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(12) Patent Application Publication (10) Pub. No.: US 2003/0152588 A1 Huang Et Al

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(12) Patent Application Publication (10) Pub. No.: US 2003/0152588 A1 Huang Et Al US 2003O152588A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2003/0152588 A1 Huang et al. (43) Pub. Date: Aug. 14, 2003 (54) CHINESE TRADITIONAL MEDICINES FOR Publication Classification PSORASIS 51) Int.nt. Cl.C.7 ........................ A61K 35/78; A61K 31/404 (76) Inventors: Hsu-Shan Huang, Taipei (TW); Rong (52) U.S. Cl. .................... 424/195.18; 424/759; 424/748; Fu Chen, Taipei (TW) 424/773; 424/778; 424/756; 424/746; 514/.414 Correspondence Address: DYKAS, SHAVER & NIPPER, LLP (57) ABSTRACT PO BOX 877 BOISE, ID 83701-0877 (US) The invention relates to disclose Some Chinese formula for pSoriasis. Whether treatment for psoriasis is targeted at both (21) Appl. No.: 10/050,060 the hyperproliferative and inflammatory aspect of the topical therapy. Specially, the administration dosage is Soft gel, (22) Filed: Jan. 14, 2002 cream, tincture and aeroSol etc. topical dosages. US 2003/0152588 A1 Aug. 14, 2003 CHINESE TRADITIONAL MEDCNES FOR 0008. It is well know that CTMs are compound medi PSORASIS cines, which are combined with various crude drugs, and the exhibition of their pharmacologic activity is the result of the DESCRIPTION pharmacodynamic interaction of the combined drugs and their components. Zhonghua Bencao have State Radix Trip BACKGROUND OF THE INVENTION terygiim Wilfordii 1 is the plant of Tripterygium wilfordii Hook. f., have containing Some alkaloids, diterpene, triter 0001) Field of the Invention pene ingredients, Such as Wilfordine, Tripterin, Triptolide, 0002 The invention relates to disclose some Chinese Tripdiolide, Triptonide, Celastrol, Tripterifordin, Triptofor formula for psoriasis. Whether treatment for psoriasis is din A-G, Triptogelin A, Triptogelin B, Triptogelin C and targeted at both the hyperproliferative and inflammatory C, Triptogelin D, Triptogelin E, Triptogelin G, Trip aspect of the topical therapy. toquinone A-G, Triptonoterpen, Neotriptonodiol, Triptono 0003) Psoriasis is a widespread, inflammatory and scaling diol, Neotriptonolide. skin disease, which is characterized by abnormal kerati 0009 Caulis Spatholobi 2 is the plant of Spatholobus nocyte proliferation and differentiation of the epidermis, SuberectuS Dunn have containing Some Fridelan-3?-ol, dau accumulation of polymorphonuclear leukocytes in the skin. costerol, B-Sitosterol, 7-OXO-B-sitosterol, formononetin, Ono Dominant and interdependent features of psoriasis are epi nin, prunetin, 9-methoxycoumeStrol, medicago, afromosin, dermal hyperproliferation, disturbed keratinocyte differen 3,7-dihydroxy-6-methoxy-dihydroflavonol, chalcone, proto tiation, and inflammation of the dermis and epidermis. catechuic acid, epicatechin, licochalcone A, isoliquiritige nin, 5C.-StigmaStane-3,3,6C.-diol, 2',4',3,4-tetrahydroxy daid 0004. However, the etiology of this very distressing skin Zein, Stigmast-5-ene-3f,7C.