DOCSLIB.ORG

Dear Colleagues, the Reprogramming of T Cells for Tissue-Specific

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Dear Colleagues, the Reprogramming of T Cells for Tissue-Specific Welcome Address Program Program Dear colleagues, Wednesday, July 17th, 2019 04:00 pm Regulatory T cells in allogeneic SCT Thon-Dittmer-Palais, Haidplatz 8, 93047 Regensburg Matthias Edinger The reprogramming of T cells for tissue-specifi c therapies 09:00 am Welcome address 04:30 pm Identifi cation of a neoantigen targeted by Philipp Beckhove tumor-infi ltrating lymphocytes in a patient with and the development of environment-smart immune cell Her2+ breast cancer 09:00 am - 01:00 pm Morning session: Hannah Reimann therapies against cancer and autoimmune disorders is Gene immunotherapy: clinical experience one of the most promising concepts for the development Chair: Hermann Einsele 04:45 pm Coffee break 05:00 pm - 06:00 pm Evening session: of new treatment strategies in these diseases. 09:00 am Keynote lecture: Next Generation CAR T Cells Synthetic biology approaches During this RCI-conference, we will present and discuss Carl June Chair: Dirk Busch Chair: Katharina Fleischhauer, Michael Schmitt novel synthetic biology approaches and bring together 05:00 pm Keynote lecture: Rewriting the mammalian cell 10:00 am TCR-T Immunotherapy: Building a Toolbox to ‘source code’ leading experts from around the world to discuss and Enhance Safety and Improve Effi cacy Tudor Fulga advance the fi eld of synthetic immune cell therapy. Dolores Schendel 06:00 pm Social program (registration mandatory): 10:30 am From CAR expressing T cells to CAR NK cells Guided city tour The meeting covers the functional re-programming of for cancer retargeting Ulrike Köhl immune cells to shape their function in tissues in health Thursday, July 18th, 2019 11:00 am T cells gene-engineered with MAGE-C2 TCR to and disease, the curative potential of gene-modifi ed treat melanoma and head-and-neck carcinoma Thon-Dittmer-Palais, Haidplatz 8, 93047 Regensburg immune cells and new synthetic approaches to equip Reno Debets 09:00 am - 01:00 pm: 11:15 am Coffee break Novel functional programs/environment adapted immunity immune cells with extended functional capacities. Chair: Andreas Mackensen, Wolfgang Herr Chair: Thomas Blankenstein We are looking forward to welcoming you for two exciting 11:35 am Engineering Specifi city and Function 09:00 am Keynote lecture: Conversion of of T cells effector T cells into regulatory T cells days in the beautiful city of Regensburg! Hans Stauss Shimon Sakaguchi 12:05 pm The next wave of CAR T cells for cancer Chair: Michael von Bergwelt, André Gessner On behalf of the board of directors Marcela Maus 10:00 am Deciphering the Immune Landscape of Human 12:35 pm Synthetic Targeting and Logic-Gated Orthogo- nal Outputs In the Context of CAR T Cell Immu- Cancer Microenvironment notherapy of Cancer Massimiliano Pagani Philipp Beckhove Michael Jensen 10:30 am Ontogeny of dendritic cells and Macrophages: (Director RCI) 01:05 pm Targeting Metastasis in a Cold Tumor with T From Development to Functions Cell Receptor Based Immunotherapy Florent Ginhoux Stefan Burdach 11:00 am Coffee break 01:20 pm Lunch & poster session Chair: Martin Bornhäuser, Matthias Edinger 02:30 pm - 04:30 pm Afternoon session: 11:30 am Treg cells in non-lymphoid tissues Cell therapy: new concepts Markus Feuerer Chair: Matthias Theobald, Markus Feuerer 12:00 pm Learning cellular differentiation pathways from 02:30 pm Harnessing the miRNA-epigenetic regulatory in vivo lineage tracing of T cells and hemato- circuitry to enhance CD8+ T cell antitumor poietic stem cells immunity Thomas Höfer Luca Gattinoni 12:30 pm Bioinformatics approaches