Established in 1970 by SSummeru m m e r 220070 0 7 Trinity College ccatalystatalyst CAMBRIDGE SCIENCE PARK NEWSLETTER

In this issue: > Online media distribution from CacheLogic > Q&A with CSR > Quantum cryptography at Research Europe > Lab21 and personalised healthcare > NanoCentral and the small world of nanomaterials > Cambridge Enterprise goes limited > Viewpoint from Dr Jeremy Fairbrother Foreword/New Arrivals

Foreword: Rory Landman, Senior Bursar, Trinity College

I’m very pleased to introduce myself as the new Senior Bursar at Trinity College. Helping to ensure the continuing success of Cambridge Science Park is one of my key responsibilities, and it’s a challenge I will enjoy.

In fact my relationship with Cambridge Science Park goes back to 1985, when as an accountant with KPMG I conducted a review of financing for Small to Medium-sized Enterprises which focused on a number of companies working on the Park at that time. Since then, my career has included working in venture capital in the UK and in Eastern Europe and investing in technology-based companies in South Korea, Taiwan, Israel and India, but I’ve always kept a strategic eye on what’s been happening in the hi-tech sector here in Cambridge.

I believe that maintaining the status of Cambridge Science Park as a leading centre for scientific development and excellence will result from a co-operative approach between Trinity College and our many different tenants – an approach that brings benefit to all sides. I look forward to meeting and working with you in the near future.

New arrivals – Cambridge Science Park Innovation Centre

Sentinel Oncology Sentinel Oncology is a drug discovery company developing a pipeline of small molecules that are designed to selectively target specific features inherent in human tumours. It has no laboratory premises on Cambridge Science Park; instead it outsources R&D from its offices and manages the drug discovery process efficiently. Its goal is to develop a pipeline of novel small molecules and deliver their first pre-clinical candidates during 2007. www.sentineloncology.com

OptiSynx With technologies as diverse as mobile phones, wireless Internet, in-car sat-nav and computer systems for stock exchanges all requiring increasingly accurate time sources, OptiSynx offers the only alternative to the caesium atomic clock or the rubidium+GPS clock. The former is too expensive to be commercial, while the latter takes the control of the most fundamental component of a network out of the hands of its operator. OptiSynx has no such problems. Its advantages include being lower initial cost together with much lower cost of ownership, long lifetime, solid-state, small, low-power, robust and auditable. www.optisynx.com

NanoCentral NanoCentral launched in November 2006 as part of the MNT Facilities Programme (www.nanocentral.eu). Working with companies such as Johnson Matthey, QinetiQ and ICI, NanoCentral provides leading-edge technologies relevant to the development of nanomaterials-based products. These technologies, spanning nanomaterial synthesis, functionalisation, application development, characterisation and SHE, are available to UK research companies on an open-access basis. The provision of these facilities will lower entry barriers and risk for UK companies to evaluate market opportunities offered by nanomaterials www.nanocentral.eu

2 catalyst summer 2007 NanoCentral Networking for a nano world NanoCentral and the growing business of nanomaterials

NanoCentral is a new organisation working of carbon mixed with rubber to make them partnerships with a wide range of organisations to unlock the commercial potential of last longer – without really knowing why. and businesses working with nanomaterials so nanomaterials across the UK business and that others who are new to this field can find industry sectors. At its new office on Cambridge The huge advances made in all fields of science the expertise they need through us.” Science Park, Catalyst spoke to Business in the 20th and 21st centuries have resulted Development Director Dr Dan Gooding about in a much greater understanding of the “In the UK, we’re in danger NanoCentral’s aims and ambitions. properties of nanomaterials, and the resulting of lagging behind parts opportunities for their commercial application of Europe and the US “We’re basically here to help UK businesses are vast. Already they are being used to in the commercialisation understand how nanomaterials might add create new forms of computer memory nanomaterials” value to their product or service offering and and electronic circuits, new types of fabrics, to help them find the most effective way of packaging and materials, innovative optical Through grants to companies and institutions achieving this,” explains Dr Gooding at the and medical devices, solar energy generators such as Johnson Matthey, QinetiQ, ICI and Cambridge Science Park Innovation Centre. and much more. Nevertheless, there are still the University of Liverpool, NanoCentral is significant challenges ahead. helping to drive forward research into the Understanding nanomaterials – the broad commercialisation of nanomaterials – the name for materials designed with dimensions “Businesses that are new to results of which will be shared with other of less than one micrometre (one-millionth of this field can find the expertise interested parties on an “open-access” basis. a metre) – is, in a very general sense, about they need through us” Through its diverse network of service “In the UK, providers, NanoCentral hopes to act as we’re in danger a single point of access for a full range of of lagging services including nanomaterials synthesis, behind parts of formulation, application, characterisation and Europe and the the safety, health and environmental issues US in terms of related to nanomaterials. It also recently exploiting this hosted NanoMaterials 07, Europe's first annual technology for conference on the commercialisation of commercial nanomaterials held at The Sage Gateshead in benefit, which Newcastle. is the main reason behind Having moved into its regional office for the the creation of South East on Cambridge Science Park in NanoCentral,” March 2007, Dr Gooding is keen to work with says Dr businesses here on his doorstep. “Cambridge Gooding. “While is obviously a hi-tech hotspot and there is the science of real potential for nanomaterials to add value nanomaterials to companies working in biotechnology, moves forward inkjet technology, hi-tech device manufacture, Above: ink dye dispersing in water fairly rapidly, electronics and more. I’m looking forward there has been a much slower take-up in to finding out more about some of these expecting the unexpected. At this tiny scale, terms of applying these technologies for companies and how NanoCentral may be able the properties of well-known substances commercial benefit – we’re looking to help to help them.” change to reveal unusual qualities: insulators bridge this gap.” such as plastics become conductors with the www.nanocentral.eu addition of a small quantity of nanomaterial; Supported by the Department of Trade and opaque materials like titanium dioxide turn Industry and regional development agency Companies interested in finding transparent; and stable materials such as iron One NorthEast, NanoCentral opened out more about the potential become combustible. its headquarters at Wilton in Teesside in benefits nanomaterials could bring September 2006, an area renowned for its to their business can contact In fact, making use of the strange properties process engineering and chemical industries. Dr Dan Gooding, Business of nanomaterials for human benefit is nothing Nevertheless, it is focused on a UK-wide Development Director for new: a bright red colouring in church windows approach that is aimed at creating a national NanoCentral. was achieved by artists in the middle ages network of expertise and opportunities. Office: 01223 437067 through the use of gold nanoparticles, which Mobile: 07833611206 change colour at a microscopic size. In the “We operate on a hub-and-spoke model,” Email: [email protected] 1920s, tyre manufacturers used nanoparticles explains Dr Gooding, “establishing links and

