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ANNUAL REPORT 2019 1 Contents Director’S Letter 1
Whitehead Institute ANNUAL REPORT 2019 1 Contents Director’s Letter 1 Chair’s Letter 3 Members & Fellows 4–5 Science 6 Community 44 Philanthropy 56 2 The Changing Face of Discovery For 37 years, Whitehead Institute has demonstrated an ability to drive scientific discovery and to chart paths into new frontiers of knowledge. Its continuing achievements are due, in substan- tial part, to the unique capacities and dedication of Members who joined the Institute in the 1980s and ‘90s — from Founding Members Gerald Fink, Harvey Lodish, Rudolf Jaenisch, and Robert Weinberg to those who followed, including David Bartel, David Sabatini, Hazel Sive, Terry Orr-Weaver, Richard Young, and me. Those long-serving Members continue to do pioneering science and to be committed teachers and mentors. Yet we have begun an inevitable genera- tional transition: In the last two years, Gerry and Terry have closed their labs, and Harvey will do so this coming year. The exigencies of time mean that, increasingly, Whitehead Institute’s ability to maintain its vigorous scientific leadership depends on our next generation of researchers. As I move toward the conclusion of my term as director, I am particularly proud of the seven current Members and the 14 Whitehead Institute Fellows we recruited during the last 16 years. The newest of those stellar researchers joined us in 2019: Whitehead Institute Member Pulin Li and Whitehead Fellow Kipp Weiskopf. Pulin studies how circuits of interacting genes in individu- al cells enable multicellular functions, such as self-organizing into complex tissues, and her research brilliantly combines approaches from synthetic biology, developmental and stem cell biology, biophysics, and bioengineering to study these multicellular behaviors. -
49 Annual Drosophila Research Conference • Program and Abstracts
49 th Annual Drosophila Research Conference • Program and Abstracts Conference • Program Research Annual Drosophila The Genetics Society of America 9650 Rockville Pike, Bethesda, MD 20814-3998 Telephone: 301/634-7300 • Fax: 301/634-7079 e-mail: [email protected] Web site: www.genetics-gsa.org Conference site: www.drosophila-conf.org 49TH ANNUAL DROSOPHILA RESEARCH CONFERENCE April 2–6, 2008 Town and Country Hotel & Conference Center San Diego, California Program and Abstracts Volume • 2008 Meeting Organizers Nancy Bonini, University of Pennsylvania Susan Celniker, Lawrence Berkeley National Laboratory Brian Oliver, NIDDK, NIH, HHS John Tamkun, University of California, Santa Cruz • 2007/2008 Drosophila Board of Directors Officers and Regional Representatives* President Utpal Banerjee University of California, Los Angeles President-Elect Carl Thummel University of Utah Past-President Trudy MacKay North Carolina State University Past-President & Elections Chair Mark Krasnow Stanford University Past-President Lynn Cooley Yale University Treasurer Michael Bender University of Georgia Canada Howard Lipshitz University of Toronto Great Lakes Amanda Simcox Ohio State University Northwest Jim Truman University of Washington Southeast Rebecca Kellum University of Kentucky California Graeme Davis University of California, San Francisco Heartland Susan Abmayr Stowers Institute for Medical Research New England Mitzi Kuroda Harvard University Medical School Mid-Atlantic Liz Gavis Princeton University Midwest Pam Geyer University of Iowa • International Representatives Australia/Oceana Phil Batterham University of Melbourne Asia Vijay Raghavan The National Centre for Biological Sciences Europe Barry Dickson Research Institute of Molecular Pathology *2008/2009 Board of Directors will be listed in the Program Addendum and take office following the 2008 Drosophila Research Conference. -
Cold Spring Harbor Laboratory Annual
