Diabetes Research Institute Foundation Summer 2008 / Volume 36 / Issue 1 Miami / New York / Long Island / California / Washington, D.C. DRIfocus DRI DISCOVERS IMPORTANT REGULATOR OF BLOOD SUGAR Researchers from the Diabetes Research Institute’s Islet Physiology Laboratory and the Karolinska Institutet in Stockholm, Sweden, have identified an important mechanism that helps the body maintain normal blood sugar levels. The novel study was important enough to be featured on the cover of the June 2008 issue of the prestigious journal Cell Metabolism .

The regulation of normal blood glucose levels relies primarily on the function of two types of cells that are found inside the islets in the pancreas – beta cells which produce insulin, and alpha cells which produce glucagon. These cells work together to maintain a delicate balance for normal blood sugar levels and prevent both hyperglycemia (high blood sugar levels) and hypoglycemia (low blood sugar levels). Alpha cells release glucagon when there is an increase in insulin production and/or a drop in blood sugar levels. In individuals with type 1 diabetes, this mechanism is impaired or lost altogether. The research team, led by Drs. Per-Olof Berggren , Alejandro Caicedo and Over Cabrera , found that, in addition to glucagon, pancreatic alpha cells also release gluta mate, a

> Continues on Page 6 Fluorescent markers identify specific cell types within the same islet. Image D combines the insulin, glucagon and glutamate-containing cells involved in the complex DRI FOUNDATION SURPASSES FIVE-YEAR regulation of normal blood sugar levels. GOAL TO RAISE $100 MILLION “…The DRI Foundation now ranks among the leading diabetes fundraising organizations in this country and internationally …yet we remain unique in the world of diabetes.”

> See Chairman’s Message on Page 2

Dare to Dream A Silver Anniversary Armani Exchange Supermodel DRI Golf Classic in CA Tackling Diabetes

Recently retired NY Giants Former Dolphins quarter - Supermodel Izabel Goulart Sports Journalist Roy New England Patriots defensive end Michael backs Don Strock and proved that“Giving Never Firestone and Baseball nose tackle Vince Wilfork Strahan included himself celebrated Goes Out of Style” through Great Don Baylor played hosted his fifth Draft Day in the golf foursome the 25th annual Don her support of the DRI at integral roles in the DRI fundraiser benefiting that he auctioned off at Strock Diabetes Classic. the Armani Exchange store Golf Classic in California. the DRI. D.R.E.a.M.S. in the City. in NYC's Soho.

> Articles on Pages 16 > Article on Page 13 > Article on Page 12 > Article on Page 17 > Article on Page 13 A Message from the Chairman Dear Friends, The close of the Diabetes Research Institute Foundation’s 2007/08 Clearly the work of the DRI and Foundation is attracting the attention fiscal year on June 30th marked the end of our five-year plan to raise of those who seek accountability, transparency and a focused mission $100 million for the Diabetes Research Institute. We are extremely when supporting a diabetes organization. For each of the past two pleased to announce that not only have we achieved our goal, but years, the DRI Foundation has earned a four-star rating, the highest have surpassed it by 25 percent, raising more than $125 million over possible, from Charity Navigator, the nation’s largest independent the last five years! evaluator of charities. Only 15 percent of all charities evaluated have received back-to-back four-star ratings, indicating that “the Diabetes This is an extraordinary accomplishment and one that could not Research Institute Foundation outperforms most charities in America have been realized without the unwavering generosity of our donors. in its efforts to operate in the most fiscally responsible way possible.” The DRI Foundation now ranks among the leading diabetes fundraising organizations in this country and internationally. Yet with our singular Each and every donor can feel confident that their contributions focus on curing those living with this disease, we remain unique in were stewarded in the most responsible and efficient manner. Your the world of diabetes. critical support of the Foundation has enabled the DRI to pursue the newest directions in science, merging traditional research approaches What is perhaps most notable is that almost 40 percent of the funds with cutting-edge, emerging technologies. Armed with these powerful raised during this campaign, across all donation levels, came from tools, DRI scientists are re-engineering the path to a cure for those contributors who had never before given to our organization, including living with diabetes. many of you reading this issue of DRIfocus. We invite you to learn more about these promising research develop - The importance of planned gifts cannot be overstated as the DRIF ments, some of which are covered in this issue. As we embark on a was the beneficiary of a number of bequests throughout these past new year and a new plan, we will be sharing some exciting information few years. The legacy created by these generous individuals will help with you in the months to come. You have played an integral role in to transform the futures of those living with this disease. the DRI’s tremendous progress and we hope to count on your contin - The significant involvement of our lay leadership also contributed uing support. We are all working together for a common goal and immensely to the success of our campaign. Many new members each of you is needed now more than ever before. Thank you again have joined our National and Regional Boards of Directors, which for your generosity and commitment to this organization. are comprised of dedicated individuals from around the United Sincerely, States and as far away as Italy and England. Our leadership’s per - sonal connection to diabetes and passionate resolve to find a cure drives them to support the DRI and to engage others within their own communities who share our mission. Thomas D. Stern Chairman of the Board

ANTHONY E. CHILDS SELECTED TO LEAD FOUNDATION’S LONG ISLAND OFFICE

As the DRI continues its life-saving work toward a cure for diabetes, it is more critical than ever for the Foundation to raise the increased funds necessary to support its many cutting-edge initiatives. Efforts in Long Island have been key to the Foundation’s overall success. In order to fulfill its financial obligation to support the DRI, the Foundation must continue to grow and attract new donors. To help spearhead additional fund-raising opportunities, Anthony E. Childs has been appointed Long Island regional director. “I am excited to be involved with an organization that is so focused on finding a cure for diabetes,” said Tony. “On my visit to the Diabetes Research Institute, I was inspired by the drive and the commitment of the scientists working there. I have taken it on as a personal mission to ensure that these researchers have the funds they need to continue their important work.” Tony joins the organization after a long and established tenure in the nonprofit arena, where he held senior development and marketing positions with human services and healthcare organizations. He has worked closely with several boards of directors and various committees to achieve results at the American Cancer Society as director of major gifts, St. Catherine of Siena Medical Center in Smithtown as vice president of development, and the Interfaith Nutrition Network as director of development. Tony holds a master’s degree in nonprofit management and is an active member of the Association of Fundraising Professionals. Additionally, he has gained nearly a decade of experience in the insurance/financial services industry. “We have experienced overwhelming growth over the last several years, and it became necessary for the Foundation to add senior level leadership so that we can continue our momentum. Tony brings tremendous strength to this organization, and we are thrilled to have him join us,” said DRI Foundation President and CEO Robert A. Pearlman . Pictured left to right: Mark H. Ayers , William Fishlinger , Glenn Kleiman , Alan S. Kava , Steven NEW DIRECTORS JOIN NATIONAL, Silva and Bruce Waller. REGIONAL BOARDS

The Diabetes Research Institute Foundation is pleased to announce the appointment of three new members to the National Board and three new members to the regional boards.

National Board member Mark H. Ayers of Baltimore, MD, is the His mother, Marge Kleiman Mintz , continues to serve on the Florida president of the Building and Construction Trades Department of Regional Board. His brother, Gary , and his daughter, Alison , 23, have the AFL-CIO. Prior to his unanimous election on September 6, 2007 type 1 diabetes. He and his wife, Gisela Terner , also have another as president of the BCTD, Mark was the director of the Construction daughter, Marley, 16. Maintenance Department of the International Brotherhood of Northeast Board member Alan S. Kava of New York City is the chief Electrical Workers (IBEW) and chair of the National Maintenance financial officer of the Whitehall Street Real Estate Funds, a division Agreements Policy Committee (NMAPC). He has held other positions of Goldman Sachs. He joined Goldman Sachs as a vice president in within the IBEW and attended the George Meany Institute for Labor 1997 and became a managing director in 2002. Prior to joining the Studies (now known as the National Labor College), the University of firm, he worked as an associate attorney in the Corporate and Real Wisconsin, the University of Illinois Institute of Labor and Industrial Estate Departments of Simpson, Thacher & Bartlett. Alan earned a Relations, and the International Foundation for Employee Benefits. BA in economics from the University of Virginia in 1987 and a JD He also served his country as an aviator in the United States Navy. from New York University’s School of Law in 1990. He and his wife, The men and women of the BCTD are the Foundation’s largest Lisa , have two children, Ben , 9, who has type 1 diabetes, and Zoe , 6. contributors. The partnership reached a milestone when the unions funded and built the Diabetes Research Institute facility Northeast Board member Steven Silva of Long Island, NY, is the in Miami, and they continue to raise millions of dollars for the DRI president and chief operating officer of Chem Rx, a major, long-term each year through their Dollars Against Diabetes (DAD’s Day) care pharmacy. He is responsible for overseeing the operations and and other campaigns. workflow at Chem Rx’s five sites, with continued focus in sales, mar - keting and client services. During his 16-year tenure, he has held National Board member William Fishlinger of Plandome, NY, is several positions within the company, including director of corporate chairman and chief executive officer of Wright Risk Management operations and vice president of sales and servicing. A graduate of and is also the senior partner and president of the law firm of New York University, Steven is involved with a number of charitable Congdon, Flaherty, O'Callaghan, Reid, Donlon, Travis & Fishlinger. Bill organizations and also offers guidance to over a dozen healthcare- has been recognized for the creation of some of the most innovative related non-profit organization committees. Steven’s mother battled and successful risk financing vehicles, including NYMIR and NYSIR, type 1 diabetes for much of her life, and he is determined to help and has lectured extensively in the areas of general litigation, envi - find a cure. He and his wife, Shanna , have three children, twins ronmental law, medical malpractice, risk management and insurance. Robert and Brandon , 7, and Alex , 3. A graduate of St. John's University School of Law and the State University of Maryland, he is admitted to practice law in both the Long Island Board member Bruce Waller of Upper Brookville, NY, is Federal and State courts of New York. He also served in the United the president of Gold Coast Properties and Development, LTD. and States Air Force. He and his wife, Joan , established the Future of GW Development, LLC. He is involved in private real estate develop - Leadership Foundation, whose mission is to control, prevent and ment, operation and management and is also a New York State cure juvenile diabetes and other conditions that threaten the future licensed real estate broker. Prior to this, he served as an executive of young people. Both Bill and Joan are active members of the Long of a large private manufacturing and import/export conglomerate Island Regional Board’s Executive Committee. Their tireless efforts and as president of Décor, Inc. Bruce is also a member of the board of are in honor of their daughter, Alex , who has type 1 diabetes. They directors at Congregation Teferith Israel. He and his wife, Long Island also have a son, Matt . Board member Roberta Waller , have been dedicated supporters of the DRI ever since their daughter, Dara , was diagnosed with type 1. National Board member Glenn Kleiman of Fox Point, WI, is president They also have two sons, Andrew and Skylor . and owner of Fullhouse, an interactive marketing agency in Milwauke e and Chicago. Fullhouse provides services—such as website develop - At the National Board’s May meeting, the 39-member group also ment and interactive games—for leading business-to-consumer and paid tribute to outgoing directors Samuel J. Fox , Eugene Milgram , business-to-business brands. Born in Miami Beach, FL, Glenn attended Marge Kleiman Mintz and Edward James Olmos . These individuals Northwestern University, where he received a bachelor’s degree from will now serve on the Honorary Board. the Medill School of Journalism. He began his professional career as a television news reporter and manager, winning four Emmy Awards and a Peabody. He founded Fullhouse in 1989. His parents have been supporters of the DRI Foundation since its earliest beginnings. Glenn's late father, Marty , served as chairman of the National Board.

