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Abbott I-STAT Analyzer 14 Acid-Nitrile Exchange Reaction 356, 357 541 Index a Au core–shell magnetic-plasmonic Abbott i-STAT analyzer 14 composites 466 acid-nitrile exchange reaction 356, 357 Auto ChIP platform 284 adaptive packed-bed microfluidic process optimization 364 b adhesive bonding 127 Bernoulli’s equation 44 affinity-based CTC enrichment -galactosidase (-gal) 289 CTC-Chip 243 BIA-core microfluidic platform 522 CTC-iChip 244–245 bio-MOF capsules 484 CTC subpopulation sorting 247 biomarker proteins 261 GEDI 243–244 Biot number 54 GO chip 246–247 biphasic interfacial MOF synthesis 485 HB-chip 244 blood 313 HTMSU 245–246 Blue Gene/L system 166 NanoVelcro rare cell assays 246 B220 marker 291 OncoBean Chip 246 Bond number/Eötvös number 51 Ag@ZnO composites 459, 460 bonding process 117–119 alternating current (AC) voltammetry Brinkman number 55 213 Brownian diffusion 314 aluminophosphate material 480 amino acids 273 amperometric protocol 216–219 c anisotropic microparticle formation capacitive sensing 195 397 capillary effects 63 anodic bonding 119 capillary electrochromatography ApoStream (ApoCell) 252 (μ-CEC) 223 Applied Biosystems SOLiDTM system capillary number (Ca) 50, 377 301 capped gold nano-slit surface plasmonic aptamer 266 resonance (SPR) sensor 267 Archimedes number 50 carbon monoxide (CO) 367 ascaridole synthesis 362 carbon paste electrode (CPE) 218 atto594-labeled 20-oligmer nucleotide carbon supported composite synthesis 289 461–463 Atwood number 51 carbonylation Sonogashira reaction Au core–shell composites 457, 459 367 Microfluidics: Fundamentals, Devices and Applications, First Edition. Edited by Yujun Song, Daojian Cheng, and Liang Zhao. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA. Published 2018 by Wiley-VCH Verlag GmbH & Co. KGaA. 542 Index carboxylate-based MOFs 481 isolation by size of epithelial tumor casein kinase I 353 cells (ISET) 238 catalytic hydrogenation 366 limitations 253 catechol 213 microfluidic devices 239 catheter-based intravascular drug microfluidic filtration 249–250 delivery microfluidic spiral separation particle hemodynamics 331–332 250–251 tissue heat and mass transfer multiorifice flow fractionation 251 332–333 NanoVelcro rare cell assays 246 CD31 protein 287 OncoBean Chip 246 CdSe/ZnS composite synthesis 456 polydimethylsiloxane 238 Ce-BDC MOF 487 screening for early cancer detection cell-based assays 11–14 238 cell detection 269–272 (SWOG) S0500 clinical trial 239 centrifuge number 51 synthetic DNA/RNA oligonucleotide ceramic based microfluidic devices ligands 241 519 vortex platform 251 CFD-ACE+ software 162 closed DMF systems 179 CFX Expression Language (CEL) 162 clotrimazole amorphous drug 356 CFX software 162–164 Co@Au nanoparticles 434, 436 Chapman–Enskog theory 30 coaxial microfluidic reactors 487 chip-based microfluidic reactor cobalt (Co) nanocrystal synthesis 422, advantages 363 423 for organic synthesis 360–363 coflowing microfluidics 379 chip-based simple programmed coiled tubing microreactor, for organic microfluidic processes synthesis 356–360 (C-SPMPs) 412, 452 color function volume-of-fluid chromatin immunoprecipitation (ChIP) (CF-VOF) method 156 283 compact disc (CD)-based microfluidic circle-to-circle amplification (C2CA) device 10 281 complex microparticle formation 380 circulating tumor cells (CTCs) composites CellSearch platform 238 description 445 CTC-chip 243 formation mechanism 445, 451–452 CTC-iChip 244–245 preparation, see microfluidic process CTC subpopulation sorting 247 composites computational fluid-particle deterministic lateral displacement dynamics (CF-PD) 319 250 computational fluid dynamics (CFD) dielectrophoresis and 160–161 acoustophoresis 251–252 computational microfluidics 528 epithelial to mesenchymal transition ferrofluid dynamics 315 241 flow through porous media 316–317 GEDI 243–244 fluid–particle dynamics modeling GO chip 246–247 313–315 herringbone chip 244 fluid–structure interaction 317–318 HTMSU 245–246 governing equations 312 Index 543 intravascular drug delivery, see dielectric–plasmonic composites, intravascular drug delivery synthesis of 457–459 model closure 312–313 dielectrophoresis (DEP) 183 nonspherical particle dynamics 316 dielectrophoresis and acoustophoresis pulmonary drug delivery, see 251–252 pulmonary drug delivery diethy-laminosulfur trifluorid (DAST) turbulence modeling 313 360 ComsolMultiphysics 229 digital microfluidic (DMF) system 5 conductivity protocol 221–223 approach 213 conservative level set (C-LS) method analytical models 184 156 chemical and biological applications contact angle saturation 183 199–201 continuous flow reactors 405 chip fabrication techniques continuous/laminar flow 421 179–181 continuum method (CM) 155–158 controlling and addressing the signals coprecipitation method 406 197–198 core alloying and shell gradient doping different electrode