-diol, cajanin. disorder is unknown. The treatment for psoriasis is targeted at both the hyperproliferative and inflammatory aspect of the 0010 Radix Angelicae Sinensis 3 is the plant of Angeli topical therapy. Miller K, et al., J Med Chem. 39, 3132-8, cae Sinensis (Oliv.) Diels have containing essential oil, 1996 has reported some dihydroxy-9(10H)-anthracenones nicotinic acid, butylidene phthalide, n-Valerophonone-O- that have inhibited keratinocyte growth, 5-lipoxygenase, and carboxylic acid, carvacrol, phenol, ocreSol, p-creSol, guai the formation. acol, 2,3-dimethylphenol p-ethylphenol, isoeugenol, m-eth ylphenol, 4-ethylresorcinol, 2,4-dihydroxy-acetophenone, 0005 Current treatment for psoriasis may be topical or Vanillin, ligustilide, adenine, myrcene, C-pinene, B-Ocimine systemic. Miller K., Curr. Pharm. Design, 6,901-18, 2000 X, alloocimine, bicycloelemene, cadinene, 6-n-butyl-1 has reported indications for Systemic treatment are failure to 4-cycloheptdiene, 2-methyldodecan-5-one, copaene, 1 respond to topical treatment and Severe or life-treatening ,5-trimethyl-2-formyl cyclohexa-2,5-diene-4-One, acoradi forms of psoriasis. ene, uracil, acetophenone, -bisabolene, isoacoradiene, ber 0006 Müller K and Huang HS., Chin Pharm J. 48, gamotene, brefeldin, eucarvonel, threonine, Senkyunolide, 337-54, 1996 have suggested the biological activity of drugs 3,4-dimethyl-benzaldehyde, trans-B-farnesene, Y-elemene, useful as antipsoriatic agents may be evaluated by their n-butylphthalide, n-butylidenephthalide, Safrole, leucine, antiproliferative activity in cell cultures and antioxidative camphoric acid, azelaic acid, Sebacic acid, myristic acid, activity in vitro, Since there is no appropriate animal model phthalic 6-methoxy-7-hydroxycoumarin, anhydride, C.-ce of pSoriasis. drene, Vanillic acid, p-ethyl-benzaldehyde, Verbenone, 2,4, 6-trimethylbenzaldehyde, angelicide, B-Selinene, 1-tetrade 0007 CTMs (Chinese traditional medicines) have been extensively used to treat psoriasis and have acquired con canol, B-sitosterol, daucosterol, palmitic acid, Succinic acid. siderable favor among many of the patients. The earliest ferulic acid, cuparene. description of psoriasis in ancient Chinese medical literature 0011 Rhizoma Smilacis Glabrae 4 is the plant of Smilax may be found in Sui-Dynasty, 581-618 AD. According to glabra Roxb. have containing tannin, Saponin, resin, astil Chinese literatures “Bian Zheng Shi Zhi ", Lin X R. J. bin, engeletin, 3-O-caffeoylshikimic acid, Shikimic acid, Dermato. 20, 746-55, 1993 collected a number of clinical ferulic acid, B-sitosterol, quercetin, kaempferol. pSoriasis caseS report, and distinguished pSoriasis into 2 or 0012 Rhizoma Sparganii 5 is the plant of Sparganium 3 types, namely “Blood-Heat' type and “Blood deficiency Stoloniferum Buch.-Ham. have containing benzeneethanol, Dryness” type or “Blood-Heat”, “Blood deficiency-Dry dehydrocostuslactone, hexadecanoic acid, 1,4-benzenediol, ness” and “Blood stasis type. While in also described B-elemene, 2-furanmethanol, 2-acetylpyrrole, Stigmasterol, prescription (I) to treat “Blood-Heat' type, that including 1-hydroxy-2-acetyl-4-methylbenzene, 9-octadecenoic acid, Caulis Spatholobi 2, Radix Rehmanniae Exsiccata 6, Radix Lithospermi 13, Radix Salviae Miltiorrhizae 14, Radix 3-phenyl-2-propenoic acid, formonetin, B-sitosterol, Paeoniae Veitchii 17, Rhizoma Imperatae 23, and Flos 11-eicoSenoic acid, decanedioic acid, benzoic acid, azelaic Sophorae 