DOCSLIB.ORG

FY 2014 Annual Progress Report - Energy Storage R&D This Document Highlights Work Sponsored by Agencies of the U.S

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
FY 2014 Annual Progress Report - Energy Storage R&D This Document Highlights Work Sponsored by Agencies of the U.S MARCH 2015 2014 OFFICE OF VEHICLE TECHNOLOGIES FY 2014 Annual Progress Report - Energy Storage R&D This document highlights work sponsored by agencies of the U.S. Government. Neither the U.S. Government nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by the U.S. Government or any agency thereof. The views and opinions of authors expressed herein do not necessarily state or reflect those of the U.S. Government or any agency thereof. U.S. Department of Energy 1000 Independence Avenue, S.W. Washington, D.C. 20585-0121 Fiscal Year 2014 Annual Progress Report for Energy Storage R&D March 2015 Approved by David Howell, Hybrid Electric Systems Program Manager Vehicle Technologies Office, Energy Efficiency and Renewable Energy Table of Contents I. Introduction ............................................................................................................................................................... 1 I.A Vehicle Technologies Office Overview ............................................................................................................ 1 I.B Vehicle Technologies Battery R&D Overview ................................................................................................. 1 I.B.1 DOE Battery R&D Goals and Technical Targets .......................................................................................... 1 I.B.2 DOE Battery R&D Plans ............................................................................................................................... 2 I.B.3 Energy Storage R&D Programmatic Structure .............................................................................................. 3 I.B.4 Recent EV Everywhere Highlights ................................................................................................................ 5 I.B.5 Organization of this Report ........................................................................................................................... 7 II. Advanced Battery Development ........................................................................................................................... 11 II.A USABC Battery Development Projects ......................................................................................................... 15 II.A.1 EV Battery Development (Envia Systems) ................................................................................................ 15 II.A.2 Advanced High-Performance Batteries for Plug-In Hybrid Electric Vehicle Applications (JCI) .................. 19 II.A.3 Development of a High-Performance PHEV Battery Pack (LG Chem, MI) ................................................ 26 II.A.4 Development of a PHEV Battery (Xerion) .................................................................................................. 31 II.A.5 Energy Storage System for High Power LEESS PAHEV Applications (Maxwell Technologies) ................ 35 II.A.6 Development of 12V Start-stop Microhybrid Batteries (Saft) ..................................................................... 38 II.A.7 Development of 12V Start-stop Microhybrid Batteries (Leyden Energy) .................................................... 43 II.A.8 2012 EV Technology Assessment Program (SKI) ..................................................................................... 47 II.A.9 Multifunctional, Inorganic-Filled Separator Development for Large Format Li-ion Batteries (ENTEK) ................................................................................................................................................... 50 II.B Advanced Lithium Battery Cell Technology ................................................................................................. 53 II.B.1 Silicon-nanowire Based Lithium Ion Batteries for Vehicles with Double the Energy Density (Amprius) .................................................................................................................................................. 53 II.B.2 Development of Large Format Lithium-Ion Cells with Higher Energy Density (XALT Energy) ................... 56 II.B.3 Innovative Cell Materials and Designs for 300 Mile Range EVs (OneD Material) ...................................... 60 II.B.4 Advanced High-energy Li-ion Cell for PHEV and EV (3M) ........................................................................ 69 II.B.5 Solid Polymer Batteries for Electric Drive Vehicles (Seeo) ........................................................................ 74 II.B.6 Development of High-Energy Lithium-Sulphur Battery Cells (PSU) ........................................................... 76 II.B.7 Stand Alone Battery Thermal Management System (Denso) .................................................................... 83 II.C Low-cost Processing Research ..................................................................................................................... 87 II.C.1 Low Cost Lithium-ion Cell Manufacturing Project (JCI) ............................................................................. 87 II.C.2 Ultraviolet Curable Binder Lithium-ion Battery Project (Miltec UV International) ....................................... 