3| 1 2 1. Sue (2nd from left) and Norman Kenyon with their daughters, Pam Kenyon (far left), Dr. Norma Sue Kenyon (2nd from right) and Cyndi Drake (far right).

2. The Kenyon family will stop at nothing until they find a cure for Laura Mauriello .

THE KENYON FAMILY'S MISSION

Medicine practically runs in the Kenyon family’s blood. Patriarch Dr. Norman Kenyon is a retired surgeon who volunteers his services in the labs at the Diabetes Research Institute. Past chief of staff at both Baptist Hospital and Doctors Hospital in South Florida, he continues to serve as trustee of Baptist Health and chairman of the board at Doctors Hospital. His wife, Sue , is a registered nurse, and their three daughters all work in the medical field – possibly the most recognized being the DRI's Dr. Norma Sue Kenyon . But it’s the third generation that drives their passionate commitment to find a cure for diabetes. Sixteen-year-old Laura Mauriello , Sue and Norman's granddaughter and Norma’s daughter, was diagnosed as an infant, and the family will stop at nothing until a cure is found. For Norman, working in the DRI labs side-by-side with his daughter, and serving on the Foundation’s Florida board, simply weren’t enough. He wanted to do more. As a retiree living on a fixed income, he determined that the best way to maximize a financial gift was through life insurance. Together, he and Sue made the DRI Foundation the beneficiary of their life insurance policy which provided them with an immediate tax deduction for the lesser of the policy’s fair market value or the net premiums paid. In order to build value in the policy, the Kenyons continue to make contributions to cover the cost of subsequent premiums. This provides them with an annual deduction as well. “I’m very tied in to fundraising, and it was clear to me that life insurance was the best option for us,” said Norman. “My connection to the cause couldn’t be more personal, having a granddaughter with diabetes and a daughter who is working to come up with a way to correct, cure or eliminate diabetes. “I’m also very proud that I can continue to teach, train and test different techniques at the DRI. There are so many complexities to achieving our goal; the only way to do it is by working methodically and persistently,” he concluded. With Norman and Sue’s gift, their names join dozens of others on a commemorative wall at the Diabetes Research Institute as members of the DRI Heritage Society. There are a number of ways that insurance can be used to support the DRI. By naming the DRI Foundation as the beneficiary of your life insurance policy, you can turn a relatively modest annual outlay for the premium into a much larger gift, and you will receive an estate tax deduction for the insurance proceeds. To learn more about utilizing life insurance to make a charitable gift, please contact the DRI Foundation office at 800-321-3437 or [email protected].

DRIF’s Jeffrey Young JOINS FICPA BOARD OF GOVERNORS

Individuals who ensure the future of the DRI through generous provisions made in their estate plans via wills, life insurance, charitable remainder trusts, charitable gift annuities and Jeffrey Young , chief financial officer of the Diabetes Research Institute other planned giving vehicles are recognized as part of the Foundation, has been elected to the Board of Governors of the DRI Heritage Society. Florida Institute of Certified Public Accountants (FICPA). Jeff will represent the DRIF and other not-for-profit organizations based Members are included on a designated wall of honor at the DRI. in the state of Florida. They receive a special award, are invited to attend one of the DRI Foundation’s annual donor appreciation dinners, and are listed “It is an honor to be recognized by your peers and to serve on the in the DRI Annual Report and several other publications. board,” said Jeff, who chaired the FICPA’s Not-for-Profit Organization Conference held in Ft. Lauderdale and Tampa last year. Jeff has If you have made provisions for the DRI or are planning to do so, worked for the DRIF for the past 14 years after spending the earlier we would like to include you in this special group of supporters. part of his career in public accounting and industry. By becoming part of the Heritage Society, you are providing us with the opportunity to express our gratitude while inspiring Tallahassee-based FICPA was founded in 1905. It is a professional others to support the DRI through their estate plans as well. association representing more than 19,000 member CPAs Please call 800-321-3437 to learn more. throughout Florida FROM ONE GENERATION TO THE NEXT

“Dad, don’t worry. God wanted me to be just like you.” Most parents would be thrilled to hear such meaningful words spoken by a child. But for John Reisman , his young daughter’s sentiment struck him with an enormity of emotions that were far from simply pride and joy. A true “daddy’s girl,” the pair shares the same hair color and a love of swimming, tennis and boating. His eldest daughter even loves to tag along with John at work, where she has her very own office. But when Julia , 11, was diagnosed with type 1 diabetes, it was one thing John hoped they would never have in common.

“The day I found out Julia had diabetes was probably the most difficult John Reisman with daughter Julia . day of my life. Much harder than the day I was diagnosed. It couldn’t even compare,” said John, who has been living with this disease “This disease is epidemic, not only in our family but in the world today. since he was 14. We need to find a cure,” stated Kim. “My family and I believe the DRI is the best hope for a cure, and we want to focus our fundraising efforts While John was away on business, his wife, Lisa , recognized a telltale on the Institute.” sign in Julia, who was 7 at the time. “It was her sweet-smelling breath – something Lisa had recognized on me when I had high blood sugars. She Kim and John hail from a family of philanthropists, most notably took Julia to the hospital and said to the nurse, ‘I think my daughter has their maternal grandparents, Norma and Jack Parker , who created diabetes. Test her,’” John recounted. “When the nurse questioned her, the Jack Parker Foundation. This family foundation supports various Lisa said, ‘I just know.’” charities, mostly medical-related, such as the Parker Jewish Institute for Health Care and Rehabilitation and the Diabetes Research Institute. Unfortunately, John’s family knows the signs and symptoms of diabetes John is also the president of The Jack Parker Corporation – Florida, a all too well. His grandmother and great grandmother had type 2 . real estate development company located in Fort Meyers. Following Julia’s diagnosis, his mother, Jane Parker , also developed type 2, and his aunt was diagnosed with type 1. “My grandparents used to say, ‘It’s so much easier to give than to ask,’” said John fondly, and he tries to pass this trait along to his own Finding a cure has become the family’s top priority and they have chan - children, Julia and Jayda , 9. neled their efforts in support of the Diabetes Research Institute. Earlier this year, Lisa and John, as well as Jane, each served as Platinum Sponsors John recently toured the DRI in Miami, spoke with the scientists and of the Foundation’s D.R.E.a.M.S. in the City event. One of John’s four sis - saw firsthand the life-saving work being conducted there. “I was very ters, Kim Dickstein , joined the Foundation’s Northeast Regional Board impressed and felt that the DRI is probably our biggest hope to finding and is very active in helping to raise funds and awareness for the DRI. a cure. If you have faith and dedication, it will happen,” he concluded.

1 2 3 4 5

6 CYCLE OF DISCOVERY AWARDS HYPOTHESIS AWARD: (1) Barbara Annis , (2) Ric Carter of Fluor Construction QUERY AND HYPOTHESIS AWARDS : (3) Don Strock presents to Mary Jo (not pictured) and Bruce Schumin . (4) Barbara Singer presents to Elizabeth and Gary Hall, Jr., with baby Charlie . QUERY AWARD: (5) Irwin Hochberg , (6) Mordechai Lebenberg of KNR Constructions

Hypothesis represents gifts of $50,000 or more. Query represents gifts of $25,000 or more. For a description of the DRI Foundation's Cycle of Discovery donor award program, please visit www.diabetesresearch.org.