COLD SPRING HARBOR LABORATORY ;44 ANNUAL REPORT 1975 Cover: Ruffling lamellipodium and several filopodia extending from a 3T3 mouse fibroblast 15 minutes after plating on a glass substratum. Scanning electron micros- copy; horizontal magnification, 31,500 x. (Photo by G. Albrecht-Buehler) ANNUAL REPORT 1975 COLD SPRING HARBOR LABORATORY COLD SPRING HARBOR, NEW YORK COLD SPRING HARBOR LABORATORY Cold Spring Harbor, Long Island, New York OFFICERS OF THE CORPORATION Chairman: Dr. Harry Eagle Treasurer: Angus P. McIntyre Vice Chairman: Edward Pulling Assistant Secretary-Treasurer: Secretary: Mrs. George Lindsay William R. Udry Laboratory Director:Dr.James D. Watson Administrative Director: William R. Udry BOARD OF TRUSTEES INSTITUTIONAL TRUSTEES Albert Einstein College of Medicine Princeton University Dr. Harry Eagle Dr. Bruce Alberts Columbia University The Rockefeller University Dr. Sherman Beychok Dr. Rollin Hotchkiss Duke University Sloan-Kettering Institute Dr. Robert E. Webster Dr. Lewis Thomas Harvard University State University of New York, School of Public Health Stony Brook Dr. Howard Hiatt Dr. Joseph R. Kates Long Island Biological Association University of Wisconsin Edward Pulling Dr. William Dove Massachusetts Institute of Technology Wawepex Society Dr. Herman Eisen Townsend J. Knight New York University Medical Center Dr. Vittorio Defendi INDIVIDUAL TRUSTEES Clarence E. Galston Colton P. Wagner Dr. David P. Jacobus Mrs. Alex M. White Mrs. George N. Lindsay William A. Woodcock Angus P. McIntyre Dr. James D. Watson Walter H. Page Honorary Trustees: Charles Robertson Dr. Alexander Hollaender Arthur D. Trottenberg Dr. H. Bentley Glass Officers and Trustees listed are as of October 31, 1975. DIRECTOR’S REPORT No one can do first-rate science without possessing a deep sense of curiosity. -
ANIMUA Pat 022
ANIMUA PaT 022 COLD SPRING HARBOR LABORATORY ANNUAL REPORT 1992 Cold Spring Harbor Laboratory Box 100 1 Bungtown Road Cold Spring Harbor, New York 11724 Book design Emily Harste Managing Editor Susan Cooper Editor Dorothy Brown Photography Margot Bennett, Herb Parsons, Edward Campodonico, Scott McBride, Julie Timmins Typography Marie Sullivan Front cover: Blackford Hall (Renovated 1992) (Photographby Margot Bennett) Back cover: Aerial view of Cold Spring HarborLaboratory (Photog- raph by Margot Bennett) Contents Officers of the Corporation/Board of Trustees v Governance and Major Affiliations vi Committeesvii Barbara McClintock (1902-1992) viii Taggert Whipple (1912-1992) xii DIRECTOR'S REPORT 1 DEPARTMENTAL REPORTS 23 Administration 25 Buildings and Grounds 28 Development 30 Library Services 34 Public Affairs 36 RESEARCH 41 Tumor Viruses43 Molecular Genetics of Eukaryotic Cells 85 Genetics 151 Structure and Computation 199 Neuroscience 227 CSH Laboratory Fellows249 Author Index253 COLD SPRING HARBOR MEETINGS 255 Symposium on Quantitative Biology259 Meetings263 EDUCATIONAL ACTIVITIES 289 Postgraduate Courses 291 Seminars325 Undergraduate Research327 Nature Study329 BANBURY CENTER 331 Director's Report333 Meetings 341 DNA LEARNING CENTER 371 COLD SPRING HARBOR LABORATORY PRESS 395 FINANCIAL STATEMENTS 401 FINANCIAL SUPPORT OF THE LABORATORY 407 Grants 409 Corporate Sponsor Program416 Capital Gifts417 Annual Contributions 421 Cold Spring Harbor Laboratory Association422 LABORATORY STAFF 431 Front row: D.L. Luke III, M.F. Gerry, T.J. Knight, J.D. Watson, B.D. Clarkson, M.D. Lindsay, L.J. Landeau Second row: W. Everdell, E.S. Marks, W.R. Miller, C.F. Dolan, S.M.C. Tilghman, G.R. Fink Third row: D.B. Pall, T.M. Jessell, T. -
Appendix a National Science Board DAVID M
LLOYD hf. COOICE,Director of Urban Affair& National Science Board, NSF Union Carbide Corp., New York, N.Y. Staff, Advisory Committees *ROBERT H. DICILE, Cyrus Fogg Brackett Profeseor of Physic% Department of and Panels Physics, Princeton University, Prince- ton, N.J. Appendix A National Science Board DAVID M. GATJES,Professor of Botany and Director, Biological Station, Department Terms Expire May lo,1972 of Botany, University of Michigan, Ann CH- F. JONES, Vice Chairman of the Arbor, Mich. Board, Humble Oil & Refining Co., How *RICER W. HEYNS (Vice Chairman, Na- ton, Tex. tional Science Board) , Professor of PSY THOMAS F. JONES, Jr., President, University chology