Osmium Tetroxide

Total Page:16

File Type:pdf, Size:1020Kb

Osmium Tetroxide Osmium tetroxide sc-206008 Material Safety Data Sheet Hazard Alert Code EXTREME HIGH MODERATE LOW Key: Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME Osmium tetroxide STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. NFPA FLAMMABILITY0 HEALTH4 HAZARD INSTABILITY2 SUPPLIER Santa Cruz Biotechnology, Inc. 2145 Delaware Avenue Santa Cruz, California 95060 800.457.3801 or 831.457.3800 EMERGENCY ChemWatch Within the US & Canada: 877-715-9305 Outside the US & Canada: +800 2436 2255 (1-800-CHEMCALL) or call +613 9573 3112 SYNONYMS OsO4, "osmic acid anhydride", "osmium oxide", "perosmic oxide", "osmium tetraoxide" Section 2 - HAZARDS IDENTIFICATION CHEMWATCH HAZARD RATINGS Min Max Flammability 0 Toxicity 4 Body Contact 4 Min/Nil=0 Low=1 Reactivity 2 Moderate=2 High=3 Chronic 2 Extreme=4 CANADIAN WHMIS SYMBOLS 1 of 13 EMERGENCY OVERVIEW RISK Contact with combustible material may cause fire. Causes burns. Risk of serious damage to eyes. Very toxic by inhalation, in contact with skin and if swallowed. POTENTIAL HEALTH EFFECTS ACUTE HEALTH EFFECTS SWALLOWED ! Severely toxic effects may result from the accidental ingestion of the material; animal experiments indicate that ingestion of less than 5 gram may be fatal or may produce serious damage to the health of the individual. ! The material can produce chemical burns within the oral cavity and gastrointestinal tract following ingestion. EYE ! The material can produce chemical burns to the eye following direct contact. Vapors or mists may be extremely irritating. ! If applied to the eyes, this material causes severe eye damage. ! Brief exposures to osmium tetroxide vapor produces delayed lachrymation, "halo" effects (appearance of rings around lights) and vision disturbances (gritty feeling in the eyes). These symptoms usually cease a few days after exposure. Exposure to concentrations not high enough to cause immediate irritation can, if prolonged, accumulate to cause the above symptoms. Eye exposure to high concentrations of vapor could cause severe damage or blindness Application of a drop of 1% solution to rabbit's eye caused severe corneal damage, permanent opacity, and superficial vascularisation. SKIN ! Skin contact with the material may produce severely toxic effects; systemic effects may result following absorption and these may be fatal. ! The material can produce chemical burns following direct contactwith the skin. ! Open cuts, abraded or irritated skin should not be exposed to this material. ! Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. ! Skin contact with low concentrations of osmium tetroxide vapor can cause irritation, while contact with high concentrations of vapor or with the solid form can cause severe inflammation, burns, and green or black discoloration. Kidney or liver damage may also result. INHALED ! If inhaled, this material can irritate the throat andlungs of some persons. ! Inhalation of vapors, aerosols (mists, fumes) or dusts, generated by the material during the course of normal handling, may produce severely toxic effects; these may be fatal. ! Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled. If prior damage to the circulatory or nervous systems has occurred or if kidney damage has been sustained, proper screenings should be conducted on individuals who may be exposed to further risk if handling and use of the material result in excessive exposures. ! Inhalation of osmium tetroxide vapor may irritate the nose, throat, and bronchial tubes, causing a cough, wheezing, pneumonia, and headache The vapor produces acute tracheobronchitis characterized by cough, sore throat, chest pain and lightheadedness The lungs and respiratory tract retain most of the inhaled osmium tetroxide vapors causing irritation and black discolouration . Lung, liver, or kidney damage could result from inhalation exposure. It is likely that, upon contact with the pulmonary mucosa, most inhaled osmium tetroxide is reduced to the metal, causing tissue damage. It does this without penetrating the alveolar barrier or entering the bloodstream Osmium tetroxide should only be handled in a ventilated fume