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COMBINED LIST of Particularly Hazardous Substances
COMBINED LIST of Particularly Hazardous Substances revised 2/4/2021 IARC list 1 are Carcinogenic to humans list compiled by Hector Acuna, UCSB IARC list Group 2A Probably carcinogenic to humans IARC list Group 2B Possibly carcinogenic to humans If any of the chemicals listed below are used in your research then complete a Standard Operating Procedure (SOP) for the product as described in the Chemical Hygiene Plan. Prop 65 known to cause cancer or reproductive toxicity Material(s) not on the list does not preclude one from completing an SOP. Other extremely toxic chemicals KNOWN Carcinogens from National Toxicology Program (NTP) or other high hazards will require the development of an SOP. Red= added in 2020 or status change Reasonably Anticipated NTP EPA Haz list COMBINED LIST of Particularly Hazardous Substances CAS Source from where the material is listed. 6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10- hexachloro-1,5,5a,6,9,9a-hexahydro-, 3-oxide Acutely Toxic Methanimidamide, N,N-dimethyl-N'-[2-methyl-4-[[(methylamino)carbonyl]oxy]phenyl]- Acutely Toxic 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (Methyl-CCNU) Prop 65 KNOWN Carcinogens NTP 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) IARC list Group 2A Reasonably Anticipated NTP 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) Prop 65 1-(o-Chlorophenyl)thiourea Acutely Toxic 1,1,1,2-Tetrachloroethane IARC list Group 2B 1,1,2,2-Tetrachloroethane Prop 65 IARC list Group 2B 1,1-Dichloro-2,2-bis(p -chloropheny)ethylene (DDE) Prop 65 1,1-Dichloroethane -
Secondary Organic Aerosol from Chlorine-Initiated Oxidation of Isoprene Dongyu S
Secondary organic aerosol from chlorine-initiated oxidation of isoprene Dongyu S. Wang and Lea Hildebrandt Ruiz McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78756, USA 5 Correspondence to: Lea Hildebrandt Ruiz ([email protected]) Abstract. Recent studies have found concentrations of reactive chlorine species to be higher than expected, suggesting that atmospheric chlorine chemistry is more extensive than previously thought. Chlorine radicals can interact with HOx radicals and nitrogen oxides (NOx) to alter the oxidative capacity of the atmosphere. They are known to rapidly oxidize a wide range of volatile organic compounds (VOC) found in the atmosphere, yet little is known about secondary organic aerosol (SOA) 10 formation from chlorine-initiated photo-oxidation and its atmospheric implications. Environmental chamber experiments were carried out under low-NOx conditions with isoprene and chlorine as primary VOC and oxidant sources. Upon complete isoprene consumption, observed SOA yields ranged from 8 to 36 %, decreasing with extended photo-oxidation and SOA aging. Formation of particulate organochloride was observed. A High-Resolution Time-of-Flight Chemical Ionization Mass Spectrometer was used to determine the molecular composition of gas-phase species using iodide-water and hydronium-water 15 cluster ionization. Multi-generational chemistry was observed, including ions consistent with hydroperoxides, chloroalkyl hydroperoxides, isoprene-derived epoxydiol (IEPOX) and hypochlorous acid (HOCl), evident of secondary OH production and resulting chemistry from Cl-initiated reactions. This is the first reported study of SOA formation from chlorine-initiated oxidation of isoprene. Results suggest that tropospheric chlorine chemistry could contribute significantly to organic aerosol loading. -
Health Effects Support Document for Hexachlorobutadiene Health Effects Support Document for Hexachlorobutadiene
