 ● 27● ● 26 8 . rs1293640927 ● : Rheumatoid_arth...(24532676)(1E−10) ● ● ● ● ● ● 28 ● ● 28● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● 9 . rs2872507● : Ulcerative_colitis(21297633)(5E−11) ● ● ● ●●●● 29● ● 29● ● 30 ● ● 3031 ● ● ● 31 ● ● ● ● ●●●● ● ● ● 32 ● ● ● 32 ● ● Crohn's_disease(21102463)(2E−9)● ● ● ● 2 ● ●● ● ● ● ●●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 33● ● ● ● ● 33● ●●●●●●● ● Rheumatoid_arth...(23143596)(3E−9)● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ●●● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● 34 ●● ● ● ● ● ● ● ● ● ●● 35●●●● ●●●●●● ● ● ●●● ● ● ● ● ●●● ●● ● 34 3637 ● ● ● 403938● ● ● ● 3536 ● ● 37 ● 41 ● ● ● ● ● 38 ● ● ● 39 40 ● ● ● ● ● 4243 ● ● ●●●● ● ● ●●●● 41 ● ● ● ● ● ● 42 ● ●● ● ● ●● ● ● ● ●● 43 ● ● ● ●● ● ● ● ●Crohn's_disease(18587394)(5E−9)● ● ● ● ●●● ●● ●●●●●● ● ●● ●●●● ●● ●● ● ● ● ● ● ● ● 44● ● ●● ●● ● ● ● ● ● ●●●●● ●●●●●●●● ● ● ● ● 44 ● ● ● ● ●●●●● ● ●● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●●●● ●●●●●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●●● ● 45● ●●● ● ●● ● ●● ● ● ●●● ● ● ●●● ● ●●●● ●●●●● ● 46 ● ● ● ● ● ●●● ● ● ● ● ●●● ●● ● 45● ● ● ● ● 46 ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 10● ●.● ●rs35736272● : Chronic_inflamm...(26974007)(6E−30)● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ●●● ● ●● ●● ● ●● ● ● ● ● ● ●● ● ● ● ●● ●●● ●● ● ● ● ● ● ● ● ●●● ● ●● ● ●● ● ●● ●● ● ● ● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ●● ● ● ●● ● ●● ● ● ●●●●● ● ● ● ●●● ● ● ● ●●● ● ● ● ● ● ●● ● ● ●●●●●● ● ●● ●●●● ● ● ● ●● ●● ●● ● ● ●● ● ●● ● ● ● ●●● ● ● ● ● ●● ●● ●●●● ●● ● ● ● ● ●● ● ●●● ● ●●●●●● ● ● ● ●●● ● ● ● ● ● ● ● ●● ● ● ●● ●●● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ●●● ●●●●●●●●●● ● ● ● ●●● ●● ●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●● ●●●● ●●●● ● ●47● ●●●● ● ● ●●●●●● ● ● ●●● ● ● ● ● ● ●●● ●● ●● ● ● ●● ● ● ● ●● ● ● ● ●● ● ● ● ●● ●● ●● ● 48 ● ● ● ● ● ● ● ● ●●● ●● ● ●●● ● ●●● ●● ● ● ● ● 48● ● 47 ● 0 ...... 4949 5050 5252 5151 0 (cM/Mb) Recombination rate PPP1R1B MIR4728 ORMDL3 MIR6884 MIR6866 RARA−AS1

STARD3 MIEN1 LRRC3C SNORD124 RAPGEFL1 GJD3

TCAP GRB7 GSDMA THRA MIR6867

PNMT IKZF3 PSMD3 NR1D1 WIPF2

PGAP3 ZPBP2 CSF3 MSL1 CDC6

ERBB2 GSDMB MED24 CASC3 RARA

37800 37900 38200 38500 Chromosome 17 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.12.chr5

1 0.8 0.6 0.4 0.2 0.1

snp / p / or / maf / info / directions a . rs6865469 / 1.65e−08 / 1.06 / 0.27 / 0.996 / 40−17−0 8 ●● a p = 5.0e−08 ●● ●● 40 6 ●●

●●

● ●●●

●● ●● ● ●● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ●●● ● ● ● 4 ● ● ● ● ● ● ●● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ●●● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ●● 20 ●● ● ●● ● ● ● ●● Observed (−logP) ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ●● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●●●● ● ● ● ● ● ●● ●● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ●● 2 ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ●●● ● ● ● ● ●● ● ●●●● ●●● ● ● ● ● ● ●● ●● ● ● ● ● ●● ● ● ● ● ●●● ● ●● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ●● ● ● ● ●● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ●●● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ●●●●●●● ● ● ● ● ● ● ● ● ● ●● ●● ● ●● ● ● ●● ● ●●●●●●● ● ● ● ● ●●●●●●●●● ●● ●●●●●●●●●●●●●●●●●●● ●●●●●● ●● ●● ● ●●●●●●●●●●●●●●●●●●●●●●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●●● ● ●●● ● ● ●● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ●●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ●●●● ●●● ●● ●●●● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●●●●●● ● ● ●● ●● ● ● ●● ● ● ● ●●● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ●● ●● ● ●● ●●●●●●●●●●●●●●● 0 0 (cM/Mb) Recombination rate HOMER1

TENT2

CMYA5

78800 78900 79000 Chromosome 5 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.50.chr16

1 0.8 0.6 0.4 0.2 0.1

1 . rs7191183 : Autism_spectrum...(28540026)(2E−9) snp / p / or / maf / info / directions 2 . rs9922678 : Schizophrenia(26198764)(2E−9) a . rs7199910 / 1.66e−08 / 1.06 / 0.31 / 0.99 / 13−44−0 8 Schizophrenia(28991256)(3E−9) ● ● ● p = 5.0e−08 Schizophrenia(25056061)(1E−8) ●a●● ● ● ● ●● ● ● ● ● ● ●●●● ● ● ●●● ● ●● ● ● ● ●● ● ● ● ●●● ●●● ● ● ● 3 . rs11866328 : Hepatitis_B(22004137)(2E−8) ●● ● ● ● ●●●● ● ● ●● ● ● ● ●● ●● ● ● ● ●● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ●●● ●●● ● ● ● ● ● 40 ● ● ●● ● ●● ● ● ● ● ● ● ●●● ● ● ●●● ●● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ●● ● ●●●●● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●●●1 ● ● ● ●●●●● 1 ● ●● ● ● ● ● ● ●●● ● ●● ● ●●●● 6 ● ●●● ● ● ● 2 ● ● ● 2 ● ●● ● ●● ●●●● ● ●● ●● ●●

