Beyond Astronaut's Capabilities: a Critical
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A Quantitative Human Spacecraft Design Evaluation Model For
A QUANTITATIVE HUMAN SPACECRAFT DESIGN EVALUATION MODEL FOR ASSESSING CREW ACCOMMODATION AND UTILIZATION by CHRISTINE FANCHIANG B.S., Massachusetts Institute of Technology, 2007 M.S., University of Colorado Boulder, 2010 A thesis submitted to the Faculty of the Graduate School of the University of Colorado in partial fulfillment of the requirement for the degree of Doctor of Philosophy Department of Aerospace Engineering Sciences 2017 i This thesis entitled: A Quantitative Human Spacecraft Design Evaluation Model for Assessing Crew Accommodation and Utilization written by Christine Fanchiang has been approved for the Department of Aerospace Engineering Sciences Dr. David M. Klaus Dr. Jessica J. Marquez Dr. Nisar R. Ahmed Dr. Daniel J. Szafir Dr. Jennifer A. Mindock Dr. James A. Nabity Date: 13 March 2017 The final copy of this thesis has been examined by the signatories, and we find that both the content and the form meet acceptable presentation standards of scholarly work in the above mentioned discipline. ii Fanchiang, Christine (Ph.D., Aerospace Engineering Sciences) A Quantitative Human Spacecraft Design Evaluation Model for Assessing Crew Accommodation and Utilization Thesis directed by Professor David M. Klaus Crew performance, including both accommodation and utilization factors, is an integral part of every human spaceflight mission from commercial space tourism, to the demanding journey to Mars and beyond. Spacecraft were historically built by engineers and technologists trying to adapt the vehicle into cutting edge rocketry with the assumption that the astronauts could be trained and will adapt to the design. By and large, that is still the current state of the art. It is recognized, however, that poor human-machine design integration can lead to catastrophic and deadly mishaps. -
Asen 5016 Space Life Sciences
January 15, 2019 ASEN 5016 SPACE LIFE SCIENCES Spring 2019 Tues/Thurs 2:0-3:15 pm ECCS 1B28 Instructor: Dr. David Klaus telephone: (303) 492-3525 email: [email protected] This course is intended to familiarize engineering students with factors affecting living organisms (ranging from single cells to humans) in the reduced-gravity and increased radiation environment of space flight, including orbital, lunar and Martian surface conditions. Unique insight will be gained regarding engineering design requirements for spacecraft habitats, life support systems and spacesuits, as well as space biology payloads. Life support needs, as they relate to basic human survival requirements, are covered initially. Next, the lectures turn to more detailed descriptions of the physiological adaptations that occur to people in space, with pertinent background information presented for each topic. Corresponding biomedical countermeasures used to maintain crew health for long duration missions will also be discussed. Finally, the underlying biophysical mechanisms affected by gravity, along with experiment design criteria, will be addressed. Current events within NASA’s research and exploration mission programs and the emerging commercial human space flight sector are reflected throughout the lecture topics. To further elaborate on the lecture material discussed in class, a series of integrated homework tasks provides a practical introduction to the process of journal article publishing and research proposal writing, including the anonymous peer review process used for each. The assignment involves writing a short journal article on an approved topic of your choice, your participation as a peer reviewer for the editor, revising your draft per the review comments you receive back, and resubmitting a final manuscript with a corresponding summary of changes made. -
Soviet Steps Toward Permanent Human Presence in Space