Health Effects Support Document for Hexachlorobutadiene Health Effects Support Document for Hexachlorobutadiene U.S. Environmental Protection Agency Office of Water (4304T) Health and Ecological Criteria Division Washington, DC 20460 www.epa.gov/safewater/ EPA 822-R-03-002 February 2003 Printed on Recycled Paper FOREWORD The Safe Drinking Water Act (SDWA), as amended in 1996, requires the Administrator of the Environmental Protection Agency (EPA) to establish a list of contaminants to aid the agency in regulatory priority setting for the drinking water program. In addition, SDWA requires EPA to make regulatory determinations for no fewer than five contaminants by August 2001. The criteria used to determine whether or not to regulate a chemical on the CCL are the following: The contaminant may have an adverse effect on the health of persons. The contaminant is known to occur or there is a substantial likelihood that the contaminant will occur in public water systems with a frequency and at levels of public health concern. In the sole judgment of the administrator, regulation of such contaminant presents a meaningful opportunity for health risk reduction for persons served by public water systems. The Agency’s findings for the three criteria are used in making a determination to regulate a contaminant. The Agency may determine that there is no need for regulation when a contaminant fails to meet one of the criteria. This document provides the health effects basis for the regulatory determination for hexachlorobutadiene. In arriving at the regulatory determination, data on toxicokinetics, human exposure, acute and chronic toxicity to animals and humans, epidemiology, and mechanisms of toxicity were evaluated. -
Detection of Estrogen Receptor Endocrine Disruptor Potency of Commonly Used Organochlorine Pesticides Using the LUMI-CELL ER Bioassay
DEVELOPMENTAL AND REPRODUCTIVE TOXICITY Detection of Estrogen Receptor Endocrine Disruptor Potency of Commonly Used Organochlorine Pesticides Using The LUMI-CELL ER Bioassay John D. Gordon1, Andrew C: Chu1, Michael D. Chu2, Michael S. Denison3, George C. Clark1 1Xenobiotic Detection Systems, Inc., 1601 E. Geer St., Suite S, Durham, NC 27704, USA 2Alta Analytical Perspectives, 2714 Exchange Drive, Wilmington, NC 28405, USA 3Dept. of Environmental Toxicology, Meyer Hall, Univ. of California, Davis; Davis, CA 95616 USA Introduction Organochlorine pesticides are found in many ecosystems worldwide as result of agricultural and industrial activities and exist as complex mixtures. The use of these organochlorine pesticides has resulted in the contamination of lakes and streams, and eventually the animal and human food chain. Many of these pesticides, such as pp ’-DDT, pp ’-DDE, Kepone, Vinclozolin, and Methoxychlor (a substitute for the banned DDT), have been described as putative estrogenic endocrine disruptors, and act by mimicking endogenous estrogen 1-3 . Estrogenic compounds can have a significant detrimental effect on the endocrine and reproductive systems of both human and other animal populations 4 . Previous studies have shown a strong association between several EDCs (17p-Estradiol, DES, Zeralanol, Zeralenone, Coumestrol, Genistein, Biochanin A, Diadzein, Naringenin, Tamoxifin) and estrogenic activity via uterotropic assay, cell height, gland number, increased lactoferrin, and a transcriptional activity assay using BG1Luc4E2 cells4 . Some other examples of the effects of these EDCs are: decreased reproductive success and feminization of males in several wildlife species; increased hypospadias along with reductions in sperm counts in men; increase in the incidence of human breast and prostate cancers; and endometriosis 3-5 . -
Removal of AOX in Activated Sludge of Industrial Chemical Dyestuff with Bimetallic Pd/Fe Particles
water Article Removal of AOX in Activated Sludge of Industrial Chemical Dyestuff with Bimetallic Pd/Fe Particles Cancan Xu 1, Rui Liu 1, Wei Zheng 1,*, Lichu Lin 1 and Lvjun Chen 1,2 1 Zhejiang Provincial Key Laboratory of Water Science and Technology, Department of Environment in Yangtze Delta Region Institute of Tsinghua University, Jiaxing 314006, China; [email protected] (C.X.); [email protected] (R.L.); sifl[email protected] (L.L.); [email protected] (L.C.) 2 School of Environment, Tsinghua University, Beijing 100084, China * Correspondence: [email protected]; Tel.: +86-0573-8258-1603 Abstract: Pd/Fe bimetallic particles were synthesized by chemical deposition and used to remove absorbable organic halogens (AOX) in the activated sludge of a