Narcotics Dangerous Drugs
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
CSAS Narcotic Treatment Service for Opiate Addiction Initial Certification
DEPARTMENT OF HEALTH SERVICES STATE OF WISCONSIN Division of Quality Assurance Page 1 of 16 F-00538 (11/11) COMMUNITY SUBSTANCE ABUSE SERVICE (CSAS) NARCOTIC TREATMENT SERVICE FOR OPIATE ADDICTION INITIAL CERTIFICATION APPLICATION Chapter DHS 75.15 Initial Certification • Initial certification must meet all requirements, including staffing requirements (hired and in place) before services begin. • This document paraphrases the rule language for application purposes. • Applicants for a new narcotic treatment service for opiate addiction must demonstrate preparedness to comply with all Chapter DHS 75.15 standards. Applicants will have completed all required policies, including Chapter DHS 94 (Patient Rights). Use the check boxes ( ) to affirm readiness to meet standards. • ATTENTION: The clinic must contact the regional Health Services Specialist to arrange a site visit following the submission of fee and this application. Chapter DHS 75.01(1) Authority and Purpose This application is promulgated under the authority of ss. 46.973(2)(c), 51.42(7)(b), and 51.45(8) and (9), Wis. Stats., to establish standards for community substance abuse prevention and treatment services under ss. 51.42 and 51.45, Wis. Stats. Sections 51.42(1) and 51.45(1) and (7) provide that a full continuum of substance abuse services be available to Wisconsin citizens from county departments of community programs, either directly or through written agreements or contracts that document the availability of services. This application provides that service recommendations for initial placement, continued stay, level of care transfer, and discharge of a patient be made through the use of Wisconsin uniform placement criteria (WI- UPC), American Society of Addiction Medicine (ASAM) placement criteria, or similar placement criteria that may be approved by the department. -
Khat Chewing, Cardiovascular Diseases and Other Internal Medical Problems: the Current Situation and Directions for Future Research
Journal of Ethnopharmacology 132 (2010) 540–548 Contents lists available at ScienceDirect Journal of Ethnopharmacology journal homepage: www.elsevier.com/locate/jethpharm Review Khat chewing, cardiovascular diseases and other internal medical problems: The current situation and directions for future research A. Al-Motarreb a, M. Al-Habori b, K.J. Broadley c,∗ a Cardiac Centre, Internal Medicine Department, Sana’a University, Sana’a, Yemen b Biochemical Department, Faculty of Medicine, Sana’a University, Sana’a, Yemen c Division of Pharmacology, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, UK article info abstract Article history: The leaves of khat (Catha edulis Forsk.) are chewed as a social habit for the central stimulant action of their Received 9 October 2009 cathinone content. This review summarizes the prevalence of the habit worldwide, the actions, uses, con- Received in revised form 4 June 2010 stituents and adverse health effects of khat chewing. There is growing concern about the health hazards Accepted 1 July 2010 of chronic khat chewing and this review concentrates on the adverse effects on health in the periph- Available online 17 July 2010 eral systems of the body, including the cardiovascular system and gastrointestinal tract. Comparisons are made with amphetamine and ecstasy in particular on the detrimental effects on the cardiovascular Keywords: system. The underlying mechanisms of action of khat and its main constituent, cathinone, on the car- Khat Myocardial infarction diovascular system are discussed. Links have been proposed between khat chewing and the incidence of Hypertension myocardial infarction, dilated cardiomyopathy, vascular disease such as hypertension, cerebrovascular Vasoconstriction ischaemia and thromboembolism, diabetes, sexual dysfunction, duodenal ulcer and hepatitis. -
Analysis of Drugs Manual September 2019
