1. Name of the Medicinal Product 2. Qualitative And
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Appendix a Common Abbreviations Used in Medication
UNIVERSITY OF AMSTERDAM MASTERS THESIS Impact of Medication Grouping on Fall Risk Prediction in Elders: A Retrospective Analysis of MIMIC-III Critical Care Database Student: SRP Mentor: Noman Dormosh Dr. Martijn C. Schut Student No. 11412682 – SRP Tutor: Prof. dr. Ameen Abu-Hanna SRP Address: Amsterdam University Medical Center - Location AMC Department Medical Informatics Meibergdreef 9, 1105 AZ Amsterdam Practice teaching period: November 2018 - June 2019 A thesis submitted in fulfillment of the requirements for the degree of Master of Medical Informatics iii Abstract Background: Falls are the leading cause of injury in elderly patients. Risk factors for falls in- cluding among others history of falls, old age, and female gender. Research studies have also linked certain medications with an increased risk of fall in what is called fall-risk-increasing drugs (FRIDs), such as psychotropics and cardiovascular drugs. However, there is a lack of consistency in the definitions of FRIDs between the studies and many studies did not use any systematic classification for medications. Objective: The aim of this study was to investigate the effect of grouping medications at different levels of granularity of a medication classification system on the performance of fall risk prediction models. Methods: This is a retrospective analysis of the MIMIC-III cohort database. We created seven prediction models including demographic, comorbidity and medication variables. Medica- tions were grouped using the anatomical therapeutic chemical classification system (ATC) starting from the most specific scope of medications and moving up to the more generic groups: one model used individual medications (ATC level 5), four models used medication grouping at levels one, two, three and four of the ATC and one model did not include med- ications. -
Description Price NDC CABLE PULSE OX (4083) 0 DERMABOND(DNX12) (SEE MIKE) 0 HO-CEMENTED STEM SZ 16 71316216 10671.26 NECK METHA MOD
Description Price NDC CABLE PULSE OX (4083) 0 DERMABOND(DNX12) (SEE MIKE) 0 HO-CEMENTED STEM SZ 16 71316216 10671.26 NECK METHA MOD. 130DEG./7.5 L NC077K 8451.29 NECK METHA MOD. 130DEG/7.5 L-R NC079K 8400.06 NEEDLE HOLDER WEBSTER P0405 0 POLYP ETRAP 00711099 1202.32 SET CLEANING BRUSHES 0 TIDISHIELD FRAMES/LENS 9210A-100 0 #1613 VENTILATOR CIR 20.01 #1627 VENTILATOR CIR 21.39 #9 WINDOW ENVELOPE(LAB) 0 * 0 ** 3A ANDROSTANEDIOL GLUCURONIDE 345.81 ** ALKALINE PHOSPHATASE (FRAC) 70.66 ** ALKALINE PHOSPHATASE (FRAC) 99.51 ** CSF3R EXON 14/17 MUTATION 787.47 ** FCM EACH ADDITIONAL MARKER 19.76 ** FECAL ALPHA-1 ANTIRYPSIN 183.16 ** FLOW CYTO INTER/REPT 2 TO 8 MARKERS 115.37 ** TRICYCLIC ANTIDEPRESSANTS QNT UR 227.87 ** URINE PHOSPHORUS ASSAY 70.66 **% DELTA 2 HR 0 **% DELTA 4 HR 0 **% DELTA 6 HR 0 **(RI ANTIBODY WESTERN BLOT ATHENA 246.62 *****UR MICROSCOPIC ONLY 61.69 *****URINALYSIS CANCELLATION NOTICE 0 *****URINALYSIS,BIOCHEM REQUEST 0 *****URINALYSIS,BIOCHEM REQUEST 0 ****2HR URINE CREATININE 70.66 ****CHLAMYDIA PNEUMONIAE AB IGG 79.32 ****HLA TYPING FOR CELIAC DISEASE 0 ****PLATELET AB SERUM 250.95 ****PLATELET PHERESIS LEUKO RED IRRAD 2787.85 ****VMA-SERUM 294.23 ***ANAPLASMA AMP DNA PROBE 469.17 ***BLEEDING TIME 62.02 ***HLA-B27 DNA TYPING 0 ***HSV AB IGM 197.59 ***IGG SERUM 172.72 ***IMMUNOGLOBULIN IGA1 SUBCLASS 57.69 ***IMMUNOGLOBULIN IGA2 SUBCLASS 57.69 ***LYME ANTIGEN DETECTION ELISA 167.67 ***LYME IGM ANTIBODY 204.8 ***MOLD ALLERGEN SCREEN 109.61 ***PATHOLOGY GROSS ONLY 0 **1 HR INCUBATION MIX PROGRESSIVE 89.43 **11 DEOXYCORTISOL -
207988Orig1s000
