Within-Arctic Horizontal Gene Transfer As a Driver of Convergent Evolution in Distantly Related 2 Microalgae

bioRxiv preprint doi: https://doi.org/10.1101/2021.07.31.454568; this version posted August 2, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license.

1 Within-Arctic horizontal gene transfer as a driver of convergent evolution in distantly related 2 microalgae

3 Richard G. Dorrell*+1,2, Alan Kuo3*, Zoltan Füssy4, Elisabeth Richardson5,6, Asaf Salamov3, Nikola 4 Zarevski,1,2,7 Nastasia J. Freyria8, Federico M. Ibarbalz1,2,9, Jerry Jenkins3,10, Juan Jose Pierella 5 Karlusich1,2, Andrei Stecca Steindorff3, Robyn E. Edgar8, Lori Handley10, Kathleen Lail3, Anna Lipzen3, 6 Vincent Lombard11, John McFarlane5, Charlotte Nef1,2, Anna M.G. Novák Vanclová1,2, Yi Peng3, Chris 7 Plott10, Marianne Potvin8, Fabio Rocha Jimenez Vieira1,2, Kerrie Barry3, Joel B. Dacks5, Colomban de 8 Vargas2,12, Bernard Henrissat11,13, Eric Pelletier2,14, Jeremy Schmutz3,10, Patrick Wincker2,14, Chris 9 Bowler1,2, Igor V. Grigoriev3,15, and Connie Lovejoy+8

11 1 Institut de Biologie de l'ENS (IBENS), Département de Biologie, École Normale Supérieure, CNRS, 12 INSERM, Université PSL, 75005 Paris, France

13 2CNRS Research Federation for the study of Global Ocean Systems Ecology and Evolution, 14 FR2022/Tara Oceans GOSEE, 3 rue Michel-Ange, 75016 Paris, France

15 3 US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, 1 16 Cyclotron Road, Berkeley, CA 94720, USA

17 4 Charles University, Faculty of Science, Department of Parasitology, BIOCEV, Vestec, Czech Republic

18 5 Division of Infectious Disease, Department of Medicine, University of Alberta and Department of 19 Biological Sciences, University of Alberta

20 6 University of Alberta School of Public Health, 3-300 Edmonton Clinic Health Academy, 11405 - 87 21 Ave Edmonton, AB, T6G 1C9, Canada

22 7 Centre des Recherches Interdisciplinaires, Paris, France

23 8 Département de biologie, Institut de Biologie Intégrative des Systèmes, Université Laval, 1045 24 Avenue de la Médicine, Quebec, QC, G1V 0A6, Canada

25 9 Centro de Investigaciones del Mar y la Atmósfera, CONICET, Universidad de Buenos Aires, 26 C1428EGA Buenos Aires, Argentina

27 10 HudsonAlpha Institute for Biotechnology, 601 Genome Way, Huntsville, AL 35806, USA

28 11 Architecture et Fonction des Macromolécules Biologiques, CNRS, Aix-Marseille Université, 13288 29 Marseille, France

30 12 Sorbonne Université, CNRS, Station Biologique de Roscoff, AD2M, UMR 7144, 29680 31 Roscoff, France

32 13 Department of Biological Sciences, King Abdulaziz University, Jeddah, Saudi Arabia 33 34 14 Génomique Métabolique, Genoscope, Institut de biologie François Jacob, Commissariat à l'Énergie 35 Atomique (CEA), CNRS, Université Évry, Université Paris-Saclay, Évry, France 36

37 15 Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA 94720 38 USA

39 *contributed equally to this study

40 +to whom correspondence should be addressed: [email protected], 41 [email protected]

44 Abstract

45 The Arctic Ocean is being impacted by warming temperatures, increasing freshwater and highly 46 variable ice conditions. The microalgal communities underpinning Arctic marine food webs, once 47 thought to be dominated by diatoms, include a phylogenetically diverse range of small algal 48 species, whose biology remains poorly understood. Here, we present genome sequences of a 49 cryptomonad, a haptophyte, a chrysophyte, and a pelagophyte, isolated from the Arctic water 50 column and ice. Comparing protein family distributions and sequence similarity across a densely- 51 sampled set of algal genomes and transcriptomes, we note striking convergences in the biology of 52 distantly related small Arctic algae, compared to non-Arctic relatives; although this convergence is 53 largely exclusive of Arctic diatoms. Using high-throughput phylogenetic approaches, incorporating 54 environmental sequence data from Tara Oceans, we demonstrate that this convergence was partly 55 explained by horizontal gene transfers (HGT) between Arctic species, in over at least 30 other 56 discrete gene families, and most notably in ice-binding domains (IBD). These Arctic-specific genes 57 have been repeatedly transferred between Arctic algae, and are independent of equivalent HGTs 58 in the Antarctic Southern Ocean. Our data provide insights into the specialized Arctic marine 59 microbiome, and underlines the role of geographically-limited HGT as a driver of environmental 60 adaptation in eukaryotic algae.

61 Keywords: Baffin Bay/ Pikialasorsuaq; pico-phytoplankton; PF11999 domain/ ice-binding proteins; 62 secreted proteins; polar adaptations; environmentally-resolved phylogenetics.

65 Introduction

66 Four global marine biomes have been defined based on temperature, salinity and mixing 67 regimes(Longhurst, 2006). The polar biome is characterized by year-round near freezing 68 temperatures making polar oceans salinity- rather than temperature-stratified (Carmack, 2007). The 69 Arctic Ocean stands apart from the Antarctic Southern Ocean through its greater geographical 70 isolation (Beszczynska-Moller, Woodgate, Lee, Melling, & Karcher, 2011) and having fresher surface 71 waters due to the inflow from large rivers. This added freshwater isolates the upper photic zone from 72 saltier deep waters, and seasonal freezing renders the entire Arctic Basin an ice-influenced 73 ecosystem.

74 The marine Arctic food web is supported by photosynthetic activity, performed by microalgae 75 inhabiting both the water column (phytoplankton) and sea ice (sea-ice algae). These algae are 76 phylogenetically diverse, including green algae, cryptomonads, haptophytes, dinoflagellates and 77 ochrophytes (e.g., diatoms, pelagophytes and chrysophytes) (Fig. 1) (Dorrell et al., 2021a; Li, 78 McLaughlin, Lovejoy, & Carmack, 2009). The lineages that comprise these algae split from one 79 another hundreds of millions of years in the past and have acquired photosynthetic capacity through 80 multiple chloroplast endosymbiotic events (Dorrell et al., 2021a; Strassert, Irisarri, Williams, & Burki, 81 2021).

82 Arctic-isolated algae show distinct physiological properties, in particular having viable growth 83 temperatures that are far below those of relatives isolated from lower latitudes (Fig. 1- Figure 84 Supplement 1) (Lovejoy et al., 2007). Different Arctic microalgae proliferate in different niches, from 85 cold open water to ice, including microhabitats with variable salinity during ice formation and 86 melting. During the early spring, high concentrations of nutrients in the Arctic Ocean surface 87 facilitate diatom growth (Leu et al., 2015; Li et al., 2009; Lovejoy et al., 2007). However, from the late 88 spring onwards, freshwater from river runoff and ice melt enforce vertical stratification of the Arctic 89 Ocean, keeping inorganic nutrients below the photic zone. Low nutrient conditions favour smaller 90 species with high surface-to-volume ratios and photo-mixotrophic life strategies (Bock et al., 2021; 91 Jeong et al., 2021; Lie et al., 2018; McKie-Krisberg & Sanders, 2014). Ice-dwelling species are also 92 exposed to salinity fluctuations, nutrient pulses and depletion, and have the ability to maintain viable 93 cells during ice-free periods. Defining the genetic adaptations underpinning these small algal species 94 is crucial as a baseline to understand their response to anthropogenic global change (Notz & Stroeve, 95 2016).

96 A small number of algal genomes has been previously assembled from polar biomes, including the 97 Antarctic diatom Fragilariopsis cylindrus, the Antarctic chlorophytes Chlamydomonas sp. ICE-L and 98 sp. UWO241, and the dinoflagellate Polarella glacialis (Mock et al., 2017; Stephens et al., 2020; X. 99 Zhang, Cvetkovska, Morgan-Kiss, Hüner, & Smith, 2021; Z. Zhang et al., 2020). These libraries have 100 yielded insights into the adaptation of algae to high latitudes, including genes encoding ice-binding 101 proteins (IBPs) that facilitate tolerance to freezing conditions, and that have been acquired via 102 horizontal transfers from cold-adapted bacteria (Mock et al., 2017; Raymond, 2011; Raymond & Kim, 103 2012; X. Zhang et al., 2021; Z. Zhang et al., 2020). We extend these insights by sequencing the 104 genomes of four distantly related microalgae isolated from the Pikialasorsuaq/ Northwater Polynyna 105 of the Arctic Ocean (Eegeesiak, Aariak, & Kleist, 2017). Comparing these libraries to sequenced algal 106 genomes (Grigoriev et al., 2021) and transcriptomes from the Marine Microbial Eukaryote

107 Transcriptome Sequencing Project (MMETSP) (Keeling et al., 2014), we reveal remarkable 108 convergence in the coding content of these and other distantly related small Arctic algae. We further 109 demonstrate, using genome-wide phylogenetic approaches (Dorrell et al., 2021a; Stiller et al., 2014) 110 and environmental sequence data including Tara Oceans (Carradec et al., 2018; Ibarbalz et al., 2019; 111 Pesant et al., 2015), that this is partly driven by horizontal gene transfers (HGT) between Arctic algal 112 species. Our data reveal innovations underpinning an Arctic algal “metapan-genome”; and reposition 113 our understanding of HGT as an effector of environmental adaptation that may even be restricted by 114 geographic boundaries.

115 Results

116 New genome sequences from Arctic-isolated algae

117 To improve our understanding of Arctic algal evolution and adaptive diversity, genomes were 118 sequenced from four species isolated from latitudes > 75° N. The four species are distantly related to 119 each other (Fig. 1): Baffinella sp. CCMP2293, a cryptomonad, and Pavlovales sp. CCMP2436, a 120 haptophyte, from pelagic environments; Ochromonas sp. CCMP2298, a chrysophyte from sea ice; 121 and a novel pelagophyte species CCMP2097 from a brine pocket on the sea ice surface (Table S1, 122 sheet 1) (Hamilton, Lovejoy, Galand, & Ingram, 2008; Terrado, Monier, Edgar, & Lovejoy, 2015). All 123 four species have been demonstrated to grow optimally at low temperatures (<6 °C; Fig. 1- Figure 124 Supplement 1) (Keeling et al., 2014; Lovejoy et al., 2007; Terrado et al., 2015).

125 Phylogenetic contexts of the sequenced Arctic algae were assessed through a concatenated tree of 126 250 conserved single-copy nuclear genes (39,504 aa) for 391 taxa from across the eukaryotic tree of 127 life (Fig. 1; Table S1, Sheets 2-3) (Burki et al., 2016), alongside densely sampled single-gene trees of 128 nuclear 18S and plastid 16S rDNA (Fig. 1- Figure Supplements 2-5; Table S1, Sheets 4-7). Baffinella sp. 129 CCMP2293 was resolved in an 18S analysis to a well-supported clade containing the conspecific 130 Arctic cryptomonad Baffinella frigidus CCMP2045 (Fig. 1- Figure Supplement 2; (Daugbjerg, Norlin, & 131 Lovejoy, 2018)), whereas the novel pelagophyte CCMP2097 was placed in 18S and 16S analyses near 132 Arctic environmental isolates and members of the genus Ankylochrysis (Fig. 1- Figure Supplement 3) 133 (Han et al., 2018); both were distant to other polar species with sequenced genomes or 134 transcriptomes (Fig. 1). Pavlovales sp. CCMP2436 was placed, in all three analyses, at the base of the 135 clade that includes the otherwise non-polar genus Diacronema (Bendif et al., 2011) (Fig. 1- Figure 136 Supplement 4), while Ochromonas sp. CCMP2298 was found in the 18S and multigene analysis to be 137 most closely related to the temperate species Ochromonas sp. CCMP1393 (Fig. 1; Fig. 1- Figure 138 Supplement 5) (Keeling et al., 2014; Lie et al., 2018).

139 Next, geographical distributions were calculated for 18S (V4 and V9 variable regions) and 16S (V4V5 140 regions) ribotypes from the Tara Oceans (including Polar Circle) Expeditions that were 141 phylogenetically reconciled to each sequenced Arctic isolate (de Vargas et al., 2015; Ibarbalz et al., 142 2019; Sunagawa et al., 2015) (Fig. 2; Table S1, sheets 8-11). All four species were most frequently 143 identified in surface water samples and 3 or 5 to 20 μm size fractions (Fig. 2- Figure Supplement 1). 144 Baffinella sp. CCMP2293 and the novel pelagophyte CCMP2097 were relatively abundant, with > 145 10,000 total mapped ribotypes across all samples and size fractions, the majority of which were from 146 Arctic Ocean stations (Fig. 2; Fig. 2- Figure Supplement 2 panels A, B). Pavlovales sp. CCMP2436 and 147 Ochromonas sp. CCMP2298 were much rarer, with Ochromonas sp. CCMP2298 only detected in 16S 148 V4-V5 ribotypes; and both were exclusively located in the Arctic (Fig. 2; Fig. 2- Figure Supplement 2

149 panels C, D). The relative abundances of all four species were negatively associated with temperature 150 (Spearman f-test, P < 0.05) specifically in Northern hemisphere stations (Fig. 2- Figure Supplement 3; 151 Table S1, sheet 12), suggesting cold-adaptation and predominant restriction to the Arctic. Similar 152 results were obtained for 0.8-2000 μm size fraction samples, albeit with some presence of relatives 153 of Baffinella sp. CCMP2293 and the novel pelagophyte CCMP2097 outside of the Arctic (Fig. 2- Figure 154 Supplement 2 panels A, B).

155 Arctic algae possess expanded genomes with distinct composition

156 Possible genomic trends underpinning the biology of Arctic algal species were inferred across a 157 dataset of 24 sequenced algal genomes (Grigoriev et al., 2021) and 296 MMETSP transcriptomes 158 (Keeling et al., 2014) from eight groups (chlorophytes, chrysophyte-related species, cryptomonads, 159 diatoms, dictyochophytes, dinoflagellates, haptophytes and pelagophytes) with at least one 160 sequenced Arctic species, henceforth referred to as the “pan-algal dataset” (Table S1, sheet 2). The 161 Arctic algal genomes were typically larger than sequenced non-Arctic relatives: most dramatically, 162 the Baffinella sp. CCMP2293 genome (534.5 Mbp total content) is 6.13 times that of the non-Arctic 163 cryptomonad Guillardia theta (87.2 Mbp; Table S2, sheet 1) (Curtis et al., 2012), although more 164 moderate expansions (between 1.17 and 2.11 times the size of nearest sequenced relatives in the 165 dataset) were observed for other Arctic algae. A broader analysis of the pan-algal dataset (Table S2, 166 sheets 2, 3) revealed higher ratios of genes to PFAM protein domains (i.e., suggesting an expansion in 167 genes without known PFAM functions), in Arctic than non-polar sequence libraries. This enrichment 168 was statistically significant (one-way ANOVA, P < 0.05) for Arctic cryptomonads and chrysophytes 169 compared to non-Arctic relatives (Table S2, sheet 3).

170 The Arctic species within the pan-algal dataset encoded greater proportions of small hydrophobic 171 residues (alanine, glycine, and valine, one-way ANOVA, P= 0.013), and smaller proportions of charged 172 residues (aspartate, glutamate, lysine and arginine, P= 0.032) than non-Arctic species (Table S2, 173 sheets 4, 5). The enrichment in small hydrophobic residues was further found specifically in Arctic 174 chrysophytes and pelagophytes compared to non-polar relatives (P < 0.05; Table S2, sheet 5). 175 Genome expansions have previously been identified in psychrophilic prokaryotes (Royo-Llonch et al., 176 2020)and eukaryotes (X. Zhang et al., 2021; Z. Zhang et al., 2020); as have expansions in hydrophobic 177 residues in cold-adapted bacteria (Metpally & Reddy, 2009) and freshwater eukaryotic algae (Nelson 178 et al., 2021)suggesting possible adaptive features to the cold, fresher Arctic waters.

179 Convergence in protein domain content between distantly related small Arctic algae

180 Next, we considered the global similarity of Arctic algal genomes and transcriptomes to one another, 181 considering PFAM domain distributions as a proxy (Fig. 3;(Mistry et al., 2020)). Phylogenetically- 182 aware principal component analyses (phylPCA) of genomes (Fig. 3- Figure Supplement 1i) and 183 transcriptomes (Fig. 3- Figure Supplement 1ii) revealed clusters of some Arctic species (e.g., 184 Pavlovales sp. CCMP2436, the novel pelagophyte CCMP2097, and Ochromonas sp. CCMP2298), albeit 185 with others (e.g., Baffinella sp. CCMP2293) forming outliers. To determine if Arctic species have 186 converged on similar PFAM contents, pairwise Bray-Curtis indices were calculated between the 187 PFAM distributions across the pan-algal dataset, considering genome and transcriptome libraries 188 separately (Fig. 3- Figure Supplement 2; Table S2, sheets 6, 8-10) (Anderson et al., 2016; Horn et al., 189 2016; Nelson et al., 2021).To avoid artifacts caused by differences in phylogenetic proximity, species 190 from the same taxonomic group were excluded (Fig. 3- Figure Supplement 2) prior to calculating

191 mean Bray-Curtis values between pairs of libraries from different habitats (either: Arctic, Antarctic/ 192 Southern Ocean, or “Other” for non-polar species).

193 Pairs of Arctic species showed greater mean similarity in PFAM content (genome mean 0.663; 194 transcriptome mean 0.596) than pairs of Arctic and non-polar species (genome mean 0.541; 195 transcriptome mean 0.556); or pairs of non-polar species did to one another (genome mean 0.551; 196 transcriptome mean 0.512; Fig. 3). The mean Bray-Curtis value observed between Arctic species pairs 197 was significantly greater than that observed between pairs of Arctic and non-Arctic species (one-way 198 ANOVA, genomes P = 6 x 10-05; transcriptomes P = 0.002); and between pairs of non-Arctic species 199 (genomes P = 0.01; transcriptomes P = 0; Fig. 3). Greater similarity was noted between pairs of Arctic 200 species than between Arctic and Antarctic species (e.g., Fragilariopsis cylindrus) (Mock et al., 2017) in 201 both genomes (mean = 0.527, P = 0.0047) and transcriptomes data (mean 0.569; P = 0.049), 202 indicating that this convergence is specific to the Arctic Ocean (Fig. 3). Statistically significant 203 convergences were also observed between Arctic genomes considering the BUSCO-adjusted number 204 of PFAMs shared between each library, suggesting it was independent of the completeness of Arctic 205 and non-Arctic libraries in the pan-algal dataset (Fig. 3- Figure Supplement 3A); and from the 206 Spearman rank index of PFAMs in the transcriptomes dataset (34) (Choi & Kim, 2007), indicating that 207 this was not due solely to expansions in Arctic algal PFAM contents (Fig. 3- Figure Supplement 3B).

208 Convergences involved diverse species, with Pavlovales sp. CCMP2436 having greater convergence to 209 the novel pelagophyte CCMP2097; and Arctic chlorophytes and dinoflagellates likewise having 210 greater convergence to one another than to non-Arctic equivalents, for all metrics tested (Fig. 3- 211 Figure Supplement 4; Table S2, Sheet 10). Exclusion of diatoms from the PFAM dataset indeed 212 strengthened the separation between Arctic-Arctic species pairs and other biogeographical 213 categories of species pairs in Bray-Curtis, BUSCO-corrected Bray-Curtis, and Spearman correlation 214 calculations (Fig. 3- Figure Supplement 5; Table S2, sheet 10). This may point to separate trends in 215 PFAM content between Arctic diatoms, and smaller size fraction picophytoplankton in the Arctic.

216 Arctic-associated PFAMs are spread by within-Arctic horizontal gene transfer

217 Next, we determined which PFAMs were principally responsible for the convergence in PFAM 218 content amongst Arctic algae (Fig. 4). We considered both occurrence in Arctic species (Table S2, 219 sheet 6) and expansions or contractions in copy number in Arctic species compared to their closest 220 non-Arctic relatives (Table S3, sheet 1) (X. Zhang et al., 2021), performed through a phylogenetically- 221 calibrated CAFE (Computational Analysis of gene Family Evolution) across the pan-algal dataset (De 222 Bie, Cristianini, Demuth, & Hahn, 2006). Multiple PFAM domains were more frequently detected, or 223 more frequently underwent expansions (two-tailed chi-squared P < 10-05) in Arctic species within the 224 dataset (Fig. 4; Table S3, sheet 2), with exemplar distributions of eight such PFAMs shown in Fig. 4- 225 Figure Supplement 1.

226 The most highly Arctic-associated PFAM domain, both considering presence and expansion 227 frequencies (P < 10-25), was PF11999 (Figs. 4, 5), encoding ice-binding domains (Raymond, 2011; 228 Raymond & Kim, 2012; Vance, Bayer-Giraldi, Davies, & Mangiagalli, 2019). Ice-binding domains, 229 which typically complex with water through six threonine-rich domains within a larger hydrophobic 230 manifold, play key roles in cryotolerance, variously allowing cold-adapted species to avoid osmolysis 231 during freezing transitions within the cell, or allowing membrane surface transporters to be kept 232 open, or even adhesion of cells to the ice surface if secreted (Raymond, 2011; Raymond & Kim, 2012;

233 Vance et al., 2019). Ice-binding domains were accordingly detected in the overwhelming majority of 234 the Arctic species in the dataset, with the greatest number (100 annotated in the transcriptome; 40 235 in the genome) in Pavlovales sp. CCMP2436 (Fig. 4- Figure Supplement 1). A broader analysis of 236 environmental sequences containing a predicted PF11999 domain from Tara Oceans (Carradec et al., 237 2018) confirmed a strong polar signature (Fig. 5- Figure Supplement 1; Table S3, sheet 3). Nearly all 238 of the individual Tara Oceans genes showed either exclusively Arctic or exclusively Antarctic 239 distributions, with only thirty (out of 1,607 total sequences) found at intermediate latitudes, and only 240 four distributed in both poles (Table S3, sheets 3, 6).

241 To investigate the evolutionary history underpinning the differential enrichment of ice-binding 242 domains in Arctic species, we constructed a 4,862 branch tree of ice-binding domains, from all 4 243 query genomes, all 317 genomes and transcriptomes in the pan-algal dataset, all of UniRef (Suzek, 244 Huang, McGarvey, Mazumder, & Wu, 2007), and all sequences from Tara Oceans; labelling each 245 sequence by the phylogenetic origin of the underlying species and, where known, the geographical 246 location (Fig. 5; Table S3, sheets 3, 7). The tree topology of ice-binding sequences did not match the 247 underlying species phylogenies, but was separated in predominantly Arctic- and Antarctic-clades; 248 consistent with within-ocean HGT (Fig. 5). “Arctic clade A” contains the dinoflagellate Heterocapsa 249 arctica; followed by the distantly related dinoflagellate Polarella glacialis (Dorrell et al., 2017; 250 Stephens et al., 2020). Of note, P. glacialis contains both Arctic (CCMP2088) and Antarctic 251 (CCMP1383) isolated strains, which resolve as sister-groups (with multiple direct orthologues, 252 (Stephens et al., 2020)). The position of both strains within an otherwise Arctic-isolated clade within 253 the tree thus implies that P. glacialis was ancestrally present in the Arctic and that CCMP1383 254 subsequently arrived in the Antarctic (Stephens et al., 2020). Arctic clade A further contains, in 255 probable order of acquisition: the novel pelagophyte CCMP2097; Pavlovales sp. CCMP2436; 256 Baffinella sp. CCMP2293; and finally dinoflagellates within the Scrippsiella hangoei/ Peridinium 257 aciculiferum species complex, which are distant from H. arctica or P. glacialis and have freshwater 258 Arctic distributions (Craveiro, Daugbjerg, Moestrup, & Calado, 2017; Dorrell et al., 2017; Keeling et 259 al., 2014). Similarly, Clade B contained putative transfers between Ochromonas sp. CCMP2298, the 260 boreal freshwater non-photosynthetic chrysophyte Pedospumella encystans (Beisser et al., 2017; 261 Dorrell et al., 2019; Grossmann, Bock, Schweikert, & Boenigk, 2016) and an Arctic dictyochophyte, 262 CCMP2098 (Terrado et al., 2015); Clade C consisted of transfers between the Arctic dictochophyyte 263 CCMP2098 and the chlorophyte Pyramimonas sp. CCMP2087 (Lovejoy et al., 2007); and Clade D 264 consisted of HGT between Pavlovales sp. CCMP2436, the Arctic chlorophyte Micromonas sp. 265 CCMP2099, and multiple Arctic Tara Oceans sequences (clade D) (Lovejoy et al., 2007; McKie- 266 Krisberg & Sanders, 2014). Finally, two Antarctic-specific clades indicate parallel horizontal transfers 267 of ice-binding proteins within Antarctic algae, specifically between the haptophyte Phaeocystis 268 antarctica and multiple diatoms including Fragilariopsis cylindrus) (Gast, Moran, Dennett, & Caron, 269 2007; Keeling et al., 2014; Mock et al., 2017), with Antarctic bacteria as a probable outgroup 270 (Brinkmeyer et al., 2003; Muñoz-Villagrán et al., 2018) (clade 1), and between the cryptomonad 271 Geminigera cryophila, the chlorophyte Mantoniella antarctica and the Antarctic fungi Glaciozyma 272 antarctica and Leucosporidium sp. AY30 (Lovejoy et al., 2007; Turchetti et al., 2011) (clade 2).

273 The topology of the IBD tree was corroborated by an internal BLAST search of the alignment to itself 274 (Table S3, sheets 3, 8, 9), which demonstrated that (excluding hits to congeneric species, and to 275 environmental sequence isolates) Antarctic and Arctic species typically retrieved best-scoring hits to 276 other algae from the same oceanic region (Fig. 5- Figure Supplement 2). These included enrichments

277 in reciprocal hits between Heterocapsa arctica, Baffinella sp. CCMP2293 and Pavlovales sp. 278 CCMP2436 (Arctic clade A); Pedospumella encystans, Ochromonas sp. CCMP2298 and the 279 dictyochophyte CCMP2098 (Arctic clade B); and Mantoniella antarctica and Geminigera cryophila 280 (Antarctic clade 2).

281 Several additional PFAMs were significantly enriched in Arctic species (Fig. 4; Fig. 4- Figure 282 Supplement 1). These included PF03988/ DUF347, which is likely to encode an efflux transporter 283 implicated in metal stress responses in the diatom Thalassiosira pseudonana (Davis, Hildebrand, & 284 Palenik, 2006) and the boreal actinomycete Frankia (Furnholm & Tisa, 2014), and previously shown 285 to be expanded in Scrippsiella hangoei (Stephens, Ragan, Bhattacharya, & Chan, 2018). A second 286 example was PF03831 (PhnA, YjdM), which functions as an uptake protein or inducer involved in 287 alkyl-phosphonate metabolism (Chetouani, Glaser, & Kunst, 2001; Kulakova et al., 2001), and was 288 previously shown to be expanded in bacteria from the phycosphere of Antarctic seaweeds (Cid et al., 289 2018). Phylogenetically and biogeographically-resolved analyses of each PFAM, using Tara Oceans- 290 enriched datasets (Table S3, sheets 4-7), revealed probable HGTs between Pavlovales sp. CCMP2436 291 and Scrippsiella hangoei in the PF03988/ DUF347 tree (Fig. 5- Figure Supplement 3); and between the 292 novel pelagophyte CCMP2097 and the Arctic dictyochophyte CCMP2098 in the PF03831/ PhnA 293 domain tree (Fig. 5- Figure Supplement 4).

294 Widespread occurrence of within-Arctic HGT across Arctic algal genomes

295 Next, we investigated the probable frequency of within-Arctic HGT across all available genomes of 296 Arctic algae (Fig. 6). We adapted a protocol from previous studies based on LASTal analysis (Kiełbasa, 297 Wan, Sato, Horton, & Frith, 2011) and linear regression (Dorrell et al., 2019; Metpally & Reddy, 2009; 298 Stiller et al., 2014) (Fig. 6- Figure Supplement 1; Table S4, sheet 2). This involved searching two 299 genomes from a given algal group, one Arctic and the other non-Arctic (a “comparative pair”) against 300 a mixed library of Arctic and non-Arctic genomes and transcriptomes from another algal group (Fig. 301 6- Figure Supplement 1A). As both members of the comparative pair are of equivalent phylogenetic 302 distance to all species within the reference library, the number of LAST best hits obtained from the 303 Arctic and non-Arctic queries for each reference should be correlated, with deviations indicating 304 convergences (e.g., HGT with the query species) (Fig. 6- Figure Supplement 1B).

305 Deviations for multiple comparative pairs of Arctic and non-Arctic species were calculated for each 306 species in the pan-algal dataset (Fig. 6). The five species that showed the greatest positive deviations 307 in favour of Arctic queries (mean residual > 40, median residual > 30) were themselves small Arctic 308 algae (the dictyochophyte CCMP2098, Baffinella sp. CCMP2293, Pyramimonas sp. CCMP2087, the 309 pelagophyte CCMP2097, and Ochromonas sp. CCMP2298; Fig. 6). A further five Arctic species 310 showed smaller but significant (chi=squared P < 0.05) enrichments in Arctic best hits, of which only 311 one (Entomoneis sp.) was a diatom; whereas non-Arctic (including Antarctic) algae within the 312 reference dataset showed smaller deviations (Fig. 6; Table S4, sheet 3).

313 To explicitly recover additional within-Arctic HGTs, we used genes from each sequenced Arctic 314 genome that produced LAST best hits involving other Arctic algal species, as seed proteins for the 315 generation of manually curated trees (Table S4, sheets 4; Fig. 6- Figure Supplement 2). Each tree was 316 enriched with the best homologues of the query sequence from all 317 algal genomes and 317 transcriptomes in the pan-algal dataset, a further 82 reference prokaryotic and eukaryotic genomes 318 sampled for taxonomic representation and the inclusion of polar isolated species, and from a

319 previously assembled dataset of 151 combined genome and transcriptome libraries covering the 320 entire tree of life; i.e., up to 559 total homologues (Table S4, sheet 5) (Dorrell et al., 2019; Dorrell et 321 al., 2021a).

322 Following manual curation (Table S4, sheets 6-8), 34 gene clusters were identified that supported 323 within-Arctic HGTs (RAxML threshold bootstrap support 50%; Fig. 6- Figure Supplement 3; Table S4, 324 sheet 9), including a well-supported ice-binding protein clade probably corresponding to “Arctic 325 clade A” in the global IBD phylogeny (Fig. 4). Although a diverse range of Arctic species were 326 detected in the within-Arctic HGT clades, including all four query genomes, the dictyochophyte 327 CCMP2098, Pyramimonas sp. CCMP2087 and multiple Arctic dinoflagellates (Heterocapsa, 328 Scrippsiella, Peridinium sp.), not one tree resolved HGTs between the four query species and Arctic 329 diatoms (Table S4, sheet 9).

330 Several of the genes inferred to have been horizontally transferred between Arctic algae correspond 331 to proteins which may carry out Arctic-adaptive functions (Table S4, sheet 9). These include an 332 alcohol dehydrogenase and a CCCH Zn-finger PFAM domain shared between Baffinella sp. 333 CCMP2293, Pavlovales sp. CCMP2436 and the novel pelagophyte CCMP2097, which are implicated in 334 cold and salinity stress responses in Arabidopsis (Song, Liu, & Ma, 2019; Y. Wang et al., 2017); and a 335 tellurite resistance protein, which was shared between Baffinella sp. CCMP2293 and Ochromonas sp. 336 CCMP2298 and has been previously detected in polar bacteria (Muñoz-Villagrán et al., 2018). The 337 within-Arctic HGT genes were significantly enriched (chi-squared P < 10-05) in signal peptides, 338 consistent with endomembrane or secretory localisations, compared to other genes in the query 339 genomes (Table 1; Fig. 6- Figure Supplement 4; Table S4, sheet 9); as has been noted in other meta- 340 analyses of HGT in non-Arctic eukaryotic microbes (Dorrell et al., 2021a; Eme, Gentekaki, Curtis, 341 Archibald, & Roger, 2017; Irwin, Pittis, Richards, & Keeling, 2021). Finally, considering homologues in 342 Tara Oceans data, five gene families were identified in which all Tara Oceans genes phylogenetically 343 reconciled to the within-Arctic HGT clade had exclusively Arctic distributions, and a further seven in 344 which a majority of the phylogenetically reconciled Tara Oceans unigenes were exclusively Arctic 345 (Fig. 6- Figure Supplement 5; Table S4, sheets 10-11); confirming their probable Arctic-specific 346 functions.

347 Discussion

348 We have harnessed newly sequenced genomes alongside a densely sampled dataset of genomes and 349 transcriptomes, as well as environmental data from Tara Oceans to unveil evolutionary trends in 350 algae isolated from the Arctic Ocean. Our data suggests convergence in the coding content of diverse 351 small Arctic algae, linked to the presence of Arctic-specific genes, although with the exclusion of 352 Arctic diatoms. We further show that within-Arctic HGT, exemplified by genes coding for ice-binding 353 domains, is an important component of this convergent evolution. The overall results position 354 within-ocean HGT as a mechanism of environmental adaptation, which may occur via biotic 355 interactions characteristic of Arctic species such as photo-mixotrophy (McKie-Krisberg & Sanders, 356 2014; Søgaard et al., 2021) and viral infection (Irwin et al., 2021; Nelson et al., 2021); or even the 357 direct exchange of genetic material through the Arctic water column or sea ice (Raymond, 2011; 358 Raymond & Kim, 2012).

359 It remains to be determined whether within-Arctic convergences in sequenced species, which were 360 predominantly sampled from Baffin Bay, extend to other regions within the Arctic Ocean, and algal

361 groups. Deeper sequencing of Arctic species, either from cultured isolates, or from Arctic-specific 362 Metagenome Assembled Genomes (Cao et al., 2020; Vorobev et al., 2020), will be instrumental in 363 determining their broader genomic diversity. In particular, deeper sequencing of Arctic diatoms will 364 be instrumental to understanding their different coding contents to small algal species, which may 365 underpin their different relative seasonal niches in the Arctic (Joli, Monier, Logares, & Lovejoy, 2017; 366 Li et al., 2009), and particularly considering the large numbers of diatom-specific HGT events 367 visualised in previous phylogenomic studies of pan-algal HGTs (Dorrell et al., 2021a; Vancaester, 368 Depuydt, Osuna-Cruz, & Vandepoele, 2020). Moreover, the regulation and functions of individual 369 genes inferred to have undergone within-Arctic HGT await characterisation, e.g., using comparative 370 transcriptomic approaches (Liang, Koester, Liefer, Irwin, & Finkel, 2019; Mock et al., 2017; Terrado et 371 al., 2015) or through the expression and characterisation of candidate genes in transformable model 372 algae. Finally, it remains to be determined to what extent discrete protein functional architectures 373 have independently and convergently evolved in Arctic-, Antarctic-, and other cryophilic and ice- 374 adapted (e.g., montane) algal species, as in the case of ice-binding domains, which may have 375 independently originated multiple times within the tree of life (Stewart et al., 2021; Vance et al., 376 2019). Further functional, phylogenetic and environmental investigation of the Arctic algal metapan- 377 genome may unveil effectors of the fitness or decline of small Arctic algae in a warming and 378 freshening ocean environment (Li et al., 2009); and facilitate our understanding of the environmental 379 fragility and future ecology of this important ocean biome.

380 Materials and Methods

381 Cultures and nucleic acid isolation

382 The algae were all isolated from Northern Baffin Bay within the Pikialasorsuaq/ Northwater Polynya 383 (Eegeesiak et al., 2017)in June 1998 using a serial selection-dilution technique until a single species 384 was isolated, and have been maintained as mono-algal cultures in L medium without Si at a salinity of 385 30 and ca. 4 °C and under continuous illumination since (Terrado et al., 2015). Prior to growing the 386 sub-cultures used for DNA sequencing, the culture was transferred to L medium with added 387 antibiotics (Terrado et al., 2015) to minimize bacterial contamination, which was assessed via light 388 microscopy.

389 Nucleic acids were harvested from the batch culture in late exponential phase by centrifugation at 390 3000 g for 30 minutes at 4 °C. The supernatant was discarded and pellets were frozen in liquid 391 nitrogen and stored at -80 °C until nucleic acid extraction. RNA and DNA was collected for whole 392 genome sequencing following the U.S. Department of Energy Joint Genome Institute (DOE JGI) 393 protocols (Rio et al., 2006).

394 Sequencing

395 Genomes in this study were sequenced on an Illumina platform using a combination of a 400-800 bp 396 Tight Insert library with 1.5 kb, 4 kb, and 8 kb insert Cre-LoxP Recombination (CLR) libraries. For the 397 pelagophyte CCMP2097, Ligation-free paired end (LFPE) libraries were additionally used.

398 For Tight Insert libraries, 2-3 µg of DNA was sheared to 400 bp or 800 bp using a Covaris LE220 pulse 399 focused sonicator (Covaris) and size selected using a Pippin Prep (Sage Science). The fragments were 400 end-repaired, A-tailed and ligated to Illumina compatible adapters (IDT, Inc) using a KAPA-Illumina

401 library creation kit (KAPA biosystems). For CLR libraries, 5-25 µg of DNA was sheared using a Covaris 402 g-TUBE (Covaris) and gel size-selected for 1.5 kb, 4 kb, and 8 kb, respectively. The sheared DNA was 403 end-repaired and ligated with biotinylated adapters containing loxP, circularized via recombination 404 by a Cre excision reaction (NEB), and randomly sheared using a Covaris LE220 (Covaris). For LFPE 405 libraries, 15-25 µg of DNA was sheared using HydroShear (Genomic Solutions) and gel size selected 406 for 4.5 kb and 8 kb, respectively. The sheared DNA was end-repaired, ligated with biotinylated 407 adapters, circularized by Intra-Molecular Hybridization, then digested with T7 Exonuclease and S1 408 Nuclease (Invitrogen).

409 Sheared ligation fragments were end-repaired and A-tailed using the KAPA-Illumina library creation 410 kit (KAPA biosystems) followed by immobilization of mate pair fragments on streptavidin beads 411 (Invitrogen). Illumina compatible adapters (IDT, Inc) were ligated to the mate pair fragments and 412 amplified with 8-12 cycles of PCR (KAPA Biosystems).

413 All four transcriptomes were sequenced using stranded Illumina RNA-Seq protocols. Poly(A)+ RNA 414 was isolated from 10 ug total RNA using a Dynabeads mRNA isolation kit (Invitrogen), repeated twice 415 to remove all residual rRNA contamination; then fragmented using RNA Fragmentation Reagents 416 (Ambion) at 70 °C for 3 min, targeting fragments around 300 bp, and purified using AMPure SPRI 417 beads (Agencourt). Reverse transcription was performed using random hexamer primers (Fermentas) 418 and SuperScript II (Invitrogen), with annealing, elongation and inactivation steps of 65 °C for 5 min, 419 42 °C for 50 min, and 70 °C for 10 min, respectively. Purified cDNA was used for second strand 420 synthesis, with a dNTP mix where dTTP was replaced by dUTP at 16 °C for 2 h. Targeted (300 bp) 421 double stranded cDNA fragments were purified using AMPure SPRI beads; then were blunt-ended, 422 poly A-tailed, and ligated with TruSeq adaptors using Illumina DNA Sample Prep Kit (Illumina), and 423 purified again. Second strand cDNA was removed through dUTP digestion with AmpErase UNG 424 (Applied Biosystems). Digested cDNA was again cleaned up with AMPure SPRI beads, amplified by 10 425 cycles PCR with Illumina TruSeq primers, and finally cleaned again with AMPure SPRI beads.

426 Both genome and transcriptome libraries were quantified using a next-generation sequencing library 427 qPCR kit (KAPA Biosystems) and run on a LightCycler 480 real-time PCR instrument (Roche). The 428 quantified libraries were prepared for sequencing utilizing a TruSeq paired-end cluster kit (v3), and a 429 cBot instrument (Illumina) to generate a clustered flow cell, and sequenced on an Illumina HiSeq2000 430 sequencer using a TruSeq SBS sequencing kit, v3, following a 2x100 or 2x150 indexed run recipe.

431 After sequencing, the genomic fastq files were screened for phix contamination. Reads composed of 432 >95% simple sequence were removed. Illumina reads <50bp after trimming for adapter and quality 433 (q<20) were removed. The remaining Illumina reads were assembled using AllPathsLG (Gnerre et al., 434 2011) parameters: DATA_SUBDIR=data RUN=run SUBDIR=assem1 TARGETS=standard 435 OVERWRITE=True THREADS=6 CLOSE_UNIPATH_GAPS=False). The resulting assembled scaffolds 436 were screened against all bacterial proteins and organelle sequences from GenBank nr (Wheeler et 437 al., 2006) and removed if found to be a contaminant. Illumina transcriptome reads were QC filtered 438 to remove contamination and assembled into consensus sequences using Rnnotator v. 2.5.3 (Martin 439 & Wang, 2011). Each genome was annotated using the JGI Annotation Pipeline, which detects and 440 masks repeats and transposable elements, predicts genes, characterizes each conceptually translated 441 protein with sub-elements such as domains and signal peptides, chooses a best gene model at each 442 locus to provide a filtered working set, clusters the filtered sets into draft gene families, ascribes

443 functional descriptions (such as GO terms and EC numbers), and creates a JGI genome portal in 444 PhycoCosm (https://phycocosm.jgi.doe.gov/) with tools for public access and community-driven 445 curation of the annotation (Grigoriev et al., 2021; Kuo, Bushnell, & Grigoriev, 2014).

446 Residual contamination, including from Arctic bacteria, was eliminated from each genome using a 447 custom pipeline based on phylogenetic assignation of all genes within each contig via BLAST best-hit 448 search against a combined tree of life library, consisting of complete copies of UniRef, JGI genomes, 449 and MMETSP algal transcriptomes (Dorrell et al., 2019; Dorrell et al., 2021a). Only genes assigned to 450 the same contig as at least one gene of inferred vertical origin (Baffinella sp. CCMP2293- 451 cryptomonads; Pavlovales sp. CCMP2436- haptophytes; Ochromonas sp. CCMP2298 and the novel 452 pelagophyte CCMP2097- ochrophytes) were retained (Table S4, Sheet 1). A second round of cleaning 453 was performed by reciprocal tBLASTn/ BLASTx searches of each peptide sequence against the 454 corresponding MMETSP nucleotide transcriptome libraries (Keeling et al., 2014) that had been 455 decontaminated through a previously published pairwise BLAST similarity analysis (Marron et al., 456 2016) (Table S4, Sheet 1). Only gene models that retrieved a reciprocal best hit with bidirectional 457 threshold value 10-05 were retained for downstream analyses. Between 3,056 (Ochromonas sp. 458 CCMP2298) and 11,568 gene models (Pavlovales sp. CCMP2436) were confirmed to be of 459 unambiguously non-contaminant origin for each genome, and retained for analysis of within-Arctic 460 HGT (Table S4, sheet 1). Full details of the decontamination pipeline employed are provided in the 461 linked supporting database https://osf.io/3pmxb/ (Dorrell et al., 2021b)I n the folder "Within-Arctic 462 HGTs".

463 Comparisons of key properties between the assembled genomes, and their closest assembled 464 relatives (accessed January 2018) in cryptomonads, haptophytes, pelagophytes, and chrysophyte- 465 related species (16) are provided in Table S2, Sheets 1-5. Per-gene analyses of the amino acid 466 compositions of each genome and transcriptome included in this study, as defined below, are 467 provided in the linked supporting database https://osf.io/3pmxb/ (Dorrell et al., 2021b) in the folder 468 "Genome quantitative analysis".

469 Multigene phylogeny

470 A pan-algal dataset of 21 genomes, including the four sequenced in this study (accessed January 471 2018) (Grigoriev et al., 2021) and 296 decontaminated MMETSP transcriptomes (Keeling et al., 2014; 472 Marron et al., 2016) was assembled for eight algal groups for which at least one sequenced Arctic 473 genome or transcriptome has been completed: these being chlorophytes, chrysophyte-related 474 species (including synchromophytes, pinguiophytes and eustigmatophytes ( Dorrell et al., 2021a)), 475 cryptomonads, diatoms, dictyochophytes, dinoflagellates, haptophytes and pelagophytes. The 476 isolation sites of each sequenced species, and minimum and maximum recorded viable growth 477 temperatures, were manually confirmed by comparing to the accession records in public culture 478 collections, considering synonymous culture identifiers where present (Gachon et al., 2013; Guiry et 479 al., 2014; Vaulot, Le Gall, Marie, Guillou, & Partensky, 2004), and are provided in Table S1, Sheet 1.

480 Reference sequences from a previously assembled eukaryotic multigene tree (Burki et al., 2016; 481 Strassert et al., 2021)w ere enriched using diamond v0.9.30.131 (Buchfink, Xie, & Huson, 2015) with 482 orthologues from all members of this dataset. To infer phylogenies, single-gene datasets were 483 aligned by MAFFT v7.407 (Katoh, Rozewicki, & Yamada, 2017) using the L-INS-i refinement and a 484 maximum of 1000 iterations, then trimmed by trimAl v1.4 (Capella-Gutiérrez, Silla-Martínez, &

485 Gabaldón, 2009) using the -gt 0.5 setting. ML trees were inferred by IQ-TREE v 1.6.12 (Nguyen, 486 Schmidt, von Haeseler, & Minh, 2015) using the LG+F+G model. Paralogs were manually removed 487 from single-gene datasets, considering their branching and alignment coverage. The concatenated 488 multi-gene alignment was finally trimmed to remove sites with more than 20% gaps with trimAl (-gt 489 0.8) and sites exhibiting the fastest exchange rates with TIGER(-exc 10 -b 10; (Cummins & McInerney, 490 2011)) analogously to the reference multi-gene matrix (Burki et al., 2016). The final ML tree was 491 reconstructed using the Posterior Mean Site Frequency (PMSF) model of IQ-TREE on a LG+F+G guide 492 tree, with the multi-gene matrix treated as a single partition to eliminate small sample LBA bias(H. C. 493 Wang, Susko, & Roger, 2019). Incorporated gene and tree topologies are provided in Table S1, sheets 494 2-3; and single-gene alignments and topologies, and concatenated alignments are provided in the 495 linked supporting database https://osf.io/3pmxb/ (Dorrell et al., 2021b) in the folder "Multigene tree 496 topologies".

497 18S and 16S phylogeny

498 18S rDNA and chloroplast 16S rDNA sequences corresponding to cultured isolates, and uncultured 499 environmental isolates from the Arctic and Antarctic/Southern Oceans were downloaded for four 500 algal groups (cryptomonads; haptophytes; chrysophyte-related taxa, including chrysophytes, 501 synchromophytes, pinguiophytes and eustigmatophytes; and pelagophytes/ dictyochophytes) 502 (Dorrell et al., 2021a), from GenBank nr (March 2020) (59). These were supplemented with 503 orthologues searched for each group from MMETSP nucleotide sequence libraries by BLASTn, using a 504 randomly selected downloaded query from the group considered, and a threshold e-value of 10-05. 505 Homologous sequences were identified by a reciprocal BLASTn search against a complete copy of the 506 Arabidopsis thaliana chloroplast, mitochondria and nuclear genome enriched with the query 507 sequence; only sequences that retrieved the query as the BLAST best hit were retained (Sato, 508 Nakamura, Kaneko, Asamizu, & Tabata, 1999). A complete set of query sequences are provided in 509 Table S1, sheet 4.

510 Retained homologues were aligned using MAFFT (v. 7.407) under the --auto and --adjustdirection 511 settings; and manually edited to remove non-homologous, fragmented and chimeric sequences 512 (Katoh et al., 2017). Curated alignments were trimmed with trimAl under the -gt 0.5 and -gt 0.8 513 settings (Capella-Gutiérrez et al., 2009); and tree topologies were inferred from trimmed alignments 514 using MrBayes v 3.2.1 and RAxML v 8.0 as integrated into the CIPRES web server (Miller et al., 2015; 515 Stamatakis, 2014). MrBayes trees were run with two chains for 600,000 generations with burnin 516 fractions of 0.5, and were manually verified in each case to have reached a final convergence statistic 517 of ≤0.1 prior to calculation of the consensus topology; whereas RAxML trees were run by default for 518 450 bootstrap replicates, with automatic bootstopping applied. Curated alignments, individual and 519 consensus tree topologies are provided in Table S1, sheets 4-7; and in the linked supporting database 520 https://osf.io/3pmxb/ (Dorrell et al., 2021b) in the folder "18S and 16S trees".

521 Tara Oceans calculations

522 Ribotypes corresponding to the 18S rRNA (V4 and V9 variable regions) and 16S rRNA (V4V5 regions) 523 sequences of each species were identified from version 2 (Arctic-inclusive) of Tara Oceans data 524 (Ibarbalz et al., 2019) using the 18S and 16S trees defined above as a guide. Briefly, the complete 18S 525 or 16S sequence of the species in question was searched by BLASTn against all 18S or 16S plastidial 526 sequences previously assigned to the same taxonomic group as the query (Baffinella sp. CCMP2293:

527 cryptomonads; Pavlovales sp. CCMP2436: haptophytes; Ochromonas sp. CCMP2298: chrysophytes; 528 novel pelagophyte CCMP2097: pelagophytes), with threshold e-value 10-05. Matching sequences 529 were then searched against the complete curated 18S or 16S alignments for each group using 530 BLASTn, and only sequences that yielded BLAST best hits against either the query sequence or its 531 immediate sister groups in the 18S or 16S tree topology were retained for subsequent analysis.

532 Retained ribotypes were realigned against the reference library using MAFFT under the --auto 533 setting, manually trimmed to retain only the 18S V4, 18S V9, or 16S V4V5 regions, and finally 534 trimmed with trimAl under the –gt 0.5 setting (Capella-Gutiérrez et al., 2009; Katoh et al., 2017); and 535 trees were calculated from curated alignments using RAxML with automated bootstopping, as 536 defined above(Stamatakis, 2014). Finally, ribotypes that were inferred from the best-scoring RAxML 537 tree topology to be more closely related to the Arctic query species than the nearest cultured non- 538 Arctic reference; and had a minimum 97% nucleotide similarity to the Arctic query species 18S or 16S 539 rDNA sequence as assessed by BLASTn search; were retained for the calculation of absolute and total 540 relative abundances, expressed as the proportion of all 18S V4, 18S V9 or 16S V4V5 ribotypes present 541 in a sample. Curated alignments and tree topologies are provided in Table S1, sheets 8-9; tabulated 542 individual and total read abundances are provided in Table S1, sheets 10-11; and all raw data 543 pertaining to the identification of matching ribotypes by BLAST and phylogeny, and calculation of 544 quantitative abundance trends, are provided in the linked supporting database https://osf.io/3pmxb/ 545 (Dorrell et al., 2021b) in the folder "TARA Oceans calculations".

546 Quantitative analysis of PFAM content

547 PFAM distributions for each algal genome in the pan-algal dataset (both newly and previously 548 sequenced accessions) were reannotated for this study using InterProScan and an updated 549 (December 2020) version of the PFAM database from the constituent fasta files for each genome 550 (Jones et al., 2014; Mistry et al., 2020). PFAM annotation files for each MMETSP transcriptome were 551 manually downloaded from the source accession; and cleaned using a previously defined pipeline 552 which compares the relative BLAST similarity between pairs of nucleotide sequences in each 553 MMETSP library to identify transcripts of potential contaminant origin (Dorrell et al., 2019; Marron et 554 al., 2016). Tabulated PFAM outputs are provided in Table S2, sheet 6; and complete PFAM lists per 555 gene for each decontaminated library are provided in the linked supporting database 556 https://osf.io/3pmxb/ (Dorrell et al., 2021b) in the folder "PFAM Bray-Curtis distributions".