5| DRI DEVELOPS FIRST EVER “LIVING WINDOW” AROUND to View Transplanted Islets

THE DRI For the first time ever, scientists can view transplanted insulin- producing islet cells in real- time. As published in the DRI DISCOVERS prestigious journal, Nature Medicine , DRI researchers IMPORTANT REGULATOR used a sophisticated non- invasive imaging system to OF BLOOD SUGAR observe how islets develop > Continued from Page 1 blood vessels and nerves following transplantation. neurotransmitter which facilitates the release of glucagon. The DRI team, directed by Neurotransmitters are chemicals that relay, amplify and Dr. Per-Olof Berggren from modulate signals between a neuron and another cell. the Karolinska Institutet in Sweden, selected the anterior “We learned that glutamate acts as a positive signal that chamber of a mouse’s eye as instructs alpha cells to speed up glucagon secretion in order a“living window” to monitor to prevent glucose levels from falling too low ,” said Dr. Caicedo. islets in a live model. This process prevents hypoglycemia in those without diabetes, as well as in islet transplant recipients. “We chose this unique site because the eye offers a The prestigious journal, Nature Just how the body regulates the correct amount of glucagon virtually unobstructed view wasn’t clear until now. Medicine , featured the DRI’s ground - breaking study on the cover, showing through the transparent “It is this signal pathway that is our discovery, ” says the image of an islet (in red) engrafted cornea ,” explained in the anterior chamber of the eye, with Dr. Alejandro Caicedo from Dr. Berggren, head of Cell Biology and Signal Transduction the dense blood supply to the islets at the DRI and head of Experimental Endocrinology at the (in green). the DRI’s Islet Physiology lab. Karolinska Institutet. “ This interaction between beta cells “By implanting islets in the eye, and alpha cells is crucial for normal blood sugar regulation. ” we are able to follow the same cells over time and assess their function as well as the immune system’s The researchers also noted that when beta cells do not response to the transplanted cells.” produce insulin, the alpha cells’ signal pathways are blocked, which eliminates their ability to respond to changes in glucose . This novel viewing platform gives researchers unprecedented Therefore, in those with type 1 diabetes whose beta cells opportunity to observe the effects of new drugs on islet engraftment, function, regeneration and their ability to prevent rejection. have been destroyed this entire cell process is hampered. “Until now, scientists had no way of directly viewing and monitoring “We are now designing strategies to test the use of the neuro - the biological processes of islets upon implantation,” explained Dr. transmitter glutamate, which is critical to this mechanism, to Camillo Ricordi , scientific director of the Diabetes Research Institute. determine if we can prevent hypoglycemia in patients who require insulin, ” says Dr. Caicedo. That’s because in clinical trials islets have been infused into the liver, making it impossible to view their activity in real time.The liver, which To view a video featuring Dr. Berggren speaking on this is easier to access than the pancreas, provides a rich network of blood novel work, please visit www.diabetesresearch.org. vessels. However, similar to their native environment in the pancreas, islets are scattered throughout and deeply embedded in the organ. The Islet Physiology team is continuing these studies and exploring the potential use of the eye as a transplantation site for pilot clinical trials. DRI Presents Results of Continuous Glucose Monitoring Study

Investigators from the DRI’s Clinical IsletTransplant Program showed that the use of continuous glucose monitoring systems (CGMS) in islet transplant recipients can provide important data to assess how the transplanted cells are working. In recent years, improved technology has provided clinicians and patients alike with the ability to monitor blood sugars around the clock in‘real- time’. Rather than a snapshot of a single blood sugar reading or a three-month average with a Hemoglobin A1C test, multiple readings per hour are able to plot patterns and impact regimen changes. In a study conducted by DRI researchers, CGMS was used to assess metabolic control in 25 patients with type 1 diabetes, including 12 who had previously received islet transplants.The participants were monitored for three consecutive days and repeated every three months during the 18 month study. “We found the continuous glucose monitoring system to be useful in telling us how well our patients were doing after their islet transplant,” said Lisa Gorin, DO , a third-year fellow in endocrinology, diabetes and metabolism at the Diabetes Research Institute.The results were presented at Mastering Your Diabetes is a unique educational program for people with diabetes and their families.

Participants of diverse ages, professions and nationalities over - whelmingly report that MYD is a life-altering experience for them...

MASTER YOUR DIABETES THROUGH INNOVATIVE DRI PROGRAM

Insulin therapy is essential for life in those with type 1 diabetes has gained a newfound knowledge of diabetes and his ability to and is an increasingly required therapy for people with type 2 control blood sugar. He has regained physical well-being and self- diabetes. Perhaps there is no other condition that requires so much confidence and now feels in control of his life. In fact, he wants to diligence and proactive management on a minute-to-minute basis help others gain that same control. “I have felt an extremely strong to achieve normal blood sugar control. To provide the level of urge to help other diabetics that are in the same place that I was in knowledge needed to accomplish this, the DRI has designed an prior to attending the MYD class.” (To read a letter from Todd, please empowering diabetes self-management program, Mastering Your visit the Mastering Your Diabetes area of our website at Diabetes (MYD) , which is a unique educational and experiential www.diabetesresearch.org/DiabetesEducation&Management) program for individuals using insulin therapy and for their family The expert education team is led by Dr. Luigi Meneghini , director members or significant others. of the DRI’s Kosow Diabetes Treatment Center, and is comprised This comprehensive five-day program provides insulin management of nurse practitioners, nurse educators, dietitians, psychologists, education and the necessary tools to make informed decisions and endocrinologists. The interactive and experiential components about blood glucose interpretation, insulin management and the of the MYD Program include daily review of personal blood glucose factors that influence diabetes control, all with the purpose of records, insulin management options, activities to enhance profi - promoting a flexible lifestyle and optimizing health outcomes. ciency in carbohydrate counting and opportunities for participants to explore and express the impact of diabetes on their lives. One of the keys to the success of MYD is the unique perspective brought by each participant. So while MYD is a group-based Participants receive comprehensive education and medical evalua - program, it ensures achievement of individual needs. tion prior to the start of the course. During the program, laboratory test results are reviewed as a way to teach standards of diabetes Participants of diverse ages, professions and nationalities over - medical care. This review also enhances skills for improved patient- whelmingly report that MYD is a life-altering experience for them, health provider interactions. providing unique opportunities to interact with others with diabetes and explore their self-management decisions in a supportive team MYD is offered four times a year, and program participants benefit environment. Participation provides a better understanding of how from regular follow-up, support, and annual updates on state-of- blood glucose levels respond to various lifestyle and therapeutic the-art scientific advances. changes, assisting participants in developing improved problem- For more information, please contact Arleen Barreiros , the DRI’s solving skills and the ability to live more confidently and with education coordinator, at (305) 243-3696 or visit greater flexibility. www.diabetesresearch.org. Todd Dunnahoe , a recent MYD participant from Texas, wrote, “Prior to attending the MYD class, I felt hopelessly out of control, like there was nothing I could do to change anything. The MYD class has com - pletely changed my life.” Todd, like many other MYD participants,

the American Association of Clinical Endocrinologists 17th Annual Meeting & Clinical Congress. Dr. Gorin was recognized for her oral presentation receiving First Prize at the conference. CGMS can be a useful tool as an indicator of islet graft function and the metabolic effects of islet replacement therapy. “We found that those participants who had undergone islet transplantation had significantly fewer episodes of hypoglycemia throughout the study period,” said Gorin. “They also spent longer periods of time in the normal glycemic range with overall improvement in glucose control and metabolic stability. “We hope that with the use of real time continuous glucose monitoring we can better predict islet graft function, thus allowing us to intervene earlier in the disease process,” Gorin concluded. The Clinical IsletTransplantation Program is currently screening individuals for participation in a new islet transplant trial.This trial is part of the National Institutes of Health (NIH) Clinical IsletTransplant Consortium (CIT).The new trials are aimed at extending long-term islet function and improving anti-rejection drugs.

7| UNDER THE MICROSCOPE with Alessia Fornoni, M.D., Ph.D.