hood. Inhalation may cause headache, coughing, dizziness, difficult breathing and may be fatal. Workers have described exposure to osmium tetroxide as "having the kick of a mule". Nose and throat irritation may persist at least 12 hours after exposure has ceased. Some employees complain of headache, conjunctivitis and cough. Symptoms sometimes developed after inhaling osmium tetroxide for 2 hours and, in most cases, did not resolve for a few days. An early osmium fatality (1874) showed capillary bronchitis and frank pulmonary oedema autopsy. CHRONIC HEALTH EFFECTS ! Repeated or prolonged exposure to corrosives may result in the erosion of teeth, inflammatory and ulcerative changes in the mouth and necrosis (rarely) of the jaw. Bronchial irritation, with cough, and frequent attacks of bronchial pneumonia may ensue. Gastrointestinal disturbances may also occur. Chronic exposures may result in dermatitis and/or conjunctivitis. Substance accumulation, in the human body, may occur and may cause some concern following repeated or long-term occupational exposure. Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Prime symptom is breathlessness; lung shadows show on X-ray. Chronic exposure to trace amounts of osmium tetroxide may result in kidney and liver damage. Currently, there is no evidence that osmium tetroxide is carcinogenic. However, it has been shown to induce DNA lesions and DNA-repair replication in mammalian cells 2 of 13 Osmium tetroxide has shown reproductive toxicity in animals; however, it has not shown reproductive or developmental effects in humans. The long-term use of osmium tetroxide for the treatment of rheumatoid arthritis may produce chronic toxic effects following intraarticular injection. This may occur as a result of accumulation in liver, heart, spleen and kidney. Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS NAME CAS RN % osmium tetroxide 20816-12-0 >99 Section 4 - FIRST AID MEASURES SWALLOWED For advice, contact a Poisons Information Centre or a doctor at once. Urgent hospital treatment is likely to be needed. If swallowed do NOT induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain open airway and prevent aspiration. Observe the patient carefully. Never give liquid to a person showing signs of being sleepy or with reduced awareness; i.e. becoming unconscious. Give water to rinse out mouth, then provide liquid slowly and as much as casualty can comfortably drink. Transport to hospital or doctor without delay. EYE If this product comes in contact with the eyes Immediately hold eyelids apart and flush the eye continuously with running water. Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and moving the eyelids by occasionally lifting the upper and lower lids. Continue flushing until advised to stop by the Poisons Information Centre or a doctor, or for at least 15 minutes. Transport to hospital or doctor without delay. Removal of contact lenses after an eye injury should only be undertaken by skilled personnel. SKIN If skin or hair contact occurs Immediately flush body and clothes with large amounts of water, using safety shower if available. Quickly remove all contaminated clothing, including footwear. Wash skin and hair with running water. Continue flushing with water until advised to stop by the Poisons Information Centre. Transport to hospital, or doctor. INHALED If fumes or combustion products are inhaled remove from contaminated area. Lay patient down. Keep warm and rested. Prostheses such as false teeth, which may block airway, should be removed, where possible, prior to initiating first aid procedures. Apply artificial respiration if not breathing, preferably with a demand valve resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if necessary. Transport to hospital, or doctor, without delay. NOTES TO PHYSICIAN ! Treat symptomatically. for poisons (where specific treatment regime is absent) -------------------------------------------------------------- BASIC TREATMENT -------------------------------------------------------------- Establish a patent airway with suction where necessary. Watch for signs of respiratory insufficiency and assist ventilation as necessary. Administer oxygen by non-rebreather mask at 10 to 15 L/min. Monitor and treat, where necessary, for pulmonary oedema . Monitor and treat, where necessary, for shock. Anticipate seizures . DO NOT use emetics. Where ingestion is suspected rinse mouth and give up to 200 ml water (5 ml/kg recommended) for dilution where patient is able to swallow, has a strong gag reflex and does not drool. -------------------------------------------------------------- ADVANCED TREATMENT -------------------------------------------------------------- Consider orotracheal or nasotracheal intubation for airway control in unconscious patient or where respiratory
