Prevention and Management of Surgical Wound Complications

Total Page:16

File Type:pdf, Size:1020Kb

Prevention and Management of Surgical Wound Complications Foundations of Best Practice for Skin and Wound Management BEST PRACTICE RECOMMENDATIONS FOR THE Prevention and Management of Surgical Wound Complications Connie L. Harris RN MSc ET IIWCC Janet Kuhnke RN BA BScN MSc ET Jennifer Haley BMSc MSC Karen Cross MD PhD FRCSC Ranjani Somayaji BScPT MD FRCPC Jessica Dubois LIT BAH MLIS(c) Richard Bishop RN BScN MN IIWCC Kerstin Lewis RN BSN IIWCC The best practice recommendation articles are special publications of Wound Care Canada. Together they form the Foundations of Best Practice for Skin and Wound Management, an online resource available for free download from the Wounds Canada website (woundscanada.ca). These 2017 updates build on the work of previous author teams and incorporate the latest research and expert opinion. We would like to thank everyone involved in the production of past and present versions of these articles for their hard work, diligence and rigour in researching, writing and producing these valuable resources. Executive Editor: Sue Rosenthal Project Editor: Heather L. Orsted Editorial Assistant: Katie Bassett Copy Editor: Allyson Latta Art Direction and Layout: Robert Ketchen Photo Researcher: Joanne Crone This paper was produced by the Canadian Association of Wound Care (Wounds Canada). The editing and layout were supported by an unrestricted educational grant from Smith & Nephew. woundscanada.ca [email protected] © 2017 Canadian Association of Wound Care All rights reserved. 1534r1E Last updated 2017 02 27. Foundations of Best Practice for Skin and Wound Management BEST PRACTICE RECOMMENDATIONS FOR THE Prevention and Management of Surgical Wound Complications Connie L. Harris RN MSc ET IIWCC Janet Kuhnke RN BA BScN MSc ET Jennifer Haley BMSc MSC Karen Cross MD PhD FRCSC Ranjani Somayaji BScPT MD FRCPC Jessica Dubois LIT BAH MLIS(c) Richard Bishop RN BScN MN IIWCC Kerstin Lewis RN BSN IIWCC Introduction Introduction The Canadian Patient Safety Institute has identified the safety of surgical care as one of its four priority areas.1 According to the Organization for Economic Co-operation and Development, 378,448 surgical procedures were performed in Canada in 2013.2 Surgical procedures can be performed either as inpatient, day surgery with admis- sion of at least one night or, depending on the procedure, in outpatient ambulatory care settings. The final step in the surgical procedure is to close the surgical incision (wound). Many surgical procedures are complex and may carry significant risks for patients regardless of the health-care setting.3 The patient facing surgery brings their own unique individual health history. Some bring excellent health with the expecta- tion of rapid healing, while others have surgery when their complex health history/ issues seriously impair their general recovery and wound healing.4 Seventy-seven percent of surgical patient deaths are reported to be related to infec- tion.5 Infection has a direct correlation to open surgical wounds. Surgical site infection (SSI) is the most common health-care-associated infection among surgical patients. The Centers for Disease Control in the United States reported that while advances have been made in infection control practices, including improved operating room ventilation, sterilization methods, barriers, surgical technique and availability of antimi- crobial prophylaxis, SSI remains a substantial cause of morbidity, prolonged hospitali- zation and death.6 Therefore, recognition of the potential for surgical wound infection may be the most important issue to address when discharge planning for a post-surgi- cal patient.7 In addition, it is estimated that 75% of surgical procedures are performed Foundations of Best Practice for Skin and Wound Management | Best Practice Recommendations for the Prevention and Management of Surgical Wound Complications | 5 on outpatients, making the issues of prevention, detection, treatment and reporting of SSIs in the community or long-term-care sectors essential. For patients who develop an SSI, increased hospital length of stay (LOS) is approximately seven to eight days, while urinary tract infections increase LOS by one to four days, bloodstream infections increase LOS by seven to 30 days and pneumonia increases LOS for seven to 30 days.8 SSIs are of growing concern to the health-care system. SSIs account for 16% of all health-care-associated