to understand the 03:00 pm CARs, TRUCKs and beyond: the next generation interaction of cancer with the immune system of redirected T cells Benedikt Brors Hinrich Abken 01:00 pm Closing remarks 03:30 pm Engineering regulatory T cell specifi city in Philipp Beckhove autoimmunity and transplantation Megan Levings Farewell & lunch Speakers / Sponsors General Information / Registration SPITZE IN DER MEDIZIN. MENSCHLICH IN DER BEGEGNUNG. Speakers & Chairs Program Committee Hinrich Abken Hinrich Abken Genetic Immunotherapy Chair for Genetic Immunotherapy RCI Regensburg Center for Interventional Immunology c/o University Hospital Regensburg, Germany RCI Regensburg Center for Interventional Immunology Thomas Blankenstein c/o University Hospital Regensburg, Germany Charité Berlin - Universitätsmedizin Berlin Philipp Beckhove Institut für Immunologie, Berlin Chair for Interventional Immunology Martin Bornhäuser RCI Regensburg Center for Interventional Immunology Universitätsklinikum Carl Gustav Carus, Dresden Benedikt Brors c/o University Hospital Regensburg, Germany Applied Bioinformatics Matthias Edinger Deutsches Krebsforschungszentrum, Heidelberg Department of Internal Medicine III Matthias Edinger University Hospital Regensburg, Germany Department of Internal Medicine III University Hospital Regensburg, Germany Markus Feuerer Hermann Einsele Chair for Immunology Medizin II RCI Regensburg Center for Interventional Immunology Universitätsklinikum Würzburg, Würzburg c/o University Hospital Regensburg, Germany Markus Feuerer Immunology Venue RCI Regensburg Center for Interventional Immunology Thon-Dittmer-Palais, Haidplatz 8, c/o University Hospital Regensburg, Germany 93047 Regensburg, Germany Katharina Fleischhauer Institut für Zelltherapeutische Forschung Sponsors Universitätsklinikum Essen, Essen Becton Dickinson GmbH 1.000 € Tudor Fulga Genome Engineering and Synthetic Biology Celgene GmbH 1.500 € University of Oxford, Oxford CellGenix GmbH 2.000 € Luca Gattinoni ChemoMetec 1.000 € Experimental Transplantation and Immunology Janssen-Cilag GmbH 3.000 € National Cancer Institute, Bethesda Miltenyi Biotec GmbH 2.000 € André Gessner Institut für Mikrobiologie und Hygiene Novartis Pharma GmbH 2.000 € Universitätsklinikum Regensburg, Regensburg TPP Techno Plastic Products 1.000 € Florent Ginhoux Performance for booth fee and advertising purposes. Ontogeny and Differentiation of Macrophages Cells Photographs and fi lm recordings will be made during this event. Singapore Immunology Network (SLgN), Singapore These serve purposes of documentation and will also be used Wolfgang Herr Klinik und Poliklinik für Innere Medizin III for the University Hospital’s publicity work. If you wish to register Universitätsklinikum Regensburg, Regensburg an objection, please contact us on [email protected] by the day Thomas Höfer of the event at the latest. Theoretical Systems Biology (B086) Deutsches Krebsforschungszentrum, Heidelberg Online-Registration Michael Jensen www.congress-registration.ukr.de Ben Towne Center for Childhood Cancer Research Center for Childhood Cancer Research, Seattle Date Carl June July 17th - 18th 2019 Pathology and Laboratory Medicine Perelman School of Medicine at University of Pennsylvania, Philadelphia Conference Fee Ulrike Köhl Industry participants incl. social program & dinner 400 € Institute of Cellular Therapeutics Industry participants excl. social program & dinner 350 € Hannover Medical School, Hannover Megan Levings Regular participation incl. social program & dinner 250 € Faculty of Medicine/Department of Surgery Regular participation excl. social program & dinner 200 € BC Children`s Hospital Research Institute, Vancouver PhD Students incl. social program & dinner 125 € Andreas