Recommended publications
  • United States Patent (19) 11 Patent Number: 4,496,778 Myers Et Al
    United States Patent (19) 11 Patent Number: 4,496,778 Myers et al. (45) Date of Patent: Jan. 29, 1985 (54) PROCESS FOR THE HYDROXYLATION OF 56 References Cited OLEFINS USING MOLECULAR OXYGEN, U.S. PATENT DOCUMENTS ANOSMIUM CONTAINING CATALYST, A COPPER CO-CATALYST, AND AN 2,773, 101 12/1956 Smith et al. ......................... 568/860 AROMATIC AMINE BASED PROMOTER 3,317,592 5/1967 Maclean et al. ... 568/860 3,337,635 8/1967 Norton et al. ....... 568/860 75 Inventors: Richard S. Myers, Fairlawn; Robert 4,390,739 6/1983 Michaelson et al. .... ..., 568/860 C. Michaelson, Waldwick; Richard FOREIGN PATENT DOCUMENTS G. Austin, Ridgewood, all of N.J. 32522 8/1974 Japan ................................... 568/860 73) Assignee: Exxon Research & Engineering Co., Primary Examiner-J. E. Evans Florham Park, N.J. Attorney, Agent, or Firm-Robert A. Maggio 21 Appl. No.: 538,190 57 ABSTRACT A process directed to the hydroxylation of olefins by 22 Filed: Oct. 3, 1983 reacting said olefins in the presence of oxygen, water, and a catalyst composition comprising (i) a catalytically 51 Int. Cl. ...................... C07C 29/04; CO7C 31/18; active osmium containing compound, (ii) a Co-catalyst C07C 31/22; CO7C 31/42 I comprising a copper containing compound such as 52 U.S.C. ................................. 568/860; 260/.397.2; CuBr2, and (iii) a Co-catalyst II capable of increasing 560/186; 562/587; 568/811; 568/821; 568/833; the rate and/or selectivity of the hydroxylation reac 568/838; 568/847 tion, such as pyridine is disclosed. 58 Field of Search ..............
    [Show full text]
  • Cellular Uptake and Toxicological Effects of Differently Sized Zinc Oxide Nanoparticles in Intestinal Cells †
    toxics Article Cellular Uptake and Toxicological Effects of Differently Sized Zinc Oxide Nanoparticles in Intestinal Cells † Anna Mittag 1,* , Christian Hoera 2, Alexander Kämpfe 2 , Martin Westermann 3, Jochen Kuckelkorn 4, Thomas Schneider 1 and Michael Glei 1 1 Department of Nutritional Toxicology, Institute of Nutritional Sciences, Friedrich Schiller University Jena, Dornburger Straße 24, 07743 Jena, Germany; [email protected] (T.S.); [email protected] (M.G.) 2 German Environment Agency, Swimming Pool Water, Chemical Analytics, Heinrich-Heine-Straße 12, 08645 Bad Elster, Germany; [email protected] (C.H.); [email protected] (A.K.) 3 Electron Microscopy Centre, Friedrich Schiller University Jena, Ziegelmühlenweg 1, 07743 Jena, Germany; [email protected] 4 German Environment Agency, Toxicology of Drinking Water and Swimming Pool Water, Heinrich-Heine-Straße 12, 08645 Bad Elster, Germany; [email protected] * Correspondence: [email protected] † In respectful memory of Dr. Tamara Grummt. Abstract: Due to their beneficial properties, the use of zinc oxide nanoparticles (ZnO NP) is constantly increasing, especially in consumer-related areas, such as food packaging and food additives, which is leading to an increased oral uptake of ZnO NP. Consequently, the aim of our study was to investigate the cellular uptake of two differently sized ZnO NP (<50 nm and <100 nm; 12–1229 µmol/L) using two human intestinal cell lines (Caco-2 and LT97) and to examine the possible resulting toxic effects. ZnO NP (<50 nm and <100 nm) were internalized by both cell lines and led to intracellular changes. Citation: Mittag, A.; Hoera, C.; Kämpfe, A.; Westermann, M.; Both ZnO NP caused time- and dose-dependent cytotoxic effects, especially at concentrations of Kuckelkorn, J.; Schneider, T.; Glei, M.
