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Aortic Stenosis and Mitral Regurgitation Guidelines Overview

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Aortic Stenosis and Mitral Regurgitation Guidelines Overview Rick A. Nishimura, MD, MACC, FAHA, Co-Chair† Catherine M. Otto, MD, FACC, FAHA, Co-Chair† Robert O. Bonow, MD, MACC, FAHA† Carlos E. Ruiz, MD, PhD, FACC† Blase A. Carabello, MD, FACC*† Nikolaos J. Skubas, MD, FASE¶ John P. Erwin III, MD, FACC, FAHA‡ Paul Sorajja, MD, FACC, FAHA# Robert A. Guyton, MD, FACC*§ Thoralf M. Sundt III, MD* **†† Patrick T. O’Gara, MD, FACC, FAHA† James D. Thomas, MD, FASE, FACC, FAHA‡‡ 2014 ACC/AHA Valve Guidelines Core Concepts • Valve disease stages • Improved imaging and severity quantitation • Timing of intervention aligned with disease stages • Earlier intervention with trans-catheter options • Valve Disease Centers and Heart Valve Teams • Integrative approach to procedural risk assessment 2014 ACC/AHA Valvular Heart Disease (VHD) Guidelines Definitions of Disease Severity • Patient Symptoms due to valve dysfunction • Valve Leaflet anatomy and pathology • Flow Valve hemodynamics • Ventricle Hypertrophy, dilation, dysfunction AHA/ACC Valve Guidelines Valve Disease Stages Otto and Prendergast. NEJM 2014 2014 ACC/AHA Valve Guidelines Concept of Valve Disease Stages Stage Definition Description A At risk Patients with risk factors for the development of VHD B Progressive Patients with progressive VHD (mild-to-moderate severity and asymptomatic) C Asymptomatic Asymptomatic patients who have reached the criteria severe for severe VHD C1: Asymptomatic patients with severe VHD in whom the left or right ventricle remains compensated C2: Asymptomatic patients who have severe VHD, with decompensation of the left or right ventricle D Symptomatic Patients who have developed symptoms as a result of severe VHD Why Measure Aortic Stenosis Severity ? Ensure AS is the cause of symptoms AS? Aortic Stenosis Severity Is AS severe enough to be the cause of symptoms? Vmax 4.0 cm2 1 m/s Symptoms-- 2 m/s Not due to AS 2.0 cm2 3 m/s Symptoms-- Maybe due to AS? 4 m/s 1.0 cm2 Symptoms -- 5 m/s Likely due to AS 0.5 cm2 High sensitivity valued over high specificity AVA Aortic Stenosis Severity Optimal definition of severe stenosis ? Jet velocity Vmax Pressure gradient P = 4v2 The reference standard that Valvedefines “ Areasevere” aortic stenosis Continuityis prediction of clinical equation outcome. 2014 ACC/AHA Valvular Heart Disease (VHD) Guidelines Definitions of Disease Severity 2014 ACC/AHA Valvular Heart Disease (VHD) Guidelines Definitions of Disease Severity Multivariate predictors of symptom onset (normal flow): • Aortic velocity • Not AVA 2014 ACC/AHA Valvular Heart Disease (VHD) Guidelines Aortic Stenosis Disease Stages Stage Definition Valve anatomy and hemodynamics A At risk for AS Bicuspid valve, aortic sclerosis B Progressive AS Mild AS Vmax 2.0–2.9 m/s, Mean ΔP < 20 mm Hg Mod AS Vmax 3.0–3.9 m/s, Mean ΔP 20-39 mm Hg 2 (Typically AVA >1.0 cm ) C Asymptomatic Severe AS Vmax ≥ 4.0 m/s, Mean ΔP ≥40 mm Hg severe AS (Typically AVA ≤1.0 cm2) Very severe AS Vmax ≥ 5.0 m/s, Mean ΔP ≥60 mm Hg C1: Normal LV systolic C2: LV ejection fraction < 50% D Symptomatic D1: High gradient severe AS severe AS D2: Low gradient severe AS (low EF) D3: Low-flow low-gradient severe AS (normal EF) 2014 ACC/AHA Valvular Heart Disease (VHD) Guidelines Symptomatic Severe Aortic Stenosis ECHO Vmax ≥ 4 m/s Vmax < 4 m/s AVA ≤ 1 cm2 EF < 50% D1 High Gradient 2014 ACC/AHA Valvular Heart Disease (VHD) Guidelines Symptomatic Severe Aortic Stenosis ECHO Vmax ≥ 4 m/s Vmax < 4 m/s Vmax < 4 m/s AVA ≤ 1 cm2 AVA ≤ 1 cm2 EF < 50% EF ≥ 50% Low dose DSE Calcified valve Vmax ≥ 4 m/s with Normotensive AVA ≤ 1 cm2 AVAi ≤ 0.6 cm2/m2 at any flow