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A New Biological Definition of Life BioMol Concepts 2020; 11: 1–6 Research Article Open Access Victor V. Tetz, George V. Tetz* A new biological definition of life https://doi.org/10.1515/bmc-2020-0001 received August 17, 2019; accepted November 22, 2019. new avenues for drug development and prediction of the results of genetic interventions. Abstract: Here we have proposed a new biological Defining life is important to understand the definition of life based on the function and reproduction development and maintenance of living organisms of existing genes and creation of new ones, which is and to answer questions on the origin of life. Several applicable to both unicellular and multicellular organisms. definitions of the term “life” have been proposed (1-14). First, we coined a new term “genetic information Although many of them are highly controversial, they are metabolism” comprising functioning, reproduction, and predominantly based on important biological properties creation of genes and their distribution among living and of living organisms such as reproduction, metabolism, non-living carriers of genetic information. Encompassing growth, adaptation, stimulus responsiveness, genetic this concept, life is defined as organized matter that information inheritance, evolution, and Darwinian provides genetic information metabolism. Additionally, approach (1-5, 15). we have articulated the general biological function of As suggested by the Nobel Prize-winning physicist, life as Tetz biological law: “General biological function Erwin Schrödinger, in his influential essay What Is of life is to provide genetic information metabolism” and Life ?, the purpose of life relies on creating an entropy, formulated novel definition of life: “Life is an organized and therefore defined living things as not just a “self- matter that provides genetic information metabolism”. reproducing” entity as living cells involve more than just New definition of life and Tetz biological law allow to replication of DNA (10). Some authors have proposed distinguish in a new way living and non-living objects the definition of life predominantly based on the fact on Earth and other planets based on providing genetic of reproduction, such as “Life is metabolizing material information metabolism. informational system with ability of self-reproduction with variations” proposed by Trifonov (14). This definition Keywords: definition of life, biological theory; The is close but is a much more minimalistic determination General biological law; Pangenome; modified genes. of life compared with the definition of Macklem and Seely - selfcontained, self-regulating, self-organizing, selfreproducing, interconnected, open thermodynamic Article network of component parts which performs work, existing in a complex regime which combines stability In the last few decades, there has intensive development and adaptability in the phase transition between order in molecular biology and its pervasion into various fields and chaos, as a plant, animal, fungus, or microbe” (3). of biology and medicine. In this milieu, it is important to On the contrary, all definitions based on reproduction have a biological law that can unify the functions of all are limited to events that happen on the Earth, but they living unicellular and multicellular organisms, as well as should be applicable to other possible forms of life in the non-living carriers of genetic information, into a single universe (3). system of biological definition of life. The formulation of Combining various characteristics of living objects, such a law based on the definitions of life and the general Ruiz-Mirazo et al. defined living entities as “autonomous biological functions of life will allow the identification of systems with open-ended evolution capacities, and that all such systems must have a semi-permeable active boundary (membrane), an energy transduction apparatus *Corresponding author: George V. Tetz, Human Microbiology (set of energy currencies) and, at least, two types of Institute, 101 Avenue of Americas, New York, NY 10013, functionally interdependent macromolecular components E-mail: [email protected] (catalysts and records)” (13). Victor V. Tetz, Human Microbiology Institute, 101 Avenue of Americas, New York, NY 10013 Open Access. © 2019 Victor V. Tetz, George V. Tetz, published by De Gruyter. This work is licensed under the Creative Commons Attribution-NonCommercial NoDerivatives 4.0 License. 2 Victor V. Tetz, George V. Tetz: A new biological definition of life Furthermore, for over 200 years, the most influential have collectively termed all of these non-living objects as biologists have discussed the definition and origin of life “non-living genetic elements” (NLGEs). without precise definitions, with only phenomenological The definition of viruses as non-living entities is descriptions and explanations (16). consistent with that of many authors; however, their The problems and inaccuracies with the existing definitions are based on other characteristics such as definitions of “life” arise due to the appearance of new lack of cell metabolism and the fact that viruses do not categories such as artificial life (a-life, synthetic life) and reproduce by themselves (28). As viruses evolve, certain life engineered by redesigning of biological components characteristic of living organisms, as suggested by some that is studied in the field of synthetic biology (17-19). authors, can be transferred into viruses, making them Furthermore, the definition of life must be universal, for living organisms, considering that all biological entities both unicellular and multicellular organisms (1, 20). The that actively participate in the process of life are living (29, current definitions of life correspond to the phenomenon 30). of life; but in our opinion, they do not reflect the connection According to our definition of life, viruses are of the three-domain system of Archaea, Bacteria, and considered non-living as they do not provide “genetic Eukarya proposed by Woese in the united network of the information metabolism”, which distinguishes them from essence of life and do not reflect interactions with non- living objects. living objects (21). Living organisms depend on NLGEs for the Here, we propose a new definition of life, “Life is distribution and spreading of their genetic information an organized matter that provides genetic information during horizontal gene transfer (HGT; also known as metabolism”. We defined “genetic information lateral gene transfer) (31, 32). One of the most common metabolism” as the process responsible for, and involved mechanisms of acquiring antibiotic resistance is due to in, DNA and RNA replication, methylation, repair, HGT implemented with plasmids, bacteriophages, cell- mutation, transcription, recombination, survival, and free DNA, and other NLGEs (33, 34). Recent studies have their spreading in both unicellular and multicellular also demonstrated gene transfer between phylogenetically organisms. Based on the above, we have articulated the distinct organisms, such as between eukaryotic cells and general biological functions of life as the Tetz biological bacteria, and vice versa (35-37). It has been demonstrated law “General biological function of life is to provide that bacteria have even acquired genetic material from the genetic information metabolism”. human genome (38). Moreover, some bacteriophages have We also describe the general biological functions of been found to harbor eukaryotic genes (39). The primary life as the Tetz biological law based on the Pangenome goal of NLGEs in the maintenance of living organisms is concept (22, 23). The Pangenome concept is the collective highlighted by their global distribution. The total number genetic system of all living organisms and comprises of NLGEs in the environment exceeds the number of the organic molecules and their complexes (DNA- and unicellular and multicellular organisms by many times. RNA-containing viruses, plasmids, transposons, and Indeed, it is estimated that there are >1031 phage particles in insertion sequences) that are involved in the storage the ocean, the adult human contains >1015 bacteriophages, and transmission of genetic information (24-27). The and marine sediments are believed to contain >0.45 Pangenome concept has been proposed as a common gigatons of cell-free DNA and extracellular DNA (eDNA) platform uniting both living and non-living parts of (40, 41). eDNA and eRNA are released and are present in nature, and it focuses on the properties of all objects most terrestrial and aquatic environments, in bacterial carrying genetic information. The Pangenome is and fungal biofilms, and in animal and human blood, hypothesized to respond to environmental changes as where they play an important role in the distribution of a whole, independently from any individual species, genes and are frequently acquired by other organisms through the development, maintenance, and distribution (42, 43-46). We believe that generation and propagation of modified genes for use by multiple organisms, of modified genes occur in the cells of living carriers, including unrelated ones. Building on the Pangenome while their distribution among the microbiome involves concept, we divided all the carriers of genetic information the active participation of NLGEs. Indeed, the formation included in the Pangenome into the categories of “living” of new genes is possible only in living organisms as a and “non-living”. Living carriers include all unicellular result of various changes
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