| MARCH 2015 MISROCK FOUNDATION FOR HEALTH ETH ZÜRICH FOUNDATION SCIENCE & TECHNOLOGY SCIENCE & TECHNOLOGY REPORTING

Professor Sai Reddy is one of 17 professors at the D-BSSE in Basel.

HIGHLIGHT PROFESSOR SAI REDDY IS A PROJECT LEADER AT THE NCCR MOLECULAR ENGINEERING Molecular Systems Engineering is a National Centre of Competence in Research (NCCR) funded by the Swiss National Science Foundation (SNSF) and headed by the University of Basel and ETH Zürich. This particular NCCR combines the disciplines biology, chemistry and physics with bioinformatic and engineering. The goal is to engineer and to combine molecular modules to design “molecular factories”. These molecular factories will be used for industrial production or to control cellular systems in health and disease. Professor Reddy is one of 17 professors at the Department of Biosystems Science & Engineering (D-BSSE) in Basel, Switzerland and one of the project leaders at the NCCR Molecular Engineering. He teaches Master students in Biomolecular Engineering & Immunotechnology and PhD students assigned to the joint ETH – University of Zurich Graduate Programme on Microbology & Immunology.

ACKNOWLEDGING OUR PARTNERS The Laboratory for Systems and Synthetic Immunology and the professorship of Sai Reddy is made possible by the generous endowment of the S. Leslie Misrock Foundation. REPORTING SCIENCE & TECHNOLOGY FOR HEALTH 02 The new president: edge in potential future scientists. scientists. future potential in edge knowl fire the for spark as well as non-scientist educate would that away in were presented researchers, manifold and current research topics of presentations to short Thanks genome. rus vi acomplete assemble or themselves crystals protein manufacture could they a microscope, under fly of afruit development the observe could adults and adults young children, Older shop. work ahandicraft and show amagic was there above, and years of five children small For dren. chil also but adults target only not did specifically event The research. applied or research damental fun it –be for science of ages all to excite people managed and success abig was of Basel versity systems in and the Basel Biozentrum of the Uni of Bio Department of the Day House Open The 2014 Day House Open D-BSSE and thepublic. general bodies government authorities, political with relations fostering include also duties core His Board. Executive the of rest the with agreement in egy and determinesthe budget the strat of allocation the on decides fessors, of pro appointment the prepares He 2015. January from university for the responsibility political and legal bear will he rich Zu of ETH president As successor. Eichler’s (2012–2014) Ralph is Zurich of ETH rector former Guzzella, Lino Lino Guzzella - - - with secondary schools. with secondary also responsible for collaboration is She process. examination the ing includ matters, study-related aging man and organising and levels all at to courses for admission sponsible re is rector The portfolio. teaching of the charge in member Board Executive the be will tor, Springman rec As position. this to hold woman second the is she derli-Allenspach, Wun rector. as Heidi Guzzella After Sarah Springman succeeds Lino Sarah Springman rector: new The ------A researcher is educating future scientists future educating is A researcher ETH ZÜRICH FOUNDATION ZÜRICH ETH - - - - - plication of ETH Zurich’s research research Zurich’s of ETH plication ap the on afocus with technology, and as funding well as the transfer of supervision research for strategic responsible be will Günther Detlef Detlef Günther tions: andresearch corporate rela of president vice new The sent Board. the Executive laboration and with repre industry of col charge in be will He results. | MARCH 2015 |MARCH - - - - chemistry and chemistry, as well re as translational chemistry virology, therapy, gene parasitology, cell biology, bio researchers in theof field immunology, microbiology, for basic of interaction aplatform provides network The ment strengthened. will be develop clinical and preclinical between interface the at research translational and connected get will eases dis andimmune neurodegenerative pathology, diseases, of infectious areas the in research clinical and or parasites basic comprehensively. this network, Via tious diseases caused by viruses, , fungi, prions infec acute and chronic to investigate mandate the has Immunity’ and ‘Infection network The science. puter com and immunology medicine, of biology, methods advanced using molecules and cells tissues, isms, level of organ the at pathogens existing tois research diseases, spreading from to us protect strategy tainable sus and A central are available. drugs no which against pathogens emerging newly by or drugs, conventional to resistant have become that pathogens well-known by caused are either They world. aglobalized in rapidly Hochschulmedizin Zürich. Infectious diseases spread of the part is Immunity’ and ‘Infection network The Zurich” Immunity and “Infection Network The apy. immunother and biotechnology in for applications cells immune to related engineering of research area new focus a established recently has group Reddy’s Furthermore, immunobiology. basic studying and vaccination, following responses of immune characterization discovery, for therapeutic applied is technology This of . and bioinformatic analysis sequencing related thedeveloping and building core to technology the next-generation in gains substantial made has group member. The staff one and students three students, PhD three searchers, re postdoctoral five including members, 13 counts staff today group Reddy’s set-up, after years two only Within immunotherapy. cellular and vaccination, biotechnology, in for applications reprogramming cell immune and team’s to immunogenomics is use The mission core response. immune control subsequently and cells immune to reprogram methods engineering cellular and molecular uses immunology ic sequencing, technologies bioinformatics,high-throughput such DNA as and next-generation proteomics. Synthet of use the includes This response. immune of the understanding quantitative and comprehensive amore gaining on focused is immunology . and biotechnology, molecular of genomics, intersection the at is which immunology, synthetic and systems of fields emerging the in research conducts group Reddy’s Professor PORTRAIT FOUNDATION ZÜRICH ETH RESEARCH OF PROFESSOR REDDY AND HIS TEAM HIS AND REDDY PROFESSOR OF RESEARCH | MARCH 2015 |MARCH ------Infection and Immunity Zurich Immunity and Infection Zurich” network. Immunity and “Infection of the amember is Reddy Sai in therapy gene humans. of application for asuccessful foundations to the lay and infectiouspreventive diseases, against possibilities andand thereby therapeutic developing new diagnostic, interactions of host–pathogen at understanding a better aims groups of these collaboration The Zurich. Hospital Children’s University and Hospital University the Zurich, ETH and of Zurich University of the groups research 65 currently comprises network The infectious diseases. and andsearchers in clinicians theof field immunology - - - 03 REPORTING SCIENCE & TECHNOLOGY FOR HEALTH REPORTING SCIENCE & TECHNOLOGY FOR HEALTH 04 • • • • RECENT KEY PUBLICATIONS ETH Zurich, Main building Main Zurich, ETH Tag academicus) (Dies ETH 2015 21 November building Main Zurich, ETH Day Industry 2015 August 25 building Main Zurich, ETH Thanks Giving 11 2015 June EVENTS 70-27. 1720 with biomaterials. tion principles regulating immunomodulation S.T. and Khan (2014) T.A. Reddy sequencing next-generation for methods generation library antibody of tion S.T. Reddy U. Haessler, M.W. Pogson, Friedensohn, S. Cook, S.C. Hellmann, I. V.U. Khan, Menzel, T.A. Greiff, Immunology.BMC iable gene from repertoires immunized mice, var and clonal antibody of sequencing eration the robustness and of reproducibility next-gen S.T. (2014) Reddy Hellmann, I. Khan, T.A. M.W. Pogson, Friedensohn, S. V. Cook, U. U. S.C. Haessler, Greiff, Menzel, ONE. ble regions with subtype identification varia immunoglobin human of sequencing put (2014) Trkola, Huber A. M. Günthard, S.T. T. O. Zagordi, Schanz, Liechti, M. H.F. Reddy,