● ● ●● ●● ●●● ●● ●● ● ●● ●● ●● ●● ● ● 3 ● ● 3 ● ●● ●●● ● ●● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ●● ●● ● ● ● ●●● ● ● ● ● ●●● ● ● ● ● ● ● ● ●●● ● ● ● ●● ● ● ● ● ● ● ●● ●● ●● 4 ● ● ● ●● ● ● ●● ● ● ●● ● ●●●● ● ●● ● ● ●●● ● ●● ●● ● ● ● ●●● ● ● ●● ● ●●●●●● ● ●● ● ●● ●●● ● ●● ●● ● ● ● ● ● ● ● ●● ●● ● 20 ●

Observed (−logP) ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ●● ●● ● ●● ● ● ● ● ● ● ●●●● ●● ● ● ●● ● ● ● ● ●● ●● ●●● ● ●●● ● ●●● ● ● ●●● ●●●●●●●● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ●● ● ● ● ● ●● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ●● ● ●●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● 2 ●●● ●● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●●●●●●● ● ●● ● ● ● ● ● ● ●●● ●● ●● ● ● ●●● ● ● ● ● ● ●● ● ● ●●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ●● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ●●●●● ●● ●● ●● ● ●●● ● ●●●● ● ●●●● ● ● ● ● ● ●● ● ● ● ●●● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●●●● ●●●●●● ● ●● ● ●●●●● ●● ●● ●●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ●●● ● ● ● ● ●●● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ●●●● ●●● ● ●●● ●● ● ● ● ● ● ● ●●●●●●●● ● ● ● ● ●● ●●● ●● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ●● ● ●●● ●●●●●●● ● ● ● ● ●●●●●●●●● ● ● ● ● ●● ●●●● ● ● ● ● ● ●●●●● ● ● ● ● ●● ● ● ● ● ● ● ●●●● ●●● ●●●● ●●●● ●●●●●●● ●●●● ●●● ● ● ●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ●●● ● ●● ● ●● ●●●●●●●●●●● ● ● ●● ● ● ●● 0 0 (cM/Mb) Recombination rate GRIN2A

9800 9900 10000 10100 Chromosome 16 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.43.chr14

1 0.8 0.6 0.4 0.2 0.1

1 . rs2693698 : Schizophrenia(25056061)(5E−9) snp / p / or / maf / info / directions Schizophrenia(26198764)(1E−8) a . rs2693698 / 1.96e−08 / 0.95 / 0.45 / 0.985 / 15−42−0 8 Schizophrenia(28991256)(2E−8) 1 a p = 5.0e−08 ● 1 ●● ●● ●● ● ● ●● ● ●● ●● ● 40 ●● ● ●● ● ●●●● ● ●● ●● ●● ●● ● ● 6 ● ●●● ●● ●● ●● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ●● ● ● ●●

4 ●● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ●● 20 ●● ● ● Observed (−logP) ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● 2 ●● ●● ● ●● ● ● ● ● ● ● ● ● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ●● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ●●●● ●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ●● ●●● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ●● ●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ●●● ●● ●● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ●● ● ● ● ● ● ● ●●● ● ● ● ●● ●● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ●●●● ● ●● 0 0 (cM/Mb) Recombination rate BCL11B

99700 99800 Chromosome 14 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.18.chr6

1 0.8 0.6 0.4 0.2 0.1

1 . rs9371601 : Autism_spectrum...(23453885)(4E−9) snp / p / or / maf / info / directions 2 . rs1203233 : Bipolar_disorder(28072414)(4E−8) a . rs4331993 / 1.98e−08 / 1.06 / 0.38 / 1.000 / 43−13−1 8 a p = 5.0e−08 1 ●● ●● 40 ●● ●● ● ● ● ● ●●● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ●● ● ●● ●● ● ● ● ● ● ● ●●● ●● ● ● ● ● ● ● ●● ● ● ●● ● ●● ● ●● ● ● ●●●●●● ●●●● ● ● ● ● ●●●●●● ● ● ●● ● ● ●●● ●● 6 ● ● ●●●●●●● ●

● ● ● ● ●● ● ● ● ●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ●● ●●● ● ● ●●● ● ● ● ● ● ● ● ●●●●● ●● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● 2 ● ● ● ●●● 2 ● ●●

●● ● 4 ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ●● ● ● ● 20 ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● Observed (−logP) ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ●● ●● ● ● ●● ● ●●● ●● ●● ●●● ● ● ● ●● ●● ● ● ● ● ● ●● ●●●● ●● ● ● ● ●● ● ● ● ●● ●● ● ● ● ● ● ● ● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ●● ● ● ● ● ● ● ● ● ● ● ● 2 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ●●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ●●●●●●●●● ●●●● ●●● ●●● ●●●●●●●●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ●●● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ●●● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ●●● ● ●●●●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ●●● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ●● ● ●●● ●● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ●● ●●●●● ●● ●● ● ● ● ● ● ● ● ● ●● ● ●● ● ●●●● ●●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●● ● ● ● ●● ● ● ● ● ● ●● ● ●● ● ●● ● ● ● ● ● ● ● ●● ●● ● ●●●● ● ● ● ● ●● ● ●● ●● ● ●● ●● ● ● ●●● ● ● ● ● ● ● ●● ● ● 0 0 (cM/Mb) Recombination rate SYNE1

SYNE1−AS1

152700 152800 152900 Chromosome 6 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.58.chr22

1 0.8 0.6 0.4 0.2 0.1

1 . rs9607782 : Schizophrenia(28991256)(1E−12) snp / p / or / maf / info / directions Schizophrenia(25056061)(2E−11) a . rs5758064 / 2.01e−08 / 0.95 / 0.48 / 0.996 / 41−16−0 8 Schizophrenia(26198764)(2E−11) p = 5.0e−08 Autism_spectrum...(28540026)(9E−9) ●● a ●● 2 . rs743002 : Eosinophil_perc...(27863252)(2E−20) ●●●●