Drug Enforcement Administration Office of Forensic Sciences Analysis of Drugs Manual September 2019 Date Posted: 10/23/2019 Analysis of Drugs Manual Revision: 4 Issue Date: September 5, 2019 Effective Date: September 9, 2019 Approved By: Nelson A. Santos Table of Contents CHAPTER 1 – QUALITY ASSURANCE ......................................................................... 3 CHAPTER 2 – EVIDENCE ANALYSIS ......................................................................... 93 CHAPTER 3 – FIELD ASSISTANCE .......................................................................... 165 CHAPTER 4 – FINGERPRINT AND SPECIAL PROGRAMS ..................................... 179 Appendix 1A – Definitions ........................................................................................... 202 Appendix 1B – Acronyms and Abbreviations .............................................................. 211 Appendix 1C – Instrument Maintenance Schedule ..................................................... 218 Appendix 1D – Color Test Reagent Preparation and Procedures ............................... 224 Appendix 1E – Crystal and Precipitate Test Reagent Preparation and Procedures .... 241 Appendix 1F – Thin Layer Chromatography................................................................ 250 Appendix 1G – Qualitative Method Modifications ........................................................ 254 Appendix 1H – Analytical Supplies and Services ........................................................ 256 Appendix 2A – Random Sampling Procedures -
Chewing Over Khat Prohibition the Globalisation of Control and Regulation of an Ancient Stimulant
Series on Legislative Reform of Drug Policies Nr. 17 January 2012 Chewing over Khat prohibition The globalisation of control and regulation of an ancient stimulant By Axel Klein, Pien Metaal and Martin Jelsma 1 In the context of a fast changing and well documented market in legal highs, the case of khat (Catha edulis) provides an interest- ing anomaly. It is first of all a plant-based substance that undergoes minimal transfor- mation or processing in the journey from farm to market. Secondly, khat has been consumed for hundreds if not thousands of years in the highlands of Eastern Africa and Southern Arabia.2 In European countries, khat use was first observed during the CONCLUSIONS & RECOMMENDATIONS 1980s,3 but has only attracted wider atten- Where khat has been studied exten- tion in recent years. sively, namely Australia, the UK and until Discussions about appropriate regulatory recent-ly the Netherlands, governments systems and the implications of rising khat have steered clear of prohibition because 4 use for European drug policies should take the negative medical and social harms do cognizance of social, demographic and not merit such controls. cultural trends, and compare the existing Strict bans on khat introduced ostensi- models of control that exist in Europe. Khat bly for the protection of immigrant com- provides a unique example of a herbal munities have had severe unintended stimulant that is defined as an ordinary negative consequences. vegetable in some countries and a con- trolled drug in others. It provides a rare Khat prohibition has failed to further the opportunity to study the effectiveness, costs integration, social incusion and economic and benefits of diverse control regimes. -
(Mdma) in Non Conventional Matrices and Its Applications in Clinical Toxicology
Doctoral Thesis Doctorat Farmacología Departament de Farmacología, de Terapéutica i de Toxicologia DISTRIBUTION OF 3,4-METHYLENEDIOXYMETHAMPHETAMINE (MDMA) IN NON CONVENTIONAL MATRICES AND ITS APPLICATIONS IN CLINICAL TOXICOLOGY SIMONA PICHINI p Doctoral Thesis Doctorat Farmacología Departament de Farmacología, de Terapéutica i de Toxicologia DISTRIBUTION OF 3,4-METHYLENEDIOXYMETHAMPHETAMINE (MDMA) IN NON CONVENTIONAL MATRICES AND ITS APPLICATIONS IN CLINICAL TOXICOLOGY Doctoral thesis submitted by Simona Pichini as a partial fulfillment of the requirements for the degree of Doctor by the Universitat Autònoma de Barcelona. The studies included in this thesis have been realized under the direction of Dr. Rafael de la Torre Fornell and Dr. Magí Farré Albaladejo at the Pharmacology Unit of the Institut Municipal d'Investigació Mèdica (IMIM), Barcelona, Spain; and at the Drug Research and Control Department of the Istituto Superiore di Sanità, Roma, Italy. Doctorate Program of the Universitat Autònoma de Barcelona. Signature of Thesis Director Signature of Thesis Director (Dr. Magí Farré Albaladejo) (Dr. Rafael de la Torre Fornell) Signature of Doctorand (Simona Pichini) Yo soy yo y aquéllos a quienes amo Jorge Bucay To my friends, treasure of my life Acknowledgements Acknowledgements A number of people contributed to high extent to achieve the objectives of this Doctoral Thesis prepared between the two cities of Rome and Barcelona. This means that there are many people I’d the opportunity to meet, to work with, to share wonderful and terrible moments, and that I’d like to thank in these pages. First of all, to Dr. Piergiorgio Zuccaro, my “creator”, who always believed in me, supported my job and hardly fought to give me all the possible opportunities to grow up as an investigator; To Dr. -
