Web Appendix 2

BTS Bronchiectasis Guideline literature searches

Sources to be searched; Database of Systematic Reviews (CDSR) Database of Abstracts of Reviews of Effects (DARE) Health Technology Assessment Database (HTA) Cochrane Central Register of Controlled Trials (CENTRAL) MEDLINE and MEDLINE In-Process Date range searched: all years All study types English language studies only

Cochrane Library (includes CDSR, DARE, HTA and CENTRAL) http://www.thecochranelibrary.com Searched online 26/11/13 Strategy saved as: bts bronchiectasis

#1 MeSH descriptor: [Bronchiectasis] explode all trees (160) #2 bronchiecta*:ti,ab,kw (Word variations have been searched) (421) #3 #1 OR #2 (424)

Of 424 total results in entire Cochrane Library 26 were from Cochrane Database of Systematic Reviews (CDSR), 6 from Database of Reviews of Effects (DARE), 2 from Health Technology Assessment Database (HTA) and 388 from Cochrane Central Register of Controlled Trials (CENTRAL). All results saved to Endnote library marked ‘CDSR/DARE/HTA/CENTRAL 04/06/14 in Custom 4 field as appropriate.

MEDLINE and MEDLINE In-Process Searched 04/06/14 via OVID interface Strategy saved as: BTS bronchiectasis final Database: Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R) <1946 to Present>

1 *bronchiectasis/ or bronchiectasis.ti. (4592) 2 limit 1 to english language (2645)

2645 total results saved to Endnote library marked ‘MEDLINE & MEDLINE In-Process 04/06/14 in Custom 4.

EMBASE Searched 04/06/14 via OVID interface Strategy saved as: BTS bronchiectasis final embase EMBASE 1974 to 2014 June 3

1 *bronchiectasis/ or bronchiecta$.ti. (5726) 2 limit 1 to (english language and embase) (2198)

2198 total results saved to Endnote library marked ‘EMBASE 06/04/14 in Custom 4. Total Results

Database Results After deduplication Custom 4 field Cochrane Database 26 26 CDSR 06/04/14 of Systematic Reviews Database of 6 6 DARE 06/04/14 Abstracts of Reviews of Effects Health Technology 2 2 HTA 06/04/14 Assessment Database MEDLINE and 2645 2566 MEDLINE 06/04/14 MEDLINE In- Process EMBASE 2198 1021 EMBASE 06/04/14 Cochrane Central 388 227 CENTRAL 06/04/14 Register of Controlled Trials Total 5265 3848

All results saved to compressed Endnote library ‘BTS bronchiectasis guideline 2014.enlx’

BTS Bronchiectasis Guideline 2016 searches

Sources to be searched; Cochrane Database of Systematic Reviews (CDSR) Database of Abstracts of Reviews of Effects (DARE) Health Technology Assessment Database (HTA) Cochrane Central Register of Controlled Trials (CENTRAL) MEDLINE and MEDLINE In-Process EMBASE PubMed

Date range searched: all years All study types English language studies only

To deduplicate results against previous results found from searches carried out in 2014.

Cochrane Library (includes CDSR, DARE, HTA and CENTRAL) via http://www.thecochranelibrary.com Searched on 25/04/2016 CDSR: Issue 4 of 12, April 2016 DARE: Issue 2 of 4, April 2015 HTA: Issue 2 of 4, April 2015 CENTRAL: Issue 3 of 12, March 2016

#1 MeSH descriptor: [Bronchiectasis] explode all trees 184 #2 bronchiecta*:ti,ab,kw 548 #3 #1 or #2 554

Of 554 total results in from Cochrane Library 28 were from Cochrane Database of Systematic Reviews (CDSR), 9 from Database of Reviews of Effects (DARE), 2 from Health Technology Assessment Database (HTA) and 512 from Cochrane Central Register of Controlled Trials (CENTRAL).

MEDLINE and MEDLINE In-Process & Other Non-Indexed Citations via Ovid http://ovidsp.ovid.com/ Searched on 25/04/2016 1946-present

1 *Bronchiectasis/ (4815) 2 bronchiecta$.ti. (3525) 3 1 or 2 (5187) 4 limit 3 to english language (3073)

3073 results were retrieved.

EMBASE Searched 04/06/14 via OVID interface 1974 – 2016 April 22

1 *bronchiectasis/ (6455) 2 bronchiecta$.ti. (4313) 3 1 or 2 (6765) 4 limit 3 to english language (4011)

4011 results were retrieved.

PubMed http://www.ncbi.nlm.nih.gov/pubmed/ Searched on 25/04/2016

(((pubstatusaheadofprint OR publisher[sb] OR pubmednotmedline[sb]))) AND (("Bronchiectasis"[Majr]) OR bronchiecta*[Title])

238 results were retrieved.

Total Results

Database Results After Custom 4 field deduplication MEDLINE & MEDLINE in process 3073 433 UPDATE MEDLINE & in process Ovid 25/04/2016 EMBASE 4011 503 UPDATE EMBASE 25/04/2016 Ovid

CENTRAL 512 52 UPDATE CENTRAL 25/04/2016 Wiley

PubMed 238 23 UPDATE PubMed 25/04/2016

CDSR 28 9 UPDATE CDSR 25/04/2016 Wiley

DARE 9 2 UPDATE DARE 25/04/2016 Wiley

HTA 2 1 UPDATE HTA 25/04/2016 Wiley

total 7873 1023

1023 results saved to compressed EndNote library ‘BTS bronchiectasis update 2016.enlx’