Type 1 diabetes is an auto- nephrin facilitates islet cell function. Ensuring effective insulin immune disease in which signaling and maintaining proper islet cell function is probably one an individual’s insulin- of the best ways to go about finding a cure. producing beta cells are Q. Can nephrin facilitate the development of insulin-producing cells? mistakenly destroyed by his/her own immune system. While the actual cause of this autoimmune attack is still under investigation, A. Nephrin expression is critical for mature kidney cell development. researchers are uncovering a number of key factors that lead to Knowing this, we are planning studies in collaboration with DRI’s stem the onset of the disease. cell development team to explore the role of nephrin in the generation of insulin-producing cells from immature cells known as precursors. In recent years, scientists have discovered that chronic inflammation plays a major role in islet loss. DRI researchers are now testing Q. What brought you to the DRI? numerous anti-inflammatory agents to prevent islet destruction A. I obtained my M.D. and Ph.D. in Medical Pharmacology at the while exploring how the different cells that make up the Islets of Universita’ degli Studi di Pavia in Italy. I later joined the Renal Cell Langerhans function. These cell clusters are responsible for regulating Biology lab in the Vascular Biology Institute at the University of and maintaining normal blood sugar levels. A better understanding Miami Miller School of Medicine. I continued my medical education of the factors that lead to beta cell loss and contribute to normal at UM, where I currently work as a clinical nephrologist treating many beta cell function will help in developing strategies to restore diabetic patients. After being appointed assistant professor in clinical natural insulin production in those living with diabetes. medicine at UM in 2005, I had a strong desire to join a research insti - Scientists are identifying many of the key molecules involved in tution committed to curing diabetes, and I was very fortunate to have islet function. Among these is nephrin, a promising new therapeutic the opportunity to join the DRI team. I’ve always thought of diabetes target. Nephrin, derived from the Greek nephros, or kidney, is a sub - as a slow but persistent “Pac Man” that will slowly take over patients’ stance essential for optimal kidney filtration, which eliminates toxins bodies and souls. Here, my training and research successes in diabetes produced by the body, as well as for the retention of certain and diabetic complications can be quickly translated from the lab to molecules needed for a person’s survival. patients. The commitment of the DRI’s scientific director, Dr. Camillo Ricordi , to finding a cure and his ability to harness talent from multi - Although nephrin was thought to be a kidney-specific molecule, disciplinary areas of expertise are among the DRI’s biggest strengths scientists recently discovered it in the pancreas, where its actual and was a major reason for my joining the institute. role still needs to be fully understood. However, recent findings suggest that there is a link between the development of type 1 diabetes Q. How does this multidisciplinary environment benefit your and nephrin, thought to be a target of autoimmune attack. research efforts? At the DRI, Dr. Alessia Fornoni , assistant professor of clinical medicine A. At the DRI, my interaction with cell biologist Dr. Per Olof Berggren in the Division of Nephrology and Hypertension, and her colleagues is critical to characterizing the role of nephrin in insulin secretion. have generated preliminary results showing that beta cells express The enthusiasm and encouragement of Dr. Ricordi; expertise of nephrin and that this molecule is vital for beta cells to secrete immunologists Drs. Luca Inverardi and Alberto Pugliese ; intellectual insulin in response to blood sugar. support and technical assistance of Dr. Antonello Pileggi and molec - ular biologist Dr. Ricardo Pastori ; as well as mentoring of physician In diabetes, nephrin expression in the kidneys is reduced, which scientists, such as Dr. Daniel Mintz , will be instrumental in finding contributes to the development of diabetic kidney disease. Dr. Fornoni a cure. I also have a close interaction with Dr. Jochen Reiser , recently has demonstrated that this decrease of nephrin is also seen in beta recruited from Harvard Medical School to become chief of nephrology cells of patients with diabetes. and hypertension at UM; Dr. Peter Mundel , basic science research To further investigate this connection, Dr. Fornoni and her team are director of UM’s Division of Nephrology; and Dr. Karl Tryggvason , the using mice, lacking nephrin in the pancreas, to assess the protein’s scientist who discovered nephrin in the kidney. I’m excited about the potential to prevent type 1 diabetes and also to delay the need for recruitment of researchers with different scientific backgrounds and insulin injections in those with type 2 diabetes. believe this strategy will be pivotal in leading to new discoveries. Q. How does your research fit in to the DRI’s cure-focused mission? Q. What are your future research plans and how will that help find effective treatments? A. Evidence that both type 1 and type 2 diabetes are chronic inflammatory states led me to study the function of novel anti- A. I believe that understanding and improving beta cell function is inflammatory agents for the treatment of diabetes. Inflammation necessary for finding a cure for diabetes. By knowing more about how affects the ability of insulin to signal through its own receptor and beta cells work, we can develop strategies to better preserve islets and to maintain proper cell function and survival. If we overcome insulin’s protect cells from the dangerous effects of anti-rejection drugs, inflam - inability to signal, we can recover islet survival, function and viability matory agents and the immune system. Nephrin is probably just one after exposure to inflammatory stimuli. We have generated prelimi - of the pieces of the puzzle but, once the puzzle comes together, a cure nary evidence that this could also be the mechanism by which will be found. My patients are the driving force of my research. Help, Heal, Inspire and Inform THE BENEFITS OF ONLINE COMMUNITIES Support Our Work While Doing Yours

What the DRI Foundation’s PEP Squad (Parents Empowering Parents) has Many companies encourage employees to support chari - discovered through its outreach to “diabetes families” across the country is table organizations through workplace giving campaigns. that several newly diagnosed kids and parents feel isolated in their local com - These gifts are tax deductible and can be made through a munities. There are countless cases where the child is the only one with diabete s payroll deduction program. Simply select the DRI Foundation at the school, and the family has no one to turn to for advice or simply an from your company’s charitable choices and encourage understanding ear from someone in the know. Many families, however, have your co-workers to do the same. If the Foundation is not already discovered that online communities, social networks and web logs already an option, you can further assist by working with (blogs) bring the global diabetes community to your living room (or wherever us to determine how to go about being included. your PC/laptop might rest!). For participants in the Combined Federal Campaign (CFC), One of the first online diabetes communities that emerged and that our number is #11149 . We are also listed under the Health 1st continues to be one of the most trusted diabetes resources on the web is America’s Charities Federation. The easiest way to find us is ChildrenWithDiabetes.com (CWD). Founded by Jeff Hitchcock in 1995, the site in the alphabetical index at the back of your campaign offers a thriving support system and allows families to share experiences and guide. If your company holds a United Way campaign, you connect with each other. have the opportunity to contribute to the DRI Foundation by utilizing the write-in feature. Please call 1-800-321-3437 “As a parent of a now young adult with type 1 diabetes, I am very optimistic about or email [email protected] if you have any questions. my daughter’s future. Throughout the world, many doctors and scientists are working very hard to unlock the secrets of type 1 diabetes,” said Jeff, who created the site in response to his daughter’s diagnosis at the age of 2. “Until the day that type 1 is no longer, Children with Diabetes helps families and kids to live well with diabetes. Together, as a community, we learn and share and offer support.” In 2000, CWD held its first conference for 110 families who gathered for camaraderie and fun. Today, the conferences have grown to become the most amazing educational and support experiences for families who have kids with diabetes. The Diabetes Research Institute and Foundation have been involved since the very first year, and at the 2008 Friends for Life Annual Conference in July, which attracted more than 3,000 people, the DRI’s Dr. Norma S. Kenyon and Dr. Cherie Stabler gave informative presentations for both parents and kids. Be Entertained & Educated Online What has quickly become the coffee shop of the 21st century is the online social network, a place “where everybody knows your name” - or user name - In recognition of National Diabetes Awareness Month, the where you can go to connect with others, socialize and exchange ideas. And no, DRI Foundation will run its first online webathon throughout parents, it’s not just for your teenagers! There’s a social network out there for November to raise funds and awareness. Offering entertainment everyone: saving time in our busy lives, allowing us to meet others with similar as well as education on diabetes and the DRI, the webathon interests, and offering one-on-one contact as our own schedules permit. will feature online auctions, play-for-the-cure tournaments, healthy lifestyle segments, comedy acts, messages from TuDiabetes.com Two very popular diabetes social networks are , where users celebrities, and much more! Linda and Barry Gibb will serve write blog posts, exchange ideas in discussion forums, and share photos and as International Hosts, and Larry the Cable Guy , Sugar Ray Diabetestalkfest.com helpful videos, and , which is dedicated to live scheduled Leonard , Roy Firestone , Lance Burton , Smokey Robinson , and chats with medical professionals, scientists and nutritionists and also live Bret Michaels have already signed on to lend their talent. daily chats to help connect people with diabetes coast to coast. These sites encourage users to discover new people and new possibilities; they turn Tune in to www.DiabetesWebathon.com for updates! distant strangers into friends with a click of the mouse; and they provide access to a variety of people with diabetes from around the globe. Other great online resources are diabetes blogs, such as Amy Tenderich’s DiabetesMine.com and Scott’s Web Log by Scott Strumello (sstrumello.blogspot.com). A popular on-line interactive diabetes site, dLife.com offers comprehensive information directed toward empowering those with diabetes, their familiy members and other caretakers. These sites and others offer personal accounts and life stories, different perspectives on the latest tools, technologies and scientific research, information on variety of diabetes management issues, plus the opportunity for readers to review and respond. Most of all, online communities allow you to learn, connect, help, heal, inspire, inform and relate. Don’t delay in getting involved. To find out about additional online resources, visit www.diabetesresearch.org/links . To get connected to a PEP Squad member, find the link on our homepage or call 1-800-321-3437.