infections; of these, 1% related to orthopedic procedures and 10% to large bowel surgery. SSIs can often be prevented through initiatives focused on pre-, intra- and post-operative care and education.9,10 The Wound Prevention and Management Cycle This paper offers a practical, easy-to-follow guide incorporating the best available evi- dence that outlines a process, or series of consecutive steps, that supports patient-cen- tred care. This process, called the Wound Prevention and Management Cycle (see Figure 1) guides the clinician through a logical and systematic method for developing a customized plan for the prevention and management of wounds from the initial assessment to a sustainable plan targeting self-management for the patient. 6 | Best Practice Recommendations for the Prevention and Management of Surgical Wound Complications | Foundations of Best Practice for Skin and Wound Management The Wound Prevention and Management Cycle FigureAssess/Reassess 1: The Wound PreventionSet Goals and ManagementAssemble Cycle Team Establish and ImplementEvaluate DOMAIN OF C THE ARE 1 Assess and/or Reassess 2 Set Goals • Assess the patient, the wound (if applicable), as well as environmental and system challenges. • prevention • healing • quality of life and • Identify risk and causative factors that may • non-healing symptom control impact skin integrity and wound healing. • non-healable 5 Evaluate Outcomes Goals Met: Goals Partially Met 3 Assemble the Team • Ensure sustainability. or Not Met: • Select membership based on patient need. Cycle is completed • reassess 4 Establish and Implement a Plan of Care • Establish and implement a plan of care that addresses: • the environment and system • the patient • the wound (if applicable) • Ensure meaningful communication among all members of the team. • Ensure consistent and sustainable implementation of the plan of care. Provide Local Skin/Wound Care (if applicable) Cleansing/ Bacterial Moisture debridement: balance: balance: • Remove debris • Rule out or treat • Ensure adequate and necrotic or superficial/ hydration. indolent tissue, spreading/ if healable. systemic infection. Select appropriate dressing and/or advanced therapy © 2016 CAWC · All rights reserved. The recommendations in this document are based on the best available evidence and © 2016 CAWC · Printed in Canada · v07 · 378E are intended to support the clinician, the patient, his/her family and the health-care team in planning and delivering the best clinical practice. Two foundational papers supplement this document with additional evidence-informed information and rec- Foundations of Best Practice for Skin and Wound Management | Best Practice Recommendations for the Prevention and Management of Surgical Wound Complications | 7 ommendations that are general to all wound types: “Skin: Anatomy, Physiology and Wound Healing,”11 and “Best Practice Recommendations for the Prevention and Man- agement of Wounds.”12 There are three guiding principles within the best practice recommendations (BPRs) that support effective prevention and management of skin breakdown: 1. the use of the Wound Prevention and Management Cycle regardless of the specifics to prevent and manage skin breakdown 2. the constant, accurate and multidirectional flow of meaningful information within the team and across care settings 3. the patient as the core of all decision making Quick Reference Guide The quick reference guide (QRG) (see Table 1) provides the recommendations associ- ated with the five steps in the Wound Prevention and Management Cycle (see Figure 1). These recommendations are discussed with the supporting evidence. Table 1: Wound Prevention and Management Quick Reference Guide Step Recommendation Evidence 1 Assess and/ 1.1 Select and use validated patient assessment tools. RNAO Ia or Reassess 1.2 Identify risk and causative factors that may impact skin integrity and NICE 2/ wound healing. RNAO I–IV 1.2.1 Patient: Physical, emotional and lifestyle 1.2.2 Environmental: Socio-economic, care setting, potential for self- management 1.2.3 Systems: Health-care support and communication 1.3 Complete a wound assessment, if applicable. RNAO IV 2 Set Goals 2.1 Set goals for prevention, healing, non-healing and non-healable wounds. RNAO IV 2.1.1 Identify goals based on prevention or healability of wounds. 2.1.2 Identify quality-of-life and symptom-control goals. 3 Assemble 3.1 Identify appropriate health-care professionals and service providers. NICE 4/RNAO IV the Team 3.2 Enlist the patient and their family and caregivers as part of the team. RNAO IV 3.3 Ensure organizational and system support. RNAO IV 4 Establish 4.1 Identify and implement an evidence-informed plan to correct the causes NICE 2+/RNAO IV and or co-factors that affect skin integrity, including patient needs (physical, Implement emotional and social), the wound (if applicable) and environmental/ a Plan of system challenges. RNAO Ia-III Care 4.2 Optimize the local wound environment aided through 4.2.1 Cleansing 4.2.2 Debriding 4.2.3 Managing bacterial balance 4.2.4 Managing moisture balance RNAO Ia-IV 4.3 Select the appropriate dressings and/or advanced therapy. NICE 4/RNAO