configurations strategy 414 181–183 core–shell magnetic nanomaterial, droplet metering and dispensing synthesis of 414–415 techniques 188–189 CoSm alloy nanocrystals, IRCPM droplet routing algorithms 195 process 423 droplet sensing techniques 195, 196 Couette flow 22 effect of the gap height 189–190 C-reactive protein (CRP) 218 electrical signals 185–188 CTC-chip 243 electromechanical and energy CTC-iChip 244–245 based models 183 cytochrome P450 gene 283 feedback control 192–195 numerical models 184 prospects of portability 199, 200 d types 177–179 D-amino acids 273 digital polymerase chain reaction Damköhler number (Da) 49 (digital-PCR) 296 Deborah number 52 2,3-dihydroxybenzoic acid 219 de Broglie thermal wavelength 150 2,5-dihydroxybenzoic acid 219 dense discrete phase model (DDPM) dimensionless numbers 377 314 dimethylitaconate hydrogenation 364 DEP field-flow fractionation (DEPFFF) dinitro-herbicide, synthesis of 362 device 252 direct drug delivery 335–338, 529 deterministic lateral displacement direct simulation Monte Carlo method (DLD) 250 (DSMC) 151–153 dextran-coated superparamagnetic iron direct tumor-targeting methodology oxide (SPIO) NPs 409 332 diamond-shaped microfluidic discrete element method (DEM) 314 aggregation chamber 155 dissipative particle dynamics (DPD) dicarboxylate MIL-88B(Fe) 153–155 crystallization, segmented flow macroscopic hydrodynamic equations synthesis 482 154 544 Index d-leucine (d-Leu) 273, 275 solid–fluid interface 77, 79 d-methionine (d-Met) 273, 275 time scale 80 DNA assays 6–9 water and aqueous electrolytic dried blood spot analysis 201 solution 78 dripping 378 electromechanical and energy-based DropBot 195 models 183 droplet and ionic liquid assisted electrowetting manipulation 11 microfluidic (DIM) synthesis electrowetting-on-dielectric (EWOD) method 480 principle 5 droplet based microreactors, magnetic enhanced condensational growth (ECG) iron oxide based nanomaterial aerosol delivery method 326 synthesis 408 enhanced deeper lung delivery of drug droplet metering and dispensing aerosols via condensational techniques 188–189 growth 326 droplet routing algorithms 195 Entamoeba histolytica antigen droplet sensing techniques 195, 196 EHI_115350 262 drug–aerosol dynamics 322–323 enzyme immunoassays 214 dry etching method 117 enzyme-linked immunosorbent assay dry powder inhaler (DPI) 319 (ELISA) platform 261 epidermal growth factor receptor (EGFR) 286 e Euler–Euler approach 314 Eckert number 55 Euler–Lagrange approach 314 E. coli lac-Z gene expression pattern Euler number 52 289 Ekman number 52 electrical signals, DMF f effect of changing frequency fabrication process techniques 187–188 3D printing technology 114 types of signals 185–186 semiconductor integrated circuits electrochemical analysis (IC)/MEMS fabrication 113 amperometric protocol 216–219 FactChecker CTC capture system conductivity protocol 221–223 (Circulogix) 249 microjet electrode 224–225 Faradaic and non-Faradaic current multiplexed microchannels 225 212 numerical models 226–229 (FDA)-approved clinical microdialysis potentiometric protocol 219–220 probes 272 rotating microdroplet 223–224 ferrofluid dynamics 315 voltammetric analysis 212–215 FeSn NPs 429 electrode design 181 Fick’s laws 29 electrokinetic methods field-programmable gate array (FPGA) electroosmosis flows 76 193 external-operated electric field 79 flash vacuum pyrolysis (FVP) protocols Helmholtz–Smoluchowski formula 357 79 flow regime, in microfluidics induced-charge electrokinetic (ICEK) coflowing microfluidics 379 flows 80 dimensionless numbers 377 Index 545 flow-focusing microfluidics sharp-edged 427 378–379 optical absorbance spectra 427 T-junction microfluidics 377–378 Graetz number 52 flow through porous media 316–317 graft polymers FLOW-3D software 165–166, 184 biofunctional coatings 140 flow-focusing microfluidics 378 grafting-to technique 142 FLOW-VU 164 SI-ATRP 137–142 fluctuation–dissipation theorem 154 surface photo-grafting Fluidigm dynamic arrays 300, 301 polymerization 135–137 fluid particles (FP) 153 graphene-polyaniline (G-PANI) fluid–particle dynamics modeling nanocomposite solution 218 313–315 Grashof number (Gr) 52 fluid–structure interaction green fluorescent protein (GFP) reporter 317–318 284 fluorescent enzymatic assay 11 Gr-1 marker 291 formyl-tetrahydrofolatesynthetase (FTHFS) 296 Fourier number 55 h Fourier transform (FT) algorithm Hagen number 53 213 Hagen–Poiseuille relationship 45 front-tracking (FT) method 156 Hall effect 38 Froude number 50 haplotyping 293 herringbone (HB)-chip 244 high resolution pumping technology g 521 Galileo number 52 high throughput ChIP (HTChIP) device γ-Fe2O3 composites 453, 454 284 gas–liquid reaction 365 high-throughput microsampling unit gas separation testing 497 (HTMSU) 245–246 Gauss divergence theorem 156 high-T/p aminolysis reactions, for gene expression
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