    [Show full text]
  • The Two Faces of Titanium Dioxide Nanoparticles Bio-Camouflage in 3D
    www.nature.com/scientificreports OPEN The two faces of titanium dioxide nanoparticles bio-camoufage in 3D bone spheroids Received: 23 October 2018 W. Souza1,2,3, S. G. Piperni3,4, P. Laviola1,3,5, A. L. Rossi4, Maria Isabel D. Rossi6, Accepted: 11 June 2019 Bráulio S. Archanjo7, P. E. Leite 1,2,8, M. H. Fernandes9,12, L. A. Rocha3,10, J. M. Granjeiro1,2,3,11 Published: xx xx xxxx & A. R. Ribeiro 2,3,5 Titanium (Ti) and its alloys are widely used in dental implants and hip-prostheses due to their excellent biocompatibility. Growing evidence support that surface degradation due to corrosion and wear processes, contribute to implant failure, since the release of metallic ions and wear particles generate local tissue reactions (peri-implant infammatory reactions). The generated ions and wear debris (particles at the micron and nanoscale) stay, in a frst moment, at the interface implant-bone. However, depending on their size, they can enter blood circulation possibly contributing to systemic reactions and toxicities. Most of the nanotoxicological studies with titanium dioxide nanoparticles (TiO2 NPs) use conventional two-dimensional cell culture monolayers to explore macrophage and monocyte activation, where limited information regarding bone cells is available. Recently three- dimensional models have been gaining prominence since they present a greater anatomical and physiological relevance. Taking this into consideration, in this work we developed a human osteoblast- like spheroid model, which closely mimics bone cell-cell interactions, providing a more realistic scenario for nanotoxicological studies. The treatment of spheroids with diferent concentrations of TiO2 NPs during 72 h did not change their viability signifcantly.
    [Show full text]
  • United States Patent Office Attented Oct
    3,536,479 United States Patent Office attented Oct. 27, 1970 2 a hydrogen pressure of at least about 15 pounds per 3,536,479 square inch gauge (p.S.i.g.). METHOD FOR THE PRODUCTION OF HIGH PURTY (OSMUM The concentrated osmium-containing solution can ad Alexander Ellis, Clarkson, Ontario, and Alan Manson, vantageously be prepared from a dilute osmium-contain Oakville, Ontario, Canada, assignors to The Interna 5 ing solution as described hereinafter. However, most gen tional Nicke Company, Inc., New York, N.Y., a cor erally the concentrated solution will be prepared by poration of Delaware scrubbing gases containing osmium tetroxide with a Solu No Drawing. Filled Dec. 13, 1967, Ser. No. 690,083 tion containing, by weight, about 5% to 40% sodium hy Claims priority, application Canada, Feb. 21, 1967, droxide to produce a sodium perosmate solution which 983,421 10 contains about 5 grams per liter (gp.l.) to about 100 nt. C. C22b 7/00, 11/04 g.p.l. of osmium, e.g., about 60 g.p.l. of osmium. Gen U.S. C. 75-108 29 Claims erally at this stage only minor amounts of ruthenium, i.e., less than about 0.5 g.p.l. of ruthenium, accompany the osmium and can be precipitated with only minor ABSTRACT OF THE DISCLOSURE 5 amounts of osmium occluded therein from the concen Metallic osmium is recovered from a slurry of an trated osmium-containing solution by adding a Water osmium-containing material to which sufficient hydro soluble, mild organic reducing agent such as methyl al chloric acid has been added to assure a final pH value cohol and ethyl alcohol.