● 40 Eosinophil_perc...(27863252)(4E−19)●● ●● ● ● ●● ●● ● ● ● Eosinophil_counts(27863252)(9E−18) ● ● ● ● ● ●●●●●● ● ●●●● ●● 6 ●● ●● Neutrophil_perc...(27863252)(4E−12) ●● ●● ●● ● ● ● ● ● ●● ● Sum_eosinophil_...(27863252)(4E−10) ●● ● ● ● ●● ● ● ●● ● ●● ● 3 . rs9611519 : Neuroticism(29255261)(1E−10) ●● ● ●● ●● ●● Neuroticism(27918536)(9E−9) ●● ●● ● ● ● ●●● ● ●● ● ● ● ● ●● ●● ● ● ● ● ● ●● 4 ● ●● ●● ●● ● 4 . rs4820425 : Crohn's_disease(22936669)(3E−8)● ● ●● ● ● ● ● ●●● ● ● ●● ● ● ● ●● ●●● ● ● ●● ●● ●● ● ●● ● ● ●●●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ●● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●●●● ● ● ● ●●●● ●●●●●●●●●●● ●●●●● ● ● ● ● ● ●● ●● ● ● ● ●● ●●●● ●●●●●●●● ●● ● ● ● ●● ● ● ● ● ●● ●●●● ● ● ● ● ● ●● ●● ● ● ●● ● ● ●●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●●●●●●●● ●●●● ● ● ●●●● ● ●● ●● ●● ● ● ● ● ● ● ●● ●●●● ● ● ● ● ● ● ● ● ●● ● ●● ●● ●● ●● ●●● ● ● ● ● ● ●● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● 5 . rs2179744 : Major_depressive_disorder(27479909)(6E−11)● ●●● ●● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● 20 ● ● ● ●● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● Observed (−logP) ● ● ● ● ● ● ●● 1 ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● 1 ●● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ●●● ● ●●● ● ● Depressive_symptoms(29292387)(2E−8)● ● ● ● ● ● ● ● ● ●● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● 6 . rs2273085● : Neuroticism(29255261)(1E−17)● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ●●● ●● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ●● ●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ●●● ● ● ● ●● ●●●● ● ● ● ● ● ● ●●● ● ● ●● ● ● 2 ● ● ● ● ● ● 3 4 ●● ● ● ● 2● ● ●● ● ● 5 ● ● ● 4● 3 ● ● 5● ● 7 . rs9623320 : Major_depressive_disorder(29728651)(4E−8) ● 6 ● ● ● ● 7 ● ● ● ● ● ● ● 6 ● ●● 2 ● ● ●● ● ● ●● ●● ● 7 ● ● ● ● ● ● ● ●● ● ● 8 ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 8 ● ● ●● ● ● ● ● ● ● ●●● ● ● ● ● ●● ● ● ●● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ●●● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●●●●● ● ● ● ● ● ● ● ● ● 9● ● ● ● ● ● ● ● ● 8●●● . rs5758265 : Depressive_symp...(29292387)(1E−9)9●●●●●●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ●●●● ●● ● ● ● ● ● ● ● ● ●●● ● ●●● ●●●●● ● ●● ● ● ● ●● ●● ● ● ●● ● ● ●●● ● ● ●● ●● ●● ●● ●● ● ● ●●● ● ● ●● ● ● ● ● ● ● ●● ● ● ●●● ●●● ●●● ● ●●●●●● ● ● ● ● ● ● ● ●● ● ● ●●●●● ●● ●●●●●●●●●● ●●●● ●●● ● ● ● ●● ● ● ●●●●●● ● 10 ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● 10 ● ● ● ● 11 ● ● ● ● ● ● 11 ●● ● ● ● ● ● ● ● ● 12 ● ● ● ● 13● ● ● ● ● ● ● ● ● ● ● 12● ● ● ● 13●● ● ● ● ● ● ● ● ● Depression(29700475)(8E−9)● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ●●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ●● ● ● ● ● ●● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ●●●● ● ●● ●● ● ● ●●●● ● ● ● ● ●●● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● 9 . rs133047● ●: ●Schizophrenia(26198764)(7E−10)● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●●● ●● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ●●●●●●●●●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●● ●●●●● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ●●● ● ● ● ●● ● ● ● ●●● ●● ●●●● ● ● ● ●●● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ●● ● ●●●●●●●●●●●●●●●●●●● ●●● ●● ●●● ● ● ● ●●●● ●●●●●●●●● ● ●●●●● 0 1616 17Autism_spectrum...(28540026)(1E−8)17 1515 1414 0 (cM/Mb) Recombination rate 10 . rs6001982 : MRTFABreast_cancer(29059683)(1E−34) XPNPEP3 EP300 ......

MRTFA−AS1 MCHR1 DNAJB7 EP300−AS1

SLC25A17 RBX1 L3MBTL2

MIR4766 SNORD140 LOC100506544

ST13 MIR1281 CHADL

40800 40900 41200 41500 41600 Chromosome 22 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.4.chr2

1 0.8 0.6 0.4 0.2 0.1

1 . rs183034862 : Red_cell_distri...(27863252)(5E−14) snp / p / or / maf / info / directions a . rs13417268 / 2.05e−08 / 0.94 / 0.24 / 0.99 / 47−10−0 8 ● p = 5.0e−08 ● ● ● ●a ●● ●a ● ●● ● ●● ● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ●● ● ●● ● ● ● ● ● ●●● ● ● ● ● ● ● ●● 40 ●● ● ● ●

●● 6 ●● ●●

● ●●

●●

●● ●● 4 ●● ● ● ●● ● ● ● ● ● ● ● ●● ●● ● ●● ●●●●● ●●● ● ● ●● ● ●●●● ● ●● ●● ●●●●● ● ● ●● ● ● ● ● ● ● ● ● ● 20 ●● ● ● ● ●● ● ● Observed (−logP) ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ●●● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ●● ●●● ● ● ●● ● ● ●● ● ● ● ● ● ● ●● ● ●●● 2 ●● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ●● ● ● ● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ●●●● ●● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ●● ● ●● ● ● ● ● ● ●● ● ●● ●●● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ●● ●●● ●●●● ●●● ●●● ● ●● ● ● ● ● ●● ● ● ●● ●●● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ●●●● ●●●●● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ●● ●● ● ●● ●●● ●●●●●● ● ● ●●● ●● ● ● ● ● ● ● ●●●● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●●● ● ●● ● ●● ●● ● ● ●●●●●● ●● ● ● ● ● ●● ● ● ●●● ● ● ● ● ● ● ● ●● ● ●●● ● ●●●● ● ● ● ● ●● ● ● ●●● ● ● ● ● ● ● ● ● ● ●● ●● ●● ● ● ●● ● ● ● ● ●● ● ● ●●●●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●● ● ● ●●●●●●●●●●●● ● ●● ●● ● ● ●●● ●● ● ●● ● ● ● ● ●●● ●●● ●●●●● ● ● ● ●● ●●● ● ● ● ●● ● ●●●●● ● ● ●● ●● ● ● ● ● ● ● ●● 0 1 0 (cM/Mb) Recombination rate CERS6