Mackensen UKR, UR free of charge (conference dinner € 45,-) Regensburg Center for Interventional Immunology RCI Medizinische Klinik 5 - Hämatologie und Internistische Onkologie Registration mandatory prior to the symposium. Universitätsklinikum Erlangen, Erlangen Marcela Maus Participants limited to 150. First come, fi rst serve. Cellular Immunotherapy Organisation MGH Center for Cancer Research, Charlestown Massimiliano Pagani University Hospital Regensburg International RCI symposium Medical Biotechnology and Translational Medicine Conference Division UK3, Britta Haseneder Instituto Nazionale Genetica Moecolare (INGM), Milano Franz-Josef-Strauß-Allee 11 Shimon Sakaguchi 93053 Regensburg, Germany Synthetic Immunology and environ- Experimental Immunology Phone: +49 (0)941 944-4230 | Fax: +49 (0)941 944-4233 WPI Immunology Frontier Research Center, Osaka University, Osaka Dolores Schendel [email protected] ment-adapted redirection of T cells Chief Executive Offi cer and Chief Scientifi c Offi cer Registration conditions Medigene AG, Munich Thon-Dittmer-Palais Regensburg, Germany Michael Schmitt After your successful registration you will receive a payment request concerning your parti- Universitätsklinikum Heidelberg, Heidelberg cipation fee during the next days by email. Once registered your registration is binding. All payments must be made prior to the conference. Participation fees are due upon receipt July 17th - 18th 2019 Hans Stauss of payment request without deduction. Please transfer the participation fee amount before Division of Infection and Immunity the event date. In case of a cancellation the cancellation statement must be in writing. The Institute of Immunity and Transplantation, London following processing fees apply: 8-3 working days before the event 50% of participation fee. Matthias Theobald In case of too late cancellation or absence without written cancellation the entire fee will be Universitätsmedizin Mainz charged. A substitute participant may be submitted at any time. ukr.de III. Medizinischen Klinik,Mainz Michael von Bergwelt MedizinischenKlinik und Poliklinik III Photo and rights: RCI LMU Klinikum der Universität München, München July 2019.
Load more

Recommended publications
  • 18Th World Vaccine Congress Agenda: Day 1 – Tuesday 10Th October 2017
    18th World Vaccine Congress Agenda: Day 1 – Tuesday 10th October 2017 Plenary Session ROOM: RUBI/ZAFIR 08:50 Chair’s opening remarks Dr Gregory Poland, Director, Mayo Clinic 09:00 Opening plenary discussion: Creating a new strategy - How does the current global outbreak response system need to change? Moderator: Dr Gregory Poland, Director, Mayo Clinic Speakers: Dr Marie-Paule Kieny, Former Assistant Director-General - Health Systems and Innovation, WHO Richard Hatchett, CEO, CEPI Prof Helen Rees, Chair and Executive Director, Wits Reproductive Health and HIV Institute 10:00 Maternal immunisation: Where do we stand and how do we use vaccines, antivirals and antibodies – What’s the strategy? Francesca Ceddia, VP, Head Global Medical Affairs Vaccines, GSK Vaccines 10:30 Break the ice with your peers and exchange business cards in the conference room 10:40 Morning Networking Break Therapeutic Vaccines Track Respiratory Vaccines Track ONE HEALTH with ROOM: RUBI ROOM: ZAFIR ROOM: ROSSINI 11:40 Chair’s opening remarks Chair’s opening remarks Chair’s opening remarks Dr Emmett V. Schmidt, Exec Director, Clinical Dr Gregory Poland, Director, Mayo Clinic Nathalie Garcon, CEO/CSO, BIOASTER Research, Merck Research Laboratories - Oncology Therapeutic & Immunotherapy Vaccines Influenza Vaccines Discovery and Drivers for Emerging Diseases 11:45 Why haven't Alzheimer's vaccines succeeded yet? Clinical development of a nasal inactivated influenza Bringing together experts in human and animal health Professor Nikolai Petrovsky, Flinders University vaccine