SALYUT: Soviet Steps Toward Permanent Human Presence in Space December 1983 NTIS order #PB84-181437 Recommended Citation: SALYUT: Soviet Steps Toward Permanent Human Presence in Space–A Technical Mere- orandum (Washington, D. C.: U.S. Congress, Office of Technology Assessment, OTA- TM-STI-14, December 1983). Library of Congress Catalog Card Number 83-600624 For sale by the Superintendent of Documents, U.S. Government Printing Office, Washington, D.C. 20402 Foreword As the other major spacefaring nation, the Soviet Union is a subject of interest to the American people and Congress in their deliberations concerning the future of U.S. space activities. In the course of an assessment of Civilian Space Stations, the Office of Technology Assessment (OTA) has undertaken a study of the presence of Soviets in space and their Salyut space stations, in order to provide Congress with an informed view of Soviet capabilities and intentions. The major element in this technical memorandum was a workshop held at OTA in December 1982: it was the first occasion when a significant number of experts in this area of Soviet space activities had met for extended unclassified discussion. As a result of the workshop, OTA prepared this technical memorandum, “Salyut: Soviet Steps Toward Permanent Human Presence in Space. ” It has been reviewed extensively by workshop participants and others familiar with Soviet space activities. Also in December 1982, OTA wrote to the U. S. S. R.’s Ambassador to the United States Anatoliy Dobrynin, requesting any information concerning present and future Soviet space activities that the Soviet Union judged could be of value to the OTA assess- ment of civilian space stations. -
Treatment of ARDS*
Treatment of ARDS* Roy G. Brower, MD; Lorraine B. Ware, MD; Yves Berthiaume, MD; and Michael A. Matthay, MD, FCCP Improved understanding of the pathogenesis of acute lung injury (ALI)/ARDS has led to important advances in the treatment of ALI/ARDS, particularly in the area of ventilator- associated lung injury. Standard supportive care for ALI/ARDS should now include a protective ventilatory strategy with low tidal volume ventilation by the protocol developed by the National Institutes of Health ARDS Network. Further refinements of the protocol for mechanical ventilation will occur as current and future clinical trials are completed. In addition, novel modes of mechanical ventilation are being studied and may augment standard therapy in the future. Although results of anti-inflammatory strategies have been disappointing in clinical trials, further trials are underway to test the efficacy of late corticosteroids and other approaches to modulation of inflammation in ALI/ARDS. (CHEST 2001; 120:1347–1367) Key words: acute lung injury; mechanical ventilation; pulmonary edema; ventilator-associated lung injury Abbreviations: ALI ϭ acute lung injury; APRV ϭ airway pressure-release ventilation; ECco R ϭ extracorporeal ϭ ϭ 2 carbon dioxide removal; ECMO extracorporeal membrane oxygenation; Fio2 fraction of inspired oxygen; HFV ϭ high-frequency ventilation; I:E ϭ ratio of the duration of inspiration to the duration of expiration; IL ϭ interleukin; IMPRV ϭ intermittent mandatory pressure-release ventilation; IRV ϭ inverse-ratio ventilation; LFPPV ϭ low-frequency positive-pressure ventilation; NIH ϭ National Institutes of Health; NIPPV ϭ noninvasive positive-pressure ventilation; NO ϭ nitric oxide; PEEP ϭ positive end-expiratory pressure; PSB ϭ protected specimen brushing; TGI ϭ tracheal gas insufflation; TNF ϭ tumor necrosis factor he syndrome of acute respiratory distress in Standard Supportive Therapy T adults was first described in 1967.1 Until re- cently, most reported mortality rates exceeded 50%. -
Quarterly Newsletter
National Space Biomedical Research Institute Lorem ipsum dolor sit amet, consectetuer adipiscing elit. Nulla lectus mi, sodales ac, consectetuer sed, luctus sit amet, risus. Mauris tempusSociety quam sit amet mi. Mauris of sagittis Fellows augue nec augue. Fusce ipsum. Quarterly Newsletter Information for First Award Fellows Winter 2015 Cool Research Corner Measuring Intracranial Pressure aboard the Weightless Wonder VI Justin Lawley, Ph.D. 2013 NSBRI First Award Fellow In August of 2014, NSBRI investigators took to the sky in order to help identify the reason for visual impairments in astronauts. The current working hypothesis is that microgravity causes pressure inside the brain to increase, which causes deformation of the optic globe and thus changes in vision. To answer this question, Dr. Benjamin Levine of the Institute for Exercise and Environmental Medicine at UTSouthwestern Medical Center and his First Award Fellow, Dr. Justin Lawley, performed experiments onboard NASA’s C-9 aircraft (Weightless Wonder VI). Continued on Page 4 Thoughts from the Top: Interview with Dr. Jeffrey Sutton ……………… 2 2014 Summer Bioastronautics Institute Recap …………………………… 5 In This Issue: Fellow Spotlights: Allison Anderson and Julia Raykin ………………….. 