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Stratamark Is Clinically Proven to Prevent and Treat Stretch Marks

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Stratamark Is Clinically Proven to Prevent and Treat Stretch Marks Stratamark is clinically proven to prevent and treat stretch marks • Over 500 pregnant women have participated in clinical studies with Stratamark.10,11 • Stratamark is suitable for pregnant women, breastfeeding mothers, children and people with sensitive skin.10,11 The breakthrough medical product for the prevention and treatment of stretch marks • Softens and flattens raised and depressed stretch marks Prevention studies Treatment studies • Reduces redness and discoloration of stretch marks The breakthrough Stratamark group • Relieves itching and discomfort of stretch marks • Suitable for pregnant women, breastfeeding mothers, medical product for children and people with sensitive skin the prevention and 80% of women demonstrated a significant level of improvement in treatment of 18.2% their stretch marks Stratamed and Strataderm help mothers to get the best possible scar outcome after a caesarean section. stretch marks Control group 91% of patients rated the ease of use of Stratamark 60–70% very good - excellent 90% of patients rated the efficacy of use 81.8% of Stratamark did not develop www.stratamed.com www.strataderm.com very good - excellent stretch marks10 Stratamed promotes faster wound healing Strataderm – for the professional treatment and prevents abnormal scarring. of scars both old and new. 87% During wound healing After wound healing (suture removal) of patients rated • Promotes faster wound healing by creating • For effective management of abnormal and Incidence of the feeling on Striae -43% a moist wound healing environment excessive scar formation p < 0.001 the skin to be 80% • Suitable for breastfeeding mothers very good - excellent • Suitable for breastfeeding mothers 60% 40% 61 % 66% of patients in the www.stratamark.net 20% treatment group reduced the severity References: 1. Viennet C, Bride J, Armbruster V et al. Contractile forces generated by striae distensae fibroblasts embedded in collagen lattices. Arch Dermatol Res. 2005;297(1):10-17. doi:10.1007/s00403-005-0557-9. 2. 0 % Rotsztejn H et al. Advances in Medical Sciences 2010; 55 Rotsztejn H, Juchniewicz B, Nadolski M, Wendorff J, Kamer B. The unusually large striae distensae all over the body. Adv Med Sci. 2010;55(2):343-345. doi:10.2478/ v10039-010-0011-x. 3. Chang A, Agredano Y, Kimball A. Risk factors associated with striae gravidarum. J Am Acad Dermatol. 2004;51(6):881-885. doi:10.1016/j.jaad.2004.05.030. 4. Lee KS et al. Clin Exp Dermatol 1994; of their existing 19(4):285–288. 4. LEE K, RHO Y, JANG S, SUH M, SONG J. Decreased expression of collagen and fibronectin genes in striae distensae tissue. Clin Exp Dermatol. 1994;19(4):285-288. doi:10.1111/j.1365-2230.1994.tb01196.x. 18.2 % 5. Klehr N. Striae cutis atrophicae. Morphokinetic examinations in vitro. Acta dermato-venereologica. Supplementum. 1979;59(85):105-8. 6. Tsuji T, Sawabe M. Elastic fibers in striae distensae. J Cutan Pathol. 1988;15(4):215- stretch marks 222. doi:10.1111/j.1600-0560.1988.tb00547.x. 7. Osman H, Usta IM, Rubeiz N, Abu-Rustum R, Charara I, Nassar AH. Cocoa butter lotion for prevention of Striae Gravidarum: a double-blind, randomised and placebo-controlled trial. BJOG 2008; 115: 1138-1142 8. Bernstein E. What Causes Stretch Marks? December 2008. The Patient’s Guide to Stretch Marks. 9. Al-Himdani S, Ud-Din S, Gilmore S, Bayat A. Striae distensae: a comprehensive review and evidence-based evaluation of prophylaxis and treatment. British Journal of Dermatology. 2014;170(3):527-547. doi:10.1111/bjd.12681. 10. Malkova S. The Effect of Innovative Gel in the Prevention and Treatment of Striae Control group Stratamark as only using Stratamark (Stratamark Gel). NEUMM. 2014;1–4/4: 1-7. 