catalyst summer 2007 3 CSR leads the way Innovation is key for wireless giant CSR is the leading global provider of personal earlier this year, we demonstrated our GPS BlueVOX QFN will open up major new wireless technology; its product portfolio covers E5000 product (based around BlueCore) at markets for consumer electronics, allowing Bluetooth, GPS, FM receivers and WiFi and in 3GSM in February. This solution is available ODMs/OEMs to create sophisticated 2006 it achieved revenue of $705m. Catalyst now. Bluetooth headsets for mass volume markets spoke to Alan Woolhouse, VP Communications, in both mature and developing economies. about the way forward for this Cambridge Can you outline your goals for this The design is equally efficient as a platform for success story. market sector? headset products for VoIP markets. CSR’s recent acquisitions fall naturally into You’ve achieved a market share of our strategy of innovation and product Below: CSR’s Bluetooth technology more than 50% in all Bluetooth market development. By applying our patented segments – what have been the key methods to reduce both the number of elements in achieving this? processor cycles and the time to first fix, Innovation has been a vital factor in CSR’s CSR can provide an extremely power- impressive Bluetooth market share. CSR efficient overall solution with less than half pioneered single silicon chip Bluetooth (with the processing requirements of alternative integral radio transmitter, microprocessor and solutions, whilst remaining flexible enough to baseband) at a time when our competitors perform highly dynamic and accurate tracking. were still producing two- and three-chip CSR has removed the barriers for mobile solutions. This gave us an innovative and handset makers and operators to provide competitive advantage. Product development location-based services for the mass market is key, and CSR is now on its fifth generation on products such as low- and medium-end of Bluetooth – all of which provide solutions feature cellular handsets, Smartphones, PNDs, for all kinds of wireless applications. CSR is and other portable devices. adept at finding and exploiting new ways of using Bluetooth (for instance wireless Can the system be made to work controllers for games consoles, such as Sony’s indoors? Are handset manufacturers PS3). CSR’s Bluetooth products are smaller, likely to take it up? use less power and cost less. CSR is combining its software-based GPS solution with cellular location technology and You say that “we expect new waves of RF IC know-how to deliver a new generation applications to be developed outside solution for 2G/3G handsets, which will also of the original core applications of provide fast location fixes indoors. ABI predicts mobile phones (Bluetooth) and PC that by the end of 2008, 25% of WCDMA connectivity (802.11)” – can you tell handsets will have GPS capabilities; this is me about some of these? clearly a growing market. Mobile phones and headsets have been core to Bluetooth’s take-up by consumers. Now What are the key features and that more than one billion Bluetooth products advantages of the new BlueVOX QFN have been sold and we’re all more at ease chip? You talk about the need to “increase with the technology, new media are being software content in new products” BlueVOX QFN achieves a new low in power found. CSR is already leading the way with – why is this? consumption and bill of materials (eBOM) for new applications, with Bluetooth and WiFi in headset design. The example design offers CSR believes that increased software products such as gaming, automotive, music talk times of up to 11 hours from a small, content improves the robustness, flexibility, players, PCs, cameras and satellite navigation lightweight battery, and the eBOM (including performance and functionality of its solutions systems. As CSR has expertise in Bluetooth, a lithium battery) is less than $6 in production and helps to distinguish them from competing WiFi, UWB (makes Bluetooth faster), VoIP, volumes. Call clarity and range is superb, the offerings. CSR aims to continue to develop GPS, Wibree (developed by Nokia), we are technology eliminates annoying pops and clicks tools to allow its OEM and ODM customers able to provide our customers with the ideal in long-range and difficult radio environments. to develop their own applications software. solution for their particular needs. In recent This, together with CSR’s embedded software, months CSR technology has appeared inside will enable them and their customers to create The design is based on a QFN-packaged products from Sony, Motorola, Samsung, Sony highly featured and differentiated products. BlueCore chip, and a low-cost two-layer Ericsson, TomTom and more. PCB. CSR's new design is complete and interoperability-tested, yet still highly software- You’re looking at combining a GPS and configurable. User-configurable features include Bluetooth chip – when can we expect the functionality of button presses, LED to see this on the market? flashing, pairing operation, etc. After our acquisitions of CPS and Nordnav