7 Space Fun: Orion EFT-1 Quiz ……………………………………………. 10 Thoughts from the Top Interview of Dr. Jeffrey Sutton by 2013 NSBRI First Award Fellow Torin Clark, Ph.D. QN: Students and postdocs always wonder what the CEO does. Describe your “average day” at work. Dr. Sutton: The CEO is responsible for leading the development and execution of NSBRI’s strategy, in accord with our NASA cooperative agreement and to the benefit of all stakeholders. As CEO, I have daily management decisions, oversee the implementation of our plans, and am authorized to move funds, including those from the lead consortium institution (Baylor College of Medicine) to >60 recipient institutions in support of our science, technology, career development, and outreach programs. -
Human Adaptation to Space
Human Adaptation to Space From Wikipedia, the free encyclopedia Human physiological adaptation to the conditions of space is a challenge faced in the development of human spaceflight. The fundamental engineering problems of escaping Earth's gravity well and developing systems for in space propulsion have been examined for well over a century, and millions of man-hours of research have been spent on them. In recent years there has been an increase in research into the issue of how humans can actually stay in space and will actually survive and work in space for long periods of time. This question requires input from the whole gamut of physical and biological sciences and has now become the greatest challenge, other than funding, to human space exploration. A fundamental step in overcoming this challenge is trying to understand the effects and the impact long space travel has on the human body. Contents [hide] 1 Importance 2 Public perception 3 Effects on humans o 3.1 Unprotected effects 4 Protected effects o 4.1 Gravity receptors o 4.2 Fluids o 4.3 Weight bearing structures o 4.4 Effects of radiation o 4.5 Sense of taste o 4.6 Other physical effects 5 Psychological effects 6 Future prospects 7 See also 8 References 9 Sources Importance Space colonization efforts must take into account the effects of space on the body The sum of mankind's experience has resulted in the accumulation of 58 solar years in space and a much better understanding of how the human body adapts. However, in the future, industrialization of space and exploration of inner and outer planets will require humans to endure longer and longer periods in space. -
Space Medicine Association 2011 Executive Committee Ballot
Space Medicine Association 2011 Executive Committee Ballot Candidates President Elect (1 vote): 1. Kaz Shimada 2. Vernon McDonald Treasurer (1 vote): 1. Serena Aunon 2. Shannan Moynihan 3. Yael Barr Members at Large (2 votes): 1. Michelle Christgen 2. Steve Vanderark 3. Tara Castleberry 4. Frederick Bonato 5. Azhar Rafiq Please see the short biographies on the next pages To cast your vote, please reply to this email or send an email to: [email protected] with the names of your selected candidates. President Elect Position Kazuhito Shimada, M.D., Ph.D. Dr. Shimada is currently the chief of medical operations at Japanese space agency (JAXA). He has supported Japanese spaceflight crewmembers for STS-72, 87, 95, 92, 114, 123, 124, 119, 127, 131, and for ISS-19/20/21 and 22/23(21S). He supervised hypobaric and hyperbaric chamber operations, as well as weightlessness simulation diving at Tsukuba Space Cener. He served as Japanese and FAA AME, and is a vice president of FAI Medicophysiological Commission. He logged 700 hours on gliders and airplanes as a private pilot. 2010 Chief, JAXA Medical Operations 2008 AsMA Fellow 1997 ABPM board certification in Aerospace Medicine 1996 State of Ohio physician license 1993-1996 RAM at Wright State Univ.; 1995 MSci. in Aerospace Medicine 1993-present Flight Surgeon, JAXA (ex. NASDA, Japanese space agency) 1983-1992 Otolaryngology residence at Univ. of Tsukuba and Saku Central Hospital, then ENT practice at Ibaraki Kenritsu Chuo Hospital 1987 Ph.D.; Univ. of Tsukuba (auditory evoked response) 1983 M.D.; Univ. of Tsukuba, Japan President Elect Position Dr. -
TA 7: Human Exploration Destination Systems
