The Myostatin gene: an overview of mechanisms of action and its relevance to livestock animals Article Accepted Version Aiello, D., Patel, K. and Lasagna, E. (2018) The Myostatin gene: an overview of mechanisms of action and its relevance to livestock animals. Animal Genetics, 49 (6). pp. 505-519. ISSN 1365-2052 doi: https://doi.org/10.1111/age.12696 Available at http://centaur.reading.ac.uk/77388/ It is advisable to refer to the publisher’s version if you intend to cite from the work. See Guidance on citing . To link to this article DOI: http://dx.doi.org/10.1111/age.12696 Publisher: Wiley All outputs in CentAUR are protected by Intellectual Property Rights law, including copyright law. Copyright and IPR is retained by the creators or other copyright holders. Terms and conditions for use of this material are defined in the End User Agreement . www.reading.ac.uk/centaur CentAUR Central Archive at the University of Reading Reading’s research outputs online 1 Review: The Myostatin gene: an overview of mechanisms of action and its 2 relevance to livestock animals 3 D. Aiello 1, K. Patel 2 and E. Lasagna 1 4 5 1 Dipartimento di Scienze Agrarie, Alimentari e Ambientali, Università degli Studi di 6 Perugia, Borgo XX Giugno 74, 06121, Perugia, Italy 7 2 School of Biological Sciences, University of Reading, Berkshire, RG6 6UB, United 8 Kingdom 9 10 Corresponding author: Emiliano Lasagna. Fax: +39 075 5857122. Tel: +39 075 11 5857102. E-mail address:
[email protected] 12 13 1 14 15 Summary 16 Myostatin, also known as Growth Differentiation Factor 8, a member of the 17 Transforming Growth Factor-beta (TGF-β) super-family is a negative regulator of 18 muscle development.