4 catalyst summer 2007 CSR

One of your stated aims is to lower we put FM radio on the chip and we’re now applications, provides a substantial medium- the cost of IC solutions – how are you helping customers incorporate GPS technology term opportunity for CSR. CSR’s single chip, going to achieve this? in their devices. RF and software design expertise, combined In our industry, cost is closely associated with with its knowledge of the integration of size. Essentially, our costs are lower because It’s recently been announced that John wireless solutions with its customers' products, we generate more chips from a wafer, driving Whybrow will stand down as chairman puts the company in a favourable position greater value from our investment. The size of of the company – a position he has held to pursue such future opportunities. CSR’s since March 2004. Can core strength remains in Bluetooth, and you summarise some of we believe that the market will increase in his achievements? strength through the global growth in mobile John has been an excellent telephony. Our ability to offer handset leader of the board and manufacturers increased functionality on a has successfully overseen a single chip will be the cornerstone of CSR’s sustained period of growth future success. In addition, recent acquisitions for the company. During his (of Nordnav and CPS) secure our position in tenure, CSR has grown from GPS technology and underpin our desire to a company with revenues of incorporate location-finder technology on the $68m to one with a 2006 chip at a price far lower than that currently on revenue figure of $705m. The offer. company is no longer a small business, but a major player What has been the importance for in the technology sector with CSR of being located on Cambridge expertise that has broadened Science Park? out from Bluetooth into CSR established itself in the Cambridge WiFi and now GPS, and has Science Park in 1999 after founders Phil customers all over the world. O'Donovan, Glenn Collinson and James Collier split from Cambridge Consultants What are the key to set the company up. The location is challenges ahead for attractive in that it boasts extensive facilities the new chairman Ron and has offered companies such as CSR Mackintosh? comprehensive support from the ever-growing Continuity and knowledge research and development community. As the of the sector in which centre of , the Cambridge Science CSR operates were key Park is clearly at the heart of technology considerations in identifying innovation and is a focal point for world-class a suitable replacement. The design and engineering talent. CSR now also board had due regard for Mr has offices on the Cambridge Business Park Mackintosh’s independence – Churchill House. chip is the single biggest determinant of cost, and considerable experience in both senior and we design smaller. Secondly, we integrate executive and non-executive capabilities in www.csr.com as many technologies as possible onto the chip international technology companies, as well as in order to provide greater design freedom his knowledge of CSR where he has been a and make it less expensive for customers to director since May 2004. The key challenge for design and build around our products. Finally, Ron will be to maintain the high standard that because CSR chips provide more reliable has been set before him. connections, we can deliver lower lifetime costs to manufacturers. Annual revenues grew by 45% in Size matters. With consumers demanding 2006 – can you hope to maintain this greater capability from smaller devices, size is a impressive level of growth? critical commercial battleground – particularly CSR believes strong growth in the Bluetooth in sectors such as headsets and handsets. CSR market will continue in 2007, and will spread is the industry’s pioneer, the first company to beyond the cellular sector into applications integrate all wireless technology on a single including PCs, gaming, music and automotive. chip, and our current target is to reduce the The evolution of existing standards, and size of a thin die from 670 micrometres to the introduction of new ones with differing a maximum of 400 micrometres. In 2006, performance characteristics to enable new

catalyst summer 2007 5 Getting personal Lab21 and the changing approaches to healthca

The realisation of a new era of truly personalised US healthcare system some $20bn per year; An increased focus on diagnostic testing both medicine is the vision that drives the team at in the UK, this figure is around £600m per during the drug discovery phase and as an Lab21. Catalyst spoke to Chief Scientific Officer year. So governments are beginning to realise integral part of patient management is the Dr Berwyn Clarke to find out more. that they can save lots of money if they context in which Lab 21 has developed its manage drug treatments better; tailoring drug broad range of services. treatments more closely towards the individual Drugs tailored to individual patients and a patient is more cost effective than not healthcare system more effectively focused “In the US and to some extent in Asia, the doing so. In the US, the Secretary of Health on individual needs is no pipe dream and Human Services has recently identified shift towards more personalised medicine – governments and pharmaceutical companies personalised healthcare as a top priority for has led to the development of some very are both working towards a shared goal. But the health system, with the intention to deliver sophisticated, high-throughput molecular this shift in approach in healthcare provision the right treatment to the right patient at the reference laboratories. That model has never cannot be achieved without the provision of right time – every time.” been developed as such in Europe because of high-quality diagnostic testing services – a field state healthcare providers such as the NHS, in which Lab21 is pioneering the way. The development of personalised medicine which tend to have much smaller localised is also becoming increasingly important in testing centres. So we believe Lab21 meets “This business is about the simple but very the drug discovery process, with a shift away a real market need for high-quality diagnostic important fact that everybody is different from the ‘one-size-fits-all’ approach that has testing across a wide range of different and that therapies are therefore much more previously dominated. Regulatory bodies conditions.” effective if they are targeted towards an are now asking drug companies undertaking individual’s specific needs,” explains Dr Clarke. clinical trials to provide more details relating “Lab21 meets a real market “A person may have a particular condition and to both patients who respond and patients need for high-quality diagnostic testing across a wide range of different conditions”

The company was founded in 2005 through the merger of clinical diagnostic experts Oneida TheraDiagnostics and MTI, which provides environmental testing services. Helping to broaden its service offering and as part of an ambitious growth strategy, Lab21 recently acquired Newmarket Laboratories. Providing low-cost immuno assays for major infectious diseases such as malaria or tuberculosis, the acquisition makes Lab21 the biggest global supplier of syphilis screening reagents to blood banks.

