A Comprehensive Review of Overactive Bladder Pathophysiology: on the Way to Tailored Treatment
EUROPEAN UROLOGY 75 (2019) 988– 1000 available at www.sciencedirect.com journal homepage: www.europeanurology.com Review – Female Urology – Incontinence – Editor’s Choice A Comprehensive Review of Overactive Bladder Pathophysiology: On the Way to Tailored Treatment Benoit Peyronnet a,*, Emma Mironska b, Christopher Chapple b, Linda Cardozo c, Matthias Oelke d, Roger Dmochowski e,Ge´rard Amarenco f, Xavier Game´ g, Roger Kirby h, Frank Van Der Aa i, Jean-Nicolas Cornu j a Department of Urology, University Hospital of Rennes, Rennes, France; b Department of Urology, Sheffield Teaching Hospitals, Sheffield, UK; c Department of Urology, St. Antonius Hospital, Gronau, Germany; d Department of Urology, Vanderbilt University, Nashville, TN, USA; e Department of Neurourology, Tenon Hospital, Paris, France; f Department of Urogynaecology, King’s College Hospital, London, UK; g Department of Urology, University Hospital of Toulouse, Toulouse, France; h The Prostate Centre, London, UK; i Department of Urology, University of Leuven, Leuven, Belgium; j Department of Urology, University Hospital of Rouen, Rouen, France Article info Abstract Article history: Context: Current literature suggests that several pathophysiological factors and mechanisms might Accepted February 28, 2019 be responsible for the nonspecific symptom complex of overactive bladder (OAB). Objective: To provide a comprehensive analysis of the potential pathophysiology underlying Associate Editor: detrusor overactivity (DO) and OAB. Evidence acquisition: A PubMed-based literature
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