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Yale Medicine Magazine Yale Medicine P.O. Box 7612, New Haven CT 06519-0612 Non-Profit Org. U.S. Postage PAID New Haven, CT Permit No. 470 Yale MedicineFall 2000 | Winter 2001 s Biotech Boom ’ Yale Medicine Yale Fall 2000 | Winter 2001 2000 Winter Fall | New Haven 16 The ribosome resolved | 22 New Haven neighbors | 42 After the genome contents 2 Letters 4 Chronicle 12 Rounds 16 Findings 19 On Campus 20 Capsule 22 Neighbors Photographs prepared for Yale’s Tercentennial celebration explore the work of health professionals and students and their partners in the community. By John Curtis On the cover Yale Medicine Already home to five publicly traded Alumni Bulletin of the biotechnology companies, greater Yale University School of Medicine Fall 2000 | Winter 2001 New Haven has seen the formation of 32 Volume 35, No. 1 New Haven’s biotech boom eight new startups as the result of the University's recent efforts to pro- Editor-in-Chief The medical school’s efforts to bring its intellectual mote application of its technology Michael Kashgarian, M.D. Professor of Pathology and Biology and encourage growth in the city's property to market have given the New Haven biotech sector.Close to a dozen more Publisher economy a boost. companies are being formed around Jane E. Reynolds By Marc Wortman Yale discoveries.This emerging indus- Associate Dean try is increasingly information-driven, Editor using massive computing power and Michael Fitzsousa microarray technology (right), for Director of Publications 42 After the genome example, to harness genetic informa- Associate Editor tion in the search for new diagnostic John Curtis The year brought the working-draft version tests and therapies.Page 32. Contributing Editors of the human genome and new hopes for medicine Sandra J. Ackerman and the understanding of human biology. Genetics Cover Illustrations Sharon McManus Karen Peart Aerial view of New Haven: Chair Richard Lifton talks about what that means United States Geological Survey Jacqueline Weaver for research, at Yale and around the world. Marc Wortman, Ph.D. DNA microarray: Interview by Michael Fitzsousa Kevin White/Department of Genetics Copy Editing Anne Sommer Office Manager / Editorial Assistant Claire M. Bessinger 48 Faculty News Senior Administrative Assistant Cheryl R. Violante 56 Student News Design Peter Johnson and Daphne Geismar 64 Alumni News Yale RIS Graphic Design Printing 68 Reunion 2000 W.E. Andrews of Connecticut Inc. Yale Medicine is distributed to alumni, 78 In Memoriam faculty, students and friends of the School of Medicine, as well as leaders 80 Archives in Yale University alumni activities. Address correspondence to: Editor, Yale Medicine P.O. Box 7612 New Haven, CT 06519-0612 Telephone: 203-785-5824 Facsimile: 203-785-4327 Electronic mail: [email protected] Website: http://info.med.yale.edu/ymm Copyright © 2000-2001 Yale University School of Medicine. All rights reserved. 1 letters from the editor finish could be used? Since I burgdorferi, and its ability to own Sam Kushlan is shown Change is in the air 2000-2001 actually treasure each issue of cloak itself in of the host. in a group photograph. The Association of Yale Alumni Yale Medicine and am sure Evidence of long-term dis- new dean announced that Last year, as we began the process of fine-tuning Yale Medi- in Medicine others must be affected as I ability from inadequate treat- there would be a new med- cine’s content and design to create a more interesting and am, I hope you can find a ment of Lyme disease is ical dormitory built between better-organized magazine, we asked readers for their sugges- Officers .. solution to this devastating documented. And because of the medical school and the tions. Your responses have been an enormous help to us as Gilbert F. Hogan, ’ President problem. the potential for serious dis- new Memorial Unit of the we’ve reviewed both what we report and how we present it ability, I believe treatment hospital. There was a memo- Frank R. Coughlin Jr., .. ’ Esther A. Savage, YUSN ’ within these pages. guidelines need to be re-exam- rable photo of the Betsy Ross Vice President Midland, Mich. On the content side, we learned that readers want to know gale zucker gale ined. I would also like to see tea room. more about the lives of medical students today and more about Francis M. Lobo, .. ’ As it happens, the paper Yale Yale involved in the develop- • Former Dean George Blumer Secretary You’ve come a long way, Eli, what their fellow alumni are doing across the country, the con- Medicine is printed on is ment of more effective antibi- gave a greeting to the new .. in accommodating disability tinent and the globe. They are also interested in the past. By far, Nicholas M. Passarelli, ’ , ’ changing this issue along with otics for Lyme