9| LET ME COUNT THE WAYS TO GIVE There are so many different ways to Shown here with DRI Scientific Director contribute to the Diabetes Research Camillo Ricordi, M.D. , Kelli Klein (right) and Institute Foundation. Below is a short her mother, Marci , were impressed by their tour of the DRI and are thrilled to support list of easy ways to give and we have the DRI with Dog Tags 4 Diabetes. additional ideas posted on our website. Visit diabetesresearch.org/Foundation, then click Ways to Give, Generous Partners or Links. Honor and Memory Gifts THE FUTURE Looking for a unique way to show that you care? Keep the memory of loved ones alive or honor someone special for OF PHILANTHROPY a birthday or milestone. The Foundation will notify that individual or family What does the future of philanthropy look like? Could it possibly resemble a boy band and member and send you a confirmation of its fawning tween fans? In the case of one young philanthropist helping to forge the way your thoughtful gift. Call 1-800-321-3437 for her generation, it does! or visit the above web link. Currently rampant among teenage girls nationwide, OJD is defined in the urban Online Giving – At no cost to you! dictionary as Obsessive Jonas Disorder, a frenzied fascination with everything relating The DRI will receive a donation to pop-rock stars, the Jonas Brothers. For 16-year-old Kelli Klein , the affliction provided just from you doing the things you the ideal market audience for the perfect fundraising opportunity, one which combines do every day. the love of her favorite band with her desire to help cure one of its members. • Shop online at GiveBackAmerica.org A huge fan of the Jonas Brothers for about two years, Kelli has attended several of their • Use GoodSearch.com as your shows, keeping track of Kevin, Joe and Nick Jonas via the Internet in between. As she preferred online search engine watched the New Jersey siblings rise to superstardom, Kelli also witnessed OJD sweep • Plan your wedding at the nation…and a metaphorical light bulb turned on. IDoFoundation.org • Donate your car through When the Jonas Brothers performed at the DRIF’s Carnival for a Cure in New York City in Cars4Charities.org March of 2007, Nick, the youngest brother, revealed that he has type 1 diabetes. Since then, millions of fans all over the world have watched the video taken at the event. It Generous Partners was in this way that Kelli learned about the DRI and realized her desire to help support The DRI Foundation has partnered its work toward a cure. And when she noticed Nick wearing a medical ID tag and with multiple companies that offer realized that his fans would want to wear one in support of him, she put her enjoyable products and donate a thoughts into action. portion of their sales to support the DRI's cure-focused research. With a business mind beyond her years, the high school student excitedly described • Drink VitaZest® if you love vitamin her plan to her mother. They ordered samples of dog tags from various vendors, chose and fruit enriched water – one, and purchased 100 dog tags engraved with the words, "Support Diabetes, Support drinkvitazest.com Nick." Kelli then created MySpace and Facebook pages, which she named “Dog Tags 4 • Rejuvenate at Canyon Ranch, Skana Diabetes.” Immediately, she began receiving orders for the dog tags and soon she was or Miraval Resorts if you love spa thrilled to deliver her first check for $800 to the DRI Foundation. And as of now, Kelli’s destination get aways – project has raised more than $6,500 for the DRI. [email protected] “I am so proud of how far Dog Tags 4 Diabetes has come, and I hope the success contin - • Order the Swingdicator to improve ues,” Kelli said. Referring to the Jonas Brothers’ title track from their upcoming album, your golf game – swingdicator.com out August 12, she continued, “I strongly believe if we work together, Nick and the millions • Enjoy HoneyTree’s Sugar Free Imitation of others dealing with diabetes will only have to wait A Little Bit Longer for a cure.” Honey – honeytreehoney.com If every kid was doing what Kelli is doing, we’d have a cure! This is the future of philanthropy.

JOIN US AT DIABETES 2.0 New Venue! New Format! What’s next in diabetes research and treatment? What’s available now? Is it hype – or hope? DIABETES 2.0 The 7th New York Research Update will answer these questions and more on Saturday, Harnessing New Technologies October 25, at the Marriott Marquis in New York City. For an agenda of the daylong in Research and Treatment conference and to pre-register, visit www.diabetesresearch.org . ENJOY HONEYTREE’S SUGAR FREE IMITATION HONEY AND A sweet-tasting substitute for those SU PPORT THE DRI who love honey. Most folks love the good, sweet taste of honey. Now, people with “More and more adults – and parents – are taking a proactive role in diabetes and those looking to reduce their sugar intake can also enjoy their family’s healthful habits and specifically nutrition. Small changes this delicious treat with HoneyTree's Sugar Free Imitation Honey. To in diet, such as reducing sugar intake, can make a huge impact, especially sweeten the deal, HoneyTree, Inc., a top quality honey supplier with for people with diabetes or who are at risk of developing diabetes,” said a 90-year history, donates a portion of product sales to the DRI. Robert A. Pearlman , president and CEO of the Diabetes Research Institute Foundation. “We are grateful for HoneyTree’s support of our mission to The Diabetes Research Institute Foundation and HoneyTree, Inc., cure diabetes and for their concern for all people affected by this disease.” recently announced this new partnership that indicates the honey manufacturer’s commitment to supporting the cure-focused work Consumers can find HoneyTree’s Sugar Free Imitation Honey and being conducted at the DRI. The Foundation logo will appear on the other HoneyTree products in select grocery stores and drug stores label of HoneyTree’s Sugar Free Imitation Honey to help consumers nationwide, or they can order directly from the company’s website, easily identify a great-tasting alternative. www.honeytreehoney.com . With its golden color, smooth honey-flavored taste and thick, flowing “HoneyTree is pleased to have an opportunity to give back to the dia - consistency, HoneyTree’s Sugar Free Imitation Honey is the ultimate betic community. We are privileged to support a research focused or - honey substitute. It can be used in place of honey in recipes, as a top - ganization such as the DRI Foundation in its efforts to find a cure for ping for toast, breads and cereals, or as a sweetener in tea and coffee. diabetes,” said Bob Olney , HoneyTree’s president.

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1. Sammy Schechter proudly presented DRIF’s Jill Shapiro Miller with a check, signed by his entire 2nd grade class. DIABETES DIPLOMATS DEMONSTRATE: 2. Shannon Painter (center) coordinated The Benefit in Chicago in honor of her friend, Alyssa LeVine (right.) Also pictured is Alyssa’s husband, Cory LeVine . 3.(l-r) Lorraine , Carol , and Michal Nudelman plus Morton Blumberg , support the DRI IT ALL ADDS UP with hope of a cure for Ashley Blumberg . As the prevalence of diabetes rises, so does the amount of people who have a connection to the disease. When these individuals act upon the desire to “do something” for themselves or on behalf of their loved one with diabetes, then colossal results are achieved. Following are just a few examples of Diabetes Diplomats of varying ages and geographic locations who are showing that it all adds up for the DRI.

Recently diagnosed with type 1 diabetes, 8-year-old Sammy Schechter Even further west, in Colorado, Carol Nudelman , along with her husband, helped his parents, Beno and Rosa Schechter , produce a DVD of Beth Morton Blumberg , and her father, 92-year-old Michal Nudelman , were Am Day School’s 2nd Grade Chanukah Celebration Show, which he spreading the word of the DRI to another group of people. Motivated offered to his classmates for a donation. Sammy was deeply touched by 18-year-old Ashley , Carol and Morty’s daughter who has been deal - and amazed as he opened the envelopes and saw the amounts con - ing with type 1 diabetes for seven years, they began a letter writing tributed by his classmates. Beating his goal of $1,000 by a landslide, campaign in 2002. Each year, the campaign has raised approximately Sammy was excited to present “a big fat check” for $5,575.50 to the $20,000 for the DRI. While Carol initiates the effort, Morty helps her to DRI. In response to his father’s gentle warning that the money may fine tune and personalize each letter, and they send them out to family only last 15 minutes in the DRI's labs with such expensive equipment, and friends across the country. Michal personalizes his own letters and Sammy said, “Who knows…maybe just like in Chanukah, the miracle- reaches out to his and his wife, Lorraine’s friends and family. “Just as cure could be found in those 15 minutes and last for a life-time.” polio was eradicated in our lifetime, so can juvenile diabetes become a historical footnote,” their letter expressed this year. As efforts across While Sammy and his classmates were busy in Florida, another Diabetes the country are combined, it is clear that it all adds up when you are Diplomat, Shannon Painter , was hard at work in Illinois. In honor of her an advocate of the DRI. friend, 27-year-old Alyssa LeVine , who was diagnosed with type 1 at age 6, Shannon coordinated The Benefit, held at Level nightclub in Chicago Please contact the DRI Foundation at 800-321-3437 if you would like on April 19. More than 200 guests attended the trendy event, sipping to become a Diabetes Diplomat to raise funds and/or awareness for cocktails and nibbling on sushi as they enjoyed music spun by popular the DRI. You can also send an email to [email protected] or visit deejays. The evening peaked with a fabulous spring fashion show, fea - www.diabetesdiplomats.com for more information. turing the work of top designers. Proceeds benefited the DRI, and thanks to Shannon, awareness of the DRI reached additional Midwesterners. 11 | ARMANI EXCHANGE SUPERMODEL STEPS OUT FOR THE DRI Proving that giving never goes out of style, super - Izabel’s 7-year-old brother was diagnosed with model Izabel Goulart , along with Armani Exchange, type 1 diabetes five years ago. Since then, she has raised $10,000 for the DRI in just two hours on May worked with hospitals in her native Brazil to raise 3 in New York City. Starring in the Armani Exchange money to provide free insulin for diabetic children (A/X) Spring 2008 advertising campaign, the Brazilian in need. Upon hearing of the DRI, Izabel expressed beauty greeted her fans at the SoHo A/X store, her belief that the message was a Godsend graciously autographing her photos and handing because she sincerely wants to find a cure. out DRI information. More than just an angel to the DRI, Izabel has “I am here with all my love to raise money for the been a Victoria’s Secret “Angel” since 2005. She Diabetes Research Institute,” Izabel said. “I am 100 has sashayed down the runway wearing duds by percent positive that one day they’ll find the cure.” top designers such as , , Valentino , , , and DRI Foundation President and CEO Robert A. Pearlman Stella McCartney , among others. She also had her was on-site to present Izabel with a certificate of television debut last year in an episode of appreciation for her support of and dedication to HBO’s Entourage . the cause, one that is as close to her heart as it is to so many others. The DRI looks forward to a lasting relationship with Izabel Goulart, a woman whose beauty is not “This is such an honor for me,” the 23-year-old just skin deep. sensation said earnestly. “I have someone in my Supermodel Izabel Goulart , new friend of the DRI. family who suffers from diabetes.”

