Speakers / Sponsors General Information / Registration SPITZE IN DER MEDIZIN. MENSCHLICH IN DER BEGEGNUNG.

Speakers Program Committee Hinrich Abken Hinrich Abken Genetic Immunotherapy Chair for Genetic Immunotherapy RCI Regensburg Center for Interventional Immunology RCI Regensburg Center for Interventional Immunology c/o University Hospital Regensburg, Germany c/o University Hospital Regensburg, Germany Benedikt Brors Applied Bioinformatics Philipp Beckhove Deutsches Krebsforschungszentrum, Heidelberg Chair for Interventional Immunology Matthias Edinger RCI Regensburg Center for Interventional Immunology Department of Internal Medicine III c/o University Hospital Regensburg, Germany University Hospital Regensburg, Germany Matthias Edinger Markus Feuerer Department of Internal Medicine III Immunology University Hospital Regensburg, Germany RCI Regensburg Center for Interventional Immunology c/o University Hospital Regensburg, Germany Markus Feuerer Tudor Fulga Chair for Immunology Genome Engineering and RCI Regensburg Center for Interventional Immunology University of Oxford, Oxford c/o University Hospital Regensburg, Germany Luca Gattinoni Venue Experimental Transplantation and Immunology National Institute, Bethesda Thon-Dittmer-Palais, Haidplatz 8, Florent Ginhoux 93047 Regensburg, Germany Ontogeny and Differentiation of Macrophages Cells Suggested hotels Singapore Immunology Network (SLgN), Singapore Achat Plaza Hotel Thomas Höfer www.achat-hotels.de | Phone: +49 (0)941 58400 0 Theoretical Systems Biology (B086) Deutsches Krebsforschungszentrum, Heidelberg Hotel Bischofshof am Dom Michael Jensen www.hotel-bischofshof.de | Phone: +49 (0)941 5846 0 Ben Towne Center for Childhood Cancer Research Hotel Münchner Hof Center for Childhood Cancer Research, Seattle www.muenchner-hof.de | Phone: +49 (0)941 5844 0 Carl June Pathology and Laboratory Medicine Online-Registration Perelman School of Medicine at University of Pennsylvania, Philadelphia www.congress-registration.ukr.de Ulrike Köhl Date Institute of Cellular Therapeutics Hannover Medical School, Hannover July 17th - 18th 2019 Megan Levings Conference Fee Faculty of Medicine/Department of Surgery Industry participants incl. social program & dinner 400 € BC Children`s Hospital Research Institute, Vancouver Industry participants excl. social program & dinner 350 € Marcela Maus Regular participation incl. social program & dinner 250 € Cellular Immunotherapy Regular participation excl. social program & dinner 200 € MGH Center for Cancer Research, Charlestown PhD Students incl. social program & dinner 125 € Massimiliano Pagani UKR, UR free of charge (conference dinner € 45,-) Medical Biotechnology and Translational Medicine Registration mandatory prior to the symposium. Instituto Nazionale Genetica Moecolare (INGM), Milano Regensburg Center for Interventional Immunology RCI Shimon Sakaguchi Participants limited to 150. Experimental Immunology First come, fi rst serve. WPI Immunology Frontier Research Center, Osaka University, Osaka Organisation Dolores Schendel University Hospital Regensburg Chief Executive Offi cer and Chief Scientifi c Offi cer Conference Division UK3, Britta Haseneder International RCI symposium Medigene AG, Munich Franz-Josef-Strauß-Allee 11 Hans Stauss Synthetic Immunology and environ- Division of Infection and Immunity 93053 Regensburg, Germany Institute of Immunity and Transplantation, London Phone: +49 (0)941 944-4230 | Fax: +49 (0)941 944-4233 [email protected] ment-adapted redirection of T cells Registration conditions After your successful registration you will receive a payment request concerning your parti- Thon-Dittmer-Palais Regensburg, Germany cipation fee during the next days by email. Once registered your registration is binding. All payments must be made prior to the conference. Participation fees are due upon receipt July 17th - 18th 2019 of payment request without deduction. Please transfer the participation fee amount before the event date. In case of a cancellation the cancellation statement must be in writing. The following processing fees apply: 8-3 working days before the event 50% of participation fee. In case of too late cancellation or absence without written cancellation the entire fee will be charged. A substitute participant may be submitted at any time. ukr.de

