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Fruit Extract Mediated Green Synthesis of Metallic Nanoparticles: a New Avenue in Pomology Applications
International Journal of Molecular Sciences Review Fruit Extract Mediated Green Synthesis of Metallic Nanoparticles: A New Avenue in Pomology Applications Harsh Kumar 1 , Kanchan Bhardwaj 2, Daljeet Singh Dhanjal 3 , Eugenie Nepovimova 4, 5 6 3 2 7 Fatih S, en , Hailemeleak Regassa , Reena Singh , Rachna Verma , Vinod Kumar , Dinesh Kumar 1,* , Shashi Kant Bhatia 8,* and Kamil Kuˇca 4,9,* 1 Food Technology Department, School of Bioengineering and Food Technology, Shoolini University of Biotechnology and Management Sciences, Solan 173229, Himachal Pradesh, India; [email protected] 2 Botany Department, School of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, Himachal Pradesh, India; [email protected] (K.B.); [email protected] (R.V.) 3 Biotechnology Department, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, India; [email protected] (D.S.D.); [email protected] (R.S.) 4 Department of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech Republic; [email protected] 5 Sen Research Group, Biochemistry Department, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus, 43100 Kütahya, Turkey; [email protected] 6 Biotechnology Department, Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan 173229, Himachal Pradesh, India; [email protected] 7 School of Water, Energy and -
Antimicrobial Activity of Phyllanthus Emblica – a Medicinal Plant
European Journal of Molecular & Clinical Medicine ISSN 2515-8260 Volume 08, Issue 2 , 2020 ANTIMICROBIAL ACTIVITY OF PHYLLANTHUS EMBLICA – A MEDICINAL PLANT Abhay Jayprakash Gandhi1, Avdhoot Kulkarni2, Mitali Bora3, Lalit Hiray4 1. Phytochemist. National Institute of Ayurveda, Jaipur 2. Assistant professor, Dept of Pharmacology, Bharati Vidyapeeth Deemed University Medical College & Hospital, Sangli, Maharashtra, India 3. Associate General Manager, Micro Labs Advanced Research Center, Micro Labs Limited, Bangalore 4. Executive Associate General Manager, Micro Labs Advanced Research Center, Micro Labs Limited, Bangalore Address for correspondence: Dr. Abhay J. Gandhi, Department of Pharmacognosy, 1. Phytochemist. National Institute of Ayurveda, Jaipur E mail: [email protected] ABSTRACT: Objective: Phyllanthus emblica is an ethnomedicinal plant that has several medicinal claims and it hasn't been explored thoroughly. Various parts of the plant are used medicinally such as antioxidant, anti-inflammatory, analgesic and anti-pyretic etc. The study aims to explore the different qualitative, quantitative, and antifungal aspects of Phyllanthus emblica. Materials and methods: The present study was conducted to evaluate the anti-microbial activity of Phyllanthus emblica extracts against Gram- positive bacteria (Staphylococcus aureus), Gram-negative bacteria (E. coli), and Fungal (Candida albicans). The agar well diffusion method was used to test the antimicrobial activity. Result & Discussion: Phyllanthus emblica extracts exhibited potent antibacterial and antifungal against all the selected bacterial and fungal species. The extracts exhibited the growth inhibitory activity in a dose-dependent manner. Also, the study reveals Phyllanthus emblica shows good antimicrobial activity. Conclusion: The Phyllanthus emblica plant extracts could be used as an antimicrobial after comprehensive in-vitro biological studies. KEYWORDS : Phyllanthus emblica, Anti-microbial, Staphylococcus aureus, E. -
Gold Nanoparticles Prepared with Phyllanthus Emblica Fruit Extract and Bifidobacterium Animalis Subsp
nanomaterials Article Gold Nanoparticles Prepared with Phyllanthus emblica Fruit Extract and Bifidobacterium animalis subsp. lactis Can Induce Apoptosis via Mitochondrial Impairment with Inhibition of Autophagy in the Human Gastric Carcinoma Cell Line AGS Rongbo Wang 1, Xingyue Xu 1, Aditi Mitra Puja 1, Haribalan Perumalsamy 1 , Sri Renukadevi Balusamy 2 , Hoon Kim 3,* and Yeon-Ju Kim 1,3,* 1 Graduate School of Biotechnology, College of Life Science, Kyung Hee University, Yongin-si 17104, Korea; [email protected] (R.W.); [email protected] (X.X.); [email protected] (A.M.P.); [email protected] (H.P.) 2 Department of Food Science and Biotechnology, Sejong University, Gwangjin-gu, Seoul 05006, Korea; [email protected] 3 Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin-si 17104, Korea * Correspondence: [email protected] (H.K.); [email protected] (Y.