557 Phylogenetically-aware PCA was performed on both genome and transcriptome datasets (Revell & 558 Graham Reynolds, 2012), due to strong taxonomic effects observed using crude phylogeny- 559 independent analyses. Edited versions of the multigene tree topology (Fig. 1) retaining only genome- 560 or transcriptome branches, were generated using MEGA version X as phylogenetic templates (Kumar, 561 Stecher, Li, Knyaz, & Tamura, 2018). Input and output data for PCA are provided for user exploration 562 in Table S2, sheet 7; and in the linked supporting database https://osf.io/3pmxb/ (Dorrell et al., 563 2021b) in the folder "CAFE and phylPCA".

564 Similarity in PFAM content between different algal PFAM libraries were calculated using Bray-Curtis 565 (Anderson et al., 2016; Horn et al., 2016) and Spearman indices (Choi & Kim, 2007; Nelson et al., 566 2021) following previous studies; and the total number concordant PFAMs between each library pair 567 were additionally normalised against the total number of complete (single-copy or duplicated) 568 eukaryotic BUSCOs retrieved in each library (Simão, Waterhouse, Ioannidis, Kriventseva, & Zdobnov,

569 2015). A schematic diagram explaining the methodology used, and the different types of 570 convergence visible using each technique, is provided in Fig. 3- Figure Supplement 2.

571 For Bray-Curtis and Spearman calculations, algae were divided into three functional categories: Arctic 572 (species isolated from > 60°N); Antarctic (species isolated from > 55°S); and all remaining taxa from 573 intermediate latitudes grouped as “Other”. To avoid introducing biases due to comparing taxa of 574 unequal phylogenetic distance, Bray-Curtis and Spearman calculations were only compared between 575 pairs of algal libraries from different taxonomic groups, and to avoid biases due to comparing taxa 576 with highly divergent life-strategies, all freshwater and secondarily non-photosynthetic taxa were 577 removed from the final dataset. These values were then used to calculate mean values, and perform 578 one-way ANOVAs of difference, within and between different groups of algae in the dataset, 579 separated by biogeography into “Arctic”, “Antarctic” and “Other” taxa, as above. Tabulated Bray- 580 Curtis and Spearman outputs are provided in Table S2, sheets 8-12; and all raw data, including 581 alternative format outputs, are provided in the linked supporting database https://osf.io/3pmxb/ 582 (Dorrell et al., 2021b) in the folder "PFAM Bray-Curtis distributions".

583 Identification of Arctic-associated PFAMs

584 PFAMs whose presence or absence were specifically associated with Arctic species were assessed by 585 calculating the frequency with which the PFAM was recovered in Arctic, compared to non-Arctic 586 species (“Antarctic” or “Other”) in the dataset (Table S2, sheet 6). These frequencies were used to 587 calculate a ratio and a chi-squared P-value of enrichment of the PFAM in Arctic species in the dataset 588 with cutoff P-value 10-05. Only PFAMs that were detected in both Arctic genomes and Arctic 589 transcriptomes were considered as possible candidates for enrichment; and “Freshwater” and “Non- 590 Photosynthetic” species were excluded from the dataset to avoid introducing artifacts by comparing 591 species with highly divergent life strategies.

592 To accurately identify expansions and contractions in PFAM content across each species, high- 593 frequency PFAMs (defined as PFAMs for which the maximum frequency minus minimum frequency 594 observed was greater than 100 across the entire dataset) were first fragmented into smaller 595 orthogroups. Briefly, profiles were extracted for each high frequency PFAM using hmmfetch (Potter 596 et al., 2018), and then re-annotated for all libraries using hmmsearch with threshold expect value 10- 597 05. Proteins containing these domains were used to run OrthoFinder v 2.4.1 (Emms & Kelly, 2019) 598 with inflation value 1.3 to avoid over-fragmentation of orthogroups. Orthogroups were filtered 599 (maximum – minimum frequency > 2) to remove uninformative examples, then the presence of 600 PFAM domains (defined as presence in at least 10% of protein space within the orthogroup) were 601 called for each orthogroup. 602 603 Computational Analysis of gene Family Evolution (CAFE) was performed on the composite set of low- 604 frequency PFAMs, and orthogroups decomposed from high-frequency PFAMs, for separate sets of 605 genome- and transcriptome-only libraries, using MEGA-edited versions of the previously generated 606 multigene reference tree, as per the phylPCA analysis above. (Kumar et al., 2018) A single gamma 607 rate for the lambda and error model was assessed from the low-frequency PFAM dataset across the 608 entire phylogenetic tree. The CAFE outputs obtained were used to calculate enrichment ratios and P- 609 values for “expansions”, defined as signed positive CAFE scores, and “contractions”, defined as 610 signed negative CAFE scores for Arctic species within the dataset, using methodology as defined

611 above. Summarised CAFE outputs and P-values are provided in Table S3, sheets 1-2; and all raw data, 612 including the prior decomposition of PFAMs into orthogroups, are provided in the linked supporting 613 database https://osf.io/3pmxb/ (Dorrell et al., 2021b) in the folder “CAFE and phylPCA”. 614 615 Environmentally supported phylogenies of Arctic-associated PFAMs 616 617 The environmental distributions of sequences containing three PFAMs (PF03831, PF03988, and 618 PF11999) whose presence was significantly associated with Arctic species in the enrichment analysis 619 above were investigated in meta-transcriptome and meta-genome sequence data from the Tara 620 Oceans Expedition, inclusive of sequences from the Arctic Ocean (Carradec et al., 2018; Ibarbalz et 621 al., 2019). Sequences containing each PFAM were extracted using hmmer with gathering threshold 622 option (Potter et al., 2018); and were classified into four categories based on the sum of all relative 623 abundances (normalised against the total number of meta-T or meta-G unigenes sequenced from the 624 sample) across all stations and size/depth fractions. These were : “Arctic” sequences (> 70% summed 625 relative abundances contained in stations of > 60 °N); “Antarctic” sequences (> 70% summed relative 626 abundances contained in stations of > 55°S); “Bipolar” sequences, (> 70% summed relative 627 abundances contained in stations of > 60°N or > 55°S, including >20% each in stations > 60°N and 628 stations > 55°S); and “Other” (< 70% summed relative abundances contained in stations of > 60°N 629 and > 55°S). 630 631 The Tara Oceans sequences were aligned against all sequences containing the PFAM concerned from 632 all algal genomes and transcriptomes considered within this study; and all sequences containing the 633 PFAM in UniRef (downloaded March 2020) (Suzek et al., 2007); using mafft under the --auto setting, 634 followed by a more stringent round of alignment using --gap_open_penalty 12, -- 635 gap_extension_penalty 3 and --maxiteration 2 settings to remove poorly aligned sequences (Katoh 636 et al., 2017). Cultured sequence accessions were manually labelled with “Arctic” and “Antarctic” 637 provenance considering the isolation site of the species, where recorded (Guiry et al., 2014). 638 Alignments were manually trimmed after each step, and subsequently trimmed with TrimAl using the 639 –gt 0.5 setting (Capella-Gutiérrez et al., 2009); and finally used to infer best-scoring trees with RAxML 640 using the PROTGAMMAGTR, PROTGAMMAJTT and PROTGAMMAWAG substitution matrices 641 (Stamatakis, 2014). Environmental sequence calculations, and individual and consensus topologies 642 for each tree are provided in Table S3, sheets 3-7; and in the linked supporting database 643 https://osf.io/3pmxb/ (Dorrell et al., 2021b) in the folder “Environmental PFAM calculations”. 644 645 Global identification of within-Arctic HGTs 646 647 Global biases in algal genome or transcriptome composition, which may reveal underlying HGT 648 events, were inferred using a linear regression pipeline adapted from previous studies (Dorrell et al., 649 2021a; Stiller et al., 2014)(Fig. 6- Figure Supplement 1). To avoid incorporating biological 650 contaminants into these analyses, all four Arctic genomes were initially refined to a “best 651 confidence” set of genes, as described above, consisting of genes present on an assembled contig 652 with at least one gene of clear vertical origin (Baffinella sp. CCMP2293 : cryptomonads; Pavlovales 653 sp. CCMP2436 : haptophytes; Ochromonas sp. CCMP2298 : chrysophytes and novel pelagophyte 654 CCMP2097 : pelagophytes) based on BLASTp best-hit analysis of a combined library from across the 655 tree of life as defined below (Dorrell et al., 2021a); and presence of a corresponding transcript in

656 decontaminated MMETSP transcriptome assemblies for the species, inferred by reciprocal BLASTp 657 best-hit searches (Keeling et al., 2014). 658 659 Next, a comparative pair of query genomes from a specific algal lineage, one Arctic and one non- 660 Arctic (e.g., Baffinella sp. CCMP2293, and Guillardia theta, from cryptomonads (Curtis et al., 2012)) 661 were searched against a composite dataset of Arctic and non-Arctic genomes and transcriptomes 662 from another algal group (e.g., chlorophytes) via LAST (Kiełbasa et al., 2011), and the best-scoring 663 reference sequences (defined by bitscore) to each query gene were recorded. As both Baffinella 664 CCMP2293 and G. theta are of equivalent phylogenetic distance to all chlorophytes, the number of 665 LAST best hits obtained by the Guillardia genome to each reference chlorophyte sequence should act 666 as a predictor of the number of hits obtained by the Baffinella genome, with positive deviations from 667 this, as inferred by linear regression, potentially relating to more recent HGTs between the Baffinella 668 genome and the reference species. A schematic diagram explaining the methodology; and exemplar 669 scatterplot outputs, are provided in Fig. 6- Figure Supplement 1. These analyses were repeated 670 independently for four comparative pairs of Arctic and non-Arctic query genomes (Baffinella 671 CCMP2293 v Guillardia theta; Pavlovales CCMP2436 v Chrysochromulina tobin; Ochromonas 672 CCMP2298 v Nannochloropsis gaditana; and the novel pelagophyte CCMP2097 v Aureococcus 673 anophageferrens), and combined reference libraries generated from the eight algal lineages 674 considered in this study (chlorophytes, chrysophytes, cryptomonads, diatoms, dictyochophytes, 675 dinoflagellates, haptophytes and pelagophytes), with the exception of within-taxon comparisons 676 (e.g., cryptomonad query genomes were not compared to the cryptomonad reference dataset). 677 Details of the scripts, and tabulated LAST best hit frequencies, are provided in Table S4, sheets 2-3; 678 and in the linked supporting database https://osf.io/3pmxb/ (Dorrell et al., 2021b) in the folder 679 “Within-Arctic HGTs”. 680 681 Altogether, 1,322 genes from Arctic genomes that either retrieved an Arctic LAST best hit when 682 searched against at least one of the algal reference libraries; or that themselves were retrieved as 683 LAST best hits; or corresponded to MMETSP transcripts retrieved as LAST best hits to another Arctic 684 genome query were used as seed sequences for subsequent identifications of within-Arctic HGT 685 (schematic workflow presented in Fig. 6- Figure Supplement 2). Briefly, these seed sequences were 686 searched by BLASTp against a previously assembled composite reference library (Dorrell et al., 2019; 687 Dorrell et al., 2021a) containing a complete copy of UniRef (Suzek et al., 2007); all JGI algal 688 genomes (Grigoriev et al., 2021); and decontaminated copies of the MMETSP (Keeling et al., 2014; 689 Marron et al., 2016) and OneKP transcriptomes (Carpenter et al., 2019; Initiative, 2019); along with 690 independently sequenced reference transcriptomes e.g., from diatoms (Dorrell et al., 2021a) and 691 chrysophytes (Beisser et al., 2017); and here manually annotated by isolation site (Arctic, Antarctic or 692 Other as defined above). 229 genes that (i) did not yield a BLAST best hit against the same taxonomic 693 group as the query (Baffinella sp. CCMP2293 : cryptomonads; Pavlovales sp. CCMP2436 : 694 haptophytes; Ochromonas sp. CCMP2298 : chrysophytes and novel pelagophyte CCMP2097 : 695 pelagophytes) and (ii) included at least one Arctic species in the best ten BLASTp hits were retained 696 for subsequent analysis. Query genes searched are provided in Table S4, sheet 4; and the ten best 697 BLASTp hits for each query sequence in Table S4, sheet 6. 698 699 A full set of orthologues were assembled for each retained query sequence by retrieving the LAST 700 best hit for 151 non-redundant taxonomic groups from the all tree of life library used above (Dorrell

701 et al., 2019; Dorrell et al., 2021a); the pan-algal dataset of genomes and transcriptomes used in this 702 study; and a further set of 33 eukaryotic reference genomes and 59 prokaryotic reference genomes, 703 sampled to include diverse representation from the tree of life, including multiple Arctic and 704 Antarctic prokaryotes (Table S4, sheet 5); along with all sequences identified from the genomes and 705 MMETSP transcriptomes of each of the four Arctic algae sequenced in this study that could be 706 retrieved by LAST with threshold e-value 10-05. Clusters for pairs of seed sequences that were found 707 to show greater similarity to one another than any non-seed sequence within the cluster via internal 708 BLAST searched were merged, yielding 215 merged gene clusters of non-redundant seed sequences 709 and a total set of approx. 300-500 orthologues from across the tree of life (Fig. 6- Figure Supplement 710 2). 711 712 Alignments were constructed for each merged gene cluster using MAFFT with the --auto setting; 713 followed by a second round of alignment with the --gap_open_penalty 12 --gap_extension_penalty 3 714 --max_iteration 2 settings; then trimmed using TrimAl with the –gt 0.5, -resoverlap 0.75 and - 715 seqoverlap 0.8 settings; followed by a final round of alignment with MAFFT (Capella-Gutiérrez et al., 716 2009; Katoh et al., 2017). Clusters containing poorly aligned or fragmented seed sequences were 717 manually identified and rejected at each step, retaining 129 approved gene clusters (Fig. 6- Figure 718 Supplement 2). Approved gene clusters were used to generate RAxML consensus trees, with 300 719 bootstrap replicates and the PROTGAMMAJTT substitution model. 21 of the realised trees were 720 found to contain monophyletic groups of multiple Arctic species with > 50% bootstrap support; and a 721 further 13 contained groups consisting of a majority of Arctic species with some Antarctic or non- 722 polar species, with > 50% support for the ancestral node (Fig. 6- Figure Supplement 2; Table S4, Sheet 723 9). Finalised alignments and consensus tree topologies are provided in Table S4, sheets 7-8; and all 724 intermediate alignment processing steps, and individual bootstrap replicates for each tree, are 725 provided in the linked supporting database https://osf.io/3pmxb/ (Dorrell et al., 2021b) in the folder 726 “Candidate HGT trees”. 727 728 Inferred functions were inspected for all genes from each Arctic query genome identified at each 729 stage of the pipeline (all decontaminated genes; all genes with a within-Arctic LAST best hit; all genes 730 with an Arctic top ten BLAST best-hit; and all genes confirmed by single-gene trees to be participants 731 of within-Arctic HGTs). The assessed functions included KEGG and KOG annotations, assessed by 732 BlastKOALA and GhostKOALA (Kanehisa & Sato, 2020); PFAM domains, inferred by 733 InterProScan (Jones et al., 2014); absolute and ranked rpkm values of transcripts corresponding to 734 each gene in corresponding MMETSP transcriptomes derived under different physiological conditions 735 (Terrado et al., 2015); and predicted subcellular localisations, inferred using ASAFind v 2.0 used in 736 conjunction with Signal P v 3.0 (Gruber, Rocap, Kroth, Armbrust, & Mock, 2015), HECTAR using a 737 default scoring matrix (Gschloessl, Guermeur, & Cock, 2008), and WolfPSort, taking the consensus 738 annotations obtained with animal, fungal and plant reference models (Horton et al., 2007). 739 Tabulated functions associated with each sequence, and two-tailed chi-squared enrichment values 740 for each function in within-Arctic HGTs, are provided in Table S4, sheets 9-12. 741 742 Finally, Tara Oceans unigenes corresponding to within-Arctic HGTs were identified by hmmer using 743 HMMs composed of all Arctic isolate sequences from the untrimmed alignments for each gene 744 family, as above. Peptide sequences of the unigenes retrieved using this approach were first 745 searched against all sequences in the corresponding gene family alignment by BLASTp with the -

746 max_target_seqs 1 parameter. Unigenes that yielded a best BLAST hit against an Arctic species were 747 realigned against the gene family alignment with mafft under the --auto setting; and used to build 748 neighbour-joining trees with 100 replicates in GeneIOUS v. 10.0.9. Unigenes that mapped to within- 749 Arctic HGT clade within these trees were extracted, and used to calculate total relative 750 environmental abundances across all depths and size fractions in Tara Oceans data, as above. Details 751 of the BLAST outputs, alignments, phylogenetically reconciled TARA sequences and relative 752 abundance calculations, are provided in Table S4, sheets 10-11; and in the linked supporting 753 database https://osf.io/3pmxb/ (Dorrell et al., 2021b) in the folder “Within-Arctic HGTs”. 754 755 Data deposition

756 The genome assemblies and annotations are available from JGI PhycoCosm portal (Grigoriev et al., 757 2021)and have been deposited in DDBJ/ENA/GenBank with the following URLs and NCBI accessions: 758 CCMP2293:https://phycocosm.jgi.doe.gov/Crypto2293_1, PRJNA223438; CCMP2436: https:// 759 phycocosm.jgi.doe.gov/Pavlov2436_1 PRJNA223446; CCMP2298:https:// 760 phycocosm.jgi.doe.gov/Ochro2298_1, PRJNA171379; CCMP2097:https:// 761 phycocosm.jgi.doe.gov/Pelago2097_1, PRJNA210205;.

762 All additional supporting data, including the composition of the global and taxonomic reference 763 datasets used in this study; comparisons to previously published genome assemblies (Armbrust et al., 764 2004; Derelle et al., 2006; Gobler et al., 2011; Grigoriev et al., 2021; Hovde et al., 2015; Lin et al., 765 2015; Lommer et al., 2012; Mock et al., 2017; Radakovits et al., 2013; Rastogi et al., 2018; Read et al., 766 2013; D. M. Wang et al., 2014; Worden et al., 2009); 18S, 16S and multigene trees; Tara Oceans 767 Expedition calculations; phylPCA, CAFE and PFAM frequency analyses; LAST and phylogenetic 768 analyses of within-Arctic HGTs and Arctic-specific gene expansions and contractions are provided via 769 a dedicated osf.io database (Dorrell et al., 2021b) https://osf.io/3pmxb/. Data is classified within 770 this database by project, each of which contains an associated README file describing the folder 771 contents, and associated methodology for its production.

772 Author contributions

773 CL isolated the strains and coordinated the global study. MP and REE grew and maintained the 774 culture, with MPB responsible for nucleic acid isolation and quality control. KB, JS, and IVG 775 coordinated genome projects, and RGD coordinated functional analysis of each species. AK, JJ, LH, 776 AS, CP, AL, YP and KL produced the genome data; and RGD, AK, ASS, NZ, ZF, FI, JJPK and ER analysed 777 the genome data. AMGNV, JM, NJF, FRJV, VL, BH, JBD, CdV and PW provided additional supporting 778 data. RGD, AK, ER, ZF, CL, CB and IVG wrote the manuscript with comments on different sections by 779 co-authors.

780 Acknowledgments

781 The work conducted by the U.S. Department of Energy Joint Genome Institute, a DOE Office of 782 Science User Facility, is supported by the Office of Science of the U.S. Department of Energy under 783 Contract No. DE-AC02-05CH11231. RGD and AMGNV acknowledge funding from a CNRS Momentum 784 Fellowship (2019-2021) awarded to RGD. CL received support from the Discovery program of Natural 785 Science and Engineering Council (NSERC, Canada) and a pilot project grant from Genome Québec. CB 786 acknowledges funding from the European Research Council (ERC) under the European Union’s 787 Horizon 2020 research and innovation programme (grant agreement No. 835067; Diatomic), the

788 French Government ‘Investissements d’Avenir’ programmes MEMO LIFE (ANR-10-LABX-54), PSL* 789 Research University (ANR-1253 11-IDEX-0001-02), France Génomique (ANR--10-INBS-09) and 790 OCEANOMICS (ANR-11-BTBR-0008), and Research Grant ‘Green Life in the Dark’ (RGP0003/2016) 791 from the Human Frontier Science Program. CB, FMI and JJPK acknowledge support from ECOS Sud- 792 Argentine program (AT08ST18). ZF acknowledges support from the J.W. Fulbright Commission of the 793 Slovak Republic and computational resources supplied by the project "e-Infrastruktura CZ" (e-INFRA 794 LM2018140) provided within the program Projects of Large Research, Development and Innovations 795 Infrastructures. The authors thank E. Virginia Armbrust (University of Washington) and Jackie Collier 796 (Stony Brook Univ. New York) for permission to use a Pseudo-nitzschia multiseries genome for 797 comparative PFAM analysis, and Aplanochrytrium kerguelense, Auriantiochytrium limacinum, and 798 Schizochytrium aggregatum transcriptomes for phylogenetic dataset construction, respectively. The 799 authors respectfully acknowledge that the research within this project benefits from the sampled 800 indigenous biodiversity of the Inuit Nunangat, and was partially performed on the traditional lands 801 and Treaty 6 and unceded territories of multiple First Canadian Nations. This article is contribution 802 number XX of the Tara Oceans project. 803 804 Figures

805

806 Fig. 1. Distant evolutionary relationships of Arctic and Antarctic algae. Consensus ML topology of a 807 391 taxa x 39,504 aa alignment based on 250 conserved single-copy nuclear genes from across the 808 eukaryotic tree of life (22); supplemented with all genomes and MMETSP transcriptomes from eight 809 algal groups (cryptomonads, chlorophytes, chrysophytes, dictyochophytes, diatoms, dinoflagellates, 810 haptophytes and pelagophytes) with at least one sequenced Arctic species. Branch colour 811 corresponds to the phylogeny, and text colour the isolation site of each species considered. All 812 sequenced algal genomes, sequenced Arctic and Antarctic algal species, and taxonomically 813 representative taxa for each algal group are labelled. Genome libraries sequenced in this study are 814 shown with blue circles.

(i) 18S v4 (ii) 18Sv9 (iii) 16S v4v5

90 0% 100% 90 0% 100% 90 0% 100% Arctic

60 60 60

30 30 30

0 0 0 1 10 100 1000 1 10 100 1000 10000 1 10 100 1000

-30 -30 -30

Southern

-60 -60 -60 Antarctic

Ocean / -90 -90 -90

Relative number mapped ribotypes (parts per million total ribotypes)

815 Baffinella sp. CCMP2293 ● Pavlovales sp. CCMP2436 ● Novel pelagophyte CCMP2097 ● Ochromonas sp. CCMP2298

816 Fig. 2. Arctic-specific distributions of sequenced algal genomes. Bell distributions of the total 817 number of 18S V9, 18S V4, and 16S V4V5 ribotypes from Tara Oceans from the four sequenced algal 818 taxa. Each point in each scatterplot corresponds to a Tara Oceans station, showing the relative 819 proportion of ribotypes (expressed in parts per million total ribotypes) reconciled to each species 820 from the surface and 3-20 μm (Arctic) or 5-20 μm (all other stations) size fractions. The lines show 821 normal distributions of these abundances centred around the mean latitude at which each species is 822 observed.

823

824 Fig. 3. Convergence of PFAM domain contents of Arctic-specific algae. Violin plots of Bray-Curtis 825 indices calculated between PFAM distributions of pairs of algal genomes (top) or transcriptomes 826 (bottom), separated by habitat: Arctic (isolation site > 60°N), Antarctic (isolation site > 55°S) or Other 827 (all intermediate latitudes). Comparisons between members of the same taxonomic group, and 828 involving either freshwater or obligately non-photosynthetic species were excluded from the 829 analyses. Genomic calculations involving Antarctic species are not shown due to the presence of only 830 one Antarctic genome (Fragilariopsis cylindrus) in the pan-algal dataset. Significance values of one- 831 way ANOVA tests of the separation of means (red dots) are provided between Arctic-Arctic species 832 pairs, and all other forms of species pairs considered.

833

834 Fig. 4. Arctic-specific expansions and contractions of PFAM domains. Scatterplot of 3,858 PFAMs, 835 detected in at least one algal genome and one algal transcriptome, and having inferred to have 836 undergone at least one expansion or contraction by CAFE of genome data and at least one expansion 837 and contraction by CAFE of transcriptome data; showing possible enrichments and depletions in

838 Arctic species. The horizontal axis shows the signed -log10 chi-squared P-value of the presence of 839 PFAMs in Arctic versus non-Arctic species in the dataset. Positive values indicate the PFAM occurs 840 more frequently than expected in Arctic species; and negative values that the PFAM occurs less

841 frequently than expected in Arctic species. The vertical axis shows the -log10 chi-squared P-values for 842 enrichment in expansions of each PFAM, inferred by CAFE, in Arctic compared to non-Arctic species,

843 minus the –log10 chi-squared P-values of contractions in each PFAM in Arctic species, using the same 844 methodology. Positive values indicate the PFAM is more frequently expanded in Arctic species and 845 negative that it is more contracted in Arctic species than expected. PFAMs that are inferred to either 846 be specifically associated (enriched in presence, or expanded) or not associated (contracted) in Arctic 847 compared to non-Arctic species (P < 10-05) are labelled. One PFAM (PF11999, ice-binding domain) 848 showing extreme enrichment in Arctic species is shown off-scale.

849

850 Fig. 5. HGT of ice-binding domain sequences between Arctic algae. Consensus best-scoring tree 851 topology obtained with RaxML under JTT and WAG substitution models for a 4862 branchx193 aa 852 alignment of all ice-binding domain (PF11999) sampled from UniRef, JGI algal genomes, MMETSP, 853 and Tara Oceans. Branches are shaded by evolutionary origin and leaf nodes by biogeography 854 (either: isolation location of cultured accessions where recorded; or on oceanic regions for which > 855 70% total abundance of each Tara unigene could be recorded). One Tara unigene (asterisked) shows 856 bipolar distributions (> 35% total abundance in both Arctic and Antarctic/ Southern Oceans). Thick 857 branches indicate presence of a clade in both best-scoring tree outputs. The tree in the centre shows 858 an overview of the global topology obtained; four clades of algal IBPs with probable within-Arctic 859 transfer histories and two clades of algal IBPs with probable within-Antarctic IBPs are shown as 860 magnified circular topologies. Numbers in parentheses identify the number of non-identical branches 861 (i.e., gene sequences) identified in each named species. The earliest-diverging branch in each clade, 862 relative to the remaining global tree topology, is marked with an arrow. From these rooting points, 863 probable horizontal transfer events can be inferred e.g. from monophyletic groups of sequences, 864 positioned within paraphyletic groups of sequences from a different phylogenetic derivation.

865

866

867

868

869

870

871

872

873

874

875 Fig. 6. Similarity in Arctic algal genome content inferred by LAST top-hit analysis. Scatterplot 876 showing mean (horizontal axis) and median enrichments (vertical axis) in LAST top hits from the 877 complete genomes of comparative pairs of Arctic algal species and phylogenetically equivalent non- 878 Arctic species, searched across taxon-specific reference libraries trom the pan-algal dataset. Species 879 are shaded by phylogenetic origin (inner colour) and biogeographical origin (outer colour). Five Arctic 880 species that show strong enrichments in LAST top-hits to other Arctic queries, plus Pavlovales sp. 881 CCMP2436 which uniquely amongst the four sequenced species does not, are labelled. Deviation

882 values were calculated as (CCMP2097obs – CCMP2097exp|Aureococcus, CCMP2293obs - CCMP2293exp|Guillardia,

883 CCMP2436obs - CCMP2436exp|Chrysochromulina, and CCMP2298obs - CCMP2298exp|Nannochloropsis ) where “obs” 884 is the observed number of best hits for a given reference species and “exp” is the expected number 885 based on linear regression from the number of best hits obtained with the non-Arctic query within 886 the same comparative pair. Searches between query and reference libraries from the same 887 taxonomic group were excluded from all calculations.

888

889

Sequenced Arctic species

30 Sampling latitude latitude Sampling

0 -5 0 5 10 15 20 25 30 35 Sequenced/ known viable temperature (°C)

-30

-60 Chrysophytes Cryptomonads Diatoms Dictyochophytes Dinoflagellates Green Algae Haptophytes Pelagophytes Tara Arctic Ocean Stations Tara Southern Ocean Stations Other Tara Stations

-90

890 Fig. 1- Figure supplement 1. Scatterplot of sampled latitude, and growth temperatures, of all 891 geolocalised algal genomes and transcriptomes within the pan-genomic dataset assembled for this 892 study. Taxa are shaded by phylogeny and biogeography per Fig. 1. Data were manually verified for 893 each culture by comparing the synthesis of the genome and transcriptome portal data (Grigoriev et 894 al., 2021; Keeling et al., 2014) with recorded permissible growth temperatures for each 895 corresponding culture collection accession, taking into account synonymous strain names housed in 896 different collections. Tara Oceans data is taken from PANGAEA entries for each station (Pesant et al., 897 2015). Growth temperatures are provided as ranges, centred around the experimental temperature 898 (if recorded) at which the genome or transcriptome library was generated. The Arctic species 899 sequenced in this study, which are not viable at temperatures > 6C, are surrounded by a blue box.

900 Fig. 1- Figure supplement 2. Phylogenetic position of Baffinella sp. CCMP2293 inferred from 901 cultured 18S sequences. This figure shows the consensus topologies inferred for (left) a 143 taxa x 902 1699 nt 18S rDNA alignment and (right) a 53 taxa x 1178 nt alignment of all cryptomonad NCBI and 903 MMETSP sequences, trimmed to 80% occupancy. The 18S tree is rooted on a Goniomonas outgroup 904 (Cenci et al., 2018) and the 16S tree on the midpoint. Thick branches indicate clade presence in both 905 MrBayes consensus trees obtained. Leaf nodes are shaded by biogeographical origin. MrBayes 906 consensus and RAxML best-scoring tree values retrieved for nodes unifying Baffinella sp. CCMP2293 907 with a clade of mainly Arctic cryptomonads, including the conspecific CCMP2045 (Daugbjerg et al., 908 2018), and with the genus Proteomonas, are shown with red circles.

909

910 Fig. 1- Figure Supplement 3. Phylogenetic position of the novel pelagophyte CCMP2097 inferred 911 from cultured 18S and 16S sequences. Consensus MrBayes and RAxML topologies realised for (i) a 55 912 taxa x 1648 nt 18S alignment; and (ii) a 35 taxa x 819 nt 16S alignment of pelagophyte and 913 dictyochophyte NCBI and MMETSP 18S sequences, rooted between pelagophytes and 914 dictochophytes (Dorrell et al., 2021a), and trimmed to 80% occupancy. Thick bars indicate clade 915 recovery in all tree topologies. Leaf nodes are shaded by biogeographical origin. Support values for 916 nodes, placing CCMP2097 at within a predominantly Arctic clade including the genus Ankylochrysis 917 (Han et al., 2018), are shown with red circles.

918

919 Fig. 1- Figure supplement 4. Phylogenetic position of Pavlovales sp. CCMP2436 inferred from 920 cultured 18S and 16S sequences. Consensus MrBayes and RAxML topologies inferred for (i) a 241 921 taxa x 1679 nt 18S alignment and (ii) a 94 taxa x 846 nt 16S alignment of NCBI and MMETSP 922 haptophyte trimmed to 80% occupancy and rooted on the split between pavlovophyte and 923 prymnesiophyte sequences (Bendif et al., 2011). Thick branches indicate recovery of a clade in both 924 tree topologies. Leaf nodes are shaded by biogeographical origin. Support values for two nodes 925 realised using MrBayes and RAxML, which place CCMP2436 as an isolated basal member of the 926 pavlovophytes,and related to the otherwise non-Arctic genus Diacronema sensu lato, are indicated 927 with red circles.

928 Fig. 1- Figure Supplement 5. Phylogenetic position of Ochromonas CCMP2298 inferred from 929 cultured 18S and 16S sequences. Consensus MrBayes and RAxML topology resolved for (top) a 219 930 taxa x 1636 nt alignment for NCBI and MMETSP 18S rDNA sequences from and (bottom) a 15 taxa x 931 1383 nt alignment (trimmed to remove sites with <80% occupancy) of chrysophytes, synurophytes, 932 and a pinguiophyte outgroup (Dorrell et al., 2021a). Thick branches indicate presence of a node in 933 the MrBayes consensus and RaXML best-scoring tree topology. Leaf nodes are shaded by 934 biogeographical origin. Consensus values retrieved for one node linking CCMP2298 to the mesophilic 935 Ochromonas sp. CCMP1393 (18S) and to Ochromonas sp. CCMP1899 (16S) in trees calculated with 936 alignments trimmed to 50% and 80% occupancy are shown with red circles.

(i) Depth 46212 751 4992 9006 1031 255 41 1 18 30

v9 v4 16S v9 v4 16S v9 v4 16S 16S Baffinella CCMP2293 Novel pelagophyte CCMP2097 Pavlovales CCMP2436 Ochro. 2298

MES/MXL DCM Surface

(ii) Size fraction

46212 751 4992 9006 1031 255 41 1 18 30

v9 v4 16S v9 v4 16S v9 v4 16S 16S Baffinella CCMP2293 Novel pelagophyte CCMP2097 Pavlovales CCMP2436 Ochro. 2298

0.2 to 1.6/ 3 0.8 to 3/5 3/5 to 20 20 to 180/200 180/ 200 to 2000

937 Fig. 2- Figure Supplement 1. Total read counts of Tara Oceans ribotypes phylogenetically resolved 938 to be closely related to Arctic native species: divided by (i) depth (either surface, deep chlorophyll 939 maximum, or mesopelagic/ mixed layer), and (ii) size fraction. Each species is predominantly 940 distributed in surface waters, small (3-5/ 20 μm) size fractions, and Arctic stations. The total numbers 941 of reconciled ribotypes are shown on the above each plot. Samples with no mapped ribotypes 942 (Ochromonas sp. CCMP2298 was not detected in 18S v4 or 18S v9 ribotype data hence these values 943 are not shown).

(i) Baffinella sp. CCMP2293 (ii) Novel pelagophyte CCMP2097

90 90

60 60

30 30

0 0 -200 -150 -100 -50 0 50 100 150 200 -200 -150 -100 -50 0 50 100 150 200

-30 -30

3 000 1 000 1 500 500 600 200 -60 150 -60 50

v9 0.8-2000 v4 0.8-2000 16S 0.8-2000 v9 3/5-20 v4 3/5-20 16S 3/5-20 v9 0.8-2000 v4 0.8-2000 16S 0.8-2000 v9 3/5-20 v4 3/5-20 16S 3/5-20 -90 -90

(iii) Pavlovales sp. CCMP2436 (iv) Ochromonas sp. CCMP2298

90 90

60 60

30 30

0 0 -200 -150 -100 -50 0 50 100 150 200 -200 -150 -100 -50 0 50 100 150 200

-30 -30

30 200 15 100 6 40 -60 2 -60 10

v4 0.8-2000 16S 0.8-2000 v9 3/5-20 v4 3/5-20 16S 0.8-2000 16S 0.8- 3/5 -90 -90 944 Fig. 2- Figure Supplement 2. Relative abundances (expressed as parts per million) of 18S v4, 18S v9 945 and 16S v4v5 ribotypes of Arctic isolated algae: (A) Baffinella sp. CCMP2293, (B) novel pelagophyte 946 CCMP2097, (C) Pavlovales sp. CCMP2436 and (D) Ochromonas sp. CCMP2298; calculated from the 947 Tara Oceans and Tara Oceans Polar Circle expeditions. Ribotypes corresponding to each species were 948 identified by BLASTn (threshold similarity 97%) followed by phylogenetic reconciliation to cultured 949 accessions; and abundance calculations are shown for surface samples and size fractions (0.8- 2000 950 and 3/5-20 μm) in which the greatest number of corresponding OTUs were counted.

(i) 18S v4 ribotypes (ii) 18S v9 ribotypes (iii) 16S v4v5 ribotypes

30 30 30 25 25 25 20 20 20 15 15 15

Indian Ocean Indian Ocean Indian Ocean 10 10 10 5 5 5 0 0 0 -5 1 -5 1 -5 1 10 100 1000 10 100 1000 10 100 1000 Ocean Atlantic North Ocean Atlantic North North Atlantic Ocean Atlantic North

South Pacific Ocean South Pacific Ocean South Pacific Ocean

(iv) 18S v9 ribotypes (v) 16S v4v5 ribotypes

30 30

25 25

20 20

15 15 Key

10 Indian Ocean 10 Indian Ocean Baffinella sp. CCMP2293 5 5 Novel pelagophyte CCMP2097 0 0 Pavlovales sp. CCMP2436 Ochromonas sp. CCMP2298 -5 -5 2 8 32 2 8 32 North Atlantic Ocean Atlantic North Ocean Atlantic North Temperature (°C) Relative ribotype abundance (ppm) Oceanic province

South Pacific Ocean South Pacific Ocean

951 Fig. 2- Figure Supplement 3. Cold water preferences of Arctic native algae. This figure shows radar 952 plots of the relative abundances of (i-iii) Baffinella sp. CCMP2293 and the novel pelagophyte 953 CCMP2097; (iv) Pavlovales sp. CCMP2436 and (v) Ochromonas sp. CCMP2298 in the 3/5-20 μm size 954 fraction and surface samples of Tara Oceans station, divided by station provenance, and compared to 955 environmental temperature. All four species show strong localisation preferences to cold stations in 956 the Northern hemisphere (i.e. the Arctic Ocean) without an equivalent enrichment in cold Southern 957 Ocean stations.

958

959

(i) Genomes phylPCA

1200

1000 Key 800 Chlorophytes 600 Chrysophyte relatives Cryptomonads

400 Diatoms Dictyochophytes Dinoflagellates

PC2:30.6% Pelagophyte200 CCMP2097 Pavlovales CCMP2436 Pelagophytes Haptophytes 0 Arctic species -1000 -500 0 500 1000 1500 2000 Ochromonas CCMP2298 Antarctic species -200 Other species

Baffinella CCMP2293 -400

-600 PC1: 36.9%

(ii) Transcriptomes phylPCA

400

Polarella glacialis Heterocapsa arctica

300

200

100

Entomoneis sp. Mantoniella beaufortii 0 Minutocellus polymorphus -1400 -1200 -1000 -800 -600 -400 -200 0 200 400 600 800 1000 Micromonas polaris Pyramimonas CCMP2087 Attheya septentrionalis Micromonas CCMP2099 -100 Chaetoceros neogracile PC2:9.6%

-200 Pavlovales CCMP2436 Ochromonas CCMP2298 Pelagophyte CCMP2097

-300

-400 Baffinella CCMP2293

Dictyochophyte CCMP2098 -500

-600 PC1: 71.9%

960 Fig. 3- Figure Supplement 1. Phylogenetically-aware principal component analyses of PFAM 961 content in the pan-algal dataset, separately realised (i) for genome and (ii) for transcriptome data. 962 Full coordinate values are provided in Table S2, sheet 6. Each coordinate point is coloured by 963 phylogeny (fill) and biogeographical origin (line). The all other Arctic species in the datasets are 964 labelled.

965

A B 1 1

500 0.8 0,8

200

0.6 0,6 Bray-Curtis 100

PFAM PFAM BUSCO-normalised

50 0.4 0,4 Spearman

0.2 0,2

73 75 15 80 62 0 0 % BUSCO coverage Reference A Reference B Reference C Reference D Reference A Reference B Reference C Reference D Query library

1 1 Species 1 2 3 4 5 6 7 8 9 10 11 12 D

. .

C ...... Lineage 0.8 0,8 Chl Chl Chl Chl Chl Chl Hap Hap. Hap. Hap. Hap. Hap

...... 0.6 0,6 Library Gen Gen Gen Gen

Trans Trans Trans Trans Trans Trans Trans Trans

0,4

. . 0.4 Species Lineage Library Habitat NP NP FW Ant Ant

0,2 Other Other Other Other Arctic Arctic Arctic Arctic 0.2 1 Chlorophyte Genome Arctic A B

0 2 Chlorophyte Genome Other B C 0 3 Chlorophyte Transcriptome Arctic D E G 4 Chlorophyte Transcriptome Other E F 5 Chlorophyte Transcriptome Antarctic G H 6 Chlorophyte Transcriptome Freshwater 7 Haptophyte Genome Arctic A B 8 Haptophyte Genome Other B C 9 Haptophyte Transcriptome Arctic D E G 10 Haptophyte Transcriptome Other E F 11 Haptophyte Transcriptome Antarctic G H 12 Haptophyte Transcriptome Non-Photosynthetic

966 Fig. 3- Figure Supplement 2. Exemplar calculations of PFAM convergence. A: bubble plot showing 967 the distribution of 30 PFAMs in five hypothetical libraries. The query library is convergent to 968 Reference A; Reference B is also convergent, but fragmented; Reference C is also convergent, but 969 with specific expansions in individual PFAMs; and Reference D is non-convergent. B: calculated Bray- 970 Curtis, BUSCO-normalised shared PFAM, and Spearman correlation values between the query library 971 and References A-D. C: exemplar heatmap of pairwise comparisons between 12 libraries, and D: the 972 convergence calculations made between them, shaded per the sampled intersecting cells in the 973 heatmap. Of note, comparisons within individual lineages, between genomes and transcriptomes, 974 and involving either freshwater or non-photosynthetic species were excluded to minimise latitude- 975 independent biases on PFAM convergence estimates.

A BUSCO-adjusted shared PFAMs B PFAM Spearman Rank Index

Genome comparisons Spearman Genomes Genome comparisons BUSCO Key ns

* Genomes ns

350 250 *** Arctic-Arctic ns 0.8 Arctic-Other 0.8 ** Other-Other 200 Arctic-Antarctic Antarctic-Antarctic0.9 0.6 0.6

250 150

* P < 0.05 BUSCO value BUSCO

0.7 PFAMs ** P < 0.01 PFAMs Spearman correlation -05 0.4 100 *** P < 10 0.4

0.5 shared

50 correlation Transcriptome comparisons Transcriptome comparisons Arctic−Arctic Arctic−Other Other−Other Arctic−Antarctic Transcriptome comparisonsArctic−Arctic Arctic−Other Other−Other Arctic−Antarctic

adjusted ns * 2000 ns BUSCO ** **** Spearman

Transcriptomes Transcriptomes Spearman nsns ns **** *******

BUSCO- **** **** *** *** 1.00 **** *** ns 10.9 ***ns * 1500°1500 *****

0.75 0.750.6 10001000 Curtis value − Spearman correlation Bray BUSCO value BUSCO 0.50 0.5 500 500 0.3

0.25 0 0.25 0 0.0 Arctic−Arctic Arctic−Other Other−Other Arctic−Antarctic Antarctic−Antarctic

Arctic−Arctic Arctic−Other Other−Other Arctic−Antarctic Antarctic−Antarctic Arctic−Arctic Arctic−Other Other−Other Arctic−Antarctic Antarctic−Antarctic 976

977 Fig. 3- Figure Supplement 3. Alternative metrics for identification of Arctic-Arctic PFAM 978 convergences. A: violin plot of pairwise numbers of total number of shared PFAMs normalised on % 979 recovered complete (single or duplicated) eukaryotic BUSCOs, and B: violin plot of Spearman 980 correlation coefficients between PFAM distributions; from Arctic, Antarctic and other algal genomes 981 (top) and transcriptomes (bottom) within the pan-genomic dataset. Violin plots are shown as per Fig. 982 3. Comparisons between members of the same taxonomic group, and involving either freshwater or 983 obligately non-photosynthetic species were excluded from the analyses. Genomic calculations 984 involving Antarctic species are not shown due to the presence of only one Antarctic genome 985 (Fragilariopsis cylindrus) in the global dataset. Significance values of one-way ANOVA tests of the 986 separation of means (red dots) are provided between Arctic-Arctic species pairs, and all other forms 987 of species pairs considered.

988

989

i) PFAM convergence; Arctic genomes ii) PFAM convergence; Arctic transcriptomes

1,8 1.8 1,8 1.8

1,6 1.6 1,6 1.6

1.4 1,4 1,4 1.4

1.2 1,2

PFAMs 1,2 1.2

shared

1 0,6 0,8 1 1,2 1,4 1,6 1,8 1 0,6 0,8 1 1,2 1,4 1,6 corrected 0.6 0.8 1 1.2 1.4 1.6 1 0.6 0.8 1 1.2 1.4 1.6 1.8

BUSCO-correctedBray-Curtis enrichment

BUSCO-

Bray-Curtis enrichment Bray-Curtis enrichment 0.8

0,8 0,8 0.8 Novel pelagophyte CCMP2097

Pavlovales sp. CCMP2436 Novel pelagophyte CCMP2097 Baffinella sp. CCMP2293 Pavlovales sp. CCMP2436 0.6 Ochromonas sp. CCMP2298 0.6 0,6 0,6 Baffinella sp. CCMP2293 Arctic dinoflagellates Ochromonas sp. CCMP2298 Dictyochophyte CCMP2098

0.4 Arctic chlorophytes

0.4 0,4

0,4

Convergences involving diatoms All other Arctic convergences

990 Fig. 3- Figure Supplement 4. Convergences in Arctic PFAM content principally involve non-diatom 991 taxa. This figure shows scatterplots of showing crude anti-Bray-Curtis values (horizontal axis), and 992 BUSCO-normalised numbers of shared PFAMs (vertical axis), for similarity in PFAM content between 993 different pairs of Arctic species in the pan-genomic dataset. Each value consists of the convergence 994 value between a given Arctic query species and another Arctic reference, normalised against the 995 mean Bray-Curtis or BUSCO-normalised Bray-Curtis value calculated between the query species 996 against all non-Arctic species belonging to the same algal lineage as the reference. Values of >1 997 indicate a potential convergence in the PFAM content of pairs of Arctic species compared to 998 phylogenetically equivalent references. Plots (i) and (ii) show respectively PFAM convergences 999 involving query Arctic genomes; and PFAM convergences involving query Arctic transcriptomes from 1000 seven algal groups (chlorophytes, chrysophytes, cryptomonads, dictyochophytes, dinoflagellates, 1001 haptophytes and pelagophytes). The outer colour of each point is shaded by the taxonomic origin of 1002 the query species as per Fig. 1. The inner colour of each point is shaded by the taxonomic origin of 1003 the reference species: convergences involving diatom references are shaded brown, and 1004 convergences involving all other reference lineages are dark blue. In each plot, while multiple 1005 combinations of query and reference Arctic species are observed to have normalised convergence 1006 values > 1, suggesting Arctic-Arctic convergences, combinations involving diatom references 1007 strikingly have normalised reference values close to 1, or even less than 1, suggesting limited 1008 convergence in PFAM content between Arctic diatoms and other Arctic algal groups.

Transcriptome comparisons *** *Bray-Curtis index

** ****

**** *** 0.9 ******

0.60.6 Curtis value − Bray 0.30.3 Bray-Curtisvalue

0.00 Transcriptome comparisons Arctic−Arctic Arctic−Other Other−Other Arctic−Antarctic Antarctic−Antarctic ns BUSCO-nsnormalised PFAMs

ns ns 600 *** ****

ns **** Key

PFAMs

Arctic-Arctic 400400 Arctic-Other shared

Other-Other Arctic-Antarctic Antarctic-Antarctic

adjusted BUSCO value BUSCO

200200 * P < 0.05 ** P < 0.01 BUSCO- *** P < 10-05 Genome comparisons

00 ns

Arctic−Arctic Arctic−Other Other**−Other Arctic−Antarctic Antarctic−Antarctic 1.5 **ns Spearman

*** **** *** **** ** 1.01 **

0.750.5 correlation Spearman correlation

0.50.0 Spearman

0.25−0.5 n=48 n=1235 n=7716 n=80 n=31 Arctic−Arctic Arctic−Other Other−Other Arctic−Antarctic Antarctic−Antarctic 1009 Fig. 3- Figure Supplement 5. Violin plots of Arctic-Arctic convergence indices across transcriptome 1010 datasets exclusive of diatoms. Violin plots are shown as per Fig. 3. Diatom-exclusive genome plots 1011 are not shown due to the absence of Arctic diatom genomes from the pan-algal dataset.

1012

1013

PF11999- ice-binding PF11028- DUF2723 PF10551- MULE transposase PF13879- KIAA1340

Ochromonas CCMP2298 Baffinella CCMP2293 Pavlovales CCMP2436

Genomes Novel pelagophyte CCMP2097

Pyramimonas CCMP2087 Micromonas CCMP2099 Micromonas pusilla RCC2306 PFAMS PFAMS Mantoniella beaufortii RCC2288 Ochromonas CCMP2298 Baffinella CCMP2293 Minutocellus polymorphus RCC2270 Expanded Entomoneis CCMP2396 Chaetoceros neogracile RCC1993

Attheya septentrionalis CCMP2084 Dictyochophyte CCMP2098 Polarella glacialis CCMP2088 Heterocapsa arctica CCMP445 Pavlovales CCMP2436 Pelagophyte CCMP2097

Transcriptomes -5 0 5 10 -20 0 20 40 60 80 100 120 -2 0 2 4 6 8 10 -2 0 2 4 6 8 10

PF01232- Mannitol dehydrogenase PF10233- DUF2465 PF13881- Ubiquitin Rad60 PF13424- Tetratricopeptide Ochromonas CCMP2298 Baffinella CCMP2293 Pavlovales CCMP2436 Genomes Novel pelagophyte CCMP2097

Pyramimonas CCMP2087 Micromonas CCMP2099

PFAMS PFAMS Micromonas pusilla RCC2306 Mantoniella beaufortii RCC2288 Ochromonas CCMP2298 Baffinella CCMP2293 Minutocellus polymorphus RCC2270 Contracted Entomoneis CCMP2396 Chaetoceros neogracile RCC1993 Attheya septentrionalis CCMP2084 Dictyochophyte CCMP2098 Polarella glacialis CCMP2088 Heterocapsa arctica CCMP445 Pavlovales CCMP2436 Pelagophyte CCMP2097 Transcriptomes -5 -4 -3 -2 -1 0 1 2 3 -2 -1 0 1 2 -4 -2 0 2 4 -50 0 50 100 150 200 250

Frequency of expanded PFAM Frequency of contracted PFAM CAFE change value

1014 Fig. 4- Figure Supplement 1. Bar plots showing (coloured bars) the total number and (grey bars) 1015 CAFE scores, across all studied Arctic species, for four PFAMs (blue) inferred to be significantly more 1016 frequently expanded and four PFAMs (red) significantly more contracted (one-tailed chi-squared 1017 test, P< 10-05) in Arctic compared to non-Arctic species across the pan-algal dataset.

1018

1019 Fig. 5- Figure Supplement 1. Environmental distributions of ice-binding domains in Tara Oceans 1020 data. (Left) global distribution plots, and (right) bar charts of individual proportional abundances of 1021 ice-binding domain (PF11999) containing sequences in (i) Tara Oceans meta-transcriptome and (ii) 1022 meta-genome sequence data, including the Tara Polar Circle survey. Stations are classified into Arctic 1023 (>60N), Antarctic (>55S) and Other latitudes, per Fig. 2. IBD-containing meta-genes show 1024 predominantly polar distributions, which are typically either restricted to the Arctic or Antarctic 1025 stations sampled, with only 4/ 1711 sampled meta-genes represented by >35% of their total global 1026 abundance in both Arctic and Antarctic libraries.