    [Show full text]
  • Deposition of Osmium Tetroxide on Reactive Surfaces
    Deposition of osmium tetroxide on reactive surfaces A. von Zweidorf1,2, R. Angert1, W. Brüchle1, E. Jäger1, J.V. Kratz2, G. Langrock2, M. Mendel2, A. Nähler2, M. Schädel1, B. Schausten1, E. Schimpf1, E. Stiel1, N. Trautmann2, G. Wirth1 1Gesellschaft für Schwerionenforschung, Darmstadt, 2Institut für Kernchemie, Johannes Gutenberg-Universität Mainz The recent study of the chemistry of element 108, hassium [1], cis-1,4-polybutadiene is more reactive than etched surfaces of leads to the conclusion, that it forms a volatile oxide, as zinc and lead, on which almost nothing is deposited. expected for a member of group 8 of the periodic table [2]. So This leads to the implication, that alternative materials for the far, no chemical reaction of this oxide is known. To learn more deposition of OsO4 are needed. about the chemical behaviour of hassium, one would like to If alkaline materials are suitable for our purposes, an alkaline investigate the chemistry of hassium oxide, the only known surface would be most efficient. Unfortunately, it is hardly compound of hassium. Presumably, it is chemically similar to possible to reproducibly prepare thin layers of an alkali OsO4 and RuO4, which have an acidic character and are able to hydroxide without a substrate. Nevertheless, is it possible to form salts with alkaline materials. coat an inert material with a smooth layer of alkali hydroxide. For that reason, a Continuously Working Arrangement For We choosed at first graphite as inert substrate and coated it with Clusterless Transport Of In-situ Produced Volatile Oxides, a thin layer of KOH, using the solubility of KOH in C2H5OH CALLISTO, was developed and successfully used to deposit the and preparing the layer from an ethanolic solution.
    [Show full text]
  • Particularly Hazardous Substances
    Particularly Hazardous Substances In its Laboratory Standard, OSHA requires the establishment of additional protections for persons working with "Particularly Hazardous Substances" (PHS). OSHA defines these materials as "select" carcinogens, reproductive toxins and acutely toxic materials. Should you wish to add: explosive, violently reactive, pyrophoric and water-reactve materials to this category, the information is included. Carbon nanotubes have also been added due to their suspected carcinogenic properties. This table is designed to assist the laboratory in the identification of PHS, although it is not definitively conclusive or entirely comprehensive. *Notes on the proper use of this table appear on page 12. 1 6 5 2 3 4 Substance CAS National Toxicity National Program Carcinogen Toxin Acute Regulated OSHA Carcinogen Group IARC Carcinogen Toxin Reproductive Violently Reactive/ Explosive/Peroxide Forming/Pyrophoric A-a-C(2-Amino-9H-pyrido[2,3,b]indole) 2648-68-5 2B Acetal 105-57-7 yes Acetaldehyde 75-07-0 NTP AT 2B Acrolein (2-Propenal) 107-02-8 AT Acetamide 126850-14-4 2B 2-Acetylaminofluorene 53-96-3 NTP ORC Acrylamide 79-06-6 NTP 2B Acrylyl Chloride 814-68-6 AT Acrylonitrile 107-13-1 NTP ORC 2B Adriamycin 23214-92-8 NTP 2A Aflatoxins 1402-68-2 NTP 1 Allylamine 107-11-9 AT Alkylaluminums varies AT Allyl Chloride 107-05-1 AT ortho-Aminoazotoluene 97-56-3 NTP 2B para-aminoazobenzene 60-09-3 2B 4-Aminobiphenyl 92-67-1 NTP ORC 1 1-Amino-2-Methylanthraquinone 82-28-0 NTP (2-Amino-6-methyldipyrido[1,2-a:3’,2’-d]imidazole) 67730-11-4 2B
    [Show full text]
  • Toxic Manifestations of Osmium Tetroxide