Recommended publications
  • VII. Wound and Fracture Healing
    Journal of Rehabilitation Research and Development Rehabilitation R & D Progress Reports 1986 VII. Wound and Fracture Healing VII . Wound and Fracture Healing Electrical Stimulation for Augmentation of Wound Healing Scott R. Crowgey, M.D., and Steven M. Sharpe Veterans Administration Research and Development, Decatur, GA 30033 Sponsor: VA Rehabilitation Research and Development Service Purpose—This project will attempt to identify ing that could be influenced by electrical stimu- aspects of the wound healing process that may lation. Efforts will then be directed toward de- be augmented by the exogenous influence of veloping mathematical models of the possible electromagnetic fields. A theoretical analysis of electrical interaction of electromagnetic fields the possible effects of electromagnetic fields on with cells and cell structures to determine how wound healing will include analyses of the these interactions could be optimized to im- interaction of electromagnetic fields with cellu- prove wound healing. It is anticipated that the lar structures and of the deposition of heat in literature will not contain all the information damaged tissue via exogenously applied energy necessary to develop these models . Any gaps in fields. This analysis will then be used as a basis necessary information and data will be filled, if for developing a plan for future investigations practical, using tissue phantom modeling mate- into the potential application of electrical stim- rials, blood, and possibly even primitive tissue ulation for the augmentation of wound healing. culture exposed to a variety of known electro- The initial research will involve a review of magnetic environments, using easily construct- the literature to identify aspects of wound heal- ed exposure chambers.
    [Show full text]
  • Wound Care: the Basics
    Wound Care: The Basics Suzann Williams-Rosenthal, RN, MSN, WOC, GNP Norma Branham, RN, MSN, WOC, GNP University of Virginia May, 2010 What Type of Wound is it? How long has it been there? Acute-generally heal in a couple weeks, but can become chronic: Surgical Trauma Chronic -do not heal by normal repair process-takes weeks to months: Vascular-venous stasis, arterial ulcers Pressure ulcers Diabetic foot ulcers (neuropathic) Chronic Wounds Pressure Ulcer Staging Where is it? Where is it located? Use anatomical location-heel, ankle, sacrum, coccyx, etc. Measurements-in centimeters Length X Width X Depth • Length = greatest length (head to toe) • Width = greatest width (side to side) • Depth = measure by marking the depth with a Q- Tip and then hold to a ruler Wound Characteristics: Describe by percentage of each type of tissue: Granulation tissue: • red, cobblestone appearance (healing, filling in) Necrotic: • Slough-yellow, tan dead tissue (devitalized) • Eschar-black/brown necrotic tissue, can be hard or soft Evaluating additional tissue damage: Undermining Separation of tissue from the surface under the edge of the wound • Describe by clock face with patients head at 12 (“undermining is 1 cm from 12 to 4 o’clock”) Tunneling Channel that runs from the wound edge through to other tissue • “tunneling at 9 o’clock, measuring 3 cm long” Wound Drainage and Odor Exudate Fluid from wound • Document the amount, type and odor • Light, moderate, heavy • Drainage can be clear, sanguineous (bloody), serosanguineous (blood-tinged),
    [Show full text]
  • Suturing with U-Technique Versus Un