96 II.C.3 High Capacity Alloy Anodes (Applied Materials) ...................................................................................... 100 II.C.4 Innovative Manufacturing and Materials for Low Cost Lithium-ion Batteries (Optodot Corporation) ....... 104 FY 2014 Annual Progress Report for Energy Storage R&D i Table of Contents II.C.5 Dry Process Electrode Fabrication (Navitas) ........................................................................................... 107 II.D Small Business Innovative Research Projects ........................................................................................... 111 III. Battery Testing, Analysis, and Design .............................................................................................................. 115 III.A Cost Assessments and Requirements Analysis ....................................................................................... 116 III.A.1 Core BatPaC Development and Implementation (ANL) .......................................................................... 116 III.A.2 Battery Ownership Model: A Tool for Evaluating the Economics of Electrified Vehicles and Related Infrastructure (NREL) ................................................................................................................ 121 III.A.3 PEV Battery Second Use (NREL) ........................................................................................................... 125 III.A.4 Battery Life Trade-Off Studies (NREL) ................................................................................................... 128 III.A.5 Battery Production and Recycling Materials Issues (ANL) ...................................................................... 132 III.B Battery Testing Activities ............................................................................................................................ 140 III.B.1 Battery Performance and Life Testing (ANL) .......................................................................................... 140 III.B.2 Battery Performance and Life Testing (INL) ........................................................................................... 143 III.B.3 Battery Abuse Testing (SNL) .................................................................................................................. 148 III.B.4 Battery Thermal Analysis and Characterization Activities (NREL) .......................................................... 155 III.C Battery Analysis and Design Activities ...................................................................................................... 161 III.C.1 Battery Multiscale Multidomain Framework & Modeling (NREL) ............................................................ 161 III.C.2 Computer Aided Engineering of Batteries – CAEBAT (NREL) ............................................................... 165 III.C.3 Computer Aided Engineering of Batteries Effort (ORNL) ........................................................................ 170 III.C.4 Development of Computer Aided Design Tools for Automotive Batteries (GM) ..................................... 174 III.C.5 Development of Computer Aided Design Tools for Automotive Batteries (CD-Adapco) ......................... 182 III.C.6 Development of Computer Aided Design Tools for Automotive Batteries (EC Power) ........................... 186 III.C.7 Coupling of Mechanical Behavior of Cell Components to Electrochemical-Thermal Models for Computer-Aided Engineering of Batteries Under Abuse (NREL, MIT, ANSYS) ..................................... 190 III.C.8 Mechanistic Modeling Framework for Predicting Extreme Battery Response: Coupled Hierarchical Models for Thermal, Mechanical, Electrical and (Electro)chemical Processes (SNL, ORNL, Col School of Mines) .................................................................................................................
Load more

Recommended publications
  • Mineral Glass Crystals
    MINERAL GLASS CRYSTALS 36 pc. Assortment Clear Styrene Storage Box Contains 1 Each of Most Popular Sizes From 19.0 to 32.0 $45.00 72 pc. Assortment Clear Styrene Storage Box Contains 1 Each of Most Popular Available Sizes From 14.0 to 35.0 On All Sizes $90.00 FREE ,_ Special -Oiler With Elt4er A5Sortm,nt UJtraviolefGJQss:Adhesive In Needle P-Omt Tube ' ' ' • • ·- : -- '\. • •!< Perfect fQ~ ~~Glass Ct:ys~ - · ~ fu_~nds in s_w ' ~ u11ravi,olet li~ . S-am~ ~l~ty ?S gia.ss. W & V Crown Assortment Spring Bar Assortment 500 Piece Spring Bar Assortment Crown Assortment Cost You Less Than .1 O Each! for Seiko - Pulsar - Lorus #8501 $44.50 Handy plastic case contains 1O of the most popular numbers used daily - including double flange type used on buckles. Made to fit Seiko, Citizen, Bulova, Pulsar, Lorus and other The most popular crowns both white and yellow are watch cases and bracelets. included in this 24 bottle assortment. There are a total of Ultra thin (1.3mm) 40 crowns. A "must• unit for all stores servicing watches. 100% Stalnless Steel In stock for immediate delivery. Refills available. #PP500 $44.95 Spring Bars by Kreisler 24-HOUR FAX ORDERING 612·452·4298 FREE Information Available *Quartz Movements * Crystals & Fittings * * Resale Merchandise * Findings * Serving The Trade Since 1923 * Stones * Tools & Supplies * VOLUME 16, NUMBER 1 JANUARY 1992 HOROLOGICAL Official Publication of the American Watchmakers Institute Read About Miniature Alice B. Carpenter 2 PRESIDENT'S MESSAGE Enamel Painting Henry B. Fried 4 QUESTIONS & ANSWERS J.G. Tongue Keyless Mechanism 8 Charles Cleves 8 OLD WATCHES Miniature Enamel Painting Archie B.