    Br J Ind Med: first published as 10.1136/oem.3.3.183 on 1 July 1946. Downloaded from TOXIC MANIFESTATIONS OF OSMIUM TETROXIDE BY A. I. G. McLAUGHLIN, R. MILTON and KENNETH M. A. PERRY From the University of Sheffield and Factory Department, Ministry of Labour and National Service, and the Department for Research in Industrial Medicine (Medical Research Council), the London Hospital Osmium is one of the precious metals and was the vapours of osmic acid gave rise to a capillary discovered in 1803 by Tenant. It occurs naturally bronchitis from which he died. Necropsy revealed in close association with iridium. Osmiridium is a confluent broncho-pneumonia with a tendency to an exceptionally hard alloy with a high melting- suppuration and gangrene; there was also a fatty point (2700° C.) and for this reason it is used degeneration of the epithelium of the renal tubules. extensively for tipping fountain-pen nibs. It is Bardieux (1898) showed that the subcutaneous and also used for electrical contacts, as a catalyst in the intramuscular injection of a 1 per cent. solution of preparation of synthetic ammonia, and for measur- osmic acid produced no serious effect in animals ing the rapidity of explosion of gun-cotton. Before but that small quantities injected into the lungs the introduction of tungsten, electric lamp filaments were immediately fatal. Attempts have been made were sometimes made with it. Osmium is also to make use of the solution in treating diseases such used in the taking of finger-prints, and osmic acid as tuberculosis (Walbum, 1926), syphilis (Levaditi, which is a watery solution of osmium tetroxide is 1927; and Jahnel, 1937) and cancer (Kraus, 1931) used for activating solutions of chlorate of potas- but without success, though Fischl (1933) showed it sium; hardening and colouring certain prepara- possessed some spirochaetocidal properties in tions and in histology for the fixing and staining of experimentally infected mice Coca (1908) studied nerves and fat.
    [Show full text]
  • Ruthenium Tetroxide and Perruthenate Chemistry. Recent Advances and Related Transformations Mediated by Other Transition Metal Oxo-Species
    Molecules 2014, 19, 6534-6582; doi:10.3390/molecules19056534 OPEN ACCESS molecules ISSN 1420-3049 www.mdpi.com/journal/molecules Review Ruthenium Tetroxide and Perruthenate Chemistry. Recent Advances and Related Transformations Mediated by Other Transition Metal Oxo-species Vincenzo Piccialli Dipartimento di Scienze Chimiche, Università degli Studi di Napoli ―Federico II‖, Via Cintia 4, 80126, Napoli, Italy; E-Mail: [email protected]; Tel.: +39-081-674111; Fax: +39-081-674393 Received: 24 February 2014; in revised form: 14 May 2014 / Accepted: 16 May 2014 / Published: 21 May 2014 Abstract: In the last years ruthenium tetroxide is increasingly being used in organic synthesis. Thanks to the fine tuning of the reaction conditions, including pH control of the medium and the use of a wider range of co-oxidants, this species has proven to be a reagent able to catalyse useful synthetic transformations which are either a valuable alternative to established methods or even, in some cases, the method of choice. Protocols for oxidation of hydrocarbons, oxidative cleavage of C–C double bonds, even stopping the process at the aldehyde stage, oxidative cleavage of terminal and internal alkynes, oxidation of alcohols to carboxylic acids, dihydroxylation of alkenes, oxidative degradation of phenyl and other heteroaromatic nuclei, oxidative cyclization of dienes, have now reached a good level of improvement and are more and more included into complex synthetic sequences. The perruthenate ion is a ruthenium (VII) oxo-species. Since its introduction in the mid-eighties, tetrapropylammonium perruthenate (TPAP) has reached a great popularity among organic chemists and it is mostly employed in catalytic amounts in conjunction with N-methylmorpholine N-oxide (NMO) for the mild oxidation of primary and secondary alcohols to carbonyl compounds.
