PE1348 Your Scar After Heart Surgery
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A Review of the Evidence for and Against a Role for Mast Cells in Cutaneous Scarring and Fibrosis
International Journal of Molecular Sciences Review A Review of the Evidence for and against a Role for Mast Cells in Cutaneous Scarring and Fibrosis Traci A. Wilgus 1,*, Sara Ud-Din 2 and Ardeshir Bayat 2,3 1 Department of Pathology, Ohio State University, Columbus, OH 43210, USA 2 Centre for Dermatology Research, NIHR Manchester Biomedical Research Centre, Plastic and Reconstructive Surgery Research, University of Manchester, Manchester M13 9PT, UK; [email protected] (S.U.-D.); [email protected] (A.B.) 3 MRC-SA Wound Healing Unit, Division of Dermatology, University of Cape Town, Observatory, Cape Town 7945, South Africa * Correspondence: [email protected]; Tel.: +1-614-366-8526 Received: 1 October 2020; Accepted: 12 December 2020; Published: 18 December 2020 Abstract: Scars are generated in mature skin as a result of the normal repair process, but the replacement of normal tissue with scar tissue can lead to biomechanical and functional deficiencies in the skin as well as psychological and social issues for patients that negatively affect quality of life. Abnormal scars, such as hypertrophic scars and keloids, and cutaneous fibrosis that develops in diseases such as systemic sclerosis and graft-versus-host disease can be even more challenging for patients. There is a large body of literature suggesting that inflammation promotes the deposition of scar tissue by fibroblasts. Mast cells represent one inflammatory cell type in particular that has been implicated in skin scarring and fibrosis. Most published studies in this area support a pro-fibrotic role for mast cells in the skin, as many mast cell-derived mediators stimulate fibroblast activity and studies generally indicate higher numbers of mast cells and/or mast cell activation in scars and fibrotic skin. -
EMBRACE YOUR SCARS a SCAR Is Your Skin’S Natural Way of Knitting Itself Back Worry About Scars? Together After It’S Been Hurt
ASK THE Experts own skin. We asked two of our Skin Cancer Founda- Mohs surgery on certain cases of melanoma, but tion member physicians to share their expertise on this requires additional training. Patients with more Healing everything you need to know to be scar-savvy, from advanced melanomas may require additional treat- wound care to scar repair. ments, such as radiation or medications, including immunotherapies and targeted therapies. What is a scar, exactly? How much do patients EMBRACE YOUR SCARS A SCAR is your skin’s natural way of knitting itself back worry about scars? together after it’s been hurt. Healing is a multipart pro- If you have a scar, congratulations! Think of it as a badge of courage and healing. cess, and the science behind it is complex. Dermatolog- WHEN DOCTORS tell patients they need skin cancer Our expert dermatologists tell how to nurture a new scar to get the ic surgeon Mary-Margaret Kober, MD, who practices surgery, they hear a wide range of reactions, says Dr. in Santa Rosa, California, helps explain it in simple Kober. “I have some patients who say, ‘I don’t care best outcome — and, if needed, how to fix an old scar to make it look better. terms. Wherever there’s been an injury, she says, the about the scar, Doc. I don’t have a modeling career. by Julie Bain first thing that happens is that blood cells called plate- Just get the cancer out.’ That’s one extreme.” There lets gather together and form a clot to stop the bleed- are also patients on the other side of the spectrum, ing and seal the wound. -
Sunday, 11 April 2021 John 20:19-31 Pr Gus Schutz 'Then He Said
Sunday, 11 April 2021 John 20:19-31 Pr Gus Schutz ‘Then he said to Thomas, “Put your finger here; see my hands. Reach out your hand and put it into my side. Stop doubting and believe.”’ The scars of Jesus were very important for Thomas. It can be easy to be a little hard on Thomas. I think tradition has done that. Put yourself in his situation. Wouldn’t you also want some visible proof to connect what you see with the events of Good Friday? So that you can know without doubt that this really is the same Jesus who was hung up on the cross? The truth is the scars of Jesus were important for all the disciples. They confirmed to them that it truly was Jesus. In the same body, now risen and transformed. • When Jesus first appeared to the disciples, Luke tells us: “they were startled and frightened and thought they saw a spirit.” (Luke 24:37) Then he showed them his scars, saying to them: “Look at my hands and my feet. It is I myself! Touch me and see; a ghost does not have flesh and bones, as you see I have.” (Luke 24:39) • The apostle John reports that Jesus: “showed them his hands and feet” (John 20:20) This was the first time, when Thomas was not with them. So he insisted he must see the scars when it was reported to him that the others had seen Jesus. Eight days later the wish and prayer of Thomas was answered. Jesus offered him his scars, saying: “Put your finger here; see my hands. -