1027

1028

1029

Biogeography Antarctic Antarctic Antarctic Antarctic Arctic Antarctic Antarctic Antarctic Arctic Arctic Arctic Antarctic Arctic Antarctic Arctic Arctic Arctic Arctic Arctic Arctic Hemiboreal

Taxonomy Chlorophyte Chlorophyte Cryptomonad Dinoflagellate Dinoflagellate Diatom Haptophytes Diatom Dinoflagellate Dinoflagellate Pelagophyte Diatom Dictyochophyte Diatom Diatom Chlorophyte Dinoflagellate Cryptomonad Haptophytes Chrysophyte Chrysophyte % Arctic Taxonomy Biogeography

ChlamydomonasMantoniellaGemingera sp. antarcticaPolarella cryophilaPolarella glacialisThalassiosira glacialis CCMP1383Phaeocystis CCMP2088 sp.Proboscia antarcticaScrippsiella sp. Peridinium hangoeiNovel aciculiferum pelagophyteEucampiaCCMP2098 antarctica CCMP2097FragilariopsisEntomoneis sp.Pyramimonas sp.Heterocapsa Baffinellasp. CCMP2087 arcticaPavlovales sp. CCMP2293Ochromonas sp.Pedospumella CCMP2436 sp. CCMP2298 encystans Key

Antarctic Chlorophyte Chlamydomonas sp. 0 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0,0 20

Antarctic Chlorophyte Mantoniella antarctica 0 0 27 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 3,4 15

Antarctic Cryptomonad Gemingera cryophila 3 32 0 3 5 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 11,4 10

Antarctic Dinoflagellate Polarella glacialis CCMP1383 0 2 5 0 0 2 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 18,2 5

Arctic Dinoflagellate Polarella glacialis CCMP2088 0 1 4 0 0 1 1 0 0 0 0 0 0 0 0 0 1 0 1 0 0 22,2 0

Antarctic Diatom Thalassiosira sp. 0 0 0 0 3 20 0 0 6 1 2 0 7 22 1 1 0 0 0 0 0 33,3

Antarctic Haptophytes Phaeocystis antarctica 0 0 0 0 2 0 0 1 1 0 0 0 0 8 0 0 0 0 2 0 0 35,7 Antarctic Antarctic

Antarctic Diatom Proboscia sp. 0 0 0 0 0 0 2 0 0 0 0 0 0 5 0 0 0 0 4 0 0 36,4 Arctic Arctic

Arctic Dinoflagellate Scrippsiella hangoei 0 0 0 1 0 5 0 0 0 0 4 0 0 23 0 11 0 9 2 0 0 47,3 Hemiboreal Hemiboreal

Arctic Dinoflagellate Peridinium aciculiferum 0 0 0 0 0 1 0 0 0 0 2 0 0 18 1 2 0 7 12 0 0 55,8

Arctic Pelagophyte Novel pelagophyte CCMP2097 0 0 0 0 0 3 0 0 1 2 0 0 1 8 1 0 4 4 2 0 0 57,7 Chlorophyte Chlorophyte

Antarctic Diatom Eucampia antarctica 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 1 0 2 0 0 60,0 Chrysophyte Chrysophyte

Arctic Dictyochophyte CCMP2098 0 0 0 0 1 10 0 0 0 0 2 0 0 0 0 0 0 0 0 15 2 64,3 Cryptomonad Cryptomonad

Antarctic Diatom Fragilariopsis sp. 0 0 0 0 0 25 5 1 16 17 8 0 0 0 0 0 0 13 0 0 0 63,5 Diatom Diatom

Arctic Diatom Entomoneis sp. 0 0 1 0 0 3 0 0 3 1 1 0 0 1 0 0 0 7 0 0 0 70,6 Dictyochophyte Dictyochophyte

Arctic Chlorophyte Pyramimonas sp. CCMP2087 0 0 0 1 2 2 0 0 10 2 1 0 4 1 0 0 0 0 0 0 0 82,6 Dinoflagellate Dinoflagellate

Arctic Dinoflagellate Heterocapsa arctica 0 3 1 2 0 0 0 0 0 0 4 1 0 0 0 0 0 4 9 0 0 70,8 Haptophytes Haptophytes

Arctic Cryptomonad Baffinella sp. CCMP2293 0 0 0 0 0 0 2 0 5 8 2 0 0 14 7 0 4 0 34 1 0 79,2 Pelagophyte Pelagophyte

Arctic Haptophytes Pavlovales sp. CCMP2436 0 3 2 0 1 0 0 0 6 15 1 0 0 2 0 1 15 32 0 3 0 91,4

Arctic Chrysophyte Ochromonas sp. CCMP2298 0 0 0 0 0 0 0 0 0 0 0 0 12 0 0 0 0 1 0 0 56 100,0

Hemiboreal Chrysophyte Pedospumella encystans 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 36 0 100,0 1030

1031 Fig. 5- Figure Supplement 2. . Internal BLAST best hit searches within the IBD alignment. This figure 1032 shows the number of times each Arctic- and Antarctic-native eukaryotic algae either retrieves, or is 1033 retrieved, as the best-scoring (lowest e-value) hit in a BLASTp search of the IBD alignment against 1034 itself (Table S3, sheets 3, 8, 9), excluding hits to members of the same genus (with Scrippsiella and 1035 Peridinium treated as congeneric; 38) and Tara Oceans meta-genes. Sequences are shaded by 1036 taxonomy and biogeography as per Fig. 5, and are ranked in ascending order of the % of best-hits 1037 retrieved that are to Arctic eukaryotic algae. Species with fewer than three IBD sequences in the final 1038 alignment are not shown.

Paraburkholderia-phymatum-strain-DSM-17167--CIP-108236--LMG-21445--STM815_B2JLQ1

Acinetobacter-radioresistens-DSM-6976-=-NBRC-102413-=-CIP-103788_A0A0E2GIB4

Enterobacter-agglomerans_A0A379LRG2

Acinetobacter-venetianus-strain-ATCC-31012--CIP-110063--RAG-1_N8ZZ40

Acinetobacter-oleivorans-strain-JCM-16667--KCTC-23045--DR1_D8JNF2 Acinetobacter-bouvetii-DSM-14964-=-CIP-107468_N9CBT2 Acinetobacter-baumannii-951631_A0A009R1M2 Acinetobacter-baumannii-754286_A0A062F244 Acinetobacter-baumannii-625974_A0A009PTI7 Acinetobacter-tandoii-DSM-14970-=-CIP-107469_R9B9U8 Acinetobacter-gerneri-DSM-14967-=-CIP-107464_N8ZH97

Acinetobacter-sp-1566109_A0A010JSZ3

Acinetobacter-sp-ANC-4558_A0A241W139 Acinetobacter-bohemicus-ANC-3994_N8P1U0 Acinetobacter-sp-WCHAc010034_A0A3B7PYC7Acinetobacter-baumannii_A0A429LDU1 Acinetobacter-baumannii_A0A1S2FLA3Acinetobacter-baumannii_A0A333XJC4 Cronobacter-turicensis-strain-DSM-18703_C9Y595

Acinetobacter-sp-ANC-4654_A0A241WTS4 Cronobacter-universalis-NCTC-9529_A0A376KTU7 Prokaryotes-Bacteria-Zetaproteobacteria_Zetaproteobacteria-bacterium-CG1_A0A1J4YDV4Acinetobacter-sp-ANC-3903_A0A1Y3CDQ6 Ferrovum-sp-PN-J185_A0A149VPQ7Acinetobacter-kyonggiensis_A0A1H3GUZ5Acinetobacter-sp-ANC-4169_A0A1Y3D0N1Shewanella-frigidimarina-strain-NCIMB-400_Q07W89 Acinetobacter-bereziniae-NIPH-3_N8YR61Acinetobacter-sp-WCHAc010052_A0A3B7M3Z4 Cupriavidus-metallidurans-strain-ATCC-43123--DSM-2839--NBRC-102507--CH34_Q1LCE2Acinetobacter-guillouiae-NIPH-991_N8YB43 Kosakonia-sp-CCTCC-M2018092_A0A3G9BI24 Paraburkholderia-graminis-strain-ATCC-700544--DSM-17151--LMG-18924--NCIMB-13744--C4D1M_B1G000Acinetobacter-sp-JW_A0A372BGW0 Luteibacter-sp-UNCMF366Tsu51_A0A1K1MVE3 Deltaproteobacteria-bacterium-HGW-Deltaproteobacteria-13_A0A2N2J1B5Acinetobacter-baumannii_R4L7M5 Acinetobacter-pittii_A0A4Q7C3D2Acinetobacter-sp-ANC-4281_A0A4R0EQP9 Acinetobacter-bereziniae_A0A5C4TZ04Acinetobacter-sp-ANC-5600_A0A1T1GV52 Acinetobacter-pittii_A0A4Q7BUP6 Curtobacterium-plantarum_A0A3M7U4F6

Enterobacteriaceae-bacterium_A0A351NLC3 Acinetobacter-guillouiae_A0A077L0Q0Acinetobacter-sp-ANC-4204_A0A241V3A5 Methylophaga-aminisulfidivorans-MP_F5T0U0 Ferrovum-sp-37-45-19_A0A257U8L1Acinetobacter-sp-WCHAc060041_A0A371YNT9 Pseudomonadales-bacterium-32-42-5_A0A258AGN7 Acinetobacter-sp-WCHAc060007_A0A3A8FEG0Acinetobacter-kyonggiensis_A0A1H3NPW1

Pantoea-vagans-strain-C9-1_D6YQA7

Acinetobacter-sp-ANC-3813_A0A241WBN6 Thiorhodovibrio-sp-970_H8Z628 Acinetobacter-sp-SWAC57_A0A373BDH2 Acinetobacter-sp-KPC-SM-21_A0A2U3N1F1 Pantoea-sp-JKS000250_A0A2V3SA34 Moraxellaceae-bacterium_A0A4V2ABF0Acinetobacter-chinensis_A0A3B7M1M0 Acinetobacter-baumannii-146457_A0A009KUW3Acinetobacter-nosocomialis-P020_A0A1Y5NKZ0 Cronobacter-condimenti-1330_K8AD63 Acinetobacter-wuhouensis_A0A4Q7ANS9Acinetobacter-wuhouensis_A0A385C4K1Acinetobacter-sp-ANC-3781_A0A4R0FJE9 Cronobacter-dublinensis-1210_K8B8P7 Acinetobacter-gandensis_A0A1A7RAN3Shewanella-livingstonensis_A0A3G8LP20 Acinetobacter-wuhouensis_A0A3G2T2Z0Acinetobacter-bouvetii_A0A4Q7AZB0Acinetobacter-sp-ACNIH2_A0A2L0I0K3Acinetobacter-sp-SFB_A0A178G6W4Acinetobacter-brisouii-CIP-110357_V2U8W9 Cronobacter-dublinensis-582_K8BGF2 Acinetobacter-sp-ANC-3862_N9NG53Acinetobacter-sp-SFC_A0A178GCZ6

Acinetobacter-sp-38-8_A0A1Q3N8B3 Cronobacter-malonaticus_A0A423XYE3

Acinetobacter-sp-NIPH-284_N9KEA1 Acinetobacter-genomosp-33YU_A0A1V2V203 Pantoea-sp-FDAARGOS_A0A2J9E948 Acinetobacter-sp-AG1_A0A0M3AGX7 Acinetobacter-colistiniresistens_A0A558FAI9Acinetobacter-calcoaceticus-ANC-3811_R8Y0S8 Cronobacter-turicensis_A0A2T7B336Enterobacter-cloacae-S611_V5ATF6 Acinetobacter-sp-NIPH-236_N8PIZ0 Kalamiella-piersonii_A0A3A9IG22Pantoea-sp-paga_A0A555ZNY2 Acidobacteria-bacterium_A0A2V8SFZ9Acinetobacter-pragensis_A0A151Y334 Acinetobacter-gyllenbergii-NIPH-230_V2UNG1 Cronobacter-sakazakii_A0A3Q9CL80 Acinetobacter-sp-ANC-4999_A0A1Y3CHH4 Acinetobacter-sp-ANC-4641_A0A4R0CZ57Acinetobacter-sp-ANC-4635_A0A4R0DEY0 Cronobacter-sakazakii_A0A2S9U8H3 Methylophaga-aminisulfidivorans-MP_F5SX81Acinetobacter-calcoaceticus_A0A4R1Y0S2Acinetobacter-sp-ANC-3832_A0A241WEA7Acinetobacter-sp-SFC_A0A178GDV4 Candidatus-Burkholderia-verschuerenii_A0A0L0MG39 Cronobacter-sakazakii_A0A222ZDE3Enterobacter-sp-kpr-6_A0A1I6CZ12Pantoea-sp-RIT388_A0A3N4NT21Pantoea-sp-OV426_A0A1I5EDH3 Acinetobacter-sp-ANC-4648_A0A1Y3D2S0 Methylovorus-glucosetrophus-strain-SIP3-4_C6XA63 Eumeta-variegata_A0A4C1YTP7 Acinetobacter-defluvii_A0A2S2FHQ8Acinetobacter-piscicola_A0A4V1W1Q2Acinetobacter-sp-SFB_A0A178FYL5Shewanella-frigidimarina_A0A119CZ11 Acinetobacter-sp-ANC-4910_A0A4R0DN85 Kosakonia-cowanii_A0A410KB55 Acinetobacter-sp-SWAC5_A0A372FN26 Pantoea-sp-YU22_A0A432B1B0 Acinetobacter-cumulans_A0A3A8GQ01Acinetobacter-cumulans_A0A4P8DUU8 Acinetobacter-johnsonii-XBB1_A0A0U3T836Acinetobacter-johnsonii-ANC-3681_N9BEP9 Acinetobacter-celticus_A0A1C3CTD4 Acinetobacter-sp-FDAARGOS_A0A4V7TIP1 Acinetobacter-nosocomialis_A0A2T7FGU5 Pantoea-sp-M_A0A5M7NMS2

Cronobacter-malonaticus_V5U4Q5 Methylotenera-mobilis-strain-JLW8--ATCC-BAA-1282--DSM-17540_C6WYA2 Psychrobacter-sp-Sarcosine-3u-12_A0A2N0ZVR2Acinetobacter-sp-1566109_A0A010KY96Candidatus-Burkholderia-pumila_A0A0J7JQP2Paraburkholderia-diazotrophica_A0A1H7BB65 Aeromonas-hydrophila-subsp-hydrophila_A0A2R4TX74 Acinetobacter-colistiniresistens_S3TC98Acinetobacter-sp-WCHA55_A0A385N7E7 Pantoea-dispersa_A0A518XJ18Pantoea-deleyi_A0A506QJA3 Shewanella-sp-ALD9_A0A2N1EHU1Acinetobacter-colistiniresistens_N9R6M6Acinetobacter-sp-ANC-4178_A0A4R0EUX0Acinetobacter-sp-NBRC-100985_G7GGS0Acinetobacter-calcoaceticus_A0A0A8XIB0 Erwinia-citreus_A0A358L9X4 Acinetobacter-baumannii_A0A3R9Q6T8Acinetobacter-sp-216872_A0A140QL27 Nitrospirillum-amazonense_A0A560HI52 Paraburkholderia-piptadeniae_A0A1N7RLC9 Pantoea-sp-PSNIH6_A0A2P5IPI6 Acinetobacter-sp-ANC-3789_N8V7A9Acinetobacter-proteolyticus_A0A2N0WFH7Acinetobacter-venetianus_A0A150HLB7 Pantoea-sp-351_A0A0F5XY14 Acinetobacter-sp-NIPH-1847_N9NXU2Acinetobacter-baumannii_A0A334U6V6 Paraburkholderia-caribensis-MBA4_A0A0P0REL5 Acinetobacter-proteolyticus_A0A1E7R0P6Acinetobacter-venetianus_A0A137XTR9 Caballeronia-grimmiae_A0A069NQQ5 Acinetobacter-sp-CIP-642_N9MWR0Acinetobacter-johnsonii-SH046_D0SAG2Acinetobacter-baumannii_A0A0B2XY16Acinetobacter-sp-25977_A0A014AXN6 Verrucomicrobia-bacterium_A0A2V5M5L4 Acinetobacter-sp-yr461_A0A1H8QLX1 Pantoea-latae_A0A1V9DCK8 Psychrobacter-cryohalolentis-strain-K5_Q1Q9K0Psychrobacter-phenylpyruvicus_A0A379LJ29 Methylophaga-sulfidovorans_A0A1I3ZHE3Verrucomicrobia-bacterium_A0A2V5Q0S9 Acinetobacter-oleivorans_A0A2T5QAV2 Xanthomonadales-bacterium-63-13_A0A1Q4FPZ6Chthoniobacterales-bacterium_A0A2W5ZB27 Acinetobacter-johnsonii_A0A5C0U8T2Acinetobacter-johnsonii_A0A380TTF2 Betaproteobacteria-bacterium-HGW-Betaproteobacteria-20_A0A2N2S633Verrucomicrobia-bacterium_A0A2V5ZSQ5 Acinetobacter-johnsonii_A0A1R7Q8T4 Acinetobacter-sp-CIP-110321_R9B1Q5Acinetobacter-johnsonii_A0A3S9AIW5 Microcystis-aeruginosa-PCC-9443_I4G506 Acinetobacter-sp-WC-323_K9AZ40Acinetobacter-seifertii_A0A1Y3F816Acinetobacter-seifertii_A0A2M8MFI5 Verrucomicrobia-bacterium_A0A2V5NN28 Acinetobacter-seifertii_A0A5E9PES1 Pantoea-sp-aB_E0LTI0 Verrucomicrobia-bacterium_A0A2V6DNB6Verrucomicrobia-bacterium_A0A2V6JR13Verrucomicrobia-bacterium_A0A2V5Z849 Acinetobacter-sp-ANC-3880_N9TKK8Acinetobacter-sp-OIFC021_L9MES6 Verrucomicrobia-bacterium_A0A2V6HEU7Verrucomicrobia-bacterium_A0A2V5RPY6Verrucomicrobia-bacterium_A0A2V5KIN7 Acinetobacter-sp-ANC-4105_N9L9B5 Caballeronia-ptereochthonis_A0A157ZEJ0 Paraburkholderia-ginsengiterrae_A0A1A9N514 Gammaproteobacteria-bacterium_A0A4Q5Q4H4Verrucomicrobia-bacterium_A0A2V5TBI1Verrucomicrobia-bacterium_A0A2V6L6I6 Acinetobacter-sp-ANC-3929_N9LPX2Acinetobacter-sp-NIPH-542_N9S5B0 Paraburkholderia-azotifigens_A0A5C6VB62 Gammaproteobacteria-bacterium-SG8_A0A0S7YWC6 Acinetobacter-sp-CIP-7018_N9RB94Acinetobacter-sp-WC-141_K8ZWT1 Paraburkholderia-caribensis_A0A142Z0Q0 Verrucomicrobia-bacterium_A0A2V6J2T6 Caballeronia-catudaia_A0A158BGT7 Acinetobacter-sp-CIP-562_N8WCY5 Acidobacteria-bacterium_A0A2V8S5N5 Novimethylophilus-kurashikiensis_A0A2R5F1Z2 Serratia-sp-S1B_A0A2V1H7Z0Acinetobacter-tandoii_A0A5N4W5M9 Paraburkholderia-hospita_A0A244DQM5 Aeromonas-sp-YN13HZO-058_A0A1Q8CZL3 Acinetobacter-sp-COS3_U7H256Acinetobacter-sp-JW_A0A372BHZ3 Caballeronia-temeraria_A0A158A4W1 Mycobacterium-lepraemurium_A0A250BQ52

Chamaesiphon-minutus-strain-ATCC-27169_K9UEF8 Acinetobacter-seifertii_N8QUJ7 Chthoniobacter-flavus-Ellin428_B4DBB1 Psychrobacter-sp-ANT_H59_A0A5B0B8Q7 Paraburkholderia-steynii_A0A4V2NGA1 Burkholderia-sp-YR290_A0A2C9AT55 Paraburkholderia-sp-DCY113_A0A5B0G8H0 Caballeronia-fortuita_A0A158C7C4 Betaproteobacteria-bacterium-HGW-Betaproteobacteria-11_A0A2N2UTY2Psychrobacter-sp-P11G5_A0A127GYU8 Paraburkholderia-susongensis_A0A1X7J343 Psychrobacter-sp-P11G5_A0A127H315 Psychrobacter-urativorans_A0A0M4T4C9 mine-drainage-metagenome_A0A1J5QXA7 Paraburkholderia-terrae_A0A2I8ER65 mine-drainage-metagenome_A0A1J5RDM1mine-drainage-metagenome_A0A1J5RFZ6 Caballeronia-calidae_A0A158D3L4 marine-sediment-metagenome_A0A0F9RSG6 Herbaspirillum-robiniae_A0A246WMS3Caballeronia-glebae_A0A158C318Caballeronia-arvi_A0A158KFF2 Psychrobacter-sp-ANT_A0A5A9ZDC7Psychrobacter-sp-15012011_F5SRR9 Caballeronia-glathei_A0A069PJQ6Caballeronia-hypogeia_A0A158CQ07

Pandoraea-sp-LMG-31011_A0A5E4UGD3

Thiobacillus-sp-SCN-64-317_A0A1E4PV86 Rhodanobacter-fulvus-Jip2_I4VK49Caballeronia-pedi_A0A158CDI6 Colwellia-sp-OISW-25_A0A5S3PU79 Aeromonas-hydrophila_A0A3T0ZWN9 Pandoraea-norimbergensis_A0A0U2MD30 Candidatus-Paraburkholderia-sp-4M-K11_A0A4R5M7D9 Hydrogenovibrio-marinus_A0A066ZMH0 Herbaspirillum-sp-meg3_A0A223PAK5 Pandoraea-sp-LMG-31110_A0A5E4UWX1Pandoraea-sp-LMG-31009_A0A5E4S7V6 Aeromonas-sp-RU34C_A0A1N6TN03 Pandoraea-sp-LMG-31110_A0A5E4XK84Pandoraea-sp-LMG-31114_A0A5E4V457 Aeromonas-sp-A35_A0A261DZ10 Deinococcus-sp-H1_A0A553UE58 Pandoraea-sp-LMG-31009_A0A5E4RYL0 Aeromonas-hydrophila_A0A4P7IPD8Aeromonas-sobria_A0A1S2CYD9 Pandoraea-terrae_A0A5E4S829 Pandoraea-sp-LMG-20603_A0A5E5BQI9Pandoraea-sp-LMG-31012_A0A5E4Y7T2 Gammaproteobacteria-bacterium-39-13_A0A1Q3SWE6Aeromonas-sp-HMWF017_A0A2R7NEG4 Pandoraea-pulmonicola_A0A378Z096Pandoraea-sp-LMG-31013_A0A5E4RFY6 Pseudomonas-pohangensis_A0A1H2EJD9Azotobacter-beijerinckii_A0A1H6Y1U9Legionella-sainthelensi_A0A447SW73Legionella-sainthelensi_A0A0W0YBF9 Pandoraea-sp-LMG-31106_A0A5E4RFB3 Hydrogenophilales-bacterium-17-64-34_A0A259FEJ9Azotobacter-beijerinckii_A0A1H6SUH7Azotobacter-beijerinckii_A0A1H9IH18 Pandoraea-sp-LMG-20602_A0A5E4SRU4 Aeromonas-sp-CA23_A0A291U1R1 Pandoraea-sp-LMG-31010_A0A5E4RHV7 Aeromonas-dhakensis_K1JA78Aeromonas-jandaei_A0A3N6Y6V2Aeromonas-jandaei_A0A2S5FH81 Herbaspirillum-sp-CF444_J3DB03

Burkholderia-sp-DHOD12_A0A4P8IYF8 Thiobacillus-sp-63-78_A0A1Q4GEL5 Aeromonas-sp-L_A0A0D0QKL1 Thiorhodococcus-drewsii-AZ1_G2E778 Hydrogenophilales-bacterium-12-61-10_A0A257XYU0 Pandoraea-pnomenusa_A0A518R100Pandoraea-pnomenusa_A0A378YYP2 Aeromonas-sobria_A0A2N3IWH6Aeromonas-jandaei_A0A3N6UVP3 Pandoraea-sp-64-18_A0A1Q4CAC5 Marisediminitalea-aggregata_A0A1M5NE08

Burkholderia-gladioli-strain-BSR3_F2LKV7 Pandoraea-pnomenusa_A0A518R2V6 Paraburkholderia-sp-CNPSo-3008_A0A4R5LM93Deltaproteobacteria-bacterium_A0A2E9R5E7Polynucleobacter-sp-35-46-207_A0A258QXD1Rhizobium-phaseoli_A0A2U3CLE3Aeromonas-caviae_A0A3G9IEG5 Methylotenera-versatilis-strain-301_D7DP58 Burkholderia-sp-SJZ115_A0A560UNQ5Oxalobacteraceae-bacterium-CAVE-383_A0A4Q2IZW7 Pandoraea-apista_A0A0G4JMQ5 Pandoraea-apista_A0A5E5PCW5 Paraburkholderia-eburnea_A0A2S4M7G8Paraburkholderia-silvatlantica_A0A2U1AMI2 Frateuria-terrea_A0A1H6ZJY7 Pandoraea-apista_A0A427J1W4 Paraburkholderia-tropica_A0A1H7DRJ4 Cupriavidus-basilensis-OR16_H1SBP5 Colwellia-sp-Arc7-D_A0A2S0UZ75 Methylophilaceae-bacterium-17-43-7_A0A259A1M2 Polynucleobacter-sp-35-46-11_A0A258M7N5 marine-sediment-metagenome_A0A0F9RX74 Paraburkholderia-tropica_A0A1A5XF47 Trinickia-sp-7GSK02_A0A4U1I007 Paraburkholderia-sprentiae-WSM5005_A0A1I9YUE5 Methylophilales-bacterium-16-45-9_A0A258SSE1 Paraburkholderia-sacchari_A0A0A6QEI1Paraburkholderia-sp-7MH5_A0A4P7CXN1Burkholderia-sp-SRS-W-2-2016_A0A1Q8IW67Legionella-sp-km772_A0A3S0XEG8Burkholderiaceae-bacterium-16_A0A0F0FE77Sulfuricella-denitrificans-strain-DSM-22764_S6AJK9 Pandoraea-sp-SD6-2_R7X0L9 Burkholderia-gladioli_A0A3G3LA22Burkholderia-gladioli_A0A2A7SDN9Burkholderia-gladioli_A0A095GEB7 Sideroxydans-lithotrophicus-strain-ES-1_D5CRI6Dokdonella-immobilis_A0A1I4X7P8 Colwellia-chukchiensis_A0A1H7KDY9 Geobacter-metallireducens-strain-GS-15_Q39XU3 Pseudoalteromonas-phenolica_A0A5R9Q1B7 Burkholderiales-bacterium-28-67-8_A0A258R7I5Cupriavidus-basilensis_A0A0C4Y2G7 Stenotrophomonas-humi_A0A0R0C2K4 Robbsia-sp-DHC34_A0A494XYX1Burkholderia-plantarii_A0A0B6RT74 Sulfuriferula-sp-AH1_A0A1Y0G7C2 Pandoraea-apista_A0A5E5PA06 Stenotrophomonas-acidaminiphila_A0A2L0SNY1 Paraburkholderia-sp-DHOA04_A0A3N6NZT4Paraburkholderia-unamae_A0A328XZJ5Burkholderia-sp-TNe-862_A0A1G6PZR8mine-drainage-metagenome_A0A1J5S4K1Cupriavidus-metallidurans_A0A132HFV9 Paraglaciecola-psychrophila-170_M4RS21 Burkholderia-sp-strain-CCGE1002_D5WMH6Thiobacillus-sp-SCN-63-57_A0A1E4NY05Cupriavidus-metallidurans_A0A482J0V4mine-drainage-metagenome_A0A1J5TM73Verrucomicrobia-bacterium_A0A3E1E1R5 Paraburkholderia-xenovorans-strain-LB400_Q143F9Cupriavidus-sp-USMAA2-4_A0A1D9H4G2Paraburkholderia-sp-UYCP14C_A0A4Q6WYS2Collimonas-fungivorans-strain-Ter331_G0ABU8 Actinoplanes-sp-strain-ATCC-31044_G8SD88Actinoplanes-sp-strain-ATCC-31044_G8S7S9 Shewanella-mangrovi_A0A094LNL7 Paraburkholderia-phenoliruptrix-BR3459a_K0DZ08Methylotenera-versatilis-strain-301_D7DJG3mine-drainage-metagenome_A0A1J5S534 Thermomonas-fusca_A0A5R9PIM3 Xanthomonadaceae-bacterium-SCN-69-123_A0A1E4KQ54 Abditibacterium-utsteinense_A0A2S8SS74 Mycobacterium-avium-subsp-hominissuis_A0A3B6X7X4Mycobacterium-avium-subsp-hominissuis_A0A5A4W9U2Mycobacterium-avium-subsp-avium-2285-R_X8BCN1 Shewanella-fodinae_A0A4R2FHF6 Mycobacterium-avium-XTB13-223_A0A049DC15 Stenotrophomonas-acidaminiphila_A0A0R0DPX4 Mycobacterium-avium-subsp-hominissuis_A0A2A3LBY4 Stenotrophomonas-acidaminiphila_A0A0S1B2S6 Methylobacterium-sp-yr596_A0A1I2HFW3 Mycobacterium-avium-subsp-hominissuis-A5_A0A0E2W500Mycobacterium-avium-subsp-avium-11-4751_V7LCF7Mycobacterium-avium-subsp-hominissuis_A0A4P8UN50 Paraburkholderia-tuberum_A0A1H1KDW6uncultured-bacterium-UPO50_A0A126SYA6Thiobacillus-sp-0-1251_A0A1Q4EMX9 Lysobacter-enzymogenes_A0A1H3EA20 Methylobacterium-aquaticum_A0A0C6FV27Methylobacterium-currus_A0A2R4WRY2

Lysobacter-sp-yr284_A0A1H3MT01

Stenotrophomonas-sp-Leaf70_A0A0Q4QWY0 Lysobacter-enzymogenes_A0A1J1EFA7 Acidocella-aminolytica-101-=-DSM-11237_A0A0D6PLK2Paraburkholderia-sp-BL9I2N2_A0A4R1LZ42Massilia-yuzhufengensis_A0A1I1RCL8 Gallaecimonas-pentaromativorans_A0A3N1PJ14 Methylobacterium-radiotolerans_A0A438LLH1Leifsonia-xyli_A0A2W5TRS2 Mycobacterium-sp-852002-10029_A0A1A1W9N3 Paraburkholderia-aromaticivorans_A0A248VUJ4Gallionellaceae-bacterium_A0A521Q539Geobacter-sp-FeAm09_A0A5C1M8W2 Lysobacter-enzymogenes_A0A3N2RPH2 Methylobacterium-sp-XJLW_A0A2U9TN03 Prokaryotes-Bacteria-Chloroflexi_Ktedonobacter-racemifer-DSM-44963_D6TSY7 Stenotrophomonas-terrae_A0A0R0CHU7 Paraburkholderia-phenazinium_A0A1G7SJW0Paraburkholderia-fungorum_A0A2N8QGY4mine-drainage-metagenome_A0A1J5RG77 Stenotrophomonas-sp-KCTC-12332_A0A126NQE7 Methylobacterium-sp-UNCCL125_A0A1I7K5P2 Paraburkholderia-phenazinium_A0A4R7QGY3Paraburkholderia-monticola_A0A149PGD0Sutterellaceae-bacterium_A0A2E2R3D2Rhodoferax-sp-CHu59-6-5_A0A515DH60 Blastomonas-natatoria_A0A2V3UNN5 Paraburkholderia-phenazinium_A0A1N6JQ95 Methylorubrum-populi-strain-ATCC-BAA-705_B1ZCG9 Burkholderia-sp-WAC0059_A0A2J6MVP9Paraburkholderia-phenazinium_A0A1N6JMH1Paraburkholderia-strydomiana_A0A4R0X115Sulfurirhabdus-autotrophica_A0A4R3YEW2 Lysobacter-lycopersici_A0A516V854 Mycobacterium-sp-12451111_A0A1A3PLD4 Burkholderia-sp-Leaf177_A0A0Q5NZQ8Cupriavidus-sp-SK-3_A0A069ID01 Paraglaciecola-polaris-LMG-21857_K6Z913 Paraburkholderia-sartisoli_A0A1H4HCN1 Stenotrophomonas-sp-ATCM1_A0A4R4IIZ2 Oleiagrimonas-sp-MCCC-1A03011_A0A328SVA1 Mycobacterium-colombiense_A0A1R0USI1Mycobacterium-colombiense-CECT-3035_J4TE44 Paraburkholderia-megapolitana_A0A1I3D7G0Burkholderia-sp-OK233_A0A2C9C2D5 Lysobacter-silvestris_A0A2K1Q284 Mycobacterium-vulneris_A0A1X2L752Mycobacterium-colombiense_A0A1A0V6X5Mycobacterium-tuberculosis-TKK-01-0051_A0A051U360Mycobacterium-sp-E2479_A0A1A2S7I5Mycobacterium-sp-852002-40037_A0A1B7UCP8 Paraburkholderia-sp-DHOC27_A0A372JZE4Caballeronia-sordidicola_A0A242M4G8Cupriavidus-sp-HMR-1_L2E867 bacterium-SCN-62-11_A0A1E4FQ00Mycobacterium-colombiense_A0A1A2YEN2Mycobacterium-colombiense_A0A1A3S7I3Mycobacterium-colombiense_A0A1A2S9D0Mycobacterium-mantenii_A0A1X0FXV8Mycobacterium-mantenii_A0A1A2SU32Mycobacterium-sp-14822926_A0A1A3EJJ6Mycobacterium-colombiense_A0A329KWH6 Paraglaciecola-arctica-BSs20135_K6YL29 Paraburkholderia-caledonica_A0A2Z5MK33Paraburkholderia-insulsa_A0A2T1ABH5Paralcaligenes-ureilyticus_A0A4R3M659 Lysobacter-dokdonensis-DS-58_A0A0A2X264 Methylobacterium-dankookense_A0A564FZW6 Paraburkholderia-sp-OV446_A0A2V3R7F1Rugosibacter-aromaticivorans_A0A0C5J6J7Deltaproteobacteria-bacterium_A0A534VFZ6 Mycobacterium-sp-E1214_A0A1A2KHM9Mycobacterium-sp-14657030_A0A1A3DHA9Mycobacterium-sp-852002-51971_A0A1A2AZX4Mycobacterium-colombiense_A0A329L9T7 Xanthomonadaceae-bacterium_A0A4V2BG78 Methylobacterium-sp-GXS13_A0A0V7Z5W8 Paraburkholderia-caribensis_A0A2T3Y978Caballeronia-sordidicola_A0A158G615Geobacter-sp-Red88_A0A5A9XE51mine-drainage-metagenome_A0A1J5RF20mine-drainage-metagenome_A0A1J5TBD9 marine-sediment-metagenome_A0A0F9KLX6

Lysobacter-sp-UKS-15_A0A5D8Z6U8 Shewanella-putrefaciens_A0A3S4PBT6 Mycobacterium-paragordonae_A0A386TZL1Mycobacterium-paragordonae_A0A4R5WYW0 Shewanella-putrefaciens_A0A379ZTE3 Methylobacterium-sp-WL1_A0A5B9EY87Comamonadaceae-bacterium_A0A4Q3PHB1 Erythrobacter-sp-HN-E23_A0A3N5CVV0 Limnobacter-sp-MED105_A6GPB2Collimonas-fungivorans_A0A127PBM4 Shewanella-baltica-strain-OS223_B8E3K0 Erythrobacteraceae-bacterium_A0A2E0Q2M9 Collimonas-fungivorans_A0A419TYF4 Thermomonas-sp-SY21_A0A5B7ZUK9 Methylobacterium-sp-GXS13_A0A0V7Z9I4 Polaromonas-sp-C04_A0A1S8FW85Sulfuricella-sp-T08_A0A0E9MED1 Stenotrophomonas-pictorum-JCM-9942_A0A0R0ANB3 Pistricoccus-aurantiacus_A0A5B8SQT9Collimonas-pratensis_A0A127Q3L5Collimonas-sp-OK242_A0A1H3ADZ5Collimonas-sp-OK607_A0A1I0V635Sideroxydans-sp-CL21_A0A5Q4ZH23 Burkholderiales-bacterium_A0A431J619 Hyphomonas-beringensis_A0A062U3Z8 Paraburkholderia-lacunae_A0A370NAU2Burkholderia-sp-yr520_A0A329DGX0Caballeronia-terrestris_A0A158K591Fibrobacteres-bacterium_A0A3C0PI47Collimonas-sp-PA-H2_A0A2A9JT95Collimonas-pratensis_A0A127R0A7Collimonas-sp-OK412_A0A1I1DPV5 Mycobacterium-sp-E342_A0A1A2PQI4Mycobacterium-gordonae_A0A0Q2XIW1 Pseudomonas-acidophila_A0A2A4EP68 Lysobacter-sp-TY2-98_A0A345ZHG6 Mycobacterium-simiae_A0A1X0Y9B8 Collimonas-sp-OK307_A0A1I3IFX3 Lysobacter-sp-A03_A0A0D0RWL4 Mycobacterium-sp-10819081_A0A1A3QEC4Mycobacterium-paraseoulense_A0A1X0I5J6Mycobacterium-scrofulaceum_A0A1X0K8T4Mycobacterium-szulgai_A0A1X2EMM4Mycobacterium-shigaense_A0A1Z4ENB4 Bradyrhizobium-erythrophlei_A0A1M7U9K7 Methylobacterium-sp-UNC378MF_A0A1G5T7B0 Mycobacterium-sp-852014-50255_A0A1A0U448Mycobacterium-europaeum_A0A0U1DTA2Mycobacterium-malmoense_A0A1B9CJ11 Burkholderia-sp-WP9_A0A1H5L1H0Collimonas-arenae_A0A561GM71 Mycobacterium-sp-12458059_A0A1A3CVK6Mycobacterium-sp-ACS4054_A0A1A1WMD7Mycobacterium-sp-E2733_A0A1A2USV4Mycobacterium-sp-E1386_A0A1A2XQD9Mycobacterium-sp-852014-52450_A0A1A2DGV4Mycobacterium-scrofulaceum_A0A1A2UZR7Mycobacterium-sp-E3247_A0A1A2N2E7 Hyphomonas-jannaschiana-VP2_A0A059FHL8 Enhydrobacter-aerosaccus_A0A1T4SRB1Burkholderia-sp-CCGE1001_E8YT40Caballeronia-choica_A0A158J019Enhydrobacter-aerosaccus_A0A1T4SBU7 Mycobacterium-sp-E2327_A0A1A2X563Mycobacterium-paraffinicum_A0A1Q4HZ68Mycobacterium-sp-E1715_A0A1A2PFD2Mycobacterium-sp-E3339_A0A1A2JJQ2Mycobacterium-angelicum_A0A1W9ZVD8Mycobacterium-sp-11000297_A0A1A0KDG5Methylobacterium-sp-P1-11_A0A5A7ZYI4 Lysobacter-ruishenii_A0A562LI55 Novosphingobium-malaysiense_A0A0B1ZMV8 Mycobacterium-nebraskense_A0A0F5N825Mycobacterium-parmense_A0A1X2ATJ1Mycobacterium-sp-AB215_A0A2U3PDZ1Mycobacterium-sp-AB57_A0A2U3NSW8Methylobacterium-sp-UNC378MF_A0A1G5T9P0Hyphomonas-sp-CY54-11-8_A0A059DRS0Hyphomonas-adhaerens_A0A3B9GZL3Novosphingobium-sp-PASSN1_A0A257G9R4Sphingomonas-glacialis_A0A502G0N7 Prokaryotes-Bacteria-Nitrospiraceae_Leptospirillum-ferriphilum_A0A094X678 Mycobacterium-sp-E796_A0A1A2ZXZ9Mycobacterium-sp-15544247_A0A1A0LUF4Hyphomonas-adhaerens-MHS-3_A0A069E0B6Novosphingobium-sediminis_A0A512AQV9 Caballeronia-humi_A0A158GNQ0Collimonas-arenae_A0A0A1FC71 Methylobacterium-radiotolerans_A0A3S3AYR2 Novosphingobium-sp-16-62-11_A0A258Y2H4Novosphingobium-sp-28-62-57_A0A258UW01Caulobacter-sp-BK020_A0A4R3GL05 Mycobacterium-sp-SP-6446_A0A1R0UAE1Mycobacterium-conspicuum_A0A1X1TCR0 Novosphingobium-sediminis_A0A512ALJ6 Burkholderia-insecticola_R4X1V2 Prokaryotes-Bacteria-Nitrospiraceae_Leptospirillum-ferriphilum-YSK_A0A059XQY1Prokaryotes-Bacteria-Nitrospiraceae_Leptospirillum-sp-Group-II-CF-1_A0A0K0WPG3 Sphingomonas-sp-TDK1_A0A196N8H7 Achromobacter-aloeverae_A0A4Q1HQL3 Novosphingobium-aromaticivorans-strain-ATCC-700278_Q2G4N5 Prokaryotes-Bacteria-Nitrospiraceae_Leptospirillum-ferriphilum_A0A1V3SX70 Mycobacterium-sp-IEC1808_A0A1X2DIE4Mycobacterium-triplex_A0A024JPF2Sphingomonas-sp-TDK1_A0A196N723Novosphingobium-sp-PASSN1_A0A257G5Y8Novosphingobium-aromaticivorans-strain-ATCC-700278_Q2GBR8 Mycobacterium-sp-IS-2888_A0A1R0VKG2 Altererythrobacter-sp-FM1_A0A3N2QMW7Novosphingobium-fuchskuhlense_A0A117UXM7 Mycobacterium-bohemicum-DSM-44277_A0A0U0WAL0Mycobacterium-florentinum_A0A1X1U437 Rhizobiales-bacterium-GAS191_A0A1H5PHA3 Methylobacterium-sp-WL6_A0A5C8WQX9 IsArctic_Ga0401205_2200227Sphingopyxis-macrogoltabida_A0A0P0DVC2Aestuariisphingobium-litorale_A0A419MS91 Acidocella-sp-20-63-7_A0A257NP46 Methylobacterium-sp-WL12_A0A5C8SP91Propionibacteriaceae-bacterium_A0A4V2AR32 Mycobacterium-ahvazicum_A0A2K4YHX6Mycobacterium-lentiflavum_A0A0E4H172Novosphingobium-kunmingense_A0A2N0HJ92 Bradyrhizobium-betae_A0A4Q1UR81Bradyrhizobium-erythrophlei_A0A1M7U554 Methylobacterium-sp-WL1_A0A5B9EX94 Mycobacterium-noviomagense_A0A1X0GDC0Mycobacterium-sp-E787_A0A1A2ZZE6 Bordetella-genomosp-11_A0A261US52 Sphingopyxis-sp-MG_A0A2L0VVW2 Burkholderia-sp-Ch1-1_I2IPL1 Pyrenophora-tritici-repentis_A0A2W1D2E8 Mycobacterium-paraense_A0A1X2ABA5Mycobacterium-interjectum_A0A1X1WY73 Bradyrhizobium-lablabi_A0A2H9V562 Candidatus-Nucleicultrix-amoebiphila-FS5_A0A1W6N334 Burkholderiaceae-bacterium_A0A522GCY9 Mycobacterium-sp-AB308_A0A2U3N8I8Methylobacterium-sp-GXS13_A0A0V7Z9M7Phenylobacterium-zucineum_A0A227JP36Alphaproteobacteria-bacterium-HGW-Alphaproteobacteria-14_A0A2N3D607 Tardiphaga-sp-vice352_A0A515KGQ5 Lysobacter-oculi_A0A344J446 Methylobacterium-sp-WL1_A0A5B9F4Z9Novosphingobium-tardaugens-NBRC-16725_U2YP40 Bradyrhizobiaceae-bacterium_A0A431NWV1Bradyrhizobium-lablabi_A0A1M6YRB4 Burkholderiales-bacterium_A0A3S0EKX4 Methylobacterium-sp-GXS13_A0A0V7Z5W5 Novosphingobium-sp-FSW06-99_A0A117V139 Rhodopseudomonas-palustris_A0A0D7E1Y7 Burkholderiales-bacterium_A0A431KL06 Sphingomonas-sp-IC081_A0A514WP51 Aquabacterium-sp-NJ1_A0A0A0DQ76 Mycobacterium-sp-E3198_A0A1A2HI53Erythrobacter-sp-SAORIC-644_A0A2K1E2N5 Mycobacterium-palustre_A0A1X1ZTE6Erythrobacteraceae-bacterium_A0A2D9PD59Sphingomonas-sp-HMF7854_A0A3R9X994Sphingomonas-sp-FARSPH_A0A345WTY1Novosphingobium-sp-Leaf2_A0A0Q4CBF3Novosphingobium-mathurense_A0A1U6HLD0Novosphingobium-sp-PP1Y_F6IK77Novosphingobium-pentaromativorans-US6-1_G6EE58 Beijerinckiaceae-bacterium_A0A2N8MCT9Bradyrhizobiaceae-bacterium_A0A431P9U5 Herbaspirillum-sp-GW103_I3CVH4 Methylobacterium-radiotolerans_A0A3S3B209Erythrobacter-xanthus_A0A3A1PF06Novosphingobium-barchaimii-LL02_A0A0J7XGV5Novosphingobium-sp-KN652_A0A158S1L7 Acidocella-sp-20-57-95_A0A257Q3K3Bradyrhizobium-canariense_A0A1H1UI29Acetobacteraceae-bacterium_A0A354V6H9 Rhodanobacter-sp-Root179_A0A0Q8M219 Herbaspirillum-seropedicae_A0A5B8E507Herbaspirillum-sp-VT-16-41_A0A1V2VAM7 Alphaproteobacteria-bacterium-PA2_A0A257J904 Herbaspirillum-aquaticum_A0A225SWR8 Methylobacterium-sp-17SD2-17_A0A2U8WA91Methylobacterium-radiotolerans_A0A3S3ASJ1Bradyrhizobium-manausense_A0A0R3CT95Erythrobacter-sp-SG61-1L_A0A0P6WIW1 Bradyrhizobium-erythrophlei_A0A1M5X4B8 Massilia-sp-Root1485_A0A0Q7XWH2 Sphingomonas-sp-Leaf339_A0A0Q6L217 Afipia-sp-GAS231_A0A1H0H2B1 Rhodoplanes-sp-Z2-YC6860_A0A127EX58Methylobacterium-sp-yr596_A0A1I2HDC2Methylobacterium-aquaticum_A0A0C6G0W5Methylobacterium-currus_A0A2R4WS02 Sinobacteraceae-bacterium_A0A5C7L699 Methylobacterium-brachiatum_A0A3G2V8C9Bradyrhizobium-guangzhouense_A0A4Q0RJM4Caulobacter-rhizosphaerae_A0A561MML6Sphingopyxis-sp-MC1_N9W1C3Sphingopyxis-sp-65-8_A0A1Q3UXZ6Sphingopyxis-sp-A083_A0A0W1IF66 Massilia-sp-Root335_A0A0Q6SAY7 Bradyrhizobium-sp-strain-ORS-278_A4YXN7Bradyrhizobium-sp-MOS003_A0A2T2Q328Bradyrhizobium-elkanii_A0A0D1M003Rhodopseudomonas-palustris_A0A0D7EVA8Methylobacterium-sp-GXF4_I9CL59Bradyrhizobium-japonicum_A0A0A3YRJ0Bradyrhizobium-sp-Gha_A0A1I3LNL5Bradyrhizobium-guangdongense_A0A410VGS5Sphingopyxis-terrae-subsp-terrae-NBRC-15098_A0A142W202Sphingopyxis-terrae-subsp-ummariensis_A0A1Y6FTU1 Bradyrhizobium-lablabi_A0A1M7G649Bradyrhizobium-sp-STM-3809_H0T3B3 Methylobacterium-sp-ARG-1_A0A0L6J9T4Methylobacterium-sp-ARG-1_A0A0L6JEB2Methylobacterium-sp-XJLW_A0A2U9TT62Bradyrhizobium-japonicum_A0A1L3FHX0 Afipia-sp-Root123D2_A0A0Q6Z8M2Massilia-sp-WF1_A0A0J1DA99 Methylobacterium-dankookense_A0A564G0J3Bradyrhizobium-arachidis_A0A1I7KZ98Bradyrhizobium-sp-Ghvi_A0A1I5GIK4 Bradyrhizobiaceae-bacterium-PARB1_A0A257KGI8 Bradyrhizobium-japonicum_A0A1Y2JDI8Bradyrhizobium-sp-G22_A0A160UZL2Bradyrhizobium-cytisi_A0A5S4WP53 Bradyrhizobium-sp-LTSP885_A0A0D7P7X9Rhodospirillales-bacterium-69-11_A0A1Q3V7Y9Bradyrhizobium-rifense_A0A5D3KLN0Bradyrhizobium-neotropicale_A0A176ZIN4Sphingomonas-sp-PP-CE-3A-406_A0A3M0FW86Sphingomonas-sp-Leaf198_A0A0Q5UK82 Candidatus-Melainabacteria-bacterium_A0A317IHI3 Sphingomonas-sp-Leaf242_A0A0Q4QTK0Sphingomonas-sp-PP-CC-3G-468_A0A4R1U145 Bradyrhizobium-sp-WSM471_H5YJC2Bradyrhizobium-sp-LTSPM299_A0A0D7QGJ3Tistlia-consotensis-USBA-355_A0A1Y6CTA0 Caulobacter-sp-FWC2_A0A2G5QLN2Sphingomonas-sp-PP-CE-1A-559_A0A4R2SN27 Bordetella-genomosp-10_A0A261S0W0 Sphingomonas-sp-PP-CE-1G-424_A0A4R2S1V9Sphingomonas-sp-Leaf230_A0A0Q4IHA7Sphingomonas-faeni_A0A2T5TW01 Bradyrhizobium-sp-Leo121_A0A4Q7G4P5Bradyrhizobium-sp-NAS962_A0A1Q5RQD1Bradyrhizobium-macuxiense_A0A560LY40Bradyrhizobium-sp-C9_A0A2A6NSP2Defluviimonas-sp-20V17_A0A059IQ84 Bradyrhizobium-centrolobii_A0A176YB93Caulobacter-sp-Root342_A0A0Q6TWP4Sphingomonas-sp-PP-F2F-G114-C0414_A0A3M0EH76 Extensimonas-vulgaris_A0A369AMD4 Bradyrhizobium-erythrophlei_A0A1H5FAF4Bradyrhizobium-erythrophlei_A0A1M5UYP9 Sphingomonas-wittichii-strain-RW1_A5V2B1 Rhodospirillales-bacterium_A0A522V227 Bradyrhizobium-sp-UFLA03-84_A0A2A2VIT4 Eoetvoesia-caeni_A0A366H726Xylella-fastidiosa-32_A0A1S0V9V9 Pseudolabrys-taiwanensis_A0A345ZTK0 Ralstonia-sp-SET104_A0A401K106 Bradyrhizobium-sp-SK17_A0A2K8Y6B4Bradyrhizobium-sp-STM-3843_H0TPN1Bradyrhizobium-erythrophlei_A0A1M5HSI8 Sphingomonas-sp-EC-SD391_A0A5E7YL83 Oxalobacteraceae-bacterium-IMCC9480_F1VWR2Burkholderiales-bacterium-67-32_A0A1Q3XIP2 Bradyrhizobium-sp-Leo170_A0A4Q8QW46Bradyrhizobium-elkanii_A0A0D1LWD4Bradyrhizobium-lablabi_A0A1M7AN06 Afipia-broomeae_A0A2M8ZCY3 Bradyrhizobiaceae-bacterium-PARB1_A0A257KT23Beijerinckiaceae-bacterium_A0A522GEB6 Rhizobiales-bacterium_A0A2W6A524 Ralstonia-pickettii-strain-12D_C6BL21 Sphingorhabdus-soli_A0A5C6U481Sphingomonas-sp-AAP5_A0A4P6X605 Ralstonia-sp-A12_A0A0B1YBC3Paraburkholderia-terricola_A0A1M6WQU8 Variovorax-sp-EL159_A0A1G4ZTT5 Rhizobiales-bacterium_A0A3C0BTL7Alphaproteobacteria-bacterium_A0A537Q4J9 Alphaproteobacteria-bacterium_A0A537MIP2 Nitrobacter-sp-62-13_A0A1Q3JW82Methylocella-tundrae_A0A4U8YW48 Bradyrhizobium-retamae_A0A0R3MDX3 Rhizobiales-bacterium-65-79_A0A1M2Z1M8 Cupriavidus-sp-USMAA2-4_A0A1D9GYZ3 Caulobacter-sp-strain-K31_B0SZN3 Massilia-sp-ONC3_A0A4Y9SRT2Achromobacter-spanius_A0A3S9Z427 Ralstonia-sp-5_U3G7E6 Sphingomonas-sp-YZ-8_A0A494T5H0 Beijerinckiaceae-bacterium_A0A4P7F2X8 Chloracidobacterium-sp-CP2_A0A257B041 Dyella-sp-4G-K06_A0A370X5D9 Pusillimonas-sp-ANT_A0A5A9X842Alcaligenaceae-bacterium-SAGV5_A0A5N7RW60 Bradyrhizobium-erythrophlei_A0A1M5R040Bradyrhizobium-sp-STM-3843_H0TNP3 Janthinobacterium-sp-TND4EL3_A0A1N6Y704Janthinobacterium-sp-ROICE36_A0A2N6ICT8 Sphingobium-sp-AEW013_A0A560WU82 Ralstonia-pickettii-strain-12D_C6BKS1 Simplicispira-sp-NY-02_A0A398C706Ralstonia-pickettii_A0A1C0XFP4 Methylovirgula-ligni_A0A3D9Z4T3 Sphingomonas-sp-FARSPH_A0A345WU93 Rhodocyclaceae-bacterium_A0A3S0GCD7Cupriavidus-metallidurans_A0A132HAD2Duganella-sacchari_A0A1M7KR91 Acetobacteraceae-bacterium-DB1506_A0A327LVA6Rhizobiales-bacterium_A0A353YDA6 Novosphingobium-sp-28-62-57_A0A258UWH0 Acidovorax-caeni_A0A1I7KR20 Ralstonia-mannitolilytica_A0A2N5L895Desulfocarbo-indianensis_A0A0K9I293 Hymenobacter-nivis_A0A2Z3GU66 Bradyrhizobium-sp-Leaf396_A0A0Q5ZDW0Methyloligella-halotolerans_A0A1E2RWE2Sphingomonas-sp-AAP5_A0A4P6XF74 Azotobacter-beijerinckii_A0A1H6Z9U2Paraburkholderia-rhynchosiae_A0A2N7WVV0Caballeronia-catudaia_A0A158DLM2Burkholderia-cenocepacia-strain-ATCC-BAA-245--DSM-16553--LMG-16656--NCTC-13227--J2315--CF5610_B4E762 Sphingomonas-sp-28-66-16_A0A258TI22 Dechloromonas-aromatica-strain-RCB_Q47DP6 Bradyrhizobium-sp-35-63-5_A0A258JGM9Sphingobium-cupriresistens_A0A4Q4JKM2 Janthinobacterium-lividum_A0A1S1TZX4Variovorax-paradoxus_A0A192XE47Delftia-lacustris_A0A1H3N582 Tibeticola-sediminis_A0A3N4UZK0Comamonas-thiooxydans_A0A0E3BVD0 Hyphomonas-johnsonii-MHS-2_A0A059FTS5Sphingomonas-sp-Leaf357_A0A0Q5RER4 Rubrivivax-sp-SCN-70-15_A0A1E4PU50 Sphingomonas-sp-EC-HK361_A0A5E7YAA5Novosphingobium-sp-32-60-15_A0A258HSG2Novosphingobium-sp-P6W_A0A2Z5EA20 Candidatus-Accumulibacter-sp-66-26_A0A1Q3VW99 Sphingobium-sp-EO9_A0A418YN01Sphingobium-sp-strain-NBRC-103272_G2IU90Sphingobium-francense_A0A4Q4IY57Sphingomonas-sp-PP-F2F-A104-K0414_A0A4R2T8Q7 Candidatus-Accumulibacter-aalborgensis_A0A1A8XQT0 Sphingomonas-rubra_A0A1I5URZ6 Janthinobacterium-sp-ROICE36_A0A2N6IBT9Eoetvoesia-caeni_A0A366H125 Brevundimonas-diminuta_A0A410NWJ1 Janthinobacterium-sp-67_A0A2M8XU61Cupriavidus-necator_A0A1U9USY5 Hyphomonadaceae-bacterium-BRH_c29_A0A0F2QGC7Sphingomonas-sp-TDK1_A0A196NC40Sphingomonas-sp-PP-CC-3A-396_A0A4R2TSU1 Afipia-felis_A0A380W5Y0 Bradyrhizobium-erythrophlei_A0A1N6G9A8Rhizobiales-bacterium-64-17_A0A1Q4DBZ8 Novosphingobium-sp-GV013_A0A4R7D3I5Phenylobacterium-sp-SCN-70-31_A0A1E4GP08 Cupriavidus-lacunae_A0A370NTW3 Beijerinckiaceae-bacterium-RH-AL1_A0A5E4P0N7 Brevundimonas-diminuta_A0A1Z3LZV4Sphingomonas-sp-67-36_A0A1M3DEL3 Hymenobacter-nivis_A0A2Z3H0N3 Nitrobacter-hamburgensis-strain-DSM-10229_Q1QPJ8Aerococcus-urinae_A0A329P6H4 alpha-proteobacterium-U9-1i_A0A1V1PTF9 Hymenobacter-sp-PAMC-26554_A0A142HH38 Sphingomonas-sp-YR710_A0A1G6HZ83 Afipia-felis_A0A090MG32Rhizobiales-bacterium-62-47_A0A1Q4BSJ6 Rhodobacterales-bacterium-12-64-8_A0A257Y8C2 Phenylobacterium-sp-Root700_A0A0Q8LXL8 Afipia-sp-1NLS2_D6V1K1 Sphingomonas-sp-67-41_A0A1Q4E353Sphingomonas-sp-28-62-20_A0A258SCA0 Sphingomonas-sp-IBVSS2_A0A1Y2QRJ3 Dankookia-rubra_A0A4R5QAY2 Tardiphaga-robiniae_A0A163XPP6 Paraburkholderia-caballeronis_A0A1H7RKD9Burkholderia-dabaoshanensis_A0A2N7VIT9 Trinickia-soli_A0A2N7WFX3 Bradyrhizobiaceae-bacterium_A0A431RUA0 Paraburkholderia-sp-T12-10_A0A5A7X9Z6 Afipia-broomeae-ATCC-49717_K8PKM3 Paraburkholderia-rhizosphaerae_A0A4R8LWF7Trinickia-symbiotica_A0A2T3Y0F9Trinickia-symbiotica_A0A2N7WVK5 Bradyrhizobiaceae-bacterium_A0A3S0E2K5 Paraburkholderia-sp-PDC91_A0A2W7F9Z1Paraburkholderia-sp-SOS3_A0A1L6IAE6 Paracraurococcus-sp-NE82_A0A4R4DME2 Paraburkholderia-sp-7MK8-2_A0A494XJ00Chlorobaculum-tepidum-strain-ATCC-49652_Q8KFX3Chlorobaculum-parvum-strain-NCIB-8327_B3QQM8

