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Sponsor Bergen University Indication and Treatment of Adult Spinal Deformity the INTRAKS-Study

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Sponsor Bergen University Indication and Treatment of Adult Spinal Deformity the INTRAKS-Study Sponsor Bergen University Indication and treatment of adult spinal deformity The INTRAKS-study 26.08.2020 1 Indications and Treatment of Adult Kypho- Scoliosis (INTRAKS Study) 2. Introduction Background of kyphoscoliosis and its challenges: Kyphosis is the normal forward rounding of the spine in its double S- shape. Excessive kyphosis can render the spine out of balance. The scoliosis is a sideways curvature of the back. Both adult kyphosis and scoliosis is a common result of degeneration in age. Correction surgery of spine deformities has been done for decades. This type of surgery has been accompanied by complications and variation in outcome and success, therefore, correction surgery of the spine has been reserved as a last resort. Recently, improved surgical techniques for osteotomies and development of equipment has led to a change and increase in indications. There is a need for well conducted studies on this patient group. Therefore, this study aims to evaluate outcome of different treatment options. Some of the reason for the increase in number of patients treated, is an aging population in the industrialized world combined with higher demands for being active at an older age. Patients with kyphoscoliosis disorders that are out of balance, can continue to decompensate, resulting in further nerve-, dura- and spinal cord compression. Suffering from severe pain, paresis and functional deficits, they are not able to participate in the daily life or take care of themselves. The risk for complications by the kyphotic disorder has to be weighed against the benefit of some pain reduction and increased function, even though they face a 30-70% risk of complications, 20- 40% of these being major complications that can result in paralysis, bowel- and bladder dysfunction, infections, hardware failure and more [1-8]. These patients already account for large healthcare and social costs. The adult scoliotic disorder can be easier assessed, with less complications, but a combination of kyphosis and scoliosis can also be the case. Decision making in patient’s selection for kyphoscoliosis treatment Kyphoscoliotic patients have often been through various conservative treatment options in order to strengthen the trunk muscles and often combined with increasing analgesic treatment. In time, conservative treatment might not be sufficient to prevent patients from decompensating and to develop severe back pain and sometimes radicular pain and impaired function. Adult kyphoscoliosis are mostly caused by either primary degeneration, fractures or failure after surgery. Pain and neurological deficits often render patients unable to perform activities necessary for daily living. Additionally, many of these older patients struggle with several comorbidities. These factors in addition to osteoporosis can therefore complicate the surgical planning and treatment. Future projections predict an increasing older population in industrialized countries and in age osteoporosis is more frequent then in the younger population The incidence of spine fractures due to osteoporosis is significant, resulting in a high number of patients in need of correctional osteotomies [9, 10]. Current indications for surgery by kyphotic disorder is a kyphotic misbalance (widely classified as more than 4 cm off positive sagittal vertical axis (SVA)), regional kyphosis above 20degrees, therapy resistant dorsalgia with radiculopathy and neurological deficits. The scoliotic disorder is often due to degeneration and located in the lumbar, partly in the thoracic spine. A spinal stenosis with a scoliotic disorder and a Cobb angle <20 degrees, can benefit from decompression alone, >20 degrees often needs to be considered for a short or long fixation. Overlooked patients in kyphotic- or scoliotic misbalance undergoing minor spine surgery can have short beneficial effect, but will often soon regain their prior symptoms. A combination of kyphosis and scoliosis is often seen and needs to be addressed although the sagittal condition often is the main problem treating this deformity. Surgical treatment options Surgical correction is the only option to improve the balance of the spine by larger angulations and hereby possibly improve clinical outcome. The preferred surgical techniques are anterior release and cage insertion such as Extreme-, Direct- or Oblique lateral interbody fusion (XLIF, DLIF, OLIF) [11] with combined short segment dorsal fixation, as well as Smith Petersen (SP)-/Ponte- and Pedicle subtraction osteotomies (PSO) with multi segmental dorsal fixation [12-15] with or without additional cages in the cases of kyphotic- or kyphoscoliotic