and Education, Department of of South Carolina, Columbia, S.C. Psychology, University of Michigan, Ann ROBERT S. MORRISON, Professor of Science Arbor, Mich. and Society, Program on Science, Tech- FRANK PRESS, Chairman, Department of nology, and Society, Cornell University, Earth and Planetary Sciences,Massachu- Ithaca, N.Y. setts Institute of Technology,.. Cambridge, E. R. PIORE, Vice President and Chief Scien- Mass. tist, International Business Machined *F. P. THIEME, President, University of Corp., Armonk, N.Y. Colorado, Boulder, Colo. JOSEPH M. REYNOLDG, Boyd Professor of Member Ex Odlfcio Physics and Vice President for Inatruc- +W. D. MCELROY, Director, National Sd- tion and Research, Louisiana State Uni- ence Foundation, Washington, D.C. versity, Baton Rouge, La. (Chairman, Executive Committee) ATHEUTAN F. SPILHAIJS, Fellow, Woodrow Wilson International Center for Scholars, + l + Smithsonian Institution, Washington, VERNICE ANDERSON, Executive Secretary, Na- D.C. tional Science Board, National Science H. GUYFORD STEVE& President, Carnegie- Foundation, Washington, D.C. Mellon University, Pittsburgh, Pa. -
Frontiers in Science
MBL Non-profit Org. U.S. Postage Biological Discovery in Woods Hole Biological Discovery in Woods PAID Plymouth, MA Permit # 55 MBL 7 MBL Street Woods Hole, MA 02543 • Frontiers in Science A NNUAL R EPORT 2007 EPORT ANNUAL REPORT 2007 Founded in 1888 as the Marine Biological Laboratory About the cover: Live endothelial cell spreading on a glass surface. Birefringence image recorded with the LC-PolScope, a microscopy technique invented at the MBL (see page 12-13). Image brightness corresponds to magnitude, color to orientation of birefringence (no stains or labels were applied to the cell.) Credit: K. Patel. The Marine Biological Laboratory does not discriminate in employment or in access to any of its The MBL Annual Report is published by the activities or programs or take any retaliatory action on the basis of race, color, religion, sex, sexual Marine Biological Laboratory. Although the orientation, national origin, ancestry, age, marital status, pregnancy, physical or mental disability, greatest possible care has been taken in the veteran status or genetic predisposition. In addition, the MBL is committed to the prevention and preparation of this record, the MBL recognizes elimination of sexual harassment, as well as other forms of unlawful harassment, in the workplace. the possibility of omissions or inaccuracies. If Through training programs and disseminated information, MBL strives to educate its employees, any are noted, please accept our apology and students, faculty, and visitors on these important issues. advise us of any corrections -
Meeting Global Challenges: Discovery and Innovation
Meeting Global Challenges: Discovery and Innovation AAAS ANNUAL REPORT 2014 The American Association for the Advancement of Science (AAAS) is the world’s largest general scienti c society and publisher of the journal Science (www.sciencemag.org) as well as Science Translational Medicine (www.sciencetranslationalmedicine.org), Science Signaling (www.sciencesignaling.org), and a digital, open-access journal, Science Advances (www.scienceadvances.org). AAAS was founded in 1848 and includes nearly 250 a liated societies and academies of science, serving 10 million individuals. Science has the largest paid circulation of any peer-reviewed general science journal in the world. The non-pro t AAAS (www.aaas.org) is open to all and ful lls its mission to “advance science and serve society” through initiatives in science policy, international programs, science education, public engagement, and more. For the latest research news, log onto EurekAlert!, www.eurekalert.org, the premier science-news Web site, a service of AAAS. See www.aaas.org. American Association for the Advancement of Science 1200 New York Avenue, NW • Washington, DC 20005 USA Tel: 202-326-6440 For more information about supporting AAAS, please e-mail developmento [email protected], or call 202-326-6636. On the Cover: As it takes flight in Kenya, this Eurasian roller (Coracias garrulous), with its magni cent blue and teal-colored wings, o ers a reminder of the promise of discovery and innovation for improving human welfare. Alan I. Leshner, AAAS CEO emeritus, captured this photograph in early 2015. Table of Contents Welcome Letter by Phillip A. Sharp and Rush D. Holt ..................... -
