Living with Your Pacemaker a Patient's Guide to Understanding Cardiac Pacemakers
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Chapter 20 *Lecture Powerpoint the Circulatory System: Blood Vessels and Circulation
Chapter 20 *Lecture PowerPoint The Circulatory System: Blood Vessels and Circulation *See separate FlexArt PowerPoint slides for all figures and tables preinserted into PowerPoint without notes. Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Introduction • The route taken by the blood after it leaves the heart was a point of much confusion for many centuries – Chinese emperor Huang Ti (2697–2597 BC) believed that blood flowed in a complete circuit around the body and back to the heart – Roman physician Galen (129–c. 199) thought blood flowed back and forth like air; the liver created blood out of nutrients and organs consumed it – English physician William Harvey (1578–1657) did experimentation on circulation in snakes; birth of experimental physiology – After microscope was invented, blood and capillaries were discovered by van Leeuwenhoek and Malpighi 20-2 General Anatomy of the Blood Vessels • Expected Learning Outcomes – Describe the structure of a blood vessel. – Describe the different types of arteries, capillaries, and veins. – Trace the general route usually taken by the blood from the heart and back again. – Describe some variations on this route. 20-3 General Anatomy of the Blood Vessels Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Capillaries Artery: Tunica interna Tunica media Tunica externa Nerve Vein Figure 20.1a (a) 1 mm © The McGraw-Hill Companies, Inc./Dennis Strete, photographer • Arteries carry blood away from heart • Veins -
Incidence of Post Cross Clamp Ventricular Fibrillation in Isolated Coronary Artery Bypass Surgery Using Del Nido Cardioplegia and Conventional Blood Cardioplegia
Jemds.com Original Research Article Incidence of Post Cross Clamp Ventricular Fibrillation in Isolated Coronary Artery Bypass Surgery Using del Nido Cardioplegia and Conventional Blood Cardioplegia Biju Kambil Thyagarajan1, Anandakuttan Sreenivasan2, Ravikrishnan Jayakumar3, Ratish Radhakrishnan4 1, 2, 3, 4 Department of Cardiovascular and Thoracic Surgery, Government T D Medical College, Alappuzha, Kerala, India. ABSTRACT BACKGROUND The cardiac surgical procedures and surgical outcomes witnessed a dramatic Corresponding Author: improvement with the introduction of cardiopulmonary bypass and cardioplegia Dr. Anandakuttan Sreenivasan, techniques. Ventricular fibrillation immediately after removal of aortic cross clamp is Department of Cardiovascular and an energy consuming process leading to myocardial injury in an already energy Thoracic Surgery, Government T D Medical College, Alappuzha, Kerala, India, depleted heart. Electrical cardioversion, which itself causes myocardial injury, is E-mail: [email protected] required to regain normal rhythm. Prevention of ventricular fibrillation is important in preventing myocardial injury. We retrospectively analysed the incidence of post DOI: 10.14260/jemds/2020/797 cross clamp ventricular fibrillation requiring electrical defibrillation in isolated coronary artery bypass surgery using del Nido cardioplegia and conventional blood How to Cite This Article: cardioplegia. Thyagarajan BK, Sreenivasan A, Jayakumar R, et al. Incidence of post cross clamp METHODS ventricular fibrillation in isolated coronary -
Presence of ROS in Inflammatory Environment of Peri-Implantitis Tissue
Journal of Clinical Medicine Article Presence of ROS in Inflammatory Environment of Peri-Implantitis Tissue: In Vitro and In Vivo Human Evidence 1, 2, 2, 3 4 Eitan Mijiritsky y, Letizia Ferroni y, Chiara Gardin y, Oren Peleg , Alper Gultekin , Alper Saglanmak 4, Lucia Gemma Delogu 5, Dinko Mitrecic 6, Adriano Piattelli 7, 8, 2,9, , Marco Tatullo z and Barbara Zavan * z 1 Head and Neck Maxillofacial Surgery, Department of Otoryngology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Weizmann street 6, 6423906 Tel-Aviv, Israel; [email protected] 2 Maria Cecilia Hospital, GVM Care & Research, Cotignola, 48033 Ravenna, Italy; [email protected] (L.F.); [email protected] (C.G.) 3 Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, 701990 Tel-Aviv, Israel; [email protected] 4 Istanbul University, Faculty of Dentistry, Department of Oral Implantology, 34093 Istanbul, Turkey; [email protected] (A.G.); [email protected] (A.S.) 5 University of Padova, DpT Biomedical Sciences, 35133 Padova, Italy; [email protected] 6 School of Medicine, Croatian Institute for Brain Research, University of Zagreb, Šalata 12, 10 000 Zagreb, Croatia; [email protected] 7 Department of Medical, Oral, and Biotechnological Sciences, University of Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy; [email protected] 8 Marrelli Health-Tecnologica Research Institute, Biomedical Section, Street E. Fermi, 88900 Crotone, Italy; [email protected] 9 Department of Medical Sciences, University of Ferrara, via Fossato di Mortara 70, 44123 Ferara, Italy * Correspondence: [email protected] Co-first author. -
Overview of Biomaterials and Their Use in Medical Devices
© 2003 ASM International. All Rights Reserved. www.asminternational.org Handbook of Materials for Medical Devices (#06974G) CHAPTER 1 Overview of Biomaterials and Their Use in Medical Devices A BIOMATERIAL, as defined in this hand- shapes, have relatively low cost, and be readily book, is any synthetic material that is used to available. replace or restore function to a body tissue and Figure 1 lists the various material require- is continuously or intermittently in contact with ments that must be met for successful total joint body fluids (Ref 1). This definition is somewhat replacement. The ideal material or material restrictive, because it excludes materials used combination should exhibit the following prop- for devices such as surgical or dental instru- erties: ments. Although these instruments are exposed A biocompatible chemical composition to to body fluids, they do not replace or augment • avoid adverse tissue reactions the function of human tissue. It should be noted, Excellent resistance to degradation (e.g., cor- however, that materials for surgical instru- • rosion resistance for metals or resistance to ments, particularly stainless steels, are reviewed biological degradation in polymers) briefly in Chapter 3, “Metallic Materials,” in Acceptable strength to sustain cyclic loading this handbook. Similarly, stainless steels and • endured by the joint shape memory alloys used for dental/endodon- A low modulus to minimize bone resorption tic instruments are discussed in Chapter 10, • High wear resistance to minimize wear- “Biomaterials for Dental Applications.” • debris generation Also excluded from the aforementioned defi- nition are materials that are used for external prostheses, such as artificial limbs or devices Uses for Biomaterials (Ref 3) such as hearing aids. -
CASODEX (Bicalutamide)
HIGHLIGHTS OF PRESCRIBING INFORMATION • Gynecomastia and breast pain have been reported during treatment with These highlights do not include all the information needed to use CASODEX 150 mg when used as a single agent. (5.3) CASODEX® safely and effectively. See full prescribing information for • CASODEX is used in combination with an LHRH agonist. LHRH CASODEX. agonists have been shown to cause a reduction in glucose tolerance in CASODEX® (bicalutamide) tablet, for oral use males. Consideration should be given to monitoring blood glucose in Initial U.S. Approval: 1995 patients receiving CASODEX in combination with LHRH agonists. (5.4) -------------------------- RECENT MAJOR CHANGES -------------------------- • Monitoring Prostate Specific Antigen (PSA) is recommended. Evaluate Warnings and Precautions (5.2) 10/2017 for clinical progression if PSA increases. (5.5) --------------------------- INDICATIONS AND USAGE -------------------------- ------------------------------ ADVERSE REACTIONS ----------------------------- • CASODEX 50 mg is an androgen receptor inhibitor indicated for use in Adverse reactions that occurred in more than 10% of patients receiving combination therapy with a luteinizing hormone-releasing hormone CASODEX plus an LHRH-A were: hot flashes, pain (including general, back, (LHRH) analog for the treatment of Stage D2 metastatic carcinoma of pelvic and abdominal), asthenia, constipation, infection, nausea, peripheral the prostate. (1) edema, dyspnea, diarrhea, hematuria, nocturia, and anemia. (6.1) • CASODEX 150 mg daily is not approved for use alone or with other treatments. (1) To report SUSPECTED ADVERSE REACTIONS, contact AstraZeneca Pharmaceuticals LP at 1-800-236-9933 or FDA at 1-800-FDA-1088 or ---------------------- DOSAGE AND ADMINISTRATION ---------------------- www.fda.gov/medwatch The recommended dose for CASODEX therapy in combination with an LHRH analog is one 50 mg tablet once daily (morning or evening). -