Lab21 has built a strong portfolio of services through licensing agreements to test for a wide variety of conditions including predisposition to cardiovascular disease, genetic predisposition to specific forms of breast, colorectal and skin cancer, and non- there may be a well-established treatment for who don’t, with a view to establishing a more invasive assessment of liver health. this condition, but if you give a certain patient personalised approach. the wrong dose at the wrong time, you can “At the moment, our area of specialism is end up with some pretty severe problems “Some drugs are now only getting licensed virology, although we are evolving slowly into – including death.” when accompanied by a diagnostic assay cancer as well,” explains Dr Clarke. “Our initial which determines whether a patient fits a focus on virology is a result of the experience “In the US, for example, Adverse Drug- specific profile,” comments Dr Clarke. “The of the people who founded the company and Related Events – where a patient responds use of Herceptin only for women with breast also the fact that personalised medicine has badly to a particular treatment – are the cancer who meet a certain profile is the best- been much more advanced in treating viruses fourth leading cause of death. They cost the known example of this approach.” than in other areas of medicine. Because we

6 catalyst summer 2007 Lab21

hes to healthcare provision

work with viruses, we have a very high-quality geographical areas,” containment facility in this building which means says Dr Clarke. “We’re we can conduct tests for dangerous pathogens looking to expand into such as HIV and viral hepatitis.” North America and into other parts of the “The things we do are world – we want to be relevant to almost any drug able to carry out the company that’s developing a same tests in different pharmaceutical” areas with the same quality, uniformity In March 2007, Lab21 launched a and consistency. We revolutionary new assay able to detect any think we can cover virus from a panel of 20 distinct respiratory Europe from here, but viruses using multiplex detection technology. we certainly want to Testing a nasal swab sample, Lab21 can go into Asia and with determine which, if any, of the respiratory the Chinese market Left, top and below: diagnostic testing with Lab21 viruses is present within six hours – including opening there are a test for avian flu. “The real value of this test massive opportunities.” lies in its ability to identify those respiratory viral infections for which therapeutic intervention is With preparations underway to float the currently available, so hopefully conditions can company on the AIM market on the London be treated quickly and effectively,” adds Stock Exchange, Dr Clarke sees one of the Dr Clarke. most important short-term challenges as increasing awareness among potential clients of The Lab21 group is growing steadily, with a the diverse range of Lab21’s services. team of nearly 25 based at its technical facility on Cambridge Science Park, and a further 20 “The things we do are so relevant to people employed across sites at its Head Office almost any drug company that’s developing and at MTI Diagnostics (both in Fareham, a pharmaceutical or any organisation Hampshire) and at Newmarket Laboratories (in that’s involved in human healthcare, from Newmarket). With the support of its venture basic research and development in the capital partner Merlin Biosciences, the pace of pharmaceutical industry right through to the expansion shows no sign of slowing. clinical management of patients,” he says.

“We’re in a serious acquisition mode to build “It’s great to be here in Cambridge and the company both in terms of bringing in new on Cambridge Science Park with so many technologies and also getting us into new exciting drug discovery companies around us. We hope we can start to interact with many of them and look at how we can add value to their business.”

www.lab-21.com

catalyst summer 2007 7 Ahead of its peers

CacheLogic is a company helping to revolutionise use of peer-to-peer file-sharing applications online media distribution through a radical new such as KaZaA and eDonkey. These approach – Catalyst spoke to Chief Technical applications were consuming in excess of 60% Officer Andrew Parker to find out how. of an ISP’s network and making the supply of broadband services to consumers unprofitable. The dramatic growth in the popularity and capabilities of the Internet has created CacheLogic was first to market with a solution unprecedented opportunities for the shar- to cure this problem. “We came up with ing of information and rich media on a global a very novel solution which was based on basis. However, this growth has also created the idea of installing devices across the ISP’s a new set of challenges for those companies network that would keep temporary copies of the most frequently requested content,” says Andrew. “So if 10,000 people were requesting a download of EastEnders or Top Gear at the same time, only the first person would get it direct from source; the rest would download it from the copy stored in the cache across different points within the ISP’s network. It was a system that dramatically reduced their costs and we went on to sell the platform very successfully to ISPs right across the globe.” “There is already a lot of capacity on the Internet, but you just need to harness it for where and when you want it”

The next major step in the company’s looking to provide the content, such as film, evolution came in 2004 when CacheLogic was music, games or software, that is increasingly in commissioned by the BBC to undertake a six- demand by online users. month study into the use of peer-to-peer file sharing as a means for distributing broadcast Having formed in 2002, CacheLogic was content over the Internet. initially focused on helping Internet Service Providers (ISPs) deal with the network “At that point, companies really had two congestion being created by end-users making mechanisms for distributing their content,”

