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The Kraepelinian Tradition Paul Hoff, MD, Phd
Clinical research The Kraepelinian tradition Paul Hoff, MD, PhD Introduction n the 21st century, Emil Kraepelin’s views remain a majorI point of reference, especially regarding nosol- ogy and research strategies in psychiatry. However, the “neo-Kraepelinian” perspective has also been criticized substantially in recent years, the nosological dichotomy Emil Kraepelin (1856–1926) was an influential figure in of schizophrenic and affective psychoses being a focus the history of psychiatry as a clinical science. This pa- of this criticism. A thorough knowledge and balanced per, after briefly presenting his biography, discusses interpretation of Kraepelin’s work as it developed along- the conceptual foundations of his concept of mental side the nine editions of his textbook (published between illness and follows this line of thought through to late 1883 and 1927)1 is indispensable for a profound under- 20th-century “Neo-Kraepelinianism,” including recent standing of this important debate, and for its further de- criticism, particularly of the nosological dichotomy of velopment beyond the historical perspective. endogenous psychoses. Throughout his professional life, Kraepelin put emphasis on establishing psychiatry A brief biography as a clinical science with a strong empirical background. He preferred pragmatic attitudes and arguments, thus Emil Kraepelin was born in Neustrelitz (Mecklenburg, underestimating the philosophical presuppositions of West Pomerania, Germany) on February 15, 1856. He his work. As for nosology, his central hypothesis is the studied medicine in Leipzig and Wuerzburg from 1874 un- existence and scientific accessibility of “natural disease til 1878. He worked as a guest student at the psychiatric entities” (“natürliche Krankheitseinheiten”) in psychi- hospital in Wuerzburg under the directorship of Franz von atry. -
Single Molecule Enzymology À La Michaelis-Menten
Single molecule enzymology à la Michaelis-Menten Ramon Grima1, Nils G. Walter2 and Santiago Schnell3* 1 School of Biological Sciences and SynthSys, University of Edinburgh, Edinburgh, UK 2 Department of Chemistry, University of Michigan, Ann Arbor, Michigan, USA 3 Department of Molecular & Integrative Physiology, Department of Computational Medicine & Bioinformatics, and Brehm Center for Diabetes Research, University of Michigan Medical School, Ann Arbor, Michigan, USA * To whom the correspondence should be addressed. E-mail: [email protected] Review article accepted for publication to FEBS Journal special issue on Enzyme Kinetics and Allosteric Regulation 1 Abstract In the past one hundred years, deterministic rate equations have been successfully used to infer enzyme-catalysed reaction mechanisms and to estimate rate constants from reaction kinetics experiments conducted in vitro. In recent years, sophisticated experimental techniques have been developed that allow the measurement of enzyme- catalysed and other biopolymer-mediated reactions inside single cells at the single molecule level. Time course data obtained by these methods are considerably noisy because molecule numbers within cells are typically quite small. As a consequence, the interpretation and analysis of single cell data requires stochastic methods, rather than deterministic rate equations. Here we concisely review both experimental and theoretical techniques which enable single molecule analysis with particular emphasis on the major developments in the field of theoretical stochastic enzyme kinetics, from its inception in the mid-twentieth century to its modern day status. We discuss the differences between stochastic and deterministic rate equation models, how these depend on enzyme molecule numbers and substrate inflow into the reaction compartment and how estimation of rate constants from single cell data is possible using recently developed stochastic approaches. -
A Comprehensive Curriculum of the History of Regional Anesthesia