Comparative analysis and optimiza

Quantitative assessment of Acta Biomaterialia, Acta 10(4):

. PLoS One (2014). One . PLoS Immunomodula High-through www.ethz-foundation.ch | Corinna Contact: Adler, [email protected] , PLoS PLoS , ------• • • for team: his funding tive competi acquiring in successful was Reddy Professor RESEARCH FOR FUNDING SOLID • • • • tion of antibody variable light and heavy region pair region heavy and light variable of antibody tion predic for silico in algorithm based chine-learning Grant: ETH Research ment develop to guide infection viral in evolution antibody neutralizing of broadly determinants ing VaccineSwiss (co-PI): Institute Research analysis biology treatments by for comprehensive systems cancer –immunotherapy conjugate drug antibody ergistic (co-PI): Grant Transfer SystemsX rial pathogens rial bacte against immunodiagnostics and of in the development approaches tems immunology Marie Heim-Vögtlin Fellowship: Zurich of University the and Zurich ETH at Investigators RTD: SystemsX.ch repertoires antibody cell B of whole analysis bioinformatics and quencing se DNA next-generation via antibodies apeutic Grant: Project CTI responses Bcell memory of polyclonal sis Grant: Project SNF ing ETH ZÜRICH FOUNDATION ZÜRICH ETH Total amount: 120’000 CHF Total 120’000 amount: 09.2014-12.2016 Duration: CHF Total 100’000 amount: 04.2015-04.2016 Duration: Total Amount: 246’000 CHF Total 246’000 Amount: –02.2015 02.2013 Duration: To: researcher Ulrike Postdoctoral Haessler, CHF Total 1’379’000 Amount: –03.2017 03.2013 Duration: CHF Total 454’000 Amount: 07.2013Duration: –07.2015 Therapeutics Investigators: NBE Industrial Co-Principal CHF Total 529’800 Amount: –06.2016 06.2013 Duration: CHF Total 222’400 amount: 04.2014-04.2017 Duration: Development ther of functional AntibodyX with Co-Principal Co-Principal with AntibodyX Quantitative molecular analy molecular Quantitative Development of a ma a of Development | MARCH 2015 |MARCH Evaluating syn Evaluating Utilizing sys Defin ------