16 the Heart
Physiology Unit 3 CARDIOVASCULAR PHYSIOLOGY: THE HEART Cardiac Muscle • Conducting system – Pacemaker cells – 1% of cells make up the conducting system – Specialized group of cells which initiate the electrical current which is then conducted throughout the heart • Myocardial cells (cardiomyocytes) • Autonomic Innervation – Heart Rate • Sympathetic and Parasympathetic regulation • �1 receptors (ADRB1), M-ACh receptors – Contractility • Sympathetic stimulus • Effects on stroke volume (SV) Electrical Synapse • Impulses travel from cell to cell • Gap junctions – Adjacent cells electrically coupled through a channel • Examples – Smooth and cardiac muscles, brain, and glial cells. Conducting System of the Heart • SA node is the pacemaker of the heart – Establishes heart rate – ANS regulation • Conduction Sequence: – SA node depolarizes – Atria depolarize – AV node depolarizes • Then a 0.1 sec delay – Bundle of His depolarizes – R/L bundle branches depolarize – Purkinje fibers depolarize Sinus Rhythm: – Ventricles depolarize Heartbeat Dance Conduction Sequence Electrical Events of the Heart • Electrocardiogram (ECG) – Measures the currents generated in the ECF by the changes in many cardiac cells • P wave – Atrial depolarization • QRS complex – Ventricular depolarization – Atrial repolarization • T wave – Ventricular repolarization • U Wave – Not always present – Repolarization of the Purkinje fibers AP in Myocardial Cells • Plateau Phase – Membrane remains depolarized – L-type Ca2+ channels – “Long opening” calcium channels – Voltage gated -
A Mini-Review of Dental Implant Biomaterials
Mini Review Modifying an Implant: A Mini-review of Dental Implant Biomaterials Oliver K. Semisch-Dieter1, Andy H. Choi1, Besim Ben-Nissan1 and Martin P. Stewart1,* Abstract 1School of Life Sciences, Faculty of Science, University Dental implants have been used as far back as 2000BC, and since then have developed into highly sophisti- of Technology Sydney, Ultimo, cated solutions for tooth replacement. It is becoming increasingly important for the materials used in dental implants to exhibit and maintain favorable long-term mechanical, biological and more recently, aesthetic NSW, Australia properties. This review aims to assess the biomaterials used in modern dental implants, introducing their properties, and concentrating on modifications to improve these biomaterials. Focus is drawn to the promi- nent biomaterials, titanium (Ti) and zirconia due to their prevalence in implant dentistry. Additionally, novel coatings and materials with potential use as viable improvements or alternatives are reviewed. An effective *Correspondence to: dental biomaterial should osseointegrate, maintain structural integrity, resist corrosion and infection, and not Martin P. Stewart cause systemic toxicity or cytotoxicity. Current materials such as bioactive glass offer protection against bio- E-mail: martin.stewart@uts. film formation, and when combined with a titanium–zirconium (TiZr) alloy, provide a reliable combination edu.au of properties to represent a competitive alternative. Further long-term clinical studies are needed to inform the development of next-generation materials. Received: September 7 2020 Revised: December 7 2020 Keywords Accepted: January 4 2021 Biocompatibility, biomaterials, dental implant, titanium, zirconia. Published Online: March 19 2021 Significance Statement Available at: Biomaterials have become essential for modern implants. -
Religious-Verses-And-Poems