University of Massachusetts Medical School eScholarship@UMMS Anesthesiology and Perioperative Medicine Publications Anesthesiology and Perioperative Medicine 2019-09-18 A Comprehensive Curriculum of The History of Regional Anesthesia Gustavo Angaramo University of Massachusetts Medical School Et al. Let us know how access to this document benefits ou.y Follow this and additional works at: https://escholarship.umassmed.edu/anesthesiology_pubs Part of the Anesthesia and Analgesia Commons, Anesthesiology Commons, History of Science, Technology, and Medicine Commons, and the Medical Education Commons Repository Citation Angaramo G, Savage J, Arcella D, Desai MS. (2019). A Comprehensive Curriculum of The History of Regional Anesthesia. Anesthesiology and Perioperative Medicine Publications. Retrieved from https://escholarship.umassmed.edu/anesthesiology_pubs/193 Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 License. This material is brought to you by eScholarship@UMMS. It has been accepted for inclusion in Anesthesiology and Perioperative Medicine Publications by an authorized administrator of eScholarship@UMMS. For more information, please contact [email protected]. Journal of Clinical Anesthesia and Pain Medicine Research Article A Comprehensive Curriculum of The History of Regional Anesthesia This article was published in the following Scient Open Access Journal: Journal of Clinical Anesthesia and Pain Medicine Received August 30, 2019; Accepted September 12, 2019; Published September 18, 2019 1 Gustavo Angaramo , James Savage, Abstract David Arcella and Manisha S. Desai1* Department of Anesthesiology and Perioperative The study of the past with regards to medical history has been an underemphasized Medicine, University of Massachusetts Medical component of the medical school curriculum for several reasons. School, Worcester, Massachusetts. -
Covalent Modification of Reduced Flavin Mononucleotide in Type-2 Isopentenyl Diphosphate Isomerase by Active-Site-Directed Inhibitors
Covalent modification of reduced flavin mononucleotide in type-2 isopentenyl diphosphate isomerase by active-site-directed inhibitors Takuya Nagaia,1, Hideaki Unnob,1, Matthew Walter Janczakc,1, Tohru Yoshimuraa, C. Dale Poulterc,2, and Hisashi Hemmia,2 aDepartment of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8601, Japan; bDivision of Chemistry and Materials Science, Graduate School of Engineering, Nagasaki University, Bunkyo-machi, Nagasaki, Nagasaki 852-8521, Japan; and cDepartment of Chemistry, University of Utah, 315 South 1400 East RM2020, Salt Lake City, UT 84112 Contributed by C. Dale Poulter, October 11, 2011 (sent for review July 9, 2011) Evidence for an unusual catalysis of protonation/deprotonation by not detect signals for putative radical intermediates (9). Attempts a reduced flavin mononucleotide cofactor is presented for type-2 to inhibit the enzyme by incubation with a cyclopropyl analogue isopentenyl diphosphate isomerase (IDI-2), which catalyzes isomer- of IPP, designed to rearrange to a homoallylic structure by a ization of the two fundamental building blocks of isoprenoid bio- radical clock mechanism, were unsuccessful (12, 13). Instead, the synthesis, isopentenyl diphosphate and dimethylallyl diphosphate. analogue was an alternate substrate that isomerized to the cor- The covalent adducts formed between irreversible mechanism- responding DMAPP derivative without a cyclopropylcarbinyl- based inhibitors, 3-methylene-4-penten-1-yl diphosphate or 3-oxi- homoallyl radical rearrangement. ranyl-3-buten-1-yl diphosphate, and the flavin cofactor were inves- Mechanism-based inhibitors of IDI-1, which are activated by tigated by X-ray crystallography and UV-visible spectroscopy. Both protonation of epoxide and diene moieties in these compounds, the crystal structures of IDI-2 binding the flavin-inhibitor adduct – and the UV-visible spectra of the adducts indicate that the covalent also inactivate IDI-2 (12 15). -
Maud Menten, a Physician and Biochemist
