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Cellular Models of Aging Oxidative Medicine and Cellular Longevity Cellular Models of Aging Guest Editors: Paula Ludovico, Heinz D. Osiewacz, Vitor Costa, and William C. Burhans Cellular Models of Aging Oxidative Medicine and Cellular Longevity Cellular Models of Aging Guest Editors: Paula Ludovico, Heinz D. Osiewacz, Vitor Costa, and William C. Burhans Copyright q 2012 Hindawi Publishing Corporation. All rights reserved. This is a special issue published in “Oxidative Medicine and Cellular Longevity.” All articles are open access articles dis- tributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Editorial Board Mohammad Abdollahi, Iran Michael R. Hoane, USA Sidhartha D. Ray, USA Antonio Ayala, Spain Vladimir Jakovljevic, Serbia Francisco Javier Romero, Spain Peter Backx, Canada Raouf A. Khalil, USA Gabriele Saretzki, UK Consuelo Borras, Spain Neelam Khaper, Canada Honglian Shi, USA Elisa Cabiscol, Spain Mike Kingsley, UK Cinzia Signorini, Italy Vittorio Calabrese, Italy Eugene A. Kiyatkin, USA Richard Siow, UK Shao-yu Chen, USA Lars-Oliver Klotz, Canada Sidney J. Stohs, USA Zhao Zhong Chong, USA Ron Kohen, Israel Oren Tirosh, Israel Felipe Dal-Pizzol, Brazil Jean-Claude Lavoie, Canada Madia Trujillo, Uruguay Ozcan Erel, Turkey C. H. Lillig, Germany Jeannette Vasquez-Vivar, USA Ersin Fadillioglu, Turkey Kenneth Maiese, USA Donald A. Vessey, USA Qingping Feng, Canada Bruno Meloni, Australia Victor M. Victor, Spain Swaran J. S. Flora, India Luisa Minghetti, Italy Michal Wozniak, Poland Janusz Gebicki, Australia Ryuichi Morishita, Japan Sho-ichi Yamagishi, Japan Husam Ghanim, USA Donatella Pietraforte, Italy Liang-Jun Yan, USA Daniela Giustarini, Italy Aurel Popa-Wagner, Germany Jing Yi, China Hunjoo Ha, Republic of Korea Jos L. Quiles, Spain Guillermo Zalba, Spain Giles E. Hardingham, UK Pranela Rameshwar, USA Cellular Models of Aging, Paula Ludovico, Heinz D. Osiewacz, Vitor Costa, and William C. Burhans Volume 2012, Article ID 616128, 3 pages DNA Mismatch Repair System: Repercussions in Cellular Homeostasis and Relationship with Aging, Juan Cristobal´ Conde-Perezprina,´ Miguel Angel´ Leon-Galv´ an,´ and Mina Konigsberg Volume 2012, Article ID 728430, 9 pages Therapeutic Targeting of Redox Signaling in Myofibroblast Differentiation and Age-Related Fibrotic Disease, Natalie Sampson, Peter Berger, and Christoph Zenzmaier Volume 2012, Article ID 458276, 15 pages Protein Oxidative Damage at the Crossroads of Cellular Senescence, Aging, and Age-Related Diseases, Martin A. Baraibar, Liang Liu, Emad K. Ahmed, and Bertrand Friguet Volume 2012, Article ID 919832, 8 pages Centrosome Aberrations Associated with Cellular Senescence and p53 Localization at Supernumerary Centrosomes, Susumu Ohshima Volume 2012, Article ID 217594, 9 pages Nuclear and Mitochondrial DNA Repair in Selected Eukaryotic Aging Model Systems, Ricardo Gredilla, Christian Garm, and Tinna Stevnsner Volume 2012, Article ID 282438, 12 pages Pleiotropic Cellular Functions of PARP1 in Longevity and Aging: Genome Maintenance Meets Inflammation, Aswin Mangerich and Alexander Brkle Volume 2012, Article ID 321653, 19 pages Persistent Amplification of DNA Damage Signal Involved in Replicative Senescence of Normal Human Diploid Fibroblasts, Masatoshi Suzuki, Keiji Suzuki, Seiji Kodama, Shunichi Yamashita, and Masami Watanabe Volume 2012, Article ID 310534, 8 pages Is Physical Activity Able to Modify Oxidative Damage in Cardiovascular Aging?, Graziamaria Corbi, Valeria Conti, Giusy Russomanno, Giuseppe Rengo, Piergiusto Vitulli, Anna Linda Ciccarelli, Amelia Filippelli, and Nicola Ferrara Volume 2012, Article ID 728547, 6 pages Overexpression of Fatty-Acid-β-Oxidation-Related Genes Extends the Lifespan of Drosophila melanogaster, Shin-Hae Lee, Su-Kyung Lee, Donggi Paik, and Kyung-Jin Min Volume 2012, Article ID 854502, 8 pages Nutraceutical Interventions for Promoting Healthy Aging in Invertebrate Models, Yuqing Dong, Sujay Guha, Xiaoping Sun, Min Cao, Xiaoxia Wang, and Sige Zou Volume 2012, Article ID 718491, 10 pages Contents Apple Can Act as Anti-Aging on Yeast Cells, Vanessa Palermo, Fulvio Mattivi, Romano Silvestri, Giuseppe La Regina, Claudio Falcone, and Cristina Mazzoni Volume 2012, Article ID 491759, 8 pages ROS in Aging Caenorhabditis elegans: Damage or Signaling?, Patricia Back, Bart P. Braeckman, and Filip Matthijssens Volume 2012, Article ID 608478, 14 pages Diet and Aging, Samo Ribaricˇ Volume 2012, Article ID 741468, 20 pages Yeast Colonies: A Model for Studies of Aging, Environmental Adaptation, and