    Official Title of the Study: Suturing with U-Technique versus Un- Reapproximated wound Edges during removal of Closed Thoracostomy-tube drain - A single centre Open-label randomized prospective trial (SUTURE TRIAL) NCT NUMBER: Not Yet Assigned DATE OF DOCUMENT: January 16, 2019 1 STUDY SUMMARY Title: Suturing with U-Technique versus Un-Reapproximated wound Edges during removal of Closed Thoracostomy-tube drain - A single centre Open-label randomized prospective trial (SUTURE TRIAL) Background: Closed thoracostomy tube drainage or chest tube insertion is one of the most commonly performed procedures in thoracic surgery. There are several published evidence-based guidelines on safe performance of a chest tube insertion. However, there is absence of prospective controlled trials or systematic reviews indicating the safest technique of closing the wound created at the time of chest tube insertion and that best guarantees good wound and overall outcomes, post-chest tube removal. The use of a horizontal mattress non-absorbable suture or U- suture which is placed at the time of chest tube insertion and used to create a purse-string wound re-approximation at the time of tube removal has been an age-long and time-honored practice in most thoracic surgical settings. It has been established by a recent study that an occlusive adhesive-absorbent dressing can also be safely used to occlude the wound at the time of chest tube removal with good wound and overall outcomes though the study focused on tubes inserted during thoracic surgical operations.
    [Show full text]
  • Biology of Bone Repair
    Biology of Bone Repair J. Scott Broderick, MD Original Author: Timothy McHenry, MD; March 2004 New Author: J. Scott Broderick, MD; Revised November 2005 Types of Bone • Lamellar Bone – Collagen fibers arranged in parallel layers – Normal adult bone • Woven Bone (non-lamellar) – Randomly oriented collagen fibers – In adults, seen at sites of fracture healing, tendon or ligament attachment and in pathological conditions Lamellar Bone • Cortical bone – Comprised of osteons (Haversian systems) – Osteons communicate with medullary cavity by Volkmann’s canals Picture courtesy Gwen Childs, PhD. Haversian System osteocyte osteon Picture courtesy Gwen Childs, PhD. Haversian Volkmann’s canal canal Lamellar Bone • Cancellous bone (trabecular or spongy bone) – Bony struts (trabeculae) that are oriented in direction of the greatest stress Woven Bone • Coarse with random orientation • Weaker than lamellar bone • Normally remodeled to lamellar bone Figure from Rockwood and Green’s: Fractures in Adults, 4th ed Bone Composition • Cells – Osteocytes – Osteoblasts – Osteoclasts • Extracellular Matrix – Organic (35%) • Collagen (type I) 90% • Osteocalcin, osteonectin, proteoglycans, glycosaminoglycans, lipids (ground substance) – Inorganic (65%) • Primarily hydroxyapatite Ca5(PO4)3(OH)2 Osteoblasts • Derived from mesenchymal stem cells • Line the surface of the bone and produce osteoid • Immediate precursor is fibroblast-like Picture courtesy Gwen Childs, PhD. preosteoblasts Osteocytes • Osteoblasts surrounded by bone matrix – trapped in lacunae • Function
    [Show full text]
  • Spinal Cord Injury Guidelines 2018
    SPINAL CORD INJURY GUIDELINES 2018 Department of Physical Medicine and Rehabilitation/Trauma Rehabilitation Resources Program TELE-REHABILITATION GUIDELINE Pressure Ulcers Author(s): Peer Reviewed: Finalized: April 2018 Drafted: February 2014 Date: Published: May 2018 I. Definition, assessment, and diagnosis A. Definition 1. Pressure ulcers are sores caused by ischemia due to elevated or prolonged pressure to the skin and underlying tissue, and occur most often over bony prominences. 2. The injury occurs as a result of intense and/or prolonged pressure or pressure in combination with shear. 3. The tolerance of soft tissue for pressure and shear may also be affected by microclimate, nutrition, perfusion, co-morbidities and condition of the soft tissue. 4. There are numerous grading systems but one widely used system is the National Pressure Ulcer Advisory Panel (NPUAP) pressure ulcer stages. 1 In this system the stage is determined by the depth of the tissue damage observed and is used primarily for initial assessment of a pressure ulcer. a. Stage 1 Pressure Injury: Non-blanchable erythema of intact skin: Intact skin with a localized area of non-blanchable erythema, which may appear differently in darkly pigmented skin. Presence of blanchable erythema or changes in sensation, temperature, or firmness may precede visual changes. Color changes do not include purple or maroon discoloration; these may indicate deep tissue pressure injury. b. Stage 2 Pressure Injury: Partial-thickness skin loss with exposed dermis: Partial-thickness loss of skin with exposed dermis. The wound bed is viable, pink or red, moist, and may also present as an intact or ruptured serum-filled blister.