Methadone Information Your Safety and the Safety of Everyone
Methadone Information Your Safety and the Safety of Everyone Methadone, when taken as prescribed is safe. Methadone taken by any individual it is NOT prescribed to, can be deadly; and when mixed with other drugs, can be deadly; and in the hands of a child, is most certainly deadly. Why? Because it is often difficult to know what other drugs including prescription medications others are being prescribed including herbal/ natural medications; and because unless you are a pharmacist or an experienced physician who is knowledgeable about METHADONE you truly don’t know what will happen when medications are mixed. Treatment Rules and Regulations clearly state: “It is extremely important that medication (this means METHADONE!) be stored in a VERY secure place away from children once the patient takes it to their home. It is not advisable to store the medication in the refrigerator unless it is in a locked, childproof container.” “Patients are not to give away… (Take) home medications (methadone).”It is clearly stated in Rules and Regulations that “Children cannot be held while dosing.” “…The mixing of chemicals may be harmful or fatal.” This is why Locked boxes must meet stringent criteria; to protect you, and those around you. Methadone is a Central Nervous System (CNS) Depressant. This means that Methadone slows down all your central nervous systems including breathing, heart rate, Some medications should NEVER be taken with methadone because they too are CNS depressants. These include alcohol, Benzodiazepines, Naltrexone, Soma, other Opiates and Barbiturates. These drugs taken together potentiate or add to each other: 1+1 no longer = 2; it equals 5 or more If you are a child or anyone the drug is NOT prescribed for you may not know you are in danger as your heart slows, and your breathing becomes shallower and then you die. -
Substance Abuse and Dependence
9 Substance Abuse and Dependence CHAPTER CHAPTER OUTLINE CLASSIFICATION OF SUBSTANCE-RELATED THEORETICAL PERSPECTIVES 310–316 Residential Approaches DISORDERS 291–296 Biological Perspectives Psychodynamic Approaches Substance Abuse and Dependence Learning Perspectives Behavioral Approaches Addiction and Other Forms of Compulsive Cognitive Perspectives Relapse-Prevention Training Behavior Psychodynamic Perspectives SUMMING UP 325–326 Racial and Ethnic Differences in Substance Sociocultural Perspectives Use Disorders TREATMENT OF SUBSTANCE ABUSE Pathways to Drug Dependence AND DEPENDENCE 316–325 DRUGS OF ABUSE 296–310 Biological Approaches Depressants Culturally Sensitive Treatment Stimulants of Alcoholism Hallucinogens Nonprofessional Support Groups TRUTH or FICTION T❑ F❑ Heroin accounts for more deaths “Nothing and Nobody Comes Before than any other drug. (p. 291) T❑ F❑ You cannot be psychologically My Coke” dependent on a drug without also being She had just caught me with cocaine again after I had managed to convince her that physically dependent on it. (p. 295) I hadn’t used in over a month. Of course I had been tooting (snorting) almost every T❑ F❑ More teenagers and young adults die day, but I had managed to cover my tracks a little better than usual. So she said to from alcohol-related motor vehicle accidents me that I was going to have to make a choice—either cocaine or her. Before she than from any other cause. (p. 297) finished the sentence, I knew what was coming, so I told her to think carefully about what she was going to say. It was clear to me that there wasn’t a choice. I love my T❑ F❑ It is safe to let someone who has wife, but I’m not going to choose anything over cocaine. -
Peakal: Protons I Have Known and Loved — Fifty Shades of Grey-Market Spectra
