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Professor Departments of Pharmacology and Anesthesiology College of Medicine University of Arizona P.O CURRICULUM VITAE FRANK PORRECA, PH.D. Professor Departments of Pharmacology and Anesthesiology College of Medicine University of Arizona P.O. Box 245050 Tucson, Arizona 85724-5050 (520) 626-7421 (voice) (520) 626-4182 (facsimile) [email protected] (email) EDUCATION: 1975 B.S., General Science (Honors), Villanova University, Villanova, PA 1979 M.S., Biomedical Engineering, Drexel University, Philadelphia, PA 1982 Ph.D., Pharmacology, Temple University, School of Medicine, Philadelphia, PA 1982-1984 Merck Postdoctoral Research Associate, University of Arizona, Tucson, AZ PROFESSIONAL AND ACADEMIC APPOINTMENTS: 2006-2009 Director, Theme for Medical Neuroscience, College of Medicine 2005-present Associate Department Head, Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 2005-present Member, Arizona Cancer Center, University of Arizona, Tucson, AZ 2002-2003 Acting Department Head, Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 1995- present Professor of Pharmacology and Anesthesiology, College of Medicine, University of Arizona, Tucson, AZ 1991 - 1995 Professor of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 1988 - 1991 Associate Professor of Pharmacology (tenured), College of Medicine, University of Arizona, Tucson, AZ 1988-present Faculty Member, Program in Neuroscience, University of Arizona, Tucson, AZ 1985 - 1988 Assistant Professor of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 1984 - 1985 Assistant Professor of Pharmacology, Hahnemann University Medical School, Philadelphia, PA 1982 - 1984 Merck Postdoctoral Research Associate (Dr. Thomas F. Burks), Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 1 FRANK PORRECA, PH.D. SCHOLARLY ACTIVITIES RESEARCH HIGHLIGHTS AT THE UNIVERSITY OF ARIZONA My laboratory studies mechanisms that underlie chronic pain and headache with the goal of understanding pathophysiology and contributing to the discovery of new therapies for these conditions. Several themes are found in my research including (a) the role of descending modulatory circuits in pain and headache; (b) the intersection between pain and reward pathways; (c) the mechanisms by which opioids and stress engage these circuits and (d) the discovery of molecules that can act within these circuits to provide initial research tools that will allow preclinical validation of mechanism that may be ultimately translated to clinical application. We, and others in the field have come to the realization that in spite of our advances in understanding of the neurobiology of pain, this information has not led to many novel therapies. We have recently attempted to address one part of this problem by emphasizing research that may have increased relevance to the human pain experience. Specifically, we have attempted to capture and mechanistically evaluate affective dimensions of pain, i.e., the unpleasant or aversiveness that is a fundamental component of all pain experiences. Our approach has emphasized the motivational drive resulting from the unpleasantness of pain and the understanding that relief of pain is a reward. This principle has guided a series of experiments that have allowed us to address the mechanisms by which “pain relief” occurs. We have validated this approach using both clinically effective, and clinically ineffective treatments (i.e., reverse translation) and have confirmed that relief of pain engages the classical mesocorticolimbic reward circuit only in the presence of ongoing pain. This approach has been developed so that it may serve as a platform for discovery of new medications (forward translation) for treatment of pain and headache. Throughout these studies, we have emphasized the role of descending modulatory pathways in chronic pain and headache. One outcome has been to begin to understand why chronic pain happens relatively rarely after an injury in humans. We have not limited our studies to one “type” of pain and have explored acute, inflammatory, osteoarthritic, visceral, neuropathic and headache. Our questions are guided from observations made by our clinical colleagues through their interactions with patients. This is the basis of our translational strategy and the basis for choosing molecular targets for drug discovery. Our laboratory has worked with colleagues in chemistry for nearly 30 years and our efforts have discovered molecules that have been important research tools. We have recently emphasized the discovery of molecules with multifunctional features that can act simultaneously at more than one type of receptor in order to maximize efficacy while diminishing side effects. A potentially increased therapeutic window may result in medications that