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Extra-Intestinal Manifestations of Inflammatory Bowel Disease
Open Access Review Article DOI: 10.7759/cureus.17187 Extra-Intestinal Manifestations of Inflammatory Bowel Disease Aliya H. Sange 1 , Natasha Srinivas 2 , Mubashira K. Sarnaik 3 , Srimy Modi 1 , Yasaswi Pisipati 4 , Sarayoo Vaidya 3 , Naqvi Syed Gaggatur 3 , Ibrahim Sange 5, 6 1. Research, K.J. Somaiya Medical College, Mumbai, IND 2. Research, BGS Global Institute of Medical Sciences, Bangalore, IND 3. Internal Medicine, M.S. Ramaiah Medical College, Bangalore, IND 4. Psychiatry, M.S. Ramaiah Medical College, Bangalore, IND 5. Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA 6. Medicine, K.J. Somaiya Medical College, Mumbai, IND Corresponding author: Aliya H. Sange, [email protected] Abstract Inflammatory bowel disease (IBD) is associated with extra-intestinal manifestations (EIMs) that tend to parallel intestinal activity and have a debilitating effect on the quality of life. EIMs primarily affect the joints, skin, and eyes with less frequent involvement of the liver, kidney, and pancreas. This article reviews the prevalence of musculoskeletal, dermatological, ocular, and other manifestations in IBD and their coalition with underlying intestinal inflammation. EIMs occurring independently of intestinal activity are managed by targeted therapies, categorical regimens, and specific treatments. On the other hand, EIMs paralleling the bowel activity are carefully monitored while the IBD is brought under control. Since the etiology of the disease is responsible for the development of the EIMs, the research scrutinizes the identified pathogenic mechanisms that tend to involve genetic susceptibility, aberrant self-recognition, and autoantibodies directed against organ-specific antigens shared by intestinal and extra-intestinal organs. This article also provides an overview of the epidemiology, clinical features, diagnostic modalities, and management of the EIMs associated with IBD. -
History Lectured on Midwifery at St Bartholomew’S Hospital and and Was in Attendance at the Births of All of Her Children
J R Coll Physicians Edinb 2012; 42:274–9 Paper http://dx.doi.org/10.4997/JRCPE.2012.317 © 2012 Royal College of Physicians of Edinburgh Sir Charles Locock and potassium bromide MJ Eadie Honorary Research Consultant and Emeritus Professor, Faculty of Health Sciences, University of Queensland, Royal Brisbane and Women’s Hospital, Australia ABSTRACT On 12 May 1857, Edward Sieveking read a paper on epilepsy to the Correspondence to M Eadie Royal Medical and Chirurgical Society in London. During the discussion that Faculty of Health Sciences, followed Sir Charles Locock, obstetrician to Queen Victoria, was reported to have University of Queensland, Royal Brisbane and Women’s commented that during the past 14 months he had used potassium bromide to Hospital, Herston, successfully stop epileptic seizures in all but one of 14 or 15 women with ‘hysterical’ Brisbane 4029, Australia or catamenial epilepsy. This report of Locock’s comment has generally given him credit for introducing the first reasonably effective antiepileptic drug into medical Tel 61 2 (0)7 38311704 e-mail [email protected] practice. However examination of the original reports raises questions as to how soundly based the accounts of Locock’s comments were. Subsequently, others using the drug to treat epilepsy failed to obtain the degree of benefit that the reports of Locock’s comments would have led them to expect. The drug might not have come into more widespread use as a result, had not Samuel Wilks provided good, independent evidence for the drug’s antiepileptic efficacy in 1861. KEYWORDS Epilepsy treatment, Charles Locock, potassium bromide, Edward Sieveking, Samuel Wilks DECLaratIONS OF INTERESTS No conflicts of interest declared. -
Editorial Ulcerative Colitis: the Scope of the Scopes in Nomenclature and Diagnosis