PeakAL: Protons I Have Known and Loved — Fifty shades of grey-market spectra Stephen J. Chapman* and Arabo A. Avanes * Correspondence to: Isomer Design, 4103-210 Victoria St, Toronto, ON, M5B 2R3, Canada. E-mail: [email protected] 1H NMR spectra of 28 alleged psychedelic phenylethanamines from 15 grey-market internet vendors across North America and Europe were acquired and compared. Members from each of the principal phenylethanamine families were analyzed: eleven para- substituted 2,5-dimethoxyphenylethanamines (the 2C and 2C-T series); four para-substituted 3,5-dimethoxyphenylethanamines (mescaline analogues); two β-substituted phenylethanamines; and ten N-substituted phenylethanamines with a 2-methoxybenzyl (NBOMe), 2-hydroxybenzyl (NBOH), or 2,3-methylenedioxybenzyl (NBMD) amine moiety. 1H NMR spectra for some of these compounds have not been previously reported to our knowledge. Others have reported on the composition of “mystery pills,” single-dose formulations obtained from retail shops and websites. We believe this is the first published survey of bulk “research chemicals” marketed and sold as such. Only one analyte was unequivocally misrepresented. This collection of experimentally uniform spectra may help forensic and harm-reduction organizations identify these compounds, some of which appear only sporadically. The complete spectra are provided as supplementary data.[1] Keywords: 1H NMR, drug checking, grey markets, research chemicals, phenylethanamines, N-benzyl phenylethanamines, PiHKAL DOI: http://dx.doi.org/10.16889/isomerdesign-1 Published: 1 August 2015 Version: 1.03 “Once you get a serious spectrum collection, Nevertheless, an inherent weakness of grey markets is the the tendency is to push it as far as you can.”1 absence of regulatory oversight. -
Preventing Alcohol and Other Drug Use in Student-Athletes
Preventing Alcohol and Other Drug Use in Student-Athletes Most Student-Athletes Alcohol Use Don’t Use/Misuse Most don’t misuse alcohol. See percentages of higher risk drinking within the last 12 months.* % of student-athletes reporting “never used” PERCENTAGES OF ALCOHOL USE EFFECTS ON ATHLETIC PERFORMANCE BASED ON AMOUNT 99.6% Heroin • Constricts aerobic metabolism and endurance 99.5% Methamphetamine Division I Division II Division III • Requires increased work to maintain 1.0% 1.6% 1.8% weight 99.1% Anabolic steroids Female • Inhibits absorption of nutrients, More than which then: 98.2% Ultracet, Ultram or Tramadol 4 drinks 38.9% 33.1% 41.2% - Reduces endurance 98.0% Amphetamines 10+ drinks - Decreases protein synthesis for muscle fiber repair 97.4% Human growth hormone (HGH) - Decreases immune response 97.3% Injectable Toradol - Increases risk of injury Male 10.7% 11.5% 15.8% • Alcohol use 24 hours before athletic 97.1% LSD More than activity significantly reduces aerobic 5 drinks 39.0% 38.6% 51.8% performance 96.1% Ecstacy/Molly 10+ drinks • Weekly alcohol consumption 94.5% Cocaine doubles the rate of injury 84.5% ADHD stimulants WITHIN THE 18.2% say they did not drink EFFECTS OF A HANGOVER 83.3% Narcotic pain medication within the last year LAST YEAR, • Increases heart rate HAVE YOU 75.3 % Marijuana • Decreases left ventricular performance EXPERIENCED A • Increases blood pressure 49.0% Tylenol or acetaminophen HANGOVER AS • Decreases endurance performance A CONSEQUENCE • Dehydration 44.6% NSAIDs OF DRINKING ALCOHOL? No: Yes: 19.8% Alcohol 29.8% 52% Marijuana Use Stimulant Use Narcotic Use Most don’t use marijuana. -
Download Full Article As
Article Alkaloids Detection in Commonly Found Medicinal Plants with Marquis Reagent Daniel Alejandro Ocampo-Bustos1 and María Elena Cano-Ruiz1 1 Tecnológico de Monterrey High School, Cuernavaca, Mexico. SUMMARY identity of social groups. Many of the medicinal plants have Alkaloids are a class of nitrogenous organic their healing properties known by empirical use through time, compounds of plant origin that may have important but these medicinal plants may contain active ingredients physiological actions on humans. They include many with tested pharmacological properties. One possibility is that drugs and poisons, but some alkaloids in low doses some of the active ingredients in medicinal plants belong to the have health benefits as well. Traditional medicinal group of alkaloids, which can be determined by a colorimetric plants may contain alkaloids as active ingredients, chemical reaction with the Marquis reagent. The reagent is but this is not well-understood. The Marquis reagent dripped onto the substance being tested, and if an alkaloid exists as a simple qualitative colorimetric method is present, a color change appears (5). The Marquis reagent to determine the presence of alkaloids in medicinal is traditionally composed of a mixture of formaldehyde and plants. The Marquis reagent test was assayed in concentrated sulfuric acid. medicinal plants by first optimizing the formulation Originally, the Marquis reagent was used for testing of the reagent using poppy seeds and lavender as many different alkaloids, and the results from those studies the positive and negative controls. Then using the were the base for developing the color scales that are optimized formulation of Marquis reagent in the extracts of 11 medicinal plants with known claims of used as a reference to determine the specific alkaloid health benefits. -