    [Show full text]
  • Products & Technology Wound Inflammation and the Role of A
    Products & technology Wound inflammation and the role of a multifunctional polymeric dressing Temporary inflammation is a normal response in acute wound healing. However, in chronic wounds, the inflammatory phase is dysfunctional in nature. This results in delayed healing, and causes further problems such as increased pain, odour and Intro high levels of exudate production. It is important to choose a dressing that addresses all of these factors while meeting the patient’s needs. Multifunctional polymeric Authors: Keith F Cutting membrane dressings (e.g. PolyMem®, Ferris) can help to simplify this choice and Authors: Peter Vowden assist healthcare professionals in chronic wound care. The unique actions of xxxxx Cornelia Wiegand PolyMem® have been proven to reduce and prevent inflammation, swelling, bruising and pain to promote rapid healing, working in the deep tissues beneath the skin[1,2]. he mechanism of acute wound healing — the vascular and cellular stages. During is a well-described complex cellular vascular response, immediately on injury there is T interaction[3] that can be divided into an initial transient vasoconstriction that can be several integrated processes: haemostasis, measured in seconds. This is promptly followed inflammation, proliferation, epithelialisation by vasodilation under the influence of histamine and tissue remodeling. Inflammation is a key and nitric oxide (NO) that cause an inflow of blood. component of acute wound healing, clearing An increase in vascular permeability promotes damaged extracellular matrix, cells and debris leakage of serous fluid (protein-rich exudate) into from zones of tissue damage. This is normally a the extravascular compartment, which in turn time-limited orchestrated process. Successful increases the concentration of cells and clotting progression of the inflammatory phase allows factors.
    [Show full text]
  • Integumentary Changes and Considerations Impacting People
    Integumentary Changes and Considerations Impacting People with Spinal Cord Injury Authors: Eddie Monroy, PT, DPT, CLW, CWS Why should PTs be concerned about skin for Fact Sheet patients with spinal cord injury? Changes to the skin in patients with SCI (listed below), combined with skin changes common due to aging and other co-morbidities, can make the SCI population at a Produced by very high risk for skin breakdown and pressure injury. Patients with sensory and motor complete injuries are more susceptible to breakdown; however people with 4 incomplete injuries can still be at high risk, especially when medically unstable. o Decreased blood flow, supply, pressure o Decreased amino acid concentration o Decreased enzymes for biosynthesis o Potential change in gene expression o Decreased Adrenergic receptors o (norepinephrine, epinephrine) o Decreased proportion of Type I to Type III collagen fibers o Increased collagen catabolism (dermis) o Decreased Partial Pressure of Oxygen (PO2) a Special Interest What types of skin injuries are most common in SCI? Group of Pressure ulcers/injuries are the most common types of wounds for patients with SCI. They form over bony prominences such the sacrum, ischial tuberosities, greater trochanters, and heels secondary to lack of mobility and blood flow to the areas. It’s important to perform manual skin checks (palpation) in addition to visual skin checks, to note a change in tissue quality (induration / boggy); as signs of potential breakdown may show up before visual signs are noted. Teaching staff and caregivers how to perform these manual and visual checks daily is an integral part of the patient’s overall SCI education and future health.