A CLUSTER OF PRECIOUS MEMORIES A bud the Gardener gave us, A cluster of precious memories A pure and lovely child. Sprayed with a million tears He gave it to our keeping Wishing God had spared you If only for a few more years. To cherish undefiled; You left a special memory And just as it was opening And a sorrow too great to hold, To the glory of the day, To us who loved and lost you Down came the Heavenly Father Your memory will never grow old. Thanks for the years we had, And took our bud away. Thanks for the memories we shared. We only prayed that when you left us That you knew how much we cared. 1 2 AFTERGLOW A Heart of Gold I’d like the memory of me A heart of gold stopped beating to be a happy one. I’d like to leave an afterglow Working hands at rest of smiles when life is done. God broke our hearts to prove to us I’d like to leave an echo He only takes the best whispering softly down the ways, Leaves and flowers may wither Of happy times and laughing times The golden sun may set and bright and sunny days. I’d like the tears of those who grieve But the hearts that loved you dearly to dry before too long, Are the ones that won’t forget. And cherish those very special memories to which I belong. 4 3 ALL IS WELL A LIFE – WELL LIVED Death is nothing at all, I have only slipped away into the next room. -
Young Adults. Look for ST Elevation, Tall QRS Voltage, "Fishhook" Deformity at the J Point, and Prominent T Waves
EKG Abnormalities I. Early repolarization abnormality: A. A normal variant. Early repolarization is most often seen in healthy young adults. Look for ST elevation, tall QRS voltage, "fishhook" deformity at the J point, and prominent T waves. ST segment elevation is maximal in leads with tallest R waves. Note high take off of the ST segment in leads V4-6; the ST elevation in V2-3 is generally seen in most normal ECG's; the ST elevation in V2- 6 is concave upwards, another characteristic of this normal variant. Characteristics’ of early repolarization • notching or slurring of the terminal portion of the QRS wave • symmetric concordant T waves of large amplitude • relative temporal stability • most commonly presents in the precordial leads but often associated with it is less pronounced ST segment elevation in the limb leads To differentiate from anterior MI • the initial part of the ST segment is usually flat or convex upward in AMI • reciprocal ST depression may be present in AMI but not in early repolarization • ST segments in early repolarization are usually <2 mm (but have been reported up to 4 mm) To differentiate from pericarditis • the ST changes are more widespread in pericarditis • the T wave is normal in pericarditis • the ratio of the degree of ST elevation (measured using the PR segment as the baseline) to the height of the T wave is greater than 0.25 in V6 in pericarditis. 1 II. Acute Pericarditis: Stage 1 Pericarditis Changes A. Timing 1. Onset: Day 2-3 2. Duration: Up to 2 weeks B. Findings 1. -
Lower Shore Clinic Richard Bearman, Clinic Director; Tuesday Trott, Clinic Administrator
Lower Shore Clinic Richard Bearman, Clinic Director; Tuesday Trott, Clinic Administrator Dedicated to serving the public, and particularly those without access to affordable and effective health care, Lower Shore Clinic maintains its commitment to the welfare of the people on the Lower Eastern Shore. This community based outpatient clinic exists to provide effective, integrated, and affordable mental health and primary care to people whose lack of means would otherwise prevent them from having any. No one is denied services for inability to pay. Lower Shore Clinic began operations in late 1999. The Wicomico public mental health clinic was originally operated by the County Health Department until 1997 when Peninsula Regional Medical Center (PRMC) took over for two and a half years. PRMC concluded that it could not afford to sustain the staggering financial losses operating the clinic entailed for it and the Wicomico County Health Officer asked Go-Getters, a community based psychiatric rehabilitation program, to step in. Lower Shore Clinic, an independent corporation, was founded and was granted an operating license. In early 2000, all 450 clients who wished to continue treatment and all therapists from the PRMC clinic were transferred seamlessly to Lower Shore Clinic. The clinic provides psychiatrists and psychiatric nurse practitioners who offer pharmacotherapy (medication) and therapists (nurses, social workers and counselors) who offer group and individual psychotherapy to assist people recovering from debilitating mental illness to live, work and play successfully in the larger community. Now, after twelve years as a mental health practice, Lower Shore Clinic added primary care in 2012, initially for its existing clients, but opening to the larger community in mid-2013. -