rate SVi < 35 ml/m2 D1 High Gradient D2 LFLG Low EF D3 LFLG Normal EF 2014 ACC/AHA Valve Guidelines TIMING of Intervention for AS Aortic valve stenosis Symptoms due to AS No AS symptoms V ≥ 4 m/s V < 4 m/s max max Vmax ≥ 5 m/s + V ≥ 4 m/s Low surgical risk max EF < 50% EF < 50% YES NO ETT with BP or 2 2 ex. capacity DSE Vmax ≥ 4 m/s AVAi 0.6 cm /m at any flow rate and SVI <35 mL/m2 Rapid disease progression + low surgical risk AVR (I) AVR (I) AVR (IIa) AVR (IIa) AVR (IIa) AVR (IIa) AVR (IIb) 2014 ACC/AHA Valve Guidelines INTERVENTION FOR AORTIC STENOSIS TIMING of Intervention CHOICE of Intervention Valve Type Surgical vs Transcatheter 2014 ACC/AHA Valve Guidelines CHOICE of Intervention for AS Indication for AVR Heart Valve Team (I) Low-intermediate High Prohibitive surgical risk surgical risk surgical risk Bridge to SAVR or TAVR for severe Predicted post-TAVR symptoms survival > 1 yr BAV (IIb) YES NO Surgical TAVR TAVR (I) Palliative AVR (I) (IIa) Care Conceptual Framework Management of Aortic Stenosis SAVR TAVR BENEFIT RISK Years of life Procedural risk Quality of life Late complications Functional status Pain/discomfort Age 50 man 90 woman Comorbidities Otherwise Frail healthy Multiple comorbidities 2014 ACC/AHA Valve Guidelines Causes of Chronic Mitral regurgitation • Primary mitral valve disease • Myxomatous (MVP) • Rheumatic • Secondary (functional) regurgitation • Ischemic • Dilated cardiomyopathy Otto CM Textbook of Clinical Echocardiography, 5th Edition, 2013. 2014 ACC/AHA Valve Guidelines Stages of Chronic Primary Mitral Regurgitation Stage Anatomy Hemodynamics Left ventricle A At risk MVP No to trace MR Normal (asymptomatic) B Progressive Severe MVP Mild to moderate Normal LV volumes (asymptomatic) Rheumatic MR: Normal LV EF Vena contracta < 0.7 cm Mild LA, Normal PAP Endocarditis ERO < 0.4 cm2, RV< 60 ml, Angio 1- 2+ C Asymptomatic Severe MVP Severe MR C1: LV EF > 60% with LV +/- flail Vena contracta ≥ 0.7 cm ESD < 40 mm Severe MR ERO ≥ 0.4 cm2, RV ≥ 60 Severe ml, Angio 3-4+ C2: LV EF ≤60% or LV ESD rheumatic ≥40 mm D Symptomatic Endocarditis Severe MR LV dilation Severe MR Radiation Vena contracta ≥ 0.7 cm Pulmonary hypertension ERO ≥ 0.4 cm2, RV ≥ 60 Moderate to severe LA ml, Angio 3-4+ 2014 ACC/AHA Valve Guidelines Valve hemodynamics with severe primary MR • Central jet MR >40% LA or holosystolic eccentric jet MR • Vena contracta ≥0.7 cm • Regurgitant volume ≥60 mL • Regurgitant fraction ≥50% • ERO ≥0.40 cm2 • Angiographic grade 3–4+ 2014 ACC/AHA Valve Guidelines LV Response to Chronic Volume Overload LV Size and Systolic Function • Echo • MRI 2014 ACC/AHA Valve Guidelines: Indications for Surgery Primary Mitral Regurgitation Severe MR Progressive MR (Stage C or D) (Stage B) Symptomatic Asymptomatic (Stage D) (Stage C) LVEF 30-60% or LVEF > 60% or New onset AF or LVEF > 30% LVESD ≥ 40 mm LVESD < 40 mm PASP > 50 mmHg (Stage C2) (Stage C1) (Stage C1) NO YES MV Surgery MV Surgery Periodic (IIb) (I) Monitoring 3D Anatomy Mitral Valve LA side LV side 3D Echo: Leaflet anatomy Prolapse Chordal rupture Amenable to: Valve repair? Systole Transcatheter procedure? Otto, Diastole Textbook of Clinical Echocardiography, 5th Ed. 2013 2014 ACC/AHA Valve Guidelines: Indications for Surgery Primary Mitral Regurgitation Severe MR Progressive MR (Stage C or D) (Stage B) Symptomatic Asymptomatic (Stage D) (Stage C) LVEF 30-60% or LVEF > 60% or New onset AF or LVEF > 30% LVESD ≥ 40 mm LVESD < 40 mm PASP > 50 mmHg (Stage C2) (Stage C1) (Stage C1) Likelihood of successful repair >95% and Expected mortality < 1% NO YES YES NO MV Surgery MV Surgery MV Repair Periodic (IIb) (I) (IIa) Monitoring Secondary Mitral Regurgitation Mechanisms and outcomes Coronary Disease • Acute ischemia • Regional LV dysfunction • Global LV dilation and dysfunction Cardiomyopathy (heart failure) • LV dilation and dysfunction • Leaflet tethering Liel-Cohen N, Guerrero JL, Otsuji Y, et al: Circulation 101[23]:2756-2763, 2000. 