Tropical Gastroenterology 2011;32(2):87–93 Editorial Ulcerative Colitis: The scope of the scopes in nomenclature and diagnosis S. Datta Gupta Department of Pathology Life-long learning is the hall-mark of professional education. This is often the result of All India Institute of Medical Sciences experiences shared by our colleagues world-wide, of common clinical conditions that present New Delhi - 110029, India in an unusual manner. Correspondence: The two major constituents of inflammatory bowel disease: Crohn’s disease (CD) and Dr. S. Datta Gupta ulcerative colitis (UC) have several overlapping features and their distinction in difficult Email: [email protected] cases is a true accreditation of the skills of a gastroenterologist. Indistinguishable cases are aptly labeled as indeterminate colitis. In certain countries such as India, additionally, colonic tuberculosis (TB) is a close differential of colonic Crohn’s disease mainly because both are recognized to show patchy involvement and granulomatous inflammation. In this issue of the journal, Shah SN, Amarapurkar AD, Thiruvengadam NR, Nistala S and Rathi PM1 highlight unusual presentations of ulcerative colitis that may make the diagnosis otherwise difficult. Non-contagious diarrheal diseases have been apparent to physicians over centuries having been described by Aretaeus (A.D. 300) and Soranus (A.D. 117).2 Sir Samuel Wilks in 18593 has been credited with introducing the term “ulcerative colitis” to a disease that was less understood then and perhaps even lesser understood today. It is likely that several clinically similar diseases may have been considered under this term. Thus it has been suggested that in 1745 Prince Charles, the Young Pretender to the throne, cured himself of ulcerative colitis by adopting a milk-free diet!2,4 Excellent descriptions have been provided by the Surgeon General of the Union Army (describing the medical history of the American Civil War), Wilks & Moxon (1875), Allchin (1885) and Hale-White (1888). -
Slater V. Baker and Stapleton (C.B. 1767): Unpublished Monographs by Robert D. Miller
SLATER V. BAKER AND STAPLETON (C.B. 1767): UNPUBLISHED MONOGRAPHS BY ROBERT D. MILLER ROBERT D. MILLER, J.D., M.S. HYG. HONORARY FELLOW MEDICAL HISTORY AND BIOETHICS DEPARTMENT SCHOOL OF MEDICINE AND PUBLIC HEALTH UNIVERSITY OF WISCONSIN - MADISON PRINTED BY AUTHOR MADISON, WISCONSIN 2019 © ROBERT DESLE MILLER 2019 BOUND BY GRIMM BOOK BINDERY, MONONA, WI AUTHOR’S INTRODUCTION These unpublished monographs are being deposited in several libraries. They have their roots in my experience as a law student. I have been interested in the case of Slater v. Baker and Stapleton since I first learned of it in law school. I was privileged to be a member of the Yale School Class of 1974. I took an elective course with Dr. Jay Katz on the protection of human subjects and then served as a research assistant to Dr. Katz in the summers of 1973 and 1974. Dr. Katz’s course used his new book EXPERIMENTATION WITH HUMAN BEINGS (New York: Russell Sage Foundation 1972). On pages 526-527, there are excerpts from Slater v. Baker. I sought out and read Slater v. Baker. It seemed that there must be an interesting backstory to the case, but it was not accessible at that time. I then practiced health law for nearly forty years, representing hospitals and doctors, and writing six editions of a textbook on hospital law. I applied my interest in experimentation with human beings by serving on various Institutional Review Boards (IRBs) during that period. IRBs are federally required committees that review and approve experiments with humans at hospitals, universities and other institutions. -
A Catalogue of the Fellows, Candidates, Licentiates [And Extra
MDCCCXXXVI. / Od- CATALOGUE OF THE FELLOWS, CANDIDATES, AND LICENTIATES, OF THE ftogal College of LONDON. STREET. PRINTED 1!Y G. WGOUFAM., ANGEL COURT, SKINNER A CATALOGUE OF THE FELLOWS, CANDIDATES, AND LICENTIATES, OF THE Ittojjal College of ^ijpstrtans, LONDON. FELLOWS. Sir Henry Halford, Bart., M.D., G.C.IL, President, Physician to their Majesties , Curzon-street . Devereux Mytton, M.D., Garth . John Latham, M.D., Bradwall-hall, Cheshire. Edward Roberts, M.D. George Paulet Morris, M.D., Prince s-court, St. James s-park. William Heberden, M.D., Elect, Pall Mall. Algernon Frampton, M.D., Elect, New Broad- street. Devey Fearon, M.D. Samuel Holland, M.D. James Franck, M.D., Bertford-street. Park- lane. Sir George Smith Gibbes, Knt., M.D. William Lambe, M.D., Elect, Kings-road, Bedford-row. John Johnstone, M.D., Birmingham. Sir James Fellowes, Knt., M.D., Brighton. Charles Price, M.D., Brighton. a 2 . 