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Andreas Zingg – Curriculum Vitae

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Andreas Zingg – Curriculum Vitae Andreas Zingg Curriculum Vitae Education 2011–2013 Basic Studies in Biology, University of Zurich, Zurich 2013–2015 Bachelor of Science ETH in Biotechnology, ETH Zurich, Basel 2015–2017 Master of Science ETH in Biotechnology, ETH Zurich, Basel Research Experience 06/2020 Doctoral Student - present University Hospital, Basel Cancer Immunotherapy, Prof. Dr. Heinz Läubli Project Titel: Redirection of immune cells to glycan antigens on tumour cells In the scope of this project, CAR-T cells will be developed that target the Sialyl-Thomsen-Nouveau antigen which is expressed on the majority of tumours. Various strategies will be evaluated to counteract the immunosuppressive tumour environment. Finally, this project should pave the way towards clinical trials with anti-STn directed, armored fourth generation CAR-T cells. 03/2019 Research Associate - 05/2020 Memo Therapeutics AG, Schlieren MTx is an ETH spin-off with 10 employees. It is an innovator in the field of antibody discovery based on microfluidics and its program includes targets in infectious diseases and immuno- oncology. I was responsible for most cell culture related experiments such as antibody library screening, assay development and routine cell culture but also supported the team in various molecular biological tasks. Specifically, I was trained in operating the company’s proprietary microfluidic system for emulsion PCR, cell-encapsulation and droplet sorting. Furthermore, for MTx’ screening project for SARS-CoV-2 neutralizing antibodies, I developed a pseudovirus assay to evaluate promising antibody candidates. 02/2018 Internship: Discovery of cell-penetrating antibodies - 12/2018 UCB Celltech, Slough UCB is multinational biopharmaceutical company with roughly 8’000 employees and a revenue of almost 5 billion euro. The biotechnology branch is focused on autoimmune and neurological diseases. I developed an innovative screening system for high-throughput discovery of cell-penetrating antibodies from human B-cells. In parallel, I improved previous methods for human B-cell culture and optimised protocols for antibody DNA-sequence recovery. I enjoyed working independently and planning my experiments by myself, thereby still receiving valuable inputs from my supervisors. 11/2016 Master Thesis: Rapid generation of stable hybridoma cell lines by targeted transgene - 08/2017 integration in the immunoglobulin locus ETH Zurich, Laboratory for Systems and Synthetic Immunology The goal of my project was to extend the use of the Plug-and-Display cell line from Pogson et al. (2016)1 by developing two cell lines with the help of the CRISPR/Cas9 system that have the following features: { Replacement of the murine heavy chain constant region with the human IgG version, thereby enabling rapid and stable expression of fully human antibodies of choice. { Changing the parental cell line into a protein expression system that allows simple and rapid detection of successfully, stably integrated expression cassettes. 04/2016 iGEM: A diagnostic tool for in vivo screening of biomarkers - 10/2016 ETH Zurich, Bioprocess Laboratory iGEM is an international student competition in synthetic biology. Our team was developing a bacterial diagnostic tool to measure inflammatory bowel disease related biomarkers in vivo. This included building and testing a complex genetic network, directed evolution of a repressor protein and comprehensible presentation of the generated data.2 09/2015 Research Project: Accurate and predictive antibody repertoire profiling by molecular - 04/2016 amplification fingerprinting ETH Zurich, Laboratory for Systems and Synthetic Immunology I adapted the protocol of accurate murine antibody repertoire sequencing, which was previously published by Khan et al. (2016)3, to human PBMC samples. This included adaptation and optimization of the procedure from isolation of mRNA to NGS-library preparation as well as the generation of customized synthetic cDNA sequencing references. Work Experience 03/2014 Squad Leader - 08/2014 Swiss Armed Forces, Berne and While doing my military service, I was responsible for training the recruits in NBC defence (especially 08/2017 in the field of sampling and decontamination) as well as teaching them the general military skills and - 11/2017 knowledge. This position brought a lot of responsibility with it and required good endurance but also taught me how to successfully deal with subordinates. Additionally, I had the possibility to acquire the certificate Leadership SVF. 09/2012 Assistant - 09/2014 Swiss Capital Group, Zurich During my studies, I was also working part-time as an assistant for an investment company. During this time, I was responsible for the following tasks: { Data Collection { Data Processing with MS Office { Quality Control 1 Pogson, Mark et al. “Immunogenomic Engineering of a Plug-and-(dis)play Hybridoma Platform.” Nature Communications 7 (2016): 12535. 2 http://2016.igem.org/Team:ETH_Zurich 3 Khan, Tarik A. et al. “Accurate and Predictive Antibody Repertoire Profiling by Molecular Amplification Fingerprinting.” Science Advances 2.3 (2016): e1501371..
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