2014 ACC/AHA Valve Guidelines Stages of Chronic Secondary MR Stage Anatomy Hemodynamics/LV Symptoms A At risk CAD or No to trace MR--- Due to coronary (asymptomatic) Cardiomyopathy All have primary ischemia or heart failure myocardial disease B Progressive Regional LV Mild to moderate Symptoms may respond (asymptomatic) dysfx. MR: to Rx for coronary Annular dilation ERO < 0.2 cm2 ischemia or HF RV< 30 ml RF < 50% C Asymptomatic Regional or Severe MR Symptoms may respond global LV ERO ≥ 0.2 cm2 Severe MR to Rx for coronary dilation and RV ≥ 50 ml ischemia or HF dysfx. RF ≥ 50% Leaflet tethering D Symptomatic Annular dilation Severe MR HF symptoms persist 2 Severe MR ERO ≥ 0.2 cm after revascularization RV ≥ 50 ml and medical therapy RF ≥ 50% 2014 ACC/AHA Valve Guidelines Indications for Surgery Secondary Mitral Regurgitation CAD Rx HF Rx Consider CRT Symptomatic Asymptomatic Progressive Severe MR Severe MR MR (Stage D) (Stage C) (Stage B) MV Surgery Periodic Monitoring (IIb) ACC/AHA Valve Guidelines Balance between waiting and intervention Watchful Waiting Intervention Hemodynamic severity Mortality Valve anatomy Complications Progression rate Valve hemodynamics Age, comorbidities Valve durability Pt. preferences Thrombotic risk ACC/AHA Valve Guidelines Balance between waiting and intervention ACC/AHA Valve Guidelines Balance between waiting and intervention Challenges in Assessment and Management Aortic Stenosis • Diagnosis of low gradient severe AS • Intervention for asymptomatic “severe” AS • Choice of surgical vs. trans-catheter AVR • Benefit-risk balance in older adults with multiple comorbidities and frailty Challenges in Assessment and Management Mitral Regurgitation • Optimal (outcome based) definitions of MR severity • Centers of excellence for management of asymptomatic severe MR • Role of trans-catheter vs surgical approaches • Management of secondary MR .
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  • Heart Disease and Diseases of the Circulatory System in Westchester

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    Westchester County 2016.01 Department of Health KEEP HEALTHY @wchealthdept AND Community Health Assessment Data Update GET #keephealthy THE STATS Heart Disease and Diseases of the Circulatory System in Westchester In this issue: Heart disease as a Heart disease is the number one cause of death in Westchester County. leading cause of death in Westchester county In 2012, heart disease accounted for 2,113 deaths or 31% of all deaths Deaths due to heart disease across different in the county. Adding in 490 deaths due to stroke and other diseases population and risk of the circulatory system, total deaths from circulatory disease are groups 60% higher than the next leading cause of death - cancer. Hospitalizations due to cardiovascular disease- related conditions, Selected Causes of Death in Westchester County, 2012 including diseases of the heart Emergency room visits 2% 3% 7% due to cardiovascular disease-related 3% conditions Selected risk factors 4% that contribute to Heart Disease, cardiovascular disease 4% in Westchester county 31% 5% 9% Cerebrovascular Jiali Li, Ph.D. Director of Disease (Stroke), Research & Evaluation Neoplasms 5% Planning & Evaluation (Cancer), 24% Other Circulatory, Renee Recchia, MPH 3% Acting Deputy Commissioner of Administration Heart Disease Cerebrovascular Disease (Stroke) Project Staff: Other Circulatory Neoplasms (Cancer) Bonnie Lam, MPH Respiratory Diseases External Causes (e.g. accidents) Medical Data Analyst Communicable Diseases Nervous System Diseases Milagros Venuti, MPA Digestive System Diseases