Proteobacteria-bacterium_A0A4Q6ATQ9

Burkholderia-sp-OK233_A0A2C8ZYW7 Bdellovibrio-sp-qaytius_A0A3T0RWI3 Deltaproteobacteria-bacterium_A0A534UFJ5 Caballeronia-mineralivorans-PML112_A0A0J1CYW9Oxalobacteraceae-bacterium-OM1_A0A4Y9RNC8 Phenylobacterium-sp-LX32_A0A328AJQ1Caballeronia-udeis_A0A3M0UJJ8Acidobacteria-bacterium_A0A2V8NUM8 Rhodopila-globiformis_A0A2S6N788Armatimonadetes-bacterium-55-13_A0A1Q3MG99Acidobacteria-bacterium_A0A2V8S968Leptolyngbya-sp-NIES-2104_A0A0P4UXR1 Deltaproteobacteria-bacterium_A0A534XTR1 Deltaproteobacteria-bacterium_A0A534PVG7 Desulfovibrio-fructosivorans-JJ_E1JWW6Gemmatimonadetes-bacterium_A0A2V7JT07

Verrucomicrobia-bacterium_A0A2V5VEK7 Verrucomicrobia-bacterium_A0A2V5SF95 Spartobacteria-bacterium_A0A3B9LBT1

Brevundimonas-sp-GW460-12-10-14-LB2_A0A160I1W9Brevundimonas-sp-Leaf280_A0A0S9NSU9 Caulobacteraceae-bacterium_A0A4Q3U2P1

