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Guidelines for Red Blood Cell and Plasma Transfusion for Adults and Children Special Supplement Expert Working Group* Supplément Spécial

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Guidelines for Red Blood Cell and Plasma Transfusion for Adults and Children Special Supplement Expert Working Group* Supplément Spécial Guidelines for red blood cell and plasma transfusion for adults and children Special Supplement Expert Working Group* Supplément spécial Abstract *Members of the Expert Working Group are: Edward Crosby, MD, FRCPC (chair), Objective: To provide broad guidelines and principles to help physicians, other health Ottawa General Hospital, care workers and patients make decisions about the appropriateness of red blood Ottawa, Ont.; David Ferguson, cell and plasma transfusion. MD, FRCPC, Royal Columbian Options: These guidelines are limited to red blood cell and plasma transfusion in adults Hospital, New Westminister, and children over 4 months of age. Indications for specific clinical conditions and BC; Heather Ann Hume, MD, specialized blood components are not addressed. Options considered included ap- FRCPC, Hôpital Sainte-Justine, propriate use of allogeneic and autologous transfusion and substituting non-blood Montréal, Qué.; Jonathan B. alternatives. Kronick, MD, PhD, FRCPC, Outcomes: Patient well-being, avoidance of risk and appropriate use of the allogeneic Children’s Hospital of Western blood supply. Ontario, London Health Evidence: Existing practice guidelines and published research supporting clinical indi- Sciences Centre, London, Ont.; cations for transfusions; a review of the legal and ethical issues pertaining to transfu- Bryce Larke, MD, CM, DclSc, sion practices; physician focus groups to assess current needs in the field of transfu- Canadian Red Cross Society sion and counseling practices. Blood Transfusion Service, Values: Provision of optimum patient care and prudent clinical use of a precious re- Edmonton, Alta.; Pierre source, the allogeneic blood supply. Patients should be involved in transfusion deci- LeBlond, MD, CSPQ, Hôpital du sions whenever possible. Saint-Sacrement, Québec, Que.; Benefits, harms, costs: The risks and benefits of using allogeneic and autologous blood Barry McLellan, MD, FRCPC, for transfusion were weighed and compared with those associated with non-blood al- Sunnybrook Health Science Centre, Toronto, Ont.; ternatives. Costs, both monetary and non-monetary, were considered when known. Theodore E. Warkentin, MD, Recommendations: The recommendations relate to the dissemination of blood product FRCPC, FACP, Hamilton information, the participatory process of informed consent and the clinical indications Health Sciences Corporation, for blood product transfusion. Each recommendation was rated based on the strength Hamilton General Campus, of the supporting evidence. In brief, patients should be informed about transfusion. Ac- Hamilton, Ont. curate data regarding the risks of transfusion should be available to and used by physi- cians to inform patients effectively. Red blood cell transfusion, allogeneic or autolo- gous, should be given to increase oxygen carriage in the blood in situations where this Consultants included: Tina is likely to be inadequate. Plasma should be given primarily to support coagulation in Beranbaum, PhD, Beranbaum & the setting of multiple factor deficiencies or for therapeutic plasmapheresis for specific Associates, Ottawa, Ont.; Lisa indications. Transfusion committees should function at a local level to assist in the dis- Calder, BScH, Ottawa, Ont.; semination of information and establishment of prudent transfusion practices. Tony Giulivi, MD, FRCPC, Endorsement: The guidelines are endorsed by the following national associations: Aplas- Associate National Director of tic Anemia Association of Canada, Canadian Anesthetists’ Society, Canadian Associa- Medical and Scientific Affairs, tion of Emergency Physicians, Canadian Association of General Surgeons, Canadian National Office of the Canadian Association of Pathologists, Canadian Blood Agency, Canadian Cardiovascular Soci- Red Cross Society, Ottawa, Ont; ety, Canadian Critical Care Society, Canadian Healthcare Association, Canadian He- Brian Grainger, MA, Grainger mophilia Society, Canadian Infectious Disease Society, Canadian Nurses Association, and Associates, Ottawa, Ont.; Canadian Orthopaedic Association, Canadian Paediatric Society, Canadian Red Paul Hébert, MD, FRCPC, Cross Society, Canadian Society for Transfusion Medicine, Canadian Society of Inter- Ottawa General Hospital, nal Medicine, Canadian Society of Laboratory Technologists, Canadian Transplanta- Ottawa, Ont.; Ellen Margolese, tion Society, College of Family Physicians of Canada, Patient Alumni Board of the Ot- LLB, Ottawa, Ont.; Colette tawa Heart Institute, Society of Obstetricians and Gynaecologists of Canada and Rivet, MLT, ART, CLS, CHE, Trauma Association of Canada. Director of