chemical dyestuff wastewater treatment plant. Bath experiments demonstrated that the Pd/Fe bimetallic particles could effectively remove AOX. It indicated several factors, such as Pd loading, the amount of Pd/Fe used, initial activated sludge pH, and reaction time, which could affect the removal effect. The results showed that increasing the Pd content in Pd/Fe particles, from 0.01 to 0.05 wt %, significantly increased the removal efficiency of AOX in activated sludge. The Pd/Fe particles had a much higher removal efficiency of AOX in the activated sludge than bare Fe particles. A slightly acidic condition with a Pd content of 0.05% and 10 g/L of Pd/Fe was beneficial to the process of removing AOX in activated sludge. In detail, the removal efficiency of AOX in the activated sludge could reach 50.7% after 15 days of reaction with 10 g/L of Pd/Fe (Pd loading 0.05 wt %) and at an initial pH of 6.0 during the experiments. -
WO 2012/148799 Al 1 November 2012 (01.11.2012) P O P C T
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2012/148799 Al 1 November 2012 (01.11.2012) P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 9/107 (2006.01) A61K 9/00 (2006.01) kind of national protection available): AE, AG, AL, AM, A 61 47/10 (2006.0V) AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, (21) International Application Number: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, PCT/US2012/034361 HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, (22) International Filing Date: KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, 20 April 2012 (20.04.2012) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, (25) Filing Language: English SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (26) Publication Language: English TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 61/480,259 28 April 201 1 (28.04.201 1) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, (71) Applicant (for all designated States except US): BOARD UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, OF REGENTS, THE UNIVERSITY OF TEXAS SYS¬ TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, TEM [US/US]; 201 West 7th St., Austin, TX 78701 (US). -
The Effect of Individual and Mixtures of Mycotoxins and Persistent
Food and Chemical Toxicology 130 (2019) 68–78 Contents lists available at ScienceDirect Food and Chemical Toxicology journal homepage: www.elsevier.com/locate/foodchemtox The effect of individual and mixtures of mycotoxins and persistent organochloride pesticides on oestrogen receptor transcriptional activation T using in vitro reporter gene assays ∗ Ukpai A. Ezea,b,1, John Huntrissc, Michael N. Routledged, Yun Yun Gonga,e, , Lisa Connollyf a School of Food Science and Nutrition, Food Science Building, University of Leeds, LS2 9JT, UK b Department of Medical Laboratory Sciences, Faculty of Health Sciences, Ebonyi State University, P. M. B. 053, Abakaliki, Nigeria c Division of Reproduction and Early Development, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, LS2 9JT, UK d Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, LS2 9JT, UK e Department of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Ministry of Health, Beijing, 100021, PR China f Institute for Global Food Security, School of Biological Sciences, Queens University Belfast, Northern Ireland, BT9 5AF, UK ARTICLE INFO ABSTRACT Keywords: The mycotoxins zearalenone (ZEN) and alpha-zearalenone (α-ZOL), which are common contaminants of agri- Mycotoxins food products, are known for their oestrogenic potential. In addition to mycotoxins, food may also contain Chemical mixtures pesticides with oestrogenic properties such as 1,1,1-trichloro-2,2-bis(p-chlorophenyl) ethane (p,p'-DDT) and 1,1- Food-borne chemical contaminants dichloro-2,2-bis(p-chlorophenyl) ethylene (p,p'-DDE), raising the question on the potential effects of individual Reporter gene assay and combinations of these xeno-oestrogens on the action of natural oestrogens. -
Safe Thermal Decomposition of Organochloride Pesticides by Submerged Oxidation in Molten Salts LAINETTI, P