    [Show full text]
  • Waltham Land Trust
    Waltham Land Trust is a non-profit corporation dedicated to creating a legacy of land conservation in Waltham by promoting, protecting, restoring, and acquiring open space. JOURNAL SPRING 2017 Waltham Then and Now The original commercial center of Waltham was near the Linden Street – Main Street intersection, Marie Daly and businesses spread westward along Main Street, When we drive down Moody Street today, many of a busy thoroughfare for traffic and stagecoaches us are unaware that this busy thoroughfare and dense plying between Boston and Framingham, Worcester neighborhood were once a bucolic farm and abundant and Springfield. By 1830, the business and domestic riverside marshes. Previously a community of farms populace centered along Main, Elm, and River and woodlands, Waltham is now an urban district of Streets near the mill. In the 1830s, Central Street was housing, industries and commercial businesses. Yet developed, and in the following decades, residential and some areas of the city have been preserved as open business growth continued westward along Main Street, space for all to enjoy. This initial article of a series on Felton Street, Charles Street and School Street. Until the changes in Waltham’s environment over the years 1847, when the Moody Street Bridge was built, only a will document one of the first large-scale developments foot bridge on the dam spanned the river near the mill. – the Southside neighborhood. By the 1850s, mill employees and commercial shops The population of Waltham in 1790 was 882, and were expanding southward from Main Street along the vast majority of households were engaged in Moody Street and across the Charles River.
    [Show full text]
  • Portland Daily Press: March 1, 1897
    DAILY PORTLAND~ PRESS.__ PRtC|i: THREE CLtiT8~ PORTLAND. MAINE. MARCH 3. 1897. Waa&gfflBai F.HTAm.TSHUT) JUNE 28. 1862-VOL. 34. MONDaTHORNINQ, In outnumbered the possessions of the two nations. pur- of the mem bars of bis staff, left this although they SHERMAN’S BROTHER. in Suda SANGlilLLn PARDOS suance of this, the commission examined for Washington to attend the THE PEACE OF EUROPE. Christians. A Turkish warship MISCELLANEOUS-__ A SUNDAY SESSION. morning ou international the bombardment of the all available treaties the Senator inauguration of Piesldent MoKinlej. hay today began Major Tells What Be- from Vattel to the present time, in position oooupled by the insurgents. law Thinks. the before it SHOCK KILLED HIM. fore she had done muoh firing, her com- their bearings ou question such examination it mander received word from the represen- In the course of from 28.—A special Kaiser William’s Desire to Preserve that he Was Promised Two Weeks Before attention was directed to the fact tin t Chicago, February Death Under Peculiar Circumstances of tatives of the foreign powers Sher- Senate From Three to Eleven entered into Des Moines says that Major Hoyt Busy or take the conse- the of ths hind Well Known Biddeford Man. must slleuce his guns questions brother of Senator John Sherman Same. time the in- Senate Outburst. discussion between the United States an 1 PIMPLY man, quences. This Is the second a East. He Yesterday Afternoon. in referenoe to the settlement ni has just returned from trip near Suda bay have been fired Spain TO THE surgents who he is of [SPECIAL PRESS.] The thi) boundaries between what is non visited his brother, says on by the Turkish warshir*.