MIR4774

169300 169400 169500 Chromosome 2 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.8.chr3

1 0.8 0.6 0.4 0.2 0.1

snp / p / or / maf / info / directions a . rs115694474 / 2.35e−08 / 0.94 / 0.20 / 0.993 / 13−44−0 8 ● p = 5.0e−08 ●● ●●●●●●a ● ● ● ● ●● ● ●● ● ●● ●●●●

● 40 ●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ●●● ● ● ● ● ●●●●● ● ● ●● ● ● ● ● ● ● ●● ● ● ●● ●● ● ●● ● ● ●● ●● 6 ●● ●● ●●

●● ●●

● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ●●● ● ● ● ● ●● ● ●● ● ● ●● ● ●●● ● ● 4 ● ● ● ● ● ● ●● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ●●● ●● ● ● ● ●●● ● ● ● ●● ● ● ● ● ● ● ● ● 20 ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● Observed (−logP) ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ●● ● ● ●● ●●● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●● ● ●● ● ● ● ● ● ● ● ● ●●● ● ● ●●●● ● ● ● ● ● ●● ● ●●● ● ● 2 ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ●●● ●● ●●●● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ●● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ●●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●●●● ●● ●●● ●● ●●●●●●● ● ● ● ● 0 0 (cM/Mb) Recombination rate

70400 70500 70600 Chromosome 3 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.30.chr9

1 0.8 0.6 0.4 0.2 0.1

1 . rs6476606 : Major_depressive_disorder(27479909)(1E−8) snp / p / or / maf / info / directions 2 . rs2988004 : Moderate_to_vig...(29899525)(4E−9) a . rs10973201 / 2.45e−08 / 1.10 / 0.11 / 0.799 / 14−41−2 8 3 . rs16933812 : Obesity−related_traits(22013104)(9E−9) a p = 5.0e−08

●● 40

● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●● ●●●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● 6 ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ●● ● ● ● ●● ● ●●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ●

●●● ● ● ●●● ●● ●●

4 ●●

●● ● 20 ● ● ●● ● Observed (−logP) ●● ●●

● ● ●● ●● ●● ● ●● ● ● ●● ●●● ●● ●● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● 2 ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ●● ● ● ●● ●●● 1 ●●●● ● ● ● ● ● ●● ●● ● ●●●●● ● ● ● ●●● 1 ● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ●●● ● ●● ● ● ●●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ●● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ●● ●● ● ● ● ● ●● ●● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●●●●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ●● ●●● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●●● ● 2 ● ● ● ● ● ●●●● ● ● ● 2● ● ● ● ●●● ● ● ● ● ●●● ●● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ●● ● ● ● ●● ● ● ●● ●● ●● ● ●● ● ● ● ● ●●● ● ● ● ● ● ●●●●●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ●●● ● ●●●●●●●● ● ● ●● ●● ● ● ● ● ●● ● ● ● ● ● ●●●● ● ● ●●●● ● ● ● ● ● ● ● ● ●●●●● ● ● ● ● ●●● ●● ●● ● ●● ●●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●●● ● ●● ● ● ●● ● ● ●● ● ●● ● ●●● ● ● ●● ●● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ●● ● ●●● ● ● ●●● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●●● ●●●●●●●●●● ●●●● ●●● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●●●●●●● ● ● ● ●●●●●●●●●●●●●●● ●●●●● ●●● ● ●● ● ●● ● ● ● ● ● ● ● ● ●●● ● ● ●● ●● ● 0 3 0 (cM/Mb) Recombination rate PAX5

EBLN3P

ZCCHC7

GRHPR

ZBTB5

37000 37200 37400 Chromosome 9 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.3.chr2

1 0.8 0.6 0.4 0.2 0.1

1 . rs353116 : Parkinson's_disease(28892059)(3E−8) snp / p / or / maf / info / directions 2 . rs3769955 : Febrile_seizures(25344690)(3E−10) a . rs17183814 / 2.68e−08 / 0.90 / 0.08 / 0.978 / 11−44−2 8 p = 5.0e−08 a ●● 40 6

●●

4 ●●

●● 20 ● Observed (−logP) ●● ● ● ●● ● ● ● ●● ●● ●● ● ●● ● ●● ● ● ●●●● ● ●●●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●●● 2 ● ● ● 1 ● ● ● 1 ● ● ● ●●● ● ● ● ● ● ●● ● ●●●●●●● ●●●●● ●●● ● ● ●●●● ● ● ●●●●●●●● ●● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ●●● ●●●● ● ● ● ● ● ●● ● ● ● ●● ● ● ●●●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ●● ● ● ● ●● ● ●●●●●●●● 2 ● ●● ● ● ● ●●● ● 2 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ● ●●● ●● ● ● ● ● ● ● ● ● ● ● ●●●●●●●● ●●●● ●●●●● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ●● ●●● ●● ● ● ● ● ● ● ● ● ●●● ● ● ●● ● ● ● ●● ●● ●● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ●●● ●●● ●●●● ●● ● ●●● ● ● ● ●●●●● ● ● ●●●●●●●● ● ● ●●● ● ● ● ● ● ● ● ●● ● ●● ●●●●●● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ● ● ●●● ●● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ●●● ● ● ● ● ● ● ● ● ●● ●● ● ●●● ●● ● ● ●●●●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●●●●● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ●●●● ●● ● ● ● ● ●● ● ● ● ● ● ●●●●●● ● ● ●● ●● ●● ● ● ●● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ●●● ● ● ●●●●● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ●● ●●● ●● ●● ● ● ● ● ● ● ● ● ● ● ● 0 0 (cM/Mb) Recombination rate SCN2A