4 Thomas Turner, M.D., Elect, and Trea- Extraordinary to surer, Physician the Queen , Curzon-street Edward Nathaniel Bancroft, M.D., Jamaica. Charles Dalston Nevinson, M.D., Montagu- square. Robert Bree, M.D., Elect, Park-square , Regent’s-park. John Cooke, M.D., Gower-street Sir Arthur Brooke Faulkner, Knt., M.D., Cheltenham. Thomas Hume, M.D., Elect, South-street , Grosvenor-square. Peter Rainier, M.D., Albany. Tristram Whitter, M.D. Clement Hue, M.D., Elect, Guildford- street. John Bright, M.D., Manchester-square. James Cholmeley, M.D., Bridge-street Henry , Blackfriars. Sir Thomas Charles Morgan, Knt., M.D., Dublin. Richard Simmons, M.D. Joseph Ager, M.D., Great Portland-st. -
The Contribution of T Cell-Derived Cytokines and Proteases to Chronic Inflammation in the Human Intestine
The contribution of T cell-derived cytokines and proteases to chronic inflammation in the human intestine by Paolo Biancheri A thesis submitted for the Degree of Doctor of Philosophy Supervisor: Prof Thomas T MacDonald Second supervisor: Prof Andrew Silver Queen Mary University of London Barts and The London School of Medicine and Dentistry London - United Kingdom 2016 This work is dedicated to the memory of my grandparents Margherita, Luigi, Bianca, and Paolo 2 Statement of originality I, Paolo Biancheri, confirm that the research included within this thesis is my own work or that, where it has been carried out in collaboration with, or supported by others, this is duly acknowledged below and my contribution indicated. Previously published material is also acknowledged below. I attest that I have exercised reasonable care to ensure that the work is original, and does not to the best of my knowledge break any UK law, infringe any third party’s copyright or other Intellectual Property Right, or contain any confidential material. I accept that the College has the right to use plagiarism detection software to check the electronic version of the thesis. I confirm that this thesis has not been previously submitted for the award of a degree by this or any other university. The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the author. Signature: Date: 28.02.2016 Details of collaboration I declare that the work presented in this thesis is my own, with the exception of some of the experiments reported in Chapters 3, 4 and 6, which, upon obtaining approval from the owners of the data, have been included in this thesis and have been listed in the Note at the beginning of the Chapters. -
Medico-Chirurgical Transactions
MEDICO-CHIRURGICAL TRANSACTIONS. PUBLISHED BY THE ROYAL MEDICAL AND CHIIRURGICAL SOCIETY OF LONDON. VOLUME THE SIXTY-THIRD. LONDON: LONGMANS, GREEN, READER, AND DYER, PATERNOSTER ROW. 1880. i........OO.EOHTR:IJRQIOA .'.TRANSACTIONS.- THE ROYAL MEDICAL AND. CIUURGICAL SOCIETY * ~~~or LONDON. SECOND SERIES. VOLUME THE FORTY-PffmT LONDON: LONGMANS, G[REN, READER, AND DYER, PATERNOSTER ROW. 1880. PRINTED BY J. E. ADLARD, BARTHOLOXEW COSE. ROYAL MEDICAL AND CHIRURGICAL SOCIETY OF LONDON. PATRON. THE QUEEN. OFFICERS AND COUNCIL, ELECTED MARCH 1, 1880. 8resihet,t JOHN ERIC ERICHSEN, F.R.S. rCHARLES BLAND RADCLIFFE, M.D. ALFRED BARING GARROD, M.D., F.R.S. VICE-PRESIDENTS. BARNARD WIGHT HOLT. LJOHN BIRKETT. r WILLIAM WEGG, M.D. TREASURERS. l JOHN COOPER FORSTER. { REGINALD EDWARD THOMPSON, M.D. SECRETARIES. TIMOTHY HOLMES. GEORGE JOHNSON, M.D., F.R.S. LIBRARIANS. L l JOHN WHITAKER HULKE, F.R.S. r JOHN LANGDON H. DOWN, M.D. CHARLES HILTON FAGGE, M.D. SAMUEL FENVICK, M.D. JOHN HARLEY, M.D. OTHER MEMBERS J GEORGE ROPER, M.D. OF COUNCIL. ] FREDERICK JAMES GANT. CHRISTOPHER HEATH. FRANCIS MASON. JOHN MORGAN. ALFRED WILLETT. THE ABOVE FORM THE COUNCIL. RESIDENT ASSISTANT-LIBRARIAN. BENJAMIN ROBERT WHEATLEY. A LIST OF THE PRESIDENTS OF THE SOCIETY FROM ITS FORMATION. ELECTED 1805. WILLIAM SAUNDERS, M.D. 1808. MATTHEW BAILLIE, M.D. 1810. SIR HENRY HALFORD, BART., M.D., G.C.H. 1813. SIR GILBERT BLANE, BART., M.D. 1815. HENRY CLINE. 1817. WILLIAM BABINGTON, M.D. 1819. SIR ASTLEY PASTON COOPER, BART., K.C.H., D.C.L. 1821. JOHN COOKE, M.D. 1823. JOHN ABERNETHY. 1825. -