Longevity, Libuseˇ Vachov´ a,´ Michal Cˇ ap,´ and Zdena Palkova´ Volume 2012, Article ID 601836, 8 pages Growth Culture Conditions and Nutrient Signaling Modulating Yeast Chronological Longevity,Julia´ Santos, Cec´ılia Lea o, and Maria Joa˜ o Sousa Volume 2012, Article ID 680304, 10 pages Inhibition of Mitochondrial Cytochrome c Release and Suppression of Caspases by Gamma-Tocotrienol Prevent Apoptosis and Delay Aging in Stress-Induced Premature Senescence of Skin Fibroblasts, Suzana Makpol, Norhazira Abdul Rahim, Chua Kien Hui, and Wan Zurinah Wan Ngah Volume 2012, Article ID 785743, 13 pages Hindawi Publishing Corporation Oxidative Medicine and Cellular Longevity Volume 2012, Article ID 616128, 3 pages doi:10.1155/2012/616128 Editorial Cellular Models of Aging Paula Ludovico,1, 2 HeinzD.Osiewacz,3 Vitor Costa,4, 5 and William C. Burhans6 1 Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal 2 ICVS/3B’s-PT Government Associate Laboratory, Braga/Guimaraes,˜ Portugal 3 Department of Molecular Biosciences, Faculty of Biosciences and Cluster of Excellence Macromolecular Complexes, Johann Wolfgang Goethe-Universitat¨ Frankfurt, Max-von-Laue-Straße 9, 60438 Frankfurt, Germany 4 Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal 5 Instituto de Ciˆencias Biom´edicas Abel Salazar (ICBAS), Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal 6 Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA Correspondence should be addressed to Paula Ludovico, [email protected] Received 6 December 2012; Accepted 6 December 2012 Copyright © 2012 Paula Ludovico et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Biological aging is a complex and multifactorial process review articles provide an overview of current research and driven by genetic, environmental, and stochastic factors the status of experimentally accessible aging models. that lead to the physiological decline of biological systems. A number of contributions describe the molecular path- In humans, old age is the most important risk factor for ways that are part of the network controlling aging and the development of degenerative diseases, some of which longevity. S.-H. Lee and colleagues analyzed the effect of are severe (e.g., dementia, cancer). Understanding the basic overexpressing the two main components of fatty-acid β- mechanisms of aging is essential to the development of effec- oxidation and report that this genetic manipulation leads tive therapeutic interventions against age-related diseases. to lifespan extension of the corresponding Drosophila trans- Mechanisms of aging have been extensively investigated genic strains. They also show that the extension of lifespan in various model organisms and systems. Although results mediated by caloric restriction (CR) becomes reduced in obtained from studies with any model system should be the newly investigated strains. This appears to be related to viewed with caution when translated to human aging, much the activation of the dFOXO transcription factor, a known of the current understanding of conserved pathways involved regulator involved in longevity control. in aging and lifespan control was obtained from studies that In an original research article S. Makpol and col- employed experimentally tractable models. Aging research leagues address the molecular mechanism of γ-tocotrienol has now reached a stage where it is possible to move from (GTT) in preventing aging, focusing on its antiapoptotic a reductionist approach studying individual factors towards effects in stress-induced premature senescence (SIPS) of a more global analysis. With the recent development of human diploid fibroblasts (HDFs). Their results show that technologies that allow for the generation and computational SIPS cells exhibit senescent-phenotypic characteristics that analyses of large data sets, the ultimate goal is to unravel include increased expression of senescence-associated β- the various interacting molecular pathways governing aging galactosidase and G0/G1 cell cycle arrest accompanied by and thus elaborate a holistic understanding of this complex telomere shortening and decreased telomerase activity. Their process. findings suggest that GTT inhibits apoptosis and delays This special issue on was compiled with the following cellular senescence of HDFs by inhibiting the intrinsic aims: (i) to enhance our understanding of basic mechanisms mitochondria-mediated apoptotic pathway. of aging and (ii) to investigate potential interventions into In a review article, R. Gredilla and colleagues
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