8 catalyst summer 2007 CacheLogic says Andrew. “They would either host all of it powerful platform. To provide round-the-clock Having been funded to date by venture capital themselves with a large Internet pipe coming support, CacheLogic has established teams in firms 3i, Amadeus and the Cambridge Gateway out of the building or they would use a content Madrid, New York, San Francisco, Los Angeles Fund, the team at CacheLogic is now looking to distribution network, which is typically a large and Singapore which serve its international build on its already impressive foundations. network of servers distributed around the globe client base. that keep temporary copies of the content “There’s no one out there who is doing exactly close to the end-user. “We’ve taken technology and what we are doing, so we believe we can really ideas that have been out in the thrive in our market and become a household “But the problem for television producers public domain for some time name alongside those of our core customers.” such as the BBC was that unlike broadcasting and added security and quality programmes over the air, broadcasting via the of service on top” www.cachelogic.com Internet actually becomes more expensive when more people watch due to the necessity “Because of the global nature of our business, of providing more bandwidth. In this model, it we’re working across different time zones is often cheaper to make and ship a DVD of simultaneously,” says Andrew. “That means a programme or film than it is to broadcast it there is no off-peak or down time when online. we can take our servers offline and make modifications, and we are dealing with our “We realised that there was a great market customers’ most valuable assets, namely their opportunity to create a system that could movie, TV or software content, therefore we distribute content faster and more cost have to guarantee 100% availability of content effectively. What we created was in fact a from our network.” hybrid between a traditional distribution network and a peer-to-peer infrastructure The future certainly looks bright for a company – it’s a system which is scaleable so that as which is helping to meet the ever-increasing your audience grows, so does the amount of demand for high-quality content via the resource you have available for distribution, Internet. “The success of YouTube and Google thereby minimising the cost to the broadcaster videos has been based upon low-bit-rate and making the delivery of TV content over the short-form content, much of which is user Internet a reality. generated,” explains Andrew.

“It’s really based on the understanding that “But an increasing number of manufacturers there is already a lot of capacity on the are producing devices to bridge the PC to Internet, but you just need to harness it for television gap – meaning you can watch content where and when you want it. So our system from your computer on your TV. When this uses a network of computers owned and run by CacheLogic that are distributed across the globe, coupled with a file-sharing system that utilises the resources of the individual users. This means that when demand goes up, users begin to download from each other as well as from our fixed network.

“We’ve taken technology and ideas that have been out in the public domain for some time and added security and quality of service on top. Our download software actually splits the content into small chunks which are then checked for corruption, which means the quality of the end product is guaranteed. But unlike most peer-to-peer systems, ours is a closed network. You can’t publish and share Above and left: CacheLogic’s international control your own files on it; only the content provider centre on Cambridge Science Park is able to distribute via the network. happens, viewers are going to demand a higher picture quality and a Launched in July 2006, the Velocix system is broader catalogue of programmes, which drives already proving a hit with a number of major cost and network impact. Because Velocix can broadcast and media companies, with others help to meet this increase in demand, this trend currently in the process of encoding their video is driving more and more customers in our content or software for distribution via this direction.”

catalyst summer 2007 9 Making the quantum leap Toshiba Research Europe and the cryptography challenge

– such as factorising of very large numbers message into a form that cannot be read – that are virtually intractable using an ordinary except by using a so-called electronic ‘key’, computer. But while the development of which is then used to decrypt the information quantum computers is still some way off, one back into its original form. However, the practical application of quantum information security of this process is compromised by technology is already in use: quantum the possibility of the encryption key being cryptography. obtained and used by a non-intended recipient. In contrast, quantum cryptography “If we encode messages in – more accurately termed Quantum Key individual quantum states, an Distribution (QKD) – uses an automated eavesdropper who tries to method for distributing secret keys using intercept the message cannot standard communication fibres. avoid changing it” “The revolutionary feature of QKD is that “This ultra-secure way of sending messages is it is inherently secure; assuming that the based on the fundamental idea that measuring laws of quantum theory are correct, we a quantum state will, in general, alter it,” says can prove that the key cannot be obtained Dr Shields. “So if we encode messages in by an eavesdropper without the sender’s From its base on Cambridge Science Park, individual quantum states, such as the phase and recipient’s knowledge,” says Dr Shields. Toshiba Research Europe has been helping to of photons passing down an optical fibre, “Furthermore, QKD allows the key to be investigate the potential for quantum theory to an eavesdropper who tries to intercept the changed frequently, reducing the threat revolutionise the world of information technology. message cannot avoid changing it. We can test of key theft or ‘cryptanalysis’, whereby Catalyst spoke to Dr Andrew Shields to find out therefore if the message has been read before an eavesdropper analyses patterns in the more. it reaches the intended recipient – something encrypted messages in order to deduce the that is impossible using classical signals.” secret key.” “Feature sizes in computer chips have been getting smaller and smaller at a rapid pace,” In a world where ever-increasing amounts The development of practical QKD says Dr Shields. “As the length scales halve of information are shared and distributed applications is an ongoing scientific and approximately every 18 months, it is predicted electronically, ensuring the privacy of such engineering challenge, and the Quantum that within the next 10–15 years we will reach information has become a key priority for Information Group at Toshiba Research the limit where single electrons switch our organisations, businesses and governments Europe led by Dr Shields has developed information systems, and as this happens an alike. Research in this field has been pioneered a market-leading solution. The Toshiba understanding of quantum effects becomes by Professor Sir Michael Pepper, who founded Quantum Key Server delivers digital increasingly important.” the Semiconductor Physics Research Group at keys across fibre-optic-based computer the Cavendish Laboratory. Professor Pepper networks, and can be used for a variety of The ultimate limit comes when a ‘bit’ is also Managing Director of the Cambridge cryptographic applications including encryption containing binary information is represented Research Laboratory of Toshiba Research and authentication of sensitive documents, by the quantum state of a single particle, such Europe at Cambridge Science Park, where the messages or transactions. as the polarisation of a photon (the particles Quantum Information Group headed by Dr of light). At this quantum level, a quantum Shields is based. “Our system provides world-leading computer could work with bits that can be performance, including key distribution over both “0” and “1” at the same time, allowing The basis of traditional encryption technology standard telecom fibre links exceeding 100km it to solve certain mathematical problems is the use of an algorithm to scramble a in length,” explains Dr Shields. “Our design has

10 catalyst summer 2007 Toshiba Research Europe p been rigorously proven secure from all types Palma. Nevertheless, there are still significant of eavesdropping attack, meaning that it will be barriers to the adoption of new cryptographic secure not only today, but also in the future.” technologies, as Dr Shields points out.