Hyphomonadaceae-bacterium_A0A3D3Z4X4 Pseudoxanthomonas-sp-NML140781_A0A4Q8LJI2Pseudoxanthomonas-sp-NML130969_A0A4Q8M303Pseudoxanthomonas-sp-NML171590_A0A4Q9TGS2Pseudoxanthomonas-sp-NML171200_A0A4Q8LAF3 Pseudoxanthomonas-sp-NML171202_A0A4Q8L8S5 Prokaryotes-Bacteria-Chloroflexi_Chloroflexi-bacterium_A0A536EAH1 Pseudoxanthomonas-sp-GM95_A0A1H7XT53 Prokaryotes-Bacteria-Chloroflexi_Chloroflexi-bacterium_A0A535B9W7 Brevundimonas-subvibrioides_A0A258HP09 Stenotrophomonas-sp-LMG-10879_A0A2G7RSM1Ralstonia-solanacearum-CMR15_D8N3J0Brevundimonas-subvibrioides_A0A258FJJ9 Prokaryotes-Bacteria-Chloroflexi_Chloroflexi-bacterium_A0A536LS77 Stenotrophomonas-maltophilia_A0A431UB71Stenotrophomonas-maltophilia_A0A4T1GYD0Stenotrophomonas-maltophilia_A0A5K7XRL4Stenotrophomonas-sp-CC120222-04_A0A239QDK1Stenotrophomonas-maltophilia-Ab55555_J7VG28Ralstonia-solanacearum_A0A1Y0FDR5Ralstonia-solanacearum_A0A0S4WZZ3Ralstonia-solanacearum_A0A347DVW3Ralstonia-solanacearum_A0A0S4TRV5Ralstonia-solanacearum_A0A0S4WNC8Ralstonia-solanacearum-FQY_M4UZP5Ralstonia-solanacearum_A0A5B7U7W9Hyphomonas-chukchiensis_A0A062UMK8Xanthomonas-theicola_A0A2S6ZEM8 Stenotrophomonas-maltophilia_A0A2J0U9Q7Mesorhizobium-sp-M00FCaET1700111_A0A4S0VPF1Stenotrophomonas-sp-SKA14_B8L1N8Stenotrophomonas-sp-Nf4_A0A2T3X162Stenotrophomonas-maltophilia_A0A427CSL0Stenotrophomonas-maltophilia_A0A2W6ISF6Stenotrophomonas-sp-CC22-02_A0A4R7UJ76Stenotrophomonas-maltophilia-strain-K279a_B2FNT2Stenotrophomonas-maltophilia_A0A2J0T0M2Stenotrophomonas-sp-AG209_A0A397M6A8Stenotrophomonas-maltophilia_A0A0R0B1F2Stenotrophomonas-maltophilia_A0A4Z0DKA1Stenotrophomonas-pavanii_A0A246KU54Stenotrophomonas-maltophilia_A0A0M1F4J9Stenotrophomonas-maltophilia_A0A5K1NNU3Ralstonia-solanacearum-strain-Po82_F6G4S7Ralstonia-solanacearum_A0A1C0UJY9blood-disease-bacterium-A2_A0A1U9VHI1Ralstonia-syzygii-R24_G3A326Xanthomonas-campestris-pv-translucens_A0A561PF81Flaviaesturariibacter-sp-17J68-12_A0A4R1B514Flavobacterium-sp-BFFFF1_A0A257K3C8 Stenotrophomonas-maltophilia_A0A0K2IJA6Stenotrophomonas-maltophilia_A0A2W6ISW3Stenotrophomonas-maltophilia_A0A317C3F5Stenotrophomonas-maltophilia_A0A2Y9UC74Stenotrophomonas-maltophilia_A0A4S1MAZ5Stenotrophomonas-maltophilia_A0A2Z3YAR6Stenotrophomonas-maltophilia_A0A2J0SXV4Stenotrophomonas-maltophilia_A0A1V3CXJ6Stenotrophomonas-maltophilia_A0A0M0NMM9Burkholderiaceae-bacterium-26_A0A0F0DFC7Ralstonia-solanacearum_A0A399W0Z6Xanthomonas-sp-NCPPB-1128_A0A0J6IUA1 (ii) Scrippsiella and Geminigera Ralstonia-sp-NFACC01_A0A1I5UHZ6Xanthomonas-sacchari_A0A0A8DZ45Xanthomonas-sacchari_A0A5D1ABV7 Xanthomonas-sacchari_A0A2P5Z4T8Flavobacterium-sp-140616W15_A0A3G2GHU6 Methylococcaceae-bacterium_A0A4P5W5U1Ralstonia-sp-A12_A0A0B1YJW2Ralstonia-sp-AU12-08_S9RSZ0Ralstonia-insidiosa_A0A192A1I6Rhodospirillaceae-bacterium_A0A2E6QJG7 Methylococcales-bacterium_A0A3A2J507Burkholderiales-bacterium_A0A431KD48Ralstonia-sp-MD27_A0A0J9DMM5Flavobacterium-psychrolimnae_A0A366AYH9 Methylococcaceae-bacterium-NSM2-1_A0A257N0U5Planctomycetes-bacterium-GWC2_A0A1G2X8T8Alphaproteobacteria-bacterium-HGW-Alphaproteobacteria-12_A0A2N3EK84Flavisolibacter-ginsengisoli-DSM-18119_A0A1M5DL75 Abditibacterium-utsteinense_A0A2S8SNS6Flavisolibacter-tropicus_A0A172TVF8Hymenobacter-sp-PAMC-26628_A0A126PGG3Rickettsiaceae-bacterium_A0A4Q3DGD1Hymenobacter-sp-92R-1_A0A4Z0P6Z5Flavobacterium-sp-GT3P67_A0A4R5FF39Flavobacteriales-bacterium-32-34-25_A0A258JY52 Hymenobacter-sp-YR204_A0A495UXQ7Hymenobacter-perfusus_A0A428KJW4Flavobacterium-sp-123_A0A495SJA4Arcticibacter-svalbardensis-MN12-7_R9GMS0 Hymenobacter-persicinus_A0A4Q5LAW3 Dyadobacter-sp-AR-3-6_A0A4R5DR44Bacteroidetes-bacterium-GWF2_A0A1F3KDF1 Hymenobacter-psychrophilus_A0A1H3BAY4Hymenobacter-sp-92R-1_A0A4Z0NYF2Hymenobacter-wooponensis_A0A4Z0MD59Flavihumibacter-sp-ZG627_A0A0C1L2A2 Hymenobacter-actinosclerus_A0A1I0BR10Spirosoma-sordidisoli_A0A4Q2UEI3Cytophagaceae-bacterium_A0A4Q3QRF7Hymenobacter-persicinus_A0A4V1ZB84Spirosoma-pollinicola_A0A2K8Z688 Hymenobacter-sp-UV11_A0A4Z0ESP3 Arachidicoccus-sp-KIS59-12_A0A386HMD5 Hymenobacter-sp-Fur1_A0A558BKK8 Aequorivita-sublithincola-strain-DSM-14238_I3Z056 Hymenobacter-amundsenii_A0A246FG91Hymenobacter-rubripertinctus_A0A418QPR2 Flavobacterium-sp-AR-3-4_A0A4R5CGA1 Sphingomonas-oligophenolica_A0A502CET7 Burkholderia-singularis_A0A238GYS1Burkholderia-pseudomallei-strain-668_A3N6P3Burkholderia-pseudomallei_A0A3B6WHB8Burkholderia-sp-TSV86_A0A124PCX6Burkholderia-pseudomallei-strain-1026b_A0A0H3HQP7Burkholderia-pseudomallei-strain-K96243_Q63WI7Burkholderia-sp-lig30_A0A063BCM6 Burkholderia-sp-MSMB617WGS_A0A1B4SAQ7Burkholderia-sp-ABCPW-14_A0A132C5G6Burkholderia-thailandensis_A0A291CK25Burkholderia-oklahomensis_A0A381BW47Burkholderia-sp-BDU6_A0A1B4FBW6Burkholderia-singularis_A0A103DWA0Burkholderia-pseudomallei-MSHR4000_A0A0F6L6F0Burkholderia-sp-MSMB1552_A0A104M2F8Burkholderia-pseudomallei-1710a_A0A0E1W340Burkholderia-pseudomallei-576_A0A0E1UB77Burkholderia-pseudomallei-S13_B1HF01Burkholderia-thailandensis-strain-ATCC-700388--DSM-13276--CIP-106301--E264_Q2T0H7Burkholderia-thailandensis_A0A2N8QZ43Pseudomonas-punonensis_A0A1M7NDI0Pseudomonas-argentinensis_A0A1I3KSN8 marine-sediment-metagenome_A0A0F9K2F8 Burkholderia-multivorans-CGD2_B9BR70Burkholderia-pseudomultivorans_A0A132EYD0Burkholderia-cenocepacia_A0A088UXW7Burkholderia-multivorans_A0A1W0ZML3Burkholderia-sp-TJI49_F0G3B8Burkholderia-multivorans-CF2_J5B485Burkholderia-vietnamiensis_A0A2Z6TCB8 Sphingomonas-sp-AAP5_A0A4P6X8K0 Burkholderia-lata-strain-ATCC-17760--DSM-23089--LMG-22485--NCIMB-9086--R18194--383_A0A3G3H6P5Burkholderia-stabilis_A0A4Q2AQB9Burkholderia-catarinensis_A0A1J9PVK8Burkholderia-cepacia_A0A0J5VM15Burkholderia-stabilis_A0A1Y1BHA7Burkholderia-pyrrocinia_A0A4R4FM50Burkholderia-pyrrocinia_A0A2Z5MXK5Burkholderia-pyrrocinia_A0A0G3WKJ5Burkholderia-cepacia_A0A3N8S3C7Burkholderia-sp-AU17325_A0A228IUD9Burkholderia-sp-LS-044_A0A4S5CYF1Burkholderia-cepacia_A0A103WJI9Burkholderia-cepacia_A0A1Z3YWJ4Burkholderia-cepacia_A0A118KMJ7Burkholderia-pyrrocinia_A0A087P155Burkholderia-stabilis_A0A498RSG2Burkholderia-pyrrocinia_A0A318IM05Burkholderia-stabilis_A0A1D7ZGJ9Burkholderia-cenocepacia_A0A071MJB5Burkholderia-cepacia_A0A2S8J142Burkholderia-sp-JP2-270_A0A2U9SI08Burkholderia-sp-28_A0A364GYL1Burkholderia-ubonensis_A0A3N7RNT5Burkholderia-ubonensis_A0A103RCY4Burkholderia-ubonensis_A0A105JFK6Burkholderia-ubonensis_A0A117X921Burkholderia-ubonensis_A0A107GAD2Burkholderia-ubonensis_A0A118XAB6Burkholderia-ubonensis_A0A108CAI1Burkholderia-ubonensis_A0A124RGF9Pseudomonas-mesoacidophila_A0A2A4FGU3Burkholderia-vietnamiensis_A0A132DX33Burkholderia-vietnamiensis_A0A103HUT9Burkholderia-ubonensis_A0A1B4LGA7Pseudomonas-sp-RW407_A0A2V2SW54Pseudomonas-straminea_A0A1I1ULF0 Gulosibacter-molinativorax_A0A2P7AHD1 Burkholderia-puraquae_A0A1X1PCW4Burkholderia-contaminans_A0A1E3FRN8Burkholderia-sp-AU6039_A0A228PNA9Burkholderia-seminalis_A0A118FPT0Burkholderia-sp-HI2714_A0A228R4B8Burkholderia-lata-strain-ATCC-17760--DSM-23089--LMG-22485--NCIMB-9086--R18194--383_Q39DM4Burkholderia-cepacia-JBK9_A0A0U4D6N1Burkholderia-sp-Bp8992_A0A3N8H496Burkholderia-sp-NFACC38-1_A0A1I0LLW8Burkholderia-cenocepacia-strain-ATCC-BAA-245--DSM-16553--LMG-16656--NCTC-13227--J2315--CF5610_B4E901Burkholderia-cepacia_A0A1B4PUL9Burkholderia-cenocepacia_A0A2N9CKB8Burkholderia-cepacia_A0A095DR79Burkholderia-cenocepacia_A0A3Q9F842Pseudomonas-indica_A0A1G9F5C1Pseudomonas-fulva-strain-12-X_F6AKA8Pseudomonas-sp-AG1028_A0A561D7F4 Actinobacteria-bacterium_A0A538KFA4 Burkholderia-sp-MSMB1835_A0A118LJ30Burkholderia-cepacia_A0A095GSJ6Burkholderia-cenocepacia-strain-MC0-3_B1JXC7Burkholderia-cenocepacia_A0A427P4F6Burkholderia-cenocepacia_A0A3N9GEI3Burkholderia-metallica_A0A1B4HW89Burkholderia-latens_A0A1B4NU14Burkholderia-sp-IDO3_A0A2A4CHM6Burkholderia-ambifaria-MEX-5_B1T8S1Burkholderia-ambifaria-strain-MC40-6_B1YVA8Burkholderia-sp-Nafp24-1b_A0A495YL99Burkholderia-ambifaria-IOP40-10_B1F9Z3Burkholderia-sp-Bp9031_A0A3P0MYE0Burkholderia-sp-Bp9017_A0A3P0P6S2 Actinobacteria-bacterium_A0A538KHS5Actinobacteria-bacterium_A0A538CU35 Burkholderia-diffusa_A0A1B4BUE9Burkholderia-sp-USM-B20_A0A4R9MGV4Burkholderia-sp-Bp9004_A0A3P0SSH5Burkholderia-cepacia-GG4_J7IZT2Burkholderia-territorii_A0A104CUN0Burkholderia-sp-LA-2-3-30-S1-D2_A0A1B4F0L2Burkholderia-sp-Bp8998_A0A3N8I7Y1Burkholderia-sp-Bp9142_A0A3N8ASV5Burkholderia-sp-FL-7-2-10-S1-D7_A0A118G3Q6Burkholderia-sp-Bp8963_A0A3N8M3Z4Burkholderia-sp-Bp9143_A0A3N8AP61Burkholderia-sp-Bp9126_A0A3N8CFR5Pseudomonas-mendocina_A0A379IXD0 Colwellia-sp-OISW-25_A0A5S3P2B4 Burkholderia-sp-SRS-46_A0A4R4CJX8Burkholderia-pyrrocinia_A0A104NKN2Burkholderia-stagnalis_A0A107ZU96Burkholderia-sp-Bp9125_A0A3N8BCT9Burkholderia-stagnalis_A0A3P0EQA6 Baekduia-soli_A0A5B8U1Z3 Pseudomonas-sp-J237_A0A1E5XDP0Pseudomonadaceae-bacterium_A0A2D5CDU1 Aurantimonas-manganoxydans-strain-ATCC-BAA-1229_Q1YL11 Pseudomonas-guineae_A0A1I3ERA5Pseudomonas-lundensis_A0A266N5X5Pseudomonas-fragi_A0A2T0IKP8Pseudomonas-fragi_A0A267CGF2 Pseudomonas-taeanensis-MS-3_A0A0A1YDT6Pseudomonas-leptonychotis_A0A4T2A2U4Pseudomonas-sp-TCU-HL1_A0A1B3EAQ2Pseudomonas-fragi_A0A109R7K5Pseudomonas-versuta_A0A0M3UDB9Pseudomonas-sp-PAMC-29040_A0A433XV31Pseudomonas-sp-Lz4W_A0A2H4VWX9Pseudomonas-lundensis_A0A1D9IIN6Pseudomonas-saxonica_A0A5C5PVJ0Pseudomonas-fragi_A0A266LRT4Pseudomonas-fragi_A0A267A6W6Pseudomonas-sp-TMW-21634_A0A494R8D2 Pseudomonas-sp-SJZ079_A0A560Q346Rhizobium-sp-SLBN-4_A0A542V0Z7Pseudomonas-sp-FeS53a_A0A0D6T1T0Pseudomonas-deceptionensis_A0A0J6GIG0 Rhodobacteraceae-bacterium-PARR1_A0A257F1E0 Pseudomonas-sp-ANT_A0A5B0FWY5Pseudomonas-sp-OV529_A0A2V5AN34Pseudomonas-frederiksbergensis_A0A291AMN8Pseudomonas-sp-GM18_J2NZ48Pseudomonas-frederiksbergensis_A0A2S8HG15Pseudomonas-sp-ES3-33_A0A0D9AB02Pseudomonas-sp-LAB-08_A0A1B4WSJ0Pseudomonas-arsenicoxydans_A0A4P6GAA7Pseudomonas-arsenicoxydans_A0A1H0T172 Pseudomonas-chlororaphis_A0A423DLG3Pseudomonas-sp-MF4836_A0A1T1HU61Pseudomonas-frederiksbergensis_A0A423KEV3Pseudomonas-sp-GM50_J3AHM5Pseudomonas-sp-Root329_A0A0Q6R3M0Pseudomonas-putida_A0A2Z4RJ44Pseudomonas-fluorescens_A0A0F4SR05Pseudomonas-sp-ACM7_A0A4V0YL61Pseudomonas-arsenicoxydans_A0A502HWJ8Pseudomonas-sp-F01002_A0A4Y8JF85Pseudomonas-sp-GR-6-02_A0A173JDY5Pseudomonas-sp-ok266_A0A1H8H1L0Pseudomonas-sp-ERMR1_A0A270PJX5Pseudomonas-sp-URMO17WK12_A0A2W7J8Z2Pseudomonas-sp-MPR-ANC1_A0A2K4I8B2Pseudomonas-sp-DTU123_A0A481R019Pseudomonas-sp-OV657_A0A3D9XZT4Pseudomonas-vancouverensis_A0A1H2P8K9Pseudomonas-fluorescens_A0A423P736Pseudomonas-sp-W15Feb9B_A0A0C2MCD4Pseudomonas-sp-GV091_A0A2T5VRM4Pseudomonas-fluorescens_A0A5E6XK34Pseudomonas-fluorescens_A0A423LSN3Pseudomonas-parafulva_A0A497UEF1Pseudomonas-chlororaphis_A0A0A6D8P3Pseudomonas-moraviensis_A0A2A2PQS6Pseudomonas-fluorescens_A0A4P7I9R2Pseudomonas-koreensis_A0A436ZJL7Pseudomonas-fluorescens_A0A423MJ01Pseudomonas-sp-GM30_W6VNF6Pseudomonas-fluorescens_A0A2A5RFE9Pseudomonas-putida_A0A1G6B8Z6Pseudomonas-sp-91RF_A0A399PVK9Pseudomonas-fluorescens_A0A345V1L9Pseudomonas-sp-DR-5-09_A0A173J9I1Pseudomonas-fluorescens_A0A0C2ACC2Pseudomonas-sp-AD21_A0A2N7RGD6Pseudomonas-sp-HMWF021_A0A2R7NES2Pseudomonas-kribbensis_A0A345RV18Pseudomonas-kribbensis_A0A4Y8VDQ2Pseudomonas-sp-CH235_A0A5E9IAR2Pseudomonas-sp-GM25_J3EZY1Pseudomonas-sp-ICMP22404_A0A5C4PHH3Pseudomonas-sp-43mfcvi11_A0A2V1Y2F7Pseudomonas-brassicacearum_A0A423GGF5Pseudomonas-sp-SHC52_A0A0A1HR52Pseudomonas-sp-SJZ078_A0A560PVH1Pseudomonas-fluorescens-Q2-87_J2Y9A7Pseudomonas-mediterranea-CFBP-5447_A0A0A4GIP7Pseudomonas-sp-NFACC16-2_A0A1K1RUK7Pseudomonas-sp-NFACC15-1_A0A1G5ZKS8 Mesorhizobium-ciceri-biovar-biserrulae-strain-HAMBI-2942--LMG-23838--WSM1271_E8THQ9Prokaryotes-Archaea-Euryarcheota_Methanosarcina-lacustris-Z-7289_A0A0E3S3Q5Actinobacteria-bacterium_A0A538KFX3 Pseudomonas-sp-GV071_A0A2T5H660Pseudomonas-sp-OV467_A0A2V5AFZ2Pseudomonas-sp-MRSN12121_A0A0C5EQK8Pseudomonas-chlororaphis_A0A0D5XVP1Pseudomonas-fluorescens-strain-Pf0-1_Q3K7Q7 Nostoc-sp-Peltigera-membranacea-cyanobiont-210A_A0A235IJ23 Pseudomonas-sp-HMWF005_A0A2R7TAZ3Pseudomonas-sp-HMWF007_A0A2R7RMQ4Pseudomonas-sp-GW531-R1_A0A2K4J5S9Pseudomonas-kairouanensis_A0A4Z0ARS4Pseudomonas-nabeulensis_A0A4Z0B936Pseudomonas-sp-ICMP-564_A0A2G0WED5Pseudomonas-poae_A0A2S9EXZ9Pseudomonas-sp-KBW05_A0A3N7CJH7Pseudomonas-sp-2822-17_A0A2G5MZN9Pseudomonas-sp-OV577_A0A3D9W4H2Pseudomonas-marginalis-pv-marginalis_A0A3M5PSP4Pseudomonas-sp-22-E-5_A0A1B5F2M1Pseudomonas-sp-CFBP13506_A0A4U3D3L6Pseudomonas-sp-2995-3_A0A2G5NBJ8Pseudomonas-marginalis-pv-marginalis_A0A3M4FA92Pseudomonas-fluorescens_A0A0W0I795Pseudomonas-marginalis-ICMP-9505_A0A0W0LUK7Pseudomonas-salomonii_A0A3M4QRJ5Pseudomonas-sp-FH4_W2D934Pseudomonas-fluorescens_A0A379IHZ8Pseudomonas-fluorescens_A0A379JCT1Pseudomonas-brenneri_A0A4R6YXM8Pseudomonas-sp-ICMP-8385_A0A2G0ZAE7 Hydrogenovibrio-marinus_A0A5A4WGU7Hydrogenovibrio-marinus_A0A066ZTB5Nostoc-sp-Peltigera-membranacea-cyanobiont-232_A0A235ITS1Nostoc-sp-Peltigera-membranacea-cyanobiont-232_A0A235JAD2 Pseudomonas-fluorescens-WH6_E2XXF5Pseudomonas-sp-R4-35-07_A0A3G8AMI7Pseudomonas-fluorescens_A0A1T2Y0E9Pseudomonas-sp-RIT357_A0A031IQ79Pseudomonas-panacis_A0A5M9IGV3Pseudomonas-sp-GV047_A0A2T6LYS7Pseudomonas-sp-Leaf98_A0A327GGK3Pseudomonas-costantinii_A0A1S2V421Pseudomonas-sp-LBUM920_A0A3G8D6Y5Pseudomonas-antarctica_A0A1G9XSH8Pseudomonas-sp-IB20_A0A263NN34Pseudomonas-sp-KBS0710_A0A554T9Q0Pseudomonas-sp-BCA17_A0A5R1QFA9Pseudomonas-antarctica_A0A172Z722Pseudomonas-sp-RGB_A0A558FSF1Pseudomonas-fluorescens_A0A1T3AF04Pseudomonas-sp-OV286_A0A2V5B5L1Pseudomonas-sp-NFPP04_A0A1I3I718Pseudomonas-palleroniana_A0A2L1JAL8Pseudomonas-azotoformans_A0A1V2JSA4Pseudomonas-salomonii_A0A1H3T3Y2Pseudomonas-libanensis_A0A0R2YBP1Pseudomonas-sp-S09G-359_A0A2K9CMR4 Rhodobacteraceae-bacterium_A0A2D5IYP5 Chamaesiphon-polymorphus-CCALA-037_A0A2T1G8G9 Pseudomonas-sp-PGPPP1_A0A257DV28Pseudomonas-sp-1-R-17_A0A1C3GTM0Pseudomonas-sp-FDAARGOS_A0A292D475Pseudomonas-sp-KG01_A0A0J8FZ93Pseudomonas-sp-MF6394_A0A1T1IS82Pseudomonas-sp-R937_A0A2P8LD42Pseudomonas-sp-OV546_A0A1I7JKA5Pseudomonas-fluorescens-strain-SBW25_C3K169Pseudomonas-sp-ANT_A0A5B0BYN2Pseudomonas-sp-URMO17WK12_A0A1X7EJ61Pseudomonas-sp-CC120222-01a_A0A315T1X0Pseudomonas-sp-382_A0A2G8MU56Pseudomonas-putida_A0A2W5MIR0 Rhodobacteraceae-bacterium_A0A2K9JWB5 Nostoc-punctiforme-strain-ATCC-29133--PCC-73102_B2JBI4Nostoc-punctiforme-strain-ATCC-29133--PCC-73102_B2IW26 Pseudomonas-sp-R5-89-07_A0A3G7YGJ2Pseudomonas-sp-SXM-1_A0A4P7AY01Pseudomonas-yamanorum_A0A143GCK7Pseudomonas-sp-K2I15_A0A246FY54Pseudomonas-fluorescens_A0A109KQN7Pseudomonas-sp-CFSAN084952_A0A5Q2IYN6Pseudomonas-sp-AP42_A0A1E4UZH3Pseudomonas-sp-OV184_A0A4V3DBZ3Pseudomonas-lactis_I4K494Rhodobacteraceae-bacterium-PD-2_A0A0B4FJL4Pseudomonas-veronii_A0A5M8E1A6Pseudomonas-extremaustralis_A0A5M9IPF7Pseudomonas-sp-GV105_A0A2T6LM79Pseudomonas-extremaustralis_A0A5C5QG97Pseudomonas-sp-FW507-12TSA_A0A2K4J8I6Pseudomonas-sp-CMR5c_A0A3G7A5H0Pseudomonas-mosselii_A0A5R8Z349Pseudomonas-putida_A0A0P7CK78Pseudomonas-entomophila-strain-L48_Q1I5Q5Pseudomonas-sp-250J_A0A0L6FYM9Pseudomonas-sp-RIT623_A0A4Y8SS77Pseudomonas-sp-Leaf58_A0A0Q4N156Pseudomonas-mosselii_A0A290HFD8Pseudomonas-sp-AFG_A0A368AP02Pseudomonas-sp-PONIH3_A0A2L0LQS5Pseudomonas-putida_A0A2D1TB61Pseudomonas-putida_A0A0P7D670Pseudomonas-sp-CCOS-191_A0A0F7YAS8Pseudomonas-hunanensis_A0A2I0CJU0Pseudomonas-sp-KU43P_A0A5K7U0F2Pseudomonas-putida_A0A427QBB0Pseudomonas-plecoglossicida-NB2011_S2KLP3Pseudomonas-putida_A0A1X1A6B7Pseudomonas-putida_A0A4D6XAA1Pseudomonas-putida_A0A2S3WWU6Pseudomonas-sp-SWI6_A0A2L1HQ35 Gemmobacter-sp-HYN0069_A0A2S0UQQ5 Chamaesiphon-minutus-strain-ATCC-27169_K9UDW5Lysobacter-sp-UKS-15_A0A5D8Z4R3 Pseudomonas-saponiphila_A0A1H4KEJ9Pseudomonas-sp-TKO29_A0A2W0FTG2Pseudomonas-sp-MWU12-2534b_A0A365VVX3Pseudomonas-sp-Os17_A0A0D6BNC4Pseudomonas-protegens_A0A2T6GIW4Pseudomonas-sp-HLS-6_A0A2D2MAL8Pseudomonas-sp-22015_A0A0F0F5R8Pseudomonas-sp-FFUP_A0A2N5BQU9Pseudomonas-sp-CMR12a_A0A3G7API0Pseudomonas-sp-SDI_A0A315WTI1Pseudomonas-alkylphenolica_A0A443ZSH8Pseudomonas-putida_A0A1B2F6W8Pseudomonas-putida_A0A1L5PV98Pseudomonas-plecoglossicida_A0A099N5Q9Pseudomonas-sp-JV551A1_A0A446A361Pseudomonas-putida_A0A3M8R674Pseudomonas-putida_A0A1S2JSH5Pseudomonas-guariconensis_A0A1G6SFV6Pseudomonas-sp-LAIL14HWK12_A0A285YJL9Pseudomonas-putida_A0A1Y3KPB7Pseudomonas-monteilii_A0A3G2HKW0Pseudomonas-monteilii_A0A2L2KSM0Pseudomonas-putida_A0A1L7NIY1Pseudomonas-putida-H8234_R9VI50Pseudomonas-sp-JY-Q_A0A173HAV6 Rhizobium-leguminosarum-bv-trifolii_A0A3E1B8R8Rhizobium-leguminosarum-bv-trifolii-WSM597_J0H1I2 Mesorhizobium-sp-UASWS1009_A0A1C2E129 Pseudomonas-fluorescens-strain-ATCC-BAA-477--NRRL-B-23932--Pf-5_Q4K797Pseudomonas-protegens-strain-DSM-19095--LMG-27888--CHA0_A0A2C9ESC7Pseudomonas-sp-NFPP09_A0A1K1WA93Pseudomonas-sp-FW305-25_A0A2N8BIZ3Pseudomonas-chlororaphis-subsp-aurantiaca_A0A1E1G2B5Pseudomonas-chlororaphis-subsp-piscium_A0A3G7EUT3Pseudomonas-sp-NFACC41-3_A0A1H7P6J4Pseudomonas-chlororaphis_A0A1Q8ELY5Pseudomonas-putida_A0A1Q9RBT0Pseudomonas-japonica_A0A239A7F7Pseudomonas-putida_A0A177SLJ5Pseudomonas-sp-URIL14HWK12_A0A285NZ82 Pseudomonas-sp-LTJR-52_A0A3G2N1S2Pseudomonas-stutzeri_A0A2N8SYX5 Paenibacillus-macquariensis-subsp-defensor_A0A167WJV4Thalassolituus-oleivorans-MIL-1_M5E0G6 Pseudomonas-sp-AU11447_A0A1B8VBC1Pseudomonas-nitroreducens_A0A239JP72Pseudomonas-syringae_A0A1C7YYG3Pseudomonas-sp-T_A0A1V9UCA9Pseudomonas-sp-LAM1902_A0A5R9QRY0Pseudomonas-panipatensis_A0A1G8JED1Pseudomonas-kuykendallii_A0A1H2V9A0Pseudomonas-nitroreducens_A0A246F7W2Pseudomonas-nitroreducens_A0A5R9AEY5Pseudomonas-sp-21_A0A0F0DKG9Pseudomonas-sp-ATCC-13867_M4WUK5Pseudomonas-sp-HPB0071_N2J126Pseudomonas-savastanoi-pv-phaseolicola_A0A3M4N1Q7Pseudomonas-sp-ICMP-3272_A0A0W0IQ57Pseudomonas-savastanoi-pv-phaseolicola_A0A3M3T107Pseudomonas-sp-ST1_A0A554GXJ0Pseudomonas-amygdali-pv-ulmi_A0A0Q0E9I7Pseudomonas-amygdali-pv-lachrymans_A0A3M3E5U6Pseudomonas-amygdali_A0A0P9KJF0Pseudomonas-amygdali-pv-morsprunorum_A0A3M3TNI9Pseudomonas-amygdali-pv-tabaci_A0A0Q0BQ28Pseudomonas-amygdali-pv-sesami_A0A0Q0AMD0Pseudomonas-amygdali-pv-lachrymans_A0A0P9UR83Pseudomonas-amygdali-pv-lachrymans_A0A3M5J9G5Pseudomonas-amygdali-pv-eriobotryae_A0A0P9Q3T6Pseudomonas-syringae-CC1557_W0MXF3Pseudomonas-amygdali-pv-morsprunorum_A0A2S4IIN8Pseudomonas-avellanae_A0A261WGM6Pseudomonas-syringae-pv-actinidiae_A0A454G8M5Pseudomonas-syringae-pv-theae_A0A0Q0EK62Pseudomonas-syringae-group-genomosp-3_A0A2S3TYB3Pseudomonas-syringae-pv-actinidiae-ICMP-18807_S6V7W3Pseudomonas-syringae-pv-ribicola_A0A3M2W4D9Pseudomonas-syringae-pv-viburni_A0A0Q0DH25Pseudomonas-syringae-pv-primulae_A0A3M5T9C5 Mesorhizobium-opportunistum-strain-LMG-24607--HAMBI-3007--WSM2075_F7YA72Donghicola-tyrosinivorans_A0A2T0WDQ5Rhizobium-leguminosarum-bv-trifolii_A0A3E1B4L6Thioclava-sp-L04-15_A0A1T2BYW5Rhizobium-leguminosarum-bv-trifolii_A0A3E1BYF3Parasporobacterium-paucivorans-DSM-15970_A0A1M6D164Chroococcidiopsis-thermalis-strain-PCC-7203_K9UA63Synechococcus-sp-strain-ATCC-27167_K9RXC7 Pseudomonas-sp-CFII64_S6GXW4Pseudomonas-abietaniphila_A0A1G8GVZ0Pseudomonas-taetrolens_A0A0J6GF08Pseudomonas-graminis_A0A4R7VG13Pseudomonas-sp-SJZ080_A0A560QK71Pseudomonas-sp-ICMP-561_A0A2G0W311Pseudomonas-syringae-pv-syringae_A0A2S4JD88Pseudomonas-viridiflava_A0A1Y6JFD6Pseudomonas-sp-43NM1_A0A2N1EBK3Pseudomonas-sp-StFLB209_A0A077LH15Pseudomonas-syringae-pv-maculicola_A0A3M3AGM8Pseudomonas-syringae-pv-maculicola_A0A3M3GEV2Pseudomonas-prosekii_A0A2U2D3P8Pseudomonas-oleovorans_A0A3D9E768Pseudomonas-poae_A0A1H0IC97Pseudomonas-psychrotolerans_A0A4Y5W220 Mesorhizobium-japonicum-strain-LMG-29417--CECT-9101--MAFF-303099_Q98E10Halomonadaceae-bacterium-T82-2_A0A139CBL7Rhodobacter-sphaeroides_A0A2W5S2T1Other_MATOU-v2_474592126 filamentous-cyanobacterium-Phorm-46_A0A2T1EB80filamentous-cyanobacterium-Phorm-6_A0A2T1G5M4 Thioclava-electrotropha_A0A1W9XPU2Bacillus-methanolicus-strain-MGA3--ATCC-53907_I3ECR0Hapalosiphonaceae-cyanobacterium-JJU2_A0A328IB59Microcystis-aeruginosa-PCC-9443_I4G501Gemmatimonadetes-bacterium_A0A2V7H7P3 Rhizobium-leguminosarum_A0A4Q8XP07Rhizobium-leguminosarum_A0A4V2IGR4Ochrobactrum-rhizosphaerae_A0A256FS60Haematobacter-massiliensis_A0A4P6S2C1marine-sediment-metagenome_A0A0F9RWD9 Gemmatimonadetes-bacterium_A0A2V7JFJ6 mine-drainage-metagenome_A0A1J5P6Q0Rhizobium-sp-SEMIA-4088_A0A5F1RZQ9Rhizobium-leguminosarum_A0A179BD58Rhizobium-leguminosarum_A0A444IIA8Thioclava-sp-DLFJ5-1_A0A1T2BEJ8Thioclava-sp-JM3_A0A254UHU9 Hydrococcus-rivularis-NIES-593_A0A1U7HCN2 Pseudomonas-corrugata_A0A3M3ELF4Pseudomonas-sp-PGPPP3_A0A257D1H5Pseudomonas-mohnii_A0A1H4NVR7Pseudomonas-moorei_A0A1H1G4M1Pseudomonas-sp-57B-090624_A0A2W1MUI5Pseudomonas-sp-FSL-W5-0299_A0A1S8GVK7Pseudomonas-sp-22-E-5_A0A1B5EM07Pseudomonas-sp-SXM-1_A0A4P7B3E2Pseudomonas-veronii_A0A0R3A4W4Pseudomonas-panacis_A0A1H4KXT6Pseudomonas-veronii-1YdBTEX2_A0A1D3K6S4 Mesorhizobium-australicum-strain-HAMBI-3006--LMG-24608--WSM2073_L0KFR1Rhodobacterales-bacterium-65-51_A0A1Q4CP38Yangia-sp-SAOS-153D_A0A2A3JXJ6Salipiger-aestuarii_A0A327YAT2Halomonas-taeanensis_A0A328XQ83Marinobacter-santoriniensis-NKSG1_M7DI56Rhizobium-sp-CIAT894_A0A1W6KW62Rhizobium-acidisoli_A0A0N1DG71 Chroococcidiopsis-sp-CCALA-051_A0A2P8QVV7Fulvimarina-manganoxydans_A0A1W2C488Bradyrhizobiaceae-bacterium_A0A431P9V5 Ochrobactrum-sp-LP_A0A4R7W8K8Rhizobium-tropici-CIAT-899_L0LPB4Rhizobium-grahamii_A0A370KGY9 Brevibacillus-choshinensis_A0A0Q3WPU1Jiella-endophytica_A0A4Y8RBH4 Mesorhizobium-sp-M7AFCaCA0040511_A0A436GYC3Mesorhizobium-sp-M7AFCaMR2450000_A0A4P1NML5Mesorhizobium-sp-M7AFCaET0270321_A0A436XBM2Mesorhizobium-sp-M7AFCaUS0100211_A0A434WQ78Rhodobacterales-bacterium-12-65-15_A0A257ZHW9Rhizobium-tropici-CIAT-899_L0LUV1Rhizobiales-bacterium_A0A431RCI5Rubellimicrobium-rubrum_A0A5C4MWR1Rhizobium-sp-Root708_A0A0Q8NWL9Rhizobiales-bacterium-65-79_A0A1M2Z1G7Paenibacillus-terrae-strain-HPL-003_G7VQZ8Nostocales-cyanobacterium-HT-58-2_A0A1Y0REL1Hydrococcus-rivularis-NIES-593_A0A1U7HSQ4Nostoc-punctiforme-NIES-2108_A0A367RVD8Gemmatimonadetes-bacterium_A0A3D4YNP6 Mesorhizobium-sp-M7ATCaTU0090131_A0A434IPA6Rhodobacterales-bacterium-17-64-5_A0A259D174Rhodobacter-maris_A0A285TLK2Yangia-pacifica_A0A1I6WGY8Hwanghaeicola-aestuarii_A0A2W7NII7Paenibacillus-macquariensis-subsp-defensor_A0A167XFY6Paenibacillus-macquariensis_A0A168CZQ6Trichococcus-patagoniensis_A0A2T5IA10Fulvimarina-endophytica_A0A371WYD7 Mesorhizobium-sp-M7AFCaUS0080311_A0A3S1MB50Mesorhizobium-sp-M7AFCaUS0110111_A0A434ZGR1Mesorhizobium-sp-M7AFCaUS0060111_A0A435TWQ9Rhizobium-acidisoli_A0A0N0LAS7Rhizobium-vallis_A0A3S0S9N4Rhizobium-sp-C5_A0A2A6J6T9Loktanella-atrilutea_A0A1M5CWC3Rhizobium-sp-CCGE-510_J5N554Paenibacillus-polymyxa-strain-E681_E0RKH2marine-sediment-metagenome_A0A0F9UCR2 Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199267086_Scrippsiella-hangoei-like-Strain-SHHI-4Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199216868_Scrippsiella-hangoei-like-Strain-SHHI-4 Mesorhizobium-sp-M7AFCaCA0011611_A0A436GTU6Rhizobium-phaseoli_A0A2U3CLJ9Paenibacillus-sp-RU15A_A0A498AR57Paenibacillus-sp-BIHB4019_A0A1B2DTG5Falsibacillus-sp-GY-10110_A0A3L7JN44Planktothrix-sp-PCC-11201_A0A1T4ZEQ8Nostoc-commune-NIES-4072_A0A2R5FFE0Thiothrix-lacustris_A0A1Y1QK63 IsArctic_MATOU-v2_1329192806Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199304328_Scrippsiella-hangoei-like-Strain-SHHI-4Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199230896_Scrippsiella-hangoei-like-Strain-SHHI-4Scrippsiella-hangoei-SHTV5_CAMPEP-0191918260_Scrippsiella-hangoei-SHTV5 Acetobacteraceae-bacterium-KEBCLARHB70R_A0A5R9J5L8 Mesorhizobium-sp-M7AFCaUS0060421_A0A436CY66Mesorhizobium-sp-M7AFCaCA0010911_A0A435PQK4Mesorhizobium-sp-M7AFCaUS0070111_A0A435TNS0Mesorhizobium-sp-M7AFCaCA0010821_A0A3S2C1R4Rhizobium-freirei-PRF-81_N6UEE0Rhizobium-sp-Pop5_K0VZN8 Bacillus-koreensis_A0A0M0L8H1Paenibacillus-sp-XY044_A0A259TM46Paenisporosarcina-sp-OV554_A0A2T6K0R9Aphanothece-sacrum-FPU1_A0A401INX5Pleurocapsa-sp-PCC-7327_K9T6D4 Scrippsiella-hangoei-SHTV5_CAMPEP-0191824602_Scrippsiella-hangoei-SHTV5Scrippsiella-hangoei-SHTV5_CAMPEP-0191915982_Scrippsiella-hangoei-SHTV5Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199288840_Scrippsiella-hangoei-like-Strain-SHHI-4Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199258712_Scrippsiella-hangoei-like-Strain-SHHI-4Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199270120_Scrippsiella-hangoei-like-Strain-SHHI-4Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199253434_Scrippsiella-hangoei-like-Strain-SHHI-4Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199249414_Scrippsiella-hangoei-like-Strain-SHHI-4Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199246584_Scrippsiella-hangoei-like-Strain-SHHI-4Caballeronia-udeis_A0A158I7J6Paraburkholderia-aspalathi_A0A1I6XZ48 Ephemeroptericola-cinctiostellae_A0A345D7S0 Mesorhizobium-sp-M7AFCaCA0011311_A0A435K5H3Mesorhizobium-sp-M7AFCaCA0020911_A0A3S1RUR9Mesorhizobium-sp-M7AFCaCA0010611_A0A436IFM0Mesorhizobium-sp-M7AFCaCA0010511_A0A435JKB5Mesorhizobium-sp-M7AFCaAU0020211_A0A3S2FJG6Mesorhizobium-sp-M8AFCaET2130111_A0A4S0RSD9Mesorhizobium-sp-M8AFCaET0590111_A0A434Y9B6Pseudorhodobacter-sp-PARRP1_A0A257GIC0Rhizobium-pisi_A0A3R9BND6Loktanella-salsilacus_A0A1I4II17Rhizobiaceae-bacterium_A0A522RDK9Paenibacillus-sp-VTT-E-133280_A0A264DHV6Bacillus-megaterium_A0A2A8VNM5Paenibacillus-selenitireducens_A0A1T2XHE4 Thalassiosira-pseudonana-genomic_Thalassiosira-pseudonana-genomic_263287 Candidatus-Rokubacteria-bacterium_A0A2V6PFI8Burkholderia-sp-D7_A0A2C9B983Beijerinckia-sp-28-YEA-48_A0A1H4N5L2Acidisarcina-polymorpha_A0A2Z5FXZ9Geobacter-sp-FeAm09_A0A5C1M8E8Dyella-sp-4G-K06_A0A370WZM4Granulicella-sibirica_A0A4Q0T6A6Acidisarcina-polymorpha_A0A2Z5GAU3Pleomorphomonas-carboxyditropha_A0A2G9WRV7Pleomorphomonas-sp-CF100_A0A4R8FHV4 Mesorhizobium-sp-M8AFCaET0230111_A0A434XUA4Mesorhizobium-sp-M00FCaET1510111_A0A5R2K9I8Rhizobium-sp-Root1203_A0A0Q6RMZ1Devosia-sp-67-54_A0A1Q3YXI4Loktanella-atrilutea_A0A1M5FU51Paenibacillus-riograndensis-SBR5_A0A0E3WH35Scopulibacillus-darangshiensis_A0A4R2NTM5Bacillus-sp-Root239_A0A0Q9HWP7Cohnella-sp-K2E09-144_A0A398CRP1Tolypothrix-sp-NIES-4075_A0A218QU64Bosea-sp-EC-HK365B_A0A5E8CAC5 IsArctic_MATOU-v2_1346224556IsArctic_MATOU-v2_1459467536IsArctic_MATOU-v2_1349839974 Polymorphobacter-sp-DJ1R-1_A0A4Y9EN08 Bradyrhizobium-lablabi_A0A1M6W889Bradyrhizobium-erythrophlei_A0A1M7U5C6Bradyrhizobium-erythrophlei_A0A1M5QYU3Bradyrhizobium-canariense_A0A1H1UJ68Bradyrhizobium-erythrophlei_A0A1N6FM53Afipia-broomeae_A0A2M8ZCX5 Mesorhizobium-denitrificans_A0A371XEF3Rhizobium-sp-AC4496_A0A1B9S0N9Rhizobium-sp-Root1212_A0A0Q6SR19Mesorhizobium-soli_A0A2P7RVW2Aminobacter-sp-AP02_A0A316GFI2Paenibacillus-sp-FSL-H7-0357_A0A089I4H0Bacillus-sp-Root147_A0A0Q9FTQ7bacterium-BMS3Abin07_A0A2H6FEE0Tolypothrix-sp-NIES-4075_A0A218QSJ0Betaproteobacteria-bacterium_A0A3C1MXQ0Candidatus-Eremiobacter_A0A2W5XBP9 Geminigera-cryophila-Strain-CCMP2564_CAMPEP-0179467070_Geminigera-cryophila-Strain-CCMP2564 bacterium-RmlP001_A0A4Q2RHB6bacterium-RmlP026_A0A4Q2U5B9 Mesorhizobium-sp-WSM1497_A0A1W6XGG8Mesorhizobium-sp-L2C084A000_X6GUL6Mesorhizobium-qingshengii_A0A1G5W090Paenibacillus-sp-FSL-H7-0737_A0A089IPN9Psychrobacillus-sp-PB01_A0A5J6SKL1Fictibacillus-enclensis_A0A0V8JFL0Viridibacillus-arvi_A0A0M0LK08Trichococcus-palustris_A0A143YDI0Bacillus-thuringiensis_A0A4R4BJK3Bacillus-cereus-HuA3-9_R8D2W6Nostoc-cycadae-WK-1_A0A2H6LKQ9Afipia-felis_A0A090MLV7 Rhizobium-sp-BK696_A0A4Q7SCN3Zavarzinia-compransoris_A0A317ECR0Paenibacillus-sp-P22_W8YZT0Lysinibacillus-sp-FJAT-14745_A0A0M0WWS8Paenibacillus-terrae_A0A0D7X316Bacillus-bataviensis-LMG-21833_K6D9L2Bacillus-cereus-HuA2-9_R8D8W4Bacillus-cereus-VDM053_R8P484Bacillus-cereus-HuA2-1_J9C0L1Planktothrix-rubescens_A0A1J1L9G7Afipia-sp-1NLS2_D6V4J1 bacterium_A0A4Q3X4N7 Ignavibacteriae-bacterium-HGW-Ignavibacteriae-4_A0A2N1V389Flavobacteria-bacterium-BAL38_A3J6C1 Mesorhizobium-sp-M7DFCaUS0040311_A0A3S1ZM59Mesorhizobium-sp-LNHC252B00_X6CAQ8bacterium-M00FCaET1560111_A0A4S0ZQT8Mesorhizobium-sp-B2-3-12_A0A503TPE9Rhizobium-sp-GV031_A0A4R2WV57Shinella-sp-WSJ-2_A0A372NF39Thalassospira-mesophila_A0A1Y2KVU8Fictibacillus-sp-S7_A0A4Q2HYY5Paenibacillus-terrae_A0A4U2PSN4Bacillus-sp-AFS017274_A0A2A8TH34Bacillus-sp-ALD_A0A371SP29Bacillus-cereus-BAG6X1-2_J8AQ13Nostoc-linckia-NIES-25_A0A1Z4LGC6Bosea-sp-12-68-7_A0A258A4J2 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Mesorhizobium-sp-M2DFCaET2320111_A0A4R9QH42Mesorhizobium-sp-WSM4308_A0A2A3BME5Mesorhizobium-sp-WSM4315_A0A547L0M2Mesorhizobium-huakuii-7653R_A0A068DCH5Mesorhizobium-sp-Root102_A0A0Q6NKB9Rhizobium-leguminosarum_A0A1B1CIY1Rhizobium-leguminosarum_A0A154I756Bacillus-sp-OV194_A0A1I2D622Bacillus-sp-MYb209_A0A2S8UUW2Bacillus-sp-CDB3_A0A1V9W6W4Bacillus-mycoides_A0A1D3NB57Bacillus-sp-DB-2_A0A366GEL2Bacillus-cereus_A0A2A8TYM9Sulfuriferula-multivorans_A0A401JGG9 Mesorhizobium-sp-M2EFCaET2190111_A0A4R9VTP4Mesorhizobium-sp-M7AFCaUS0010411_A0A435I6P0Mesorhizobium-kowhaii_A0A2W7CXW5Paenibacillus-macquariensis_A0A162M2F6Bacillus-sp-AFS098217_A0A2A7H036Bacillus-sp-OK048_A0A1H0DCS0Bacillus-cereus-HuA4-10_J8DUF8Bacillus-mycoides_C2XVL1Hymenobacter-nivis_A0A2Z3GRR5 Mesorhizobium-sp-M2AFCaET0460321_A0A3Q8Z1Q1Mesorhizobium-sp-M2AFCaET0370111_A0A434ZHT0Mesorhizobium-sp-M2AFCaET0400111_A0A3S1R024Mesorhizobium-sp-M2CTCaTU0020211_A0A3S1NCV3Mesorhizobium-sp-M2EFCaET2090111_A0A4S0JJI1Mesorhizobium-sp-M8AFCaET0570111_A0A3Q9A1B8Mesorhizobium-sp-LSHC414A00_A0A0E2N6F2Mesorhizobium-sp-AP09_A0A395KTS3Mesorhizobium-sp-B2-4-19_A0A503HIG4Rhizobium-etli_A0A327XMW8Delftia-acidovorans_A0A2W5FP64Rhodobacter-sp-SW2_C8S1W9uncultured-bacterium_K2F8Y9Paenibacillus-sp-P46E_A0A1Q5XM05Bacillus-sp-SJS_A0A176J5I6Bacillus-sp-Leaf13_A0A0Q6I6M6Bacillus-cereus_A0A1S9UL31 Mesorhizobium-sp-M2AFCaET0430511_A0A5E8EYY0Mesorhizobium-sp-M2AFCaET0670211_A0A3S1N8Q3Mesorhizobium-sp-M2AFCaET0420111_A0A5E8XLM5Mesorhizobium-sp-CNPSo-3140_A0A330GPE8Mesorhizobium-sp-L2C089B000_V7GYS6Mesorhizobium-sp-B2-3-4_A0A503W7P3Mesorhizobium-sp-B2-6-6_A0A502YQ22Mesorhizobium-sp-Root172_A0A0Q8KDM6Mesorhizobium-sp-B2-1-3A_A0A504BF11Mesorhizobium-erdmanii_A0A4Q1UMJ0Mesorhizobium-intechi_A0A2N7SCG0 Paenibacillus-sp-P3E_A0A1Q5XI61Bacillus-cereus_A0A2B3TX72Bacillus-cereus_A0A2B9PJN4Bacillus-cereus_A0A2C0C750Bacillus-sp-SRB_A0A328LEU6 Mesorhizobium-sp-WSM4313_A0A2A3ALC9Mesorhizobium-sp-WSM3859_A0A2A3DHV8Mesorhizobium-sp-LNJC386A00_X6A3S3Mesorhizobium-sp-L103C119B0_X6K0T9Mesorhizobium-sp-B2-6-5_A0A502XNS0Mesorhizobium-sp-B2-7-3_A0A502WA51Mesorhizobium-sp-B2-5-7_A0A503DZV2Mesorhizobium-sp-LNHC209A00_X6FFX0Mesorhizobium-sp-LNHC220B00_X6EFE6Mesorhizobium-jarvisii_A0A3A5KVP6 Bacillus-loiseleuriae_A0A0K9GY85Bacillus-cereus_A0A2C1ZR82Bacillus-mycoides_C2PX61 Mesorhizobium-sp-B2-6-2_A0A503A9V4Mesorhizobium-sp-B2-8-9_A0A502SFR5Mesorhizobium-sp-ORS-3359_A0A090GNY6Mesorhizobium-sp-LCM-4576_A0A1S1SDY0Mesorhizobium-sp-NFR06_A0A1I5MQX3Mesorhizobium-sp-B4-1-3_A0A502MGG9Mesorhizobium-plurifarium_A0A090EC65Mesorhizobium-plurifarium_A0A090GDE6Mesorhizobium-plurifarium_A0A090F993Mesorhizobium-sp-SARCC-RB16n_A0A5B6TZW6Mesorhizobium-sp-B2-1-8_A0A504A5C3Mesorhizobium-sp-B2-4-17_A0A503K5J8Mesorhizobium-sp-B4-1-4_A0A502MCY2 Mesorhizobium-sp-B1-1-5_A0A504JNT8Mesorhizobium-sp-B2-4-16_A0A503KGI0Mesorhizobium-sp-B3-1-8_A0A502S3T7Mesorhizobium-sp-B2-4-6_A0A503P6B8Mesorhizobium-plurifarium_A0A0K2W7T7Mesorhizobium-sp-SOD10_A0A090F3F8Mesorhizobium-sp-B2-7-1_A0A502ZRD1Mesorhizobium-sp-DCY119_A0A3A3HHB0Mesorhizobium-sp-YR577_A0A1I7CMJ6Mesorhizobium-sp-B2-3-3_A0A504EEG9 Cohnella-abietis_A0A3T1D7M5Bacillus-sp-S3_A0A513RQ35 Gemmatimonadetes-bacterium_A0A2V7RVW1Deltaproteobacteria-bacterium_A0A534XDA9Deltaproteobacteria-bacterium_A0A534RW19 Mesorhizobium-hawassense_A0A330HQ09Rhizobium-loti_A0A1A5IV46Rhizobium-loti_A0A1A5Q6K9Rhizobium-loti_A0A1B4YP50 Sinorhizobium-fredii-USDA-257_I3X435Rhizobium-multihospitium_A0A1C3VWI1Rhizobium-miluonense_A0A1C3U9W7Alphaproteobacteria-bacterium_A0A537NRS9Rhizobium-loti_A0A316CPD4 Rhizobium-hainanense_A0A1C3VHP2Rhizobium-freirei-PRF-81_N6UTE4Rhizobium-sp-BK376_A0A4R3FI03Pseudaminobacter-manganicus_A0A1V8RNH0Rhizobium-sp-P44RR-XXIV_A0A4T3FFB2Mesorhizobium-sp-B1-1-8_A0A504EXH6Rhizobiales-bacterium_A0A3S0EH09 Nocardia-cerradoensis_A0A231GYX8Nocardia-nova_A0A2S6A4A5Nocardia-nova_A0A2S6ASY9Nocardia-sp-852002-20019_A0A1A0J7Z5Nocardia-sp-MDA0666_A0A2T2ZJ80Nocardia-nova_A0A2T2YZ09Mycobacteroides-franklinii_A0A4R8RA01Mycobacteroides-franklinii_A0A1S1LDV9Kroppenstedtia-sanguinis_A0A482TPB4Nocardia-sp-CFHS0054_A0A386Z6R0Mycobacteroides-abscessus-subsp-bolletii_A0A1M9QDN2Mycobacteroides-immunogenum_A0A0N0KNJ3Mycobacteroides-immunogenum_A0A179V8X6Mycobacteroides-sp-H092_A0A0R3EV75Mycobacteroides-immunogenum_A0A0N1LV06Nocardia-sp-YIM-PH-21724_A0A3A4KN84 Rhizobium-sp-BK251_A0A4R1RSH5Neorhizobium-alkalisoli_A0A561R8S8Rhizobiales-bacterium-63-7_A0A1M3AKC0Rhizobium-sp-rho-11_A0A545YY14Mesorhizobium-sp-UASWS1009_A0A1C2DK32Rhizobium-sp-CCGE532_A0A387GYA1Rhizobium-sp-AC2796_A0A1B9RV45Mesorhizobium-sp-65-26_A0A1Q4AG29Mesorhizobium-sp-CU2_A0A504LB69 Rhodococcus-jostii-strain-RHA1_Q0SBZ5Rhodococcus-opacus-strain-B4_C1BCS0Pseudonocardiales-bacterium_A0A2W6E6Z3Pseudonocardiales-bacterium_A0A2W6DHI6Pseudonocardiales-bacterium_A0A2W6DLM0Pseudonocardiales-bacterium_A0A2W6EWD5Nocardia-africana_A0A378WWM0Nocardia-nova-SH22a_W5TFE4Acidimicrobiales-bacterium_A0A2W6BKX5Mycolicibacterium-phlei_A0A448H644Mycobacteroides-salmoniphilum_A0A4R8S3R5Mycobacteroides-abscessus-subsp-abscessus_A0A1M8FX16Mycobacteroides-abscessus-subsp-massiliense_A0A1U4RE86Nocardia-stercoris_A0A3M2L3X4Mycobacterium-stephanolepidis_A0A1Z4EY08 Rhizobium-lusitanum_A0A1C3WE99Rhizobium-sp-60-20_A0A1M3Q560 Rhodococcus-imtechensis-RKJ300-=-JCM-13270_I0WYB9Skermania-sp-ID1734_A0A554V8K5Mycolicibacterium-hodleri_A0A502DM56Mycolicibacterium-cosmeticum_W9BLY3 Phyllobacterium-myrsinacearum_A0A2S9JQ33Phyllobacterium-sp-OV277_A0A1H0UVS2Rhizobium-sp-CF142_J1SHC6Agrobacterium-rhizogenes_A0A546YRH1Rhizobium-sp-BK376_A0A4R3FIA3Pararhizobium-polonicum_A0A1C7P319Rhizobium-loti_A0A117N2F1 Candidatus-Frankia-californiensis_A0A1C3NTN8Pseudonocardiales-bacterium_A0A2W6D079Mycolicibacterium-fortuitum_A0A378V2N6Mycolicibacterium-peregrinum_A0A1A0RFP5Mycolicibacterium-rhodesiae-strain-NBB3_G8RLQ2Rhodococcus-qingshengii_A0A069JEK9Mycolicibacterium-chlorophenolicum_A0A0J6VMN8Mycobacterium-sp-JS623_L0IX34Mycobacterium-sp-WY10_A0A1J0UGC0Mycobacterium-chubuense-strain-NBB4_I4BJJ1Mycolicibacterium-sp-CH28_A0A4Z0N049Mycolicibacterium-aromaticivorans-JS19b1-=-JCM-16368_A0A064CTF4Mycobacterium-sp-852013-50091_A0A1A0X4N7 Rhodobiaceae-bacterium_A0A2Z4UK21Defluviimonas-sp-20V17_A0A059INA3Phyllobacterium-sp-YR620_A0A1H0SPF3Rhizobium-sp-SEMIA4064_A0A2T3GKZ8Rhizobium-radiobacter_A0A4D8A350Rhizobium-tubonense_A0A2W4CR14Inquilinus-limosus_A0A211ZLY5 Streptomyces-sp-NEAU-C40_A0A4U0SRT0Actinokineospora-auranticolor_A0A2S6GDK0Frankia-sp-ACN1ag_A0A0Q1BXV6Frankia-sp-AvVan_A0A4S5CGG1Frankia-alni-strain-ACN14a_Q0RKS8Gandjariella-thermophila_A0A4D4JHS3Kutzneria-buriramensis_A0A3E0HHY7Streptomyces-sp-NEAU-C40_A0A4U0S245Streptomyces-sp-Ag109_A0A1H5HKW9 Ochrobactrum-grignonense_A0A256FRG4Devosia-sp-17-2-E-8_A0A087LU23Rhizobium-sp-BK333_A0A4R6NJE6Rhizobium-jaguaris_A0A387FN58 Streptomyces-scopuliridis-RB72_A0A2T7T8V5Nocardioides-sp-GY-10127_A0A4T0ULF1Streptomyces-sp-WM6378_A0A0M8SPN6Amycolatopsis-acidiphila_A0A558AJC4Streptomyces-sp-MMG1121_A0A0M9ZIA2Streptomyces-sp-MUSC-14_A0A1S2PMA2Streptomyces-hundungensis_A0A387HDI0Streptomyces-mirabilis_A0A1I2WL56Streptomyces-sp-OK885_A0A2N3ZWP4Actinobacteria-bacterium-OK006_A0A0N0MZ45Streptomyces-sp-RLB3-6_A0A515YB40 Devosia-sp-DBB001_A0A024KC21Devosia-sp-SCN-66-27_A0A1E4A926Devosia-riboflavina_A0A087LYS9 Actinoplanes-awajinensis-subsp-mycoplanecinus_A0A101JRN2Actinoplanes-sp-N902-109_R4LDA7Streptomyces-gilvigriseus_A0A1J7C5B7Catenulispora-sp-13_A0A1Q7VQC8Actinomadura-sp-NEAU-Ht49_A0A3M2LGG3 Bradyrhizobiaceae-bacterium-PARB1_A0A257KIV7Tistlia-consotensis-USBA-355_A0A1Y6CTX4Bradyrhizobium-sp-Leaf396_A0A0Q5ZTA5Enhydrobacter-aerosaccus_A0A1T4SCJ8Devosia-psychrophila_A0A0F5PZ49 Streptomyces-sp-NEAU-D10_A0A371QB15Streptomyces-sp-23231_A0A286I7P0Streptomyces-gilvosporeus_A0A1V0TUL5Streptomyces-sioyaensis_A0A4Q1RC36Streptomyces-auratus-AGR0001_J2JU33Streptomyces-sp-ISID311_A0A5C6WJC8Streptomyces-chattanoogensis_A0A0N0XWN4Streptomyces-natalensis-ATCC-27448_A0A0D7CT57Streptomyces-sp-23144_A0A1H4L0N4Streptomyces-lydicus_A0A1D7VKD3Streptomyces-angustmyceticus_A0A5J4LE23Streptomyces-sp-76_A0A2G6WR66Streptomyces-sp-MOE7_A0A1W5XJA4Streptomyces-sp-22335_A0A2G6Z0R4 Streptomyces-sp-Alain-F2R5_A0A270QKE6Zhengella-mangrovi_A0A2G1QIB7 Actinomadura-darangshiensis_A0A4R5BA05Streptomyces-sp-93_A0A2G7C5K9Streptomyces-sp-94_A0A2G7AF79Actinobacteria-bacterium-OK006_A0A0N1GLS5Streptomyces-olivochromogenes_A0A250V306Streptomyces-mirabilis_A0A1I2KE78Streptomyces-sp-RLB3-6_A0A515YRG0Streptomyces-sp-42_A0A495CLH0Streptomyces-sp-OK228_A0A2C8XHC4Streptomyces-sp-CB02959_A0A2M9LZU5Streptomyces-sp-74_A0A497W1N7Streptomyces-sp-OK885_A0A2N4A0Q8Streptomyces-sp-70_A0A2G7FAE4Streptomyces-avermitilis-strain-ATCC-31267--DSM-46492--JCM-5070--NBRC-14893--NCIMB-12804--NRRL-8165--MA-4680_Q82RL3Streptomyces-sp-yr375_A0A1H9SS34Streptomyces-sp-MZ04_A0A4R9EU01Streptomyces-sp-MZ03-48_A0A553Z6B3 Amycolatopsis-saalfeldensis_A0A1H8YPH6Streptomyces-sp-BK329_A0A4R3BTU6Streptomyces-sp-Ag109_A0A1H5HPV1Streptomyces-sp-Ncost-T10-10d_A0A1C5BR59Streptomyces-sp-BK308_A0A4R3CIB5Saccharothrix-sp-ST-888_A0A0F0HHV4Streptomyces-bungoensis_A0A101T0M5Streptomyces-atratus_A0A2Z5JTZ1 Cyanobacteria-bacterium-UBA11371_A0A351KYP1Oscillatoria-nigro-viridis-PCC-7112_K9VJN5Nostoc-sp-Peltigera-membranacea-cyanobiont-210A_A0A235IJX5Cyanobacteria-bacterium-J055_A0A3M1THZ6Amycolatopsis-niigatensis_A0A2N3WL40Amycolatopsis-vastitatis_A0A229SLG4Streptomyces-sp-PRh5_A0A014LPS3Streptomyces-sp-WAC05858_A0A429QFH0Streptomyces-sp-NBS-1410_A0A229HD36Streptomyces-bingchenggensis-strain-BCW-1_D7C9I6Streptomyces-violaceusniger_A0A4D4KSP3Streptomyces-violaceusniger_A0A0X3VRG8Streptomyces-sp-22311_A0A1H5HX03Streptomyces-sparsogenes-DSM-40356_A0A1R1SBI5Streptomyces-sp-BK340_A0A559TWR4Streptomyces-sp-M56_A0A2K8REJ9Streptomyces-mangrovisoli_A0A1J4NT02Streptomyces-sp-Ag109_A0A3N4SGM0Streptomyces-sp-San01_A0A3S2W6A7Streptomyces-sp-NRRL-B-3648_A0A0M8WVT4Streptomyces-sp-PanSC9_A0A3N1HZ00Streptomyces-sp-CB01883_A0A1Q5KBP1Streptomyces-sp-BK674_A0A4R3DYH7Streptomyces-noursei-ATCC-11455_A0A1B2H393Streptomyces-albulus_A0A401QSU8Streptomyces-sp-MJM1172_A0A1Q5AUB4Actinobacteria-bacterium-OK074_A0A0N1NI94Streptomyces-roseus_A0A0J6XFA5 Paenibacillus-terrae_A0A4U2PVY9Prokaryotes-Bacteria-Chloroflexi_Dictyobacter-alpinus_A0A402BCE9Nostoc-commune-NIES-4072_A0A2R5FFE3Prokaryotes-Bacteria-Chloroflexi_Ktedonobacter-racemifer-DSM-44963_D6TVZ0filamentous-cyanobacterium-Phorm-46_A0A2T1EB85Chroogloeocystis-siderophila-52-sc1_A0A1U7HUB4Prokaryotes-Bacteria-Chloroflexi_Dictyobacter-sp-W12_A0A5J4KXQ2Planktothrix-sp-PCC-11201_A0A1T4ZFW8Nostoc-calcicola-FACHB-389_A0A1U7I0T7filamentous-cyanobacterium-Phorm-6_A0A2T1G5L1Nostocales-cyanobacterium-HT-58-2_A0A1Y0RF57Hydrococcus-rivularis-NIES-593_A0A1U7HCN6Planktothrix-tepida-PCC-9214_A0A1J1LP86Streptomyces-sp-69_A0A2N0IWS8Streptomyces-sp-Z022_A0A3G2JJS3Streptomyces-sp-NRRL-B-3648_A0A0M8X5R1Streptomyces-sp-K1PN6_A0A5N8WVM0Streptomyces-sp-BK447_A0A4R7I6D6Streptomyces-violaceusniger-strain-Tu-4113_G2PE95Streptomyces-sp-11-1-2_A0A222T965Streptomyces-hygroscopicus_A0A1S6RXP3Streptomyces-rapamycinicus-strain-ATCC-29253--DSM-41530--NRRL-5491--AYB-994_A0A3L8R9K6Streptomyces-sp-Ru73_A0A2S4Y0Q7Streptomyces-nodosus_A0A0B5DDM1Streptomyces-seoulensis_A0A4P6TR97 Brevibacillus-choshinensis_A0A0Q3WPW8Paenibacillus-kribbensis_A0A222WNP3Paenibacillus-polymyxa-strain-E681_E0RKH3Paenibacillus-sp-MS2379_A0A544WTC0Paenibacillus-polymyxa_A0A5B8IVA7Desulfosporosinus-sp-OT_G2FL47Pleurocapsa-sp-PCC-7327_K9T7J2Synechococcus-sp-strain-ATCC-27167_K9RWT5Streptomyces-sp-6-11-2_A0A4Y4KMK4Streptomyces-sp-1-11_A0A510T8E1Streptomyces-sp-32124_A0A495HCA7Streptomyces-sp-75_A0A3D9NYU8Streptomyces-sp-FXJ1172_A0A176L0F9Streptomyces-puniciscabiei_A0A542UDF5Streptomyces-puniciscabiei_A0A1D7YAS5Streptomyces-incarnatus_A0A0G3ABV0Streptomyces-sp-IMTB-2501_A0A1R0LZW3Streptomyces-cellostaticus_A0A117PX64Streptomyces-griseochromogenes_A0A1B1BC12Streptomyces-roseochromogenus-subsp-oscitans-DS-12976_V6KGN8Streptomyces-sp-BK340_A0A559V276Streptomyces-sp-BK141_A0A4V3EH70 Cryobacterium-psychrophilum_A0A4Y8KL59 Bacillus-sp-ALD_A0A371TMZ9 Streptomyces-sp-BK161_A0A4R7HTI9Streptomyces-sp-Root369_A0A0Q6X492Microbispora-sp-KK1-11_A0A544ZGQ0Frankia-sp-BMG530_A0A1V2IV72Frankia-symbiont-subsp-Datisca-glomerata_F8B3T5Streptomyces-sp-yr375_A0A1H9A2B3Streptomyces-sp-32133_A0A1H5M201Streptomyces-sp-MUSC-93_A0A1S2PLI3Streptomyces-griseoruber_A0A101SM78Streptomyces-sp-DSM-15324_A0A124IBZ9Streptomyces-sp-DSM-15324_A0A101UBN4Streptomyces-sp-NRRL-WC-3618_A0A0M8WE09Streptomyces-sp-CB01635_A0A2M9JRG1Streptomyces-sp-JV178_A0A2G9DZL3Streptomyces-sp-CdTB01_A0A0U3PSN4Streptomyces-canus_A0A101RLN3Streptomyces-sp-BK335_A0A4R3IGX6Streptomyces-sp-Ag82_A0A3D9WDY4Streptomyces-diastatochromogenes_A0A233ST94Streptomyces-sp-MUSC-1_A0A1S2QGV4Streptomyces-sp-MUSC-14_A0A1S2QBI5Streptomyces-yokosukanensis_A0A101PBY2Streptomyces-collinus-strain-DSM-40733--Tu-365_S5VTJ2Streptomyces-sp-F-1_A0A1K2FTB5 Cryobacterium-sp-MDT1-3_A0A4R8WJ42Sanguibacter-gelidistatuariae_A0A1G6MPJ7 Bacillus-sp-Soil531_A0A0Q9UXS3Bacillus-aryabhattai_A0A2C5HT72Bacillus-megaterium_A0A2A8VQ12 Nonomuraea-sp-KC712_A0A4R4WPT0Streptomyces-sp-VMFN-G11Ma_A0A2T5B0D0Streptomyces-sp-NRRL-F-5122_A0A0X3RS25Streptomyces-sp-32123_A0A3D9QRS0Streptomyces-acidiscabies_A0A117E6K6Streptomyces-malaysiense_A0A1J4Q1D7 Cryobacterium-sp-TMT1-66-1_A0A5R1NT79Cryobacterium-sp-TMS1-13-1_A0A4R8Z8F0Cryobacterium-sp-HLT2-23_A0A4R8V1S6Cryobacterium-sp-TMT1-1_A0A4R8ZCY6Cryobacterium-sp-RHLS22-1_A0A4R8W5C7 Paenibacillus-selenitireducens_A0A1T2X1B7Frankia-sp-EUN1f_D3CY57Frankia-canadensis_A0A2I2KPB5Frankia-asymbiotica_A0A1V2I059 Cryobacterium-roopkundense_A0A099J3I2Cryobacterium-sp-TmT2-59_A0A4R8Y8P5Cryobacterium-sp-MLB-32_A0A086E0A0Cryobacterium-sp-Sr54_A0A4R9BN00Cryobacterium-sp-Hz16_A0A4R9AZ90Cryobacterium-sp-Hz9_A0A4R8UVN0Cryobacterium-sp-Sr36_A0A4R9ATY6Cryobacterium-arcticum_A0A1B1BQC6 Dehalobacter-sp-TeCB1_A0A1C2XQM1Frankia-sp-EUN1h_A0A1S1QKW3Frankia-asymbiotica_A0A1V2HZ94Frankia-canadensis_A0A2I2KWT3Frankia-inefficax-strain-DSM-45817_E3J7X6 Microbacteriaceae-bacterium_A0A3C1DY68Cryobacterium-sp-Hh11_A0A4R9A691Frondihabitans-sp-PhB153_A0A3N4V8P0Cryobacterium-flavum_A0A4R8UV79 Frondihabitans-sp-762G35_A0A2R2WDJ5Cryobacterium-sp-Sr59_A0A4R9BI67 Bacillus-koreensis_A0A0M0L915 Bacillus-sp-AFS017336_A0A2H3N1F1Bacillus-sp-AFS002410_A0A2A7WYP1Bacillus-sp-AFS088145_A0A2A9RIX1Bacillus-sp-AFS053548_A0A2B9AKA3Bacillus-sp-FJAT-25509_A0A0Q3WC49 Bacillus-sp-WN066_A0A4R5VHZ5Bacillus-sp-AFS096315_A0A2A7IAI4Bacillus-luciferensis_A0A1E2W6G8Bacillus-sp-FJAT-27238_A0A0K9MFD6Paenibacillus-cellulosilyticus_A0A2V2YT40Brevibacillus-fluminis_A0A3M8DNS7 Thiothrix-lacustris_A0A1Y1QK76 hydrothermal-vent-metagenome_A0A1W1CX51Vampirococcus-sp-LiM_A0A410P382Thalassolituus-oleivorans-MIL-1_M5DP29 Curtobacterium-sp-MCBA15_A0A1S2HKJ0 Bacteroidetes-bacterium-46-16_A0A1Q3X2K5Methylophaga-sulfidovorans_A0A1I3U259 Micrococcales-bacterium-70-64_A0A1Q4AQ51marine-actinobacterium-PHSC20C1_A4AIE0Curtobacterium-sp-Ferrero_A0A2A5NWX5Curtobacterium-sp-MCLR17_A0A2W1U5M4Curtobacterium-sp-KBS0715_A0A554N3F6Curtobacterium-sp-PhB137_A0A3N4W7I7Curtobacterium-sp-PhB78_A0A3N2HDQ5 Microbacterium-trichothecenolyticum_A0A0M2HHK4Salinibacterium-xinjiangense_A0A2C8ZGM8Curtobacterium-sp-MMLR14_A0A1S2JJ14Luteimicrobium-subarcticum_A0A2M8WUT9Curtobacterium-sp-UNCCL20_A0A1H1FR79Curtobacterium-sp-JUb34_A0A3N1XUM1 candidate-division-BRC1-bacterium-HGW-BRC1-1_A0A2N2PHY6Sulfurovum-sp-39-42-12_A0A259HBG9 Microbacterium-sp-CH12i_A0A062VKX9Microbacterium-oxydans_A0A0F0KBU2Microbacterium-sp-MYb72_A0A2S9AB41Microbacterium-sp-BK664_A0A4Q7RMJ3Frigoribacterium-sp-Leaf172_A0A0Q5MTX4 Microbacterium-mangrovi_A0A0B2A2P4Frigoribacterium-sp-Leaf164_A0A0Q5L6F0Frigoribacterium-sp-PhB107_A0A3N1KKZ6Kineococcus-rhizosphaerae_A0A2T0QXI4Frigoribacterium-sp-PhB24_A0A3N2I974Frigoribacterium-sp-PhB160_A0A3N2IJ14Cellulomonas-sp-PhB150_A0A3N2G2N4Leifsonia-sp-Leaf336_A0A0Q5LZW8Cellulomonas-soli_A0A512PHE7 Microterricola-sp-OV434_A0A420BMH3Naasia-lichenicola_A0A4S4FUA4Microterricola-viridarii_A0A0Y0PGC2Agromyces-sp-CF514_A0A1I6J6P0Frigoribacterium-faeni_A0A511A779Oryzihumus-leptocrescens_A0A542ZNS4 Aliiglaciecola-lipolytica-E3_K6X8D5 Naasia-lichenicola_A0A4S4FQG8Plantibacter-sp-Leaf314_A0A0Q5E1A5Microterricola-gilva_A0A4Q8APX5Plantibacter-sp-YR521_A0A495AVB7Leifsonia-sp-Root60_A0A0Q8CRD9 Quadrisphaera-granulorum_A0A316A4P5Modestobacter-sp-DSM-44400_A0A1H3D1F6Blastococcus-sp-CT_GayMR16_A0A4Y9QJI3Modestobacter-multiseptatus_A0A543C5I4Blastococcus-aggregatus_A0A285V7I0Klenkia-brasiliensis_A0A1G7USG4Leifsonia-sp-OV430_A0A420X5R4Plantibacter-flavus_A0A4U3FS44 Flavisolibacter-ginsenosidimutans_A0A5B8UKE7 Clostridium-sp-Maddingley-MBC34-26_K6T8H1Mycolicibacterium-chlorophenolicum_A0A0J6W984 Klenkia-soli_A0A1H0GNG6Klenkia-soli_A0A1H0IRK4 Frondihabitans-australicus_A0A495IBS6Streptomyces-sp-8465_A0A4R7MI42Actinobacteria-bacterium-OK074_A0A0N1NP19 Mycolicibacterium-cosmeticum_W9AVI0 Gammaproteobacteria-bacterium_A0A2E6M223Fulvimarina-manganoxydans_A0A1W2C3H7 Ethanoligenens-harbinense-strain-DSM-18485_E6U4P5Microbacteriaceae-bacterium_A0A522P1K5Cnuibacter-physcomitrellae_A0A1X9LQX3Cnuibacter-physcomitrellae_A0A1X9LUL5Humibacter-sp-BT305_A0A345K3X1Humibacter-sp-BT305_A0A345JXA6 Flavobacterium-degerlachei_A0A1H3GGE3Chitinophaga-ginsengisoli_A0A2P8FUD1 Paenibacillus-sp-BK033_A0A4R1ZWF4Paenibacillus-sp-strain-JDR-2_C6D8G6Lucifera-butyrica_A0A498RDG8Ethanoligenens-harbinense_A0A386XPH4Microbacterium-lemovicicum_A0A3Q9IW76Subtercola-sp-Z020_A0A2S5W845Mycobacterium-sp-JS623_L0ITL4 Rhodobiaceae-bacterium_A0A2Z4UJT2Hyphomicrobium-sp-strain-MC1_F8JCN5Alphaproteobacteria-bacterium_A0A4Q3YY57Anabaena-cylindrica-strain-ATCC-27899--PCC-7122_K9ZRX4 Paenibacillus-sp-18JY67-1_A0A3Q8X7H7Paenibacillus-sp-BK736_A0A4R3D1I8Paenibacillus-sp-OV219_A0A1H7Z539Sporolactobacillus-laevolacticus-DSM-442_V6IVJ6Sporolactobacillus-shoreae_A0A4Z0GR68Desulfosporosinus-acididurans_A0A0J1FSA4Herbiconiux-ginsengi_A0A1H3SPX1 Olleya-sp-Bg11-27_A0A2K8X2Y7Bizionia-algoritergicola_A0A5D0QS82Kriegella-aquimaris_A0A1G9SLH7Flavobacterium-frigoris-strain-PS1_H7FLI7Other_MATOU-v2_682867051Hyphomicrobium-facile_A0A1I7MUG4Rhizobium-sp-PP-WC-1G-195_A0A2V4UBT1Rhizobium-sp-PP-CC-2G-626_A0A4R2SGU3Hwanghaeicola-aestuarii_A0A2W7MYU3Fischerella-thermalis-CCMEE-5330_A0A2N6M938Hydrococcus-rivularis-NIES-593_A0A1U7HSK2Fischerella-sp-NIES-3754_A0A0S3TH80Hapalosiphonaceae-cyanobacterium-JJU2_A0A328IBF7 Paenibacillus-sp-UNC496MF_A0A1I3QMP6Paenibacillus-baekrokdamisoli_A0A3G9J094Paenibacillus-sp-BK736_A0A4R3CMQ9Paenibacillus-taihuensis_A0A3D9SPK5Pelosinus-sp-UFO1_A0A075K7T9 Leeuwenhoekiella-nanhaiensis_A0A2G1VLN3Ulvibacter-antarcticus_A0A3L9YG13Mariniflexile-fucanivorans_A0A4R1RJ67Rhizobium-sp-rho-11_A0A545YY39marine-sediment-metagenome_A0A0F9U5D3Rhodobacteraceae-bacterium_A0A2D8L628Rhizobium-phaseoli_A0A2U3CLI4Fremyella-diplosiphon-NIES-3275_A0A1Z4MNV2Fischerella-muscicola-CCMEE-5323_A0A2N6K4P0Fischerella-major-NIES-592_A0A1U7H306Nostoc-cycadae-WK-1_A0A2H6LKR4Fischerella-thermalis-CCMEE-5205_A0A2N6LV91Trichormus-variabilis-NIES-23_A0A1Z4KW45Nostoc-sp-strain-PCC-7120--SAG-2582--UTEX-2576_Q8ZS86Tolypothrix-sp-NIES-4075_A0A218QUC1Nostoc-sp-Peltigera-membranacea-cyanobiont-N6_A0A2L2NFJ6Nostoc-sp-Peltigera-membranacea-cyanobiont-213_A0A235IDK2 Paenibacillus-sp-JC52_A0A559K4K9Cohnella-sp-OV330_A0A1I0YMT0Paenibacillus-pectinilyticus_A0A1C0ZW17 Aequorivita-sublithincola-strain-DSM-14238_I3YVH1Aequorivita-antarctica_A0A5C6Z3D7Gramella-fulva_A0A2R3Z960Chryseobacterium-frigidisoli_A0A1I3DB66Maribacter-sp-T28_A0A1B7Z4I1Flavobacterium-sp-ALD4_A0A2N1G975Zhengella-mangrovi_A0A2G1QIE9Hyphomicrobium-sp-GJ21_A0A218PME3Nostoc-punctiforme-strain-ATCC-29133--PCC-73102_B2JBG6Nostoc-sp-Peltigera-membranacea-cyanobiont-232_A0A235J8Z6Nostoc-punctiforme-NIES-2108_A0A367R2Y9Calothrix-brevissima-NIES-22_A0A1Z4K3N5Tolypothrix-tenuis-PCC-7101_A0A1Z4NBN2Nostoc-sp-RF31YmG_A0A252DIY0Nostoc-linckia-NIES-25_A0A1Z4LGD3Nostoc-sp-HK-01_A0A2Z6CZE8Chroococcidiopsis-thermalis-strain-PCC-7203_K9U9M2 Bacillus-sp-MUM-13_A0A1S2QXB1Bacillus-sp-MUM-116_A0A1S2R489Bacillus-cucumis_A0A2N5HFI3Bacillus-sp-WN066_A0A4R5VIV3Bacillus-sp-OK838_A0A239NJT3Bacillus-sp-AFS018417_A0A2A8S6D8Aneurinibacillus-soli_A0A0U5B202Bacillus-sp-LF1_A0A0U1P4I2 Aequorivita-soesokkakensis_A0A1A9LAV3Flavobacteriaceae-bacterium-JJC_A0A246AJ01Maribacter-arcticus_A0A1T5AI59Muricauda-sp-72_A0A3A1NK40Muricauda-sp-NH166_A0A418NCH2Maribacter-orientalis_A0A1H7LTW5Salinisphaera-hydrothermalis-strain-C41B8_A0A084IGN1filamentous-cyanobacterium-CCP5_A0A2P8WE55Nostoc-punctiforme-strain-ATCC-29133--PCC-73102_B2IW25Chroococcidiopsis-sp-CCALA-051_A0A2P8QVT0Tolypothrix-sp-NIES-4075_A0A218QSU6 Bacillus-sp-AFS002410_A0A2A7WXU5Bacillus-sp-FJAT-25509_A0A0Q3W4F4Bacillus-sp-AFS001701_A0A2A8MN79Bacillus-sp-AFS053548_A0A2B9B0P4Bacillus-sp-AFS077874_A0A2B1GXC5Bacillus-sp-AFS088145_A0A2A9RRD7Bacillus-sp-NFR08_A0A368WB22 Aequorivita-sp-CIP111184_A0A330MJ59Flavobacterium-glycines_A0A1B9DKQ1Chryseobacterium-antarcticum_A0A448NP80Sphingobacteriales-bacterium-44-61_A0A1Q3TCP7Maribacter-spongiicola_A0A4R7K6R4marine-sediment-metagenome_A0A0F9WDW7Salinisphaera-sp-LB1_A0A2Z3J865Rhizobium-sp-BK376_A0A4R3FGD2 Bacillus-sp-AFS055030_A0A2B8U251Bacillus-sp-BK245_A0A4R1Y435Bacillus-luciferensis_A0A1E2VWF1 Gillisia-sp-Hel1_A0A1H1UV58Algoriphagus-aquimarinus_A0A1I1BRJ9Marinifilaceae-bacterium-T3-2-S1-C_A0A434AY56Chryseobacterium-sp-SNU-WT5_A0A516P5Z5Chryseobacterium-daecheongense_A0A3N0W753Hyphomicrobium-denitrificans-strain-ATCC-51888_D8JRE2Hyphomicrobium-denitrificans-1NES1_N0B2F8 Clostridium-acidisoli-DSM-12555_A0A1W1X8C1 Algoriphagus-ratkowskyi_A0A2W7R9M4Chryseobacterium-sp-YR221_A0A1W1YI96Chryseobacterium-koreense-CCUG-49689_A0A0J7J253Flavobacteria-bacterium-BAL38_A3J6C2Ignavibacteriae-bacterium-HGW-Ignavibacteriae-4_A0A2N1V3D4Rhodobacteraceae-bacterium_A0A2E2KYY0Hyphomicrobium-sp-GJ21_A0A218PLB4 Prokaryotes-Bacteria-Chloroflexi_Ktedonobacter-racemifer-DSM-44963_D6TG10Prokaryotes-Bacteria-Chloroflexi_Chloroflexi-bacterium_A0A317GUI3Clostridium-pasteurianum-BC1_R4K4B2Clostridium-sp-BL-8_A0A1S8TBU5 Algoriphagus-aquimarinus_A0A5C7AF85Chitinophagaceae-bacterium_A0A4V2AN11Flavobacterium-faecale_A0A2S1LIJ8Flavobacterium-microcysteis_A0A501Q085Cellulophaga-algicola-strain-DSM-14237_E6XDF9marine-sediment-metagenome_A0A0F9QL26Sinorhizobium-fredii-USDA-257_I3X3X5Thauera-terpenica-58Eu_T0ASW5 Prokaryotes-Bacteria-Chloroflexi_Ktedonosporobacter-rubrisoli_A0A4P6K2V3Prokaryotes-Bacteria-Chloroflexi_Chloroflexi-bacterium_A0A522NBJ7Prokaryotes-Bacteria-Chloroflexi_Chloroflexi-bacterium_A0A2W6AQP5Prokaryotes-Bacteria-Chloroflexi_Chloroflexi-bacterium_A0A535T7D8Prokaryotes-Bacteria-Chloroflexi_Chloroflexi-bacterium_A0A535FNL8 Chryseobacterium-sp-ERMR1_A0A0N0LJ68Chryseobacterium-sp-JM1_A0A086B0B4Chryseobacterium-contaminans_A0A1M7CLK3Chryseobacterium-sp-StRB126_A0A077KQ76Chryseobacterium-sp-CH25_A0A4Q1FNU3Chryseobacterium-oncorhynchi_A0A316X1I5Chryseobacterium-carnis_A0A3G8XFN7Acinetobacter-brisouii-CIP-110357_V2UCD9Algibacter-lectus_A0A090WAL7Algibacter-wandonensis_A0A4V3HGD3Algibacter-sp-RHA_A0A2N0JFH5Thermosynechococcus-sp-NK55a_V5V3V1 Salinisphaera-hydrothermalis-strain-C41B8_A0A084IPU3Prokaryotes-Bacteria-Chloroflexi_Chloroflexi-bacterium_A0A535UZX7Thermogemmatispora-tikiterensis_A0A328VID5Thermogemmatispora-argillosa_A0A455T653Thermogemmatispora-aurantia_A0A5J4KCI5 Meridianimaribacter-sp-CL38_A0A4Q9RVK4Flavobacteriaceae-bacterium_A0A2D4YDT4Chryseobacterium-sp-52_A0A2G6UCQ9Chryseobacterium-sp-T16E-39_A0A220SH21Chryseobacterium-sp-G0162_A0A3G6S742Chryseobacterium-jejuense_A0A2X2VNC2Chryseobacterium-joostei_A0A1N7HXW6Chryseobacterium-nakagawai_A0A3S5EPY1Chryseobacterium-sp-1_F178_A0A3D9C2U7Chryseobacterium-sediminis_A0A5B2UA11Chryseobacterium-rhizoplanae_A0A521BI58Chryseobacterium-sp-ISE14_A0A316XFS2Chryseobacterium-sp-NBC122_A0A4V1ALB7Sphingobacterium-sp-ML3W_A0A088F277Sphingobacterium-detergens_A0A420BH22Chitinophaga-caeni_A0A291QVR1Cellulophaga-sp-RHA_A0A559N9A1Gramella-forsetii-strain-KT0803_A0M0Q1 Desulfosporosinus-acidiphilus-strain-DSM-22704_I4DB64Desulfosporosinus-acidiphilus-strain-DSM-22704_I4D7L7Salinisphaera-sp-LB1_A0A2Z3J4R1Alicyclobacillus-ferrooxydans_A0A0P9CZ70Desulfosporosinus-acididurans_A0A0J1FSA9 Other_MATOU-v2_292431033Aequorivita-sp-H23M31_A0A410G0T1Chitinophagaceae-bacterium_A0A4V2A9T4Bacteroidales-bacterium_A0A3D0HUY8Chryseobacterium-nakagawai_A0A448LJ68Chryseobacterium-nakagawai_A0A3N2EYR7Chryseobacterium-culicis_A0A2S9CXY0Chryseobacterium-sp-HMWF028_A0A2R7P2B4Chryseobacterium-sp-Gsoil-183_A0A5D8ZZA9Rhizobium-sp-Root1212_A0A0Q6SVU4 Sulfobacillus-thermotolerans_A0A3S6Z5E9Alicyclobacillus-acidoterrestris-strain-ATCC-49025_T0DNA3Sulfobacillus-sp-hq2_A0A2S3QKK6Acidibacillus-ferrooxidans_A0A101XRG5Acidibacillus-ferrooxidans_A0A162SKU6Acidibacillus-ferrooxidans_A0A101XSW9Alicyclobacillus-ferrooxydans_A0A0P9EYG7Acidibacillus-ferrooxidans_A0A1V4EVQ2Acidibacillus-ferrooxidans_A0A162S9P3Firmicutes-bacterium-I2511_A0A418MDF9 Flavobacterium-sp-TAB-87_A0A105TR41Bacteroidetes-bacterium-HGW-Bacteroidetes-22_A0A2N2Y3W3Chryseobacterium-piperi_A0A086AE35Chryseobacterium-artocarpi_A0A1B8ZKX3Chryseobacterium-ureilyticum_A0A1N7LEV5Chryseobacterium-sp-CH21_A0A4V1MGD3Chryseobacterium-sp-7_A0A497US23Chryseobacterium-gleum_A0A3S4QUE8Chryseobacterium-aquifrigidense_A0A543EJ35Chryseobacterium-sp-AG363_A0A420CSR6Chryseobacterium-sp-KBW03_A0A3N7AIT6Chryseobacterium-indologenes_A0A5R9PU80Chryseobacterium-arthrosphaerae_A0A1B8ZQP6Chryseobacterium-indologenes_A0A4V6IAQ8 Alicyclobacillus-acidocaldarius-strain-Tc-4-1_F8IKT5Alicyclobacillus-acidocaldarius-LAA1_B7DRT5Alicyclobacillus-vulcanalis_A0A1N7JJ70Alicyclobacillus-hesperidum-URH17-3-68_J9HTU7Alicyclobacillus-tengchongensis_A0A0V0PN97Alicyclobacillus-hesperidum_A0A1H2VP54Peptococcaceae-bacterium-CEB3_A0A0J1FJ82Alicyclobacillus-sacchari_A0A4R8LLB3Acidibacillus-sulfuroxidans_A0A2U3DBL1 Fabibacter-pacificus_A0A1I0Q193Chryseobacterium-shigense_A0A1N7IG14Chryseobacterium-viscerum_A0A316WE06Chryseobacterium-sp-MYb7_A0A2S8ZLW9Chryseobacterium-sp-G0240_A0A3N0WLN0 Alicyclobacillus-acidocaldarius-subsp-acidocaldarius-strain-ATCC-27009_C8WTR7Alicyclobacillus-montanus_A0A1M6LWE3 Chryseobacterium-oranimense_A0A1M5R7E2 Acidithiobacillus-caldus-strain-ATCC-51756_A0A059ZV38Acidithiobacillus-caldus-strain-SM-1_F9ZP59Acidihalobacter-prosperus_A0A1D8IPM6Acidithiobacillus-ferrooxidans_A0A2W1K0E2Acidithiobacillus-thiooxidans_A0A1C2JLK4Acidithiobacillus-ferrooxidans_A0A365YFI2Acidithiobacillus-thiooxidans_A0A1C2I9J2Acidithiobacillus-ferrooxidans_A0A179BI35Acidithiobacillus-ferrivorans_A0A257SJE2Acidithiobacillus-sp-GGI-221_F8XP04 Chitinophagaceae-bacterium_A0A4Q5UUV8 Acidithiobacillus-sp-AMD-consortium_A0A5J6VPA5Thermodesulfobium-narugense-DSM-14796_M1E581Acidithiobacillus-thiooxidans_A0A1C2I1R3Acidithiobacillus-ferrivorans_A0A060UU60Acidithiobacillus-ferrivorans_A0A060URG9Acidithiobacillus-ferrivorans_A0A1B9BVY5Acidithiobacillus-ferrivorans-SS3_G0JNZ2Acidiphilium-sp-20-67-58_A0A257R7A4Acidiphilium-sp-JA12-A1_A0A066PSK7mine-drainage-metagenome_E6PRU8Thiomonas-sp-X19_A0A238DS22 Sphingobacteriales-bacterium_A0A4Q3D8U8 Acidiphilium-multivorum-strain-DSM-11245_F0J5M1Acidiphilium-sp-21-60-14_A0A257S6N1Thiomonas-arsenitoxydans-strain-DSM-22701_D6CS35Acidimicrobiales-bacterium_A0A2W6CCV4 Burkholderia-dabaoshanensis_A0A2N7VR81 Acidocella-aminolytica-101-=-DSM-11237_A0A0D6PBL3Prokaryotes-Bacteria-Chloroflexi_Chloroflexi-bacterium_A0A535E977Prokaryotes-Bacteria-Chloroflexi_Chloroflexi-bacterium_A0A3B9M7P6Prokaryotes-Bacteria-Chloroflexi_Tengunoibacter-tsumagoiensis_A0A402A6S8Prokaryotes-Bacteria-Chloroflexi_Dictyobacter-alpinus_A0A402B7G4Prokaryotes-Bacteria-Chloroflexi_Dictyobacter-sp-W12_A0A5J4L368Prokaryotes-Bacteria-Chloroflexi_Dictyobacter-sp-Uno17_A0A5A5T775Prokaryotes-Bacteria-Chloroflexi_Dictyobacter-kobayashii_A0A402AVD4Leptolyngbya-frigida-ULC18_A0A2T1E125Oscillatoria-nigro-viridis-PCC-7112_K9VCD3 Desulfurella-amilsii_A0A1X4XZJ7Desulfurella-multipotens_A0A1G6JPC5 Prokaryotes-Bacteria-Chloroflexi_Ktedonobacter-racemifer-DSM-44963_D6TVN9Prokaryotes-Bacteria-Chloroflexi_Dictyobacter-aurantiacus_A0A401ZGQ9Actinobacteria-bacterium_A0A3D3YUW4 Proteobacteria-bacterium_A0A4Q6DF16Oxalobacteraceae-bacterium_A0A4Q3L891 Rhizobium-sp-BK376_A0A4R3FGH6Streptacidiphilus-jiangxiensis_A0A1H7HWC1Defluviimonas-sp-20V17_A0A059IPE3Kutzneria-buriramensis_A0A3E0HIR6Rhizobium-sp-rho-11_A0A545YY36Oryzihumus-leptocrescens_A0A542ZF85Microbacteriaceae-bacterium_A0A3C1DZU5Streptacidiphilus-pinicola_A0A2X0ICH1Arthrobacter-sp-ERGS1_A0A0M3T3E8Bacillus-sp-SRB_A0A328LG51 Sphingomonas-sp-JUb134_A0A4V2THR4 Glaciihabitans-sp-CHu50b-6-2_A0A5C8UW07Cellulomonas-sp-PhB150_A0A3N2G1X1Rhodococcus-sp-C1-24_A0A5A7S7S3Arthrobacter-livingstonensis_A0A2V5LPD4Arthrobacter-alpinus_A0A0M4QT96Arthrobacter-sp-Hiyo1_A0A0S7CSN0Terrabacter-aerolatus_A0A512CZG5 Solirubrobacterales-bacterium-70-9_A0A1M3B7F0Arthrobacter-sp-SRS-W-1-2016_A0A1S9MDK5Arthrobacter-sp-ok909_A0A1H0VVI0Cryobacterium-sp-MDB2-B_A0A4R8VKB4Arthrobacter-sp-ok909_A0A1H0VUS7Cryobacterium-sp-MDB2-33-2_A0A5F0DL03Arthrobacter-oryzae_A0A495EAT4Streptomyces-gilvigriseus_A0A1J7C9H7Pseudonocardia-sp-73-21_A0A1Q4D7K1Pseudonocardia-sp-N23_A0A292YLW7Pseudonocardia-sp-73-21_A0A1Q4E4U6 Pseudonocardia-dioxanivorans-strain-ATCC-55486_F4CJT9Actinoplanes-sp-strain-ATCC-31044_G8SJE2 Pseudonocardia-dioxanivorans-strain-ATCC-55486_F4D1P4Gryllotalpicola-sp-2DFW10M-5_A0A387BSJ7 Streptomyces-sp-NL15-2K_A0A401M8X4Streptomyces-sp-DSM-15324_A0A101UB38Streptomyces-turgidiscabies-Car8_L7F4K9Streptomyces-sp-Root369_A0A0Q6WT15Streptomyces-bungoensis_A0A124I5G8Streptomyces-sp-32146_A0A1M6C784Streptomyces-sp-11212_A0A2G6ZH96Streptomyces-sp-BK022_A0A4Q7YIK6Streptomyces-sp-yr375_A0A1H9A041Streptomyces-lasaliensis_A0A4U5WN09Streptomyces-sp-BK161_A0A4R7HTL8Streptomyces-sp-BK561_A0A4R7AIH9Streptomyces-sp-74_A0A497VKJ5 Streptomyces-longwoodensis_A0A101R2K2Streptomyces-sp-Root264_A0A0Q8Z7G5Streptomyces-griseoruber_A0A101SMK9Streptomyces-sp-75_A0A3D9NEA1Streptomyces-sp-70_A0A2G7F248Streptomyces-sp-Ag82_A0A3N4T213 Streptomyces-sp-OK885_A0A2N4A3M6Streptomyces-sp-OK228_A0A2C8XKL0Streptomyces-sp-BK335_A0A4R3IQB1Streptomyces-mirabilis_A0A1I2HHZ0Streptomyces-sp-93_A0A2G7C8U4Streptomyces-sp-32133_A0A1H5MU02Streptomyces-sp-94_A0A2G7ACS5Streptomyces-bungoensis_A0A117RC48Streptomyces-sp-1-11_A0A510T9H0 Actinobacteria-bacterium-OK006_A0A0N0MW30Streptomyces-olivochromogenes_A0A250V5M7 Streptomyces-sp-BK340_A0A559VBH0Streptomyces-sp-Ag109_A0A286HK82 Candidatus-Accumulibacter-sp-BA-93_A0A011PM30 Streptomyces-sp-Ru72_A0A2S4YGM2 Thauera-terpenica-58Eu_S9Z9D6 Streptomyces-diastatochromogenes_A0A233SGY9Streptomyces-seoulensis_A0A4P6U1T3Streptomyces-incarnatus_A0A0G3AC50Streptomyces-rochei_A0A510CYS3Streptomyces-sp-San01_A0A3S2WI59 Streptomyces-griseoluteus_A0A4Z1DP51Streptomyces-puniciscabiei_A0A542T080Streptomyces-puniciscabiei_A0A1D7Y5G8Streptomyces-sp-MMG1121_A0A0M8VBB4Streptomyces-sp-FXJ1172_A0A176KW97Streptomyces-sp-IMTB-2501_A0A1R0LXV1Streptomyces-sp-MUSC-1_A0A1S2QAK0Streptomyces-sp-MUSC-14_A0A1S2Q1J2Streptomyces-sp-F-1_A0A1K2FNA8Streptomyces-sp-BK141_A0A4R7HLF7Streptomyces-sp-32124_A0A495H6G2Streptomyces-cellostaticus_A0A124HDX3 Sphingobacteriaceae-bacterium_A0A3D3PD59 Streptomyces-yokosukanensis_A0A124HF87Streptomyces-griseofuscus_A0A3R8SBF8Streptomyces-griseofuscus_A0A1X4GY56Streptomyces-sp-DconLS_A0A1C5E823Streptomyces-sp-S816_A0A4S2IV43Streptomyces-misionensis_A0A5C6ITU9Streptomyces-sp-BK308_A0A4R3CJA0Saccharothrix-sp-ST-888_A0A0F0HUX2 Eoetvoesia-caeni_A0A366H0N4 Streptomyces-griseochromogenes_A0A1B1AW81Streptomyces-malaysiense_A0A1J4PWD0Streptomyces-sp-NRRL-F-5122_A0A0X3S728Streptomyces-sp-Ag109_A0A3N4S225Streptomyces-sp-BK674_A0A4R3DYC3Streptomyces-sp-Ag109_A0A1H5HQY5Streptomyces-sp-BK329_A0A4R3B8H0Streptomyces-sp-CdTB01_A0A0U3QGN9Streptomyces-sp-32124_A0A495HRW1Streptomyces-canus_A0A117QWI8Arthrobacter-sp-JH1-1_A0A4R5KR47Streptomyces-sp-8445_A0A3N1L4K1Streptomyces-sp-8465_A0A4R7MPI6 Streptomyces-sp-PsTaAH-130_A0A327UG69Streptomyces-lavendulae_A0A5C8GZL1Streptomyces-sp-NRRL-B-3648_A0A0N0TCT1Streptomyces-curacoi_A0A124H684Streptomyces-pluripotens_A0A221NU68Streptomyces-sp-BK387_A0A4R2D6I3Streptomyces-sp-Z022_A0A3G2JNI4Streptomyces-sp-JV178_A0A2G9DX78Kitasatospora-sp-OK780_A0A2N0JJE0Streptomyces-gilvosporeus_A0A1V0TWE0 Candidimonas-bauzanensis_A0A1M6BT12 Streptomyces-sp-A1136_A0A4S2SLP2Arthrobacter-sp-24S4-2_A0A4P8GLE5 Burkholderiaceae-bacterium_A0A522LCN2 Streptomyces-swartbergensis_A0A243SB53Streptomyces-variegatus_A0A0M2GKL8Streptomyces-sp-Go-475_A0A2Z5K6R0Streptomyces-sp-BK205_A0A4R3BKB7Streptomyces-sp-GGCR-6_A0A3Q9C6G1Streptomyces-sp-CB01635_A0A2M9JZC9Streptomyces-sp-BK205_A0A4R3BKC8Kitasatospora-atroaurantiaca_A0A561EI59Arthrobacter-sp-PAMC25564_A0A4V1CNI7Actinobacteria-bacterium_A0A3D5DLL7Streptomyces-sp-NEAU-C40_A0A4U0SMQ0Amycolatopsis-vastitatis_A0A229SM19 Streptomyces-spinoverrucosus_A0A4Y3VXI1Streptomyces-mangrovisoli_A0A1J4NT24Streptomyces-sp-DSM-15324_A0A101UGV9Kutzneria-buriramensis_A0A3E0HIM8Streptomyces-sp-ICBB-8177_A0A2U3BWD2Amycolatopsis-saalfeldensis_A0A1H8S9M2 Sulfuricella-sp-T08_A0A0E9MD93Oxalobacteraceae-bacterium_A0A3D3PKH4 Streptomyces-roseochromogenus-subsp-oscitans-DS-12976_V6KT51Streptomyces-sp-NRRL-B-3648_A0A0M8WU77Streptomyces-sp-NRRL-WC-3618_A0A0M8W2W3Streptomyces-griseorubiginosus_A0A385ZRS4Goodfellowiella-sp-AN110305_A0A5B2XR11Pseudonocardiales-bacterium_A0A2W6DT93Kutzneria-sp-744_W7TCW2 Oxalobacteraceae-bacterium_A0A3D1J185Burkholderiaceae-bacterium_A0A522ZYX4 Streptomyces-collinus-strain-DSM-40733--Tu-365_S5VCT9Streptomyces-sp-VMFN-G11Ma_A0A2T5B0E8Streptomyces-natalensis-ATCC-27448_A0A0D7CDH0 mine-drainage-metagenome_A0A1J5S169 Streptomyces-chartreusis-NRRL-3882_A0A2N9BLL2Streptomyces-griseorubiginosus_A0A3N1MG93 Syntrophorhabdus-sp-PtaU1Bin058_A0A1V5CPJ9Sulfuricella-denitrificans-strain-DSM-22764_S6ABH3Paenibacillus-baekrokdamisoli_A0A3G9JDF4 Kitasatospora-sp-MMS16-BH015_A0A2H5B9J9 Paenibacillus-sp-GP183_A0A1H4RW49 Actinobacteria-bacterium-OK074_A0A0N1FXJ1Kutzneria-buriramensis_A0A3E0GU04 Candidatus-Accumulibacter-phosphatis_A0A369XJR6Collimonas-arenae_A0A127PQL6 Moraxellaceae-bacterium-HYN0046_A0A345PA29 Amycolatopsis-balhimycina-DSM-5908_A0A428VYH2 Halothiobacillus-sp-20-54-6_A0A257NY81 Anoxybacillus-amylolyticus_A0A167TNQ9 Halothiobacillus-sp-28-55-5_A0A258QAG9 Halothiobacillus-sp-20-53-49_A0A257QD05Halothiobacillus-sp-24-54-40_A0A259B7I7 Hydrogenophilales-bacterium-RIFOXYA1_A0A1G0QCK8Sulfurirhabdus-autotrophica_A0A4R3Y1H8 Pseudomonas-sp-SJZ079_A0A560Q651Pseudonocardiales-bacterium_A0A2W6CIF7Pseudonocardiales-bacterium_A0A2W6FXE2 Pseudomonas-pohangensis_A0A1H2E2K2 Halothiobacillus-sp-LS2_A0A191ZKJ2