CSRNP3

166100 166200 166300 166400 Chromosome 2 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.31.chr9

1 0.8 0.6 0.4 0.2 0.1

snp / p / or / maf / info / directions a . rs62581014 / 2.77e−08 / 1.07 / 0.37 / 0.694 / 44−11−2 8 p = 5.0e−08 ●● ●● a ● ●● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ●● ● 40 ●●

● ●● ●● ● 6 ●●

●●

●● ●●

●● ●● ●● ● 4 ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● 20 ●

Observed (−logP) ● ● ● ● ● ● ● ●● ●● ●● ● ● ●● ● ●● ●● ●●● ● ● ● ● ● ● ●● ● ● ● ● ● ● 2 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ●● ● ● ● ● ●● ●●●● ● ● ● ● ● ●● ● ● ● ● ● ● ● 0 0 (cM/Mb) Recombination rate CACNA1B

TUBBP5

LOC101928932

141000 141100 Chromosome 9 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.52.chr17

1 0.8 0.6 0.4 0.2 0.1

1 . rs5030755 : Mean_corpuscular_volume(27863252)(9E−11) snp / p / or / maf / info / directions a . rs4790841 / 3.14e−08 / 1.08 / 0.15 / 0.937 / 43−13−1 8 a p = 5.0e−08 ●● ●● 40

● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ● ● ● ● ● ● ●● ● 6 ●● ●● ●● ● ● ● ●●● ●● ●● ● ●●

●● ●● ●● ●● ●● ●●

●● ●● 4 ●● ● ●● ● ●●● ●●● ●● ●●● ● ● ● ● ●● ●● ● ●● 20 ● Observed (−logP) ● ●● ● ● ● ●● ●● ● ● ●● ●● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ●● ● ● 2 ● ● ● ● ● ●● ● ● ● ● ● ●●● ●● ● ●● ●● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ●● ● ● ●● ● ● ● ●● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ●●●●●●● ● ●● ● ●● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●● ●●●● ● ● ● ●● ● ● ● ● ● ●●●●● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●● ● ● ● ●● ●●● ● ●●● ●● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ●● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ●● ● ●●● ● ● ● ● ●● ● ● ●●● ● ● ● ● ● ●●● ● ● ● ●● ● ●●● ● ● ● ● ● ● ● ● ● ● ●● ●●● ● ● ● ● ●● ●● ● ●● ● ● 0 1 0 (cM/Mb) Recombination rate RPA1

RTN4RL1

1800 1900 Chromosome 17 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.40.chr11

1 0.8 0.6 0.4 0.2 0.1

1 . rs12290811 : Bipolar_disorder(24618891)(1E−9) snp / p / or / maf / info / directions 2 . rs12576775 : Bipolar_disorder(28115744)(3E−9) a . rs12289486 / 3.30e−08 / 1.09 / 0.11 / 0.996 / 41−16−0 8 Autism_spectrum...(23453885)(4E−8) p = 5.0e−08 Bipolar_disorder(21926972)(4E−8) ● ●● ●● ●● ● ● ●● ● ● ● ●●● ● ● a●● ●●●● ● ● ● ● ● ● ● ● ●●● ● ● ● ●● ● ● ● ●● ●● ● ● 40 ●● ●● ● ● ●●● ● ● ● ● ●●● ● ● ●●1● ● ● ●1●● ● ● ● ●● 6 ● ●● ●● ●

● ● ●● ●● ● ●● ● ●● ●● 2 ●● ● 2 ● ● ● ● ● ●● ● ● ●● ● ●

4 ●● 20 Observed (−logP) ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●●● ● ●● ● ● ●●●●●● ● ● ● ● ● ●●● ● ● ● ● ●●● ● ● ● ● ● ● ● ●● ● ● ● ●●● ● ● ● 2 ●● ● ● ● ● ● ●● ●●● ● ● ● ● ● ● ● ●● ● ●●●● ● ● ● ● ●● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ●●● ● ●●● ●●● ●● ● ● ● ● ● ● ● ● ● ●●● ● ●●●●●●●●● ●● ● ●●●● ● ●● ● ● ● ● ● ●● ● ●● ● ●● ● ● ● ● ●● ●● ● ● ● ●●● ● ●●●● ● ●●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ●● ●●● ●● ●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ●●●●●●● ● ● ● ● ● ●●● ● ●● ● ● ● ● ●● ●● ● ● ● ● ● ● ●●● ● ● ● ●● ● ● ● ● ●● ●●●● ●●● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ●●● ●●●●●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ●● ● ● ●●● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ●●● ● ● ● ●●● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ●● ● ● ●● ●● ● ●●●●● ●● ●●●●●● ● ● ● ● ● ● ● ● ● ● ●● ●●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●●●●● ● ●● ● ●● ●●● ● ● ● ● ●●● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ●● ● ● ●● ● ●●●●● ●●●● ●● ●●●● ●●●● ●● ●●●● ● ●● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ●● ●●●●●● ●● ● ● ● ●● ● ●● ●● ● ●●●● ● ●●●●●● ● ● ● ● ●●● ● ● ● ●● ● ●●●● ●●●●● ● ● ● ● ● ● ●●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●●● ● ●●●●●●●●●●●●●●●●●● ●●●● ●●●●●● ●●●●● 0 0 (cM/Mb) Recombination rate TENM4

MIR708

MIR5579

79000 79100 79200 Chromosome 11 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.25.chr7

1 0.8 0.6 0.4 0.2 0.1

snp / p / or / maf / info / directions a . rs6946056 / 3.65e−08 / 0.95 / 0.38 / 0.982 / 15−42−0 8 p = 5.0e−08

a ●● ●● ●● ●● 40 ●● ● ● ● ● ● ● ●● ●● ● ● 6 ●●

●● ● ●● ●● ●● ●● ● ●● ● ●● ● ● ● ● ● ● ● ●● ● ●● ●● 4 ●● ●● ● ● ● ● ● ●● ● ● ● ●● ●● ●● ●● ● ● ●● ● ●●● 20 ● Observed (−logP) ● ● ● ● ● ●● ● ●● ● ● ●● ● ● ● ● ●● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ●●●●●● ● ●●●●● ● ● 2 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ●●● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ●● ● ●● ●● ●● ● ●●● ●● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ●● ●● ● ● ●● ● ● ●● ● ● ●● ● ● ● ●●●● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●● ● ● ● ● ● ●●●●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ● ●● ●● ● ● ●● ●●● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ●●● ● ●●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ●●● ● ●● ●●● ● ● ●● ● ● ●● ● ●●● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ●● ●● ● ● ●●● ● ●● ● ●● ● ● ● ● ● ● ●●●● ● ●●●●●● ●●●● 0 0 (cM/Mb) Recombination rate PLXNA4