    [Show full text]
  • Pressure Ulcer Prevention and Treatment Following Injury: a Clinical Practice Guideline for Health-Care Providers
    SPINAL CORD MEDICINE PRESSURE PRESSURE ULCER Pressure Ulcer Prevention and Treatment Following Spinal Cord Injury: A Clinical Practice Guideline for Health-Care Professionals SECOND EDITION CLINICAL PRACTICE GUIDELINE: Administrative and financial support provided by Paralyzed Veterans of America Consortium for Spinal Cord Medicine Member Organizations Academy of Spinal Cord Injury Professionals Nurses Section Psychologists and Social Workers Section Physicians Section American Academy of Orthopedic Surgeons American Academy of Physical Medicine and Rehabilitation American Association of Neurological Surgeons American Association of Spinal Cord Injury Nurses American College of Emergency Physicians American Congress of Rehabilitation Medicine American Occupational Therapy Association American Physical Therapy Association American Psychological Association, Division 22 American Spinal Injury Association Association of Academic Physiatrists Association of Rehabilitation Nurses Christopher and Dana Reeve Foundation Insurance Rehabilitation Study Group International Spinal Cord Society Paralyzed Veterans of America Rick Hansen Institute Society of Critical Care Medicine U. S. Department of Veterans Affairs United Spinal Association CLINICAL PRACTICE GUIDELINE Spinal Cord Medicine Pressure Ulcer Prevention and Treatment Following Injury: A Clinical Practice Guideline for Health-Care Providers SECOND EDITION Consortium for Spinal Cord Medicine Administrative and financial support provided by Paralyzed Veterans of America © Copyright 2014, Paralyzed Veterans of America This guideline has been prepared based on scientific and professional information available in 2014. Users of this guideline should periodically review this material to ensure that the advice herein is consistent with current reasonable clinical practice. The websites noted in this document were current at the time of publication; however, because web addresses and the information contained therein change frequently, the reader is encouraged to stay apprised of the most current information.
    [Show full text]
  • A Guide to Post-Operative Wound Care
    A PART OF Education to improve your practice Surgical Wound Management: A Guide to Post-Operative Wound Care SPONSORED BY OCTOBER 2018 WoundCopyright Infection © 2018 Diagnosis WoundSource and Management & Kestrel Health / © Information, 2018 Kestrel Inc. Health All rights Information, reserved. Inc. www.woundsource.com / 1 A part of Surgical Wound Management: A Guide to Post-Operative Wound Care Introduction and Background Millions of patients undergo surgical procedures every year. Advances in surgical techniques afford patients increased access to minimally invasive techniques, allowing avoidance of the need for traditional “open” surgical incisions. However, many procedures performed may still require a larger incision or may involve an existing open wound of varying chronicity. Failure to heal, including wound dehiscence and surgical site infections (SSIs), is the most common major complication related to surgical wound management, and monitoring for conditions related to this failure is crucial during the immediate (three- to four-week) post-operative period.1 The impact of SSI is widespread, affecting the patient, caregivers, the treatment team, and the health care system as a whole. SSIs are challenging because of their multifactorial development. For patients who go on to develop SSI after a surgical procedure, length of stay can be increased by up to two weeks, and overall treatment costs average nearly $35,000 per incident. The most common wound-related consequence of SSI is dehiscence, for which wound management modalities such as debridement and advanced dressings may be used to expedite healing. WoundA PART OF Infection Diagnosis and Management / © 2018 Kestrel Health Information, Inc. www.woundsource.com / 2 Surgical Wound Management: A Guide to Post-Operative Wound Care A part of Copyright © 2018 WoundSource & Kestrel Health Information, Inc.