    [Show full text]
  • Material Safety Data Sheet Product No. 18466 Osmium Tetroxide, 2% Aqueous Issue Date (06-05-12) Review Date (06-05-12)
    Material Safety Data Sheet Product No. 18466 Osmium Tetroxide, 2% Aqueous Issue Date (06-05-12) Review Date (06-05-12) Section 1: Product and Company Identification Product Name: Osmium Tetroxide, 2% Aqueous Synonym: Osmium Tetroxide, Osmic Acid Solution, Osmium (VIII) Oxide Chemical Family: Platinum Group Metal Salts Company Name Ted Pella, Inc. P.O. Box 492477, Redding, CA 96049-2477 Domestic Phone (800) 237-3526 (Mon-Thu. 6:00AM to 4:30PM PST; Fri 6:00AM to 4:00PM PST) International Phone (01) (530) 243-2200 (Mon-Thu. 6:00AM to 4:30PM PST; Fri 6:00AM to 4:00PM PST) Chemtrec Emergency Number 1-800-424-9300 24 hrs a day. Section 2: Composition / Information on Ingredients % Principle Hazardous OSHA ACGIH ACGIH OSHA Component(s) PEL TLV TLV- NTP IARC (chemical and common name(s)) regulated (Cas. No) mg/m3 mg/m3 STEL ppm Osmium Tetroxide/Osmium 2 0.002 0.0006 0.002 No No No Oxide (20816-12-0) Water (7732-18-5) 98 NE NE NE No No No Section 3: Hazard Identification Emergency overview Appearance: Colorless to pale yellow solution. Immediate effects: This substance can be absorbed into the body by inhalation of its vapors, by inhalation of its aerosol and by ingestion. May cause sensitization by inhalation and skin contact. Target Organs: Eyes and Central Nervous System. Potential health effects Primary Routes of entry: Eyes: Likely; Inhalation: Highly; Skin: Likely; Ingestion: Likely Signs and Symptoms of Overexposure: ND Eyes: Irritation, lacrimation, visual disturbance, conjunctivitis, headache, potential damage to cornea. If eyes are exposed to vapor over a short period of time, night vision will be affected for about one evening.
    [Show full text]
  • Osmium Tetroxide [CAS No
    LABORATORY SAFETY GUIDELINE Osmium Tetroxide [CAS No. 20816-12-0] All users of Osmium Tetroxide must review this document before use. Osmium tetroxide (OsO4) is a highly poisonous, pale yellow solid that is volatile. It is a corrosive oxidizer that produces an acrid chlorine like odor. Osmium tetroxide is most commonly used in oxidation reactions and as a fixative for biological staining. Users should contact their EHS Laboratory Safety Advisor and department safety officer if they have questions before beginning work. HAZARDS The acute toxicity is high, and it is a severe irritant of the eyes and respiratory tract. Vapors can damage the cornea of the eye and even lead to blindness. Concentrations of vapor that do not cause immediate irritation can have a dangerous cumulative effect; symptoms may not be noted until several hours after exposure. Inhalation can cause chemical burns to the respiratory tract, headache, coughing, dizziness, lung damage, and difficult breathing, and may potentially be fatal. Chronic exposure can result in accumulation of osmium compounds in the liver and kidney, and damage to these organs. Exposure via inhalation, skin contact, or ingestion can lead to systemic toxic effects involving liver and kidney damage. Repeated exposure may cause sensitization by inhalation or skin contact. Corrosive to skin and eyes, exposure may cause blindness. Contact of the vapor with skin can cause dermatitis, and direct contact with the solid can lead to severe irritation and burns. PRECAUTIONS • Osmium tetroxide is a strong oxidizer that will sublime (pass directly from solid to vapor and back to solid) readily at room temperature and significantly when refrigerated.