    [Show full text]
  • Horological Times
    The Jewelry Industry's Most Compad and Effldent Leather Strap Book Merchandiser will help you show and sell Men's and Women's Watch Straps! 40 Packages Straps Extra of best selling Remborde' Profits styles, in most popular prices and sizes. 2.6 Keystone The easiest-to-use Over-the-Counter presentation! Closed: 6-1 /2 x 12" x 2-3/4" Men's Book: Bk-525 - All Men's Styles. Open: 3-1 /2" x 12" x 5/ 8" Women's Book: BK-485 - All Women's Styles. Your Net Cost BK525 $264 BK485 $264 TERMS AVAILABLE Waterproof Sklndlver and SportstrapsTM Suggested Retail $2.95 Each. - I I - K-35 Men's Sportstrap (Casio-type); Black. 11 /16" (18mm) K-353 Men's Sportstrap (Casio-type); Black. 13/ 16" (20mm) I K-351 Men's Sportstrap (Casio-type); Black. 3/4" (19mm) K-354 Men's Sportstrap (Casio-type); Black. 13/16" 20mm) - I • - K-352 Men's Sportstrap (Casio-type); Black. 11 / 16" (18mm) K-355 Men's Sportstrap (Casio-type); Black. 3/4" (19mm) ~ P.O. BOX 64561 ST. PAUL. MN 55164 Nellonal WATS - Orders Only 800-328-0205 ~ Esslinger & Cb. Minnesota WATS - Orders Only 800-392-0334 Inquiries - lnlormatlon 612-452-7180 VOLUME12,NUMBER10 OCTOBER 1988 HOROLOGICAL Official Publication of the American Watchmakers Institute ROBERT F. BISHOP PRESIDENT'S MESSAGE 4 AWi Collection Watch #11 Returns "Home" Watch HENRY B. FRIED QUESTIONS & ANSWERS 6 A Watch from Lancashire Returns Home JOE CROOKS BENCH TIPS 8 Another Rust Buster & Retrofitting Dial Feet JAMES H. BROUGHTON WATCHES INSIDE & OUT 12 Using a Heat Gun and Ultraviolet Light To Fit Mineral Crystals LEO A.
    [Show full text]
  • The Rise of the American System of Manufactures in the Private Sector
    Ingenious Yankees: The Rise of the American System of Manufactures in the Private Sector Donald Hoke Milwaukee Public Museum A bald definition of the word "History" would be -- " narrative of events," -- "an account of that which is known to have occurred". But a• ordinarily used, the word is understood to include more than a sim- ple statement of facts, in that there is an attempt to discerncontemporary a• well a• previousconditions, a• affecting the events which are narrated. For the real aim of History should be, not simply to gratify curiosity, but to inform the reader of actions, oc- currences or events which have taken place, in con- nection with, or in consequence of, certain condi- tions, and thereby to serve az a means of instruc- tion, a• well a• of information to the reader. Edward A. Marsh, Master Mechanic, Waltham Watch Company This is a study of the interaction between technology and the market place and the mechanism through which that interaction occurred in the nineteenth century. It concerns the economic and cultural/technological matrix through which mechanics and en- trepreneurs created the private sector of the American System of Manufacturers. The American System of Manufacturers is gener- BUSINESS AND ECONOMIC HISTORY, Second Series, Volume Fourteen, 1985. Copyright(c) 1985 by the Board of Trusteesof the Universityof Illinois. Library of CongressCatalog No. 85-072859. 223 224 ally characterized by the mass production of interchangeable parts on specialized machinery arranged in sequential operation. The examination of four nineteenth century industries -- wooden movement clocks, axes, watches, and typewriters -- traces the development of the American System without government subsidy in any form, either in capital, in transfer of technology, large orders for goods, or tax incentives.