NASA Technology Roadmaps TA 7: Human Exploration Destination Systems The 2015 NASA Technology Roadmaps have been replaced with the 2020 NASA Technology Taxonomy and the NASA Strategic Technology Integration Framework. Note: The 2015 NASA Technology Roadmaps will be archived and remain accessible via their current Internet address as well as via the new 2020 NASA Technology Taxonomy Internet page. Please visit https://www.nasa.gov/offices/oct/home/taxonomy to see the Taxonomy. July 2015 2015 NASA Technology Roadmaps July 2015 TA 7: Human Exploration Destination Systems Foreword NASA is leading the way with a balanced program of space exploration, aeronautics, and science research. Success in executing NASA’s ambitious aeronautics activities and space missions requires solutions to difficult technical challenges that build on proven capabilities and require the development of new capabilities. These new capabilities arise from the development of novel cutting-edge technologies. The promising new technology candidates that will help NASA achieve our extraordinary missions are identified in our Technology Roadmaps. The roadmaps are a set of documents that consider a wide range of needed technology candidates and development pathways for the next 20 years. The roadmaps are a foundational element of the Strategic Technology Investment Plan (STIP), an actionable plan that lays out the strategy for developing those technologies essential to the pursuit of NASA’s mission and achievement of National goals. The STIP provides prioritization of the technology candidates within the roadmaps and guiding principles for technology investment. The recommendations provided by the National Research Council heavily influence NASA’s technology prioritization. NASA’s technology investments are tracked and analyzed in TechPort, a web-based software system that serves as NASA’s integrated technology data source and decision support tool. -
Partial Liquid Ventilation Versus Conventional Mechanical Ventilation with High PEEP and Moderate Tidal Volume in Acute Respiratory Failure in Piglets
0031-3998/02/5202-0225 PEDIATRIC RESEARCH Vol. 52, No. 2, 2002 Copyright © 2002 International Pediatric Research Foundation, Inc. Printed in U.S.A. Partial Liquid Ventilation Versus Conventional Mechanical Ventilation with High PEEP and Moderate Tidal Volume in Acute Respiratory Failure in Piglets SIEGFRIED RÖDL, BERNDT URLESBERGER, IGOR KNEZ, DRAGO DACAR, AND GERFRIED ZOBEL Departments of Pediatrics [S.R., G.Z.], Neonatology [B.U.] and Cardiac Surgery [I.K., D.D.], University of Graz, A-8036 Graz, Austria ABSTRACT This prospective randomized pilot study aimed to test the measurements. When compared with control animals, partial hypotheses that partial liquid ventilation combined with a high liquid ventilation resulted in significantly better oxygenation positive end-expiratory pressure (PEEP) and a moderate tidal with improved cardiac output and oxygen delivery. Dead space volume results in improved gas exchange and lung mechanics ventilation appeared to be lower during partial liquid ventilation without negative hemodynamic influences compared with con- compared with conventional mechanical ventilation. No signifi- ventional mechanical ventilation in acute lung injury in piglets. cant differences were observed in airway pressures, pulmonary Acute lung injury was induced in 12 piglets weighing 9.0 Ϯ 2.4 compliance, and airway resistance between both groups. The kg by repeated i.v. injections of oleic acid and repeated lung results of this pilot study suggest that partial liquid ventilation lavages. Thereafter, the animals were randomly assigned either combined with high PEEP and moderate tidal volume improves to partial liquid ventilation (n ϭ 6) or conventional mechanical oxygenation, dead space ventilation, cardiac output, and oxygen ϭ ventilation (n 6) at a fractional concentration of inspired O2 of delivery compared with conventional mechanical ventilation in 1.0, a PEEP of 1.2 kPa, a tidal volume Ͻ 10 mL/kg body weight acute lung injury in piglets but has no significant influence on (bw), a respiratory rate of 24 breaths/min, and an inspiratory/ lung mechanics. -
Respiration (Physiology) 1 Respiration (Physiology)