Maud Menten Canadian medical researcher Maud Menten (1879-1960) has been called the "grandmother of biochemistry," a "radical feminist 1920s flapper," and a "petite dynamo." Not only was she an author of Michaelis-Menten equation for enzyme kinetics (like the plot in indigo in my portrait), she invented the azo-dye coupling for alkaline phosphatase, the first example of enzyme histochemistry, still used in histochemistry imaging of tissues today (which inspired the histology background of the portrait), and she also performed the first electrophoretic separation of blood haemoglobin in 1944! Born in Port Lambton, Ontario, she studied at the University of Toronto, earning her bachelor's in 1904, and then graduated from medical school (M.B., bachelor's of medicine) in 1907. She published her first paper with Archibald Macallum, the Professor of Physiology at U of T (who went on to set up the National Research Council of Canada), on the distribution of chloride ions in nerve cells in 1906. She worked a year at the Rockefeller Institute in New York, where along with Simon Flexner, first director of the Institute, she co-authored a book on radium bromide and cancer, the first publication produced by the Institute - barely 10 years after Marie Curie had discovered radium. She completed the first of two fellowships at Western Reserve University (now Case Western Reserve University), then she earned a doctorate in medical research in 1911 at U of T. She was one of the first Canadian women to earn such an advanced medical degree. She then moved to Berlin (travelling by boat, unfazed by the recent sinking of the Titanic) to work with Leonor Michaelis. -
The Agnew Clinic, an 1889 Oil Painting by American Artist Thomas Eakins
Antisepsis and women in surgery 12 The Gross ClinicThe, byPharos Thomas/Winter Eakins, 2019 1875. Photo by Geoffrey Clements/Corbis/VCG via Getty Images The Agnew Clinic, an 1889 oil painting by American artist Thomas Eakins. Universal History Archive/UIG via Getty images Don K. Nakayama, MD, MBA Dr. Nakayama (AΩA, University of California, San Francisco, Los Angeles, 1986, Alumnus), emeritus professor of history 1977) is Professor, Department of Surgery, University of of medicine at Johns Hopkins, referring to Joseph Lister North Carolina School of Medicine, Chapel Hill, NC. (1827–1912), pioneer in the use of antiseptics in surgery. The interpretation fits so well that each surgeon risks he Gross Clinic (1875) and The Agnew Clinic (1889) being consigned to a period of surgery to which neither by Thomas Eakins (1844–1916) face each other in belongs; Samuel D. Gross (1805–1884), to the dark age of the Philadelphia Museum of Art, in a hall large surgery, patients screaming during operations performed TenoughT to accommodate the immense canvases. The sub- without anesthesia, and suffering slow, agonizing deaths dued lighting in the room emphasizes Eakins’s dramatic use from hospital gangrene, and D. Hayes Agnew (1818–1892), of light. The dark background and black frock coats worn by to the modern era of aseptic surgery. In truth, Gross the doctors in The Gross Clinic emphasize the illuminated was an innovator on the vanguard of surgical practice. head and blood-covered fingers of the surgeon, and a bleed- Agnew, as lead consultant in the care of President James ing gash in pale flesh, barely recognizable as a human thigh. -
Cardiac Surgery
Gerhard Ziemer Axel Haverich Editors Cardiac Surgery Operations on the Heart and Great Vessels in Adults and Children 123 Cardiac Surgery Gerhard Ziemer Axel Haverich Editors Cardiac Surgery Operations on the Heart and Great Vessels in Adults and Children Editors Gerhard Ziemer Axel Haverich Department of Surgery HTTG - Surgery The University of Chicago Medizinische Hochschule Hannover Chicago, IL Hannover USA Germany ISBN 978-3-662-52670-5 ISBN 978-3-662-52672-9 (eBook) DOI 10.1007/978-3-662-52672-9 Library of Congress Control Number: 2017939170 © Springer-Verlag Berlin Heidelberg 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. -
Leonor Michaelis and Maud Leonora Menten Celebrating 100 Years of the Michaelis–Menten Equation
ARTICLE-IN-A-BOX Leonor Michaelis and Maud Leonora Menten Celebrating 100 years of the Michaelis–Menten Equation Leonor Michaelis was an honoured German biochemist and Maud Leonora Menten an honoured Canadian pathologist, during the nineteenth century. Though Michaelis sustained his interest in enzymology and biochemistry, Menten moved to pathology and became a renowned pathologist later in her career. The research collaboration of Michaelis and Menten was phenomenal resulting in the celebrated ‘Michaelis–Menten Equation’. Michaelis and Menten’s classic paper titled ‘Die Kinetik der Invertin wirkung’, published in Biochemische Zeitschrift in 1913 marks its centenary this year. This seminal paper which proved vital for the teaching of enzyme