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Environmental Health Criteria 64 CARBAMATE PESTICIDES: A

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Environmental Health Criteria 64 CARBAMATE PESTICIDES: A Environmental Health Criteria 64 CARBAMATE PESTICIDES: A GENERAL INTRODUCTION Please note that the layout and pagination of this web version are not identical with the printed version. Carbamate pesticides: a general introduction (EHC 64, 1986) INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY ENVIRONMENTAL HEALTH CRITERIA 64 CARBAMATE PESTICIDES: A GENERAL INTRODUCTION This report contains the collective views of an international group of experts and does not necessarily represent the decisions or the stated policy of the United Nations Environment Programme, the International Labour Organisation, or the World Health Organization. Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization World Health Orgnization Geneva, 1986 The International Programme on Chemical Safety (IPCS) is a joint venture of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization. The main objective of the IPCS is to carry out and disseminate evaluations of the effects of chemicals on human health and the quality of the environment. Supporting activities include the development of epidemiological, experimental laboratory, and risk-assessment methods that could produce internationally comparable results, and the development of manpower in the field of toxicology. Other activities carried out by the IPCS include the development of know-how for coping with chemical accidents, coordination of laboratory testing and epidemiological studies, and promotion of research on the mechanisms of the biological action of chemicals. ISBN 92 4 154264 0 The World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full. Applications and enquiries should be addressed to the Office of Publications, World Health Organization, Geneva, Switzerland, which will be glad to provide the latest information on any changes made to the text, plans for new editions, and reprints and translations already available. Page 1 of 102 Carbamate pesticides: a general introduction (EHC 64, 1986) (c) World Health Organization 1986 Publications of the World Health Organization enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal Copyright Convention. All rights reserved. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. The mention of specific companies or of certain manufacturers' products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. CONTENTS ENVIRONMENTAL HEALTH CRITERIA FOR CARBAMATE PESTICIDES: A GENERAL INTRODUCTION 1. SUMMARY AND RECOMMENDATIONS 1.1. Summary 1.1.1. General 1.1.2. Properties, uses, and analytical methods 1.1.3. Sources, environmental transport and distribution 1.1.4. Environmental levels and exposures 1.1.5. Effects on organisms in the environment 1.1.6. Kinetics and metabolism 1.1.7. Mechanism of toxicity 1.1.8. Effects on experimental animals and in vitro test systems 1.1.9. Mutagenicity and related end-points 1.1.10. Carcinogenicity 1.1.11. Effects on man 1.1.12. Previous evaluations by international bodies 1.2. Recommendations 2. IDENTITY, PHYSICAL AND CHEMICAL PROPERTIES, ANALYTICAL METHODS 2.1. Identity 2.2. Physical and chemical properties 2.3. Analytical methods 3. SOURCES OF HUMAN AND ENVIRONMENTAL EXPOSURE 3.1. Natural occurrence 3.2. Man-made sources 3.2.1. Production levels, processes, and uses 4. ENVIRONMENTAL TRANSPORT, DISTRIBUTION, AND TRANSFORMATION 4.1. Transport and distribution between media 4.1.1. Air 4.1.2. Water 4.1.3. Soil 4.1.4. Vegetation and wildlife Page 2 of 102 Carbamate pesticides: a general introduction (EHC 64, 1986) 4.1.5. Entry into the food chain 4.2. Biotransformation 4.2.1. Microbial degradation 4.2.2. Photodegradation 4.2.3. Photodecomposition in the aquatic environment 5. ENVIRONMENTAL LEVELS AND HUMAN EXPOSURE 5.1. Exposure of the general population 5.1.1. Food and drinking-water 6. METABOLISM AND MODE OF ACTION 6.1. Mode of action 6.1.1. Neuropathy target esterase 6.2. Metabolism 6.2.1. Absorption 6.2.2. Distribution 6.2.3. Metabolic transformation 6.2.3.1 Biotransformation mechanisms 6.2.3.2 Oxidation 6.2.3.3 Hydrolysis 6.3.2.4 Conjugation 6.2.3.5 Examples of biotransformation of carbamates 6.3. Elimination and excretion in expired air, faeces, and urine 6.3.1. Man 6.3.2. Laboratory animals 6.4. Metabolism in plants 7. EFFECTS ON ORGANISMS IN THE ENVIRONMENT 7.1. Microorganisms 7.2. Aquatic Organisms 7.2.1. Field studies 