DIAMOND ANNIVERSARY, CRYSTAL BALL More than 400 guests gathered at the Garden “It’s going to take a facility like the Diabetes Other top sponsors included Wright Risk City Hotel for the 10th anniversary of Long Research Institute down in Miami to find a Management; Congdon, Flaherty, O’Callaghan, Island’s premier DRIF event, the Crystal Ball. cure for this disease. With the money we Reid, Donlon, Travis & Fishlinger; The Weitz According to Gala Committee Chairman raise here tonight, we will find a cure,” Family Charitable Foundation/Weitz & Charles Rizzo , the elegant affair, held on added Michael. Luxenberg Law Offices; ACE INA Foundation; May 3, raised $792,000. AIG Insurance Companies; Kenneth and During the dinner program, which was led Jane Hirsch and the Seaman Family The tremendous success of the event can be by WCBS-TV’s Dr. Max Gomez , DRI Associate Foundation; and Rooms to Go Children’s attributed in part to the dedicated support Director Dr. Norma Sue Kenyon explained Fund. The Grand Ballroom was transformed of the evening’s honorees, Jodi and Michael some of the research underway. She further into a sophisticated supper club thanks to Genatt , and the recipients of the Gillin Fam - connected with the crowd by discussing her Lawrence Scott Events, the producer and ily Humanitarian Award, Michael’s parents, personal sense of urgency as a scientist and underwriter of the evening's design and Judy and Les Genatt . The family has taken a mother of a teenager with type 1 diabetes. decor. Thanks to the Kossoy , Auerbach and on the search for a cure as a personal mission Touched by her words, the audience re - Landow families , guests went home with ever since Jodi and Michael’s 15-year-old son, sponded with generous gifts during the a variety of goodies, such as beautiful pash - Zach , was diagnosed with type 1 diabetes Fund-A-Grant portion of the program, in - minas, limited edition frosted glass water five years ago. cluding significant contributions from the bottles handcrafted with Swarovski “Diabetes affects the entire family. It Future Leadership Foundation, Roberta and Crystals, and Crystal Ball tote bags. changes your whole life,” said Jodi, personally Bruce Waller and Family, Martin Granowitz , thanking everyone in the room for their the Genatt Family and Genatt Associates, attendance and support. Inc., and Joan and William Fishlinger .

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1. Honorees Michael and Jodi Genatt (left) with their son, Zach , and Judy and Les Genatt , Gillin Family Humanitarian Award recipient s.

2. Gala Committee Chairman Charles Rizzo , and his wife, Marie. NEW ENGLAND PATRIOTS' VINCE WILFORK'S MANTRA: ONE LIFE TO LIVE Considered one of the finest defensive tackles in the NFL today, New England Patriots’ Vince “Big Daddy” Wilfork is also a fine example of a son who took his father’s words to heart. Vince’s philanthropic actions, as well as the tattoo on his upper arm, reflect the mantra of David Wilfork, Sr.: One Life to Live. For more than half of his 26 years, Wilfork witnessed his father struggle with complications of diabetes. In 2002, while he was attending University of Miami, he sadly received news that his father and best friend had lost this battle. And since then, Wilfork has bravely turned Vince and Bianca Wilfork raised more than $100,000 for the his heartache into an ongoing fight for life. DRI with their 5th Annual Draft Day fundraiser. “I am trying to help find a cure for diabetes so that maybe one day I can prevent a son or daughter from losing their mother or father to the disease,” Wilfork said. commentary, while enjoying food, drinks and raffles, plus live and silent auctions. PlayStation’s Madden and bowling tournaments kept Organized by his wife, Bianca , and supported by friends, family and the fun rolling. teammates, including Randy Moss, Ty Warren, Kevin Faulk, Santonio Thomas, Pierre Woods, Lonnie Paxton, Logan Mankins and Ellis Hobbs , Proceeds exceeded $100,000 this year, more than double from last Vince Wilfork’s 5th Annual Draft Day Fundraiser was held on March 15 year and ten times the amount the first event raised, when Vince him - at PiNZ in Milford, MA. More than 800 fans from throughout New self donated half of the $12,000 proceeds. The DRI is grateful to call England and across the Eastern Seaboard attended the party, eagerly Vince and Bianca Wilfork, along with their son, D’Aundre , and daugh - anticipating the chance to interact with their favorite nose tackle ter, Destiny , friends and partners in the quest to cure diabetes. Don’t while watching the draft on three gigantic projection screens and a miss out on this wonderful family’s 6th Draft Day fundraiser, which is multitude of televisions. Guests were treated to professional draft certain to be even bigger and better than ever!

Don Strock Diabetes Classic CELEBRATES A SILVER ANNIVERSARY

Presented by Miami Seaquarium and supported With maturity beyond their nine years, Brooke Generous sponsors: Back (l-r) largely by the produce industry, the Don Strock Miller displayed the bulky diabetes-related contents Tournament Host Don Strock , Diabetes Classic attracted 175 golfers to Miccosukee of her purse and Hunter Cope explained how her Chairman Bruce Fishbein of The Produce Connection, Terry Willie Golf and Country Club on May 14, raising more diabetes dog and constant companion, Diva, senses of Miccosukee Tribe of Indians of than $175,000. In honor of the 25th annual tour - when her blood sugar is too high or too low and Florida, name unavailable. Middle nament, fellow current and former pro-athletes then alerts one of her family members. Brooke’s (l-r) John Spicei of Taylor Farms of Dan Marino, Dwight Stephenson, Nat Moore, Jim mother, Lynette Miller , shared further examples Florida, Jim McGrath of Outback Jensen, , Don McNeal, , Kim of how the disease affects the whole family. Steakhouse, Andrew Hertz of Miami Seaquarium, a representative Bokamper, Harvey Clayton, Tony Fiorentino, Eddie Matthew Sanchez, Ellie Tamminga and Armand of Tropical Shipping, Mike DeGiuseppi Hill, Quadtrine Hill, Ricky Jackson, John Harris , and of Minuteman Press of Boca Raton, Guim also addressed the teary-eyed crowd, and Twan Russell joined Don Strock on the course. John Marini of Heineken USA, the universal hope of all children with diabetes Floyd Seskin of Uro-Club, Jeff Pfaff “Dan Marino was a rookie the first year we had was summed up in ten words: “My dream is just of Top Tomato, Adam Homan of this tournament,” Strock quipped. “That gives you to be a regular kid again.” Six L’s Packing Company, and some perspective on just how long we’ve been Morris Corbitt of The Produce “You’ve just heard firsthand the reason for this Connection. Front (l-r) Doug doing this.” tournament,” said Barbara Singer of the DRI Tannehill of C.H. Robinson World - After enjoying perfect weather on the course, Foundation. “With our help, these kids can look wide, Paula Pippin of Coca-Cola, Robert Piper and Jerry Share of the spirited group tackled cocktails and dinner, forward to a future free from diabetes.” Sheds Plus, and Bruce Schumin of plus live and silent auctions. When seven special Bruce Fishbein , event chairman since inception, M & R Produce Distributors. Not guests took the stage, silence overcame the pictured: American Fruit & Pro - then announced with pride that the Classic’s noisy dining room. duce, Miccosukee Championship, cumulative proceeds have now surpassed the Florida Mushroom, Freedom Fresh, “My little brother is a hero,” said Emilio Lamar, Jr. , $2 million mark. Sierra Produce, The Oppenheimer age 13, speaking of 11-year-old Felipe , who has type Group, Capital Produce Distribu - tors, Crystal Springs and Warren 1 diabetes. “He has to be much more responsible Henry Automobiles. than other kids. And he never complains.”

13 | EVENTS

LONG ISLAND REGION

Springing Forward

More than 350 women attended Spring into Fashion, presented by Roberta and Bruce Waller and Family, at the Carlyle on the Green in Bethpage State Park. A decade ago, dear friends Addy Fritzhand (2nd from left) and Miriam Marlowe-Shiff (right) started the event, and this year they were honored for their dedication as co-chairs. The elegant luncheon was followed by a fashion show featuring the spring collection , provided by Marshs. Honorary Chairman Senator Craig Johnson and DRI’s Gary Kleiman were on-hand to congratulate current Co-chairs Doreen Peykar (2nd from right) and Rina Weinbrom (left) on a successful event, which raised $214,000.

In Heart & Mind

The family of Helaine Shari White continues to celebrate her incredible love of life and powerful spirit with fundraising events that focus on laughter, fun and family. Her parents, Rhoda and Donald White , and her two sisters and brothers - in-law, Peter and Hillari Boritz and Renee and Ron Spiegel , organized the eighth annual Lanie's Lanes at the East Meadow Bowling Lanes. Keeping Lanie in heart and mind, the family raised more than $28,000 for the DRI this year. Pictured bowling are Marti Motherway and his granddaughter, Caitlyn Bella .

EMPIRE BALL

Another Empire Record

The 2007 Empire Ball, which was chaired by Peter DiCapua , was held at the Grand Hyatt Hotel and raised more than $1.4 million. Sponsored by the Real Estate Division of the DRI, the event had another record breaking year, attracting more than 1,200 guests. The gala honored Edward Piccinich (center), executive vice president of SL Green Realty Corp, who received the prestigious Empire Ball Award from last year’s honoree, David Arena (left) of Grubb & Ellis. (Also pictured is Marc Holliday , CEO of SL Green Realty Corp.) The Camillo Ricordi Humanitarian Award was presented to John Catsimatidis , chairman and CEO of Red Apple Group, Gristedes Supermarkets, by last year's recipient, Arthur Skelskie of Moody’s Corporation. The annual DRI film was emceed by Patti LaBelle , and the evening’s entertain - ment was provided by the Ric Mango orchestra and the Mid Life Crisis band. What’s Cooking?