11. CD Hughes, A Hedges, The use of an innovative film-forming gel in preventing Striae Gravidarum and treating Striae Distensae, Australasian Journal of Dermatology, 2018. Caution: For external use only. Always read the label. Use only as directed. Keep out of reach of children. For further instructions please refer to the Patient Information Leaflet (PIL). monotherapy (=monotherapy) Class I Medical Device, Manufactured by: Stratpharma AG, FDA Listed/TGA Registered Aeschenvorstadt 57, CH-4051 Basel, Switzerland SK-ML-020-3-0119 Striae Distensae are a form of pathological scarring Striae are a pathological condition of the Distribution of gestational ages when Striae connective tissue.1 The pathogeneses are first appear changes in the extracellular matrix, especially in collagen, elastin and fibrillin.2–5 Histologically, Striae are atrophic scars. The Symptomatic relief Film-forming, flexible, collagen ruptures and the gap is filled with full contact Mode of action newly synthesized collagen, which aligns in Stratamark relieves the accordance with the local stress forces.6 itching and discomfort of Stratamark is a flexible, stretch marks. full-contact dressing that Although Striae are not detrimental to health, forms a thin film and they can cause physical symptoms such as ensures constant contact Hydration Modulation itchiness, tenderness and pain.7 Because of with the skin. Stratamark is semi-occlusive and gas perme- Stratamark influences the epidermal-dermal their visibility, they can also significantly affect able, which allows the skin to breathe and signaling cascade via a regulation role of the a woman’s self-esteem and image.7 remain hydrated. epidermis on fibroblast production. Keratino- cytes have shown to activate the fibroblasts, hence collagen and glycosaminoglycan Reduces redness and production. This leads to the normalizing of discoloration Protection the keratinocyte hydration status and the Hormonal changes are one of the main risk factors for the development of stetch marks.8 Stratamark reduces normalizing of tissue growth factors, which Non-reactive Stratamark protects the skin from irritants and redness and discoloration signals dermal fibroblasts to normalize the microbial invasion while reducing the risk for 13 of stretch marks. Stratamark is collagen synthesis cycle of stretch marks. non-reactive. It is contact dermatitis. suitable for pregnant Histological comparison of normal skin, Striae Rubrae women, breastfeeding 9 mothers, children and and Striae Albae people with sensitive skin as it does not contain Prevention of stretch marks during When the use of Stratamark is initiated in the th Normal skin Striae Rubrae Striae Albae alcohol, fragrances or pregnancy: 13 week of pregnancy, approximately 3 50g tubes are required for a full treatment Light adherence parabens. Stratamark is recommended for use from Epidermis including 60–90 days post partum, when used the beginning of the second trimester (13 Papillary Lightly bonds to the most on breast, thighs and abdomen. dermis weeks) or at the first sign of stretch marks. superficial layer of the Treatment should be continued following birth skin. Reticular for a minimum of 60 to 90 days. dermis Treatment of existing stretch marks: Stratamark should be used for at least 60 to 90 Elastin Collagen Medical device days (24 hours a day/ 7 days a week). Contin- Stratamark is a Class I ued use is recommended until no further European, TGA improvement is seen. Severe and/or older Normal skin: randomly Striae Rubrae: fine elastic Striae Albae: histology Softens and flattens (Therapeutic Goods stretch marks may need longer treatment. arranged small collagen and fibres predominate in the demonstrates epidermal Stratamark may also be used in combination Stratamark softens and Administration) registered • One 20g tube contains enough gel for thin elastin fibres in the dermis with thicker fibres in atrophy and loss of the rete with other stretch mark treatments including flattens raised and and FDA listed medical approximately one month of treatment papillary dermis, coarse the periphery; there is a ridges; densely packed, thin laser therapy (non-ablative lasers, PDL, IPL, depressed stretch marks. device. in the late stages of pregnancy. elastic fibres and thick reduction and reorganization eosinophilic collagen bundles Radio Frequency devices). bundles of collagen parallel of elastin and fibrillin fibres are arranged horizontally, • One 50g tube contains enough gel for to the direction on the skin in and structural changes in parallel to the surface of the approximately two months of treatment the reticular dermis. collagen are seen. skin in a similar way to a in the late stages of pregnancy. scar..
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