ENCALS statement on edaravone, Conflict of Interest (COI) - July 2017

Name Affiliation COI Philip Van Damme KU – University of received consulting fees from Leuven, Department of Neurosciences, Mitsubishi, Cytokinetics, Biogen Idec Experimental Neurology; VIB Center for Brain & Disease Research; University Hospitals Leuven, Department of Neurology, Leuven, Belgium

Denmark Kirsten Svenstrup Department of Neurology, Bispebjerg no disclosures Hospital, Copenhagen, Denmark

Merete Karlsborg Department of Neurology, Bispebjerg no disclosures Hospital, Copenhagen, Denmark

Finland Hannu Laaksovirta Helsinki University Central Hospital, No disclosures Finland

France Francois Salachas Hôpital de la Salpêtrière, Paris, France no disclosures

Philippe Corcia Centre de compétence SLA-fédération Invesigator for clinical trials led by Tours-Limoges, CHU de Tours, France Cytokinetics, Consulting fees from Roche Philippe Couratier Centre de compétence SLA-fédération no disclosures Tours-Limoges, CHU de Limoges, Fance Claude Desnuelle Hôpital Pasteur 2 – CHU de Nice, consultant EFFIK SA France, Sanofi France –Genzyme Co, NanoMedSyn

Germany Julian Grosskreutz Hans-Berger Department of Neurology, consulted for Biogen Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany Thomas Meyer ALS Outpatient Department, Charité - consulted for Cytokinetics, GSK and Universitätsmedizin Berlin, Germany Desitin Arzneimittel GmbH, founder of the internet platform Ambulanzpartner and co-owner of Ambulanzpartner Soziotechnologie GmbH Susanne Petri Department of Neurology, Hannover consulted for Cytokinetics, Medical School, Hannover, Germany Investigator for clinical trials led by Cytokinetics, Orion Pharma, Biogen Idec, GlaxoSmithKline; speaking honoraria from Teva Jan Christoph Koch Department of Neurology, University Co-PI of IIT ROCK-ALS Medicine Göttingen, Göttingen, Germany

Patrick Weydt Department of Neurodegenerative no disclosures Diseases and Gerontopsychiatry, Bonn University, Germany Joachim Wolf Department of Neurology, Mannheim, no disclosures Diakonissenkrankenhaus, Germany

Torsten Grehl Alfried Krupp Krankenhaus, no disclosures Rüttenscheid, Germany Albert Ludolph Department of Neurology, University of on an advisory board of Biogen, Ulm, Germany Treeway, Hoffmann-La Roche, has signed contracts for clinical Studies with AB Science, Biogen Idec, Cytokinetics, GSK, Orion Pharam, Novartis, TauRx Therapeutics Ltd. and TEVA Pharmaceuticals, consulted for Mitsubishi, Orion Pharma, Novartis, Teva

Ireland Orla Hardiman Academic Unit of Neurology, Trinity consulted for Mitsubishi and for Biomedical Sciences Institute, Trinity Treeway College, Dublin, Ireland

Italy Adriano Chio Rita Levi Montalcini' Department of served on an advisory panel on Neuroscience, ALS Center, University of MITOS and KING'S for Mitsubishi- Torino, Torino, Italy Tanabe, consultant without compensato to Treeway, consultant for Biogen Idec and Italfarmaco

Vincenzo Silani Department of Neurology-Stroke Unit received consulting fees from and Laboratory of Neuroscience, Mitsubishi and Cytokinetics Department of Pathophysiology and Transplantation, Center for Neurotechnology and Brain Therapeutics, Università degli Studi di Milano, IRCCS Istituto Auxologico Italiano, Piazzale Brescia no. 20, 20149 Milan, Italy Netherlands Leonard H van den Department of Neurology, Brain Center consultant without compensation to Berg Rudolf Magnus, University Medical Treeway, LHvdb declares personal Center Utrecht, Utrecht, The fees from Baxalta, and is a member Netherlands of the Scientific Advisory Boards for Biogen Idec, Cytokinetics and Orion

Anneke van der Kooi Department of Neurology, Academic received research grant from Behring Medical Centre, for investigator initiated study Center, The Netherlands.

Norway Trygve Holmøy Kershus Universitetssykehus Rec eived consulting fees from Lørenskog, Norway Biogen, Merck, Genzyme and run studies without compensation for Merck and Biogen, not related to ALS

Grethe Kleveland Avdeling for nevrologi og klinisk no disclosures nevrofysiologi, Sykehuset Innlandet, Lillehammer, Norway Ole-Bjørn Tysnes Haukeland universitetssjukehus, Bergen no disclosures

Poland Magdalena Kuzma- Department of Neurology​, Medical no disclosures Kozakiewicz University of Warsaw, Żwirki i Wigury 61, 02-091, Poland

Portugal Mamede de Carvalho Institute of Physiology-Instituto de Received consulting fees from Medicina Molecular, Faculty of Medicine, Biogen, Merck Idec, Kedrion and University of Lisbon, Portugal. Cytokinetics Department of Neurosciences And Mental Health, H Santa Maria-CHLN, Portugal

Scotland Siddharthan , Scotland, UK no disclosures Chandran

Slovenia Blaz Koritnik Institute of Clinical Neurophysiology, no disclosures University Medical Centre Ljubljana, Zaloska 7, SI-1000 Ljubljana, Slovenia

Spain Jesus Mora Pardina Madrid, Spain consulted for AB-Science Mónica Povedano Neurology department Hospital no disclosures Panades Universitario de Bellvitge-IDIBELL, Barcelona, Spain

Sweden Peter M. Andersen Department of Pharmacology and received consulting fees from Biogen Clinical Neuroscience, Umeå University, Idec and Orphazyme ApS on matters SE-901 85 Umeå, Sweden concerning clinical trials and ALS

Bernardo Mitre Sahlgrenska Universitetssjukhuset, no disclosures Ropero Gothenburg, Sweden Ingela Nygren , Sweden no disclosures Gert Staaf , Sweden no disclosures Caroline Ingre Karolinska Instituted, Stockholm, no disclosures Sweden Olof Danielsson Department of Neurology, and no disclosures Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden

Switserland Markus Weber Neuromuscular Diseases Center/ALS received consulting fees from Clinic, Kantonsspital St. Gallen, Mitsubishi, Biogen Idec, Merz Parma St.Gallen, Switzerland Schweiz, consultant without compensation to Treeway

United Kingdom Pamela Shaw Sheffield Institute for Translational Consultant without compensation for Neuroscience, , Treeway and is a member of scientific UK advisory boards for Biogen, and Orion. Christopher Sheffield Institute for Translational Consulted for OrionPharma; McDermott Neuroscience, University of Sheffield, Investigator for studies run by Biogen UK Idec, cytokinetics Kevin Talbot Nuffield Department of Clinical no disclosures Neurosciences, , Oxford, UK Ammar Al-Chalabi Maurice Wohl Clinical Neuroscience Consulted for Mitsubishi-Tanabe Institute, Department of Basic and Pharma, Cytokinetics, OrionPharma, Clinical Neuroscience, King’s College Chronos Therapeutics, Treeway, London, London, UK GSK, Lilly, Biogen Idec; Chief Investigator for clinical trials run by Cytokinetics, OrionPharma; speaking honoraria from Cytokinetics Inc and Lilly