CENTER FOR DRUG EVALUATION AND RESEARCH APPLICATION NUMBER: 207988Orig1s000 RISK ASSESSMENT and RISK MITIGATION REVIEW(S) Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research Office of Surveillance and Epidemiology Office of Medication Error Prevention and Risk Management RISK EVALUATION AND MITIGATION STRATEGY (REMS) REVIEW Date: December 20, 2015 Reviewer(s): Jasminder Kumar, PharmD Division of Risk Management (DRISK) Acting Team Leader: Jamie Wilkins Parker, Pharm.D., DRISK Deputy Director: Reema Mehta, Pharm.D., M.P.H., DRISK Director: Cynthia LaCivita, Pharm.D. Subject: Review evaluates if a REMS is needed for Zurampic (lesinurad) Drug Name: Zurampic (lesinurad) Therapeutic Class: Uricosuric agent Dosage form and route: 200mg tablet for oral administration Application Type/Number: NDA 207988 Applicant/Sponsor: Ardea Biosciences Inc. OSE RCM #: 2015-52 *** This document contains proprietary and confidential information that should not be released to the public. *** 1 Reference ID: 3863300 CONTENTS 1 INTRODUCTION ................................................................................................................... 3 1.1 Product Background ......................................................................................................... 3 1.2 Disease Background ......................................................................................................... 3 1.3 Regulatory History .......................................................................................................... -
Guidelines for Management of Gout. Part 1: Systematic Nonpharmacologic and Pharmacologic Therapeutic Approaches to Hyperuricemia DINESH KHANNA,1 JOHN D
Arthritis Care & Research Vol. 64, No. 10, October 2012, pp 1431–1446 DOI 10.1002/acr.21772 © 2012, American College of Rheumatology SPECIAL ARTICLE 2012 American College of Rheumatology Guidelines for Management of Gout. Part 1: Systematic Nonpharmacologic and Pharmacologic Therapeutic Approaches to Hyperuricemia DINESH KHANNA,1 JOHN D. FITZGERALD,2 PUJA P. KHANNA,1 SANGMEE BAE,2 MANJIT K. SINGH,3 TUHINA NEOGI,4 MICHAEL H. PILLINGER,5 JOAN MERILL,6 SUSAN LEE,7 SHRADDHA PRAKASH,2 MARIAN KALDAS,2 MANEESH GOGIA,2 FERNANDO PEREZ-RUIZ,8 WILL TAYLOR,9 FRE´ DE´ RIC LIOTE´ ,10 HYON CHOI,4 JASVINDER A. SINGH,11 NICOLA DALBETH,12 SANFORD KAPLAN,13 VANDANA NIYYAR,14 DANIELLE JONES,14 STEVEN A. YAROWS,15 BLAKE ROESSLER,1 GAIL KERR,16 CHARLES KING,17 GERALD LEVY,18 DANIEL E. FURST,2 N. LAWRENCE EDWARDS,19 BRIAN MANDELL,20 H. RALPH SCHUMACHER,21 MARK ROBBINS,22 2 7 NEIL WENGER, AND ROBERT TERKELTAUB Guidelines and recommendations developed and/or endorsed by the American College of Rheumatology (ACR) are intended to provide guidance for particular patterns of practice and not to dictate the care of a particular patient. The ACR considers adherence to these guidelines and recommendations to be voluntary, with the ultimate determi- nation regarding their application to be made by the physician in light of each patient’s individual circumstances. Guidelines and recommendations are intended to promote beneficial or desirable outcomes but cannot guarantee any specific outcome. Guidelines and recommendations developed or endorsed by the ACR are subject to periodic revision as warranted by the evolution of medical knowledge, technology, and practice. -
Colchicine and Probenecid | Memorial Sloan Kettering Cancer Center
PATIENT & CAREGIVER EDUCATION Colchicine and Probenecid This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider. What is this drug used for? It is used to prevent gouty arthritis. What do I need to tell my doctor BEFORE I take this drug? For all patients taking this drug: If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had. If you have any of these health problems: Blood problems or kidney stones. If you have any of these health problems: Kidney disease or liver disease. If you are pregnant or may be pregnant. Do not take this drug if you are pregnant. If you are taking a salicylate drug like aspirin. If you have liver or kidney problems and you take certain other drugs. Very bad and sometimes deadly side effects have happened in these people. There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure. Children: If the patient is a child younger than 2 years of age. Do not give this drug to a child younger than 2 years of age. Colchicine and Probenecid 1/6 This is not a list of all drugs or health problems that interact with this drug. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. -