    [Show full text]
  • Safety Data Sheet Product No. 18466, Osmium Tetroxide, 2% Aqueous Issue Date (06-15-15) Review Date (08-31-17)
    Safety Data Sheet Product No. 18466, Osmium Tetroxide, 2% aqueous Issue Date (06-15-15) Review Date (08-31-17) Section 1: Product and Company Identification Product Name: Osmium Tetroxide, 2% aqueous Synonym: Osmic Acid Solution, Osmium (VIII) Oxide Company Name Ted Pella, Inc., P.O. Box 492477, Redding, CA 96049-2477 Inside USA and Canada 1-800-237-3526 (Mon-Thu. 6:00AM to 4:30PM PST; Fri 6:00AM to 4:00PM PST) Outside USA and Canada 1-530-243-2200 (Mon-Thu. 6:00AM to 4:30PM PST; Fri 6:00AM to 4:00PM PST) CHEMTREC USA and Canada Emergency Contact Number 1-800-424-9300 24 hours a day CHEMTREC Outside USA and Canada Emergency Contact Number +1-703-741-5970 24 hours a day Section 2: Hazard Identification 2.1 Classification of the substance or mixture GHS Pictograms GHS05 GHS06 GHS07 GHS Categories GHS05 – Corrosive GHS06 – Toxic Acute tox, oral (5) H303: May be harmful if swallowed Acute tox, inhalation (3) H331: Toxic if inhaled Specific target organ tox (2) H370: Causes damage to organs Reproductive tox (2) H361: Suspected of damaging fertility or the unborn child. GHS07 – Irritant Serious eye damage/irritation (1) H318: Causes serious eye damage Skin irritation (2) H315: Causes skin irritation 2.2 Label elements Hazard pictograms GHS06 GHS05 GHS07 Signal Word: DANGER Hazard statements H303: May be harmful if swallowed H315: Causes skin irritation H318: Causes serious eye damage H331: Toxic if inhaled H370: Causes damage to organs H361: Suspected of damaging fertility or the unborn child Precautionary statements P202: Do not handle until all safety precautions have been read and understood P210: Keep away from heat/sparks/open flames/hot surfaces – No smoking P264: Wash thoroughly after handling P280: Wear protective gloves/protective clothing/eye protection/face protection P308+313: IF exposed or concerned: Get medical advice/attention.
    [Show full text]
  • The Preparation and Characterization of Some Alkanethiolatoosmium Compounds Harold Harris Schobert Iowa State University
    Iowa State University Capstones, Theses and Retrospective Theses and Dissertations Dissertations 1970 The preparation and characterization of some alkanethiolatoosmium compounds Harold Harris Schobert Iowa State University Follow this and additional works at: https://lib.dr.iastate.edu/rtd Part of the Inorganic Chemistry Commons Recommended Citation Schobert, Harold Harris, "The preparation and characterization of some alkanethiolatoosmium compounds " (1970). Retrospective Theses and Dissertations. 4357. https://lib.dr.iastate.edu/rtd/4357 This Dissertation is brought to you for free and open access by the Iowa State University Capstones, Theses and Dissertations at Iowa State University Digital Repository. It has been accepted for inclusion in Retrospective Theses and Dissertations by an authorized administrator of Iowa State University Digital Repository. For more information, please contact [email protected]. 71-14,258 SCHOBERT, Harold Harris, 1943- THE PREPARATION AND CHARACTERIZATION OF SOME ALKANETHIOLATOOSMIUM COMPOUNDS. Iowa State University, Ph.D., 1970 Chemistry, inorganic University Microfilms, A XEROX Company, Ann Arbor, Michigan THIS DISSERTATION HAS BEEH MICROFILMED EXACTLY AS RECEIVED THE PREPARATION AND CHARACTERIZATION OF SOME ALKANETHIOLATOOSMIUM COMPOUNDS by Harold Harris Schobert A Dissertation Submitted to the Graduate Faculty in Partial Fulfillment of The Requirements for the Degree of DOCTOR OF PHILOSOPHY Major Subject: Inorganic Chemistry Approved: Signature was redacted for privacy. Signature was redacted for
    [Show full text]