Glen Cove Mayor Ralph V. Suozzi and Judge Richard McCord were among the guests of the fifth annual Cooking for a Cure dinner prepared by Page One Restaurant’s co-owner and chef, Jeanine DiMenna . Held at and sponsored in part by Page One , this exquisite dinner raised $45,000, which included a gen - erous $25,000 grant secured by Senator Carl Marcellino . The event honored Jean Corrigan RN, CDE (2nd from left), director of the Pediatric Diabetes Program at Winthrop University Hospital. Also pictured (l-r) are Co-chair and DRIF Long Island Regional Board member Delia Whitton , Long Island Regional Board Chairman Allan L. Pashcow , Co-chair Mary Hall , and Long Island Regional Director Anthony E. Childs . Shooting for a Cure

Featuring an exciting day of clay shooting, the third annual Sportsmen for Charity (SFC) event was held on April 18 at the Pawling Mountain Club in Pawling, NY. Event Chairman Charles F. Guigno and SFC President Edward A. Rytter thanked approximately 80 guests for their participation during the awards program. Guigno made special mention of his connection to diabetes, as he displayed confidence in the DRI. Guigno is pictured (left) with his grandsons, 10-year-old Joseph , and 17-year-old Michael (right), who was diagnosed with type 1 diabetes at age 11.

UNION EVENTS

Labor of Love

In sunny San Diego, the 23rd annual Labor of Love Golf Tournament brought together nearly 200 mem - bers, friends and business associates of the labor unions at Steele Canyon, one of Southern California’s finest golf clubs. Las Vegas Convention and Visitors Authority sponsored a welcome cocktail party Friday evening at Hotel Del Coronado, and the dinner program Saturday evening was held at this gorgeous Victorian landmark on Coronado Island. Special thanks were extended to Harbaugh Hotels for donating the crystal door prizes once again and to Harrah’s Entertainment for making a $50,000 donation to the event, which raised nearly $200,000. Hosted each year by the Building and Construction Trades Depart - ment (BCTD) of the AFL-CIO and led by President Mark H. Ayers , Labor of Love is an integral part of the Blueprint for Cure campaign, which to date, has raised approximately $40 million for the DRI. Pictured are BCTD Secretary/Treasurer Sean McGarvey (left) and BCTD President Emeritus Ed Sullivan .

15 | EVENTS

NORTHEAST REGION Dare to Dream

DRIF’s Northeast region proudly held its third annual D.R.E.a.M.S. in the City fundraiser on May 14 at Cipriani 23rd Street in New York City. The glamorous and sophisticated event attracted nearly 600 people and generated close to $1 million. Co-chaired by Samantha Shanken , Bonnie Inserra and Risa Pulver , vice chairman for events and public relations of DRIF’s Northeast Board, the unforgettable soirée boasted an Art Deco theme. It featured classic cocktails, plus a delicious dinner paired with highly-rated wines, and luxury silent and live auctions. During the dinner program, Michael Strahan of the -winning New York Giants presented Honoree Thomas P. Silver of Orda Management Corporation with the Dare to Dream award. Pictured with Silver is his wife, Natasha Silver , Honorary Chair.

Riedel Shows it’s All in the Glass

A select group of guests was treated to a unique wine-tasting experience at the beautiful Riedel glass showroom on New York City’s Madison Avenue. Tenth-generation glassmaker Georg Riedel conducted an interactive glass appreciation seminar, during which guests tasted wine in glasses designed for specific types of wine. At the end of the evening, each guest received the set of four beautiful and unique glasses, courtesy of Northeast Board Chairman Ricardo Salmon and his wife, Leslie Dezer, and Northeast Board member Samantha Shanken (center). Attendees were treated to a discussion on advances in diabetes research by DRI’s Dr. Norma S. Kenyon (far right). Also pictured are (l-r) DRI Foundation’s National Board Chairman Emeritus Marc Goodman , National Board Chairman Thomas D. Stern , and President and CEO Robert A. Pearlman.

Katya at Carnegie

Making history as the first female solo pianist to grace the stage of Carnegie Hall for a record ten breathtaking performances, Katya Grineva (pictured) dedicated her tenth performance on April 27 to children afflicted with type 1 diabetes. More than 1,000 concert-goers enjoyed the evening, which featured the works of Chopin, Debussy, Albeniz, and Ravel. Thanks to the generosity of Platinum Sponsor Monste r Worldwide and Gold Sponsor Novo Nordisk, $20,000 of the proceeds from the concert benefited the DRI. World renowned, Katya has shared her musical gift with presidents, dignitaries and the poorest citizens in countries throughout the world.

FLORIDA REGION A Decade of Decadence

At the tenth anniversary of Pleasures of the Palate, hosts Sue (pictured) and Doug Gallagher welcomed approximately 120 fellow bon vivants to the event’s latest venue, Emeril’s Miami Beach. Guests were greeted with glasses of bubbling champagne and passed hors d’oeuvres before sitting down to a four- course dinner paired with the appropriate wines to enhance flavors. Renowned harpist Roberto Perera entertained guests throughout the evening affair, which was presented by Wine Spectator . Exclusive bottles of wine from the cellars of South Florida’s elite collectors were highlighted in the incredible live and silent auctions. Though the wines always take center stage at this event, sharing the spotlight were the perfectly prepared courses served by the impeccable staff at Emeril’s, led by Bryan Kazee (left) and Chef Brandon Benach (right). Third Time’s a Charm

Held at the Metropolitan Pavilion in New York City, the third annual Carnival for a Cure raised more than $500,000 for the DRI while supplying nearly 1,000 guests with a fun, family-friendly afternoon. Party-goers enjoyed various foods and the “way cool” tunes of DJ Scott Zuckerman, plus games and activities galore. Some laughed with stilt walkers, clowns, balloon artists and face painters, while others raced sports cars and dunked hoops. All were delighted with fantastic prizes. Co-chairs Robert and Joanne Schenker are pictured with their sons, Michael (center) and Jamie (right).

CALIFORNIA REGION Fore!

Baseball Great Don Baylor (2nd from left) and Emmy® Award Winning Sports Journalist Roy Firestone joined 200 golf enthusiasts at the Diabetes Research Institute Golf Classic, which was held on May 12 at the El Caballero Country Club in Tarzana. The fourth annual event featured an afternoon of golf followed by auctions and a dinner program that honored Charles Delle Donne (2nd from right), a seasoned veteran of the investment management business. According to Co-chairs Ken Bernstein (left) and Bob Bills (right), the tournament raised $232,000 for the cure-focused work of the DRI. ONLINE AUCTION

Priceless Gift for Son with Diabetes

As the mother of a child with type 1 diabetes, bestselling author Brenda Novak used the creativity and vision she calls upon regularly as a writer to create the 4th Annual Online Auction to Benefit Diabetes Research. Held throughout the month of May in honor of Mother's Day, the auction offered a unique array of items, such as the chance to appear as a character in Novak’s next novel, personal meetings and mentoring from top-notch, celebrated authors, autographed books, evaluation opportunities with some of the most powerful and well- connected agents and editors in publishing, and possibly face-to-face interaction with these A-list publishing industry giants. This year, Novak donated approximately $70,000 to the DRI, the newest beneficiary. Novak is pictured with her 11-year-old son, Thad , who was diagnosed with type 1 diabetes at age 5.

A Family’s Commitment

The fourth annual DRI Golf and Tennis Classic boasted outstanding weather and equally sunny, hopeful spirits at Miami Beach’s prestigious La Gorce Country Club on Monday, January 28. More than 300 friends of Chairfamily Javier (far left), Andria (3rd from left), Matthew (not pictured) , Nicole (right) and Andrew (2nd from left) Holtz , turned out to show their support and encourage - ment for the family’s ongoing efforts to help the DRI find a cure for their youngest member, Andrew. Ever since he was diagnosed with type 1 diabetes seven years ago at age 7, it has become the personal mission of everyone in the Holtz household to do anything possible to eliminate the disease. In accordance with their great efforts, each event, including this one, has raised more than $350,000.

17 | EVENTS

FLORIDA REGION

Dance, Romance and Family Ties

In its 34th year, the Love and Hope Ball truly became a family affair for International Chairmen Linda and Barry Gibb (center) when their children, (l-r) Ashley and Therese , Travis and Stacey, Michael , Ali , and Stephen and Gloria Gibb , were named the first Young Society of Love and Hope Honorees. Other VIPs graciously thanked by Life Chairman Sonja Zuckerman were: Humanitarian Honoree Sherman Simon , Honorary Chairmen Serena and Leon Simkins , Love Honoree Shirley Harris and Hope Honorees Carmen Alexander Printup and Michael Alexander . Golden Beach Police Chief Jim Skinner then presented the key to the town of Golden Beach to Executive Chairmen Sandra and Sid Levy . Themed An Evening of Dance and Romance, the black-tie gala, which hosted more than 500 guests, was held at the Westin Diplomat Resort & Spa on February 16. In combination with the Love and Hope Preview Party in November, the fabulous evening once again raised more than $1 million.