Scientific Resources, Sponsors: Funding was provided by the Canadian Blood Agency, the Canadian Red Canadian Blood Agency, Ottawa, Cross Society and Health Canada. The Canadian Medical Association managed the Ont. overall project and convened the group of experts who developed the guidelines. The guidelines reflect the views of the scientific experts and should not be seen as This article has been peer an endorsement of the CMA. reviewed. CAN MED ASSOC J • JUNE 1, 1997; 156 (11 suppl) S1 © 1997 Canadian Medical Association (text and abstract) Expert Working Group deally, practice guidelines are intended to assist ments for full disclosure irrespective of the clinical sce- practitioners and patients to make decisions about nario with a more pragmatic approach that considers I appropriate health care.1 They are not intended to disclosing transfusion-related information in light of the provide a rigid prescription for care. Guidelines should patient’s clinical situation. be discussed, adopted or modified according to local The EWG believes that the risk associated with red clinical needs and constraints. blood cell and plasma transfusion must be placed in the context of the overall risk associated with an illness or Why do we need Canadian guidelines for procedure. Blood transfusion is often given in situations, red blood cell and plasma transfusion? such as surgery, chemotherapy or critical illness, where the risk from transfusion is small compared with the Many available guidelines are outdated, because the overall risks. Undue emphasis on the risks from blood science and the blood system have changed dramatically transfusion was thought by some to be both unreason- in the last decade. Some guidelines reflect values that are able and imprudent, as it could confuse patients about not relevant to Canada; others rely heavily on “expert” the absolute and relative risks they are facing. For exam- opinions rather than critical review of evidence. Al- ple, coronary artery bypass grafting has an approximate though in some areas of transfusion inadequate scientific composite risk of stroke, myocardial infarction and evidence exists and “expert” opinions are necessary, in death of 1% to 2%. Is it then necessary or even appro- other areas sufficient evidence exists and should be used priate to do more than advise patients that they have a to generate recommendations. As well, some guidelines 10% to 40% probability of receiving a blood transfu- deal only with surgical populations; for other popula- sion, with which there are associated remote but real tions, patients with chronic anemia and, particularly, risks, then solicit the patient’s response and questions. children, guidelines do not exist. The EWG agreed that, where clinically appropriate, The great many publications on transfusion medicine patients should be advised that alternatives to allogeneic in the last decade require synthesis and interpretation. transfusion exist, but members could not reach consensus New blood programs, such as autologous predeposit and on the need to discuss them in detail, given their inconsis- intraoperative cell salvage, lack criteria for best integrat- tent availability and varying effectiveness in averting allo- ing them into the predominantly allogeneic system. Crit- geneic exposure and preventing transmissible diseases. ical evaluation of current transfusion practices in Canada Finally, the EWG agreed that patients should be in- may lead to new perspectives in clinical decision-making formed that they have received red blood cells or plasma as and applying new information and new choices. soon as possible following transfusion, but could not reach Those generating guidelines have certain values that consensus on who should inform them (e.g., treating influence how the evidence is reviewed and the guide- physician, prescribing physician, blood bank, hospital ad- lines are elaborated. Two principles guided the Expert ministration) or how to ensure that they were informed. Working Group (EWG): the guidelines should permit optimal patient care while fostering prudent clinical use Transfusion threshold of the precious allogeneic blood supply. The EWG con- sidered avoidance of transfusion to be ideal to the extent These guidelines differ from others in not explicitly that avoidance was not likely to be a more serious risk recommending a threshold hemoglobin concentration than the transfusion. In addition, the members believe or range of concentrations at which patients should be that, whenever possible, patients should be involved in transfused. EWG members agreed that there was no ev- transfusion decisions. idence to support the generation of such thresholds. The EWG believes that the decision to transfuse should Informed consent and information be made after review of the patient and the clinical situa- disclosure tion; in addition, timely measurement of hemoglobin concentrations should be considered.
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