mine-drainage-metagenome_A0A1J5PW63 Catenulispora-acidiphila-strain-DSM-44928_C7Q3V3 marine-sediment-metagenome_A0A0F9TUJ6Acidimicrobiales-bacterium_A0A2W6BHN2Streptomyces-sp-NEAU-C40_A0A4U0SBH0 Pseudonocardiales-bacterium_A0A2W6E6D4 Bacillus-sp-FJAT-26390_A0A1B8WLQ4 Desulfosporosinus-acididurans_A0A0J1FRG6Desulfosporosinus-acidiphilus-strain-DSM-22704_I4DB68Streptosporangium-subroseum_A0A239LT57

Pseudomonas-sp-J237_A0A1E5XCX2Rhodococcus-sp-C1-24_A0A5A7S2T8 Klenkia-soli_A0A1H0IRI7 Pseudomonadaceae-bacterium_A0A2E8INR2

Streptomyces-sp-MMG1121_A0A0M9ZJ96 Polynucleobacter-sp-35-46-207_A0A258QXW5Polynucleobacter-sp-39-45-136_A0A259PKV1 Collimonas-pratensis_A0A127QZB8 Streptomyces-yunnanensis_A0A1M7KVS5 Polynucleobacter-sp-35-46-11_A0A258LPS0Bordetella-sp-SCN-67-23_A0A1E3ZFB9 Streptomyces-albulus-PD-1_X0NGX6 Bradyrhizobium-erythrophlei_A0A1M5HS95Paraburkholderia-insulsa_A0A2T1ASW0 Pseudomonas-sp-H32019_A0A558FKB2Burkholderia-cepacia_A0A2X2QDF6Paraburkholderia-tropica_A0A1A5X2B1 Aeromonas-jandaei_A0A3N6XQD7Aeromonas-caviae_A0A3G9I2M1Herbaspirillum-robiniae_A0A246WMQ5 Streptomyces-mobaraensis-NBRC-13819-=-DSM-40847_M3B713 Paraburkholderia-fungorum_A0A2N8Q9F7Paraburkholderia-ginsengiterrae_A0A1A9MWJ2Collimonas-sp-OK242_A0A1H2YRN9Pseudomonas-frederiksbergensis_A0A1J0ESG1Paraburkholderia-sp-CNPSo-3008_A0A4R5LA51Burkholderia-sp-LA-2-3-30-S1-D2_A0A1B4F7N2Aquabacterium-sp-NJ1_A0A0A0DP60Herbaspirillum-sp-GW103_I3CVH5Cupriavidus-pauculus_A0A2N5CCA0 Betaproteobacteria-bacterium_A0A2W4UEX3Enterobacter-sp-DC4_W7PI54Collimonas-pratensis_A0A127Q4N8Skermania-sp-ID1734_A0A554V8R6 Methylovirgula-sp-4M-Z18_A0A371WNL0Bradyrhizobium-sp-DFCI-1_U1IIR9 Pseudomonas-brassicacearum_A0A423H153Burkholderia-sp-TJI49_F0G067Burkholderia-contaminans_A0A2S9NAU8Burkholderia-cenocepacia_A0A088UI12Burkholderia-pseudomultivorans_A0A132ETR4 Microbacterium-hominis_A0A2K9DCL9Microbacterium-hominis_A0A134DHS9 Paracoccus-aminovorans_A0A1I3E327 Bradyrhizobium-sp-UFLA03-84_A0A2A2VIU0Paraburkholderia-sp-BL21I4N1_A0A2S8RZP0 Pseudomonas-fluorescens_A0A0N9VYR9Pseudomonas-fluorescens-HK44_A0A010SJ18Burkholderia-sp-IDO3_A0A2A4C2S9Burkholderia-sp-AU4i_U2GC90Burkholderiales-bacterium_A0A431K8K2Burkholderiales-bacterium-66-26_A0A1Q3YC09 Pandoraea-sp-LMG-31012_A0A5E4YCV0 Streptosporangium-nondiastaticum_A0A2P7PXH9 Bradyrhizobium-macuxiense_A0A560LYB2Methylobacterium-dankookense_A0A564G004 Burkholderia-vietnamiensis_A0A132DL26 Microbacterium-sp-SCN-70-200_A0A1E4DAM8Streptomyces-rubellomurinus-strain-ATCC-31215_A0A0F2TCP8 Ralstonia-sp-AU12-08_S9RU44Citrobacter-freundii_A0A2L1KPB7Salinisphaera-sp-LB1_A0A2Z3J451Paracraurococcus-sp-NE82_A0A4R4DIS9 Bradyrhizobium-lablabi_A0A1M7G4R8Paraburkholderia-fungorum_A0A3R7EW94 Pseudomonas-brassicacearum_A0A423H7J3Burkholderia-cenocepacia_A0A1V6KWT4Herbaspirillum-sp-CF444_J2UAH2Herbaspirillum-aquaticum_A0A225SWT4Herbaspirillum-seropedicae_A0A5B8E459Mitsuaria-sp-7_A0A1A9HHP4 Microbacterium-laevaniformans_A0A4S2D722 Amnibacterium-kyonggiense_A0A4R7FT35 Streptomyces-eurocidicus_A0A2N8NTX2 Bradyrhizobium-sp-NAS962_A0A1Q5RQA3Methylorubrum-populi-strain-ATCC-BAA-705_B1ZCG7Methylobacterium-aquaticum_A0A0C6FQT1Methylobacterium-brachiatum_A0A3G2VA01Paraburkholderia-fungorum_A0A1H1ILU6Ralstonia-solanacearum-CMR15_D8NFR5Burkholderia-cepacia_A0A3P0WDL4Burkholderia-cenocepacia_A0A1V2XL01Pelomonas-saccharophila_A0A4V2VQ04 Paracoccus-aminophilus-JCM-7686_S5XUM5 Methylobacterium-sp-GXS13_A0A0V7Z5U0Methylobacterium-currus_A0A2R4WS11 Ralstonia-sp-A12_A0A0B1YEU1Paraburkholderia-sartisoli_A0A1H4HD21Thiomonas-sp-Sup16B3_A0A5Q4XR14 Streptomyces-sp-Ag109_A0A3N4SLN0 Methylobacterium-sp-UNCCL125_A0A1I7K5N9Ralstonia-solanacearum-strain-GMI1000_Q8XTJ4Pseudomonas-sp-655_A0A0M9AXL7Pseudomonas-frederiksbergensis_A0A423JNJ0Pseudomonas-sp-ERMR1_A0A270PBE7Pseudomonas-moorei_A0A1H1DL69Chromobacterium-sp-ATCC-53434_A0A2H5DSF4Burkholderiales-bacterium-66-5_A0A1M3BZ39Simplicispira-sp-NY-02_A0A398CGT2Roseateles-aquatilis_A0A2D0ALP5 Microbacterium-hominis_A0A0B4C8W4Microbacterium-sp-PM5_A0A2Z5BQY3 Kitasatospora-sp-MMS16-CNU292_A0A540W645 Shewanella-livingstonensis_A0A3G8LRG7Paraburkholderia-insulsa_A0A2T1AAT8 Bradyrhizobium-centrolobii_A0A176YBR7Bradyrhizobium-neotropicale_A0A176ZK12Afipia-sp-1NLS2_D6V1J8Ralstonia-solanacearum_A0A5B7U8S7Ralstonia-solanacearum_A0A347CZZ4 Herbaspirillum-sp-VT-16-41_A0A1V2VAF5 Clavibacter-michiganensis-subsp-chilensis_A0A399TN27 Psychrobacter-sp-DAB_AL32B_A0A229G4N2Ralstonia-sp-MD27_A0A0J9DQP3Thiomonas-sp-13-64-67_A0A259RFB1 Bradyrhizobium-sp-G22_A0A160UZT0Methylobacterium-sp-yr596_A0A1I2HIE0Ralstonia-solanacearum_A0A0S4TV59blood-disease-bacterium-R229_G2ZXM6blood-disease-bacterium-A2_A0A1U9VQA4Ralstonia-solanacearum-UW551_A3RSR8Ralstonia-sp-MD27_A0A0J9DSS1Pseudomonas-sp-ANT_A0A5B0ES46Pseudomonas-sp-DP16D-R1_A0A2K4L0F2Pseudomonas-sp-ACM7_A0A4V0YM77Pseudomonas-gingeri-NCPPB-3146-=-LMG-5327_A0A2K1F7Z7 Burkholderiales-bacterium_A0A3S0KQF0 Hydrogenophilales-bacterium-17-61-76_A0A259G9K8 Methylobacterium-sp-WL1_A0A5B9F0J8Ralstonia-solanacearum_A0A1C0UE48Ralstonia-sp-AU12-08_S9S4K1Pseudomonas-sp-LAB-08_A0A1B4WX60Burkholderiaceae-bacterium_A0A522S6I3 Microbacterium-sp-AG790_A0A495RS73 Ralstonia-insidiosa_A0A192A1D8 Streptomyces-incarnatus_A0A0G3AFE6 Paracoccus-sp-TK008_A0A5C6S6U0 Bradyrhizobium-japonicum_A0A0A3XSN2Methylobacterium-sp-ARG-1_A0A0L6JA52Ralstonia-solanacearum-strain-Po82_F6G776Ralstonia-solanacearum_A0A399VYD7Ralstonia-sp-SET104_A0A401K1W3Pseudomonas-mohnii_A0A1H5BTD4 Clavibacter-michiganensis-subsp-phaseoli_A0A399TN98 Collimonas-fungivorans-strain-Ter331_G0ABU9Gordonia-sp-NB4-1Y_M7A6R4Rhodococcus-enclensis_A0A2A5JGW9 Bradyrhizobium-sp-LTSP885_A0A0D7P431Methylobacterium-radiotolerans_A0A438LLZ7Paraburkholderia-sp-BL9I2N2_A0A4R1MI36Ralstonia-solanacearum-CFBP2957_D8P750Ralstonia-insidiosa_A0A192A6E1Pelomonas-saccharophila_A0A4R3ULU7Pseudomonas-batumici_A0A0C2I3P4Paraburkholderia-tropica_A0A2V3X9C0 Psychrobacter-sp-DAB_AL43B_A0A1U6GMH2 Streptomyces-sp-MZ03-48_A0A553Z6C8 Paracoccus-sp-SC2-6_A0A344PJC1 Bradyrhizobium-sp-MOS001_A0A4Y9V0Z8Bradyrhizobium-cytisi_A0A5S4WP86Ralstonia-solanacearum_A0A5H2PQ40Ralstonia-solanacearum_A0A177RF51 Amnibacterium-setariae_A0A3A1U647 Paracoccus-sulfuroxidans_A0A562NQ73 Bradyrhizobium-erythrophlei_A0A1M5R077Bradyrhizobium-sp-LTSPM299_A0A0D7QCR2Methylobacterium-sp-GXS13_A0A0V7Z9D0 Pseudomonas-sp-ANT_A0A5B0F7T6Pseudomonas-asplenii_A0A438KYN1 Bradyrhizobium-guangzhouense_A0A4Q0RLV3 Pseudomonas-protegens-strain-DSM-19095--LMG-27888--CHA0_A0A2C9ES19 Acetobacteraceae-bacterium-DB1506_A0A327LXP1 Pseudomonas-caspiana_A0A502J0Q3Pseudomonas-arsenicoxydans_A0A4P6G683Pseudomonas-fluorescens-strain-ATCC-BAA-477--NRRL-B-23932--Pf-5_Q4K7Q1Pseudomonas-sp-MWU12-2534b_A0A365VP11Pseudomonas-sp-MWU12-2534b_A0A365VXM7 Curtobacterium-sp-Ferrero_A0A2A5NN35Curtobacterium-sp-MCBD17_A0A2W1YMD3 Aeromonas-sp-HMWF017_A0A2R7NEV5Thiomonas-sp-14-64-326_A0A259RUM9Thiomonas-sp-SCN-64-16_A0A1D2UPL2Williamsia-sp-1138_A0A261D564 Bradyrhizobium-arachidis_A0A1I7KYS2 Pseudomonas-brassicacearum_A0A423J7Q8Pseudomonas-arsenicoxydans_A0A1H0MVN9Pseudomonas-putida_A0A2Z4RCH7Pseudomonas-sp-TKO29_A0A2W0FQG6 Microbacterium-laevaniformans_A0A4S2D956Microbacterium-sp-SCN-69-37_A0A1E4C880Curtobacterium-sp-MCBA15_A0A1S2GT24Curtobacterium-sp-MCBA15_A0A1S2HKV2 Buttiauxella-sp-B2_A0A5C5DCW7Rhodococcus-sp-1168_A0A1X0UMJ2Rhodococcus-sp-1163_A0A1X0UL92Gordonia-phthalatica_A0A0N9NDG6 Bradyrhizobium-rifense_A0A5D3KLA3 Streptomyces-cattleya-strain-ATCC-35852--DSM-46488--JCM-4925--NBRC-14057--NRRL-8057_F8JYL8Actinobacteria-bacterium-HGW-Actinobacteria-5_A0A2N3FRU5Curtobacterium-sp-MMLR14_A0A1S2JL69Curtobacterium-sp-MCLR17_A0A2W1VXP3 Paraburkholderia-fungorum_A0A2N8QGW1Thiomonas-intermedia-strain-K12_D5X6T8Gordonia-sp-RS15-1S_A0A3N4GAC9Rhodococcus-qingshengii_A0A069JFL8Rhodococcus-kyotonensis_A0A239H4H7Tsukamurella-pseudospumae_A0A138ABG7 Bradyrhizobiaceae-bacterium-PARB1_A0A257KV12 Pseudomonas-sp-NFPP09_A0A1K1W7X2Pseudomonas-sp-AU11447_A0A1B8V1R9 Curtobacterium-sp-KBS0715_A0A554N3I7Curtobacterium-sp-MCLR17_A0A2W1TXY3Microbacterium-testaceum_A0A147F8Q3Leifsonia-sp-SCN-70-46_A0A1E4M8W4 Yokenella-regensburgei_A0A484WXU2Yokenella-regensburgei_A0A2X2QHU9Klebsiella-oxytoca_A0A168XZA3 Paraburkholderia-dipogonis_A0A4Y8MQH5Pseudomonas-sp-GM48_J2S053Pseudomonas-koreensis_A0A436ZG47Pseudomonas-sp-NFPP22_A0A2T0ZHE1 Devosia-sp-67-54_A0A1Q3YY81 Thiomonas-bhubaneswarensis_A0A0K6HXG7Rhodococcus-erythropolis-SK121_C3JVE2 Pseudomonas-abietaniphila_A0A1G8GT66Pseudomonas-kribbensis_A0A4Y8VH62Pseudomonas-kribbensis_A0A345RPH2Pseudomonas-sp-91RF_A0A399PPA4Pseudomonas-vancouverensis_A0A1H2N432Pseudomonas-fluorescens_A0A0P8ZBK9Pseudomonas-sp-GM55_J3B5U3 Williamsia-sp-Leaf354_A0A0Q5R355 Pseudomonas-syringae-pv-aceris_A0A3M5BI01Pseudomonas-sp-strain-GM412012_W6V6C0Pseudomonas-sp-GM49_J3GA75Pseudomonas-fluorescens_A0A327N3K9Pseudomonas-jessenii_A0A2W0ENV4Pseudomonas-antarctica_A0A1H0CJC7 Pseudomonas-sp-OV144_A0A4R7U248 Shewanella-frigidimarina-strain-NCIMB-400_Q07W90Enterobacter-sp-BIDMC92_A0A0J1VEN0Raoultella-planticola_A0A443VKL1Gordonia-sp-MMS17-SY073_A0A3G8JNP9 Pseudomonas-arsenicoxydans_A0A502HJD1Pseudomonas-sp-OV226_A0A2V2ANB3Pseudomonas-mandelii-PD30_A0A059KX81Pseudomonas-fluorescens_A0A2A5R9M3Pseudomonas-sp-GV041_A0A2T5SQE3Pseudomonas-fluorescens_A0A0F4T5F4 Amnibacterium-kyonggiense_A0A4R7FPT4 Terrabacter-sp-Root85_A0A0Q8Y823Terrabacter-sp-Soil811_A0A0Q9UHL9Pseudomonas-sp-C9_A0A1V3MDJ2Pseudomonas-brassicacearum_A0A423IGI8Pseudomonas-mandelii_A0A5C5QTF1Pseudomonas-caspiana_A0A502J691 Buttiauxella-sp-A111_A0A4P5Q6B7 Tessaracoccus-antarcticus_A0A3M0FWN0Pseudomonas-fluorescens_A0A0F4UXV5Pseudomonas-sp-ANT_A0A5B0BJG8Pseudomonas-sp-K2I15_A0A246G4P3Pseudomonas-deceptionensis_A0A0J6J364Pseudomonas-fragi_A0A266LQ65Pseudomonas-corrugata_A0A3M3ENK3 Gordonia-sputi-NBRC-100414_H5U6I7 Micromonospora-sp-KC207_A0A4R4RI39Terrabacter-aerolatus_A0A512CZF7Pseudomonas-sp-SHC52_A0A0A1HPW1Pseudomonas-yamanorum_A0A143GL87Pseudomonas-yamanorum_A0A1H2EQW8 Rhodococcus-sp-PAMC28705_A0A4P7RPX5 Micromonospora-olivasterospora_A0A562I889Pseudomonas-syringae-group-genomosp-3_A0A2S3TMZ3Pseudomonas-avellanae_A0A261WIW1Pseudomonas-sp-NFACC25_A0A1G4WLW9Pseudomonas-sp-HMWF021_A0A2R7MSS1Pseudomonas-sp-AD21_A0A2N7R685Pseudomonas-brassicacearum_A0A423IG50Pseudomonas-sp-ok266_A0A1H8TYK8 Pantoea-rodasii_A0A0B1R8V0 Pseudomonas-syringae-pv-actinidiae-ICMP-19497_A0A0W0PE99Pseudomonas-syringae-pv-actinidiae_A0A454G074Pseudomonas-avellanae_A0A2S3TAL3Pseudomonas-sp-ES3-33_A0A0D9A3R2Pseudomonas-sp-RD25_A0A5R8R245Pseudomonas-sp-OV286_A0A2V5BLS1Pseudomonas-sp-2995-3_A0A2G5NVT8Pseudomonas-fluorescens-ICMP-11288_A0A0W0HLM1Pseudomonas-sp-S150_A0A482NLJ1Pseudomonas-sp-GM30_W6VQY0Pseudomonas-jessenii_A0A5C4KXB1 Mangrovibacter-phragmitis_A0A1B7KYA2 Asanoa-ferruginea_A0A3D9ZVA4Friedmanniella-sagamiharensis_A0A1H2LQM9Pseudomonas-sp-21_A0A0F0DJ10Pseudomonas-reinekei_A0A1H0PCI3Pseudomonas-sp-ICMP-8385_A0A2G0YFZ1Pseudomonas-versuta_A0A0M4Q8P2Pseudomonas-sp-Leaf98_A0A327GIZ0Pseudomonas-fragi_A0A267AIM6Pseudomonas-fluorescens-NCIMB-11764_A0A0K1QHU9Pseudomonas-sp-FSL-W5-0299_A0A1S8GSE2Pseudomonas-fluorescens_A0A423MQU3Pseudomonas-extremaustralis_A0A5M9ITE4Pseudomonas-sp-HMWF005_A0A2R7TIX9 Pantoea-dispersa_A0A518XJP0Kroppenstedtia-sanguinis_A0A482TS63 Pseudomonas-poae_A0A423EQI0Pseudomonas-sp-BCA17_A0A5R1QBW6Pseudomonas-azotoformans_A0A1V2JND5Pseudomonas-palleroniana_A0A0X7K271Pseudomonas-palleroniana_A0A1H5PBN0 Yokenella-regensburgei-ATCC-43003_G9Z4Y9Raoultella-ornithinolytica_A0A1Y6GLB6 Pseudomonas-costantinii_A0A1S2ULI0Pseudomonas-extremaustralis_A0A5C5Q9Q3Pseudomonas-fluorescens_A0A0W0H9C1 Actinoplanes-awajinensis-subsp-mycoplanecinus_A0A101JRJ6Pseudomonas-nabeulensis_A0A4Z0AJE2Pseudomonas-sp-SXM-1_A0A4P7B2M5Pseudomonas-sp-AP19_A0A1E4XCX3 Curtobacterium-sp-UNCCL20_A0A1H1FQ28 Pseudomonas-poae_A0A3S9JYD3Pseudomonas-sp-KBW05_A0A3N7AYV1Pseudomonas-sp-GV058_A0A2V4YM42Pseudomonas-sp-AP19_A0A1E4XEP9Pseudomonas-sp-GW704-F2_A0A2N7YP23Pseudomonas-sp-ok602_A0A1I4WQ22 Enterobacter-lignolyticus-strain-SCF1_E3G8F0 Pseudomonas-sp-PGPPP1_A0A257E1H1Pseudomonas-veronii-1YdBTEX2_A0A1D3K6T0Pseudomonas-sp-TMW-21634_A0A494RF36 Enterobacter-sp-CC120223-11_A0A285K142Thiomonas-arsenitoxydans-strain-DSM-22701_D6CMW0Gordonia-neofelifaecis-NRRL-B-59395_F1YEE8 Pseudomonas-knackmussii-strain-DSM-6978--LMG-23759--B13_A0A024HH47 Sphaerisporangium-album_A0A367FHU8 Brachybacterium-sp-SGAir0954_A0A4P8TMB7Actinoplanes-sp-strain-ATCC-31044_G8SHL8

Pantoea-rwandensis_A0A1X1D4Y0 Arthrobacter-alpinus_A0A0S2LZ00 Pseudomonas-putida_A0A1B2FEY1 Knoellia-locipacati_A0A512T096 Deinococcus-sp-H1_A0A553V6T1 Pantoea-sp-YR343_J3HCX9 Arthrobacter-sp-S41_A0A4Q8TLG8 Pantoea-cypripedii_A0A1X1ELK8Enterobacter-cancerogenus_A0A0A3YQH1 Pseudomonas-putida_A0A2S3WZI9 Nocardioides-sp-LS1_A0A401Y5H7Phycicoccus-sp-Root563_A0A0T2IKB9 Micromonospora-globispora_A0A317KCR4 Deinococcus-sp-S14-83_A0A3G8YMN6 Deinococcus-aerius_A0A2I9DII8 Actinomadura-syzygii_A0A5D0UCQ0 Marmoricola-scoriae_A0A1H1P0D5Knoellia-sp-Soil729_A0A0Q9KPD5Janibacter-sp-HTCC2649_A3TGW6 Streptomyces-sp-70_A0A2G7F980 Phytophthora-ramorum_H3GAE5Phycicoccus-bigeumensis_A0A502D0H3 Pseudomonas-sp-RV120224-01b_A0A2V5EIL7Pseudomonas-sp-StFLB209_A0A077LCU5 Phytophthora-ramorum_H3GAY2 Acrocarpospora-macrocephala_A0A5M3WJU4 Phytophthora-kernoviae_A0A421FP61Nocardioides-sp-CF479_A0A495MUU6Frankia-sp-B2_A0A4Y8M9V4 Streptomyces-sp-MZ04_A0A4V3J825 Pseudomonas-putida-H8234_R9VAV7 Pantoea-sp-strain-At-9b_E6WJ93 Nocardioides-currus_A0A2R7Z034Marmoricola-pocheonensis_A0A3N0GND6Pseudonocardiales-bacterium_A0A2W6DSZ6 Streptomyces-sp-Ag82_A0A3D9W746 Pseudomonas-sp-CC120222-01a_A0A315T5K3 metagenome_A0A2P2C2Q1 Micromonospora-sp-MP36_A0A5D0V087 Streptomyces-sp-94_A0A2G7AF48 Deinococcus-phoenicis_A0A016QRJ3 Deinococcus-marmoris_A0A1U7P368 Streptomyces-cellostaticus_A0A101NQE2 Deinococcus-sp-AJ005_A0A5J6YRC9 Streptomyces-mirabilis_A0A1I2KE74 Frankia-canadensis_A0A2I2KWU8 Streptomyces-sp-32125_A0A397MNJ9 Frondihabitans-australicus_A0A495IE04 Deinococcus-sp-H1_A0A553UH20 Janibacter-limosus_A0A4P6MXP0 Streptomyces-sp-F-1_A0A1K2FX93 Oenococcus-oeni_A0A483BUA9 Micromonospora-narathiwatensis_A0A1A9A732 Frankia-sp-BMG536_A0A1S1RN30 Micromonospora-sp-CB01531_A0A1Q5B3R1 Streptomyces-canus_A0A117QWI0 Kitasatospora-setae-strain-ATCC-33774--DSM-43861--JCM-3304--KCC-A-0304--NBRC-14216--KM-6054_E4N5F2 Nocardioides-sp-Root122_A0A0Q6UT60Terrabacter-aerolatus_A0A512D6R1 Gaiella-sp-SCGC-AG-212-M14_A0A177RAT5 Streptomyces-sp-yr375_A0A1H9SQG7 Frankia-sp-BMG523_A0A062WN16 Bacillus-sp-ALD_A0A371TJT6Bacillus-sp-ALD_A0A371SNZ8 Nocardioides-szechwanensis_A0A1H0J863 Nocardioides-psychrotolerans_A0A1I3PD59 Bacillus-sp-LF1_A0A0U1NS19 Nakamurella-silvestris_A0A399UM75 Streptomyces-sp-M56_A0A2K8RF73 Phytophthora-megakarya_A0A225WL75 Streptomyces-sp-32122_A0A2U0X4N3Streptomyces-seoulensis_A0A4P6TR67 Acidimicrobiaceae-bacterium_A0A539DRJ7 Gordonia-polyisoprenivorans-strain-DSM-44266--VH2_H6MWM7Frankia-alni-strain-ACN14a_Q0RC47 Bacillus-cereus_A0A2A8R8J9Bacillus-cereus_A0A2B1KRX6 Streptomyces-sp-OK885_A0A2N4A0T1 Key Deinococcus-sp-KSM4-11_A0A4S4CEH2 Phytophthora-sojae-strain-P6497_G4ZU16 Bacillus-cereus_A0A2A9U3X6 Streptomyces-sp-CB01635_A0A2M9JMA0 Streptomyces-sp-SA15_A0A2A2Z953 Gordonia-polyisoprenivorans-NBRC-16320-=-JCM-10675_H0RJ57 Bacillus-simplex_A0A3R8MFA2 Frankia-sp-R43_A0A0P7CNE3 Oenococcus-sicerae_A0A410NBP5 Bacillus-mycoides_A0A443T7X8Bacillus-cucumis_A0A2N5HFK0Aneurinibacillus-soli_A0A0U4WJH9 Amnibacterium-kyonggiense_A0A4R7FPP3 Bacillus-simplex_A0A127D861Bacillus-sp-WN066_A0A4R5VJU6Bacillus-sp-WN066_A0A4R5VWX9Bacillus-sp-SAJ1_A0A432E2N9 Streptomyces-sp-BK387_A0A4R2D825

Nocardioides-sp-HLT2-9_A0A4Q2T6K9Deinococcus-sp-Arct2-2_A0A4S4BDN6 Streptomyces-sp-PRh5_A0A014N1C4 Streptomyces-sp-MUSC-93_A0A1S2PKG2 Bacillus-mesonae_A0A3Q9QZW2 Streptomyces-autolyticus_A0A1P8XR58 Bacillus-sp-WN066_A0A4R5VI64Bacillus-sp-WN066_A0A4R5VHT7Bacillus-sp-BK006_A0A4R2A7N9 Streptomyces-sp-JV178_A0A2G9DXE2 Frankia-sp-CcI49_A0A1V2KSU3 Bacillus-sp-OV166_A0A1Y6G8Y4Bacillus-sp-OK838_A0A239IDU7Bacillus-sp-AFS018417_A0A2A8SLG2 Streptomyces-sp-32123_A0A3D9QRT0Streptomyces-sp-BK308_A0A4R3BYE6

Bacillus-sp-Leaf13_A0A0Q6HCX4 Streptomyces-sp-OK228_A0A2C8WYW6 Nocardioides-psychrotolerans_A0A1I3R8Y3 Bacillus-sp-OV166_A0A1Y6FW29 CCMP2097-genomic_454831 Kribbella-jejuensis_A0A542E8F8 Paenibacillus-sp-N34_A0A5C8LKJ9 Nocardioides-bacterium_A0A4S5ANV5 Streptomyces-malaysiensis_A0A291SKQ4 Bacillus-sp-FJAT-25496_A0A5B8Z5A3 Pimelobacter-sp-strain-R48_A0A2E0MKU7 Nocardia-stercoris_A0A3M2L2R8 Frankia-irregularis_A0A0S4QM32 Streptomyces-acidiscabies_A0A0L0JDS0 Bacillus-sp-MUM-116_A0A1S2QW34Bacillus-megaterium_A0A4U0LYD7Paenibacillus-ferrarius_A0A1V4HID9Desulfotomaculum-guttoideum_A0A1I0JJI0 Streptomyces-sp-FXJ1172_A0A176L821 Streptomyces-violaceusniger_A0A0X3VRJ4 Mycobacterium-sp-JS623_L0J3V3 Desulfosporosinus-sp-OT_G2FL49 Streptomyces-acidiscabies_A0A100J2F9

Paenibacillus-taihuensis_A0A3D9SCJ2 Streptomyces-violaceusniger_A0A4D4KQT5 Labedaea-rhizosphaerae_A0A4R6SGM5 Paenibacillus-sp-A59_A0A0M9BP14Bacillus-sp-Soil768D1_A0A0Q9V2F7Pseudonocardia-sp-73-21_A0A1Q4D7F4 Paenibacillus-sp-BK736_A0A4R3C9X1 Streptomyces-griseochromogenes_A0A1B1AXF4 Mycobacterium-sp-JS623_L0J8B9Rhodococcus-sp-LP_A0A4R6X526Rhodococcus-opacus_A0A4V3F9L3 Cohnella-sp-AR92_A0A433RGR5Cohnella-sp-G13_A0A559JNE1Bacillus-pseudomycoides_A0A2C5FGP7Paenibacillus-sp-N34_A0A5C8L0J8 Nocardioides-exalbidus_A0A1H4R120Nocardioides-sp-Root240_A0A0Q8WRI6 Actinobacteria-bacterium_A0A538CXN6 Nocardioides-bacterium_A0A3D0S1N7Bacillus-sp-AFS031507_A0A2C2UVT9Bacillus-sp-NFR08_A0A368WJH0 Amycolatopsis-saalfeldensis_A0A1H8SBI6Nakamurella-sp-s14-144_A0A3G8ZN93 Bacillus-sp-MUM-13_A0A1S2QW00Bacillus-butanolivorans_A0A0M0EXU7Paenibacillus-sp-yr247_A0A1H0REA5 Streptomyces-cellostaticus_A0A101NSU8 CCMP2436-genomic_577981Branchiibius-sp-NY16-3462-2_A0A151BT47Nocardioides-oleivorans_A0A4Q2S253Frankia-inefficax-strain-DSM-45817_E3J6U5Bacillus-sp-AFS076308_A0A2B1SAS3 Streptomyces-olivochromogenes_A0A250V3C0 Paenibacillus-sp-OK076_A0A1H8T8A7Lysinibacillus-sp-YR326_A0A4R7U7L9Actinobacteria-bacterium_A0A3C1DSM8 Bacillus-sp-AFS073361_A0A2B2CB31 Streptomyces-sp-VMFN-G11Ma_A0A2T5B0C4 Cohnella-candidum_A0A3G3JW42 Streptomyces-sp-NRRL-F-5122_A0A0X3RQJ9 Micromonospora-inositola_A0A1C5JTV6Nocardioides-sp-Soil774_A0A0Q9Q008Streptomyces-sp-75_A0A3D9NNI7 Streptomyces-sp-T1317-0309_A0A4R9E5D0 Lactococcus-sp-dk310_A0A5C8K647Oenococcus-oeni-strain-ATCC-BAA-331_Q04GI5 Oceanobacillus-arenosus_A0A3D8PYJ2 Streptomyces-sp-32124_A0A495HR54 Nocardioides-sp-GY-10127_A0A4V4N776Motilibacter-peucedani_A0A420XTJ5Paenibacillus-sp-18JY67-1_A0A3S9A5U2Bacillus-sp-AFS002410_A0A2A7WPQ7Amycolatopsis-niigatensis_A0A2N3WNM2 Mycobacterium-sp-ELW1_A0A5C1RBH2Rhodococcus-sp-C9-5_A0A541BP67Nocardia-sp-CFHS0054_A0A386ZPK4Nocardioides-sp-Root151_A0A0Q7ZQF4Streptomyces-sp-73_A0A2N3U108Motilibacter-rhizosphaerae_A0A4Q7NSL5Desulfosporosinus-sp-BG_A0A1C3FAY6Cohnella-sp-CAU-1483_A0A4U0FCJ6 Arthrobacter-echini_A0A5D0XVG7Microlunatus-soli_A0A1H1Z7M1 Cohnella-candidum_A0A3G3JVZ0Bacillus-sp-FJAT-27238_A0A0K9MG37 Bacillus-sp-AFS017336_A0A2H3NHM6Paenibacillus-sp-BK033_A0A4R1ZYR3Pseudonocardiales-bacterium_A0A2W6CA79 Mycobacterium-sp-EPa45_A0A0G3IRP1Streptomyces-sp-OK228_A0A2C8WYQ6Subtercola-boreus_A0A3E0W3W9 Streptomyces-sp-NRRL-F-5122_A0A0X3RR07 CCMP2298-genomic_456111Intrasporangium-chromatireducens-Q5-1_W9GQB4Rhodococcus-qingshengii_A0A069JFU0Saccharothrix-sp-ST-888_A0A0F0HP26Rathayibacter-sp-AY1B1_A0A2S5YAI4 Paenibacillus-sp-JC52_A0A559JGK3