Safe Thermal Decomposition of Organochloride Pesticides by Submerged Oxidation in Molten Salts LAINETTI, P. E. O. A a. Instituto de Pesquisas Energéticas e Nucleares IPEN-CNEN/SP, São Paulo * Corresponding author: [email protected] Abstract This study was motivated by the current interest in the world in the development of advanced processes for waste decomposition, category in which the process described herein is inserted. This interest stems from the need for safer processes for the decomposition of some wastes, particularly those deemed hazardous or present significant impact on the environment. The technology developed fits into this principle and it is applicable for intrinsically safe disposal of hazardous organic wastes, particularly the organochloride, whose degradation has presented problems when using the most common methods, such as incineration. Pesticides banned, obsolete or discarded constitute a serious environmental risk around the world, especially in developing countries. The HCHS, or Hexachlorcyclohexanes also called BHC or Lindane, are organochloride insecticides that have been banned in most countries in the 70s and 80s. It is one of the compounds that constitute the group of so-called POPs, or persistent organic pollutants that are regulated internationally by the Basel Convention. Among the major POPs could be cited pesticides, dioxins and PCBs that represent, according to the United Nations Industrial Development Organization - UNIDO, one of the most serious and urgent problems to be faced, because on the one hand, -
Prenatal Testosterone Supplementation Alters Puberty Onset, Aggressive Behavior, and Partner Preference in Adult Male Rats
J Physiol Sci (2012) 62:123–131 DOI 10.1007/s12576-011-0190-7 ORIGINAL PAPER Prenatal testosterone supplementation alters puberty onset, aggressive behavior, and partner preference in adult male rats Cynthia Dela Cruz • Oduvaldo C. M. Pereira Received: 26 October 2011 / Accepted: 19 December 2011 / Published online: 11 January 2012 Ó The Physiological Society of Japan and Springer 2012 Abstract The objective of this study was to investigate because pregnant women exposed to hyperandrogenemia whether prenatal exposure to testosterone (T) could change and then potentially exposing their unborn children to ele- the body weight (BW), anogenital distance (AGD), ano- vated androgen levels in the uterus can undergo alteration of genital distance index (AGDI), puberty onset, social normal levels of T during the sexual differentiation period, behavior, fertility, sexual behavior, sexual preference, and T and, as a consequence, affect the reproductive and behavior level of male rats in adulthood. To test this hypothesis, patterns of their children in adulthood. pregnant rats received either 1 mg/animal of T propionate diluted in 0.1 ml peanut oil or 0.1 ml peanut oil, as control, Keywords Aggressive behavior Á Male rats Á on the 17th, 18th and 19th gestational days. No alterations in Prenatal testosterone Á Puberty onset Á Sexual behavior Á BW, AGD, AGDI, fertility, and sexual behavior were Sexual differentiation observed (p [ 0.05). Delayed onset of puberty (p \ 0.0001), increased aggressive behavior (p [ 0.05), altered pattern of sexual preference (p \ 0.05), and reduced T plasma level Introduction (p \ 0.05) were observed for adult male rats exposed pre- natally to T. -
Organochloride Pesticides Present in Animal Fur, Soil, and Streambed in an Agricultural Region of Southeastern Arkansas Matthew E
Journal of the Arkansas Academy of Science Volume 72 Article 19 2018 Organochloride Pesticides Present in Animal Fur, Soil, and Streambed in an Agricultural Region of Southeastern Arkansas Matthew E. Grilliot Auburn University--Montgomery, [email protected] John L. Hunt University of Arkansas at Monticello, [email protected] Christopher G. Sims University of Arkansas at Monticello, [email protected] Follow this and additional works at: https://scholarworks.uark.edu/jaas Part of the Environmental Health Commons, and the Zoology Commons Recommended Citation Grilliot, Matthew E.; Hunt, John L.; and Sims, Christopher G. (2018) "Organochloride Pesticides Present in Animal