COPPER BIOAVAILABILITY and METABOLISM ADVANCES in EXPERIMENTAL MEDICINE and BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo IRUN R
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COPPER BIOAVAILABILITY AND METABOLISM ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo IRUN R. COHEN, The Weizmann Institute of Science DAVID KRITCHEVSKY, Wistar Institute ABEL LAJTHA, N. S. Kline Institute for Psychiatric Research RODOLFO PAOLETTI, University of Milan Recent Volumes in this Series Volume 252 DRUGS, SYSTEMIC DISEASES, AND THE KIDNEY Edited by Alberto Amerio, Pasquale Coratelli, Vito M. Campese, and Shaul G. Massry Volume 253A PURINE AND PYRIMIDINE METABOLISM IN MAN VI, Part A: Clinical and Molecular Biology Edited by Kiyonobu Mikanagi, Kusuki Nishioka, and William N. Kelley Volume 253B PURINE AND PYRIMIDINE METABOLISM IN MAN VI, Part B: Basic Research and Experimental Biology Edited by Kiyonobu Mikanagi, Kusuki Nishioka, and William N. Kelley Volume 254 MECHANISMS OF LYMPHOCYTE ACTIVATION AND IMMUNE REGULATION II Edited by Sudhir Gupta and William E. Paul Volume 255 CALCIUM PROTEIN SIGNALING Edited by H. Hidaka Volume 256 ENDOTOXIN Edited by Herman Friedman, T. W. Klein, Masayasu Nakano, and Alois Nowotny Volume 257 THE IMMUNE RESPONSE TO VIRAL INFECTIONS Edited by B. A. Askonas, B. Moss, G. Torrigiani, and S. Gorini Volume 258 COPPER BIOA VAILABILITY AND METABOLISM Edited by Constance Kies Volume 259 RENAL EICOSANOIDS Edited by Michael J. Dunn, Carlo Patrono, and Giulio A. Cinotti A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher. COPPER BIOAVAILABILITY AND METABOLISM Edited by Constance Kies University of Nebraska Lincoln, Nebraska PLENUM PRESS • NEW YORK AND LONDON Library of Congress Cataloging in Publication Data American Chemical Society Symposium on Copper Bioavailability and Metabolism (1989: Dallas, Tex.) Copper bioavailability and metabolism / edited by Constance Kies. p. cm. - (Advances in experimental medicine and biology; v. 258) "Proceedings of the American Chemical Society Symposium on Copper Bioavailabili- ty and Metabolism, held April 9-14, 1989, in Dallas, Texas" - Verso of Lp. Includes bibliographical references. ISBN -13 :978-1-4612-7855-9 e-ISBN -13 :978-1-4613-0537-8 DOl: 10.1007/978-1-4613-0537-8 I. Copper - Bioavailability -Congresses. 2. Copper - Metabolism - Congresses. I. Kies, Constance. II. Title. III. Series. QP535.C9A44 1989 89-22994 612.3'924-dc20 CIP Proceedings of the American Chemical Society Symposium on Copper Bioavailability and Metabolism, held April 9-14, 1989, in Dallas, Texas © 1989 Plenum Press, New York Softcover reprint of the hardcover 1st edition 1989 A Division of Plenum Publishing Corporation 233 Spring Street, New York, N.Y. 10013 All rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher PREFACE Nutrition is truly a science of the 20th century. That physiological disabilities could be caused by a lack of exogenous substances which could be supplied by foods is a concept of relatively recent origins. It is not surprising, therefore, that, until the last few years, much of nutritional science research was tied to: 1) establishing a cause and effect relationship between a physiological problem and its cure/prevention by a chemical substance in food; 2) quantifying the amount of the substance (nutrient) needed to prevent deficiency symptoms; and 3) quantifying the amounts of nutrients found in various food substances. That a nutrient might be present in apparently adequate amounts in foods consumed by an individual but could not be fully utilized because of the concurrent consumption of anti-nutrients has been recognized as being an important problem as, for example, iodine-deficiency goiters resulting from consumption of gOitrigens. That less specific, less dramatic interactions among nutrients and among nutrients and other food components might enhance or inhibit the absorption of nutrients from the intestines or of the metabolism of nutrients within the body is an area of current concern. The Agriculture and Food Chemistry Division of the American Chemical Society in recognition of the importance of bioavailability, bioutilization and metabolism of mineral nutrients has been sponsoring a series of symposiums with the objective of bringing together established research scientists and investigators at the start of their careers. By so doing, current information can be defined and future research directions can be illustrated. This volume is the result, in large part, of the efforts of the participants of the most recent of these symposiums, i.e. Bioavailability and Metabolism of Copper. The editor would like to thank Mrs. Donna Hahn for her efforts in helping to organize the American Chemical Society symposium in which the oral versions of many of the chapters included in this book were first presented as well as her technical assistance making this volume become a reality. Constance Kies Editor v CONTENTS Introduction . • • . • • • • • • • • • • • • • •• xi COPPER IN FOODS AND FACTORS AFFECTING ITS AVAILABILITY Food Sources of Dietary Copper C. Kies Stable Isotope Studies of the Effect of Dietary Copper on Copper Absorption and Excretion • . • • • • • 21 J.R. Turnlund Influence of Ascorbic Acid, Zinc, Iron, Sucrose and Fructose on Copper Status . • . 