    [Show full text]
  • 2020 Stanford Bio-X Fellowship Brochure
    STANFORD BIO-X PHD FELLOWSHIPS 2020 Stanford Bio-X Fellows Group Photo 2019 The Stanford Bio-X Graduate Fellowships The mission of the Stanford Bio-X Program is to catalyze discovery by crossing the boundaries between disciplines to bring interdisciplinary solutions, to create new knowl- edge of biological systems, and to benefit human health. Since it was established in 1998, Stanford Bio-X has charted a new approach to life science research by bringing together clinical experts, life scientists, engineers, and others to tackle the complexity of the human body. Currently over 980 Stanford Faculty and over 8,000 students, postdocs, researchers, etc. are affiliated with Stanford Bio-X. The generous support from donors, including the Bowes Foundation, enables the program to remain successful—at any given time, Stanford Bio-X is training at least 60 Ph.D fellows, and Fall 2020 brings 21 new fellows to the program. The Stanford Bio-X Graduate Fellowship Program was started to answer the need for training a new breed of visionary science leaders capable of crossing the bound- aries between disciplines in order to bring novel research endeavors to fruition. Since its inception in 2004, the three-year fellowships, including the Stanford Bio-X Bowes Fellowships and the Bio-X Stanford Interdisciplinary Graduate Fellowships (Bio-X SIGFs), have provided 318 graduate students with awards to pursue interdisciplinary research and to collaborate with multiple mentors, enhancing their potential to gen- erate profound transformative discoveries. Stanford Bio-X Fellows become part of a larger Stanford Bio-X community of learning that encourages their further networking and development.
    [Show full text]
  • Synthetic Immunology: Hacking Immune Cells to Expand Their Access Provided by University of California - San Francisco UCSF on 10/10/18
    IY35CH09-Lim ARI 6 April 2017 15:15 ANNUAL REVIEWS Further Click here to view this article's online features: • Download figures as PPT slides • Navigate linked references • Download citations Synthetic Immunology: • Explore related articles • Search keywords Hacking Immune Cells to Expand Their Therapeutic Capabilities Kole T. Roybal1 and Wendell A. Lim2 1Parker Institute for Cancer Immunotherapy, Department of Microbiology and Immunology, University of California, San Francisco, California 94143; email: [email protected] 2Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158; email: [email protected] Annu. Rev. Immunol. 2017. 35:229–53 Keywords The Annual Review of Immunology is online at synthetic biology, immunotherapy, engineered immune cells, T cells, immunol.annualreviews.org synthetic Notch, chimeric antigen receptors https://doi.org/10.1146/annurev-immunol- 051116-052302 Abstract Copyright c 2017 by Annual Reviews. The ability of immune cells to survey tissues and sense pathologic insults All rights reserved and deviations makes them a unique platform for interfacing with the body Annu. Rev. Immunol. 2017.35:229-253. Downloaded from www.annualreviews.org and disease. With the rapid advancement of synthetic biology, we can now engineer and equip immune cells with new sensors and controllable thera- peutic response programs to sense and treat diseases that our natural immune Access provided by University of California - San Francisco UCSF on 10/10/18. For personal use only. system cannot normally handle. Here we review the current state of engi- neered immune cell therapeutics and their unique capabilities compared to small molecules and biologics.