-J.K.); Tel.: +82-31-888-6180 (H.K.); +82-31-201-5634 (Y.-J.K.) Citation: Wang, R.; Xu, X.; Puja, Abstract: (1) Background: Nanotechnology is being widely applied for anticancer strategies with A.M.; Perumalsamy, H.; Balusamy, few side effects. Nanoparticles (NPs) prepared from natural extracts are promising candidates S.R.; Kim, H.; Kim, Y.-J. Gold for cancer treatment because of their unique physicochemical characteristics. This study aimed to Nanoparticles Prepared with prepare gold nanoparticles (AuNPs) from Phyllanthus emblica fruit extract (PEFE) using Bifidobacterium Phyllanthus emblica Fruit Extract and animalis subsp. lactis (B. lactis) and to evaluate their anticancer activity against the human gastric Bifidobacterium animalis subsp. lactis adenocarcinoma cell-line (AGS). (2) Methods: The safety of microbial biosynthesis AuNPs (PEFE- Can Induce Apoptosis via AuNPs) was assessed by evaluating the cytotoxicity. -
(12) United States Patent (10) Patent No.: US 7,919,636 B2 Seeram Et Al
USOO7919636B2 (12) United States Patent (10) Patent No.: US 7,919,636 B2 Seeram et al. (45) Date of Patent: Apr. 5, 2011 (54) PURIFICATIONS OF POMEGRANATE Aviram, M., et al., “Pomegranate juice consumption inhibits serum ELLAGTANNINS AND THEIR USES angiotensin converting enzyme activity and reduces systolic blood THEREOF pressure.” (2001) Atherosclerosis, 158: 195-198. Cerda, B., et al., “Evaluation of bioavailability and metabolism in the (75) Inventors: Navindra P. Seeram, Los Angeles, CA rat of punicalagin, an antioxidant polyphenol from pomegranate juice.” (2003) Eur, J. Nutr., 42:18-28. (US); David Heber, Los Angeles, CA Cerda, B., et al., “Repeated oral administration of high doses of the (US) pomegranate elagitannin punicalaginto rats for 37 days is not toxic.” (2003) J. Agric. Food Chem. 51:3493-3501. (73) Assignee: The Regents of the University of Doig, A., et al., “Isolation and structure elucidation of punicalagin, a California, Oakland, CA (US) toxic hydrolysable tannin, from Terminalia oblongata.” (1990) J. Chem. Soc. Perkin Trans. I, 2317-2321. (*) Notice: Subject to any disclaimer, the term of this El-Toumy, S., et al., “Two ellagitannins from Punica granatum patent is extended or adjusted under 35 heartwood.” (2002) Phytochemistry, 61:971-974. U.S.C. 154(b) by 248 days. Filippich, L., et al., “Hepatotoxic and nephrotoxic principles in Terminalia oblongata.” (1991) Research in Veterinary Science, (21) Appl. No.: 12/143,657 50:17O-177. Gil, M., et al., “Antioxidant activity of pomegranate juice and its (22) Filed: Jun. 20, 2008 relationship with phenolic composition and processing.” (2000) J. Agric. Food Chem., 48:4581-4589. -
In Pomegranates – J
OPTIONS OPTIONS méditerranéennes méditerranéennes II International Symposium SERIES A: Mediterranean Seminars 2012 – Number 103 CIHEAM on the Pomegranate II International Symposium Edited by: P. Melgarejo, D. Valero on the Pomegranate Edited by: P. Melgarejo, D. Valero These Proceedings include 63 scientific papers presented at the II International Symposium on the Pomegranate, held in Madrid (Spain) from 19 to 21 October 2011. Production and commerce of pomegranate and its derived products have experienced significant growth everywhere in the world. Progress has been made in cultivation techniques and some traditional problems have been solved, although new problems such as Xanthomonas axonopodis attacks constitute a present threat. New public and private institutions in different countries are working to improve the on the Pomegranate production and quality of the pomegranate, and new varieties are being commercialized. The cultivar is a determining factor in issues related to nutritional composition and bioactive compounds with II International Symposium antioxidant activity. At the same time, significant advances in postharvest technologies have been made in the past years, specially focused on the use of technologies with natural compounds of great efficiency in maintaining OPTIONS OPTIONS méditerranéennes the quality and safety of pomegranate fruit during prolonged storage periods. méditerranéennes Special importance is attached to the advance in the industrialization processes through the technologies for processing ready-to-eat arils. In the past years, new protocols for quality evaluation using sensory analysis have been developed. With respect to the relationship between pomegranate and health, recent clinical studies report that pomegranate juice or extract can reduce the progression of prostate cancer, although more studies are needed to confirm these experimental results. -
