LC-MS/MS Method Development for Quantitative Analysis of Cyanogenic
LC-MS/MS METHOD DEVELOPMENT FOR QUANTITATIVE ANALYSIS OF CYANOGENIC GLYCOSIDES IN ELDERBERRY AND LIPID PEROXIDATION PRODUCTS IN MICE _______________________________________ A Dissertation presented to the Faculty of the Graduate School at the University of Missouri-Columbia _______________________________________________________ In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy _____________________________________________________ by MICHAEL KWAME APPENTENG Dr. C. Michael Greenlief, Dissertation Supervisor May 2021 © Copyright by Michael Kwame Appenteng 2021 All Rights Reserved The undersigned, appointed by the dean of the Graduate School at the University of Missouri-Columbia, have examined the dissertation entitled. LC-MS/MS Method Development for Quantitative Analysis of Cyanogenic Glycosides in Elderberry and Lipid Peroxidation Products in Mice presented by Michael Kwame Appenteng, a candidate for the degree of Doctor of Philosophy in Chemistry, and hereby certify that, in their opinion, it is worthy of acceptance. Professor C. Michael Greenlief Professor Silvia S. Jurisson Professor John D. Brockman Professor Chung-Ho Lin DEDICATION This dissertation is dedicated to my dear wife, Naa Adjorkor Sowah and delightful son, Frank Cudjoe Appenteng, for their love, unwavering support, and inspiration. Also, to my selfless parents, Frank Cudjoe and Comfort Asaku, who in little, never compromised on quality education. ACKNOWLEDGMENTS I have received a great deal of support and assistance throughout my research, dissertation writing and entire graduate school experience. I would first like to express my deepest appreciation to my advisor, Dr. C. Michael Greenlief for his unparalleled mentorship, patient and invaluable scientific insights and contributions to my work. Being part of the Greenlief research group has exposed me to great research projects, which have shaped me into an effective and efficient researcher.
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