    [Show full text]
  • Wound Healing SEP 2019
    www.treatnow.org September 2019 WOUND HEALING EXECUTIVE SUMMARY: Traditional medicine does not treat the physical wound to the brain. After a decade and a half of merely treating symptoms, DOD/VA lament the rise in suicides across the services. After billions spent on drugs, computer and device interventions, and questionable treatments, a suicide epidemic afflicts service members. Yet not one of the 80+ therapies/processes/procedures/devices, countless computer applications, and 114+ prescribed drugs has been approved by the FDA for TBI, nor do they "treat" wounds. All are used off-label for TBI. All are controversial at some level. Many of them are brand-new and haven't even been explored in the literature. No risk analysis has been performed, and no tracking is done. Yet neither the DOD nor the VA provide Hyperbaric Oxygen Therapy to treat and heal brain injury. HBOT is the one therapy proved by multiple clinical trials inside DOD/VA, across the US, and around the world to treat and help heal the wound to the brain, safely and effectively. ****************** A wound will not heal without ENERGY and OXYGEN. A brain wound leads immediately to a “concussion cascade”, a negative flow of adverse consequences that may lead to truly bad effects over time: diseases like Chromic Traumatic Encephalopathy (CTE), Alzheimer’s, and other neurologic disorders. Symptoms may abate, but idling neurons may not recover without application of additional oxygen and energy delivered directly to the brain. The use of Hyperbaric Oxygen addresses directly this negative cascade of damage and degeneration both in the acute phase of wound stabilization and in the acute and chronic phases of wound healing.
    [Show full text]
  • Guideline: Assessment & Treatment of Surgical Wounds
    British Columbia Provincial Nursing Skin and Wound Committee Guideline: Assessment and Treatment of Surgical Wounds Healing by Primary and Secondary Intention in Adults & Children Developed in collaboration with the Wound Care Clinicians from: / TITLE Guideline: Assessment & Treatment of Surgical Wounds Healing by Primary and Secondary Intention in Adults & Children Practice Level Nurses in accordance with health authority / agency policy. Clients with surgical wounds require an interprofessional approach to provide comprehensive, evidence-based assessment and treatment. This clinical practice guideline focuses solely on the role on the nurse, as one member of the interprofessional team providing care to these clients. Background Surgical wounds normally heal by primary intention or closure using sutures, staples or tapes. Sutures and staples should be left in place long enough to ensure there is sufficient tissue strength to hold the incision together without support. Timing of suture and staple removal varies based on the stage of healing and the location and extent of the incision. However, sutures left in too long can cause scarring and infection. Wounds may heal by secondary intention if there is a risk of severe contamination or if tissue loss is such that skin edges cannot be approximated. Surgical wounds left to heal by secondary intention have a healing pattern similar to chronic wounds and healing is evaluated using similar criteria. Wounds may also heal by delayed primary intention when there is a known risk of infection or the client’s condition prevents primary closure, e.g. edema at the site. Surgical wounds are classified as clean, clean-contaminated, contaminated and dirty-infected.
    [Show full text]
  • The Far-Reaching Scope of Neuroinflammation After Traumatic Brain Injury
    REVIEWS The far-reaching scope of neuroinflammation after traumatic brain injury Dennis W. Simon1, Mandy J. McGeachy2, Hülya Bayır1, Robert S. B. Clark1, David J. Loane3 and Patrick M. Kochanek4 Abstract | The ‘silent epidemic’ of traumatic brain injury (TBI) has been placed in the spotlight as a result of clinical investigations and popular press coverage of athletes and veterans with single or repetitive head injuries. Neuroinflammation can cause acute secondary injury after TBI, and has been linked to chronic neurodegenerative diseases; however, anti-inflammatory agents have failed to improve TBI outcomes in clinical trials. In this Review, we therefore propose a new framework of targeted immunomodulation after TBI for future exploration. Our framework incorporates factors such as the time from injury, mechanism of injury, and secondary insults in considering potential treatment options. Structuring our discussion around the dynamics of the immune response to TBI — from initial triggers to chronic neuroinflammation — we consider the ability of soluble and cellular inflammatory mediators to promote repair and regeneration versus secondary injury and neurodegeneration. We summarize both animal model and human studies, with clinical data explicitly defined throughout this Review. Recent advances in neuroimmunology and TBI-responsive neuroinflammation are incorporated, including concepts of inflammasomes, mechanisms of microglial polarization, and glymphatic clearance. Moreover, we highlight findings 1Department of Critical Care that could
    [Show full text]