Lesinurad Cuts Uric Acid in Refractory Gout
20 ARTHRITIS AUGUST 2011 • RHEUMATOLOGY NEWS Lesinurad Cuts Uric Acid in Refractory Gout Ninety percent of patients who remained on fore the end of this year, said Barry D. a uric acid transporter molecule in the Quart, Pharm.D., president of Ardea kidney that takes uric acid out of urine treatment for 28 weeks met the study’s target level. Biosciences, the San Diego–based com- and places it back into the blood. pany that is developing the drug. The study led by Dr. Perez-Ruiz en- BY MITCHEL L. ZOLER mg/day of lesinurad also appeared safe, The phase III study will likely focus on rolled patients who met the 1977 gout di- with no adverse effects or other safety the 200-mg and 400-mg/day dosages, as agnosis criteria of the American FROM THE ANNUAL EUROPEAN CONGRESS OF RHEUMATOLOGY concerns seen during the limited treat- over time most patients appeared to re- Rheumatism Association (now the ment period reported, said Dr. Perez- spond to these lower dosages. American College of Rheumatology) LONDON – An investigational drug Ruiz, a rheumatologist at Hospital de “Almost no one needs 600 mg/day to and who had a serum uric acid level that boosts uric acid secretion led to sig- Cruces in Barakaldo, Spain. get a response,” Dr. Quart said in an in- greater than 6 mg/dL despite being on terview. a stable dose of 200-600 mg allopurinol Major Finding: After 4 weeks of treatment with a combination of 200-600 Although the current study used pa- for at least 6 weeks. -
Gout Management in Swiss Primary Care – a Retrospective Observational Study
Zurich Open Repository and Archive University of Zurich Main Library Strickhofstrasse 39 CH-8057 Zurich www.zora.uzh.ch Year: 2020 Gout management in Swiss primary care - a retrospective observational study Meier, Rahel ; di Gangi, Stefania ; Valeri, Fabio ; Rosemann, Thomas ; Zechmann, Stefan Abstract: BACKGROUND Gout is the most common form of inflammatory arthritis worldwide and its prevalence is rising. In Switzerland, there are no data available on the characteristics and treat- ment of gout patients. In this study, we aimed to describe numbers of patients affected by gout and hyperuricaemia and unveil approaches Swiss primary care physicians (PCPs) use for the management. METHODS This was a retrospective observational study using electronic medical routine nbsp;data pro- vided from 242 Swiss PCPs. Included were all their patients receiving urate-lowering therapy (ULT), with a diagnostic code for gout or who had a serum uric acid (SUA) measurement. According to their disease status, patients were classified into four subgroups (normal urate, hyperuricaemia, untreated gout, treated gout). For treatment analysis, patients with SUA measurements before and after ULT initiation were in- cluded. Comorbidities and risk factors for secondary causes relevant in the context of gout were collected. Outcomes were prevalence of gout and hyperuricaemia, characteristics of patients according to subgroup, number of SUA measurements, levels of SUA and patients who reached the treatment goal of a SUA level lt;360 micro;mol/l. RESULTS We assessed 15,808 patients and classified them into the subgroups. This yielded a prevalence of 1.0% for gout and 1.2% for hyperuricaemia. 2642 patients were diagnosed with gout of whom 2420 (91.6%) received a ULT. -
Estonian Statistics on Medicines 2016 1/41
Estonian Statistics on Medicines 2016 ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day A ALIMENTARY TRACT AND METABOLISM 167,8985 A01 STOMATOLOGICAL PREPARATIONS 0,0738 A01A STOMATOLOGICAL PREPARATIONS 0,0738 A01AB Antiinfectives and antiseptics for local oral treatment 0,0738 A01AB09 Miconazole (O) 7088 g 0,2 g 0,0738 A01AB12 Hexetidine (O) 1951200 ml A01AB81 Neomycin+ Benzocaine (dental) 30200 pieces A01AB82 Demeclocycline+ Triamcinolone (dental) 680 g A01AC Corticosteroids for local oral treatment A01AC81 Dexamethasone+ Thymol (dental) 3094 ml A01AD Other agents for local oral treatment A01AD80 Lidocaine+ Cetylpyridinium