New Inventions. Ordinary ; Sir James Clark, Physician to the Queen and to the Queen’S Household (Licentiate); and Dr
639 Cranial Nerves. This article, though short, is a valuable and the fluid from the cyst should at once begin to run ; if it does not the rubber air-ball should be one and represents an amazing amount of careful work. compressed, when the contents of the if fluid or The above-named nerves were dissected out along their whole cyst, gelatinous, should certainly find exit. The makers are Messrs. Arnold course and after being hardened were sectioned along their and Sons of Smithfield, London, E.C. entire length. 8. By Dr. Walter H. Gaskell, F.R.S.: On the Cheltenham. ALEXANDER DUKE. Origin of Vertebrates deduced from the Study of Ammo- coetes. This article constitutes the ninth part of a long argument on a theory advanced by Dr. Gaskell in regard to AN LIST. the phylogeny of the Vertebrata contained in previous INTERESTING numbers of the Journal and is occupied with a discussion on the probable mode of origin of the vertebrate eye. 9. THE following is a list of the Fellows of the Royal College The last article contains the proceedings of the Anatomical of Physicians of London and a few (old) Licentiates or Society of Great Britain and Ireland. Members who held appointments to Her late Majesty Quem Victoria as physicians :- 1837.-Sir Henry Halford, Bart., physician to the Queen ; Sir James M’Grigor, Bart., Sir Henry Holland, Bart., and Dr. Richard Bright, physicians extra- New Inventions. ordinary ; Sir James Clark, physician to the Queen and to the Queen’s household (Licentiate); and Dr. Neil Arnott, physician extraordinary A SYRINGE FOR THE NOSE AND EAR. -
Smythe-Wood Series B
Mainly Ulster families – “B” series – Smythe-Wood Newspaper Index Irish Genealogical Research Society Dr P Smythe-Wood’s Irish Newspaper Index Selected families, mainly from Ulster ‘SERIES B’ The late Dr Patrick Smythe-Wood presented a large collection of card indexes to the IGRS Library, reflecting his various interests, - the Irish in Canada, Ulster families, various professions etc. These include abstracts from various Irish Newspapers, including the Belfast Newsletter, which are printed below. Abstracts are included for all papers up to 1864, but excluding any entries in the Belfast Newsletter prior to 1801, as they are fully available online. Dr Smythe-Wood often found entries in several newspapers for the one event, & these will be shown as one entry below. Entries dealing with RIC Officers, Customs & Excise Officers, Coastguards, Prison Officers, & Irish families in Canada will be dealt with in separate files. In most cases, Dr Smythe-Wood has recorded the exact entry, but in some, marked thus *, the entries were adjusted into a database, so should be treated with more caution. There are further large card indexes of Miscellaneous notes on families which are not at present being digitised, but which often deal with the same families treated below. ACR: Acadian Recorder LON The London Magazine ANC: Anglo-Celt LSL Londonderry Sentinel ARG Armagh Guardian LST Londonderry Standard BAA Ballina Advertiser LUR Lurgan Times BAI Ballina Impartial MAC Mayo Constitution BAU Banner of Ulster NAT The Nation BCC Belfast Commercial Chronicle NCT -
A History of English Literature MICHAEL ALEXANDER
A History of English Literature MICHAEL ALEXANDER [p. iv] © Michael Alexander 2000 All rights reserved. No reproduction, copy or transmission of this publication may be made without written permission. No paragraph of this publication may be reproduced, copied or transmitted save with written permission or in accordance with the provisions of the Copyright, Designs and Patents Act 1988, or under the terms of any licence permitting limited copying issued by the Copyright Licensing Agency, 90 Tottenham Court Road, London W 1 P 0LP. Any person who does any unauthorised act in relation to this publication may be liable to criminal prosecution and civil claims for damages. The author has asserted his right to be identified as the author of this work in accordance with the Copyright, Designs and Patents Act 1988. First published 2000 by MACMILLAN PRESS LTD Houndmills, Basingstoke, Hampshire RG21 6XS and London Companies and representatives throughout the world ISBN 0-333-91397-3 hardcover ISBN 0-333-67226-7 paperback A catalogue record for this book is available from the British Library. This book is printed on paper suitable for recycling and made from fully managed and sustained forest sources. 