29 M.A. Johnson Copper Absorption as Affected by Supplemental Calcium, Magnesium, Manganese, Selenium and Potassium • • 45 C. Kies and J.M. Harms The Type of Dietary Carbohydrate Consumed During Pregnancy and Lactation Determines Copper Status of the Fetus and the Neonate Rat • . • • • . 59 M. Fields, C.G. Lewis and T. Beal Factors Affecting Copper Absorption in Humans and Animals 71 P.E. Johnson Inhibitors of Copper Bioutilization: Fiber, Lead, Phytate and Tannins • • • . • 81 C. Kies and J. Umoren COPPER ABSORPTION AND TRANSPORT Copper Transport: Insights into a Ceruloplasmin-Based Delivery System • • • . • • • • • • • • . • • • 95 E.D. Harris and S.S. Percival The Biodistribution of Radiocopper-Labeled Compounds . • • . • • 103 J.A. Mercer-Smith, D.A. Cole, J.C. Roberts, D. Lewis, M.J. Behr and D.K. Lavallee vii Metalloforms of Metallothionein Induced by Parenteral Copper: The Influence of Route of Administration • • • • • • • • • • • • 123 C.C. McCormick, L.-Y. Lin and J.C. Fleet Mechanism of Copper Transport and Delivery in Mammals: Review and Recent Findings • • •• •••••••••••.•• 131 C.A. Goode, C.T. Dinh and M.C. Linder COPPER METABOLISM AND PHYSIOLOGICAL EFFECTS Copper and Zinc Status in Moderate Alcohol Intake ••••. 145 N.A. Frimpong and J. Louis-Charles Effect of Estrogen on Serum and Tissue Levels of Copper and Zinc . • • 155 S.W. Mehta and R. Eikum Effects of Exercise Training on Human Copper and Zinc Nutriture . • • 163 H.C. Lukaski Serum Total Cholesterol and HDL-Cholesterol Levels as Associated with Copper and Zinc Intake in Physically Active And Sedentary Elderly Men and Women •••.•.••...••••• 171 J. Umoren Modulation of Long Chain Fatty Acid Unsaturation by Dietary Copper • • 183 S.C. Cunnane Ischemic Heart Disease as Copper Deficiency • . • • • • • • • • • • • 197 L.M. Klevay Copper Complexes Stimulate Hemopoiesis and Lymphopoiesis . • . • . 209 L.S.F. Soderberg, J.B. Barnett and L.R.J. Sorenson Exocrine Pancreatic Function of Rats Consuming a High-Fructose, Low-Copper Diet • • • •• •.•••••.••. 219 C.G. Lewis and M. Fields Bioavailable Copper Complexes Offer a Physiologic Approach to Treatment of Chronic Diseases . • . • . • . •• .••••• 229 J.R.J. Sorenson, S.F. Soderberg, M.V. Chidambaram, D.T. de la Rosa, H. Salari, K. Bond, G.L. Kearns, R.A. Gray, C.E. Epperson and M.L. Baker Changes in Serum Copper and Zinc During Treatment with Anticancer Drugs Interfering with Pyridoxal Phosphate • • • • . 235 M. Slavik, T.R. Narasimhan, C. Riley and J. Slavik Effect of Copper on Immune'Function and Disease Resistance ..•••• 243 J.R. Stabel and J.W. Spears Effects of Inflammation on Copper Antioxidant Enzyme Levels • . • . • 253 R.A. DiSilvestro Copper-67 Labeled Porphyrin Localization in Inflamed Tissues • . • . • 259 D.A. Cole, J.A. Mercer-Smith, J.K. Norman, S.A. Schreyer, K.P. Bullington, J.C. Roberts and D.K. Lavallee Serum Copper Concentration as an Index of Clinical Lung Injury . • • • 273 A. Molteni, W.F. Ward, Y.T. Kim, R. Shetty, L. Brizio-Molteni, R. Giura, H. Ribner and M. Lomont viii Serum Copper Concentration as an Index of Experimental Lung Injury • • • • • • • • • • • • • • • • • • . • • • • • • • • 287 W.F. Ward, A. Molteni, C. Ts'ao and H. Ischiropoulos Index ••••••••••••••••.•••.••••••.••••• 303 INTRODUCTION Constance Kies Department of Human Nutrition and Food Service Management University of Nebraska Lincoln, NE The usefulness of copper to people dates back to antiquity (Adriano, 1986). It was one of the first metals used by humans. The discovery of hardening of copper by alloying it with tin to form bronze marked the end of the stone age. Currently, about half of the world production of copper is used in electrical equipment but its alloys are used in plumbing, piping and a wide variety of other products. In addition, copper compounds are used as fungicides and herbicides, insecticides and bactericides, preservatives, pigments in paints and ceramics, algicides, food and feed additives and fertilizers (Adriano, 1986; Kutsky, 1981).