    [Show full text]
  • Andreas Zingg – Curriculum Vitae
    Andreas Zingg Curriculum Vitae Education 2011–2013 Basic Studies in Biology, University of Zurich, Zurich 2013–2015 Bachelor of Science ETH in Biotechnology, ETH Zurich, Basel 2015–2017 Master of Science ETH in Biotechnology, ETH Zurich, Basel Research Experience 06/2020 Doctoral Student - present University Hospital, Basel Cancer Immunotherapy, Prof. Dr. Heinz Läubli Project Titel: Redirection of immune cells to glycan antigens on tumour cells In the scope of this project, CAR-T cells will be developed that target the Sialyl-Thomsen-Nouveau antigen which is expressed on the majority of tumours. Various strategies will be evaluated to counteract the immunosuppressive tumour environment. Finally, this project should pave the way towards clinical trials with anti-STn directed, armored fourth generation CAR-T cells. 03/2019 Research Associate - 05/2020 Memo Therapeutics AG, Schlieren MTx is an ETH spin-off with 10 employees. It is an innovator in the field of antibody discovery based on microfluidics and its program includes targets in infectious diseases and immuno- oncology. I was responsible for most cell culture related experiments such as antibody library screening, assay development and routine cell culture but also supported the team in various molecular biological tasks. Specifically, I was trained in operating the company’s proprietary microfluidic system for emulsion PCR, cell-encapsulation and droplet sorting. Furthermore, for MTx’ screening project for SARS-CoV-2 neutralizing antibodies, I developed a pseudovirus assay to evaluate promising antibody candidates. 02/2018 Internship: Discovery of cell-penetrating antibodies - 12/2018 UCB Celltech, Slough UCB is multinational biopharmaceutical company with roughly 8’000 employees and a revenue of almost 5 billion euro.
    [Show full text]
  • R E P Or T in G S C Ien C E & T E C Hn O Log Y F O R H E a Lt H
    | MARCH 2015 MISROCK FOUNDATION FOR HEALTH ETH ZÜRICH FOUNDATION SCIENCE & TECHNOLOGY SCIENCE & TECHNOLOGY REPORTING Professor Sai Reddy is one of 17 professors at the D-BSSE in Basel. HIGHLIGHT PROFESSOR SAI REDDY IS A PROJECT LEADER AT THE NCCR MOLECULAR ENGINEERING Molecular Systems Engineering is a National Centre of Competence in Research (NCCR) funded by the Swiss National Science Foundation (SNSF) and headed by the University of Basel and ETH Zürich. This particular NCCR combines the disciplines biology, chemistry and physics with bioinformatic and engineering. The goal is to engineer and to combine molecular modules to design “molecular factories”. These molecular factories will be used for industrial production or to control cellular systems in health and disease. Professor Reddy is one of 17 professors at the Department of Biosystems Science & Engineering (D-BSSE) in Basel, Switzerland and one of the project leaders at the NCCR Molecular Engineering. He teaches Master students in Biomolecular Engineering & Immunotechnology and PhD students assigned to the joint ETH – University of Zurich Graduate Programme on Microbology & Immunology. ACKNOWLEDGING OUR PARTNERS The Laboratory for Systems and Synthetic Immunology and the professorship of Sai Reddy is made possible by the generous endowment of the S. Leslie Misrock Foundation. 02 ETH ZÜRICH FOUNDATION | MARCH 2015 The new president: The new rector: The new vice president of Lino Guzzella Sarah Springman research and corporate rela- tions: Detlef Günther Lino Guzzella, former rector of ETH Sarah Springman succeeds Lino Detlef Günther will be responsible Zurich (2012–2014) is Ralph Eichler’s Guzzella as rector. After Heidi Wun- for strategic research supervision successor.