Streptomyces-roseus_A0A0J7ABD7 Bacillus-sp-AFS077874_A0A2B1GZS6 Actinobacteria-bacterium-OK006_A0A0N1FKU8 Mycobacterium-sp-WY10_A0A1J0U2X3Rhodococcus-sp-C1-24_A0A5A7SA57Rhodococcus-qingshengii_A0A1X0LPJ6Rhodococcus-sp-ACS1_A0A2A3F8D4Subtercola-boreus_A0A3E0W9Q9Pimelobacter-sp-strain-R48_A0A2E0MS86Pseudomonas-sp-SLBN-26_A0A542S6N3Paenibacillus-sp-VT-16-81_A0A1V4G4W9 Mycolicibacterium-hodleri_A0A502DPI7 Bacillus-sp-FJAT-25509_A0A0Q3VYS6Lysinibacillus-sp-SDF0063_A0A544UST8 Streptomyces-sp-NRRL-WC-3618_A0A0M8WE32 Mycobacterium-sp-ENV421_A0A2N8LNR3Streptomyces-sp-FXJ1172_A0A176L8M8Humibacter-sp-BT305_A0A345K2Y8Rathayibacter-sp-PhB127_A0A3N2G0I0Rathayibacter-sp-PhB179_A0A4R1VEU5Streptomyces-sp-MUSC-1_A0A1S2PR32 Bacillus-sp-AFS088145_A0A2A9S4V5Bacillus-sp-AFS053548_A0A2B9B1U9Lysinibacillus-xylanilyticus_A0A0K9FC58Paenibacillus-sp-VKM-B-2647_A0A0C2QJ96 Nocardioides-sp-strain-ATCC-BAA-499--JS614_A1SH30Rathayibacter-sp-AY1F3_A0A2S5XQM6Streptomyces-sp-BK335_A0A4R3J2S1Nocardioides-sp-Root224_A0A0Q8UAW4Bacillus-sp-AFS029533_A0A2C3K4V1Paenibacillus-pectinilyticus_A0A1C1A1F4Paenibacillus-macquariensis_A0A1N7CN62Candidatus-Frankia-californiensis_A0A1C3PAX7 Kribbella-sp-VKM-Ac-2570_A0A4R7ZWY4Rathayibacter-sp-AY1C5_A0A2S5XFK4Nocardioides-sp-HLT2-9_A0A4Q2SKR1Streptomyces-sp-32124_A0A495HT34Streptomyces-sp-JV178_A0A2G9DXU7Marmoricola-solisilvae_A0A3N0DTH1Bacillus-sp-FJAT-25509_A0A0Q3TSU3 Leuconostoc-lactis_A0A5B8T6J5 Streptomyces-sp-1-11_A0A510TG57Streptomyces-sp-BK340_A0A559TP75Streptomyces-sp-BK561_A0A4R7AIF2 Streptomyces-sp-PsTaAH-137_A0A327WP23 Streptomyces-puniciscabiei_A0A542UH58Streptomyces-sp-32133_A0A1H4R9P1 Bacillus-sp-AFS001701_A0A2A8MK23Clostridiales-bacterium-43-6_A0A1M2Z8R2 Mycobacterium-triplex_A0A024JQV2Mycolicibacterium-hodleri_A0A502EBU2Kribbella-sp-NEAU-THZ-27_A0A4V5UWB2Streptomyces-sp-BK161_A0A4R7HTV1 Lactobacillus-collinoides_A0A166HPY4Leuconostoc-lactis_A0A5B8TGQ5Weissella-soli_A0A5B8SIW4 Mycolicibacterium-rhodesiae_A0A1X0IV49Mycolicibacterium-cosmeticum_W9B6U5Rhodococcus-jostii-strain-RHA1_Q0SC14Streptomyces-sp-BK205_A0A4V2TV69Paenibacillus-sp-OV219_A0A1H7Z9Y0Paenibacillus-baekrokdamisoli_A0A3G9IW40Leptolyngbya-frigida-ULC18_A0A2T1E0Y0 Weissella-soli_A0A288Q6Z1 Rhodococcus-sp-OK302_A0A235G218Actinomadura-sp-NEAU-Ht49_A0A3M2M7K2Humibacter-sp-BT305_A0A345K3X9Cnuibacter-physcomitrellae_A0A1X9LWB3Streptomyces-sp-ISID311_A0A5C6WHD6Streptomyces-brevispora_A0A561TU06Streptomyces-antibioticus_A0A124HNJ5Streptomyces-sp-San01_A0A437P5T0Streptomyces-sp-BK141_A0A4R7GKR2Streptomyces-lasaliensis_A0A4U5WN73Streptomyces-bungoensis_A0A101TCR0Streptomyces-cellostaticus_A0A117PYB2 Mycobacterium-aquaticum_A0A1X0B9H5Rhodococcus-fascians_A0A260TN33Mycobacterium-sp-IEC1808_A0A1X2DIP7Streptomyces-sp-MMG1121_A0A0N0SXJ5Streptomyces-sp-CdTB01_A0A0U3QFZ4Streptomyces-sp-Ag109_A0A3N4SFV5Streptomyces-bungoensis_A0A117RBY8Streptomyces-sp-CB01883_A0A1Q5KJP7 Paenibacillus-whitsoniae_A0A3S0ARM5 Lactobacillus-rapi_A0A512PLP7 Mycobacterium-ahvazicum_A0A2K4YHY2Streptomyces-sp-NRRL-F-5122_A0A0X3RPA3Streptomyces-sp-BK329_A0A4R3BQ54Streptomyces-sp-Ag109_A0A1H5HQ35 Paenibacillus-sp-OV219_A0A1H8C916Paenibacillus-pectinilyticus_A0A1C0ZVY1 Mycobacterium-lentiflavum_A0A0E3WDW8Streptomyces-turgidiscabies-Car8_L7F3I1Streptomyces-sp-WM6378_A0A0M8TEI1Streptomyces-misionensis_A0A5C6IXM1Streptomyces-sp-GGCR-6_A0A3Q9C990Streptomyces-sp-BK674_A0A4R3EGV7Streptomyces-gilvosporeus_A0A1V0TK59Paenibacillus-sp-BK736_A0A4R3D0Y4Paenibacillus-sp-BK736_A0A4V2TZQ6 Rhodococcus-wratislaviensis_A0A402CB71Microbacterium-sp-cl127_A0A1I6HE57Streptomyces-sp-SDr-06_A0A367HRJ8Streptomyces-sp-DconLS_A0A1C5F0A7Streptomyces-malaysiense_A0A1J4Q2I7Streptacidiphilus-pinicola_A0A2X0KBG1Streptomyces-puniciscabiei_A0A1D7Y5Q4Paenibacillus-sp-BK033_A0A4R1ZWH6 Rhodococcus-sp-1R11_A0A4Y8YRP9Rhodococcus-jostii-strain-RHA1_Q0RYM5Streptomyces-sp-MJM1172_A0A1Q5AUA8Streptomyces-sp-CB01373_A0A2M9IK93Actinomadura-sp-5-2_A0A2P4UE21Actinocorallia-herbida_A0A3N1D221Paenibacillus-sp-strain-JDR-2_C6D8G7 Mycobacterium-florentinum_A0A1X1U485Streptomyces-sp-MUSC-14_A0A1S2P1E3 Macrococcus-lamae_A0A4V3BEQ6 Rhodococcus-fascians_A0A260TDL7Mycobacterium-parmense_A0A1X2BCE5Streptomyces-kanamyceticus_A0A5J6GAK2 Nocardioides-dokdonensis-FR1436_A0A1A9GQ90 Mycolicibacterium-moriokaense_A0A370D3S1Mycolicibacterium-sp-P9-64_A0A5A7WHV0Mycobacterium-interjectum_A0A1X1WYH8Streptomyces-sp-CB02959_A0A2M9LGH9Streptomyces-griseofuscus_A0A3R8SD64 Mycolicibacterium-obuense_A0A0J6W365Streptomyces-griseochromogenes_A0A1B1B0F9Streptomyces-sp-IMTB-2501_A0A1R0L8W7Streptomyces-longwoodensis_A0A101R292 Frankia-symbiont-subsp-Datisca-glomerata_F8AV76 Mycolicibacterium-moriokaense_A0A318HGC1 Streptomyces-sp-SolWspMP-5a-2_A0A1C4RX06 Lactococcus-fujiensis-JCM-16395_A0A2A5RLS0 Mycolicibacterium-sp-P1-18_A0A5A7XMA2Mycolicibacterium-obuense_A0A4R5XD44Mycobacterium-sp-AB215_A0A2U3PDY9Streptomyces-sp-CB01201_A0A2M9J6M8Streptomyces-hundungensis_A0A387HMA3Streptomyces-sp-DSM-15324_A0A101UGH0 Paenibacillus-sp-18JY67-1_A0A3Q8X822 Microbacterium-hominis_A0A2K9DDK6Mycobacterium-sp-AB57_A0A2U3NSW6Streptomyces-mangrovisoli_A0A1J4NNT1Streptomyces-rubidus_A0A1H8EC26 Clostridium-grantii-DSM-8605_A0A1M5WX32 Streptomyces-griseochromogenes_A0A1B1B2Q7Streptomyces-yokosukanensis_A0A101P449 Aeromicrobium-sp-M2KJ-4_A0A371P3J7 Microbacterium-oxydans_A0A0F0L7D9Streptacidiphilus-jiangxiensis_A0A1H7TXW1Streptomyces-sp-WAC-06725_A0A429JKE4 Microbacterium-sp-13-71-7_A0A259S5K4Microbacterium-azadirachtae_A0A0F0LJV9Streptomyces-griseorubiginosus_A0A385ZSW1Streptomyces-incarnatus_A0A0G3AJG8 Aeromicrobium-sp-A1-2_A0A3B7DDD2 Streptomyces-diastatochromogenes_A0A233S0Z5 Lactococcus-sp-1JSPR-7_A0A387BD62 Mycolicibacterium-sp-P1-18_A0A5A7Y7K3Streptomyces-sp-8465_A0A4R7MDT3 Paraphotobacterium-marinum_A0A220VG37 --- Diatoms Microbacterium-pygmaeum_A0A1G8AMF2Mycobacterium-sp-ST-F2_A0A1Q4UHZ4Streptomyces-sp-PsTaAH-130_A0A327UTB1Streptomyces-sp-NRRL-B-3648_A0A0M8WVZ1 Lactococcus-sp-KACC-19320_A0A514Z9X3 Rhizoclosmatium-globosum_A0A1Y2CLM2Rhodococcus-sp-06-235-1A_A0A260BMV7Mycolicibacterium-fortuitum_A0A378V4N5Kitasatospora-sp-SolWspMP-SS2h_A0A327T6W3Streptomyces-paucisporeus_A0A1M7LS59 Paenibacillus-sp-MEC069_A0A4Y8QC51 Mycobacterium-chubuense-strain-NBB4_I4BIA4Mycobacterium-dioxanotrophicus_A0A1Y0C4P2Rhodococcus-sp-05-2256-B3_A0A260ID35Mycobacterium-sp-ST-F2_A0A1Q4UH37Rathayibacter-festucae-DSM-15932_A0A3Q9UZ51 Amycolatopsis-balhimycina-DSM-5908_A0A428WHS5 Lactobacillus-similis-DSM-23365-=-JCM-2765_A0A0R2FEB0Pediococcus-claussenii-strain-ATCC-BAA-344_G8PAE9 Mycolicibacterium-rhodesiae-strain-NBB3_G8RLQ1Rhodococcus-sp-06-469-3-2_A0A259YD25Rhodococcus-sp-15-649-2-2_A0A260R8H5Mycobacterium-sp-852002-50816_A0A1A1ZKX3Streptomyces-sp-MUSC-93_A0A1S2Q0T2 Actinokineospora-cianjurensis_A0A421BCD1 Chlamydomonas-reinhardtii_A8IQZ8Mycolicibacterium-chlorophenolicum_A0A0J6YJ67Streptomyces-diastatochromogenes_A0A233S148Macrococcus-epidermidis_A0A327ZR50 Candidatus-Aquiluna-sp-UB-MaderosW2red_A0A1G4W0U6Microbacterium-sp-T32_A0A163HEP1Microbacterium-lemovicicum_A0A3S9W6X1Streptomyces-yanglinensis_A0A1H6BA18Macrococcus-brunensis_A0A4R6BFI8 Microbacterium-enclense_A0A3S3M922Mycolicibacterium-llatzerense_A0A0D1JQM7 Mycolicibacterium-aubagnense_A0A5R8SV73 Anaerocolumna-jejuensis-DSM-15929_A0A1M7BDZ2 Aeromicrobium-sp-Root344_A0A0Q6VEV4 Microbacterium-sp-71-36_A0A2R9UAU2Microbacterium-sp-SCN-70-200_A0A1E4DEU5Microbacterium-kyungheense_A0A543F0M5Mycolicibacterium-peregrinum_A0A1A0RDX3Nocardioides-baekrokdamisoli_A0A3G9J0X1 Desulfosporosinus-orientis-strain-ATCC-19365_G7WDD5 Lactococcus-lactis-subsp-tructae_A0A2A5SQX4 Mycolicibacterium-conceptionense_A0A0J8UAF7Streptomyces-violaceusniger-strain-Tu-4113_G2P2G6 Aeromicrobium-ginsengisoli_A0A5M4FIL7 Lactococcus-lactis-subsp-cremoris-KW2_T2F2X0 Aeromicrobium-sp-Root236_A0A0Q8W2L8 Lactococcus-lactis-subsp-cremoris_A0A0M2ZUS7Lactobacillus-diolivorans-DSM-14421_A0A0R1S834 Rhodococcus-imtechensis-RKJ300-=-JCM-13270_I0WYC1 Firmicutes-bacterium-HGW-Firmicutes-9_A0A2N1ZYZ4 Lactococcus-lactis-subsp-cremoris-TIFN3_T0WTJ5 Mycolicibacterium-mucogenicum_A0A1A0N3L7 Rhodococcus-imtechensis-RKJ300-=-JCM-13270_I0WS47Mycolicibacterium-sp-NCC-Tsukiji_A0A391P7P8Nocardioides-sp-18JY15-6_A0A4R1CLY6

Streptomyces-roseochromogenus-subsp-oscitans-DS-12976_V6KUY6 Lactobacillus-collinoides-DSM-20515-=-JCM-1123_A0A0R2BEB7Lactobacillus-fabifermentans-T30PCM01_W6T9A2 Microbacterium-laevaniformans_A0A150HGR1 Clostridium-saccharoperbutylacetonicum-N1-4HMT_M1MCP9

Lactobacillus-odoratitofui-DSM-19909-=-JCM-15043_A0A0R1LZV8 Streptomyces-roseochromogenus-subsp-oscitans-DS-12976_V6K5C5 Lactococcus-lactis-subsp-cremoris-GE214_A0A084A7K1 Streptomyces-turgidiscabies-Car8_L7F300 Lachnoclostridium-phytofermentans-strain-ATCC-700394_A9KPU6 Lactococcus-lactis-subsp-cremoris-strain-MG1363_A2RHH2Lactobacillus-hilgardii-DSM-20176-=-ATCC-8290_C0XHD6 Microbacterium-laevaniformans_A0A4S2CWN4Streptomyces-collinus-strain-DSM-40733--Tu-365_S5VZL0 Lactobacillus-brevis-subsp-gravesensis-ATCC-27305_C2D343 Mycolicibacterium-aromaticivorans-JS19b1-=-JCM-16368_A0A064C9S6

Streptomyces-sp-Ag109_A0A1H5HPV5 Microbacterium-sp-oral-taxon-186-str-F0373_S3B703Streptomyces-roseochromogenus-subsp-oscitans-DS-12976_V6K5C0Streptomyces-rimosus-subsp-pseudoverticillatus_A0A0M9XS49 Aphanomyces-stellatus_A0A485KQ43Mycolicibacterium-aromaticivorans-JS19b1-=-JCM-16368_A0A064CRJ4 --- Pelagophytes

Streptomyces-sp-8445_A0A3N1L551 Weissella-oryzae-strain-DSM-25784--JCM-18191--SG25_A0A069CXY6 Scrippsiella-hangoei-SHTV5_CAMPEP-0191801128_Scrippsiella-hangoei-SHTV5 --- Dictyochophytes

Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199213708_Scrippsiella-hangoei-like-Strain-SHHI-4 Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199271914_Scrippsiella-hangoei-like-Strain-SHHI-4 Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199270842_Scrippsiella-hangoei-like-Strain-SHHI-4 Streptomyces-rapamycinicus-strain-ATCC-29253--DSM-41530--NRRL-5491--AYB-994_A0A0A0N3J0 Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199269076_Scrippsiella-hangoei-like-Strain-SHHI-4Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199266856_Scrippsiella-hangoei-like-Strain-SHHI-4Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199272418_Scrippsiella-hangoei-like-Strain-SHHI-4 Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199243852_Scrippsiella-hangoei-like-Strain-SHHI-4Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199306790_Scrippsiella-hangoei-like-Strain-SHHI-4 Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199248046_Scrippsiella-hangoei-like-Strain-SHHI-4 --- Chrysophytes

Streptomyces-avermitilis-strain-ATCC-31267--DSM-46492--JCM-5070--NBRC-14893--NCIMB-12804--NRRL-8165--MA-4680_Q82RL2 --- Cryptomonads (i) Scrippsiella and CCMP2436 --- Haptophytes CCMP2298-genomic_456111 --- Chlorophytes 60/-/- Chlamydomonas-reinhardtii_A8IQZ8 Candidatus-Aquiluna-sp-UB-MaderosW2red_A0A1G4W0U6 --- Dinoflagellates Aphanomyces-stellatus_A0A485KQ43 --- Other eukaryotes Frondihabitans-australicus_A0A495IE04 --- Bacteria Amnibacterium-kyonggiense_A0A4R7FPP3 Phytophthora-kernoviae_A0A421FP61 Arctic native sequence Phytophthora-ramorum_H3GAE5 Phytophthora-ramorum_H3GAY2 Antarctic native sequence Phytophthora-megakarya_A0A225WL75 Bipolar Arctic/ Antarctic (TARA) Phytophthora-sojae-strain-P6497_G4ZU16 CCMP2436-genomic_577981 Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199270842 Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199272418 -/23/15 Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199269076 Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199266856 Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199306790 Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199271914 Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199213708 Scrippsiella-hangoei-SHTV5_CAMPEP-0191801128 Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199243852 Scrippsiella-hangoei-like-Strain-SHHI-4_CAMPEP-0199248046 1039 0.3

1040 Fig. 5- Figure Supplement 3. Diversity and polar horizontal gene transfers of DUF347 domains. This 1041 figure summarises the consensus best-scoring tree topology obtained with RaxML under GTR, JTT 1042 and WAG substitution models for a 3942 branch x 240 aa alignment of all DUF347 domains (PF03988) 1043 sampled from UniRef, jgi algal genomes, MMETSP, Tara Oceans, and an independent transcriptome 1044 survey of Baffin Island Northwater communities. Branches are shaded by evolutionary origin and leaf 1045 nodes by biogeography (either: isolation location of cultured accessions where recorded; or on 1046 oceanic regions for which > 70% total abundance of each Tara meta-gene could be recorded). Thick 1047 branches indicate presence of a clade in all three best-scoring tree outputs. Top: overview of the 1048 global topology obtained; bottom: magnified topology of a two clades containing the Arctic 1049 freshwater dinoflagellate Scrippsiella and (i) Pavlovales sp. CCMP2436, or (ii) the Antarctic 1050 cryptomonad Geminigera. Support values for two nodes linking Scrippsiella, Geminigera and multiple 1051 Arctic-only TARA meta-genes are shown with labelled circles.

0.7 Prokaryotes-Bacteria-Firmicutes-_Clostridium-estertheticum-subsp-estertheticum_A0A1J0GMJ9

Deltaproteobacteria-bacterium-HGW-Deltaproteobacteria-18_A0A2N2I8B4

Prokaryotes-Bacteria-Firmicutes-_Clostridium-vincentii_A0A2T0BKX6Prokaryotes-Bacteria-Firmicutes-_Clostridium-estertheticum_A0A5N7IXX5

Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-baekrokdamisoli_A0A3G9JHD0

Prokaryotes-Bacteria-Firmicutes-_Clostridium-gasigenes_A0A1H0V9H3

Prokaryotes-Bacteria-Firmicutes-_Clostridium-beijerinckii_A0A2S2AYN5 Bacillus-thuringiensis-serovar-thuringiensis-str-IS5056_M1QU62

Bacillus-thuringiensis-serovar-israelensis-ATCC-35646_Q3EZF6Prokaryotes-Bacteria-Firmicutes-_Clostridium-tagluense_A0A401UJQ0

Ga0400921_01351221_447_782_1_2

Ga0392515_0012291_1_360_1_2

Ga0400920_02059051_161_373_1_2

Ga0400921_01351221_447_782_1

Halomonas-hydrothermalis_A0A291JWC0

Ga0400921_00421965_234_569_1_2 Bacillus-thuringiensis-serovar-zhaodongensis_A0A243LGP2 Alteromonadaceae-bacterium_A0A2D8J7Q6 Ga0392515_0012291_1_360_1

Ga0401205_02149580_1362_1694_1_2

Hydrocarboniclastica-marina_A0A4P7XKA1 Ga0400920_02059051_161_373_1 Bacillus-thuringiensis-serovar-sotto-str-T04001_C3DS66 Ga0401088_00728099_777_1109_1_2 Bacillus-thuringiensis-serovar-poloniensis_A0A243B2W7 Ga0400921_00421965_234_569_1

Bacillus-thuringiensis-serovar-toumanoffi_A0A2C9YTS7 Ga0400920_00611351_656_988_1_2 Bacillus-thuringiensis-serovar-novosibirsk_A0A242XZQ2Bacillus-thuringiensis-serovar-subtoxicus_A0A243DKP2 Ga0400921_00469042_644_976_1_2 Ga0401205_02149580_1362_1694_1

Bacillus-thuringiensis-subsp-kyushuensis_A0A2C9YVL2Guyparkeria-sp-SCN-R1_A0A426QQ31Ga0392515_0694664_712_1044_1_2 Ga0401205_02380034_3343_3678_1_2 Bacillus-thuringiensis-serovar-navarrensis_A0A243AAS5 Ga0401088_00728099_777_1109_1 Halomonas-sp-MES3-P3E_A0A2N1ATQ4 Ga0376351_1183075_277_609_1_2

Ga0400921_00586580_9967_10302_1

Ga0400920_00611351_656_988_1Ga0400921_00469042_644_976_1 Bacillus-thuringiensis-serovar-ostriniae_A0A243FNP9 Halomonas-anticariensis-strain-DSM-16096 Ga0392515_0694664_712_1044_1Halomonas-campaniensis_A0A246RY52Desulfobacteraceae-bacterium-4572_A0A1W9UDF5 Ga0392514_0263868_35_415_1_2

Ga0376351_1183075_277_609_1 Desulfomicrobium-norvegicum-strain-DSM-1741Halomonas-sp-141_A0A2M9TBX7

Halomonas-sp-KO116_A0A0D5M252

Ga0392514_0263868_35_415_1 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-barcinonensis_A0A2V4VQV0Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-taichungensis_A0A329QUR6Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-taichungensis_A0A2V3S425Bacillus-thuringiensis-serovar-kim_A0A243A634

Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-UASWS1643_A0A5M9UGB7 Methylomicrobium-alcaliphilum-strain-DSM-19304 Desulfomicrobium-apsheronum_A0A1I3WTK9 Tepidibacter-thalassicus-DSM-15285_A0A1M5S016 MATOUv2_138482561_2 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-FSL-R5-0765_A0A1R1FFN1Bacillus-thuringiensis-subsp-higo_A0A243K7Y7 Swingsia-sp-F3b2_A0A4Y6U799Komagataeibacter-medellinensis-strain-NBRC-3288 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-OK003_A0A1H7GUU3Bacillus-thuringiensis-serovar-navarrensis_A0A243AGQ4 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-xylanexedens_A0A1L5LHV3Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-amylolyticus_A0A1R1DW17Bacillus-thuringiensis-serovar-thuringiensis-str-IS5056_M1QY81 Bacillus-thuringiensis-Bt18247_A0A1C9C0N7 Komagataeibacter-intermedius-AF2_A0A0N1N4B2Komagataeibacter-xylinus_A0A2D3HDF8Gluconacetobacter-sp-SXCC-1_F3SFA8Komagataeibacter-rhaeticus_A0A181CAU9Komagataeibacter-rhaeticus-AF1_A0A070A357 Prokaryotes-Bacteria-Firmicutes-_Acetobacter-sp-KACC-21233_A0A5C1YLN1 Halomonas-sp.-54_A0A124F6C7 Prokaryotes-Bacteria-Firmicutes-_Acetobacteraceae-bacterium_A0A4V1D494 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-GM1FR_A0A2M9NGK3 Halomonas-heilongjiangensis_A0A2N7TTB2 Betaproteobacteria-bacterium-HGW-Betaproteobacteria-9_A0A2N2QC38Burkholderiales-bacterium-RIFCSPLOWO2_A0A1F4LHM7 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-276b_A0A1H4HFC9Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-A59_A0A0M9BLF5Prokaryotes-Bacteria-Firmicutes-_Psychrobacillus-lasiicapitis_A0A544SZU8Bacillus-thuringiensis-T01-328_A0A0F6J201 Komagataeibacter-diospyri_A0A4P5NSB0 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-BGI2013_A0A2N3JP00Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-Root52_A0A0Q7SAJ1 Halomonas-endophytica_A0A2N7U4I2 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-MYb63_A0A2S8X3M2 Halomonas-sp-HAL1_G4F407 Comamonadaceae-bacterium_A0A4V1TV71 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-amylolyticus_A0A1R1BVD8Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-amylolyticus_A0A100VQL0Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-PCH8_A0A2S8P7K4Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-FSL-R5-192_W4AU98Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-CF095_A0A1G6TNP3 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-LK1_A0A2G7LVC8Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-pabuli_A0A327PRI4 Methylobacillus-flagellatus-strain-KT Komagataeibacter-oboediens_A0A318QUT2Komagataeibacter-xylinus-NBRC-13693_A0A0D6Q9E5 Bacillus-thuringiensis-YBT-1518_V5MK82 Halomonas-sp-TQ8S_A0A368U2T5

Ga0400920_00770072_4460_4798_1_2 Rickettsiales-bacterium_A0A2E9XQ82 Komagataeibacter-xylinus-E25_W5Y8K5