LOC101928807

131800 131900 Chromosome 7 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.14.chr5

1 0.8 0.6 0.4 0.2 0.1

1 . rs35131895 : Autism_spectrum...(28540026)(1E−8) snp / p / or / maf / info / directions 2 . rs3756766 : Schizophrenia(26198764)(2E−8) a . rs10043984 / 3.71e−08 / 1.06 / 0.24 / 0.985 / 41−16−0 8 3 . rs13164092 : Schizophrenia(28991256)(1E−9) 4 . rs3849046 : Autism_spectrum...(28540026)(2E−9) p = 5.0e−08 a ●● 1 ●● Schizophrenia(25056061)(5E−9)●● 1 ● ● ● ● ● ●●● Schizophrenia(26198764)(6E−9)2 ●●● 40 ●● 5 . rs17171818 : Menarche(9E−14) 6 6 . rs17599026 : Response_to_rad...(27515689)(4E−8) ● ●●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ●● ● ●●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● 3 ● ● 3 ● ● ● ● ●● ● ● ● ● ● ● ●● ● ●● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●● 4 ●● 4 ● ● ● ● 4 ●● ● ● ● ● ● ● ●●●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ●● ● ● ● ●● ● ●● ●● 20 ●● ●● Observed (−logP)

●● ● ● ● ●● ●● ● ●●

● ●● ●● ● ● ●● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ●●● ● ● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●●● ●● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ●● ●● ● ● ●● ● ● ● ● ● ● 2 ● ● ●● ● ● 5 ● ● ●● ● ● ● ● 5 ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ●●● ● ● ● ● 6 ● ● ● ● ● ● ● 6 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●● ● ●●●●●●● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ●●● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ●●●●●●●●●●● ●●●● ●●● ● ● ●● ●●●● ● ●● ● ●● ● ● ● ●● ●●●●● ●● ● ● ● ●● ● ● ● ●●● ●● ● ●●● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ●● ● ● ● ● ●●● ●● ●●● ●●● ● 0 0 (cM/Mb) Recombination rate CDC25C EGR1

LOC100128966 ETF1

FAM53C

KDM3B

REEP2

137700 137800 137900 Chromosome 5 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.44.chr15

1 0.8 0.6 0.4 0.2 0.1

1 . rs16967103 : Crohn's_disease(23128233)(4E−9) snp / p / or / maf / info / directions Chronic_inflamm...(26974007)(5E−9) a . rs35958438 / 3.83e−08 / 0.94 / 0.23 / 0.992 / 13−43−1 8 p = 5.0e−08

●● ● a ●● ●● 40 ●● ● ● ● ● ● ●●●● ● ●● ●●● ●● 6 ●●●●

● ● ● ●● ● ●● ●● ●● ●●● ●● ●● ●● ●● ●● ● 4 ●● ● ●●

● ● ● ●●● ● ●● ●● ● 20 ● ● ● ● ● ●● ●

Observed (−logP) ● ●●● ● ● ● ●● ●● ●● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●● ● ●● ●● ● ● ● ● 2 ● ● ● ● ●● ● ● ●●● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●●● ● ● ●●● ●●● ●● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ●● ● ● ● ● ● ●●●●●●●● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●● ● ● ● ● ●● ● ● ● ● ●●● ●●● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ●● ● ● ● ●● ● ●●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● 1 ●● ●● ● ● ● ● ● 1 ● ●● ● ●● ● ● ● ● ● ● ●●●● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ●●● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●●● ●●● ●● ● ● ● ● ● ●● ● ● ●● ●● ●●●●●● ●●●●●● ● ● ● ● ● ● ●●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ●● ●● ● ●●● ●●● ● ● ● ● ● ● ● ● ●●● ● ● ●●●● ●● ●●● ●● ●● ●● ● ●●● ●● ● ●●● ● ●● ● ● ● ● ● ● 0 0 (cM/Mb) Recombination rate C15orf53

38900 39000 Chromosome 15 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.32.chr10

1 0.8 0.6 0.4 0.2 0.1

1 . rs7893279 : Schizophrenia(28991256)(3E−13) snp / p / or / maf / info / directions Schizophrenia(25056061)(2E−12) a . rs1998820 / 4.10e−08 / 0.92 / 0.11 / 0.995 / 15−42−0 8 Schizophrenia(26198764)(6E−11) Autism_spectrum...(28540026)(3E−10) p = 5.0e−08 ●●●● ●● a 2 . rs2799573 : Autism_spectrum...(23453885)(4E−8) ● ●●● ● ●● ● ● ●● 40 3 . rs12258967 : Blood_pressure(21909110)(2E−16) ● ● ● ● ●●● ●● ● ● ● ● ● ●● ●● ● 4 . rs1813353 : Diastolic_blood_pressure(28739976)(4E−13)●● ● 1 ● ●● ●● 1 2 ● ● ● 6 Systolic_blood_pressure(28739976)(7E−9) ●● ●● ●●