chloride (gingival) 227150 g A01AD81 Lidocaine+ Cetrimide (O) 30900 g A01AD82 Choline salicylate (O) 864720 pieces A01AD83 Lidocaine+ Chamomille extract (O) 370080 g A01AD90 Lidocaine+ Paraformaldehyde (dental) 405 g A02 DRUGS FOR ACID RELATED DISORDERS 47,1312 A02A ANTACIDS 1,0133 Combinations and complexes of aluminium, calcium and A02AD 1,0133 magnesium compounds A02AD81 Aluminium hydroxide+ Magnesium hydroxide (O) 811120 pieces 10 pieces 0,1689 A02AD81 Aluminium hydroxide+ Magnesium hydroxide (O) 3101974 ml 50 ml 0,1292 A02AD83 Calcium carbonate+ Magnesium carbonate (O) 3434232 pieces 10 pieces 0,7152 DRUGS FOR PEPTIC ULCER AND GASTRO- A02B 46,1179 OESOPHAGEAL REFLUX DISEASE (GORD) A02BA H2-receptor antagonists 2,3855 A02BA02 Ranitidine (O) 340327,5 g 0,3 g 2,3624 A02BA02 Ranitidine (P) 3318,25 g 0,3 g 0,0230 A02BC Proton pump inhibitors 43,7324 A02BC01 Omeprazole -
Australian Statistics on Medicines 1997 Commonwealth Department of Health and Family Services
Australian Statistics on Medicines 1997 Commonwealth Department of Health and Family Services Australian Statistics on Medicines 1997 i © Commonwealth of Australia 1998 ISBN 0 642 36772 8 This work is copyright. Apart from any use as permitted under the Copyright Act 1968, no part may be repoduced by any process without written permission from AusInfo. Requests and enquiries concerning reproduction and rights should be directed to the Manager, Legislative Services, AusInfo, GPO Box 1920, Canberra, ACT 2601. Publication approval number 2446 ii FOREWORD The Australian Statistics on Medicines (ASM) is an annual publication produced by the Drug Utilisation Sub-Committee (DUSC) of the Pharmaceutical Benefits Advisory Committee. Comprehensive drug utilisation data are required for a number of purposes including pharmacosurveillance and the targeting and evaluation of quality use of medicines initiatives. It is also needed by regulatory and financing authorities and by the Pharmaceutical Industry. A major aim of the ASM has been to put comprehensive and valid statistics on the Australian use of medicines in the public domain to allow access by all interested parties. Publication of the Australian data facilitates international comparisons of drug utilisation profiles, and encourages international collaboration on drug utilisation research particularly in relation to enhancing the quality use of medicines and health outcomes. The data available in the ASM represent estimates of the aggregate community use (non public hospital) of prescription medicines in Australia. In 1997 the estimated number of prescriptions dispensed through community pharmacies was 179 million prescriptions, a level of increase over 1996 of only 0.4% which was less than the increase in population (1.2%). -
Serum Uric Acid Control for Prevention of Gout Flare in Patients with Asymptomatic Hyperuricaemia: a Retrospective Cohort Study
Inflammatory arthritis Ann Rheum Dis: first published as 10.1136/annrheumdis-2021-220439 on 22 June 2021. Downloaded from EPIDEMIOLOGICAL SCIENCE Serum uric acid control for prevention of gout flare in patients with asymptomatic hyperuricaemia: a retrospective cohort study of health insurance claims and medical check- up data in Japan Ruriko Koto ,1 Akihiro Nakajima,2 Hideki Horiuchi,1 Hisashi Yamanaka3,4,5 Handling editor Josef S ABSTRACT Key messages Smolen Objectives In patients with gout, treating to target serum uric acid levels (sUA) of ≤6.0 mg/dL is universally ► Additional supplemental What is already known about this subject? material is published online recommended to prevent gout flare. However, there is ► For adequate management of gout, guidelines only. To view, please visit the no consensus on asymptomatic hyperuricaemia. Using around the world consistently recommend the journal online (http:// dx. doi. Japanese health insurance claims data, we explored use of urate- lowering therapy (ULT) to maintain org/ 10. 1136/ annrheumdis- potential benefits of sUA control for preventing gout 2021- 220439). serum uric acid levels (sUA) of ≤ 6.0 mg/dL. flare in subjects with asymptomatic hyperuricaemia. 