“Toshiba is keen to establish “A particular problem for QKD is selling further links with companies or technology based on quantum mechanics to organisations with an interest in clients who often know little about physics and the technology” are used to traditional cryptography. Another hurdle is the lack of a security certification With the Toshiba Cambridge Research process for the equipment. Users need Laboratory based on Cambridge Science reassurance not only that QKD is theoretically Park, it was only natural that part of the sound, but also that it has been securely testing for the Quantum Key Server actually implemented by the vendors. It is encouraging took place between different buildings on that there are several initiatives underway to the site. A partnership approach in the field establish common security standards for QKD. has been developed, including research on an international basis within the European “As the market for QKD develops, we can SECOQC consortium, a collaboration of expect that the price of equipment will drop academic and industrial QKD researchers, significantly. Within ten years, we may see QKD cryptographers and telecoms engineers. used not only in corporate and government networks, but also in networks serving home “It’s a fast-moving and very dynamic field to users. be working in, and Toshiba is keen to establish “Optical fibres are already used to deliver further links with companies or organisations television, phone and Internet services to with an interest in the technology and its domestic users in several countries. Although applications,” adds Dr Shields. current QKD systems are too expensive for such applications, they may become viable Progress to date has been exciting, with if miniaturisation to microchip scale and alternatives to using a fibre-optic networks mass production lead to the expected price under development including the sending of reductions. quantum keys over long distance via free-space links to low-orbit communications satellites. In “The days when the products of the quantum- 2006 a collaboration between researchers at information industry serve every household may the universities of Vienna, Munich and Bristol not be too distant.” implemented a free-space link over 144km Below: Toshiba Research Europe’s quantum key between the Spanish islands of Tenerife and La www.toshiba-europe.com/research distribution system

catalyst summer 2007 11 Cambridge University Enterprising company Cambridge Enterprise evolves to improve technology transfer services

a service for academics and students in the the University. We’ve been taking a fresh University, a driver for growth in the UK look at our assets in this area to see if we economy, and ultimately helping to create are managing this equity well, whether it is a better world by enabling innovations and advisable to sell or retain equity, and whether discoveries to become practical marketplace there is additional support we might give such realities. companies to increase their probability of success. “But when push comes to shove, our primary objective is to be trusted business advisors to “Commercialisation arrangements are our academics; they are our primary market another key asset. There are over 250 active and source of innovation. If we can’t provide arrangements – technical licence agreements Above: the team at Cambridge Enterprise a good business resource to them then the with companies who are commercialising other things are not going to happen.” inventions that we own on behalf of the University and the academics. Of these, about Cambridge Enterprise, the University of To achieve this, the 30-strong team 100 are generating revenue. We’ve been Cambridge’s knowledge and technology transfer at Cambridge Enterprise is working to looking at whether these generate sufficient service, has become a limited company. Catalyst understand better its internal audience of levels of revenue; for those that don’t, we’ve spoke to Chief Executive Teri Willey about what academics, in particular through a group of been looking at the reasons why and whether the change means and what the organisation “Enterprise Champions” who form a crucial further investment is needed.” hopes to achieve. link between individual University departments and the Cambridge Enterprise organisation. Prior to becoming a limited company, It’s now nearly three years since the University Cambridge Enterprise was already achieving of Cambridge brought together its Technology “We’ve been asking ourselves some impressive results. In 2005/06, it Transfer Office, consultancy business and seed what our asset pools are and generated £6.26m in revenue from the fund operations to create a single organisation: how well we really understand exploitation of intellectual property and Cambridge Enterprise. Marking a new them” consultancy, distributing in excess of £5.29m milestone in its evolution, on 1 December to academics and University departments and 2006, Cambridge Enterprise became a limited The new limited company is also seeking an additional £565k to the University Chest. company wholly owned by the University and to achieve a renewed commercial It also closed 61 commercialisation deals headed up by Chief Executive Teri Willey. perspective, including what it describes as and filed 58 new patent applications. Teri “an asset-management approach” to growing attributes this performance to the dedicated “Being a limited company helps us in our portfolios which include a growing number team at Cambridge Enterprise who achieved drive to create a more transparent financial of commercialisation contracts and equity this performance during a period of patent structure, which in turn makes it easier to holdings. policy revisions and organisational change. monitor our income and distributions and to Nevertheless, having joined on 1 August 2006, what extent these are helping us to achieve “We’ve been asking ourselves what our asset she is focused on the challenges ahead. our objectives,” explains Teri from the pools are and how well we really understand Cambridge Enterprise offices on Trumpington them,” explains Teri. “Certainly revenue “We need to strike a balance between doing Street. streams from contracts and realisations for good deals that bring resources back to equity are important assets. Our relationships our stakeholders in the University, bringing “We’re here to help to create with academics and students are very resources back into our organisation to a better world by enabling important assets as well, and we’re working operate, and achieving broader aims and innovations and discoveries to hard to get the most out of these. aspirations – helping to create the ‘better become practical marketplace world’ through bringing important Cambridge realities” “Our assets also include a portfolio of over innovations to the public through commercial 350 patent families. Most of those are channels.” “It’s also been an important opportunity to already licensed or under commercialisation refocus our goals, looking at what we want to agreement with companies, but for some achieve and how we are going to achieve it. we are still trying to find the right partner to A business like this is not just about revenue develop them. generation, although that is one of our objectives. We are also tasked with providing “We also have equity in about 60 companies an interface between academia and industry, who are using technology developed at www.enterprise.cam.ac.uk