kinetics, was acknowledged with so much appreciation and attention that no textbook in biology for undergraduate and graduate students across the world is complete without a discussion of the Michaelis–Menten Equation. An earlier paper by Victor Henri and Brown lacked one important insight which was reported by Michaelis and Menten: that insight was the analysis of reaction in terms of the initial rate. Michaelis and Menten introduced the concept of measuring the initial activity of the enzyme by mixing it with substrate so that product accumulation would not inhibit the activity. Leonor Michaelis (1875–1949) Leonor Michaelis was born in Berlin, Germany on January 16, 1875. He graduated from the ‘humanistic’ Koellnisches Gymnasium in 1893. This gymnasium was special as unlike the other humanistic gymnasiums, it also included chemistry and physics labs which were not in general use and it was only the keen initiative of two professors that enabled interested students learn the subjects. -
Homenagem a August Karl Gustav Bier Por Ocasião Dos 100 Anos Da
Rev Bras Anestesiol ARTIGO DIVERSO 2008; 58: 4: 409-424 MISCELLANEOUS Homenagem a August Karl Gustav Bier por Ocasião dos 100 Anos da Anestesia Regional Intravenosa e dos 110 Anos da Raquianestesia* Eulogy to August Karl Gustav Bier on the 100th Anniversary of Intravenous Regional Block and the 110th Anniversary of the Spinal Block Almiro dos Reis Jr, TSA1 RESUMO Unitermos: ANESTESIA, Regional: subaracnóidea, venosa; Reis Jr. A — Homenagem a August Karl Gustav Bier por Ocasião dos ANESTESIOLOGIA: história. 100 Anos da Anestesia Regional Intravenosa e dos 110 Anos da Raquianestesia SUMMARY JUSTIFICATIVA E OBJETIVOS: August Karl Gustav Bier foi o in- Reis Jr A — Eulogy to August Karl Gustav Bier on the 100th Anni- trodutor de duas importantes técnicas de anestesia regional: a versary of Intravenous Regional Block and the 110th Anniversary of anestesia regional intravenosa e a anestesia subaracnóidea, Spinal Block. ambas até hoje amplamente empregadas. Completando neste ano de 2008 a primeira delas 100 anos e a segunda 110 anos de exis- BACKGROUND AND OBJECTIVES: August Karl Gustav Bier in- tência, seria mais do que justo prestarmos uma homenagem ao no- troduced two important techniques in regional block: intravenous tável médico que as criou. regional block and subarachnoid block, widely used nowadays. Since the first one celebrates its 100th anniversary and the second CONTEÚDO: O texto relata os dados familiares, estudantis inici- its 110th anniversary, it is only fair that we pay homage to this ex- ais, do curso acadêmico e da residência médica, as atividades pro- traordinary physician who created them. fissionais e universitárias, a personalidade, a aposentadoria e o falecimento de A. -
Nobel Laureate Surgeons
Literature Review World Journal of Surgery and Surgical Research Published: 12 Mar, 2020 Nobel Laureate Surgeons Jayant Radhakrishnan1* and Mohammad Ezzi1,2 1Department of Surgery and Urology, University of Illinois, USA 2Department of Surgery, Jazan University, Saudi Arabia Abstract This is a brief account of the notable contributions and some foibles of surgeons who have won the Nobel Prize for physiology or medicine since it was first awarded in 1901. Keywords: Nobel Prize in physiology or medicine; Surgical Nobel laureates; Pathology and surgery Introduction The Nobel Prize for physiology or medicine has been awarded to 219 scientists in the last 119 years. Eleven members of this illustrious group are surgeons although their awards have not always been for surgical innovations. Names of these surgeons with the year of the award and why they received it are listed below: Emil Theodor Kocher - 1909: Thyroid physiology, pathology and surgery. Alvar Gullstrand - 1911: Path of refracted light through the ocular lens. Alexis Carrel - 1912: Methods for suturing blood vessels and transplantation. Robert Barany - 1914: Function of the vestibular apparatus. Frederick Grant Banting - 1923: Extraction of insulin and treatment of diabetes. Alexander Fleming - 1945: Discovery of penicillin. Walter Rudolf Hess - 1949: Brain mapping for control of internal bodily functions. Werner Theodor Otto Forssmann - 1956: Cardiac catheterization. Charles Brenton Huggins - 1966: Hormonal control of prostate cancer. OPEN ACCESS Joseph Edward Murray - 1990: Organ transplantation. *Correspondence: Shinya Yamanaka-2012: Reprogramming of mature cells for pluripotency. Jayant Radhakrishnan, Department of Surgery and Urology, University of Emil Theodor Kocher (August 25, 1841 to July 27, 1917) Illinois, 1502, 71st, Street Darien, IL Kocher received the award in 1909 “for his work on the physiology, pathology and surgery of the 60561, Chicago, Illinois, USA, thyroid gland” [1]. -
