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2011 PSNA 50Th Anniversary Meeting, Hilo, Hawaii 2011 Phytochemical Society of North America 50th Anniversary Meeting December10-15, 2011 Fairmont Orchid, Hawai’i Table of Contents Meeting Program 7 Invited Speakers 45 Session Abstracts 77 Session 1: PSNA Plenary Session – A Celebration 79 Session 2: The Legacy of Meinhart H. Zenk 81 Session 3: Natural Products in Agriculture 91 Session 4: Chemoprevention 97 Session 5: Biochemistry/Enzymology 109 Session 6: Dietary Supplements 119 Session 7: Botanicals/Medicinals 123 Session 8: New Characterization Methods 131 Session 9: Natural Products Drug Discovery 135 Session 10: Metabolism/Metabolomics 143 Session 11: Phytochemistry/Phytomedicine 153 Session 12: Transcriptomics 157 Session 13: Biofuels and Bioproducts 165 Poster Abstracts 171 Natural Products in Agriculture 173 Chemoprevention 177 Biochemistry/Enzymology 181 Botanicals/Medicinals 189 New Characterization Methods 205 Natural Product Drug Discovery 207 Metabolism/Metabolomics 221 Phytomedicine/Phytochemistry 227 Transcriptome Profiling 243 Biofuels and Bioproducts 245 Author Index 249 2 50TH ANNIVERSARY MEETING Phytochemical Society of North America December 10th – 15th, 2011 The Fairmont Orchid, Hawai’i Welcome and ALOHA PSNA50 Conference Delegates, Accompanying Persons, Sponsors and Exhibitors! We are very pleased to have the 50th anniversary meeting of the Phytochemical Society of North America hosted on the Kohala Coast of the island of Hawaii, the bridge between the west and the east. In true Hawaiian tradition, we welcome each of you (ALOHA and E KOMO MAI). This is a very special time in the society’s history, and we hope that you will enjoy the quite remarkable science, the opportunity to meet with scientific colleagues, as well as the wonderful richness and splendor of Hawaii itself. PSNA 50 represents the culmination of two years intense planning, and brings together a remarkable group and diversity of scientific experts and young scientists alike in each of the main areas of phytochemical research. The program of oral contributions is outstanding, as are the poster sessions. We are very grateful to all of the conference contributors, to our scientific committee and to the local hosts in enabling this wonderful gathering. We also wish to gratefully acknowledge the wonderfully generous support by our various sponsors to whom we give a big MAHALO! (THANK YOU!). Without their support, this meeting would not be possible. The meeting begins with reflections about the Society from Professor Eric Conn, one of the pioneers in PSNA, this being followed by key plenary contributions from HRH Princess Chulabhorn Mahidol (on Thailand’s phytochemical diversity and promise), Mansukh C. Wani (co-discoverer of taxol and camptothecin), Koji Nakanishi (seminal work on ginkgolides), and Daneel Ferreira (on proanthocyanidin/polyphenols). Together, they provide wonderful examples of the importance of our remarkable phytochemical treasures, much of which has only been discovered in the last 50 years. We are saddened with the passing of Professor Meinhart H. Zenk, but honored by the wonderful slate of speakers in sessions dedicated to his quite remarkable scientific legacy. He lives on in very many different ways. The scientific program, thanks to all of you, has wonderful contributions in areas spanning: chemoprevention, natural products drug discovery, medicinal plants, biosynthesis, metabolism/metabolomics, natural products in agriculture, new characterization methods, dietary supplements, phytochemistry/phytomedicine, transcriptomics/metabolomics, as well as the emerging areas of biofuels/bioproducts. There is something for everyone! PSNA 50 also has special sessions dedicated to our young scientists, at the undergraduate, graduate and postdoctoral levels. We would ask each of you to participate in these activities as well, and to provide your support for their endeavors. Welcome to Hawaii. Welcome to PSNA 50. (MAHALO! ALOLHA AND MALAMA PONO!) (THANK YOU, WELCOME AND ‘TAKE CARE’ (BE SAFE) DURING THE CONFERENCE) Norman G. Lewis Cecilia Mcintosh John Pezzuto Conference Chair President Local Host PSNA 50 PSNA 50 PSNA 50 3 Scientific Committee Norman G. Lewis, Chair, Washington State University Ikuro Abe, University of Tokyo Gynheung An, Kyung Hee University Yoshinori Asakawa, Tokushima Bunri University K. Hüsnü Can Baser, Anadolu University Rudolf Bauer, University of Graz Jörg Bohlmann, University of British Columbia G. Paul Bolwell, Royal Holloway, University of London Vanderlan Da Silva Bolzani, Universidade Estadual Paulista, Instituto de Química Wanchai De-Eknamkul, Chulalongkorn University Daneel Ferreira, University of Mississippi Mary Garson, University of Queensland Jonathan Gershenzon, Max Planck Institute for Chemical Ecology De-an