Journal of Drug Delivery and Therapeutics Punica Granatum L
Kumari et al Journal of Drug Delivery & Therapeutics. 2021; 11(3):113-121 Available online on 15.05.2021 at http://jddtonline.info Journal of Drug Delivery and Therapeutics Open Access to Pharmaceutical and Medical Research © 2011-21, publisher and licensee JDDT, This is an Open Access article which permits unrestricted non-commercial use(CC By-NC), provided the original work is properly cited Open Access Full Text Article Review Article Punica granatum L. (Dadim), Therapeutic Importance of World’s Most Ancient Fruit Plant Kumari Isha, Kaurav Hemlata, Chaudhary Gitika* Shuddhi Ayurveda, Jeena Sikho Lifecare Pvt. Ltd. Zirakpur, 140603, Punjab, India Article Info: Abstract ___________________________________________ ______________________________________________________________________________________________________ Article History: The custom of using plants for the therapeutic and dietary practices is as old as origin of Received 23 March 2021; humanity on the earth. One of the most ancient fruit plant is Punica granatum L., Review Completed 20 April 2021 pomegranate belongs to Lythraceae family. The plant has a very rich ethnic history of its Accepted 26 April 2021; utilization around the world. The plant was used to symbolize prosperity, life, happiness, Available online 15 May 2021 fertility etc. Apart from the ethnic beliefs associated with the plant, it is a well-considered ______________________________________________________________ plant based remedy used in treatment of many diseases in traditional system like Ayurveda Cite this article as: and folk system of medicine. In Ayurveda it is esteemed as a Rasayana. It is used in many Ayurvedic polyherbal formulations which are used against many diseases. The plant Kumari I, Kaurav H, Chaudhary G, Punica granatum L. (Dadim), Therapeutic Importance of World’s Most consists of numerous phytochemical constituents in it such as polysaccharides, minerals, Ancient Fruit Plant, Journal of Drug Delivery and polyphenols, tannins, saponins, quinones, alkaloids, glycosides, coumarins, terpenoids, Therapeutics. -
Antioxidant and Antitumor Activity of Phyllanthus Emblica in Colon Cancer Cell Lines
Int.J.Curr.Microbiol.App.Sci (2013) 2(5): 189-195 ISSN: 2319-7706 Volume 2 Number 5 (2013) pp. 189-195 http://www.ijcmas.com Original Research Article Antioxidant and Antitumor activity of Phyllanthus emblica in colon cancer cell lines D. Sumalatha* Department of Biotechnology, Valliammal College for women, Chennai, Tamil Nadu, India. *Corresponding author e-mail: [email protected] A B S T R A C T The present study was designed to investigate the antioxidant and antitumor activity, of Phyllanthus emblica (fruit). Antioxidant potential of the edible plant was evaluated invitro by DPPH (1, 1 diphenyl 2 picrylhydrazyl) K e y w o r d s scavenging assay and FRAP assay method. The radical scavenging activity Phyto- of the extract was measured as decolourising activity followed by the chemicals; trapping of the unpaired electron of DPPH. The percentage decrease of antioxidant; DPPH standard solution was recorded 71.75% for Phyllanthus emblica cytotoxicity Phytochemical analysis revealed the presence of major phytocompounds assay; like alkaloids, flavanoids, protprocesseseins, sap oinvolvingnins and redoxTanni n enzymess. The c y andtoto xic Phyllanthus effect was determined against tbioenergeticshe cancer ce l l selectron lines H T - 2 transfer9 using t hande M T T emblica assay. In conclusion Phyllanthus emblica possess more potential cytotoxic activity against HT-29 cells lines .The result indicated that this plant extract could be an important dietary source with antioxidant & anticancer activities. Introduction Cancer is the abnormal growth of cells in exposure to a plethora of exogenous our bodies that can lead to death. Cancer chemicals (Rajkumar et al., 2011). -
Thowiba Mohammed Eltayeb Mohammed