Opioid Receptorsreceptors
OPIOIDOPIOID RECEPTORSRECEPTORS defined or “classical” types of opioid receptor µ,dk and . Alistair Corbett, Sandy McKnight and Graeme Genes encoding for these receptors have been cloned.5, Henderson 6,7,8 More recently, cDNA encoding an “orphan” receptor Dr Alistair Corbett is Lecturer in the School of was identified which has a high degree of homology to Biological and Biomedical Sciences, Glasgow the “classical” opioid receptors; on structural grounds Caledonian University, Cowcaddens Road, this receptor is an opioid receptor and has been named Glasgow G4 0BA, UK. ORL (opioid receptor-like).9 As would be predicted from 1 Dr Sandy McKnight is Associate Director, Parke- their known abilities to couple through pertussis toxin- Davis Neuroscience Research Centre, sensitive G-proteins, all of the cloned opioid receptors Cambridge University Forvie Site, Robinson possess the same general structure of an extracellular Way, Cambridge CB2 2QB, UK. N-terminal region, seven transmembrane domains and Professor Graeme Henderson is Professor of intracellular C-terminal tail structure. There is Pharmacology and Head of Department, pharmacological evidence for subtypes of each Department of Pharmacology, School of Medical receptor and other types of novel, less well- Sciences, University of Bristol, University Walk, characterised opioid receptors,eliz , , , , have also been Bristol BS8 1TD, UK. postulated. Thes -receptor, however, is no longer regarded as an opioid receptor. Introduction Receptor Subtypes Preparations of the opium poppy papaver somniferum m-Receptor subtypes have been used for many hundreds of years to relieve The MOR-1 gene, encoding for one form of them - pain. In 1803, Sertürner isolated a crystalline sample of receptor, shows approximately 50-70% homology to the main constituent alkaloid, morphine, which was later shown to be almost entirely responsible for the the genes encoding for thedk -(DOR-1), -(KOR-1) and orphan (ORL ) receptors. -
The Renaissance in Psychedelic Research: What Do Preclinical Models Have 2 to Offer
CHAPTER The renaissance in psychedelic research: What do preclinical models have 2 to offer Kevin S. Murnane1 Department of Pharmaceutical Sciences, Mercer University College of Pharmacy, Mercer University Health Sciences Center, Atlanta, GA, United States 1Corresponding author: Tel.: +1-678-547-6290; Fax: +1-678-547-6423, e-mail address: [email protected] Abstract Human research with psychedelics is making groundbreaking discoveries. Psychedelics mod- ify enduring elements of personality and seemingly reduce anxiety, depression, and substance dependence in small but well-designed clinical studies. Psychedelics are advancing through pharmaceutical regulatory systems, and neuroimaging studies have related their extraordinary effects to select brain networks. This field is making significant basic science and translational discoveries, yet preclinical studies have lagged this renaissance in human psychedelic research. Preclinical studies have a lot to offer psychedelic research as they afford tight control of experimental parameters, subjects with documented drug histories, and the capacity to elucidate relevant signaling cascades as well as conduct invasive mechanistic studies of neurochemistry and neural circuits. Safety pharmacology, novel biomarkers, and pharmaco- kinetics can be assessed in disease state models to advance psychedelics toward clinical practice. This chapter documents the current status of psychedelic research, with the thematic argument that new preclinical studies would benefit this field. Keywords Psychedelic, Preclinical, Serotonin, Neuroimaging, Alcoholism, Anxiety, Depression, Substance dependence 1 INTRODUCTION The term psychedelic has come to be associated with a broad class of drugs with diverse chemical, pharmacological, and psychoactive effects. Alternative nomencla- tures have used hallucinogen, entheogen, psychotomimetic and other appellations to Progress in Brain Research, Volume 242, ISSN 0079-6123, https://doi.org/10.1016/bs.pbr.2018.08.003 25 © 2018 Elsevier B.V.