● ● ● ● ● ● ● 5 . rs11014166 : Diastolic_blood_pressure(19430479)(1E−8) ●● ●● ●● ● ●● ● ● ●● 6 . rs1277723 : Body_mass_index(28892062)(2E−9) ● ● ● ●●● ● ● ● ● ● ●●● ● ● ● ● ● ● ●●●● ● ●● ● ●●● 7 . rs72786098 : Small_vessel_stroke(26732560)(2E−8)● ●●● ● ●● ●●●3 ●● ● ● 3 ● ● ● ● ●● ● ● ●● ●●● ●●● ● ●● ● ● ● ● ●●● ● ● ●●● 4 ● ● ● ●● 8 . rs7912454●● ● : Body_mass_index(28892062)(4E−10) ●● ● ● ● ●● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● 9 . rs7909027 : QRS_complex(4E−8) ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 20 ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● Observed (−logP) ● ●●●● ● ● ● ● ●● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ●● ● 4 ● ● ● ● ● 4 ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● 5● ●● ● ●● ● 5 ● ● ● ● ●● ● ● ●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● 2 ● ● ● ● ● ● ● ● ● ●●● ● ● ●● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ●● ● ● ● ●● ●● ● ● ● ● ● ●● ● ● ● ●● ●● ● ● ● ●●●●● ●● ●● ● ● ● ● ●● ● ● ● ●● ● ●●● ●●● ●● ● ● ● ● ●● ● ● ● ●● ●● ●● ● ●●● ● ●● ● ● ● ● ● ● ● ● ●●●● ● ●● ● ● ●●● ● ● ●● ●● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●●● ● ●●● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ●●● ● ●●●● ●● ●● ●● ● ● ● ● ●● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ●● ● ●● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ●●●● ●● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ●● ●● ● ●● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ●●● ●●● ● ● ● ● ● ● ●● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ●●● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ●●●● ● ● ● ●● ●● ●● ●● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ●●● ● ● ●●● ●● ●● ● ● ●● ●● ● ●● ● ●●●● ●● ● ●● ● 6 ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● 6 ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●●● ●● ●●● ●●● ● ●●● ● ● ●● ●● ● ● ●● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● 0 8 9 7 0 (cM/Mb) Recombination rate CACNB2

18600 18700 18800 Chromosome 10 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.5.chr2

1 . rs59979824 : Autism_spectrum...(28540026)(6E−9) snp / p / or / maf / info / directions Schizophrenia(25056061)(8E−9) a . rs2011302 / 4.25e−08 / 1.05 / 0.38 / 0.99 / 44−13−0 8 Schizophrenia(26198764)(2E−8) b . rs2719164 / 4.85e−08 / 0.95 / 0.44 / 0.996 / 43−14−0 2 . rs12619354 : Schizophrenia(28991256)(4E−8) p = 5.0e−08

● ●● ● ●● ●●● a ● ● a ● ● ● ● 3 . rs1596747 : Educational_att...(27225129)(1E−9)● ●●●●● ● b ● ● ● ● b●●● ● ● ● ●● ● ● ● ● ●● ● ●● ● ● ● ● ● ●● ●● ● ● ● 40 ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●● ● ●● ●●●●●●●● ● ● ●●●● ●●●●● ●● ●● ● ●● ● ● ●● ●● ● ●● ●● ● ● ● 6 ●

● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● 1 ● ● 1 ● ● ● ●●● ●●● ● ● ●● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ●●●● ●●●●● ●● 2 ● ●● ● ● ● ●● ●●● ● ●●● ●● ● ●● ●●● ● ●● 2● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ●●● ● ● ● ●● ● ●●● ●●●● ● ● ● ● ● ●● ●●●● ● ●● ● ●●● ● ● ● ● ● ●●●●●●●●●●● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ● ● ● 4 ● ●● ●●● ●● ● ●●●● ● ●● ● ● ● ●●● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ●●● ●●●●●●●●●● ● ● ● ● ● ● ●●●●●● ● ●●●● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ●●●● ●●● ● ● ●● ●● ● ● ● ● ●●● ● ● ●●● ●●● ●●● ● ● ● ● ● ● ●●●●● ● ● ● ● ●●●●●● ● ●●●● ● ● ● ● ● ● ●●● ●●●● ●● ●● ● ● ● ●●●●●● ● ● ● ● ●●●●● ●● ● ● ● ●●● ●●● ● ● ● ● ● ● ● ●● ● ●● ●●●● ●●● ● ● ● ● ●●●●●● ● ●●●● ●●●●●●● ●● ● ● ● ● ● ● ●●● ●● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ●●●●● ● ● ● ● ●● ●●● ● ●● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ●●●●●●●●●●●● ● ●● ● ● ● ● ● ●●●●● ● 20 ● ● ● ● ● ● ●● ● ● ● ● ● ●●●●● ● Observed (−logP) ●●●●●●●●● ●● ●●● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ●● ●●●● ● ● ●●●●● ●●●●●●●● ● ● ● ●●●● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ●● ● ●●● ●●● ● ●● ●●● ●● ●●● ● ●● ●● ● ●● ● ● ● ● ● ●● ● ●● ● ●●● ● ● ● ● ● ● ● ● ● ●●● ● ●● ●●●●●● ● ● ● ●● ●●● ● ● ●● ● ● ● ● 3● ● ●● ●●●● ● ●●● ●● ● ● ● ● ●● ● ● ● ● 3 ● ●●● ● ● ● ● ● ● ●● ● ● ● ●●●●●●●●●● ● ● ● ● ● ● ● ● ● ● ●●● ●● ●● ●●●● ● ● ● ● ● ● ●●●●●● ● ●●●●●●●●●●● ● ●●●● ● ● ● ● ● ● ● ● ● ● ●●●● ●●●●●●●●●●●● ● ● ●●●●● ● ● ●●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ● ● ● ●●●●●●● ● ● ● ●●● ● ● ● ● 2 ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ●●●● ● ● ● ● ● ● ● ● ● ● ● ●

filter: p < 0.05

0 0 (cM/Mb) Recombination rate PCGEM1

193400 193600 194100 194600 194800 Chromosome 2 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.9.chr3

1 0.8 0.6 0.4 0.2 0.1

snp / p / or / maf / info / directions a . rs696366 / 4.46e−08 / 0.95 / 0.45 / 0.986 / 11−46−0 8 p = 5.0e−08