Phytochemical Analysis and Antimicrobial Activities of Garad (Acacia nilotica L.) and Rumman (Punica granatum L.) Plants Thowiba Mohammed Eltayeb Mohammed B. Sc.( Honor) in Biology and Chemistry, Faculty of Education- Elhasahiesa, University of Gezira (2002) Post- graduate Diploma in Biosciences and Biotechnology, Center of Biosciences and Biotechnology, Faculty of Engineering and Technology (2004) M.sc in Biosciences and Biotechnology, Center of Biosciences and Biotechnology, Faculty of Engineering and Technology (Biosciences) (2009) A Thesis Submitted to the University of Gezira in Fulfillment of the Requirement for the Award of the Degree of Doctor of Philosophy in Biosciences and Biotechnology, (Microbiology) Center of Biosciences and Biotechnology Faculty of Engineering and Technology August 2015 1 Phytochemical Analysis and Antimicrobial Activities of Garad (Acacia nilotica L.) and Rumman (Punica granatum L.) Plants Thowiba Mohammed Eltayeb Mohammed Supervision Committee: Name Position Signature Prof / Awad Mohamed Abdel-Rahim Main Supervisor ………………. Dr. Mutaman Ali Abdelgadir Kehail Co – Supervisor ……………… Date: August, 2015 2 Phytochemical Analysis and Antimicrobial Activities of Garad (Acacia nilotica L) and Rumman (Punica granatum L.) Plants Thowiba Mohammed Eltayeb Mohammed Examination Committee: Name Position Signature Prof/ Awad Mohamed Abdel-Rahim Chairman --------------- Hassan Beshir ElAmin External Examiner -------------- Dr. Zakaria Ahmed Salih Internal Examiner --------------- Date of Examination 10 /08 /2015 3 بسم هللا -
Phyllanthus Emblica: the Superfood with Anti-Ulcer Potential
International Journal of Food Science and Nutrition International Journal of Food Science and Nutrition ISSN: 2455-4898 Impact Factor: RJIF 5.14 www.foodsciencejournal.com Volume 3; Issue 1; January 2018; Page No. 84-87 Phyllanthus emblica: The superfood with anti-ulcer potential Dr. Anindita Deb Pal Assistant Professor, Department of Food Science & Nutrition Management, J.D. Birla Institute, 11, Lower Rawdon Street, Kolkata, West Bengal, India Abstract The Indian Gooseberry is one of the commonly used plants in the Indian system of medicine. Amla is a wonder superfood, belonging to the genus Phyllanthus L. which is mainly distributed in tropical areas. It represents a phytochemical reservoir of biologically important molecules. The plant contains tannins, alkaloids, amino acids, carbohydrates, vitamins and organic acids. Various parts of the plant have been used to treat a wide array of diseases. The present article highlights the importance of Phyllanthus emblica in the prevention and treatment of ulcer. Gastrointestinal ulcer results due to an increase in the offensive factors as compared to defensive ulcer protective elements. The fruit extracts possesses potent anti-oxidant potential which is the key to its therapeutic effect. Additionally it is also capable of inducing neo-angiogenesis thereby helping in repair of gastric lesions. The anti-inflammatory potential of the above further accelerates ulcer healing. Owing to its anti-secretory and cyto- protective capacities, Phyllanthus emblica either alone or in combination represents a valuable natural strategy to treat several chronic diseases especially ulcer. Keywords: Amla, angiogenesis, anti-oxidant, Indian gooseberry, inflammation, ulcer 1. Introduction nutrition because not only do they help in nourishment but Plants have formed the basis of traditional medicine and drug also correct imbalances and help us towards a more natural development. -
Review Article Scientific Evaluation of Edible Fruits and Spices Used for the Treatment of Peptic Ulcer in Traditional Iranian Medicine
Hindawi Publishing Corporation ISRN Gastroenterology Volume 2013, Article ID 136932, 12 pages http://dx.doi.org/10.1155/2013/136932 Review Article Scientific Evaluation of Edible Fruits and Spices Used for the Treatment of Peptic Ulcer in Traditional Iranian Medicine Mohammad Hosein Farzaei,1 Mohammad Reza Shams-Ardekani,1,2 Zahra Abbasabadi,3 and Roja Rahimi1 1 Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran 1417653761, Iran 2 Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran 3 Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran Correspondence should be addressed to Roja Rahimi; [email protected] Received 26 June 2013; Accepted 24 July 2013 Academic Editors: J. M. Pajares, R. G. Romanelli, and W. Vogel Copyright © 2013 Mohammad Hosein Farzaei et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In traditional Iranian medicine (TIM), several edible fruits and spices are thought to have protective and healing effects on peptic ulcer (PU). The present study was conducted to verify anti-PU activity of these remedies. For this purpose, edible fruits and spices proposed for the management of PU in TIM were collected from TIM sources, and they were searched in modern medical databases to find studies that confirmed their efficacy. Findings from modern investigations support the claims of TIM about the efficacy of many fruits and spices in PU. The fruit of Phyllanthus emblica as a beneficial remedy for PU in TIM has been demonstrated to have antioxidant, wound healing, angiogenic, anti-H. -