    [Show full text]
  • CHRONO TIMES JAN 12.Cdr
    V E N T U R A & S A N TA B A R B A R A C O U N T Y Chrono Times Newsletter for Chapter 190 of The National Association of Watch and Clock Collectors January 2012 A Fake Elgin G. M. Wheeler spelled identically and correctly. These details are not by Dave Coatsworth typical of most Swiss fakes. Often the name or city have Take a quick look at the two watch movements been changed slightly, such as 'Waldham' instead of pictured below. A pair of Elgin G. M. Wheeler grade 'Waltham' on Waltham fakes or the name changed such as movements made in 1869 and, judging by the serial 'G. M. Weeler' instead of 'G. M. Wheeler' on Elgin fakes. numbers, probably within a few months of each other, The movements are almost exactly the same size, being right? But, wait. Take a closer look and differences can be within 0.1mm of each other in diameter. The jewel observed. Could Elgin have really made these two settings on both movements are fake. The jewel screws movements within months of each other? The answer is on the fake are larger than on the Elgin and larger than 'no.' One is a genuine Elgin G.M. Wheeler (left) and the typically seen on American movements. other is a 'Swiss Fake' (right). This one just happens to be one of the better fakes produced in Switzerland in the last third of the 19th century. It is good enough that a beginning collector may be fooled into thinking that he or she is buying a low serial number Elgin.
    [Show full text]
  • 2002 Seminaraexhibit-Landscape.Qxd
    The Exhibit Boston: Cradle of Industrial Watchmaking Table of Contents Open bookmarks for a complete listing of contents. Precursors to Industrialization . .4 by Thomas McIntyre, Ph.D. Boston Watch Company . .13 by Ron Price The BWCo. Sequel—the Model 57 . .20 by Ron Price The American Watch Company . .35 by Thomas McIntyre, Ph.D. E. Howard & Co. Related Watches & Artifacts . .75 by Clint B. Geller, Ph.D. Waltham Complicated Watches . .119 by Craig Risch and Clint B. Geller, Ph.D. Introduction to Boston: Cradle of Industrial Watchmaking By Clint B. Geller, FNAWCC, General Chairman, 2002 NAWCC Seminar America’s most important contribution to watchmaking history was published as a companion volume to the Boston seminar book.) Henry the development and first practical demonstration of truly efficient mass Fried Award recipient Philip T. Priestley then put the accomplishments production methods for watches. In order to understand this unique lega- of American watchmaking into a broader context by describing its inter- cy, it is necessary to examine why technical know-how alone failed to national impact. achieve this end in England, a preeminent contemporary watchmaking The primary focus of the seminar was the period beginning in 1857, center. It is also necessary to understand why efforts in the Boston area, with the sale of the bankrupt Boston Watch Company, and ending in beginning around 1850, finally succeeded where earlier American efforts 1875, when both the American Watch Company of Waltham and E. had failed. Howard & Company in Roxbury (now Boston), claimed succession to the A watershed event in American watch collecting, the Boston: Cradle of Boston Watch Company, and turned out watches of a wide range of vari- Industrial Watchmaking seminar, brought together a distinguished eties and grades.
    [Show full text]
  • Report Geology of Vermont
    REPORT ON THE GEOLOGY OF VERMONT: DESCRIPTIVE, THEORETICAL, ECONOMICAL, AND SCENOGRAPHICAL; BY EDWARD HITCHCOCK, LL.D., ALBERT D. HAGER, A.M., EDWARD HITCHCOCK, JR., M.D., CHARLES H. HITCHCOCK, A.M., PROFESSOR OF HYGIENE AND PHYSICAL CULTURE IN AMHERST COLLEGE. GEOLOGIST TO THE STATE OF MAINE. IN TWO VOLUMES. PUBLISHED UNDER VE AUTHORITY OF THE STATE LEGISLATURE, BY ALBERT D. HAGER, PROOTORSVILLE, VT. VOL. I. PRINTED BY THE CLAREMONT MANUFACTURING COMPANY, CLAREMONT, N. 11. 1861. NQTE. The Principal of the Survey desires to state, that the publication of this Report has been entirely under the direction of Mr. A. D. HAGER. In consequence of the great increase of the matter above the original estimate, the work has been a difficult one, and demanded not only much labor, but rigid economy, and great pecuniary responsibility and sacrifice. Yet, as the public will see, it has been carried through in excellent taste, and compares most favorably with the style of analogous Reports in other States. The citizens of Vermont are certainly much indebted to Mr. Hager for his faithful, judicious and persevering efforts - without which, these volumes never could have seen the light in a form so satisfactory. It is but justice, also, to say, that Mr. Hager was fortunate in securing the services of the Messrs. Goddard, of Claremont, for the printing. Had they not possessed unusual skill in deciphering illegible manuscripts and correcting proofs, in some cases where from distance or other causes they had not passed under the eye of the authors, errors would S have abounded where now we trust they are rare.