Fundamentals of Dermatology Describing Rashes and Lesions
Dermatology for the Non-Dermatologist May 30 – June 3, 2018 - 1 - Fundamentals of Dermatology Describing Rashes and Lesions History remains ESSENTIAL to establish diagnosis – duration, treatments, prior history of skin conditions, drug use, systemic illness, etc., etc. Historical characteristics of lesions and rashes are also key elements of the description. Painful vs. painless? Pruritic? Burning sensation? Key descriptive elements – 1- definition and morphology of the lesion, 2- location and the extent of the disease. DEFINITIONS: Atrophy: Thinning of the epidermis and/or dermis causing a shiny appearance or fine wrinkling and/or depression of the skin (common causes: steroids, sudden weight gain, “stretch marks”) Bulla: Circumscribed superficial collection of fluid below or within the epidermis > 5mm (if <5mm vesicle), may be formed by the coalescence of vesicles (blister) Burrow: A linear, “threadlike” elevation of the skin, typically a few millimeters long. (scabies) Comedo: A plugged sebaceous follicle, such as closed (whitehead) & open comedones (blackhead) in acne Crust: Dried residue of serum, blood or pus (scab) Cyst: A circumscribed, usually slightly compressible, round, walled lesion, below the epidermis, may be filled with fluid or semi-solid material (sebaceous cyst, cystic acne) Dermatitis: nonspecific term for inflammation of the skin (many possible causes); may be a specific condition, e.g. atopic dermatitis Eczema: a generic term for acute or chronic inflammatory conditions of the skin. Typically appears erythematous, -
Advances in Seborrheic Keratosis
A CME/CE-Certified Supplement to Original Release Date: December 2018 Advances in Seborrheic Expiration Date: December 31, 2020 Estimated Time To Complete Activity: 1 hour Participants should read the activity information, Keratosis review the activity in its entirety, and complete the online post-test and evaluation. Upon completing this activity as designed and achieving a passing score on FACULTY the post-test, you will be directed to a Web page that will Joseph F. Fowler Jr, MD Michael S. Kaminer, MD allow you to receive your certificate of credit via e-mail Clinical Professor and Director Associate Clinical Professor of Dermatology or you may print it out at that time. Contact and Occupational Yale Medical School The online post-test and evaluation can be accessed Dermatology New Haven, Connecticut at http://tinyurl.com/SebK2018. University of Louisville School of Adjunct Assistant Professor of Medicine Medicine (Dermatology), Warren Alpert Medical School Inquiries about continuing medical education (CME) Louisville, Kentucky of Brown University accreditation may be directed to the University of Providence, Rhode Island Louisville Office of Continuing Medical Education & Professional Development (CME & PD) at cmepd@ louisville.edu or (502) 852-5329. Designation Statement eborrheic keratosis (SK) has been called keratinizing surface.12 They can develop virtually The University of Louisville School of Medicine the “Rodney Dangerfield of skin lesions”— anywhere except for the palms, soles, and mucous designates this Enduring material for a maximum of 9 1.0 AMA PRA Category 1 Credit(s)™. Physicians should it earns little respect (as a clinical concern) membranes, but are most commonly observed claim only the credit commensurate with the extent of Sbecause of its benignity, commonality, usual on the trunk and face.6,13 The tendency to develop their participation in the activity. -
Linear Scleroderma “En Coup De Sabre” Coexisting with Plaque-Morphea
661 J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.74.5.661 on 1 May 2003. Downloaded from SHORT REPORT Linear scleroderma “en coup de sabre” coexisting with plaque-morphea: neuroradiological manifestation and response to corticosteroids I Unterberger, E Trinka, K Engelhardt, A Muigg, P Eller, M Wagner, N Sepp, G Bauer ............................................................................................................................. J Neurol Neurosurg Psychiatry 2003;74:661–664 progression of skin lesions or any neurological abnormalities A 24 year old woman in the 33rd week of pregnancy during follow up. developed progressive neurological complications with On admission the patient was in the 33rd week of right sided hemiparesis in association with the occurrence pregnancy. She was fully oriented, had normal speech, and of linear scleroderma “en coup de sabre” (LSCS) and pre- presented with a right sided hemiparesis (grade 3/5, MRC existing plaque-morphea, already being treated by scale) with a positive Babinski sign on the right. There was no balneophototherapy. Further progression of neurological history of head trauma. symptoms led to a caesarean section with the delivery of a Routine laboratory testing and comprehensive serological healthy child. Brain magnetic resonance imaging (MRI) screening including antineutrophilic cytoplasmic antibodies showed focal T2 signal increases in the left frontoparietal (ANCA), anticardiolipin antibodies, and antibodies against region directly adjacent to the area of LSCS. -