can treat pain and headache in specific patient populations while maximizing quality of life. My laboratory has been continuously NIH funded since 1982. H-index is 78. EDUCATIONAL ACTIVITIES AT THE UNIVERSITY OF ARIZONA Education has been an important component of my academic life at the University of Arizona. I have served as Director, or Co-Director of the Human Neuroscience course for Medical Students from 1994- 2000, a course continuously identified as the best basic science course in the College of Medicine by 2 FRANK PORRECA, PH.D. year one Medical Students during that period. I have taught extensively in the Medical Pharmacology course for year two Medical Students and have been Director of numerous graduate courses in the Program in Pharmacology. I have organized clinical electives for medical students to promote information relevant to their medical education. I have conducted a course on drugs of abuse for undergraduate students and regularly participate in undergraduate teaching for ethics. As a member of the former Interdisciplinary Program in Pharmacology and Toxicology, I have fostered graduate education by serving as the Director of an NIH sponsored Training Grant that supported both pre- and post-doctoral students. Such support of education has benefitted faculty and students in the Colleges of Medicine and Pharmacy as well as related faculty in the multidisciplinary graduate programs in Pharmacology and Toxicology and Neuroscience. As a part of my educational activities, I have served as the primary mentor to 20 students for their Ph.D., 8 students for their M.S. and the mentor for 23 post-doctoral fellows. I have also continuously sponsored undergraduate students in my laboratory. We have 13 undergraduates pursuing research in my laboratory in 2012-2013 as well as two visiting overseas scholars. SERVICE ACTIVITIES Service activities have included local intramural, and both national and international extramural activities aimed at citizenship within the College of Medicine at the University of Arizona and to the scientific disciplines of Pharmacology and Neuroscience. Some highlights of these activities include: President of the Western Pharmacology Society in 2000. The WPS is an international society comprised of scientists from United States, Canada, Mexico and Southeastern Asia established in 1947. As President, I organized and hosted the meeting in Tucson. The meeting was extremely successful and featured world-renowned speakers including Dr. Alfred Gilman, Nobel Prize winner, Dr. Floyd Bloom, former Editor of Science, Dr. Marc Caron and Dr. Thomas F. Burks. Member of the Board of Directors of the College on Problems of Drug Dependence, an organization that fosters research into mechanisms of drug addiction and dependence. Founder and Scientific organizer of the Spring Pain Research Conference. This is a premier conference that attracts the members of the world’s best pain laboratories in both academia and in industry that is held every two years. This meeting is attended by most of the world’s senior pain scientists and is widely regarded as one of the best conference in the field. Editor in Chief, Life Sciences (2008-2012) Section Editor, Pain (2000-2012) Editorial boards of many other journals (Journal of Pain, Journal of Neuroscience). Member of the Executive Council for the Committee on Neuroscience at the University of Arizona. Member of the Dean’s Research Council at the University of Arizona. 3 FRANK PORRECA, PH.D. Chair of the Promotions and Tenure Committee of the College of Medicine, University of Arizona; Member of many other College and University Committees. Member of the Focused Excellence Study Team for Cognitive and Neuroscience Research at the request of Provost. Member of the Dean’s Cabinet (Keith Joiner, Dean). HONORS, AWARDS AND HONORARY SERVICE Institute of Medicine, National Academy of Sciences, 2011 McGill Pain Day Speaker, 2012 Benson Lecturship, Johns Hopkins University, Baltimore, MD, 2011 Blaustein Lecture, Johns Hopkins University, Baltimore, MD, 2011 Distinguished Pain Professor, Mayo Clinic Rochester, 2004 Founder’s Day Speaker, University of Arizona, 2001 President, Western Pharmacology Society, 2000 F.W. Kerr Award, American Pain Society, 2000 Benjamin Covino Pain Professor, Harvard University, 2000 Sterling Visiting Professor, Albany Medical College, 2000 Research Fellow, American Association for the Advancement of Science Multiple plenary lectures at meetings worldwide each year Scientific Organizer, Spring Pain Research Conference Board of Directors, Committee on Problems of Drug Dependence (past member) Board of Directors, Spring Brain Conference Program Committee, International Association for the Study of Pain Nominating Committee, American
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