    [Show full text]
  • International RCI Symposium
    Speakers / Sponsors General Information / Registration SPITZE IN DER MEDIZIN. MENSCHLICH IN DER BEGEGNUNG. Speakers Program Committee Hinrich Abken Hinrich Abken Genetic Immunotherapy Chair for Genetic Immunotherapy RCI Regensburg Center for Interventional Immunology RCI Regensburg Center for Interventional Immunology c/o University Hospital Regensburg, Germany c/o University Hospital Regensburg, Germany Benedikt Brors Applied Bioinformatics Philipp Beckhove Deutsches Krebsforschungszentrum, Heidelberg Chair for Interventional Immunology Matthias Edinger RCI Regensburg Center for Interventional Immunology Department of Internal Medicine III c/o University Hospital Regensburg, Germany University Hospital Regensburg, Germany Matthias Edinger Markus Feuerer Department of Internal Medicine III Immunology University Hospital Regensburg, Germany RCI Regensburg Center for Interventional Immunology c/o University Hospital Regensburg, Germany Markus Feuerer Tudor Fulga Chair for Immunology Genome Engineering and Synthetic Biology RCI Regensburg Center for Interventional Immunology University of Oxford, Oxford c/o University Hospital Regensburg, Germany Luca Gattinoni Venue Experimental Transplantation and Immunology National Cancer Institute, Bethesda Thon-Dittmer-Palais, Haidplatz 8, Florent Ginhoux 93047 Regensburg, Germany Ontogeny and Differentiation of Macrophages Cells Suggested hotels Singapore Immunology Network (SLgN), Singapore Achat Plaza Hotel Thomas Höfer www.achat-hotels.de | Phone: +49 (0)941 58400 0 Theoretical Systems Biology (B086)
    [Show full text]
  • Engineered Th17 Cell Differentiation Using a Photo-Activatable Immune Modulator
    bioRxiv preprint doi: https://doi.org/10.1101/719021; this version posted July 30, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Engineered Th17 cell differentiation using a photo-activatable immune modulator Bibudha Parasar1 and Pamela V. Chang*2,3,4 1Department of Chemistry and Chemical Biology; 2Department of Microbiology and Immunology, 3Center for Immunology, 4Cornell Institute of Host-Microbe Interactions & Disease, Cornell University, Ithaca, NY 14853 * Correspondence: [email protected] Abstract T helper 17 (Th17) cells, an important subset of CD4+ T cells, help to eliminate extracellular infectious pathogens that have invaded our tissues. Despite the critical roles of Th17 cells in immunity, how the immune system regulates the production and maintenance of this cell type remains poorly understood. In particular, the plasticity of these cells, or their dynamic ability to trans-differentiate into other CD4+ T cell subsets, remains mostly uncharacterized. Here, we report a synthetic immunology approach using a photo-activatable immune modulator (PIM) to increase Th17 cell differentiation on demand with spatial and temporal precision to help elucidate this important and dynamic process. In this chemical strategy, we developed a latent agonist that, upon photochemical activation, releases a small-molecule ligand that targets the aryl hydrocarbon receptor (AhR) and ultimately induces Th17 cell differentiation. We used this chemical tool to control AhR activation with spatiotemporal precision within cells and to modulate Th17 cell differentiation on demand by using UV light illumination. We envision that this approach will enable an understanding of the dynamic functions and behaviors of Th17 cells in vivo during immune responses and in mouse models of inflammatory disease.
    [Show full text]
  • ANNUAL REPORT 2019 Unding Brave and Bold
    ANNUAL REPORT 2019 unding brave and bold. Cancer. No disease in F the history of medicine has proven more elusive and resilient. It defies logic. It’s unpredictable. It hides in plain sight. It evolves. And it’s soon to be the number one killer in America. The very nature of cancer is why, at the Damon Runyon Cancer Research Foundation, OUR we believe that only by pursuing And we support them the and investing in the most best way we know how— with audacious and ambitious ideas the money they need to bring will we achieve victory over their ideas from whiteboards humankind’s deadliest enemy. to reality. The funding and freedom to pursue theories, Our research focus is singular: concepts and strategies that high-risk, high-reward. others are not brave or bold enough to bet their careers on. Research that others might deem radical or believe to be Brave and bold. reaching too far. Research that has a good chance of failure, but That’s where the Damon at the same time has a chance to Runyon Cancer Research fundamentally change the game. Foundation invests. That’s where we believe the answers Who does that kind of will come from. research? Brave and bold. Young scientists with the brilliance and unbridled passion The only two words that will to push boundaries and break beat cancer. rules. People with the incredible brainpower to earn millions of dollars on Wall Street or in Silicon Valley, but who have chosen to take a different path, a path that could instead save millions of lives.