Photo and rights: RCI March 2019 Welcome Address Program Program

Dear colleagues, Wednesday, July 17th, 2019 04:00 pm Regulatory T cells in allogeneic SCT Thon-Dittmer-Palais, Haidplatz 8, 93047 Regensburg Matthias Edinger The reprogramming of T cells for tissue-specifi c therapies 09:00 am - 01:00 pm Morning session: 04:30 pm Short talk and the development of environment-smart immune cell Gene immunotherapy: clinical experience N.N. therapies against cancer and autoimmune disorders is 09:00 am Keynote lecture: 04:45 pm Coffee break one of the most promising concepts for the development Next Generation CAR T Cells 05:00 pm - 06:00 pm Evening session: of new treatment strategies in these diseases. Carl June Synthetic biology approaches 10:00 am TCR-T Immunotherapy: Building a Toolbox 05:00 pm Keynote lecture: Rewriting the mammalian During this RCI-conference, we will present and discuss to Enhance Safety and Improve Effi cacy cell ‘source code’ novel synthetic biology approaches and bring together Dolores Schendel Tudor Fulga leading experts from around the world to discuss and 10:30 am From CAR expressing T cells to CAR NK 06:00 pm Social program (registration mandatory): advance the fi eld of synthetic immune cell therapy. cells for cancer retargeting Guided city tour Ulrike Köhl The meeting covers the functional re-programming of 11:00 am Short talk Thursday, July 18th, 2019 immune cells to shape their function in tissues in health N.N. Thon-Dittmer-Palais, Haidplatz 8, 93047 Regensburg and disease, the curative potential of gene-modifi ed 11:15 am Coffee break 09:00 am - 01:00 pm: immune cells and new synthetic approaches to equip 11:35 am Engineering Specifi city and Function Novel functional programs/environment adapted immune cells with extended functional capacities. of T cells Hans Stauss immunity We are looking forward to welcoming you for two exciting 12:05 pm The next wave of CAR T cells for cancer 09:00 am Keynote lecture: Conversion of days in the beautiful city of Regensburg! Marcela Maus effector T cells into regulatory T cells 12:35 pm Synthetic Targeting and Logic-Gated Shimon Sakaguchi On behalf of the board of directors Orthogonal Outputs In the Context of CAR 10:00 am Deciphering the Immune Landscape of Immunotherapy of Cancer Human Cancer Microenvironment Michael Jensen Massimiliano Pagani Philipp Beckhove 01:05 pm Short talk 10:30 am Ontogeny of dendritic cells and Macro- (Director RCI) N.N. phages: From Development to Functions 01:20 pm Lunch & poster session Florent Ginhoux 11:00 am Coffee break 02:30 pm - 04:30 pm Afternoon session: Cell therapy: new concepts 11:30 am Treg cells in non-lymphoid tissues Markus Feuerer 02:30 pm Harnessing the miRNA-epigenetic regu- latory circuitry to enhance CD8+ T cell 12:00 pm Learning pathways antitumor immunity from in vivo lineage tracing of T cells and Luca Gattinoni hematopoietic stem cells Thomas Höfer 03:00 pm CARs, TRUCKs and beyond: the next gen- eration of redirected T cells 12:30 pm Bioinformatics approaches to understand Hinrich Abken the interaction of cancer with the immune 03:30 pm Engineering regulatory T cell specifi city in system and transplantation Benedikt Brors Megan Levings 01:00 pm Farewell & lunch