Flecainide Considerations For
Flecainide (Tambocor) Considerations for Use* US/FDA Approved Indications: Heart Rhythm Control for Atrial Fibrillation Black Box Warning* Proarrhythmic. Increased mortality in patients with non-life-threatening ventricular arrhythmias, structural heart disease (ie, MI, LV dysfunction); not recommended for use with chronic atrial fibrillation. Mechanism of Action Depresses phase 0 depolarization significantly, slows cardiac conduction significantly (Class 1C). Dosing† Cardioversion: 200 to 300 mg PO‡1 Maintenance: 50 to 150 mg PO every 12 hrs Hepatic Impairment: Reduce initial dosage. Monitor serum level frequently. Allow at least 4 days after dose changes to reach steady state level before adjusting dosage. Renal Impairment: CrCl > 35 ml/min: No dosage adjustment is required. CrCl <= 35 ml/min: Initially, 100 mg PO once daily or 50 mg PO twice daily. Adjust dosage at intervals > 4 days, since steady-state conditions may take longer to achieve in these patient Contraindications cardiogenic shock sick sinus syndrome or significant conduction delay 2nd/3rd degree heart block or bundle brand block without pacemaker acquired/congenital QT prolongation patients with history of torsade de pointes Major Side Effects hypotension, atrial flutter with high ventricular rate, ventricular tachycardia, HF Dosage forms and Strengths PO: 50, 100, 150mg tablets Special Notes Close monitoring of this drug is required. When starting a patient on flecainide, it is prudent to do a treadmill stress test after the patient is fully loaded.4 Do not use in patients with ischemic heart disease or LV dysfunction; increases risk of arrhythmias. Additional AV nodal blocking agent may be required to maintain rate control when AF recurs. -
Basic Rhythm Recognition
Electrocardiographic Interpretation Basic Rhythm Recognition William Brady, MD Department of Emergency Medicine Cardiac Rhythms Anatomy of a Rhythm Strip A Review of the Electrical System Intrinsic Pacemakers Cells These cells have property known as “Automaticity”— means they can spontaneously depolarize. Sinus Node Primary pacemaker Fires at a rate of 60-100 bpm AV Junction Fires at a rate of 40-60 bpm Ventricular (Purkinje Fibers) Less than 40 bpm What’s Normal P Wave Atrial Depolarization PR Interval (Normal 0.12-0.20) Beginning of the P to onset of QRS QRS Ventricular Depolarization QRS Interval (Normal <0.10) Period (or length of time) it takes for the ventricles to depolarize The Key to Success… …A systematic approach! Rate Rhythm P Waves PR Interval P and QRS Correlation QRS Rate Pacemaker A rather ill patient……… Very apparent inferolateral STEMI……with less apparent complete heart block RATE . Fast vs Slow . QRS Width Narrow QRS Wide QRS Narrow QRS Wide QRS Tachycardia Tachycardia Bradycardia Bradycardia Regular Irregular Regular Irregular Sinus Brady Idioventricular A-Fib / Flutter Bradycardia w/ BBB Sinus Tach A-Fib VT PVT Junctional 2 AVB / II PSVT A-Flutter SVT aberrant A-Fib 1 AVB 3 AVB A-Flutter MAT 2 AVB / I or II PAT PAT 3 AVB ST PAC / PVC Stability Hypotension / hypoperfusion Altered mental status Chest pain – Coronary ischemic Dyspnea – Pulmonary edema Sinus Rhythm Sinus Rhythm P Wave PR Interval QRS Rate Rhythm Pacemaker Comment . Before . Constant, . Rate 60-100 . Regular . SA Node Upright in each QRS regular . Interval =/< leads I, II, . Look . Interval .12- .10 & III alike .20 Conduction Image reference: Cardionetics/ http://www.cardionetics.com/docs/healthcr/ecg/arrhy/0100_bd.htm Sinus Pause A delay of activation within the atria for a period between 1.7 and 3 seconds A palpitation is likely to be felt by the patient as the sinus beat following the pause may be a heavy beat.