● a ● ●● ● ●● ● ● ●● ●● 40

● ●● ● ●● ● ● ● 6 ●● ●

● ● ●●●● ● ●● ● ●● ●●● ● ●●●●● ● ● ●● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ●● ● ●●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●● ● ● ●● ● ●● ●● ● ●●● ● ● ● ● ● ● ● 4 ● ● ● ●● ● ●● ● ● ● ● ● ●● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● 20 ● ● ● ●● ●●●●● ●● ● ● ●● ●●● ● ●●●●●●●●●●●●●●●●●●●●●●●●●●●● ●● ● ● ● ●●● ●●●●●●●●●●●●●●●●●● Observed (−logP) ● ● ●●●●●● ●● ● ● ● ●●●●●●●●●●●●●●●●●●●●●●● ● ●●●●●●●●●●●●●● ●●●●●●●●●●● ● ● ● ● ● ●● ●●●● ●●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ●● ●●●● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ●● ●●●●●●●● ● ●● ● ● ● ● ● ● ● ● ● ● ●●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● 2 ● ● ● ●● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●●●● ●● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ●● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ●●● ● ●● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ●● ● ●● ● ● ● ● ● ● ● ● ●●● ●● ● ● ● ●● ● ● ●● ●● ● ● ● ● ●● ●● ● ● ● ●● ● ● ● ●● ●● ● ● ● ● ● ●● ● ● ●● ●● ●● ● ●● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ●● ● ●● ●●● ● ● ●●● ● ● ● ●● ● ● 0 0 (cM/Mb) Recombination rate CD47

LINC01215

IFT57

107700 107800 107900 108000 Chromosome 3 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out bip_pgc3.34.chr10

1 0.8 0.6 0.4 0.2 0.1

1 . rs10822050 : Pediatric_autoi...(26301688)(8E−11) snp / p / or / maf / info / directions 2 . rs10995271 : Chronic_inflamm...(26974007)(3E−48) a . rs10761661 / 4.65e−08 / 1.05 / 0.47 / 0.995 / 40−17−0 8 Crohn's_disease(18587394)(4E−20) 3 . rs10995251 : Atopic_dermatitis(23042114)(6E−20) p = 5.0e−08 4 . rs16917546 : Eosinophil_counts(29403010)(4E−10) a

●● ●● 40 5 . rs10995240 : Eosinophil_counts(27863252)(1E−32) ●●● ●● ●● ● ●● ● ● ● ●●● ● Sum_eosinophil_...(27863252)(5E−32)● ● ● ● ●● ● ●

● ● ●●● 6 ● ●●● ●● ● ●● Eosinophil_perc...(27863252)(6E−28)● ● ● ●● ● ● ● ● ● ● ● ● ● ●● 1 ● ● ●● ● ● ● 12 ●● ● ● 3●● ● ● 2 ● ● ● ● ● ● ● ● 3● ● ●●4● ● ●●● Eosinophil_perc...(27863252)(3E−26)4 ●● ● ● ●● ● ● ● 5 ● ● ● ●● ● ● ● ● 5 ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● Neutrophil_perc...(27863252)(3E−25) ● ● ● ● ● ●●●● ● ● ●●●●●● ● ● ● ● ● ●●● ● ● ● ● ●●● ●● ● ●●● ●● ● 6 . rs224278 : Ewing_sarcoma(22327514)(4E−17) ● ● ● ● ● ● ●● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ●●●● ● ●● ● ● ● ● ● ● 6 ● ● ● ● ● ● ●● ● ● ● ● ● 6 ● 4 ●●●● ●● 7 . rs224090 : Crohn's_disease(26192919)(4E−26) 7 ● ● ● ● ● ● ● ● ● 8 ● ●● 7 ● ● ● ● ● ● ● ● ●● ● ●● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ●● ● ●● ● ● ●● ● ● ● ● ●● ● ●● ● ● ● ● ● ●● ●●● ●●● ●● ●●●●● ● 8 . rs442309 : Vogt−Koyanagi−H...(25108386)(3E−11)●● ●● ●●●● ●● 20 ● ● ● ● ●● ● ● ● ● ●●

Observed (−logP) ● 9 ●● 9 ● ● ● ● ● ● ● ● ● ● ● ● ● 9 . rs61865900 : Breast_cancer(29059683)(2E−9) ● ● ●● ● ● ● ● ● ●● ●● ● ● ● 10 ●● ● ● ● ● ● ●● ● ● ● ● ●● ● ● 10 ● ● ● ● ● ● ●●●● ● ● ● ● ● ●● ● ● ● ● 10 . rs10995311 : Diastolic_blood_pressure(27618447)(1E−12) ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ●● ●●● ● ● ●● ● ●● ● ●● ●● ● ● ● ● ●● ●●● ●●● ●● ● ●● ● ● ● ● ● ● ● ● ● ...... ●● ● ● ● ● ● 2 ● ●● ● 11●● ● ● ● ●● ● ● 11 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● 12 ● ● ●●● ●● ● ● ● ● 13 12 ●● ● ● 13 ● ● ● ● ● 14 ● ● ● ● ● ● ● ● 14 ● ● ● ● ●● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●●●●● ● ●●● ● ● ● ● ● ● ●●●●●●● ● ●●● ● ● ●● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ●●● ● ● ● ● ●●● ● ●● ● ● ● ●● ● ● ● ● ● ●● ● ●●●●● ● ● ● ● ● ● ●● ●● 15● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● 15 ● ●● ● ●●● ●● ● ● ●● ● ● ● ● ● ● ● ●●● ●●●●● ● ● ● ● ● ● ●● ●● ● ● ● ●● ●●● ● ● ●●● ●● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ●●● ● ●●●● ●●●● ●●●●●●●● ●●●●● ●● ● ● ●●● ● ● ● ● ● ● ●●●●●●●●●●●●●●●● ● ● ● ● ● ● ●● ● ●● ● ●● ● ● ● ● ● ● ●●●● ● ● ● ● ● ●● ● ● ● ●●●● ● ●● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ●16 ● ● ● ● ●● ●●● ● ● ● ● ● ●● ●●● ● ● ● ● ●● 16 ● ●● ● ● ●●● ● ● ● ● 17 ● ● ● ● ● ●● ● ● ●●● ● ● ● ● ● ● ● ● ● ● 18● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● 17 ● ●● ●● ● 19● ● ● ● ● ● 18 ● ● ● ●● ● ●● 19 ● ● ● ● ● ● ●●● ● ● ● ● ● ●●●● ● ●● ● ●● ● ● ● ● ● ● ●● ● ● ● ●●● ●● ● ● ● ●●● ● ●●● ●●● ● ● ● ● ● ● ● ●● ● ● ●●● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●●● ● ●●● ●● ● ●● ● ●●● ●● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ●● ●● 0 2121 2020 0 (cM/Mb) Recombination rate ZNF365

ADO

EGR2

64400 64500 64600 64700 Chromosome 10 (kb) database: gwascatalog.Sep_2018.rp.txt, refGene.txt.Sep_2018.out