    [Show full text]
  • Regulated Expansion and Survival of Chimeric Antigen Receptor-Modified T Cells Using Small Molecule-Dependent Inducible Myd88/CD40
    Original Article Regulated Expansion and Survival of Chimeric Antigen Receptor-Modified T Cells Using Small Molecule-Dependent Inducible MyD88/CD40 Aaron E. Foster,1 Aruna Mahendravada,1,2 Nicholas P. Shinners,1,2 Wei-Chun Chang,1 Jeannette Crisostomo,1 An Lu,1 Mariam Khalil,1 Eva Morschl,1 Joanne L. Shaw,1 Sunandan Saha,1 MyLinh T. Duong,1 Matthew R. Collinson-Pautz,1 David L. Torres,1 Tania Rodriguez,1 Tsvetelina Pentcheva-Hoang,1 J. Henri Bayle,1 Kevin M. Slawin,1 and David M. Spencer1 1Bellicum Pharmaceuticals, Houston, TX 77030, USA Anti-tumor efficacy of T cells engineered to express chimeric Mechanistic studies aimed at understanding the effect of lymphode- antigen receptors (CARs) is dependent on their specificity, sur- pleting regimens (chemotherapy and total body irradiation [TBI]) on vival, and in vivo expansion following adoptive transfer. Toll- T cell proliferation have shown that Toll-like receptor (TLR) activa- like receptor (TLR) and CD40 signaling in T cells can improve tion via lipopolysaccharide (LPS) liberated from gut flora contributes persistence and drive proliferation of antigen-specific CD4+ to the expansion of T cells following adoptive transfer.6,7 TLRs are and CD8+ T cells following pathogen challenge or in graft- widely expressed on most, if not all, nucleated cells, including versus-host disease (GvHD) settings, suggesting that these cos- T cells,8,9 and engagement of TLRs by agonists induces costimulatory timulatory pathways may be co-opted to improve CAR-T cell pathways in T cells that decrease the T cell receptor
    [Show full text]
  • Targeted Cellular Micropharmacies: Cells Engineered for Localized Drug Delivery
    cancers Review Targeted Cellular Micropharmacies: Cells Engineered for Localized Drug Delivery 1 1,2, 1,3, 1,3, Thomas J. Gardner , Christopher M. Bourne y , Megan M. Dacek y, Keifer Kurtz y , 1, 1, 1,3, 1,4, Manish Malviya y , Leila Peraro y , Pedro C. Silberman y , Kristen C. Vogt y , Mildred J. Unti 3 , Renier Brentjens 5 and David Scheinberg 1,3,5,* 1 Molecular Pharmacology Program, Sloan Kettering Institute, New York, NY 10065, USA; [email protected] (T.J.G.); [email protected] (C.M.B.); [email protected] (M.M.D.); [email protected] (K.K.); [email protected] (M.M.); [email protected] (L.P.); [email protected] (P.C.S.); [email protected] (K.C.V.) 2 Immunology Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA 3 Pharmacology Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA; [email protected] 4 Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA 5 Department of Medicine, Memorial Hospital, New York, NY 10065, USA; [email protected] * Correspondence: [email protected] These authors contributed equally to this work. y Received: 17 July 2020; Accepted: 2 August 2020; Published: 5 August 2020 Abstract: The recent emergence of engineered cellular therapies, such as Chimeric antigen receptor (CAR) CAR T and T cell receptor (TCR) engineered T cells, has shown great promise in the treatment of various cancers. These agents aggregate and expand exponentially at the tumor site, resulting in potent immune activation and tumor clearance.