1 Methods This retrospective cohort study analysed the Medical Science Department, What does this study add? Teijin Pharma Limited, Chiyoda- JMDC Claims Database from April 2012 through June In both patients population with asymptomatic ku, Tokyo, Japan 2019. Subjects with sUA ≥8.0 mg/dL were identified, and ► 2Pharmaceutical Development hyperuricaemia and those with gout, our disease status (prescriptions for urate-lowering therapy Administration Department, study indicates that the occurrence of gout (ULT), occurrence of gout flare, sUA) was investigated for Teijin Pharma Limited, Chiyoda- flare can be lowered by using ULT to maintain ku, Tokyo, Japan 1 year. -
Discontinuation of Urate-Lowering Drugs: a Systematic Review Protocol
Discontinuation of urate-lowering drugs: a systematic review protocol Virginie Beslon, Perrine Moreau, Annabel Maruani, Hubert Maisonneuve, Bruno Giraudeau, Jean-Pascal Fournier ADMINISTRATIVE INFORMATION Registration PROSPERO registration number: Review team Virginie Beslon, Département de médecine générale, Université de Nantes, France ; [email protected] Perrine Moreau, Département de médecine générale, Université de Nantes, France ; [email protected] Annabel Maruani, Services de dermatologie, CHRU de Tours, Université François Rabelais, Tours, France ; [email protected] Hubert Maisonneuve, Unité des Internistes Généralistes et Pédiatres, Faculté de Médecine, Université de Genève, Suisse ; [email protected] Bruno Giraudeau, INSERM CIC 1415, CHRU de Tours, Université François-Rabelais, Tours, France ; [email protected] Jean-Pascal Fournier, Département de médecine générale, EA 4275-SPHERE, Université de Nantes, France ; [email protected] Contact details Jean-Pascal Fournier (guarantor) Département de médecine générale, Université de Nantes EA 4275-SPHERE, Biostatistique, Recherche Clinique et Mesures Subjectives en Santé, Université de Nantes 1 rue, Gaston Veil, 44000, Nantes, France [email protected] Contributions 1. Draft the protocol: VB, PM, AM, HM, BG, JPF 2. Study selection: VB, PM, JPF 3. Extract data from studies: VB, PM, JPF 4. Carry out the analysis: VB, PM, JPF 5. Interpret the analysis: VB, PM, AM, HM, BG, JPF 6. Draft the final review: VB, PM, JPF 7. Critical revision of the review for important intellectual content: VB, PM, AM, HM, BG, JPF Anticipated or actual start date December 30, 2015 Anticipated completion date October 30, 2016 Dissemination plans This paper will be submitted to a leading journal in this field. -
Estonian Statistics on Medicines 2013 1/44
Estonian Statistics on Medicines 2013 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A ALIMENTARY TRACT AND METABOLISM 146,8152 A01 STOMATOLOGICAL PREPARATIONS 0,0760 A01A STOMATOLOGICAL PREPARATIONS 0,0760 A01AB Antiinfectives and antiseptics for local oral treatment 0,0760 A01AB09 Miconazole(O) 7139,2 g 0,2 g 0,0760 A01AB12 Hexetidine(O) 1541120 ml A01AB81 Neomycin+Benzocaine(C) 23900 pieces A01AC Corticosteroids for local oral treatment A01AC81 Dexamethasone+Thymol(dental) 2639 ml A01AD Other agents for local oral treatment A01AD80 Lidocaine+Cetylpyridinium chloride(gingival) 179340 g A01AD81 Lidocaine+Cetrimide(O) 23565 g A01AD82 Choline salicylate(O) 824240 pieces A01AD83 Lidocaine+Chamomille extract(O) 317140 g A01AD86 Lidocaine+Eugenol(gingival) 1128 g A02 DRUGS FOR ACID RELATED DISORDERS 35,6598 A02A ANTACIDS 0,9596 Combinations and complexes of aluminium, calcium and A02AD 0,9596 magnesium compounds A02AD81 Aluminium hydroxide+Magnesium hydroxide(O) 591680 pieces 10 pieces 0,1261 A02AD81 Aluminium hydroxide+Magnesium hydroxide(O) 1998558 ml 50 ml 0,0852 A02AD82 Aluminium aminoacetate+Magnesium oxide(O) 463540 pieces 10 pieces 0,0988 A02AD83 Calcium carbonate+Magnesium carbonate(O) 3049560 pieces 10 pieces 0,6497 A02AF Antacids with antiflatulents Aluminium hydroxide+Magnesium A02AF80 1000790 ml hydroxide+Simeticone(O) DRUGS FOR PEPTIC ULCER AND GASTRO- A02B 34,7001 OESOPHAGEAL REFLUX DISEASE (GORD) A02BA H2-receptor antagonists 3,5364 A02BA02 Ranitidine(O) 494352,3 g 0,3 g 3,5106 A02BA02 Ranitidine(P)