27. Prescription (II) to treat “Blood deficiency acid, 3,4-dihydro-8-hydroxy-3-methyl-1H-2-benzopyran-4- Dryness” type that including Caulis Spatholobi 2, Radix one, daucosterol, Succinic acid, Sanleng acid, 9,11-octadeca Angelicae Sinensis 3, Rhizoma Smilacis Glabrae 4, Radix dienoic acid, 9,12-octadecadienoic acid, 9-hexadecenoic Rehmanniae EXSiccata 6, Radix Ophiopogonis Japonici 7, acid, 19-nonadecenoic acid. Radix Asparagi 8, Nidus Vaspae 10, and Radix Salviae 0013 Radix Rehmanniae Exsiccata 6 is the plant of Miltiorrhizae 14. Prescription (III) to treat “Blood stasis” Rehmannia glutinosa (Gaertn.) Libosch. Ex Fisch. et Mey. type that including Canlis Spatholob. 2, Rhizoma Sparganii have containing Leonuride, rehmannoSide A-D, ajugol, 5, Herba Hedyotis 11, Rhizoma Curcurinae Aeruginosae 15, aucubin, melitto Side, rehmaglutin A-D, acteoside, isoacteo Pericarpium Citri Reticulatae 18, Flos Carthami 19, Semen Side, monometittosid, geniposide, ajugoside, 6-O-E-feruloy Amygdalus Persicae 20, and Ramulus Euonymi 26. lajugol, jioglutin D-E, jioglutoSide A, jioglutolide, 6,8- US 2003/0152588 A1 Aug. 14, 2003 dihydroxyboSchnialactone, echinacoside, cataepolgenin, tetrahydrotanshinone I, B-sitosterol, methylene grardoside, Mioporosidegenin, rehmaionoside A-C, reh tanshiquinone, dihydrotanshinquinone, dansheXinkum A-D, mapicroSide, purpureaside C, JionoSide A1, Jionoside B1, tanshindiol A-C, miltirone, A-dehydromiltirone, 4-methyl cistanoside A, cistanoside F, glutinoside, Some organic acid. enemiltirone, militionone I-II, Salvilenone, tanshinlactone, dihydrotanshinlactone, urSolic acid, danshenspiroketallac 0.014 Radix Ophiopogonis Japonici 7 is the plant of tone, epidanshenspiroketallactone, cryptoacetalide, epicryp Ophiopogon japonicus (L. f.) Ker-Gawl. have containing toacetalide, Salvinone, Salviolone, militiodiol, militipolone, linalool, ruscogenin, ophiopogonin B, ophiopogonin D, jas norSalvioxide, ferruginol, Saiviol, Sugiol, Salvianic acid A-C, mololone, (23S, 24S, 25S)-23, 24-dihydroxyruscogenin, D(+)-?3-(3,4-dihydroxyphenyl) lactic acid, Salvianolic acid, methylophiopogonanone A-B, Ophiopogone A, ruscogenin roSmarinic acid, methyl roSmarinate, monomethyl lithoSper l-O-Sulfate, terpinen-4-ol, glycerol, longifolene, cyperene, mate, dimethyl lithoSpermate, ethyl lithoSpermate, lithoSper guaiol, mic acid B, protocate chualdehyde, isoferulic acid, baicalin, 0.015 Radix Asparagi. 8 is the plant of Asparagus 5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy4-hydroxy cochinchinensis (Lour.) Merr. have containing methylpro phenyl)-3-benzobfurancarbaldehyde, daucosterol, tigoge todioScin, pseudoprotodioScin, yamogenin, diosgenin, Sar nin, isoimperatorin. Sasapogenin, asparagus polysaccharide A-D, oligosaccha 0022 Rhizoma Curcumae Aeruginosae 15 is the plant of ride I-VII, Smilagenin. Curcunae aeruginosae Roxb. have containing essential oil, 0016 Olibanum 9 is the plant of Boswellia carterii Birds Sesquiterpenoid Such as, curZerenone, borneol, germacrone, have containing C, B-boSWemc acid, olibanoresene, pinene, curcumene, camphene, limonene, 1,8-cineole, tur O-acetyl-B-boSWellic acid, thujone, dihydroroburic acid, merone, terpinene, isoborneol, caryophylene, caryophyl epilupeol acetate, tirucallol,
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