How to Avoid Training Scars by CHRISTOPHER BRENNAN
Continuing Education Course How to Avoid Training Scars BY CHRISTOPHER BRENNAN TRAINING THE FIRE SERVICE FOR 136 YEARS To earn continuing education credits, you must successfully complete the course examination. The cost for this CE exam is $25.00. For group rates, call (973) 251-5055. AVOIDING TRAINING SCARS ● methodology was Donald Meichenbaum, who initially “fo- ally five or 10 push-ups. The initial time standards are very How to Avoid cused on cognitive-emotional theory of anxiety and learning generous, 90 seconds or so, to train the student to handle the approaches for the development of cognitive and relaxation stress. We could, of course, make the initial time standard 60 coping skills for anxiety reduction.”1 Survival skills instruc- seconds (which is the minimum passing time), but then there tors have used variations on SIT from the days of ancient would be a lot of push-ups done and a great increase in anxi- warrior cultures without having a specific label for it. ety. Once we warm the group up with a few 90-second drills Training Scars From the brutal rites of passage that are part of initiation (which generally everyone passes), we can then slowly work into elite military organizations through the burn tower evo- our way toward the 60-second mark. As the time standard lutions with recruit academy candidates to law enforcement gets closer to the neurological skill capacity of the students, defensive tactics courses, those who are expected to place their anxiety will increase (they don’t want to do push-ups). their bodies in harm’s way have attempted from time imme- We coach them to control their breathing and focus on their morial to develop a mental toughness in their students. -
How to Know If You're Dead
How to Know If You're Dead Beating-heart cadavers, live burial, and the scientific search for the soul A patient on the way to surgery travels at twice the speed of a patient on the way to the morgue. Gurneys that ferry the living through hospital corridors move forward in an aura of purpose and push, flanked by caregivers with long strides and set faces, steadying IVs, pumping ambu bags, barreling into double doors. A gurney with a cadaver commands no urgency. It is wheeled by a single person, calmly and with little notice, like a shopping cart. For this reason, I thought I would be able to tell when the dead woman was wheeled past. I have been standing around at the nurses' station on one of the surgery floors of the University of California at San Francisco Medical Center, watching gurneys go by and waiting for Von Peterson, public affairs manager of the California Transplant Donor Network, and a cadaver I will call H. "There's your patient," says the charge nurse. A commotion of turquoise legs passes with unexpected forward-leaning urgency. H is unique in that she is both a dead person and a patient on the way to surgery. She is what's known as a "beating-heart cadaver," alive and well everywhere but her brain. Up until artificial respiration was developed, there was no such entity; without a functioning brain, a body will not breathe on its own. But hook it up to a respirator and its heart will beat, and the rest of its organs will, for a matter of days, continue to thrive. -
Nodular Morphea
Case Report Dermatology 2009;218:63–66 Received: July 13, 2008 DOI: 10.1159/000173976 Accepted: July 23, 2008 Published online: November 13, 2008 Nodular Morphea a b c F. Kauer J.C. Simon M. Sticherling a b Department of Dermatology and Venerology, Vivantes Klinikum Neukölln, Berlin , Department of Dermatology, c Venerology and Allergology, University of Leipzig, Leipzig , and Department of Dermatology, Venerology and Allergology, University of Erlangen, Erlangen , Germany Key Words can range in size from 2 mm to 4–5 cm, flamed skin that is already involved in an -Scleroderma ؒ Keloid ؒ Hypertrophic scar ؒ usually appear spontaneously and tend to active fibrotic process inherent to the dis Morphea involve the trunk and upper extremities. ease in those patients who are genetically A linear presentation has also been de- predisposed to keloid development, or at scribed. The literature on this topic is con- sites of the skin that show a high predilec- Abstract fusing because the terms ‘nodular sclero- tion for keloid formation, such as the trunk Scleroderma may present as being strictly derma’ and ‘keloidal scleroderma’ are used [6, 7] . limited to the skin, as in morphea, or within interchangeably even though there is a a multiorgan disease, as in systemic sclero- great degree of variability in the histologi- sis. Accordingly, cutaneous manifestations cal findings of these nodules [4] . In con- C a s e R e p o r t vary clinically. In nodular or keloidal sclero- trast, other authors stress that the cutane- derma, patients develop lesions that are ous manifestations may vary clinically, but Medical History clinically indistinguishable from a keloid; all share the same histopathological pat- A 16-year-old girl presented with mul- however, the histopathological findings are tern of both morphea/scleroderma and ke- tiple progressive morpheic skin lesions more variable. -