Respiration (physiology) 1 Respiration (physiology) In physiology, respiration (often mistaken with breathing) is defined as the transport of oxygen from the outside air to the cells within tissues, and the transport of carbon dioxide in the opposite direction. This is in contrast to the biochemical definition of respiration, which refers to cellular respiration: the metabolic process by which an organism obtains energy by reacting oxygen with glucose to give water, carbon dioxide and ATP (energy). Although physiologic respiration is necessary to sustain cellular respiration and thus life in animals, the processes are distinct: cellular respiration takes place in individual cells of the animal, while physiologic respiration concerns the bulk flow and transport of metabolites between the organism and the external environment. In unicellular organisms, simple diffusion is sufficient for gas exchange: every cell is constantly bathed in the external environment, with only a short distance for gases to flow across. In contrast, complex multicellular animals such as humans have a much greater distance between the environment and their innermost cells, thus, a respiratory system is needed for effective gas exchange. The respiratory system works in concert with a circulatory system to carry gases to and from the tissues. In air-breathing vertebrates such as humans, respiration of oxygen includes four stages: • Ventilation, moving of the ambient air into and out of the alveoli of the lungs. • Pulmonary gas exchange, exchange of gases between the alveoli and the pulmonary capillaries. • Gas transport, movement of gases within the pulmonary capillaries through the circulation to the peripheral capillaries in the organs, and then a movement of gases back to the lungs along the same circulatory route. -
Evidence Report
Evidence Report: Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders Human Research Program Behavioral Health and Performance Approved for Public Release: Month DD, YYYY National Aeronautics and Space Administration Lyndon B. Johnson Space Center Houston, Texas CURRENT CONTRIBUTING AUTHORS: 1 Kelley J. Slack Wyle/LZ Technology Jason S. Schneiderman Wyle Lauren B. Leveton NASA Johnson Space Center Alexandra M. Whitmire Wyle James J. Picano Wyle PREVIOUS CONTRIBUTING AUTHORS: Camille Shea Houston Police Department Lacey L. Schmidt Minerva Work Solutions 2 TABLE OF CONTENTS I. PRD RISK TITLE: RISK OF ADVERSE COGNITIVE OR BEHAVIORAL CONDITIONS AND PSYCHIATRIC DISORDERS ............................................................................................. 6 II. EXECUTIVE SUMMARY .................................................................................................... 9 III. INTRODUCTION ................................................................................................................ 11 IV. EVIDENCE........................................................................................................................... 14 A. Space Flight Evidence .................................................................................................... 15 1. Sources of evidence .................................................................................................... 15 2. Occurrences of behavioral signs and symptoms ......................................................... 16 a. -
Shaffer CV 010419.Pdf
CURRICULUM VITAE Name: Thomas H. Shaffer, MS.E., Ph.D. Office Address: Temple University School of Medicine Department of Physiology 3420 North Broad Street Philadelphia, PA 19140 Office Address: Nemours Research Lung Center Department of Biomedical Research Alfred I. duPont Hospital for Children 1600 Rockland Road, A/R 302 Wilmington, DE 19803 Present Academic and Hospital Appointments: 2004 – Present Director, Nemours Center for Pediatric Research Nemours Biomedical Research Alfred I duPont Hospital for Children 1600 Rockland Road Wilmington, DE 19803 2001 - Present Associate Director , Nemours Biomedical Research Nemours Children’s Clinic – Wilmington of The Nemours Foundation Alfred I. duPont Hospital for Children, Wilmington, DE 19803 Director, Nemours Pediatric Lung Center Nemours Children's Clinic - Wilmington of The Nemours Foundation Alfred I. duPont Hospital for Children, Wilmington, DE Director, Office of Technology Transfer Nemours Children's Clinic - Wilmington of The Nemours Foundation Alfred I. duPont Hospital for Children, Wilmington, DE Professor, Pediatrics, Department of Pediatrics Thomas Jefferson University, College of Medicine, Philadelphia, PA 2001-Present Professor Emeritus, Physiology and Pediatrics, Departments of Physiology and Pediatrics Temple University School of Medicine, Philadelphia, PA 1 Training, Awards, Societies, and Membership: Education: 1963-1968 B.S. Mechanical Engineering, Drexel University, Philadelphia, PA 1968 Mathematics, Pennsylvania State University, State College, PA 1969-1970 MSE. Applied