10 9 8 7 6 5 4 3 2 1 09 08 07 06 05 04 03 02 O1 00 Typeset by Footnote Graphics, Warminster, Wilts Printed in Great Britain by Antony Rowe Ltd, Chippenham, Wilts [p. v] Contents Acknowledgements The harvest of literacy Preface Further reading Abbreviations 2 Middle English Literature: 1066-1500 Introduction The new writing Literary history Handwriting -
The Hospital Ward: Legitimizing Homœopathic Medicine Through the Establishment of Hospitals in !"Th-Century London and Madrid
“Globulizing” the Hospital Ward: Legitimizing Homœopathic Medicine through the Establishment of Hospitals in !"th-Century London and Madrid Felix Stefan von Reiswitz Submitted in fulfillment of the requirements for the degree of PhD History of Medicine. UCL, Department of History Submitted November 2012 Declaration Declaration of Originality Declaration I, Felix Stefan von Reiswitz, declare that the work submitted is my own and that appropriate credit has been given where reference has been made to the work of others. F. S. von Reiswitz London, November 2012 2 Acknowledgements Acknowledgements Acknowledgements I would like to thank my supervisors, present and past, Dr. rer. nat. Helga Satzinger, Prof. Anne Hardy and Dr. Michael Neve for their tireless and patient guidance throughout this thesis’s long gestation. This thesis benefitted substantially from a “Marie Curie Fellowship for Early Stage Training” held at the Universidad Pablo de Olavide (Seville) and a completion grant from the Institut für Geschichte der Medizin der Robert Bosch Stiftung as well as from a travel grant from the Wellcome Trust Centre for the History of Medicine at UCL. My thanks also go to all those who generously gave their valuable time and knowledge to comment, advise and guide through the different stages of this project, especially Prof. Martin Dinges, Dr. Andrew Wear, Prof. Manuel Herrero Sánchez and Mr. Félix Antón Cortés who opened many doors and guided me through the maze of both Spanish bureaucracy and nineteenth-century Madrid. I am deeply indebted to all those who facilitated my access to public and private collections. Mrs. Enid Segall; Ms. Sato Liu; Mr. -
Tennyson's Poems
Tennyson’s Poems New Textual Parallels R. H. WINNICK To access digital resources including: blog posts videos online appendices and to purchase copies of this book in: hardback paperback ebook editions Go to: https://www.openbookpublishers.com/product/944 Open Book Publishers is a non-profit independent initiative. We rely on sales and donations to continue publishing high-quality academic works. TENNYSON’S POEMS: NEW TEXTUAL PARALLELS Tennyson’s Poems: New Textual Parallels R. H. Winnick https://www.openbookpublishers.com Copyright © 2019 by R. H. Winnick This work is licensed under a Creative Commons Attribution 4.0 International license (CC BY 4.0). This license allows you to share, copy, distribute and transmit the work; to adapt the work and to make commercial use of the work provided that attribution is made to the author (but not in any way which suggests that the author endorses you or your use of the work). Attribution should include the following information: R. H. Winnick, Tennyson’s Poems: New Textual Parallels. Cambridge, UK: Open Book Publishers, 2019. https://doi.org/10.11647/OBP.0161 In order to access detailed and updated information on the license, please visit https://www.openbookpublishers.com/product/944#copyright Further details about CC BY licenses are available at http://creativecommons.org/licenses/by/4.0/ Digital material and resources associated with this volume are available at https://www.openbookpublishers.com/product/944#resources Every effort has been made to identify and contact copyright holders and any omission or error will be corrected if notification is made to the publisher.