    [Show full text]
  • 'Kalkberg' K‐Bentonite
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Ghent University Academic Bibliography A new, high-precision CA-ID-TIMS date for the ‘Kalkberg’ K-bentonite (Judds Falls Bentonite) NEO E.B. MCADAMS , MARK D. SCHMITZ, MARK A. KLEFFNER, JACQUES VERNIERS, THIJS R.A. VANDENBROUCKE, JAMES R. EBERT AND BRADLEY D. CRAMER McAdams, N.E.B., Schmitz, M.D., Kleffner, M.A., Verniers, J., Vandenbroucke, T.R.A., Ebert, J.R. & Cramer, B.D. 2018: A new, high-precision CA-ID-TIMS date for the ‘Kalkberg’ K-bentonite (Judds Falls Bentonite). Lethaia, Vol. 51, pp. 344–356. The numerical calibration of the base of the Devonian is poorly constrained due to several factors. Few precise radioisotopic age determinations are available from the late Silurian and Early Devonian, and the limited published data carry large error bars from older analytical methodologies. Volcanic ashfalls suitable for dating occur in the Lower Devonian of the Appalachian Basin, but have not been precisely correlated into the global chronostratigraphical scheme because of limited bio- and lithostratigraphi- cal information. Here, we report a new U-Pb zircon radioisotopic age determination of 417.61 Æ 0.12(0.23)[0.50] Ma and improved chronostratigraphical context, including revised biostratigraphy, for an ash bed in the New Scotland Formation, Helderberg Group, from the Lochkovian Stage that was previously identified as the Kalkberg K-bentonite. This new information helps to integrate the classic New York Appalachian Basin succession into global Siluro-Devonian stratigraphy, refine the cali- bration of the Silurian–Devonian boundary and more precisely estimate the duration of both time periods.
    [Show full text]
  • Massachusetts
    UNITED STATES DEPARTMENT OF THE INTERIOR Ray Lyman Wilbur, Secretary GEOLOGICAL SURVEY W. C. Mendenhall, Director Bulletin 839 GEOLOGY OF THE BOSTON AREA MASSACHUSETTS BY LAURENCE LAFORGE UNITED STATES GOVERNMENT PRINTING OFFICE WASHINGTON : 1932 For_sale.jby the Superintendent of Documents, Washington; D. C. ------ Price 40 cents CONTENTS Page Introduction...___ ________________________________________________ 1 Position and general relations...-------------------------------- 1 General features of southeastern New England...___--_________-__ 1 Historical sketch.________-__--__----__----_--_-_--_-_---___'___ 4 Topography._____________-_-____--__--_____:_-_------_-___-______ 8 Features of the relief.___--_-____--_-----_-----_--_----__----__ 8 General character and divisions.____________________________ 8 Boston Lowland.___--___------------------------------_-- 9 Fells Upland.----------..__.__.___.__..-_____ 9 Needham Upland.---------------------------------------- 10 Coast line and islands.-_._--------_-------_-----_-_------- 10 Drainage features------.--.-----------------_--------_--_____. 11 Streams...---.------------------------------------------- 11 Ponds and swamps._--_--------_-__-_--_----__-__-___---__ 11 Coastal marshes_-_-__----------------------------_------- 12 Characteristics of the drainage.---------------------.------- 12 Cultural features.._.___-----__-_------------------------------ 13 Settlement-_________-_- __ ____ 13 Occupations- ._____i___-___---_- ----_----_______-___-___ 13 Communications. _ ____-__-__---_------___--_--_-_---_---__ 13 Geology_____-_-________---_-_-_---_-------_------____-_-___-__ 14 Areal geology and stratigraphy....._______--__.._._____._.______ 14 General character, age, and grouping of rocks...-_____________ 14 Pre-Cambrian rocks.--.----------------------------------- 15 General character..---__--------_----_----_-----_---__ 15 Waltham gneiss....----------------------------------- 16 Westboro quartzite..------------_-_-__-___________-__- 17 .
