Welcome Address Program Program

Dear colleagues, Wednesday, July 17th, 2019 04:00 pm Regulatory T cells in allogeneic SCT Thon-Dittmer-Palais, Haidplatz 8, 93047 Regensburg Matthias Edinger The reprogramming of T cells for tissue-specifi c therapies 09:00 am Welcome address 04:30 pm Identifi cation of a neoantigen targeted by Philipp Beckhove tumor-infi ltrating lymphocytes in a patient with and the development of environment-smart immune cell Her2+ breast cancer 09:00 am - 01:00 pm Morning session: Hannah Reimann therapies against cancer and autoimmune disorders is Gene immunotherapy: clinical experience one of the most promising concepts for the development Chair: Hermann Einsele 04:45 pm Coffee break 05:00 pm - 06:00 pm Evening session: of new treatment strategies in these diseases. 09:00 am Keynote lecture: Next Generation CAR T Cells Synthetic biology approaches During this RCI-conference, we will present and discuss Carl June Chair: Dirk Busch Chair: Katharina Fleischhauer, Michael Schmitt novel synthetic biology approaches and bring together 05:00 pm Keynote lecture: Rewriting the mammalian cell 10:00 am TCR-T Immunotherapy: Building a Toolbox to ‘source code’ leading experts from around the world to discuss and Enhance Safety and Improve Effi cacy Tudor Fulga advance the fi eld of synthetic immune cell therapy. Dolores Schendel 06:00 pm Social program (registration mandatory): 10:30 am From CAR expressing T cells to CAR NK cells Guided city tour The meeting covers the functional re-programming of for cancer retargeting Ulrike Köhl immune cells to shape their function in tissues in health Thursday, July 18th, 2019 11:00 am T cells gene-engineered with MAGE-C2 TCR to and disease, the curative potential of gene-modifi ed treat melanoma and head-and-neck carcinoma Thon-Dittmer-Palais, Haidplatz 8, 93047 Regensburg immune cells and new synthetic approaches to equip Reno Debets 09:00 am - 01:00 pm: 11:15 am Coffee break Novel functional programs/environment adapted immunity immune cells with extended functional capacities. Chair: Andreas Mackensen, Wolfgang Herr Chair: Thomas Blankenstein We are looking forward to welcoming you for two exciting 11:35 am Engineering Specifi city and Function 09:00 am Keynote lecture: Conversion of of T cells effector T cells into regulatory T cells days in the beautiful city of Regensburg! Hans Stauss Shimon Sakaguchi 12:05 pm The next wave of CAR T cells for cancer Chair: Michael von Bergwelt, André Gessner On behalf of the board of directors Marcela Maus 10:00 am Deciphering the Immune Landscape of Human 12:35 pm Synthetic Targeting and Logic-Gated Orthogo- nal Outputs In the Context of CAR T Cell Immu- Cancer Microenvironment notherapy of Cancer Massimiliano Pagani Philipp Beckhove Michael Jensen 10:30 am Ontogeny of dendritic cells and Macrophages: (Director RCI) 01:05 pm Targeting Metastasis in a Cold Tumor with T From Development to Functions Cell Receptor Based Immunotherapy Florent Ginhoux Stefan Burdach 11:00 am Coffee break 01:20 pm Lunch & poster session Chair: Martin Bornhäuser, Matthias Edinger 02:30 pm - 04:30 pm Afternoon session: 11:30 am Treg cells in non-lymphoid tissues Cell therapy: new concepts Markus Feuerer Chair: Matthias Theobald, Markus Feuerer 12:00 pm Learning cellular differentiation pathways from 02:30 pm Harnessing the miRNA-epigenetic regulatory in vivo lineage tracing of T cells and hemato- circuitry to enhance CD8+ T cell antitumor poietic stem cells immunity Thomas Höfer Luca Gattinoni 12:30 pm Bioinformatics approaches to understand the 03:00 pm CARs, TRUCKs and beyond: the next generation interaction of cancer with the immune system of redirected T cells Benedikt Brors Hinrich Abken 01:00 pm Closing remarks 03:30 pm Engineering regulatory T cell specifi city in Philipp Beckhove autoimmunity and transplantation Megan Levings Farewell & lunch Speakers / Sponsors General Information / Registration SPITZE IN DER MEDIZIN. MENSCHLICH IN DER BEGEGNUNG.