Biodiversity in Karnali Province: Current Status and Conservation
Biodiversity in Karnali Province: Current Status and Conservation Karnali Province Government Ministry of Industry, Tourism, Forest and Environment Surkhet, Nepal Biodiversity in Karnali Province: Current Status and Conservation Karnali Province Government Ministry of Industry, Tourism, Forest and Environment Surkhet, Nepal Copyright: © 2020 Ministry of Industry, Tourism, Forest and Environment, Karnali Province Government, Surkhet, Nepal The views expressed in this publication do not necessarily reflect those of Ministry of Tourism, Forest and Environment, Karnali Province Government, Surkhet, Nepal Editors: Krishna Prasad Acharya, PhD and Prakash K. Paudel, PhD Technical Team: Achyut Tiwari, PhD, Jiban Poudel, PhD, Kiran Thapa Magar, Yogendra Poudel, Sher Bahadur Shrestha, Rajendra Basukala, Sher Bahadur Rokaya, Himalaya Saud, Niraj Shrestha, Tejendra Rawal Production Editors: Prakash Basnet and Anju Chaudhary Reproduction of this publication for educational or other non-commercial purposes is authorized without prior written permission from the copyright holder provided the source is fully acknowledged. Reproduction of this publication for resale or other commercial purposes is prohibited without prior written permission of the copyright holder. Citation: Acharya, K. P., Paudel, P. K. (2020). Biodiversity in Karnali Province: Current Status and Conservation. Ministry of Industry, Tourism, Forest and Environment, Karnali Province Government, Surkhet, Nepal Cover photograph: Tibetan wild ass in Limi valley © Tashi R. Ghale Keywords: biodiversity, conservation, Karnali province, people-wildlife nexus, biodiversity profile Editors’ Note Gyau Khola Valley, Upper Humla © Geraldine Werhahn This book “Biodiversity in Karnali Province: Current Status and Conservation”, is prepared to consolidate existing knowledge about the state of biodiversity in Karnali province. The book presents interrelated dynamics of society, physical environment, flora and fauna that have implications for biodiversity conservation. -
Pomegranate (Punica Granatum)
Functional Foods in Health and Disease 2016; 6(12):769-787 Page 769 of 787 Research Article Open Access Pomegranate (Punica granatum): a natural source for the development of therapeutic compositions of food supplements with anticancer activities based on electron acceptor molecular characteristics Veljko Veljkovic1,2, Sanja Glisic2, Vladimir Perovic2, Nevena Veljkovic2, Garth L Nicolson3 1Biomed Protection, Galveston, TX, USA; 2Center for Multidisciplinary Research, University of Belgrade, Institute of Nuclear Sciences VINCA, P.O. Box 522, 11001 Belgrade, Serbia; 3Department of Molecular Pathology, The Institute for Molecular Medicine, Huntington Beach, CA 92647 USA Corresponding author: Garth L Nicolson, PhD, MD (H), Department of Molecular Pathology, The Institute for Molecular Medicine, Huntington Beach, CA 92647 USA Submission Date: October 3, 2016, Accepted Date: December 18, 2016, Publication Date: December 30, 2016 Citation: Veljkovic V.V., Glisic S., Perovic V., Veljkovic N., Nicolson G.L.. Pomegranate (Punica granatum): a natural source for the development of therapeutic compositions of food supplements with anticancer activities based on electron acceptor molecular characteristics. Functional Foods in Health and Disease 2016; 6(12):769-787 ABSTRACT Background: Numerous in vitro and in vivo studies, in addition to clinical data, demonstrate that pomegranate juice can prevent or slow-down the progression of some types of cancers. Despite the well-documented effect of pomegranate ingredients on neoplastic changes, the molecular mechanism(s) underlying this phenomenon remains elusive. Methods: For the study of pomegranate ingredients the electron-ion interaction potential (EIIP) and the average quasi valence number (AQVN) were used. These molecular descriptors can be used to describe the long-range intermolecular interactions in biological systems and can identify substances with strong electron-acceptor properties.