disorder. The scoliotic disorders are mostly corrected from a dorsal approach with decompression, Smith Petersen (SP)-/Ponte Osteotomies in multiple levels and long fixation. TLIF, OLIF or XLIF might also address the deformity, the cages in the disc space can aid ventral support and correction in both disorders. Cages provide better stability and might hence reduce screw loosening by kyphosis [14, 16]. In 2 cases with osteoporosis, cement is often added to the screws or kyphoplasty techniques to the vertebra aiming to improve the fixation. Surgical technique is still a great area of debate. Several articles show a great number of complications such as pseudarthrosis [17-19], proximal junction kyphosis or failure (PJK/PJF) [20-36], neurological complications [37, 38], infection and screw loosening [39, 40]. Osteoporosis in the aging population complicates the treatment and method of surgery further. The consequences of these various surgical techniques are neither fully studied nor understood [41-45]. Another challenge is how to accurately measure and safely perform the desired angulation during surgery. Adjacent level disease (ALD) ALD is a common complication after long fixation of the thoracolumbar spine in the adjacent level to the fixation, often resulting in degeneration, spinal stenosis and/or listhesis. Several articles describe the issue, however it is unclear whether ALD is initiated by the rigidity of the fixation or a natural development. If the spinal fixation reaches down to the sacrum (S1), the sacroiliac (SI) joint is the distal adjacent level. The fixation might work as a lever arm causing increased movement or stresses leading to degeneration of the joint. This can lead to pelvic girdle pain [46, 47]. 2.1 Needs description: Following are challenges that still remain to be addressed: 1. Identify predictors for unsatisfactory outcome in adult kyphoscoliosis. This study aims to create a predictive model for unsatisfactory outcome after deformity surgery in adult kyphoscoliosis. A prospective multicenter observational effectiveness study is constructed to detect a < 30% improvement from baseline in Oswestry Disability Index (ODI) score at 12 months follow up. The predictive model can be a helpful tool in accessing the complexity of this patients and aid in shard decision making and improved surgical planning. Patients are grouped in: 1) unsatisfactory result (UR) < 30% increase from baseline ODI score, 2) satisfactory result (SR) ≥ 30% increase from baseline ODI score. A predictive model will be calculated for both kyphosis and scoliosis together and separately. The same criteria for inclusion are set in the non-surgical group as well as all the data collected, a predictive model will be created if the difference in outcome is significant. The investigators will also look at the patients with a > 10% worsening from baseline in ODI score at 12 months follow up. 2. A prospective multicenter observational effectiveness study of adult kyphoscoliosis treatment, surgical and non-surgical outcome with a 12 months follow up. a) This part of the study will be looking at the effectiveness of surgery vs non-surgical treatment using the PROMS described in the protocol. It is outcome related, the planned follow up time is 12 months, but the investigators have ethical approval (REK) to continue the data recording for 24 months and more for a sufficient follow up time. It exceeds the time limit for the PhD candidates listed, but others will continue the work. It will contain all the patients included. b) The subgroups of iatrogenic/degenerative kyphosis and scoliosis will be studied separately as it is known that the mainly scoliotic patients do better than the kyphotic once. Around 30-40 patients will be sufficient in each surgical subgroup, the same in the non-surgical. 3. The kyphotic healed high energy fracture. One of the subgroups to be investigated is the high energy fractures healed in kyphosis. High energy fractures are typical males in the age of 25-50. The fractures healed in kyphosis with a regional kyphotic angle of >20 degrees and a positive sagittal vertical axis of >4 cm can be included (the rest of the inclusion or exclusion criteria listed will be followed as for the whole study). As this is a subgroup, around 30-40 surgical patients will be sufficient. The investigators hope to have the same number in the non-surgical group to compare with. The main outcome parameter is ODI, but the investigators will also look into the results of the EQ-5D, SRS22 and the numeric rating scale (NRS). As this is a fracture resulting in a secondary deformity, the PROMS listed should be addressing the patient problems. 4. XLIF vs anterior-/transforaminal interbody fusion/pedicle subtraction osteotomy/Smith Petersen/Ponte (ALIF/TLIF/PSO/SP/Ponte). There is a trend towards using XLIF and OLIF procedures for deformity cases. The investigating
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