disease. Bulletin (with his photo). the greatest number of letters from readers has come in Past President To the editor: other aspects of our design Your article states that • Markle Foundation awards response to articles about the history of medicine at Yale—for Executive Committee Cathy Shufro’s piece on gradu- (See From the Editor, opposite “Lyme disease has been a were announced to Drs. example, the early use of penicillin that was the subject of a Susan J. Baserga, .. ’, h.. ’ ate student Matthew Weed page.) The glare is gone! lightning rod for controversy Don Shedd and Bill Anlyan. recent article. Arthur C. Crovatto, .. ’, ’ [“Bringing Science Into for years.” My expectation is • At the memorial service for As a result of the comments we received, we are shedding .. Focus,” Summer ] was Debate on Lyme therapy that Yale will provide accurate Dean Francis Blake (June , more light on student life and educational issues today—as Mary V. Digangi, ’ .. inspiring. I was particularly should continue and balanced information on ) the first scholarship in well as on the school’s past. We’ve devoted extra space to sto- Robert J. Kerin, ’ , ’ pleased to read it as my hus- both viewpoints regarding his name was awarded to Dwight F. Miller, .. ’, ’ To the editor: ries about teaching and have started a regular historical band works with a man who short-term and long-term Gerald Klatskin. Donald E. Moore, .. ’, ... ’ The Lyme disease article on department, Capsule, which in this issue explores medicine in was denied entry to Yale Col- treatment. Romeo A. Vidone, .. ’, ’ page of the summer edition R.W. Breck, M.D. ’45M New Haven during the Civil War years. We’re also launching a lege many years ago because Christine A. Walsh, .. ’ [“Conventional Lyme Treat- Constance A. Bean, M.P.H. ’ Wallingford, Conn. new department, Archives, peeking into the magazine’s early he had suffered a wrestling ment Found Effective,” Wayland, Mass. issues. See page 80 for the first installment. accident in his senior year of Dr. Breck’s suggestion coincides Ex officio Summer ] appears to In addition, Yale Medicine will continue its focus on alumni, . high school and was a para- with our own recent explora- David A. Kessler, . denigrate physicians who use Through the pages of Yale with 14 pages this issue devoted to alumni and reunion news. It Dean plegic. Yale could not accom- tion of the back issues of Yale longer-term antibiotic therapy, Medicine, a colorful past is our goal to help classmates and old friends stay in touch and modate him and revoked his Medicine and a new depart- Sharon R. McManus with the strong message given to spotlight the ways in which they are changing medicine and acceptance. As a graduate, To the editor: ment in the magazine, Archives, Director, Alumni Affairs that “a short-term regimen of the wider world. Please let us know what you and your Yale this story has always saddened Having also read Connecticut which appears for the first time Donald L. Kent, .. ’, ’ antibiotics is adequate to treat School of Medicine colleagues are doing by writing to us at one me. Now, I am heartened to Medicine for many years, I on page of this issue. The Chair, YSM Alumni Fund the disease.” However, the 30- of the addresses below. read about the advances Yale enjoyed the section entitled School of Medicine Alumni Samuel D. Kushlan, .. ’ day limit has been found to be On the design side, readers say they find Yale Medicine has made in accommodating “ years ago in Connecticut Bulletin, which made its debut YSM Bequest and Endowment Officer unrealistic, especially when appealing, engaging and easy to navigate, both in print and on the disabled, both from a Medicine.” The thought in under the editorship of diagnosis and treatment are the Web at http://info.med.yale.edu/ymm. We’ve taken steps Representatives to the physical and technological occurred, “Why not a brief Arthur Ebbert, M.D., was suc- Association of Yale Alumni delayed. Patients and physi- to improve the easy readability of the magazine while keeping standpoint, as well as from a note each issue about ‘ years ceeded by Yale Medicine in the Daniel L. Arons, .. ’ cians will not accept that con- the design lively. Readers will notice a new paper stock this humanistic one. ago in Yale Medicine’?” fall of . We will mine both Joseph F.J. Curi, .. ’ tinuing symptoms are due to issue, and the overall design of Yale Medicine has been modi- Thank you for your contin- After reviewing my stacks sources for interesting nuggets Deborah Dyett Desir, .. ’, ’ “post-Lyme syndrome.” fied to be consistent with the school’s new printed materials ued efforts to make Yale of Yale Medicine I found Vol. from the school’s past. Nationwide evidence sup- for the offices of Admissions and Development (See page 10).
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