    [Show full text]
  • Disrupting the LINC Complex by AAV Mediated Gene Transduction Prevents Progression of Lamin Induced Cardiomyopathy
    ARTICLE https://doi.org/10.1038/s41467-021-24849-4 OPEN Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy Ruth Jinfen Chai1,7, Hendrikje Werner1,7, Peter Yiqing Li2, Yin Loon Lee 1, Khaing Thet Nyein1, Irina Solovei 3, Tuan Danh Anh Luu2, Bhavya Sharma1, Raju Navasankari1, Martina Maric1, Lois Yu En Sim 1, Ying Jie Loh1, Edita Aliwarga2, Jason Wen Long Cheong1, Alexandre Chojnowski1, Matias Ilmari Autio 4, Yu Haiyang5, Kenneth Kian Boon Tan1, Choong Tat Keng4, Shi Ling Ng2, Wei Leong Chew 4, Michael Ferenczi5, Brian Burke1, ✉ ✉ Roger Sik Yin Foo 2 & Colin L. Stewart 1,6 1234567890():,; Mutations in the LaminA gene are a common cause of monogenic dilated cardiomyopathy. Here we show that mice with a cardiomyocyte-specific Lmna deletion develop cardiac failure and die within 3–4 weeks after inducing the mutation. When the same Lmna mutations are induced in mice genetically deficient in the LINC complex protein SUN1, life is extended to more than one year. Disruption of SUN1’s function is also accomplished by transducing and expressing a dominant-negative SUN1 miniprotein in Lmna deficient cardiomyocytes, using the cardiotrophic Adeno Associated Viral Vector 9. The SUN1 miniprotein disrupts binding between the endogenous LINC complex SUN and KASH domains, displacing the cardio- myocyte KASH complexes from the nuclear periphery, resulting in at least a fivefold extension in lifespan. Cardiomyocyte-specific expression of the SUN1 miniprotein prevents cardiomyopathy progression, potentially avoiding the necessity of developing a specific therapeutic tailored to treating each different LMNA cardiomyopathy-inducing mutation of which there are more than 450.
    [Show full text]
  • 4–15–10 Vol. 75 No. 72 Thursday Apr. 15, 2010 Pages 19533–19872
    4–15–10 Thursday Vol. 75 No. 72 Apr. 15, 2010 Pages 19533–19872 VerDate Nov 24 2008 20:48 Apr 14, 2010 Jkt 220001 PO 00000 Frm 00001 Fmt 4710 Sfmt 4710 E:\FR\FM\15APWS.LOC 15APWS sroberts on DSKD5P82C1PROD with FRONTMATTER II Federal Register / Vol. 75, No. 72 / Thursday, April 15, 2010 The FEDERAL REGISTER (ISSN 0097–6326) is published daily, SUBSCRIPTIONS AND COPIES Monday through Friday, except official holidays, by the Office of the Federal Register, National Archives and Records PUBLIC Administration, Washington, DC 20408, under the Federal Register Subscriptions: Act (44 U.S.C. Ch. 15) and the regulations of the Administrative Paper or fiche 202–512–1800 Committee of the Federal Register (1 CFR Ch. I). The Assistance with public subscriptions 202–512–1806 Superintendent of Documents, U.S. Government Printing Office, Washington, DC 20402 is the exclusive distributor of the official General online information 202–512–1530; 1–888–293–6498 edition. Periodicals postage is paid at Washington, DC. Single copies/back copies: The FEDERAL REGISTER provides a uniform system for making Paper or fiche 202–512–1800 available to the public regulations and legal notices issued by Assistance with public single copies 1–866–512–1800 Federal agencies. These include Presidential proclamations and (Toll-Free) Executive Orders, Federal agency documents having general FEDERAL AGENCIES applicability and legal effect, documents required to be published by act of Congress, and other Federal agency documents of public Subscriptions: interest. Paper or fiche 202–741–6005 Documents are on file for public inspection in the Office of the Assistance with Federal agency subscriptions 202–741–6005 Federal Register the day before they are published, unless the issuing agency requests earlier filing.
    [Show full text]