12 catalyst summer 2007 Go-ahead for redevelopment of Building 101 Exemplar Properties on behalf of Hermes have building that has been undertaken since the commenced the redevelopment of Building late 1980s and reflects strongly improving 101 on Cambridge Science Park. Acting on market conditions." behalf of Exemplar, Bidwells' Planning and Development Teams have secured planning Completion of 101 is due in the summer of permission for a new 80,000 sq ft net office 2008 and the building is available to let either building replacing the dated 1980s building on as a whole or in parts. For further information the site. please contact Jamie Green at Bidwells on 01223 841841. Dick Wise, Head of Commercial Development at Bidwells, said: "It is the largest speculative Right: Artist’s impression of the new Building 101

Xaar collaborates to develop inkjet printed memory applications Industrial inkjet technology leader Xaar has This collaboration is a continuation of TFE’s Applications Technology team, stated that: signed an agreement with the Norwegian and and Xaar’s previous collaboration leading up “As the printed electronics market continues Swedish company Thin Film Electronics (TFE) to the successful development, realisation and to evolve and expand, we see numerous to jointly develop industrial inkjet methods announcement of the world’s first printed opportunities for products that include and processes that can be used for producing ferro-electric memory array at IPEX ’06 held in memory and with that we see a market need printed memory applications efficiently and Birmingham, UK in April 2006. for our inkjet solutions for production of in high volumes suitable for commercial printed electronics products in general.” applications. Werner Zapka, head of Xaar’s Advanced

CSR wins Queen’s Award for Enterprise Below: CSR’s BlueCore™01 Cambridge Silicon Radio (CSR) has won the and we will continue to provide customers renowned Queen’s Award for Enterprise in with the best quality, ready-to-use software the Innovation category in recognition of its solutions and hardware reference designs for successful development of the BlueCore family their products.” of single-chip Bluetooth ICs. CSR previously received the Queen’s Award John Scarisbrick, CEO, commented: “We are for Enterprise: International Trade in 2004 thrilled to have been awarded the UK's most following the success of its initial public offering prestigious honour in business performance for on the London Stock Exchange, the industry's a second time. Our strength is in the delivery biggest UK technology flotation for three of highly integrated wireless systems on silicon, years.

catalyst summer 2007 13 Cambridge Science Festival Cambridge Science Park was proud to be an science through lectures, demonstrations, associate sponsor for the Cambridge Science roadshows and workshops under the theme Festival, which featured a programme of ‘The Big and the Small’. exciting events across the city from 12 to 25 March. Attracting more than 25,000 visitors, the Cambridge Science Festival is the UK’s largest The Festival, now in its 14th year, gave free science event of its kind and included children, young people and adults unique more than 100 events across 40 departments opportunities to share in the excitement of and five sites.

Above: Dr Pete Wothers gave his explosive chemistry lecture

Takeda acquires Paradigm Pharmaceuticals Takeda Pharmaceutical Company, Japan’s Ltd and Takeda Singapore Pte Ltd. largest pharmaceutical company, acquired Paradigm Therapeutics on 29 March 2007. "Takeda have been an excellent partner in our CNS collaboration and this deal represents Founded in 1999 by a logical and positive extension to that. The researchers, Paradigm established world-class company looks forward to continuing with target identification and validation capabilities its drug discovery and development activities based on genetic engineering and in vivo within the global reach and long-term planning pharmacology. Paradigm Therapeutics Ltd and horizons of Takeda," said Alastair Riddell, CEO its subsidiary Paradigm Therapeutics Singapore of Paradigm. Pte Ltd are now renamed Takeda Cambridge www.takeda.com Above: Takeda Cambridge Ltd at Cambridge Science Park

BioProgress launches new tablet technology BioProgress has launched a new tablet counter drugs market such as pain relief and with partners. Speed of onset of action is an technology, FastWrap™, which facilitates the cough/cold therapeutic areas. important weapon in the war against illness rapid disintegration of coated tablets and Richard Trevillion, Chief Executive Officer, and we are now able to compete effectively thereby a faster action onset of a drug. BioProgress, said: "The launch of an additional within the marketplace.” technology within our portfolio is another FastWrap™ uses the company’s TabWrap™ important step in creating a compelling enabling technology platform to create enabling technology range for our own competitive advantages in the over-the- products whilst enhancing our ability to work