40Th Anniversary Primer
200040TH ANNIVERSARY AD PRIMER 40TH INSERT.indd 1 07/02/2017 15:28 JUDGE DREDD FACT-FILE First appearance: 2000 AD Prog 2 (1977) Created by: John Wagner and Carlos Ezquerra ////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////// Judge Dredd is a totalitarian cop in Mega- Blue in a sprawling ensemble-led police an awful lot of blood in his time. City One, the vast, crime-ridden American procedural about Dredd cleaning up crime East Coast megalopolis of over 72 million and corruption in the deadly Sector 301. With stories such as A History of Violence people set 122 years in the future. Judges and Button Man, plus your hard-boiled possess draconian powers that make them Mega-City Undercover Vols. 1-3 action heroes like Dredd and One-Eyed judge, jury, and executioner – allowing them Get to know the dark underbelly of policing Jack, your love of crime fiction is obvious. to summarily execute criminals or arrest Mega-City One with Justice Department’s Has this grown over the years? What citizens for the smallest of crimes. undercover division. Includes Andy Diggle writers have influenced you? and Jock’s smooth operator Lenny Zero, and Created by John Wagner and Carlos Ezquerra Rob Williams, Henry Flint, Rufus Dayglo and JW: I go through phases. Over the past few in 1977, Dredd is 2000 AD’s longest- D’Israeli’s gritty Low Life. years I have read a lot of crime fiction, running character. Part dystopian science enjoyed some, disliked much. I wouldn’t like fiction, part satirical black comedy, part DREDD: Urban Warfare to pick any prose writer out as an influence. -
Breaking Intergenerational Cycles of Repetition. a Global Dialogue on Historical Trauma and Memory
Breaking Intergenerational Cycles of Repetition Pumla Gobodo-Madikizela (ed.) Breaking Intergenerational Cycles of Repetition A Global Dialogue on Historical Trauma and Memory Barbara Budrich Publishers Opladen • Berlin • Toronto 2016 An electronic version of this book is freely available, thanks to the support of libraries working with Knowledge Unlatched. KU is a collaborative initiative designed to make high quality books Open Access for the public good. The Open Access ISBN for this book is 978-3-8474-0240-4. More information about the initiative and links to the Open Access version can be found at www.knowledgeunlatched.org © 2016 This work is licensed under the Creative Commons Attribution-ShareAlike 4.0. (CC- BY-SA 4.0) It permits use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you share under the same license, give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. To view a copy of this license, visit https://creativecommons.org/licenses/by-sa/4.0/ © 2016 Dieses Werk ist beim Verlag Barbara Budrich GmbH erschienen und steht unter der Creative Commons Lizenz Attribution-ShareAlike 4.0 International (CC BY-SA 4.0): https://creativecommons.org/licenses/by-sa/4.0/ Diese Lizenz erlaubt die Verbreitung, Speicherung, Vervielfältigung und Bearbeitung bei Verwendung der gleichen CC-BY-SA 4.0-Lizenz und unter Angabe der UrheberInnen, Rechte, Änderungen und verwendeten Lizenz. This book is available as a free download from www.barbara-budrich.net (https://doi.org/10.3224/84740613). -
The Stars and Scars of Christmas SERMON REFERENCE
SERMON TITLE: The Stars and Scars of Christmas SERMON REFERENCE: John 20:24-29 LWF SERMON NUMBER: #2452 We are grateful for the opportunity to provide this transcript produced from a live sermon preached by Adrian Rogers while serving as pastor of Bellevue Baptist Church in Memphis, Tennessee. This transcript is intended for your personal, non-commercial use. Note: Though it has been transcribed from a version used for broadcast, it may contain stutters, stammers, and other authentic remarks as would be common in a live setting. In order to ensure our ability to be good stewards of Adrian Rogers’ messages, Love Worth Finding has reserved all rights to this content. Except for your personal, non-commercial use and except for brief quotations in printed reviews, no part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means —electronic, mechanical, photocopy, recording, or any other— without the prior permission of the publisher. Copyright ©2020 Love Worth Finding Ministries, Inc. Transcripts are used by permission of the Rogers Family Trust. PO Box 38300 | Memphis TN 38183-0300 | (901) 382-7900 lwf.org THE STARS AND SCARS OF CHRISTMAS | JOHN 20:24-29 | #2452 Be finding in God’s Word John chapter 20. I’m going to give you a test. Are you ready for the test? This is Theology 101. Are you ready? One question on the test: Is Jesus God or man? Alright, the answer to that question is yes. He is the God-man, God in human flesh. The prophet Isaiah said in Isaiah 9 verse 6, “Unto us a child is born and unto us a Son is given.” When Isaiah said, “a child is born,” he was speaking of His humanity.