Fur, Soil, and Streambed in an Agricultural Region of Southeastern Arkansas," Journal of the Arkansas Academy of Science: Vol. 72 , Article 19. Available at: https://scholarworks.uark.edu/jaas/vol72/iss1/19 This article is available for use under the Creative Commons license: Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0). Users are able to read, download, copy, print, distribute, search, link to the full texts of these articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This Article is brought to you for free and open access by ScholarWorks@UARK. It has been accepted for inclusion in Journal of the Arkansas Academy of Science by an authorized editor of ScholarWorks@UARK. For more information, please contact [email protected], [email protected]. Journal of the Arkansas Academy of Science, Vol. 72 [], Art. 19 Organochloride Pesticides Present in Animal Fur, Soil, and Streambed in an Agricultural Region of Southeastern Arkansas M.E. -
Prohibited Chemicals
PROHIBITED CHEMICALS CHEMICAL TRADE NAME NOTES Atrazine Atrazine Toxicity group III Gesaprim Atraflo Bladex Terbutal Parathion Folidol An organophosphate. Extremely toxic, Toxic group I. Banned in 17 Diethyl (p –nitropheny) phosphothioate Parafos countries, restricted use status in RSA. Agrithion PCP Woodprufe An organochloride Pentachlorophenol Timerlife Pentachlorophenyl Borcide Timbertret Anti-stain Chlordane Termidan An organochlorine insecticide. Moderately, toxic, toxic group I Octahoro-a hexahydror-methiodene Chlorsdasol Banned in 25 countries, restricted status in RSA Aldicard Termik A N-Methyl Carbonate insecticide. Extremely toxic, Toxic group I Methyl-(methylthio)-propinaldehyne Methylcarbonmoy oxine EDB Edabrom A halocarbon pesticide. Toxic group II. Dibromoethane Gerbex Banned in 14 countries. Restricted status in RSA. Aquamix Bacfume Dieldrin Aldrin An organochlorine insecticide. Highly toxic, Toxic group I. Hexachloro-hexahydro-dimethanonaphthalene HHDN Banned in 34 countries. Restricted status in RSA. Plus derivities Aldrin and Endrin Shelldrite DDT Dichloro-diphenyl trichloro-ethane plus derivities DDE and DDD Difethialone Rattex Brodifacoum Finale Difenacoum Tornadel Flocoumafen Tornadel Chlorofluoro-carbon Total phase-out by 1996. Manreal protocol 1987, amended CFC-11 , CFC-12 , CFC-113 , CFC-114 , CFC- Copenhagen 1992. 115 Halon gas Total phase-out by 1996. Manreal protocol 1987, amended Halon -1211 , Halon1301 , Halon -2402 Copenhagen 1992. Carbon – tetrachloride CC14 Total phase-out by 1996. Manreal protocol 1987, -
California Proposition 65 (Prop65)
20 NOVEMBER 2018 To Whom It May Concern: Certificate of Compliance California Proposition 65 California’s Proposition 65 entitles California consumers to special warnings for products that contain chemicals known to the state of California to cause cancer and birth defects or other reproductive harm if those products expose consumers to such chemicals above certain threshold levels. This is to certify that Alliance Memory comply with Safe Drinking Water and Toxic Enforcement Act of 1986, commonly known as California Proposition 65, that are ‘known to the state to cause cancer or reproductive toxicity’ as of December 29, 2017, by following the labelling guidelines set out therein. Alliance Memory labelling system clearly states a ‘Prop65 warning’ as and when necessary, on product packaging that is destined for the state of California, USA. This document certifies that to the best of our current knowledge and belief and under normal usage, Alliance Memory’s IC products are in compliance with California Proposition 65 – The Safe Drinking Water and Toxic Enforcement Act, 1986) and do not contain chemical elements of those listed within the California Proposition 65 chemical listing as shown below. Signature : Date: 20 November 2018 Name : Kim Bagby Title : Director QRA Department/Alliance Memory California Proposition 65 list of chemicals. The following is a list of chemicals published as a requirement of Safe Drinking Water and Toxic Enforcement Act of 1986, commonly known as California Proposition 65, that are ‘known to the state to cause