Femoral Nerve Blocks
Femoral Nerve Blocks Julie Ronnebaum, DPT, GCS, CEEAA Objectives 1. Become familiar with the evolution of peripheral nerve blocks. 2. Describe the advantages and disadvantages of femoral nerve blocks 3. Identify up-to-date information on the use of femoral nerve block. 4. Recognize future implications. History of Anesthesia The use of anesthetics began over 160 years ago. General Anesthesia In 1845, Horace Wells used nitrous oxide gas during a tooth extraction 1st- public introduction of general anesthesia October 16, 1846. Known as “Ether Day” ( William Morton) In front of audience at Massachusetts General Hospital First reported deat h in 1847 due to the ether Other complications Inttouctoroduction to eteteher was ppoogerolonged Vomiting for hours to days after surgery Schatsky, 1995, Hardy, 2001 History of Anesthesia In 1874, morphine introduced as a pain killer. In 1884, August Freund discovers cy clopropane for surgery Problem is it is very flammable In 1898, heroin was introduced for the addiction to morphine In 1923 Arno Luckhardt administered ethylene oxygen for an anesthetic History of Anesthesia Society History of Anesthesia Alternatives to general anesthesia In the 1800’s Cocaine used by the Incas and Conquistadors 1845, Sir Francis Rynd applied a morphine solution directly to the nerve to relieve intractable neuralgg(ia. ( first recorded nerve block) Delivered it by gravity into a cannula In 1855, Alexander Wood is a glass syringe to deliver the medication for a nerve block. ( also known as regg)ional anesthesia) In 1868 a Peruvian surgeon discovered that if you inject cocaine into the skin it numbed it. In 1884, Karl Koller discovered cocaine could be used to anesthetized the eye of a frog. -
Gerald Edelman - Wikipedia, the Free Encyclopedia
Gerald Edelman - Wikipedia, the free encyclopedia Create account Log in Article Talk Read Edit View history Gerald Edelman From Wikipedia, the free encyclopedia Main page Gerald Maurice Edelman (born July 1, 1929) is an Contents American biologist who shared the 1972 Nobel Prize in Gerald Maurice Edelman Featured content Physiology or Medicine for work with Rodney Robert Born July 1, 1929 (age 83) Current events Porter on the immune system.[1] Edelman's Nobel Prize- Ozone Park, Queens, New York Nationality Random article winning research concerned discovery of the structure of American [2] Fields Donate to Wikipedia antibody molecules. In interviews, he has said that the immunology; neuroscience way the components of the immune system evolve over Alma Ursinus College, University of Interaction the life of the individual is analogous to the way the mater Pennsylvania School of Medicine Help components of the brain evolve in a lifetime. There is a Known for immune system About Wikipedia continuity in this way between his work on the immune system, for which he won the Nobel Prize, and his later Notable Nobel Prize in Physiology or Community portal work in neuroscience and in philosophy of mind. awards Medicine in 1972 Recent changes Contact Wikipedia Contents [hide] Toolbox 1 Education and career 2 Nobel Prize Print/export 2.1 Disulphide bonds 2.2 Molecular models of antibody structure Languages 2.3 Antibody sequencing 2.4 Topobiology 3 Theory of consciousness Беларуская 3.1 Neural Darwinism Български 4 Evolution Theory Català 5 Personal Deutsch 6 See also Español 7 References Euskara 8 Bibliography Français 9 Further reading 10 External links Hrvatski Ido Education and career [edit] Bahasa Indonesia Italiano Gerald Edelman was born in 1929 in Ozone Park, Queens, New York to Jewish parents, physician Edward Edelman, and Anna Freedman Edelman, who worked in the insurance industry.[3] After עברית Kiswahili being raised in New York, he attended college in Pennsylvania where he graduated magna cum Nederlands laude with a B.S.