Speakers & Chairs Program Committee Hinrich Abken Hinrich Abken Genetic Immunotherapy Chair for Genetic Immunotherapy RCI Regensburg Center for Interventional Immunology c/o University Hospital Regensburg, Germany RCI Regensburg Center for Interventional Immunology Thomas Blankenstein c/o University Hospital Regensburg, Germany Charité Berlin - Universitätsmedizin Berlin Philipp Beckhove Institut für Immunologie, Berlin Chair for Interventional Immunology Martin Bornhäuser RCI Regensburg Center for Interventional Immunology Universitätsklinikum Carl Gustav Carus, Dresden Benedikt Brors c/o University Hospital Regensburg, Germany Applied Bioinformatics Matthias Edinger Deutsches Krebsforschungszentrum, Heidelberg Department of Internal Medicine III Matthias Edinger University Hospital Regensburg, Germany Department of Internal Medicine III University Hospital Regensburg, Germany Markus Feuerer Hermann Einsele Chair for Immunology Medizin II RCI Regensburg Center for Interventional Immunology Universitätsklinikum Würzburg, Würzburg c/o University Hospital Regensburg, Germany Markus Feuerer Immunology Venue RCI Regensburg Center for Interventional Immunology Thon-Dittmer-Palais, Haidplatz 8, c/o University Hospital Regensburg, Germany 93047 Regensburg, Germany Katharina Fleischhauer Institut für Zelltherapeutische Forschung Sponsors Universitätsklinikum Essen, Essen Becton Dickinson GmbH 1.000 € Tudor Fulga Genome Engineering and Synthetic Biology Celgene GmbH 1.500 € University of Oxford, Oxford CellGenix GmbH 2.000 € Luca Gattinoni ChemoMetec 1.000 € Experimental Transplantation and Immunology Janssen-Cilag GmbH 3.000 € National Cancer Institute, Bethesda Miltenyi Biotec GmbH 2.000 € André Gessner Institut für Mikrobiologie und Hygiene Novartis Pharma GmbH 2.000 € Universitätsklinikum Regensburg, Regensburg TPP Techno Plastic Products 1.000 € Florent Ginhoux Performance for booth fee and advertising purposes. Ontogeny and Differentiation of Macrophages Cells Photographs and fi lm recordings will be made during this event. Singapore Immunology Network (SLgN), Singapore These serve purposes of documentation and will also be used Wolfgang Herr Klinik und Poliklinik für Innere Medizin III for the University Hospital’s publicity work. If you wish to register Universitätsklinikum Regensburg, Regensburg an objection, please contact us on [email protected] by the day Thomas Höfer of the event at the latest. Theoretical Systems Biology (B086) Deutsches Krebsforschungszentrum, Heidelberg Online-Registration Michael Jensen www.congress-registration.ukr.de Ben Towne Center for Childhood Cancer Research Center for Childhood Cancer Research, Seattle Date Carl June July 17th - 18th 2019 Pathology and Laboratory Medicine Perelman School of Medicine at University of Pennsylvania, Philadelphia Conference Fee Ulrike Köhl Industry participants incl. social program & dinner 400 € Institute of Cellular Therapeutics Industry participants excl. social program & dinner 350 € Hannover Medical School, Hannover Megan Levings Regular participation incl. social program & dinner 250 € Faculty of Medicine/Department of Surgery Regular participation excl. social program & dinner 200 € BC Children`s Hospital Research Institute, Vancouver PhD Students incl. social program & dinner 125 € Andreas Mackensen UKR, UR free of charge (conference dinner € 45,-) Regensburg Center for Interventional Immunology RCI Medizinische Klinik 5 - Hämatologie und Internistische Onkologie Registration mandatory prior to the symposium. Universitätsklinikum Erlangen, Erlangen Marcela Maus Participants limited to 150. First come, fi rst serve. Cellular Immunotherapy Organisation MGH Center for Cancer Research, Charlestown Massimiliano Pagani University Hospital Regensburg International RCI symposium Medical Biotechnology and Translational Medicine Conference Division UK3, Britta Haseneder Instituto Nazionale Genetica Moecolare (INGM), Milano Franz-Josef-Strauß-Allee 11 Shimon Sakaguchi 93053 Regensburg, Germany Synthetic Immunology and environ- Experimental Immunology Phone: +49 (0)941 944-4230 | Fax: +49 (0)941 944-4233 WPI Immunology Frontier Research Center, Osaka University, Osaka Dolores Schendel [email protected] ment-adapted redirection of T cells Chief Executive Offi cer and Chief Scientifi c Offi cer Registration conditions Medigene AG, Munich Thon-Dittmer-Palais Regensburg, Germany Michael Schmitt After your successful registration you will receive a payment request concerning your parti- Universitätsklinikum Heidelberg, Heidelberg cipation fee during the next days by email. Once registered your registration is binding. All payments must be made prior to the conference. Participation fees are due upon receipt July 17th - 18th 2019 Hans Stauss of payment request without deduction. Please transfer the participation fee amount before Division of Infection and Immunity the event date. In case of a cancellation the cancellation statement must be in writing. The Institute of Immunity and Transplantation, London following processing fees apply: 8-3 working days before the event 50% of participation fee. Matthias Theobald In case of too late cancellation or absence without written cancellation the entire fee will be Universitätsmedizin Mainz charged. A substitute participant may be submitted at any time. ukr.de III. Medizinischen Klinik,Mainz Michael von Bergwelt MedizinischenKlinik und Poliklinik III Photo and rights: RCI LMU Klinikum der Universität München, München July 2019