Ar-2018-Web.Pdf
Whitehead Institute ANNUAL REPORT 2018 3 4 Paradigm-shifting scientific achievement through a deeply collaborative culture and the pursuit of bold, creative inquiry Contents Director’s Letter 3 Chair’s Letter 5 Members & Fellows 6 Science 8 Education 48 Community 58 2 The Energy of a Scientific Community Each fall, Whitehead Institute holds its annual Scientific Retreat. It is an opportunity for our community to discuss the questions we are pursuing and the most recent fruits of those investigations. Virtually everyone attends — Members and Fellows, senior scientists and postdocs, operational and technical staff, and graduate students. Three days of scientific talks and poster sessions prompt deep and wide-ranging conversations — discussions that frequently yield “aha” moments of unanticipated connection and opportunities for partnership. Almost as important, there is laughter, there are conversations about books we’ve read and the families we’re nurturing, and Saturday night brings dancing into the small hours. The Retreat is a key to the sense of community and collaborative spirit that are hallmarks of the Institute’s culture. It is also a potent reminder that our people are the beating heart of our organization. State-of-the-art laboratories and technical facilities are crucial to advancing science. But it is human intellect, curiosity, passion, and resilience that truly move science forward. Our scientists — the unique intellectual engine they collectively constitute — make Whitehead Institute such a special place. I was particularly conscious of this fact during this year’s Scientific Retreat, because it was backgrounded by the ongoing recruitment and welcoming of new faculty and Whitehead Fellows. -
2010-11 Archived Seminars 8/14/14 12:43 PM
2010-11 Archived Seminars 8/14/14 12:43 PM A Cornell University • Deparhnent of :tvlolecular Biology and Genetics 2010-11 Archived Seminars June 3, 2011 Ailong Ke Department of Molecular Biology & Genetics Cornell University Title: "Ligand-sensing and oligomerization mechanisms in RNA" Host: Ken Kemphues http://gradeducation.lifesciences.cornell.edu/faculty/individual15976 May 20, 2011 Victor Ambros Graduate School of Biomedical Biomedical Sciences University of Massachusetts, Worcester Title: "MicroRNA pathways in animal development" Host: Ken Kemphues http://www.umassmed.edu/igp/faculty/Ambros.cfm May 13, 2011 Helen Salz Department of Genetics, School of Medicine Case Western Reserve University, Cleveland Ohio Title: "Sex Determination in Drosophila: a binary decision based on alternative splicing" Host: Mariana Wolfner http://genetics.case.edu/?page_id=5&LN=Salz&FN=Helen May 6, 2011 Abby Dernburg HHMI, Department of Molecular & Cell Biology University of California, Berkeley Title: "Chromonsone Choreography during meiosis" Host: Eric Alani http://mcb.berkeley.edu/index.php?option=com_mcbfaculty&name=dernburga April 29, 2011 Philip Cole Department of Pharmacology John Hopkins University Title: "Chemicalapproaches to sorting out protein Kinases" Host: Hening Lin http://www.hopkinsmedicine.org/institute_basic_biomedical_sciences/research/nih_initiatives/technology_center_networks_pathways/investigators/cole.html April 22, 2011 Speaker- Terry Magnuson Department of Genetics University of North Carolina, School of Medicine Title: "X Chromosome Inactivation: A Model System for Mammalian Epigenetic Processes" Host: John Schimenti http://genetics.unc.edu/faculty/magnuson April 15, 2011 http://mbg.cornell.edu/cals/mbg/about/seminars/archived-seminars/2010-11archive.cfm Page 1 of 6 2010-11 Archived Seminars 8/14/14 12:43 PM David Jameson Department of Cell & Molecular Biology University of Hawaii at Manoa, John A.