Guo, Shanghai Institute of Materia Medica Mahabir P. Gupta, Massuo Jorge Kato, University of São Paulo Ikhlas A. Khan, University of Mississippi Toni M. Kutchan, Donald Danforth Plant Science Center Rachel Mata, Universidad Nacional Autónoma de Mexico Susan McCormick, United States Dept. of Agriculture Cecilia A. McIntosh, East Tennessee State University Birger Lindberg Møller, University of Copenhagen W. David Nes, Texas Tech University Hermann M. Niemeyer, Universidad de Chile M. Soledade C. Pedras, University of Saskatchewan John M. Pezzuto, University of Hawaii at Hilo Richard Robins, Université de Nantes Michel Rohmer, Université de Strasbourg Rosario Rojas, Kazuki Saito, RIKEN and Chiba University, Joachim Stöckigt, Zhejiang University Dieter Strack, Leibniz-Institute of Plant Biochemistry Hermann Stuppner, University of Innsbruck Toshiaki Umezawa, Kyoto University Robert Verpoorte, Leiden University 4 Organizing Committee Norman G. Lewis, Ph.D. John M. Pezzuto, Ph.D. Committee Chair Local Host Director, Institute of Biological Chemistry Professor and Dean College of Pharmacy Washington State University University of Hawai’i at Hilo Charles L. Cantrell, Ph.D. Cecilia A. Mcintosh, Ph.D. PSNA President PSNA President-Elect National Center for Natural Products Research Professor, Biological Sciences USDA-ARS Dean, School of Graduate Studies East Tennessee State University David R. Gang, Ph.D. Mark A. Bernards, Ph.D. PSNA Past-President PSNA Past-President Associate Professor and Fellow Professor & Chair Institute of Biological Chemistry Department of Biology Washington State University The University of Western Ontario John Thor Amason, Ph.D. Laurence B. Davin, Ph.D. Professor of Biology Institute of Biological Chemistry Department of Biology Washington State University University of Ottawa Judith Fox-Goldstein, CFEE Administrative Director University of Hawai’i at Hilo Conference Center 5 Meeting Program SATURDAY 10 DECEMBER 03:00–05:00 pm Executive Committee Meeting Plaza III 02:30–08:30 pm Registration and Information Table Paniolo Hospitality 02:30–06:00 pm Poster Setup Salon III & Ballroom Courtyard 06:00–08:30 pm Welcome Reception Turtle Point 7 SUNDAY 11 DECEMBER 07:30–03:30 Registration and Information Table Grande Ballroom Foyer Opening Remarks: Salon I, II 08:00–08:10 Hawaiian Protocol John M. Pezzuto and Norman G. Lewis 08:10–08:15 Welcome Address: William "Billy" Kenoi, Mayor of Hawaii 08:15–08:35 Eric E. Conn (University of California at Davis) OR1 PSNA: Some reflections Session 1: PSNA Plenary Session – A Celebration Salon I, II Chair: Norman G. Lewis 08:40–09:20 Chulabhorn Mahidol (Chulabhorn Graduate Institute) S1.1 Natural products with biological activities from Thai bioresources 09:20–10:00 Koji Nakanishi (Columbia University) S1.2 Ginkgolides - Structures, reactions and bioactivities 10:00–10:30 Break Ballroom Courtyard & Grande Ballroom Foyer 10:30–11:10 Mansukh C. Wani (RTI International) S1.3 From yew to me to you: A personal history of the discovery and development of plant-derived anticancer agent, taxol 11:10–11:50 Daneel Ferreira (University of Mississippi) S1.4 Half a century of proanthocyanidin/polyphenol research 11:50–12:00 pm Photos 12:00–01:00 Lunch Ballroom Courtyard & Grande Ballroom Foyer 12:00–01:00 Finding a Graduate Program Workshop Plaza Ballroom Chair: Daniel Owens Panelists: Aruna Kilaru, Norman G. Lewis, Cecilia A. McIntosh, and John Romeo 01:00–06:00 Concurrent Session 2: The Legacy of Meinhart H. Zenk S2 Salon I, II Concurrent Session 3: Natural Products in Agriculture S3 Promenade Ballroom Concurrent Session 4: Chemoprevention S4 Plaza Ballroom 07:00–10:00 Poster Session I and Student/Postdoctoral Fellow Competition – Reception Salon III & Ballroom Courtyard 8 SUNDAY 11 DECEMBER Concurrent Session 2: The Legacy of Meinhart H. Zenk Salon, I, II Chair: Nick Amrhein 01:00–01:30 Norman G. Lewis (Washington State University) S2.1 The road from Munich: Meinhart H. Zenk’s legacy 01:30–02:00 Birger Lindberg Møller (University of Copenhagen) S2.2 Functioning dependent metabolons: The "oxime bomb" in cyanogenic glucoside metabolism 02:00–02:30 Fumihiko Sato (Kyoto University) S2.3 The great footprints of the late Prof. Meinhart Zenk in isoquinoline alkaloid biosynthesis studies 02:30–03:00 Kazuki Saito (Chiba University and RIKEN) S2.4 Biosynthetic study of quinolizidine alkaloid – History and recent advancement 03:00–03:30 Joachim Stöckigt (Zhejiang University) S2.5 Alkaloid synthesis beyond the Rauvolfia alkaloidal network 03:30–04:00 Break Ballroom Courtyard & Grande Ballroom Foyer 04:00–04:30 Wanchai De-Eknambul (Chulalongkorn University) S2.6 My research experience with Prof. Meinhart Zenk, the pioneer of benzylisoquinoline alkaloid biosynthesis 04:30–05:00 Vincenzo De Luca (Brock University) S2.7
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