    [Show full text]
  • Cancer Immunotherapy: Are We There Yet? Zihai Li1*, Lieping Chen2 and Mark P Rubinstein1
    Li et al. Experimental Hematology & Oncology 2013, 2:33 http://www.ehoonline.org/content/2/1/33 Experimental Hematology & Oncology REVIEW Open Access Cancer immunotherapy: are we there yet? Zihai Li1*, Lieping Chen2 and Mark P Rubinstein1 Abstract The immune system is the built-in host defense mechanism against infectious agents as well as cancer. Protective immunity against cancer was convincingly demonstrated in the 1940s with syngeneic animal models (JNCI 18:769-778, 1976; Cancer Immun 1:6, 2001). Since then, the last century’s dream has been to effectively prevent and cure cancers by immunological means. This dream has slowly but surely become a reality (Nature 480:480-489, 2011). The successful examples of immunoprophylaxis and therapy against cancers include: (i) targeted therapy using monoclonal antibodies (Nat Rev Cancer 12:278-287, 2012); (ii) allogeneic hematopoietic stem cell transplantion to elicit graft-versus-cancer effect against a variety of hematopoietic malignancies (Blood 112:4371- 4383, 2008); (iii) vaccination for preventing cancers with clear viral etiology such as hepatocellular carcinoma and cervical cancer (Cancer J Clin 57:7-28, 2007; NEJM 336:1855-1859, 1997); (iv) T cell checkpoint blockade against inhibitory pathways including targeting CTLA-4 and PD-1 inhibitory molecules for the treatment of melanoma and other solid tumors (NEJM 363:711-723, 2010; NEJM 366:2443-2454, 2012; NEJM 369:122-133, 2013; NEJM 366:2455-2465, 2012); (v) antigen-pulsed autologous dendritic cell vaccination against prostate cancer (NEJM 363:411-422, 2010); and (vi) the transfer of T cells including those genetically engineered with chimeric antigen receptors allowing targeting of B cell neoplasms (NEJM 365:725-733, 2011; NEJM 368:1509-1518, 2013; Blood 118:4817-4828, 2013; Sci Transl Med 5:177ra138, 2013).
    [Show full text]
  • Newly Identified T Cell Subsets in Mechanistic Studies of Food Immunotherapy
    Newly identified T cell subsets in mechanistic studies of food immunotherapy Vanitha Sampath, Kari C. Nadeau J Clin Invest. 2019;129(4):1431-1440. https://doi.org/10.1172/JCI124605. Review Series Allergen-specific immunotherapy has shown promise for the treatment of food allergy and is currently being evaluated in clinical trials. Although immunotherapy can induce desensitization, the mechanisms underlying this process are not completely understood. Recent advances in high-throughput technologies along with concomitant advances in data analytics have enabled monitoring of cells at the single-cell level and increased the research focus on upstream cellular factors involved in the efficacy of immunotherapy, particularly the role of T cells. As our appreciation of different T cell subsets and their plasticity increases, the initial simplistic view that restoring Th1/Th2 balance by decreasing Th2 or increasing Th1 responses can ameliorate food allergy is being enhanced by a more complex model involving other T cell subsets, particularly Tregs. In this Review, we focus on the current understanding of T cell functions in food allergy, tolerance, and immunotherapy. Find the latest version: https://jci.me/124605/pdf The Journal of Clinical Investigation REVIEW SERIES: ALLERGY Series Editor: Kari Nadeau Newly identified T cell subsets in mechanistic studies of food immunotherapy Vanitha Sampath1 and Kari C. Nadeau1,2 1Sean N. Parker Center for Allergy and Asthma Research and 2Division of Pulmonary and Critical Care Medicine, Stanford University, Stanford, California, USA. Allergen-specific immunotherapy has shown promise for the treatment of food allergy and is currently being evaluated in clinical trials. Although immunotherapy can induce desensitization, the mechanisms underlying this process are not completely understood.
    [Show full text]