7.3. Terrestrial Organisms 7.3.1. Effects on soil fauna 7.3.2. Wildlife 7.3.3. Bees 7.4. Earthworm and mite populations 8. EFFECTS ON EXPERIMENTAL ANIMALS AND IN VITRO TEST SYSTEMS 8.1. Single exposures 8.1.1. Oral 8.1.2. Dermal 8.1.3. Inhalation 8.2. Short- and long-term exposures 8.2.1. Oral 8.2.1.1 Further information on short- and long-term toxicity 8.2.2. Dermal 8.3. Skin and eye irritation; sensitization 8.3.1. Skin irritation 8.3.2. Eye irritation 8.3.3. Skin sensitization 8.4. Inhalation 8.5. Reproduction, embryotoxicity, and teratogenicity 8.5.1. Reproduction 8.5.2. Endocrine system 8.5.3. Embryotoxicity and teratogenicity 8.6. Mutagenicity and related end-points Page 3 of 102 Carbamate pesticides: a general introduction (EHC 64, 1986) 8.7. Carcinogenicity 8.7.1. General 8.8. Special studies 9. EFFECTS ON MAN 9.1. General population exposure 9.1.1. Acute toxicity: poisoning incidents 9.1.2. Effects of short- and long-term exposure 9.1.3. Controlled human studies 9.2. Occupational exposure 9.2.1. Acute toxicity: poisoning incidents 9.2.2. Effects of short- and long-term exposure 9.2.3. Epidemiological studies 9.3. Signs and symptoms of acute intoxication by carbamates 9.3.1. Biochemical methods for measurement of effects 9.4. Treatment of acute poisoning by carbamate insecticides 9.4.1. Minimizing the absorption 9.4.2. General supportive treatment 9.4.3. Specific pharmacological treatment 9.4.3.1 Atropine 9.4.3.2 Oxime reactivators 9.4.3.3 Diazepam 10. PREVIOUS EVALUATIONS BY INTERNATIONAL BODIES REFERENCES ANNEX I NAMES AND STRUCTURES AND SOME PHYSICAL AND CHEMICAL PROPERTIES OF CARBAMATE PESTICIDES ANNEX II SUMMARY OF THE SHORT- AND LONG-TERM TOXICITY STUDIES THAT WERE USED TO ESTABLISH THE ACCEPTABLE DAILY INTAKES FOR HUMAN BEINGS FOR CARBAMATE COMPOUNDS ANNEX III CARBAMATES: JMPR REVIEWS, ACCEPTABLE DAILY INTAKES, EVALUATION BY IARC, CLASSIFICATION BY HAZARD, FAO/WHO DATA SHEETS, IRPTC DATA PROFILE AND LEGAL FILE ANNEX IV ABBREVIATIONS WHO TASK GROUP ON CARBAMATE PESTICIDES Members Dr D. Ecobichon, Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada Dr A.H. El-Sebae, Department of Pesticide Chemistry, Faculty of Agriculture, University of Alexandria, Alexandria, Egypt Dr L. Ivanova-Chemishanska, Institute of Hygiene and Occupational Health, Medical Academy, Sofia, Bulgaria (Vice-Chairman) Dr M.K. Johnson, Toxicology Unit, Medical Research Council Laboratories, Carshalton, Surrey, United Kingdom Dr S.K. Kashyap, National Institute of Occupational Health, Ahmedabad, India Dr M. Lotti, Institute of Occupational Health, Padua, Italy Dr L. Martson, All-Union Scientific Research Institute of the Page 4 of 102 Carbamate pesticides: a general introduction (EHC 64, 1986) Hygiene and Toxicology of Pesticides, Polymers, and Plastics (VNIIGINTOX), Kiev, USSRa Dr U.G. Oleru, College of Medicine, University of Lagos, Lagos, Nigeria. Dr W.O. Phoon, Department of Social Medicine and Public Health, National University of Singapore, Outram Hill, Republic of Singapore (Chairman) Dr A.F. Rahde, Ministry of Public Health, Porto Alegre, Brazil Dr E. Reiner, Institute for Medical Research and Occupational Health, Zagreb, Yugoslavia Dr J. Sekizawa, National Institute of Hygienic Sciences, Tokyo, Japan Observers Mr R.J. Lacoste, International Group of National Associations of Pesticide Manufacturers (GIFAP), Brussels, Belgium Secretariat Mrs B. Bender, United Nations Environment Programme, International Register of Potentially Toxic Chemicals, Geneva, Switzerland Dr J.R.P. Cabral, Unit of Mechanisms of Carcinogenesis, International Agency for Research on Cancer, Lyons, France --------------------------------------------------------------------------- a Invited, but unable to attend. Secretariat (contd.) Dr K.W. Jager, International Programme on Chemical Safety, World Health Organization, Geneva, Switzerland (Secretary) Dr G.J. Van Esch, Bilthoven, The Netherlands (Temporary Adviser) (Rapporteur) Dr C. Xintaras, Office of Occupational Health, World Health Organization, Geneva, Switzerland NOTE TO READERS OF THE CRITERIA DOCUMENTS Every effort has been made to present information in the criteria documents as accurately as possible without unduly delaying their publication. In the interest of all users of the environmental health criteria documents, readers are kindly requested to communicate any errors that may have occurred to the Manager of the International Programme on Chemical Safety, World Health Organization, Geneva,
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