14 catalyst summer 2007 PARKLIFE connections

Biology in Business (BiB) is a Cambridge-based non-profit Cambridge AWiSE (Association for Women in organisation with more than 1,700 members that bridges academic Science and Engineering) and commercial life science to promote career development AWiSE is a multi-disciplinary membership organisation composed and technology transfer through events, online resources and of individuals, businesses, associations, institutions and other networking opportunities. organisations, all of whom share the common goal of advancing the interests of women in science, engineering and technology. Email: [email protected] The Cambridge branch holds regular meetings and events; for Web: www.biologyinbusiness.org details see the website or get in touch. Email: [email protected] Web: www.camawise.org.uk The Eastern Region Biotechnology Initiative (ERBI) The Cambridge Network is a membership organisation with ERBI’s objective is to facilitate and accelerate the growth of the mission to link like-minded people from business, finance and biotech in Cambridge and the . Its core activities academia to each other and to global partners for the benefit include: hosting networking events, special interest groups, training, of the Cambridge region. It helps Cambridge raise its game by partnering and member promotion, publications, regional and delivering over 40 networking, partnering and special interest group national initiatives. events per year (mostly in Cambridge, but also in London, Boston Email: [email protected]. and Shanghai) and a high-profile website where its 1,300 corporate Web: www.erbi.co.uk members publish profiles, news, jobs and events every day. Web: www.cambridgenetwork.co.uk Research Services Division (RSD) helps to identify, secure and Tel: 01223 422362 manage research funding for the University from regional, national and international sponsors. It encourages collaboration between the Enterprise Link, a Business Link service for Cambridgeshire, University and industry, and fosters long-term research partnerships is a membership network providing advice and support for early- between companies and academics for mutual benefit. RSD also stage, entrepreneurial/aspirational businesses. It holds a variety of organises Horizon, the leading seminar series, which provides networking events and seminars at the St John’s Innovation Centre participants with a first look at new developments in the most in Cambridge, and also sends out regular bulletins to members exciting areas of science and technology at Cambridge University. with information, advice and opportunities. It can also arrange access to sector specialists. Contact: Jo Ryan Email: [email protected] Email: [email protected] Web: www.enterprise-link.co.uk Web: www.rsd.cam.ac.uk i10 provides large and small businesses with easy access to the The Great Eastern Investment Forum (GEIF) is a expertise, resources and innovation within universities and higher leading UK business angel network located in Cambridge which education institutions in the East of England. exists to introduce ambitious, innovative companies seeking funding to business angels and other early-stage funders seeking quality Contact: Catherine Atkins investment opportunities. Email: [email protected] Web: www.geif.co.uk Tel: 07738 455166

The Cambridge Science Park is managed by Bidwells on behalf of Trinity College.

Management: Agency letting: Catalyst is a forum for Jeremy Tuck MRICS Jamie Green companies on the Email: [email protected] Email: [email protected] Cambridge Science Park. Tel: +44 (0) 1223 559333 Tel: +44 (0) 1223 841841 The next issue will be published in PR & marketing:

Autumn/Winter 2007. If you have Julie Bushell any comments or suggestions for Email: [email protected] stories to be included in the next Tel: +44 (0) 1223 559331 issue, please get in touch with Sherri Brazear Julie Bushell or Sherri Brazear (see right). Email: [email protected] Tel: +44 (0) 1223 559393

catalyst summer 200715 Viewpoint Dr Jeremy Fairbrother was Senior Bursar at Trinity College from 1993 until his retirement in 2007

three to five lanes. This also coincided with help new companies to get off the ground improvements by the road authorities outside within a prestigious setting for research and the Park on Milton Road, and more recently development. the construction of a direct lane onto the A14. “Flexibility has been the key throughout, because technology One of the other prominent developments companies may grow or has been the agreement which was secured contract, but they don’t stand with Trinity Hall to develop the land they still” Dr Fairbrother - Senior Bursar at owned at the back of Cambridge Science Park Trinity College from 1993 to 2007 as an integral part of the Park. That enabled I think it’s been important for Trinity College us to build a second entrance for the Park and to provide the fundamentals of what creates a Cambridge Science Park has been here since provided additional land for the construction successful science park, and to leave the actual 1973 – and a lot of things have changed in 34 of several major new buildings. science and commerce side to the companies years. But throughout that time, the development themselves. We need to provide top-quality of the Park has been driven by a passionate We also completely redeveloped the buildings, good access and infrastructure, feeling from the Fellows at Trinity College that conference facilities with the establishment of attractive landscaping and flexible leasing. If science and technology should be for the the new Trinity Centre. At the same time, we you can get these things right, the companies benefit of mankind, and that the commercial turned the old conference centre into a fitness should come to you and prosper. development of ideas is a crucial part of that. centre and created a purpose-built nursery which has been an extremely successful It’s been a wonderful privilege to have been By the time I became Senior Bursar in 1993, involved with the ongoing development of addition to the Park. Cambridge Science Park had already been Cambridge Science Park over these years, well established for 20 years. Since that time, “The development of the during which time the amount of building however, there have been a number of big Park has been driven by a space let by Trinity College has almost changes in technology that have influenced passionate feeling at Trinity doubled. Of course there will be some the way the Park has developed. We’ve seen College that science and important developments ahead, so I look the development of mobile communications, technology should be for the forward eagerly to learning about the ongoing the huge growth of the Internet, and the benefit of mankind” success of Cambridge Science Park and what tremendous strides taken in the unravelling of happens next in this remarkable story – one the human genome and our understanding of which continues to attract genuine interest how drugs work. Now we’ve reached a stage where we have and admiration from right around the world. developed most of the available land on the These changes are reflected in the type of site. But some of the simple buildings that companies that have set up and grown on were first put up in the 1970s have in fact Cambridge Science Park. The role of Trinity proved very popular with new tenants over College has been to respond to the changes the years, with the now mature landscaping in the market and to provide the facilities to providing a most attractive working ensure that Cambridge Science Park maintains environment. its premier status as a centre for research and development. Flexibility has been the key throughout, because technology companies may grow You need to be evolutionary but also or contract, but they certainly don’t stand still. flexible – by the mid 1990s there were a Our clients may not want to occupy number of significant developments that the whole of a building right from the needed to be made. It was very important start – but they might want space that they that we could improve access to the Park, can grow into. The development of the new which involved a number of different elements. Innovation Centre is typical of the kind of We widened the entrance road from flexible and practical letting arrangements that