Ladies Shuffle and Shop

More than 220 women gathered to support diabetes research while enjoying an afternoon of card games and boutique shopping at Polo Club of Boca Raton, for the Ninth Annual A Gift of Love…A Gift of Hope Luncheon. Once again led by Mariana Sherman (right) and Renee Aronin (left), the ladies of the Palm Beach County Auxiliary organized the event, which raised more than $30,000, their largest amount yet, for the DRI. If you would like to help out with or attend the next A Gift of Love...A Gift of Hope event, please call the DRI Foundation at 800-321-3437.

Stepping Up to a Cause

Approximately 1,000 students, teachers, and parents, walked, ran, biked and skated to the finish line of the Seven-mile Walk-a-thon. The pinnacle of DRI Week, a week-long campaign that allows participants to organize projects of their choice to create awareness and raise funds for the DRI, the walkathon was held at C.B. Smith Park in Pembroke Pines. This year, it was organized by Charles W. Flanagan High School senior Matt Caesar , who oversaw the work of not only the members of his own National Honor Society (NHS) chapter, of which he serves as the Parliamentarian, but also of all the other participating NHS and National Junior Honor Societies in Broward County. Pictured with Caesar (2nd from left) are classmates (l-r) Jack Garcia , Tony Guadamuz and Keith Brown . DRI Week was also recognized on February 18 with a Majic 102.7 live broadcast with Vance Phillips at the Rand Eye Institute in Pompano Beach.

D'Vine Divas Dish it Out for Diabetes

Serving as a kick-off for the 2008 Food Network South Beach Wine & Food Festival and celebrating the talents of some extraordinary women, the D’Vine Divas dinner was held at the Biltmore Hotel. Female chefs from coast to coast prepared each course, which were paired with incredible wines, courtesy of Southern Wine & Spirits. This fun, feminine and flavorful event also featured live and silent auctions, which bene - fited the DRI. Pictured are Hosts Samantha Shanken (center) of Wine Spectator and Master Sommelier Laura DePasquale (right), with Yvonne Robert of the Biltmore Hotel Cellar Club. Welcome to the Jungle

Jungle Safari intertwined elegance and exuberance to create one of the most memorable events of the area’s famed equestrian season. This decidedly-different gala, held at the International Polo Club Palm Beach on March 1, was topped off with a safari-themed ambience. Aside from the human guest list, which surpassed 300, partygoers were delighted to spend time with a white tiger, a Bengal tiger and a black leopard, as well as a young kangaroo, ring-tailed lemurs and a tiger cub. Chairmen Joe and Ashley Maguire (pictured) were pleased to announce that the event raised more than $225,000. They offered special recognition to their sponsors and committee, as well as to Honorary Chairmen Joan and Lou Jacobs, Chairmen Emeritus Karen and Bob Cavanagh and Vice Chairmen Debbie and Mark Plaxen, Ginny and Paul Farber, and Marie and Michael Bianchini ; and Presenting Sponsor U.S. Trust - Bank of America Private Wealth Management. Seeing Stars

On the heels of another successful fundraising season, members of Love and Hope were thanked for their tireless dedication and support at the committee’s season-closing event, the Thank You Luncheon, held at Miami’s Westview Country Club. Life Chairman Sonja Zuckerman (left) and Executive Chairman Sandra Levy (right) led the program. The coveted Star Award, which is bestowed annually to the person who stands out among the extremely dedicated committee, was then presented to Jill Rosenhaus (2nd from right). The lovely afternoon closed with a serenade by Australian singer and committee member Noeleen Batley Stewart , friend of International Chairmen Linda (2nd from left) and Barry Gibb .

Extinguishing Diabetes

On March 29, South Florida firefighters took a break from fighting fires to help extinguish another menace to their communities, type 1 diabetes. Consisting of firefighters from several local municipalities, the self-named hockey team, East Coast Bomberos, took on Florida’s West Coast Firefighters in an afternoon amateur hockey game played at the Bank Atlantic Center. According to Dade County Firefighter Bob Maloney , event coordinator, the effort raised more than $12,000 for the DRI. Maloney is shown with his niece, Madison Armstrong , and his nephew, Ryan Maloney , both of whom have type 1 diabetes and were his inspiration for the fundraiser.

Fashionably Philanthropic

The Young Society of Love and Hope, in conjunction with Saks Fifth Avenue Bal Harbour, Just Cavalli, and Ocean Drive magazine, hosted a hip fundraiser on April 17 at the prestigious Rubell Family Collection in Miami. Throughout an extended cocktail hour, guests indulged in the delectable hors d’oeuvres of Table 8 South Beach and assorted spirits compliments of Vodka and Southern Wine and Spirits. Randi Caster shared her experiences as a DRI islet transplant patient. Then, the runway came to life, and models captivated the audience with a presentation of the Just Cavalli 2008 Fall Collection. Members of the Young Society of Love and Hope include: Therese Gibb , Jamie Jo Harris , Melanie Herman , Andrea Kasparoff , Erin Newberg , Michelle Rubell , and Nicole Simkins . Shown with DRIF President and CEO Robert A. Pearlman are Rubell (left) and VP and GM of Saks Fifth Avenue Bal Harbour Deborah Slack (right).

19 | For information on the events or to make reservations, CALENDAR please call one of the DRI Foundation offices listed below. Rod Gilbert DRI Golf Classic New York Research Update Love and Hope Preview Party DRI Golf & Tennis Classic August 4, 2008 / LONG ISLAND October 25, 2008 / NEW YORK November 19, 2008 / FLORIDA January 26, 2009 / FLORIDA To be held simultaneously at two This day-long conference at the In its 35th year, this fabulous dinner An afternoon of golf and tennis locations, Pine Hollow Country Marriott Marquis will feature reception, which is often referred tournaments at La Gorce Country Club and Muttontown Country scientific presentations and to as “the heart of Love and Hope,” Club in Miami Beach will be fol - Club, this event includes an interactive sessions. will officially kick off the group’s lowed by a cocktail reception and afternoon of golf followed by an fundraising season at the awards dinner. awards dinner and silent auction. Stand Up for a Cure Diplomat Country Club. October 26, 2008 / CALIFORNIA Love and Hope Ball Phil Peterson’s Key West Poker Run Drew Carey and the Improv All- Kids Party for a Cure February 7, 2009 / FLORIDA September 19-21, 2008 / FLORIDA Stars will bring down the house November 23, 2008 / FLORIDA To be held at the Westin Diplomat Phil Peterson will once again host during another hilarious night, to To be held at the Miami Hilton Resort & Spa in Hollywood, this his annual motorcycle run that be held at the Millennium Bilt - Downtown, this fun family event extraordinary affair is certain to starts in Miami and finishes in Key more Hotel in Los Angeles. This themed Around the World will delight its guests while com - West for South Florida’s biggest event includes a cocktail feature exciting activities, live memorating 35 years of success biker party weekend of the year. reception, dinner, live and silent entertainment, food, a silent auctions and fabulous prize auction, raffles and more. A Gift of Love...A Gift of Hope Kids Party for a Cure drawings. February 16, 2009 / FLORIDA October 19, 2008 / LONG ISLAND Encore! A Cure! Organized by the ladies of the This afternoon of fun for the Diabetes Research Institute January 18, 2009 / FLORIDA Palm Beach Auxiliary, this tenth entire family at Dave and Buster’s Harold Kart Golf Classic Attendees will experience a special annual event will feature a delightful will feature video games, inflata bles, November 17, 2008 / FLORIDA showing of the World Premier of lunch, a unique boutique filled face painting and more fol lowed by An afternoon of golf followed by Miami Bombshells, The Musical , at with fashionable items, a raffle, dinner and a silent auction. a cocktail reception and awards Actors Playhouse on the Miracle Mile and an afternoon of card-playing dinner will take place at Boca in Coral Gables after enjoying a light at The Polo Club in Boca Raton. West Country Club. dinner , wine reception and auction.

is a publication of the Diabetes Research Institute Foundation. DRI focus Summer 2008 / Volume 36, Issue 1

Staff Photography The Diabetes Research Institute Foundation supports the Diabetes Research Institute at the University of Miami Leonard M. Miller School of Medicine, Lori Weintraub, APR Andre Chow whose mission is to develop and rapidly apply the most promising research to treat and cure those now living with diabetes. To obtain additional Lauren Schreier Charles Eshelman information or request copies of DRIfocus, please call (800) 321-3437 or e-mail [email protected] , or visit www.diabetesresearch.org. Natasha Norris Fifth Avenue Digital Laurie Cummings Orlando Garcia DIABETES RESEARCH INSTITUTE FOUNDATION Contributors Dennis Goldensohn Jeanne Antol Krull Marc Levine Erica Banyon Tony Lopez National Office Northeast Regional Office Long Island Regional Office California Regional Office Gary Kleiman Lucien Capehart Photography 200 South Park Road, Suite 100 381 Park Avenue South, Suite 11 18 410 Jericho Turnpike, Suite 201 6624 Melrose Avenue Alegre Levy Paul Lester Photography Hollywood, FL 33021 New York, NY 10016 Jericho, NY 11753 Los Angeles, CA 90038 Jill Salter Patty Daniels Town & Country Studio Phone: (954) 964-4040 Phone: (212) 888-2217 Phone: (516) 822-1700 Phone: (323) 857-0080 Jill Shapiro Miller Peter Richardson Fax: (954) 964-7036 Fax: (212) 888-2219 Fax: (516) 822-3570 Fax: (323) 857-1856 Mitra Zehtab, M.D. Sarah Merians Photography & Co. [email protected] [email protected] [email protected] [email protected] John Seberg Design Jon Simon Franz Franc Design Group Inc. Von Kantor Photography & Design Claude Zick

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