Ga0400920_00770072_4460_4798_1 Bacillus-mycoides-strain-KBAB4_A9VN06 Methylococcaceae-bacterium_A0A351UZ77 Komagataeibacter-europaeus_A0A0M0EKV4Komagataeibacter-europaeus-NBRC-3261_A0A0D6PZP3Komagataeibacter-swingsii_A0A2V4RSG0Komagataeibacter-nataicola_A0A1U9RIM7 Ga0401205_00896716_1875_2168_1_2Ga0392515_1267165_1268_1594_1_2 MATOUv2_60941648_2MATOUv2_67960031_3 Ga0400921_02099704_1341_1634_1_2Ga0400920_01838090_2872_3162_1_2 Betaproteobacteria-bacterium-HGW-Betaproteobacteria-18_A0A2N2SW14 Bacillus-sp-VKPM-B-3276_A0A3S0ZUD3 Halomonas-nitroreducens_A0A3S0I782 Ga0401205_00896716_1875_2168_1Ga0401088_00689547_518_709_1_2Ga0400920_00017244_386_712_1_2 Bacillus-thuringiensis-serovar-malayensis_A0A242X8R6 Gluconobacter-wancherniae-NBRC-103581_A0A511B240Komagataeibacter-sucrofermentans_A0A318QLK6 Ga0392515_1267165_1268_1594_1Ga0400920_01838090_2872_3162_1 Burkholderiales-bacterium-RIFCSPHIGHO2_A0A1F4ES47 Bacillus-thuringiensis-subsp-konkukian_A0A243ID62Bacillus-thuringiensis-subsp-finitimus_A0A243GR58Bacillus-thuringiensis-serovar-poloniensis_A0A243AUL2Bacillus-thuringiensis-HD-771_J3U6Y7 Kangiella-spongicola_A0A318D2N3 Ga0400921_02099704_1341_1634_1Ga0400920_00017244_386_712_1 Bacillus-thuringiensis-serovar-malayensis_A0A242X6L1Bacillus-cereus-strain-G9842_B7IMW1 Ga0401088_00689547_518_709_1 Bacillus-thuringiensis-serovar-coreanensis_A0A193CUZ0Bacillus-thuringiensis-subsp-kyushuensis_A0A243EM03Bacillus-thuringiensis-serovar-cameroun_A0A242WYD6Bacillus-sp-AFS012607_A0A2H3QS91 Ga0400920_01233321_7_240_1_2 Kangiella-sediminilitoris_A0A1B3BC59 Prokaryotes-Bacteria-Firmicutes-_Acetobacteraceae-bacterium_A0A4P7W721Prokaryotes-Bacteria-Firmicutes-_Acetobacter-orleanensis_A0A4Y3TPD9 Comamonadaceae-bacterium_A0A349WC50 Bacillus-thuringiensis-serovar-subtoxicus_A0A243DJ60Bacillus-cereus-str-Schrouff_R8C410 Bacillus-cereus-BAG6X1-2_J8AYY3Bacillus-thuringiensis_A0A1B1LDS4 Halomonas-aestuarii_A0A1J0VD39 Ga0400920_01233321_7_240_1 Bacillus-pseudomycoides-DSM-12442_C3BQZ2Bacillus-cereus-BAG1X2-1_R8FAZ5Anaerosporomusa-subterranea_A0A154BLN5Gottschalkia-acidurici-strain-ATCC-7906 MATOUv2_14024656_5 Gluconobacter-oxydans_A0A149UB48 Bacillus-thuringiensis-subsp-jegathesan_A0A243LXI5Bacillus-cereus-BAG1X2-3_R8G9C9 Halomonas-saccharevitans_A0A1I7AKV4 Gluconobacter-roseus-NBRC-3990_A0A4Y3M9B3 Simplicispira-sp-NY-02_A0A398C3T5 Bacillus-cereus-BAG1X2-2_R8G5D0Bacillus-cereus-BAG1X1-1_R8E5H3 Prokaryotes-Bacteria-Firmicutes-_Acetobacter-orientalis_A0A252AYU6Prokaryotes-Bacteria-Firmicutes-_Acetobacter-orientalis_A0A252C8T0Gluconobacter-oxydans_A0A149S6M0Gluconobacter-oxydans_A0A149QR09Gluconobacter-oxydans-DSM-3504_A0A067Z265Prokaryotes-Bacteria-Firmicutes-_Acetobacter-persici_A0A1U9LGD1 Bacillus-thuringiensis_A0A0K0QJY3Bacillus-sp-AG1163_A0A4R7LQ62 Prokaryotes-Bacteria-Firmicutes-_Acetobacter-orientalis_A0A251ZYF0Prokaryotes-Bacteria-Firmicutes-_Acetobacter-orientalis-21F-2_A0A0D6NNA7Komagataeibacter-saccharivorans_A0A347WDT2Gluconobacter-oxydans_A0A4R4A2N0Gluconobacter-oxydans-strain-621H_Q5FTJ1Prokaryotes-Bacteria-Firmicutes-_Acetobacter-persici_A0A252AR55 Burkholderiales-bacterium-64-34_A0A1Q3S0R2 Bacillus-toyonensis_A0A2C4P363Bacillus-cereus-BAG1X1-2_J8QNE1Bacillus-sp-FJAT-26390_A0A1B8W0U4 Gluconobacter-albidus_A0A149TI80Gluconobacter-sphaericus-NBRC-12467_A0A4Y3QC97Gluconobacter-kanchanaburiensis-NBRC-103587_A0A511B9P7 Betaproteobacteria-bacterium-HGW-Betaproteobacteria-1_A0A2N2VHZ1 Bacillus-thuringiensis-serovar-iberica_A0A2C9ZCD2Bacillus-toyonensis_A0A2A2P0W7Bacillus-cereus-BAG2O-1_R8JYA1Bacillus-sp-AG102_A0A369CUW3 Prokaryotes-Bacteria-Firmicutes-_Acetobacter-malorum_A0A177G995Prokaryotes-Bacteria-Firmicutes-_Acetobacter-malorum_A0A149RDA7Prokaryotes-Bacteria-Firmicutes-_Acetobacter-malorum_A0A149RKY2 Bacillus-cereus-BAG1O-3_S3IQU7Bacillus-sp-MYb78_A0A2S8VWQ7 Prokaryotes-Bacteria-Firmicutes-_Acetobacter-cerevisiae_A0A149VF16Prokaryotes-Bacteria-Firmicutes-_Acetobacter-malorum_A0A149V3D5Prokaryotes-Bacteria-Firmicutes-_Acetobacter-malorum_A0A087PJQ9 Giesbergeria-anulus_A0A1H9S7P5 Bacillus-thuringiensis-serovar-londrina_A0A242YLC0Bacillus-cereus-HuA3-9_R8CQU4Bacillus-cereus-HuA2-4_J8CMQ7Bacillus-sp-MYb56_A0A2S9HVG3Bacillus-sp-OV752_A0A2T5UVV8Bacillus-mycoides_A0A1D3NJD9Bacillus-cereus-K-5975c_R8J0R7Bacillus-sp-ok061_A0A1H6CLD3Brevibacillus-laterosporus_A0A2S5HZJ5 Prokaryotes-Bacteria-Firmicutes-_Acetobacter-cerevisiae_A0A149Q4B4 Bacillus-sp-196mf_A0A2V4XVA6Bacillus-sp-AFS098217_A0A2A7H6Q0Bacillus-sp-AFS017274_A0A2A8TJL3 Gluconacetobacter-diazotrophicus-strain-ATCC-49037 Bacillus-thuringiensis-subsp-medellin_A0A243NLA3Bacillus-cereus-HuA2-9_R8CP00Bacillus-sp-OK077_A0A4R3SZ85Bacillus-cereus-HuB4-4_R8RE37Bacillus-cereus-TIAC219_R8XPI8Bacillus-sp-AFS019443_A0A2H3PZW1 Prokaryotes-Bacteria-Oligoflexia-_Bdellovibrionales-bacterium-CG10_A0A2M6X389 Bacillus-cereus-HuA2-1_J8Y5H0Bacillus-cereus-VD146_R8MGK1 Marinospirillum-celere_A0A1I1I189 Prokaryotes-Bacteria-Firmicutes-_Acetobacter-oeni_A0A511XLE2 Bacillus-thuringiensis-subsp-indiana_A0A0K0SAM9Bacillus-mycoides_A0A0B5SEH5 Bacillus-cereus-VD021_R8HKK2Bacillus-sp-ok634_A0A1I6BTY6Bacillus-cereus-HuB1-1_J9CJA7Bacillus-cereus-VD022_J7VLM2Bacillus-mycoides_A0A090ZJ36 Magnetospirillum-sp-64-120_A0A1M3LME3 Ga0400921_00236210_402_716_1_2Ga0400920_02564679_193_477_1_2 Bacillus-thuringiensis-serovar-yosoo_A0A243CJA0Bacillus-sp-MB366_A0A1Q9KTR2Bacillus-sp-DB-2_A0A366FZC3Bacillus-cereus-VD142_J7T9B2Bacillus-sp-YF23_A0A2A9HPB3Cohnella-sp-M2MS4P-1_A0A494XP73 Prokaryotes-Bacteria-Firmicutes-_Acetobacter-cibinongensis-4H-1_A0A0D6N4N3 Snodgrassella-alvi-SCGC-AB-598-O02_A0A080JWY5 Bacillus-thuringiensis-subsp-higo_A0A243KVW1Bacillus-sp.-SRB_A0A328M4Y7Bacillus-cereus-VD048_J8HL02Marinisporobacter-balticus_A0A4R2L6T8 Prokaryotes-Bacteria-Firmicutes-_Acetobacter-cibinongensis_A0A1Z5YXX3 Xanthomonadales-bacterium-GWF1_A0A1G3ZZ71Acidovorax-sp-SCN-65-108_A0A1E3YZN3Simplicispira-sp-125_A0A2U1CA15 Bacillus-sp-CDB3_A0A1V9VZ78Bacillus-sp.-SRB_A0A328L8U7 Domibacillus-aminovorans_A0A177KRU3 Ga0400920_02564679_193_477_1Simplicispira-suum_A0A2S0MZ24 Bacillus-thuringiensis-serovar-sinensis_A0A243MY76Bacillus-pseudomycoides_A0A2H3MM86Bacillus-cereus_A0A1Q9HZD4Bacillus-cereus_A0A150DM20 Komagataeibacter-maltaceti_A0A2S3VZJ4Ga0400921_09189229_42_239_1_2Ga0400921_09189229_42_239_1 Ga0400921_00236210_402_716_1Acidovorax-sp-Root217_A0A0Q8TD70 Bacillus-cereus_A0A150CFV9Bacillus-cereus_A0A221C4Q3Bacillus-cereus_A0A5P9Y9F0 Bacillus-bombysepticus-str-Wang_A0A023P7P5Bacillus-pseudomycoides_A0A2C3W263Bacillus-cereus_A0A2B9PB67Bacillus-sp-AK8_A0A5S4JZL0 Domibacillus-mangrovi_A0A1Q5P0F0 Alicycliphilus-denitrificans_A0A420KA59 Brevibacillus-laterosporus_A0A502HME7 Bacillus-thuringiensis-Bt18247_A0A1C9BZB9Bacillus-pseudomycoides_A0A2B7GC71Bacillus-pseudomycoides_A0A1S9X0M0Aneurinibacillus-migulanus_A0A0D1XR15 Arenimonas-malthae-CC-JY-1_A0A091B8N2Nocardioides-sp-SLBN-35_A0A542RZP7 Bacillus-thuringiensis-T01-328_A0A0F6J0H6Bacillus-sp.-L_A0A0D0RJQ6 Bacillus-sp-AFS096315_A0A2A7IGY0Bacillus-pseudomycoides_A0A2B6IEG9Bacillus-cereus_A0A2A8LMW8 Leminorella-grimontii-ATCC-33999--DSM-5078_A0A085HE49 Bacillus-sp-AFS017336_A0A2H3MRI1Bacillus-sp-AFS053548_A0A2B9B9W8Bacillus-sp.-L_A0A0D0RIL2 Bacillus-simplex_A0A1N6Q1R2 Prokaryotes-Bacteria-Firmicutes-_Staphylococcus-saprophyticus_A0A1D4G807 Comamonas-thiooxydans_A0A096E738 Bacillus-sp-AFS055030_A0A2B8U321Bacillus-sp-AFS023182_A0A2H3RCL8Bacillus-mycoides_C2Y137 Magnetospirillum-marisnigri_A0A178ML80 Gluconacetobacter-liquefaciens_A0A370G9Q1Comamonas-thiooxydans_A0A0E3B787Acidovorax-temperans_A0A0D7KAC9Acidovorax-delafieldii-2AN_C5TB21 Bacillus-sp-AFS041924_A0A2C0ZE18Bacillus-sp-166amftsu_A0A1H3L325Bacillus-sp-OK838_A0A239LT42 Desulfobacter-hydrogenophilus_A0A328FEJ6Asaia-bogorensis-NBRC-16594_A0A0N7KUT7Asaia-platycodi-SF21_A0A060QK55 Ga0400920_00856893_307_546_1Ga0400920_00856893_307_546_1_2 Bacillus-luti_A0A1K0A285Bacillus-loiseleuriae_A0A0K9GZY0Bacillus-sp-BA3_A0A2N0YBN8 Prokaryotes-Bacteria-Oligoflexia-_Bdellovibrionales-bacterium-CG10_A0A2M6X7F4 Acidocella-sp-MX-AZ02_K5YYY3Curvibacter-putative-symbiont-of-Hydra-magnipapillata_C9Y8F1Halothiobacillus-sp-LS2_A0A191ZGM3Comamonas-testosteroni_A0A5A7MF91 Bacillus-cereus-Rock3-44_C2WD33Bacillus-butanolivorans_A0A0M0EZA9 Comamonas-testosteroni_A0A1Y1J0V4 Bacillus-sp-OV186_A0A2T5SGM0 Bacillus-sp-Soil768D1_A0A0Q9VLN9 Bacillus-thuringiensis-YBT-1518_V5MF76Bacillus-sp-MYb209_A0A2S8UE76 Nosocomiicoccus-massiliensis_A0A2J6NHY7 Acidovorax-sp-FJL06_A0A3N7FVF3 Bacillus-thuringiensis-F14-1_A0A5E9IEV3Bacillus-cereus-BDRD-ST196_C2STX5Bacillus-simplex_A0A3R8MJH0 Komagataeibacter-sp-AV-382_A0A371Z1T0 Comamonas-sp-AG1104_A0A370F2I2Acidovorax-sp-106_A0A497V3Z2 Bacillus-pseudomycoides-DSM-12442_C3BJ94Bacillus-lentus_A0A2X4W3H6 Afipia-sp-Root123D2_A0A0Q6YZR2 Candidatus-Schmidhempelia-bombi-str-Bimp_A0A484GEE1Halothiobacillus-sp-24-54-40_A0A259BFK6Comamonas-testosteroni_A0A096F2L6 Pontibacillus-litoralis-JSM-072002_A0A0A5HSL5Carnobacterium-sp-CP1_A0A0U3P1H3Bacillus-sp-NFR08_A0A368WUF4 Bacillus-simplex_A0A127DES8 Ga0400920_02980550_2_238_1Ga0400920_02980550_2_238_1_2 Comamonadaceae-bacterium-CG12_A0A2H0J0P0 Bacillus-cereus-BAG6O-2_J9A3X0 Comamonas-sp-E6_A0A0M2DM19 Bacillus-sp-007AIA-02001_A0A4Y9U3U4Bacillus-thuringiensis_A0A0S3BYM5 Afipia-sp-1NLS2_D6VAU6 Acidovorax-kalamii_A0A235EL36 Bacillus-cereus-VDM006_R8Q4F2Bacillus-mycoides_A0A4V6N0F3 Elstera-cyanobacteriorum_A0A255XR09 Bacillus-cereus-VDM021_R8T3P9Cohnella-abietis_A0A3T1DED3 Caenispirillum-salinarum-AK4_K9GP34 Bacillus-litoralis_A0A179SXQ5 Prokaryotes-Bacteria-Firmicutes-_Acetobacter-tropicalis_A0A291PI43Prokaryotes-Bacteria-Firmicutes-_Acetobacter-senegalensis_A0A252EIA6Bdellovibrio-sp-qaytius_A0A3T0RPQ5 Acidovorax-sp-93_A0A495FHT5 Aneurinibacillus-soli_A0A0U4WF64Bacillus-sp-Leaf13_A0A0Q6HH59 Azospirillum-sp-L-25-5w-1_A0A431VE41Prokaryotes-Bacteria-Firmicutes-_Acetobacter-senegalensis_A0A149U6D9Prokaryotes-Bacteria-Firmicutes-_Acetobacter-tropicalis_A0A511FLA1 Gammaproteobacteria-bacterium-HGW-Gammaproteobacteria-1_A0A2N2AF54Burkholderiales-bacterium-RIFCSPLOWO2_A0A1F4KGL9Rhodoferax-ferrireducens-strain-ATCC-BAA-621Comamonadaceae-bacterium-CG17_A0A2M7FM79 Bacillus-mycoides_A0A1G4ESV7Bacillus-taeanensis_A0A366XTB3 Azospirillum-sp-RU38E_A0A239ABI9Prokaryotes-Bacteria-Firmicutes-_Acetobacter-tropicalis_A0A149TS65Prokaryotes-Bacteria-Firmicutes-_Acetobacter-tropicalis_A0A094YPM7Prokaryotes-Bacteria-Firmicutes-_Acetobacter-senegalensis_A0A0U5EW79 Acidovorax-sp-94_A0A495I5B1 Bacillus-mycoides_A0A076WBV9Bacillus-mycoides_A0A1D3MN85 Prokaryotes-Bacteria-Firmicutes-_Acetobacter-tropicalis_A0A252A934Prokaryotes-Bacteria-Firmicutes-_Acetobacter-tropicalis-NBRC-101654_F7VDQ7 Rhodocyclaceae-bacterium-SHINM1_A0A455RAJ8Comamonas-sp-Z1_A0A5S4T279 Bacillus-sp-AFS054943_A0A2B8V928Bacillus-cereus-VD136_R8NUB0 Prokaryotes-Bacteria-Firmicutes-_Acetobacter-aceti_A0A1U9KIQ0Komagataeibacter-cocois_A0A365YXB4Tardiphaga-sp-OV697_A0A2U0U499 Betaproteobacteria-bacterium-HGW-Betaproteobacteria-13_A0A2N2UQI6 Bacillus-cereus-strain-B4264_B7H6D3Bacillus-cereus_A0A2A7HWN8 Prokaryotes-Bacteria-Firmicutes-_Acetobacter-peroxydans_A0A4Y3TTP9Prokaryotes-Bacteria-Firmicutes-_Acetobacter-indonesiensis-5H-1_A0A0D6NB59 Bacillus-thuringiensis-MC28_K0FRF6Bacillus-cereus-BAG1X1-1_R8DX13Bacillus-cereus-BAG1X2-3_R8GFD6Bacillus-cereus-BAG1X2-1_R8FHK4Bacillus-paranthracis_A0A4P9F2I5Bacillus-thuringiensis_A0A243G3K8Bacillus-cereus-VD021_R8HDG5 Gluconobacter-cerinus_A0A1B6VMG2Prokaryotes-Bacteria-Firmicutes-_Acetobacter-indonesiensis_A0A252AXE4Prokaryotes-Bacteria-Firmicutes-_Staphylococcus-massiliensis-S46_K9AIU8 Bacillus-thuringiensis_A0A0K0QEV1Bacillus-cereus-BAG1X2-2_R8FY35Bacillus-cereus_A0A2B0M165Bacillus-cereus-VD118_R8QA08 Ga0401205_01880534_182_520_1_2Ga0401205_01880534_182_520_1 Comamonadaceae-bacterium-CG_A0A2M8E4V8 Bacillus-pseudomycoides_A0A2B5WMK7Bacillus-thuringiensis_A0A1Y0TQ70Bacillus-cereus-BAG2O-1_R8K5W3Bacillus-paramycoides_A0A1J9U640Bacillus-cereus-Rock3-29_C2VLA7 Komagataeibacter-pomaceti_A0A318QQI0 Bacillus-pseudomycoides_A0A2H3MGA5Bacillus-thuringiensis_A0A2B4G2Q0Bacillus-cereus-Rock1-15_C2UGH6Bacillus-sp-BD59S_A0A516QSX2Bacillus-cereus_A0A2B1IUQ9 Bartonella-doshiae_A0A380ZFR0Gluconobacter-frateurii-M-2_A0A0D6PPW5Gluconobacter-oxydans-H24_K7S8Z8Gluconobacter-sp.-DsW_A0A252BMX1Gluconobacter-japonicus_A0A149U894 Gammaproteobacteria-bacterium-HGW-Gammaproteobacteria-4_A0A2N1XG87 Bacillus-pseudomycoides_A0A2B5H7T1Bacillus-sp-DU-106_A0A4V1CVG6Bacillus-cereus_A0A2A8S2V6Bacillus-cereus_A0A2C2U6I2 Prokaryotes-Bacteria-Firmicutes-_Acetobacter-ascendens_A0A1D8QZQ6Gluconobacter-thailandicus_A0A149SPF6Gluconobacter-japonicus_A0A149SEP0Prokaryotes-Bacteria-Firmicutes-_Staphylococcus-gallinarum_A0A3A0VN77 Acidovorax-caeni_A0A1I7I953 Bacillus-pseudomycoides_A0A1Y3M943Bacillus-sp-5mfcol31_A0A1I4H981Bacillus-toyonensis_A0A2B6MMA6Bacillus-zeae_A0A398BGL0 Prokaryotes-Bacteria-Firmicutes-_Acetobacter-pasteurianus-NBRC-3188_A0A401WT17Prokaryotes-Bacteria-Firmicutes-_Acetobacter-pasteurianus-strain-NBRC-3283Prokaryotes-Bacteria-Firmicutes-_Acetobacter-pasteurianus-386B_S6D3C7Prokaryotes-Bacteria-Firmicutes-_Acetobacter-pasteurianus_A0A1A0DEQ7Prokaryotes-Bacteria-Firmicutes-_Acetobacter-pasteurianus-subsp-pasteurianus-LMG-1262--NBRC-106471_A0A401WK07Prokaryotes-Bacteria-Firmicutes-_Acetobacter-pasteurianus-NBRC-3278_A0A401X2S1Magnetospirillum-caucaseum_M2Z9C3Gluconobacter-thailandicus_A0A5C0A4N6Gluconobacter-thailandicus-NBRC-3255_M9MAE0Gluconobacter-japonicus_A0A149S256Gluconobacter-frateurii-NBRC-101659_A0A0K8N0N8Gluconobacter-frateurii-NBRC-103465_A0A0S6TGR5Bradyrhizobium-lablabi_A0A0R3N705 Methylophilales-bacterium-39-45-7_A0A259GRT7Burkholderiales-bacterium-PBB6_A0A257CCM3 Bacillus-pseudomycoides_A0A2B6Z7L5Bacillus-sp-17-SMS-01_A0A2G6QJ78Bacillus-sp-RZ2MS9_A0A1G1UQ65Bacillus-cereus-172560W_C2P1A1Bacillus-cereus-BAG4O-1_J7YPM0Bacillus-sp-112mf_A0A1H4GZB8Bacillus-tropicus_A0A5C5A967Bacillus-toyonensis_A0A2C3SBY2 Bartonella-tribocorum_A0A2M6US61Prokaryotes-Bacteria-Firmicutes-_Acetobacter-aceti-NBRC-14818_A0A0D6MXD7Bdellovibrio-bacteriovorus-W_W5X094Rhodomicrobium-udaipurense-JA643_A0A037UUG0 Alcaligenaceae-bacterium-SJ-26_A0A516WE10Comamonadaceae-bacterium_A0A5C9CV40 Bacillus-sp-AFS075960_A0A2B4NFX1Bacillus-sp-MB366_A0A1Q9KIV7Bacillus-sp-MYb78_A0A2S8VS02Bacillus-cereus_A0A0E1MDA0Bacillus-bacterium_A0A506QI97 Bdellovibrionaceae-bacterium_A0A2D6JGS4Prokaryotes-Bacteria-Firmicutes-_Acetobacter-pomorum_A0A346DUH8Prokaryotes-Bacteria-Firmicutes-_Acetobacter-pomorum-DM001_F1YQX4Prokaryotes-Bacteria-Firmicutes-_Acetobacter-sp.-DmW_A0A5M8ZM57Bradyrhizobium-sp-strain-ORS-278_A4YTL6Bradyrhizobium-sp-LMTR-3_A0A1B9YXI7 Mehylophilales-bacterium-35-46-6_A0A258LL53 Bacillus-sp-166amftsu_A0A1H3RVQ2Bacillus-sp-AFS023182_A0A2H3RAI2Bacillus-sp-AFS094611_A0A2A7EAZ6Bacillus-thuringiensis_A0A4R4B6H9Bacillus-cereus-Rock3-44_C2W9I1Bacillus-cereus-AH1134_B5ULG9Bacillus-cereus-m1550_C2RAS8Bacillus-cereus-VD131_R8L856 Magnetospirillum-magnetotacticum-MS-1_A0A0C2UWG2Bradyrhizobium-sp-STM-3843_H0TM72Prokaryotes-Bacteria-Firmicutes-_Staphylococcus-vitulinus_A0A2T4PVK6 Bacillus-toyonensis_A0A2C4ESE5Bacillus-sp-196mf_A0A2V4Y5K7Bacillus-cereus-VD184_R8TK22Bacillus-cereus-VD115_J8H846Bacillus-cereus-VD166_J8MCP8Bacillus-sp.-L1B_A0A0D0QKL5Bacillus-cereus_A0A2A9WCQ0Bacillus-cereus-VD107_J8J5D9 Phaeospirillum-molischianum-DSM-120_H8FSR5Bradyrhizobium-sp-DOA9_A0A0S6UVY1Prokaryotes-Bacteria-Firmicutes-_Staphylococcus-aureus-C0673_A0A033UI21Jeotgalicoccus-halophilus_A0A1G8XIT4Jeotgalicoccus-nanhaiensis_A0A4Y9HME1Jeotgalicoccus-halotolerans_A0A3E0B182Prokaryotes-Bacteria-Firmicutes-_Staphylococcus-felis_A0A2K3ZEN3Prokaryotes-Bacteria-Firmicutes-_Staphylococcus-felis_A0A3E0IMH4 Gammaproteobacteria-bacterium-RIFOXYD12_A0A1G0KVA1Pseudomonas-sp-C272019_A0A5J6Q9S4 Bacillus-wiedmannii_A0A1A9Q0M1Bacillus-wiedmannii_A0A2C3PK84Bacillus-cereus-Rock3-28_C2V538Bacillus-sp-CDB3_A0A1V9VWU5Bacillus-sp-bc15_A0A1M6YPV5 Ga0401205_02380034_3343_3678_1 Ga0400921_00586580_9967_10302_1_2 Azospirillum-sp-M2T2B2_A0A2U9S3M5Bradyrhizobium-sp-Leaf396_A0A0Q6AQZ6Bradyrhizobium-sp-MOS003_A0A2T2PZ12Prokaryotes-Bacteria-Firmicutes-_Staphylococcus-gallinarum_A0A0D0SUM4Prokaryotes-Bacteria-Firmicutes-_Staphylococcus-simulans_A0A2X3QDI6 Bacillus-sp-dmp10_A0A371UQM2Bacillus-cereus_A0A1D3QKW2Bacillus-sp.-L1B_A0A0D0PYP6Bacillus-cereus_A0A2B9AY54Bacillus-cereus_A0A2B0N1N7 Azospirillum-sp-TSH64_A0A2U1XUZ4Azospirillum-sp-B21_A0A5A9FR83Bradyrhizobium-sp-ORS-285_A0A1Y6KGU6Prokaryotes-Bacteria-Firmicutes-_Staphylococcus-sp-SDB-2975_A0A3G4QWZ1Prokaryotes-Bacteria-Firmicutes-_Staphylococcus-simulans_A0A133QI77Prokaryotes-Bacteria-Firmicutes-_Staphylococcus-simulans_A0A2T4QW66Prokaryotes-Bacteria-Firmicutes-_Staphylococcus-sp-HMSC070A03_A0A1S1F5R9Gordonia-hirsuta-DSM-44140--NBRC-16056_L7L7P7 Burkholderiales-bacterium-RIFCSPLOWO2_A0A1F4N7V1 Bacillus-sp-UMTAT18_A0A0F5RGC5Bacillus-cereus-VDM006_R8QQ91Bacillus-mycoides_A0A1D3ND45Bacillus-wiedmannii_C2PHT0Bacillus-cereus_A0A1S9YMX6Bacillus-cereus_A0A221BZI2Bacillus-cereus_A0A2C5RI73Bacillus-cereus_A0A2C0XC35Bacillus-sp-LK2_A0A0J6KZA6 Azospirillum-lipoferum-strain-4B_G7Z6Q9Bradyrhizobium-sp-strain-BTAi1Bradyrhizobiaceae-bacterium_A0A3S0ES96Prokaryotes-Bacteria-Firmicutes-_Staphylococcus-condimenti_A0A143PDN0Prokaryotes-Bacteria-Firmicutes-_Staphylococcus-carnosus-subsp-utilis_A0A380F2I4 Bacillus-sp-5mfcol31_A0A1I4P2H8Bacillus-cereus-VDM021_R8TRE9Bacillus-sp-OV752_A0A2T5UQK2Bacillus-sp-BI3_A0A2N3P216Bacillus-albus_A0A1J9TNX7 Magnetospirillum-gryphiswaldense_A4U5M9Magnetospirillum-gryphiswaldense-strain-DSM-6361Prokaryotes-Bacteria-Firmicutes-_Staphylococcus-carnosus-strain-TM300_B9DK01Prokaryotes-Bacteria-Firmicutes-_Staphylococcus-piscifermentans_A0A239TKJ9 Bacillus-mycoides_A0A1S8GAU7 Ga0401088_00394674_127_462_1Ga0401088_00394674_127_462_1_2Ga0392515_0767950_786_1121_1_2Ga0400920_02351358_1151_1486_1_2Ga0400921_01455543_89_424_1 Bacillus-wiedmannii_A0A2A7BIV9Bacillus-sp-OK077_A0A4R3S600Bacillus-cereus_A0A1Q9I4D0Bacillus-cereus_A0A2B0JRG8 Ga0392515_0767950_786_1121_1Ga0400920_02351358_1151_1486_1Ga0400921_01455543_89_424_1_2 Azospirillum-sp-TSO35-2_A0A2U1VJJ3Prokaryotes-Bacteria-Firmicutes-_Staphylococcus-condimenti_A0A4Q7CLT1 Polynucleobacter-sphagniphilus_A0A1R0HDU9Corticimicrobacter-populi_A0A2V1K7V6Rhodocyclaceae-bacterium_A0A524AZJ3 Bacillus-anthracis_A0A2B8HT45Bacillus-cereus-VD136_R8P7W3Bacillus-cereus_A0A0A3VP70Bacillus-cereus_A0A1J9XFJ3 Bdellovibrio-sp.-CG10_A0A2H0WDL8 Corynebacterium-deserti-GIMN1010_A0A0M4CFD3 Polynucleobacter-hirudinilacicola_A0A210RYQ0Hydromonas-duriensis_A0A4R6Y7M9Dokdonella-immobilis_A0A1I4XPG3 Bacillus-toyonensis_A0A2B5YD40Bacillus-sp-GeD10_N1LP21 Phaeospirillum-fulvum-MGU-K5_S9TRC0Prokaryotes-Bacteria-Firmicutes-_Staphylococcus-agnetis_A0A242VCJ9Prokaryotes-Bacteria-Firmicutes-_Staphylococcus-agnetis_A0A2T4MSV7Veillonella-sp-AS16_W3Y151 Leminorella-richardii_A0A2X4UWC7Ralstonia-sp-MD27_A0A0J9GLN5Methylotenera-sp-17-45-7_A0A259D7L9Methylotenera-sp-24-45-7_A0A258XLS2Curvibacter-sp.-GWA2_A0A1F8VAV2 Bacillus-sp-KbaL1_A0A229M1K3Bacillus-sp-HY001_A0A556CFZ1Bacillus-anthracis_A0A2A7D261Bacillus-cereus-strain-ZK Bdellovibrio-sp-SKB1291214_A0A254QCD4Rhodospirillales-bacterium_A0A522W7V3Prokaryotes-Bacteria-Firmicutes-_Staphylococcus-microti_A0A0D6XP92Prokaryotes-Bacteria-Firmicutes-_Staphylococcus-rostri_A0A2K3YM85 Ephemeroptericola-cinctiostellae_A0A345D979 Bacillus-cereus_A0A2B9BF26 Magnetospirillum-magneticum-strain-AMB-1Veillonella-parvula-ATCC-17745_D1YPD6Veillonella-seminalis-ACS-216-V-Col6b_K9D773 Ralstonia-sp-NFACC01_A0A1I5LD74Rhodocyclaceae-bacterium_A0A5C7K5D9 Bacillus-cereus_A0A2C2U4W5Bacillus-cereus_A0A0G8EYR4Bacillus-cereus_A0A1G4KY42 Bdellovibrio-bacteriovorus-str-Tiberius_K7ZBC6 Corynebacterium-xerosis_A0A2N6T0A4 Polynucleobacter-sp-35-46-11_A0A258LWH2Polynucleobacter-sp-24-46-87_A0A259DBY6 Azospirillum-brasilense_A0A4D8QT86Bdellovibrio-sp-NC01_A0A514WV55 Polynucleobacter-aenigmaticus_A0A254PRP7Polynucleobacter-sp-35-46-11_A0A258MVE2Rhodoferax-sp-TH121_A0A255ZD07 Bacillus-cereus_A0A0J7FW76 Legionella-parisiensis_A0A1E5JTN4uncultured-bacterium_K2D3L0Bdellovibrio-bacteriovorus_A0A150WVS5Ga0400921_01755570_1_243_1Ga0400921_01755570_1_243_1_2 Polynucleobacter-sp-35-46-207_A0A258QNL2Polynucleobacter-sp-39-45-136_A0A259PD15Polynucleobacter-sp-39-46-10_A0A259ISU9 Bdellovibrio-sp-ZAP7_A0A514XKD3Magnetospirillum-moscoviense_A0A178MKS7Bdellovibrio-sp-ArHS_A0A0B8WE29 Bdellovibrio-bacteriovorus-strain-ATCC-15356Bdellovibrio-bacteriovorus_A0A161PEE4 Methylobacillus-sp-MM3_A0A1A9NJJ5mine-drainage-metagenome_A0A1J5R9E6 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-borealis_A0A089LKZ7 Breznakia-blatticola_A0A4R7ZC75 Polynucleobacter-sp.-GWA2_A0A1G3CRZ0Limnobaculum-parvum_A0A2Y9TYQ9Curvibacter-sp-AEP1-3_A0A1Y0NCM6Curvibacter-sp.-PD_MW3_A0A2D0IFQ8 Bdellovibrio-bacteriovorus_A0A1Z3N6T4 Erysipelotrichaceae-bacterium-MTC7_A0A1C0BVQ7Haematobacter-missouriensis_A0A212AMM8 Allochromatium-vinosum-strain-ATCC-17899 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-FSL-R7-269_W4CFL5Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-FSL-R7-0337_A0A1R1GF79Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-FSL-R7-277_W4E8W0Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-IHB-B-3415_A0A0B2FGB1Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-FSL-R5-0912_A0A089K7G7 Aquaspirillum-sp-LM1_A0A1U9JKF0 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-FSL-R7-0333_A0A1R1G4X7 Jeotgalibaca-dankookensis_A0A1S6IP82 Novimethylophilus-kurashikiensis_A0A2R5F8U6Oryzomicrobium-terrae_A0A5C1EC77 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-FSL-H8-0259_A0A1R1CYJ7Legionella-tucsonensis_A0A0W0ZU20Legionella-anisa_A0A2Z3KXJ7Bdellovibrio-bacteriovorus_A0A150WSC0Macrococcus-hajekii_A0A4R6BIU0 Allochromatium-warmingii_A0A1H3ALF0Uliginosibacterium-sp-TH139_A0A2N4XTM3Pragia-sp-CF-458_A0A411WQN2Pragia-fontium_A0A0G3CUN2Lysobacter-daejeonensis-GH1-9_A0A0A0F204Sphaerotilus-hippei_A0A318H8I7Pusillimonas-sp-YR330_A0A4R1LS49Curvibacter-sp.-GWA2_A0A1F8W799 Ga0401205_00320350_346_687_1Ga0401205_00320350_346_687_1_2Ga0392515_0991347_109_384_1_2Ga0392514_0284049_3182_3457_1_2Ga0400921_02115178_112_387_1_2Ga0400920_00462257_2715_2990_1_2Ga0392514_0284049_3182_3457_1Ga0400920_00462257_2715_2990_1Ga0401088_00351251_474_749_1Ga0401088_00351251_474_749_1_2Ga0392515_0991347_109_384_1Ga0400921_02115178_112_387_1 Macrococcus-bovicus_A0A4R6C0G4 Iodobacter-sp-BJB302_A0A2G3JDZ5 Ga0401205_03006811_160_570_1Ga0401205_03006811_160_570_1_2 Aquicella-lusitana_A0A370G375Prokaryotes-Bacteria-Oligoflexia-_Bdellovibrionales-bacterium-RIFCSPHIGHO2_A0A1F3TP28 Polaromonas-naphthalenivorans-strain-CJ2_A1VU18 uncultured-bacterium_K2C8V8 Veillonella-criceti_A0A380NMD9Ga0401205_02161277_388_735_1_2Ga0401205_02161277_388_735_1 Hydrogenophilaceae-bacterium-CG1_A0A1J4Z7L7Formivibrio-citricus_A0A1I5D677 Ga0376351_0253452_1_354_1Ga0376351_0253452_1_354_1_2 Cellulomonas-sp-HLT2-17_A0A4Q5N2F8 Pigmentiphaga-aceris_A0A5C0AWN9Hydrogenophilales-bacterium-CG12_A0A2M7I7J1 Ga0401088_00263288_12554_12964_1_2Ga0401088_00263288_12554_12964_1Ga0376351_0855028_1536_1754_1Ga0376351_0855028_1536_1754_1_2 Micrococcus-lylae_A0A378P249Roseicitreum-antarcticum_A0A1H2YSZ0Streptomyces-showdoensis_A0A2P2GHZ4 beta-proteobacterium-CB_M1SM74Pandoraea-sp-LMG-31116_A0A5E4YJ48 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-FSL-R7-0273_A0A089K9Q5 Ga0401205_01543262_9_278_1Ga0401205_01543262_9_278_1_2Ga0401205_00480262_103_378_1Ga0401205_00480262_103_378_1_2 Macrococcus-canis_A0A1W7A9F9Macrococcus-caseolyticus-strain-JCSC5402_B9EA40Macrococcus-caseolyticus_A0A2N0VQS5 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-FSL-R7-0331_A0A089KNF6 Enteractinococcus-helveticum_A0A1B7LWM6 Ga0400921_00465989_237_572_1Ga0400921_00465989_237_572_1_2 Planococcus-versutus_A0A1B1RXS9 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-DMB5_A0A101XW18Paenisporosarcina-quisquiliarum_A0A1H8CQA5H30_A0A5B0CXM3Ferrimonas-marina_A0A1M5R2G5Macrococcus-canis_A0A4R6C5G5Planctomycetaceae-bacterium_A0A356AKK8Planctomycetes-bacterium-Pan54_A0A5C5XKE2Agromyces-sp-FW100M-8_A0A4P6FCC7Ga0376351_5031851_3_206_1Ga0376351_5030079_3_206_1Ga0376351_5030079_3_206_1_2Ga0376351_5031851_3_206_1_2Jeotgalibaca-sp-H21T32_A0A3S9H9H7 Denitromonas-halophilus_A0A558EMA4 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-typhae_A0A1G8XSJ7Aquitalea-sp-FJL05_A0A3N7CTQ2 Macrococcus-canis_A0A4P9CEM6 Ga0376351_0808178_3_242_1_2Ga0376351_0808178_3_242_1 Denitromonas-halophilus_A0A557QY39 Desulfuromonas-acetoxidans-strain-DSM-684 Prokaryotes-Bacteria-Firmicutes-_Psychrobacillus-psychrodurans_A0A1I4W5Q0Macrococcus-caseolyticus_A0A3B0F8C5Rubinisphaera-brasiliensis-strain-ATCC-49424 Methylomonas-koyamae_A0A291ILT8 Legionella-moravica_A0A378JQZ7Legionella-sp-km535_A0A433KDR5 Methylomonas-koyamae_A0A177NKI3 Macrococcus-caseolyticus-subsp-hominis_A0A5E8SKN1Streptomyces-rubrolavendulae_A0A1D8G7Z5Streptomyces-fradiae-ATCC-10745--DSM-40063_A0A1Y2NTC2 Burkholderia-glumae-strain-BGR1_C5AGD8 Ga0392514_0203320_2474_2809_1_2Ga0392514_0203320_2474_2809_1Ga0376351_0770335_48_383_1Ga0376351_0770335_48_383_1_2 Prokaryotes-Bacteria-Firmicutes-_Firmicutes-bacterium_A0A350WY22Paracoccus-aminophilus-JCM-7686_S5YB28 Thiorhodococcus-drewsii-AZ1_G2DXH4Chromatium-okenii_A0A2S7XTB3 Arenimonas-metalli-CF5-1_A0A091B1X9Methylophilales-bacterium-16-45-7_A0A258V2E9Methylophilales-bacterium-28-44-11_A0A258Q922Methylophilaceae-bacterium-17-44-8_A0A259CXW3 Rhodopirellula-sallentina-SM41_M5U6E2Planctomycetes-bacterium-Pla22_A0A5C5WL24Cohaesibacter-sp-H1304_A0A2N5XTI0Verrucomicrobia-bacterium-RIFCSPHIGHO2_A0A1G3ZMT4 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-oryzae_A0A1A5YR69 Oceaniovalibus-sp-ACAM-378_A0A5D0SA87 Aquimonas-voraii_A0A1G6U7L3 Ga0376351_1248005_4357_4650_1Ga0376351_1248005_4357_4650_1_2Halomonas-sp-YLB-10_A0A3N9UJU6Prokaryotes-Bacteria-Firmicutes-_Psychrobacillus-psychrotolerans_A0A1I5ZGL9Prokaryotes-Bacteria-Firmicutes-_Psychrobacillus-sp-OK028_A0A1H0BR58Cohaesibacter-marisflavi_A0A1I5IQ40 Methylomonas-sp-DH-1_A0A172UAM6 Tahibacter-aquaticus_A0A4R6Z891 Streptomyces-griseus_A0A380MJX4Streptomyces-sp-ADI98-12_A0A3N6J3N1Streptomyces-sp-MZ04_A0A4R9EP68Stackebrandtia-endophytica_A0A543AUD3 Aromatoleum-tolulyticum_A0A1N6W100 Ga0376351_2625156_3_230_1_2Ga0376351_2625156_3_230_1 Burkholderia-sp-MSHR3999_A0A0D0HAL2 Carnobacterium-divergens_A0A2R7ZRJ2Carnobacterium-divergens-DSM-20623_A0A0R2HW49 Cryobacterium-sp-TMB1-7_A0A5R1NC17Cryobacterium-sp-TMN-39-2_A0A5F0F345Cryobacterium-sp-TMB3-12_A0A5R1PJ82Streptomyces-sp-TSRI0384-2_A0A2M9HWI5 Burkholderia-sp-OK233_A0A2C8YRE7 Dokdonella-fugitiva_A0A4V2S376Thiothrix-lacustris_A0A1Y1QJJ2 Cryobacterium-sp-LW097_A0A5E8DAR2 Caballeronia-choica_A0A158JWI2Paraburkholderia-terrae-BS001_I5D0Y5Paludibacterium-purpuratum_A0A4R7B990 Planococcus-halotolerans_A0A365KRX8Prokaryotes-Bacteria-Firmicutes-_Psychrobacillus-insolitus_A0A2W7MMF0Caryophanon-tenue_A0A1C0YMV5Planctomycetes-bacterium-Pan14r_A0A5C5Y843Planctomycetes-bacterium-Poly59_A0A5C6F4H7Cryobacterium-zongtaii_A0A2S3ZIU7Cryobacterium-zongtaii_A0A2S3Z8H1Streptomyces-sp-YIM-121038_A0A5B7UK28 Thauera-sp-D20_A0A2T4IF90 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-riograndensis_A0A132TDK9Methylophilus-sp-TWE2_A0A0K0SXU7Caryophanon-latum_A0A1C0Z5G1Prokaryotes-Bacteria-Chlamydiae_Estrella-lausannensis_A0A0H5E7A2 Jeongeupia-sp-USM3_A0A1D9BC31 Bacillus-mesonae_A0A3T0I4M8Thiobacillus-sp-0-1251_A0A1Q4ENE9Thiobacillus-sp-SCN-63-374_A0A1E4L2J7 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-riograndensis-SBR5_A0A0E4CZT0 Streptomyces-netropsis_A0A445N4D5 Bacillus-sp-OK085_A0A4R2X9W2Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-graminis_A0A089ME73Halomonas-eurihalina_A0A5D9CGP2Thiothrix-caldifontis_A0A1H4G3R5 Oceanobacillus-bengalensis_A0A494Z4C7 Halomonas-elongata_A0A1B8P5J0Halomonas-elongata-strain-ATCC-33173 Streptomyces-sp-DSM-15324_A0A117RSV2 Burkholderiales-bacterium-RIFCSPLOWO2_A0A1F4JSE9Rhodocyclales-bacterium_A0A363SHT9Thiobaca-trueperi_A0A4R3MU10 Bacillus-sp-B-jedd_A0A098F5D5Simiduia-agarivorans-strain-DSM-21679Thiobacillus-sp-SCN-63-57_A0A1E4P1N3Turicibacter-sanguinis_A0A174VVE0Turicibacter-sp-H121_A0A0X1TKI8Streptomyces-sp-SAI-083_A0A3N4T4M3Streptomyces-stelliscabiei_A0A0L0JLG0Ga0400920_07075548_2_232_1Ga0400920_07075548_2_232_1_2CAMPEP_0196590152_Pyramimonas-amylifera Bacillus-endophyticus_A0A3N6CSW0 Aquabacterium-olei_A0A2U8FMB1 Paraburkholderia-sp-BL10I2N1_A0A4R6ERN8Polaromonas-sp-OV174_A0A1I1I441Azoarcus-communis_A0A2U8GSC1Azoarcus-communis_A0A2U8H0Z5 Methylotenera-mobilis-strain-JLW8Sulfuritalea-hydrogenivorans-sk43H_W0SE47 Streptomyces-gilvosporeus_A0A1V0U3V5Streptomyces-atratus_A0A2Z5JNW5Streptomyces-sp-AC1-42W_A0A384ITN3 Burkholderia-ubonensis_A0A118H8Z9 Isobaculum-melis_A0A1H9U866 Streptomyces-sp-NBRC-110611_A0A1B6AP79 Bacillus-circulans_A0A0J1INW1 Ga0392515_0857580_2_343_1_2Ga0392515_0857580_2_343_1Ga0401205_03016616_55_405_1_2Ga0401205_03016616_55_405_1Streptomyces-sp-IMTB-2501_A0A1R0M8U0Alkalibaculum-bacchi_A0A366ICH0 Limnohabitans-sp-TS-CS-82_A0A2S7JSJ8Burkholderia-glumae_A0A2J9HAI6Burkholderia-sp-Bp8963_A0A3N8KL91 Rhodococcus-qingshengii_A0A4R5ZZL3 Limnohabitans-sp-B9-3_A0A2M6V5R5Paraburkholderia-sartisoli_A0A1H4HGW0 Bacillus-notoginsengisoli_A0A417YTF4 Facklamia-tabacinasalis_A0A5R9E0D6Aerococcaceae-bacterium_A0A3D0CLN0Gammaproteobacteria-bacterium_A0A3M1WVM6 Burkholderia-sp-Bp9125_A0A3N8B838 Bacillus-sp-7884-1_A0A268KCZ1Bacillus-aquimaris_A0A5D4U4L5Methylotenera-sp-La3113_A0A4Y9VQS8 human-gut-metagenome_W1WN37Intestinibacter-bartlettii-DSM-16795_A0A1T4V1T5 Candidatus-Nitrotoga-sp-MKT_A0A3E1DAL0Paraburkholderia-caballeronis_A0A1H7NZR5Burkholderia-sp-Bp9126_A0A3N8BX53Azoarcus-sp-PHD_A0A558DA83 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-P3E_A0A1Q5XJ36 Limnohabitans-sp-JirII-31_A0A2M6VLU8Limnohabitans-sp-JirII-29_A0A315CCU9Burkholderia-sp-OK233_A0A2C8YQW5 Bacillus-sp-OK048_A0A1G9X8T8Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-P46E_A0A1Q5XZ52Methylophilaceae-bacterium-11_Y0KFB4Prokaryotes-Bacteria-Firmicutes-_Psychrobacillus-sp-PB01_A0A5J6SUK0Prokaryotes-Bacteria-Firmicutes-_Psychrobacillus-sp-FJAT-21963_A0A0Q3TYH2Micavibrio-aeruginosavorus-strain-ARL-13_G2KRZ3 Candidatus-Nitrotoga-sp-CP45_A0A3E1DV21Burkholderiaceae-bacterium-16_A0A0F0FU35Lysobacter-sp-ZS60_A0A3M8SP75Azoarcus-sp-DN11_A0A3S7U9Z7 Bacillus-sp-FJAT-22090_A0A0M5JE09Legionella-brunensis_A0A0W0SPK6Planctomycetes-bacterium-Pla52n_A0A5C6A531Rhodospirillaceae-bacterium_A0A3D2SS11Burkholderiales-bacterium-RIFCSPHIGHO2_A0A1F4G7E7Prokaryotes-Bacteria-Fusobacteria_Leptotrichia-wadei_A0A510KTN1 Burkholderia-cenocepacia-strain-AU-1054_A0A0H2XNM8Burkholderia-pseudomultivorans_A0A132F0F6Paraburkholderia-eburnea_A0A2S4M9T4Limnohabitans-sp-Jir61_A0A315C5N5 Bacillus-sp-YLB-04_A0A3D8GS94Bacillus-cohnii_A0A223KSA3 Micavibrio-aeruginosavorus-EPB_M4VI89Romboutsia-ilealis_A0A1V1I444Prokaryotes-Bacteria-Fusobacteria_Leptotrichia-hongkongensis_A0A510LB41Prokaryotes-Bacteria-Fusobacteria_Leptotrichia-trevisanii_A0A510JZI6Prokaryotes-Bacteria-Fusobacteria_Leptotrichia-sp-oral-taxon-879-str-F0557_U2PJ46Enterococcus-sp.-12C11_DIV0727_A0A242H216Enterococcus-sp.-7E2_DIV0204_A0A242AZK0Enterococcus-moraviensis-ATCC-BAA-383_R2T2R1Enterococcus-sp.-4G2_DIV0659_A0A242C6V0Enterococcus-sp.-9D6_DIV0238_A0A200J9Q6 Bacillus-endozanthoxylicus_A0A5J5HP58 Enterococcus-sp.-7D2_DIV0200_A0A242LDA0 Noviherbaspirillum-autotrophicum_A0A0C2BIJ8 Bacillus-sp-HNG_A0A371S484Thiothrix-lacustris_A0A1Y1QHT8Methylophaga-sp-SB9B_A0A4S5JLC5Herbinix-luporum_A0A0K8J5P8Prokaryotes-Bacteria-Fusobacteria_Leptotrichia-trevisanii_A0A510KYS7Enterococcus-ureasiticus_A0A1E5GDV1 Polaromonas-sp-35-63-35_A0A258NZT8 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-HGF7_F5LPT6 Burkholderia-ambifaria-strain-MC40-6_B1Z4N8Burkholderia-stagnalis_A0A3P0J6P2 Bacillus-sp-XXST-01_A0A3S0IKB6Rhodocyclaceae-bacterium_A0A3S0FBW2Methylophaga-lonarensis-MPL_M7PJ14Methylophaga-muralis_A0A1E3GSS2Desulfitobacterium-chlororespirans-DSM-11544_A0A1M7UAT1Enterococcus-ureilyticus_A0A1E5HGG8 Paraburkholderia-sp-BL18I3N2_A0A2T0KVQ8Noviherbaspirillum-sp-UKPF54_A0A5B8N4K1 Pradoshia-sp-D12_A0A5J6XMC0Bacillus-sp-FJAT-27986_A0A1B9B2D1Bacillus-sp-D12_A0A502BD19Bacillus-sp-AFS031507_A0A2C2UU28Limnohabitans-sp-2KL-1_A0A315DU29Ga0400920_03034389_305_640_1_2Ga0401088_00208539_3062_3397_1Ga0401088_00208539_3062_3397_1_2Ga0400920_03034389_305_640_1 Burkholderia-sp-FL-7-2-10-S1-D7_A0A103LHN2Paraburkholderia-sp-UYCP14C_A0A4Q6WN44 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-chitinolyticus_A0A410WPU0Romboutsia-lituseburensis-DSM-797_A0A1G9T192 Burkholderia-pseudomultivorans_A0A132EA56Paraburkholderia-monticola_A0A149PKM4Burkholderia-multivorans-CGD2_B9BNY4mine-drainage-metagenome_A0A3P3ZMS2Paraburkholderia-caffeinilytica_A0A346B907 Bacillus-timonensis_A0A4S3PML8Sporomusa-sphaeroides-DSM-2875_A0A1U7MBE1Bacillus-sp-AFS006103_A0A2A8ICA7Bacillus-sp-OV166_A0A1Y6EJL8Candidatus-Tokpelaia-hoelldoblerii_A0A1U9JTH9Prokaryotes-Bacteria-Firmicutes-_Clostridiales-bacterium_A0A2N6ALK1Neisseria-meningitidis-M0579_A0A0G4BXD8Neisseria-meningitidis_A0A425B1K7Enterococcus-sp.-9E7_DIV0242_A0A242KE78 Burkholderia-cenocepacia-strain-MC0-3_B1KAN5Paraburkholderia-strydomiana_A0A4R0X324 Bacillus-kyonggiensis_A0A4U1D6A5 Desulfitobacterium-dichloroeliminans-strain-LMG-P-21439Clostridioides-difficile-CD160_T3D4V9 Burkholderia-cenocepacia-strain-ATCC-BAA-245Burkholderia-sp-JKS000303_A0A2A9LB92Burkholderia-sp-USM-B20_A0A4R9M662Burkholderia-cenocepacia_A0A088U0X8 Prokaryotes-Bacteria-Firmicutes-_Pelosinus-propionicus-DSM-13327_A0A1I4IXY4Listeriaceae-bacterium-FSL-A5-0209_A0A099W8P7Listeria-sp.-SHR_A0A3N9TTG2Listeria-booriae_A0A099WEQ2Listeria-cornellensis-FSL-F6-0969_W7CFA2Listeria-riparia-FSL-S10-1204_W7CY24Desulfobulbaceae-bacterium-DB1_A0A1Q6DJB5Prokaryotes-Bacteria-Fusobacteria_Leptotrichia-sp-oral-taxon-212_A0A0K2JC87Hyphomonas-atlantica_A0A059E0F5Neisseria-meningitidis-alpha522_I4E2M3Neisseria-meningitidis_A0A425AHW0Neisseria-gonorrhoeae_Q50987Alysiella-filiformis-DSM-16848_A0A286E9M5Neisseria-polysaccharea-ATCC-43768_E2PH72 Burkholderia-sp-Bp8998_A0A3N8H4N7Burkholderia-sp-strain-CCGE1002_D5WFQ6 Bacillus-sp-LF1_A0A0U1NTZ8 Prokaryotes-Bacteria-Firmicutes-_Clostridium-saccharobutylicum-DSM-13864_U5MYP0Prokaryotes-Bacteria-Fusobacteria_Leptotrichia-sp-oral-taxon-215-str-W9775_U2RJ98Neisseria-meningitidis-serogroup-BVagococcus-penaei_A0A1Q2D8K3 Burkholderia-ambifaria-IOP40-10_B1FI68Burkholderia-pyrrocinia_A0A2Z5N978Burkholderia-sp-Bp9017_A0A3P0NL22Burkholderia-sp-Bp9142_A0A3N8A111Burkholderia-sp-Bp9131_A0A3N8AXQ6Burkholderia-sp-Bp9031_A0A3P0N7W8Burkholderia-sp-Bp9143_A0A3N8BRQ1Cupriavidus-basilensis-OR16_H1SCF3Cupriavidus-basilensis_A0A0C4YAA3 Alcanivorax-sp-EA2_A0A3D9IGX3Prokaryotes-Archaea-Euryarcheota_Methanosarcina-sp-Ant1_A0A1E7G7R1Listeria-weihenstephanensis-FSL-R9-0317_W7D6Y2Listeria-weihenstephanensis_A0A1S7FR04Desulfitobacterium-dehalogenans-strain-ATCC-51507Prokaryotes-Bacteria-Firmicutes-_Firmicutes-bacterium-HGW-Firmicutes-4_A0A2N2BVK6Neisseria-sp-HMSC061H08_A0A1S1CLT7Neisseria-meningitidis-serogroup-B-strain-MC58_Q9K1P4Neisseria-meningitidis-LNP21362_A0A0A8F5X4 Burkholderia-lata-strain-ATCC-17760_A0A3G3HLB7Burkholderia-sp-LA-2-3-30-S1-D2_A0A1B4F9I6Burkholderia-ambifaria-MEX-5_B1TCP7Burkholderia-sp-Bp8992_A0A3N8HRP7Paraburkholderia-terricola_A0A1M6VPX1 Bacillus-sp-1NLA3E_N0AVX2 Prokaryotes-Bacteria-Firmicutes-_Pelosinus-sp-UFO1_A0A075K645Prokaryotes-Bacteria-Firmicutes-_Clostridium-sulfidigenes_A0A084JHE6Prokaryotes-Bacteria-Firmicutes-_Clostridium-saccharobutylicum_A0A1S8NIN1Asaccharospora-irregularis-DSM-2635_A0A1M5LEH5Chitinimonas-sp-R3-44_A0A516SJX9Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-cellulosilyticus_A0A2V2YS29Prokaryotes-Bacteria-Firmicutes-_Acetobacterium-sp-KB-1_A0A2Z4IAH2 Burkholderia-cepacia-JBK9_A0A0U4D2X9Burkholderia-sp-IDO3_A0A2A4C8N4 Bacillus-azotoformans-LMG-9581_K6D3Z4 Bacillus-altitudinis_A0A5K1KRE8Bacillus-sp-nio-1130_A0A1C3YPP8Bacillus-sp-Y3_A0A5S4Y0R2Bacillus-sp-005A4HT-01001_A0A5R1Y0L8Bacillus-sp-ru95094_A0A1K2CGZ7Neisseria-elongata_A0A378TUZ1Listeria-grayi_A0A378MG74Serratia-sp-M24T3_I0QMA0 Burkholderia-sp-ABCPW-11_A0A124NUJ2Burkholderia-sp-Bp9012_A0A3N8DR61Paraburkholderia-tuberum_A0A1H1JYL3Undibacterium-pigrum_A0A318JBH1 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-IHBB-10380_A0A0D3VEQ1Desulfotomaculum-aeronauticum-DSM-10349_A0A1M6PDX1Oceanobacillus-profundus_A0A417Y9Z6Romboutsia-maritimum_A0A371ISN1Oceanobacillus-chungangensis_A0A3D8PKR7Bacillus-pumilus_A0A4V5TB14Prokaryotes-Bacteria-Firmicutes-_Clostridium-sartagoforme_A0A4S2DN16Prokaryotes-Bacteria-Firmicutes-_Clostridium-paraputrificum_A0A174D070Ga0392515_4781046_1_252_1Ga0392515_4781046_1_252_1_2Neisseria-sp.-GT4A_CT1_G3Z5N5Neisseria-macacae-ATCC-33926_F9EZ26 Pseudomonas-mesoacidophila_A0A2A4FE96_Pseudomonas-mesoacidophilaBurkholderia-lata-strain-ATCC-17760_Q39N59Burkholderia-sp-MSMB1835_A0A104C6Z8Burkholderia-sp-AU18528_A0A2G1S617Burkholderia-cenocepacia_A0A2N9CTD8Burkholderia-cenocepacia_A0A0M1IQU3Burkholderia-sp-HI2761_A0A228Q1M8Burkholderia-sp-Bp9004_A0A3P0SGG0Burkholderia-pyrrocinia_A0A0G3X1L3Burkholderia-ambifaria_A0A2S9KU04Burkholderia-stabilis_A0A1D7ZT90Burkholderia-latens_A0A1B4NYB8Ferrovum-sp-Z-31_A0A149VVQ3 Bacillus-azotoformans-MEV2011_A0A072NNQ9Marinobacter-mobilis_A0A1H2ZW86Prokaryotes-Bacteria-Firmicutes-_Clostridium-perfringens_A0A501UN41Prokaryotes-Bacteria-Firmicutes-_Clostridium-thermobutyricum-DSM-4928_A0A1V4SU98Prokaryotes-Bacteria-Firmicutes-_Clostridium-perfringens_A0A2X2Y4H3Prokaryotes-Bacteria-Firmicutes-_Clostridium-perfringens-strain-SM101Prokaryotes-Bacteria-Firmicutes-_Clostridium-thermobutyricum_N9XWX8Prokaryotes-Bacteria-Firmicutes-_Clostridium-perfringens_A0A4U9X9H3Prokaryotes-Bacteria-Firmicutes-_Clostridium-perfringens_A0A2X3EDC5Rubricoccus-marinus_A0A259U0N5MATOUv2_47433489_1Sphaerotilus-natans-subsp-sulfidivorans_A0A5C1Q1G5Listeria-grayi_A0A448Q4Y6Listeria-grayi-DSM-20601_D7UX32 Burkholderia-sp-AU16741_A0A228HF42Burkholderia-puraquae_A0A1X1PGF0Burkholderia-sp-MSh2_A0A084D831Burkholderia-territorii_A0A119QLT2Burkholderia-stabilis_A0A1Y1BWQ6Burkholderia-sp.-RF2_A0A102EPJ9Burkholderia-diffusa_A0A1B4C533 Bacillus-sp-S3_A0A513RD11 Marinobacter-halophilus_A0A2T1KD67Tumebacillus-flagellatus_A0A074LS20Brevibacillus-nitrificans_A0A3M8D6R5Prokaryotes-Bacteria-Firmicutes-_Acetobacterium-wieringae_A0A1F2PHS0Prokaryotes-Bacteria-Firmicutes-_Clostridium-cavendishii-DSM-21758_A0A1M6R934Prokaryotes-Bacteria-Firmicutes-_Acetobacterium-sp-MES1_A0A231NX15Prokaryotes-Bacteria-Firmicutes-_Clostridium-perfringens-D-str-JGS1721_B1V600Prokaryotes-Bacteria-Firmicutes-_Clostridium-perfringens-strain-ATCC-13124Prokaryotes-Bacteria-Firmicutes-_Clostridium-perfringens-strain-13Prokaryotes-Bacteria-Firmicutes-_Clostridium-perfringens_A0A133NCD3Prokaryotes-Bacteria-Firmicutes-_Clostridium-perfringens-B-str-ATCC-3626_B1R6A4Prokaryotes-Bacteria-Firmicutes-_Clostridium-perfringens-E-str-JGS1987_B1BXX2Vagococcus-entomophilus_A0A430AI26 Burkholderia-ambifaria-strain-ATCC-BAA-244Burkholderia-sp-AU15512_A0A228GCN6Burkholderia-contaminans_A0A1E3FZ87Burkholderia-metallica_A0A1B4HZB0Burkholderia-cepacia_A0A095GZC3Burkholderia-anthina_A0A103TBS9Burkholderia-cepacia_A0A0J5WX26Burkholderia-stabilis_A0A4V1PR13Burkholderia-sp-TJI49_F0FW03Burkholderia-sp-604_A0A561LT32 Peptoclostridium-acidaminophilum-DSM-3953_W8U9B6Pseudomonas-saudimassiliensis_A0A078MGJ7Marinobacter-sp-R17_A0A3N2QSI2Marinobacter-sp-T13-3_A0A139DDE7Marinobacter-persicus_A0A2S6G4I2Marinobacter-excellens-HL-55_A0A0N8KKD8Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-ferrarius_A0A1V4HFU0Prokaryotes-Bacteria-Firmicutes-_Clostridium-sp-IBUN13A_A0A0F4VWS0Prokaryotes-Bacteria-Firmicutes-_Clostridium-butyricum-E4-str-BoNT-E-BL5262_C4IMW1Prokaryotes-Bacteria-Firmicutes-_Clostridium-sp-IBUN125C_A0A0F4VWM8Prokaryotes-Bacteria-Firmicutes-_Clostridium-sp-HMSC19A10_A0A1F1KTL2Prokaryotes-Bacteria-Firmicutes-_Clostridium-cylindrosporum-DSM-605_A0A0J8D7E5Prokaryotes-Bacteria-Firmicutes-_Clostridiales-bacterium-GWB2_A0A1F8U4G7Prokaryotes-Bacteria-Firmicutes-_Clostridium-butyricum_A0A3R9D899Hyphomonas-sp.-BRH_c22_A0A0F2RCH0 Burkholderia-sp-Nafp24-1b_A0A495YDW6Burkholderia-sp-NFACC38-1_A0A1I0JXM4Burkholderia-contaminans_A0A2S5DNW3Burkholderia-sp-AU17325_A0A228HT05Burkholderia-sp-AU27893_A0A228JIA5Burkholderia-sp-AU6039_A0A228NY62Burkholderia-sp-HI2714_A0A228QDX1Burkholderia-sp-SRS-25_A0A4R4CA87Burkholderia-sp-LS-044_A0A4S5D362Burkholderia-cepacia_A0A095EJ83Burkholderia-sp.-28_A0A364GU41Burkholderia-anthina_A0A3P0CJS8 MATOUv2_16486448_1Marinobacter-nitratireducens_A0A072N224Marinobacter-sp-ZYF650_A0A5B0VD26MATOUv2_60971904_1Marinobacter-sp-T13-3_A0A139DHE0Marinobacter-sp-YJ-S3-2_A0A509MRZ1Cohnella-sp-G13_A0A559JGT0Prokaryotes-Bacteria-Firmicutes-_Clostridium-chromiireducens_A0A1V4ID85Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-18JY21-1_A0A4R4EGH8Prokaryotes-Bacteria-Firmicutes-_Clostridium-cadaveris_A0A1I2MDW2Prokaryotes-Bacteria-Firmicutes-_Clostridium-cadaveris_A0A316M5V9Prokaryotes-Bacteria-Firmicutes-_Clostridium-disporicum_A0A174I2B9Prokaryotes-Bacteria-Firmicutes-_Clostridium-botulinum-CD-str-DC5_A0A0A0ILZ0Prokaryotes-Bacteria-Firmicutes-_Clostridium-butyricum-DORA_W1UFP1Prokaryotes-Bacteria-Firmicutes-_Clostridium-butyricum_A0A0A6PSE0Prokaryotes-Bacteria-Firmicutes-_Clostridium-sp-IBUN22A_A0A0F4WR49Hyphomonas-jannaschiana-VP2_A0A059FAW7Hyphomonas-adhaerens-MHS-3_A0A069E2B7Hyphomonas-sp-CY54-11-8_A0A059DNH6Hyphomonas-adhaerens_A0A3B9GX32Hyphomonas-sp.-BRH_c29_A0A0F2QLD9Alkanindiges-illinoisensis_A0A4Y7XAI9Alkanindiges-sp-H1_A0A1S8CRD4 Burkholderia-sp-NFACC33-1_A0A1K1PQ88Burkholderia-cenocepacia_A0A071M826Burkholderia-vietnamiensis_A0A124PYD5Burkholderia-catarinensis_A0A1J9NJF1Burkholderia-cepacia_A0A107PP68Burkholderia-cepacia_A0A081V557 Marinobacter-pelagius_A0A366GZ83Marinobacter-lutaoensis_A0A1V2DQF1Oceanospirillales-bacterium_A0A2E5SAE7Prokaryotes-Bacteria-Firmicutes-_Clostridium-chauvoei-JF4335_S6ENY1Moraxellaceae-bacterium_A0A4Q5VP13Xanthomonadales-bacterium-RIFOXYA1_A0A1G4ALM1Listeria-floridensis-FSL-S10-1187_W7C805Pseudomonas-sp-TMW-21634_A0A494RD33Pseudomonas-fragi_A0A1H2JT07Pseudomonas-sp-OV144_A0A4R7TZM4Pseudomonas-lundensis_A0A266N5D9 Burkholderia-sp-JP2-270_A0A2U9T1M3Burkholderia-seminalis_A0A103K3U8Burkholderia-reimsis_A0A365QGP0 Prokaryotes-Bacteria-Firmicutes-_Clostridium-frigidicarnis_A0A1I0V7B7Fontibacillus-panacisegetis_A0A1G7L864Prokaryotes-Bacteria-Firmicutes-_Clostridium-baratii-str-Sullivan_A0A0A7FT14Prokaryotes-Bacteria-Firmicutes-_Clostridium-baratii_A0A0F3FT80Reinekea-blandensis-MED297_A4BH01Prokaryotes-Bacteria-Firmicutes-_Clostridium-uliginosum_A0A1I1JMC8Stenotrophomonas-acidaminiphila_A0A2W5LRN2Pseudoxanthomonas-sp-Root65_A0A0Q8FE86Pseudoxanthomonas-sp-CF385_A0A1H0ZZU2marine-sediment-metagenome_A0A0F9UFZ6Pseudomonas-reinekei_A0A1H0R9B0 Burkholderia-pyrrocinia_A0A087NL49Burkhslderia-vietnamiensis-strain-G4Burkholderia-cepacia_A0A2S8IQC7Burkholderia-sp-AU4i_U2FRB3 Bacillaceae-bacterium-SAOS-7_A0A271M1L9Bacillaceae-bacterium-SAS-127_A0A261QD63Pseudoxanthomonas-sp.-KAs_A0A2S6B1R3Pseudoxanthomonas-sp-3HH-4_A0A543E6I0Pseudoxanthomonas-sp-Root630_A0A0Q8EUD2Pseudomonas-sp-s199_A0A427EI03Pseudomonas-sp-TTU2014-066ASC_A0A0T6VE22Pseudomonas-sp-J237_A0A1E5XDZ7Pseudomonadaceae-bacterium_A0A2D5CAP7Pseudomonadaceae-bacterium_A0A2E8IFB4Pseudomonas-tolaasii-NCPPB-2192_A0A2N0E0I7Pseudomonas-arsenicoxydans_A0A502HNW9Pseudomonas-brassicacearum_A0A423I762Pseudomonas-sp-C9_A0A1V3MLC7Pseudomonas-sp-OV226_A0A2V2AAC8Pseudomonas-poae_A0A423F7G0Pseudomonas-sp-MYb60_A0A2S9AS21Pseudomonas-sp-R11-23-07_A0A3G8CQV0Pseudomonas-sp-LBUM920_A0A3G8DBA9Pseudomonas-kairouanensis_A0A4Z0ARD2Pseudomonas-azotoformans_A0A514BJJ9Pseudomonas-fluorescens_A0A1T2XY39Pseudomonas-sp-R4-34-07_A0A3G8CBM9Pseudomonas-sp-1-R-17_A0A1C3GNS2Pseudomonas-sp-R937_A0A2P8LCJ2Pseudomonas-marginalis_A0A5C5NJM0Pseudomonas-antarctica_A0A172Z7M3Pseudomonas-sp-IB20_A0A263NY51Pseudomonas-sp-R4-35-07_A0A3G8ALZ0Pseudomonas-sp-R4-39-08_A0A3G8B4Z8Pseudomonas-vancouverensis_A0A1H2PHM9Pseudomonas-sp-ok602_A0A1I4V267Pseudomonas-sp-RGB_A0A558FUR1Pseudomonas-mucidolens_A0A1H2LLP6Pseudomonas-sp-Z003-04C8344-21_A0A1H1QQ00Pseudomonas-frederiksbergensis_A0A1J0EMQ5Pseudomonas-sp-OV508_A0A2U0VQF6Pseudomonas-sp-S09G-359_A0A2K9CS68Pseudomonas-trivialis_A0A0R2ZMD5Pseudomonas-sp-K1S02-6_A0A418XLN2Rheinheimera-sp.-SA_A0A1B7UR07 Burkholderia-sp-KJ006_I2DYH7 Pseudomonadales-bacterium-RIFCSPHIGHO2_A0A1G3E8L7Pseudomonas-peli_A0A1G4TL68Pseudomonas-sp-HMWF010_A0A2R7SU56Pseudomonas-putida_A0A4R5SMQ0Pseudomonas-plecoglossicida-NB2011_S2K1Y8Microvirgula-sp-AG722_A0A329BEY0Pseudomonas-sp-H2_A0A099E5B9Pseudomonas-capeferrum_A0A084CCD5Pseudomonas-putida_A0A4D6XJN6Pseudomonas-putida_A0A379KJ22Pseudomonas-putida-strain-W619_B1JF15Pseudomonas-sp-p106_A0A427G491Pseudomonas-parafulva_A0A147GJ37Pseudomonas-putida-strain-GB-1_B0KMF2Pseudomonas-putida_A0A3M8S171Pseudomonas-reidholzensis_A0A383RZX9Pseudomonadales-bacterium-GWC1_A0A1G3CYC9Azotobacter-chroococcum-NCIMB-8003_A0A0C4WRV1Azotobacter-chroococcum_A0A4Q9VF42Azotobacter-chroococcum_A0A4Q9UV46Azotobacter-chroococcum_A0A4R1PT48Pseudomonas-sp-A252017_A0A1V3SLR8Pseudomonas-kilonensis_A0A1H5DVN9Pseudomonas-sp-NFACC24-1_A0A1I5IFC9Pseudomonas-sp-B12018_A0A2U1IIM5Pseudomonas-flexibilis_A0A0B3BP93Azotobacter-vinelandii-CA6_M9YI09Azotobacter-vinelandii-strain-DJPseudomonas-linyingensis_A0A1H7CBD6Pseudomonas-guangdongensis_A0A1H2IAK0Pseudomonas-sagittaria_A0A1I5W1N5Pseudomonas-sp-A-1_A0A4S4JGI0Pseudomonas-sp-TC-11_A0A2T5PF50 Burkholderia-sp-MSHR3999_A0A0D0H9K7Burkholderia-ubonensis_A0A1B4LJI8Burkholderia-ubonensis_A0A108CEV1Burkholderia-ubonensis_A0A104UHQ3Burkholderia-ubonensis_A0A119X331 Gammaproteobacteria-bacterium-HGW-Gammaproteobacteria-13_A0A2N1YQF2Pseudomonas-sp-PE08_A0A5J6QRD7Pseudomonas-sp-DY-1_A0A387AR16Pseudomonas-sp-JG-B_A0A5P1DUB7Pseudomonas-stutzeri_A0A0D7E5S8Pseudomonas-sp-R2A2_A0A2U9N733Pseudomonas-sp-TCU-HL1_A0A1B3EDD7MATOUv2_30522645_6Pseudomonas-benzenivorans_A0A1G8B713Pseudomonadales-bacterium-RIFCSPHIGHO2_A0A1G3DH88Pseudomonas-sp-HAR-UPW-AIA-41_A0A2A2IXI6Pseudomonas-resinovorans-NBRC-106553_S6BNW3Pseudomonas-stutzeri-TS44_I4JK17Pseudomonas-fluorescens_A0A5E7F9N5Pseudomonas-viridiflava_A0A1Y6JTB1Pseudomonas-syringae-pv-primulae_A0A0P9XL11Pseudomonas-syringae-pv-ribicola_A0A0N8SNV6Pseudomonas-viridiflava_A0A0Q0F8L9Pseudomonas-asturiensis_A0A1M7QHV2Pseudomonas-viridiflava_A0A2G0Z265Pseudomonas-zeshuii_A0A1M6GE34Pseudomonas-sp-HPB0071_N2JFN4Pseudomonas-sp-LTJR-52_A0A3G2N2R8Pseudomonas-luteola_A0A2X2EXS4Pseudomonas-cichorii_A0A3M4WGJ4Pseudomonas-cichorii_A0A3M4LVD8Pseudomonas-floridensis_A0A1X0N1U6 Burkholderia-sp-PAMC-26561_A0A125SMY3Caballeronia-mineralivorans-PML112_A0A0J1CU44Burkholderia-sp-Leaf177_A0A0Q5PB78Burkholderia-sp-SRS-46_A0A4R4CNL1Burkholderia-sp-Bp9126_A0A3N8C5R8Burkholderia-sp-Bp9125_A0A3N8E0B1Burkholderia-ubonensis_A0A104WLP0Burkholderia-ubonensis_A0A103RHF6Burkholderia-ubonensis_A0A102ZLA2Burkholderia-cepacia_A0A118KHT0Burkholderia-ubonensis_A0A104ILF9 Pseudomonas-sp-A46_A0A212B673Pseudomonas-furukawaii_L8MLG7Pseudomonas-sp-PIC25_A0A2A2E909Pseudomonas-avellanae_A0A2S3T6A8Pseudomonas-syringae-group-genomosp-3_A0A2S3TMP1Pseudomonas-avellanae_A0A261WJK6Pseudomonas-syringae-pv-apii_A0A0P9KH48Pseudomonas-syringae-pv-maculicola_A0A2V4P1Y4Pseudomonas-syringae-pv-tomato_A0A2R3F5Z1Pseudomonas-syringae-pv-theae_A0A0N8TIM6Pseudomonas-syringae-pv-tomato-strain-ATCC-BAA-871Pseudomonas-syringae-pv-spinaceae_A0A0Q0B073Pseudomonas-syringae-pv-antirrhini_A0A0P9L066Pseudomonas-syringae-pv-delphinii_A0A0P9PY22Pseudomonas-syringae-pv-persicae_A0A2K4TYZ6Pseudomonas-syringae-pv-actinidiae_A0A0K8LTZ1Pseudomonas-syringae-pv-apii_A0A3M3RH25Pseudomonas-syringae_A0A3M3BJ66Pseudomonas-syringae_A0A2S3URI0Pseudomonas-syringae-pv-maculicola_A0A0P9TIW0Pseudomonas-amygdali-pv-lachrymans-str-M302278_F3IRD1Pseudomonas-syringae-pv-viburni_A0A0Q0EQK1Pseudomonas-syringae-pv-avii_A0A2K4VZA9Pseudomonas-syringae-pv-coriandricola_A0A3M4TNS7Pseudomonas-syringae-pv-tagetis_A0A3M3Z4W9Pseudomonas-amygdali-pv-morsprunorum_A0A2S4I4M0Pseudomonas-syringae-group-genomosp-3_A0A2K4W8V0Pseudomonas-syringae-pv-berberidis_A0A0P9K424Pseudomonas-syringae-pv-primulae_A0A3M5TZW8Pseudomonas-syringae-pv-actinidiae_A0A2V0R4T6Pseudomonas-syringae-pv-maculicola_A0A0N0WBT6Pseudomonas-caricapapayae_A0A0P9PAV1Pseudomonas-syringae-pv-tagetis_A0A0Q0BZB0Pseudomonas-syringae-pv-helianthi_A0A0P9RSM3Pseudomonas-caricapapayae_A0A3M6EXL4Pseudomonas-syringae-pv-syringae-PD2766_A0A0W0ISC1Pseudomonas-syringae-pv-maculicola_A0A0N0W962Pseudomonas-viridiflava-ICMP-13104_A0A0W0H4T5Pseudomonas-syringae-pv-maculicola-str-ES4326_F3HT46Pseudomonas-sp-KUIN-1_A0A5H2XA96Pseudomonas-syringae-pv-syringae_A0A2V4PNP4Pseudomonas-syringae-pv-solidagae_A0A0P9Z8A0Pseudomonas-syringae-pv-aceris_A0A0P9LRK9Pseudomonas-cannabina_A0A3M3RHA0Pseudomonas-syringae-pv-alisalensis_A0A0P9HVI6Pseudomonas-syringae-pv-apii_A0A3M5WQI2Pseudomonas-syringae-pv-syringae-strain-B728a_Q4ZY51Pseudomonas-syringae-USA011_A0A5Q2PUX1Pseudomonas-sp-NP28-5_A0A2V3QAI1Pseudomonas-syringae-pv-helianthi_A0A3M4S3T7 Hydrogenophilales-bacterium-CG18_A0A2H0G553Betaproteobacteria-bacterium-CG2_A0A1J5CL37Caballeronia-sordidicola_A0A158GQV2Caballeronia-sordidicola_A0A4R1NVK6Burkholderia-pyrrocinia_A0A118Q732Burkholderia-stagnalis_A0A119WC51 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-B22019_A0A5B0WKK0Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-etheri_A0A0W1AS42Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-FSL-H7-0737_A0A089K0P0Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-odorifer_A0A1R0ZFW3Pseudomonas-panipatensis_A0A1G8M3C2Pseudomonas-sp-GV021_A0A2T5ZCE2Pseudomonas-graminis_A0A1C2DUX3Pseudomonas-nitroreducens_A0A239IDZ3Pseudomonas-punonensis_A0A1M7P3X9Pseudomonas-graminis_A0A1I0BN11Pseudomonas-sp-NZIPFR-PS5_A0A2G4E2D8Pseudomonas-lutea_A0A098T3A3Pseudomonas-sp-AU11447_A0A1B8VGC0Pseudomonas-sp-AU12215_A0A1B8TMY8Pseudomonas-sp.-LP_7_YM_A0A4R7WCG1Pseudomonas-sp-RIT-412_A0A329JFG4Pseudomonas-nitroreducens_A0A5R9AFQ2Pseudomonas-sp-21_A0A0F0DS92Pseudomonas-sp-Bc-h_A0A1V9URD6Pseudomonas-sp-NFACC02_A0A1H9TBM4Pseudomonas-sp-LAM1902_A0A5R9R262Pseudomonas-denitrificans_A0A5J6R706Pseudomonas-sp-T_A0A1V9UQY5Pseudomonas-sp-strain-ADP_Q937A1Alteromonadaceae-bacterium_A0A2A5HRS7 Burkholderia-sp-D7_A0A2C9BHW0 Bacillus-oceanisediminis_A0A562JL91Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-crassostreae_A0A162L7W2Prokaryotes-Bacteria-Firmicutes-_Clostridium-sp.-7_V9HD08Bacillus-megaterium_A0A5D4KPH6Marinospirillum-alkaliphilum-DSM-21637_A0A1K1Y398Marinobacter-nanhaiticus-D15-8W_N6VRH0Sporomusaceae-bacterium_A0A3C0UGZ4Bacillus-firmus_A0A380XAJ1Bacillus-firmus_A0A366JPD1Bacillus-oceanisediminis_A0A4R8GE77Paracoccus-sp-DMF_A0A4Y8P386Bacillus-sp.-2_A_57_CT2_E5WR77Bacillus-oceanisediminis-2691_A0A160M6L9Bacillus-oceanisediminis_A0A1S1YNS8 Caballeronia-udeis_A0A3M0URV6 Acinetobacter-sp-NBRC-100985_G7GFL8Acinetobacter-venetianus_A0A150HLU5Acinetobacter-tandoii_A0A515BHW9MATOUv2_67707557_4 Methylotenera-sp.-RIFCSPLOWO2_A0A1G1B362Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-GM2FR_A0A2M9MKY3Acinetobacter-sp-neg1_A0A0B0KMX7Acinetobacter-sp-BIGb0102_A0A3N4R657Acinetobacter-sp-NIPH-758_N8WAA2Acinetobacter-sp-CIP-102529_N8VZ74Acinetobacter-sp-CIP-102082_N8V514Acinetobacter-sp-CIP-102159_N8VP90Acinetobacter-sp-CIP-102143_N9S7N2Acinetobacter-parvus-DSM-16617--CIP-108168_N8RQZ2Acinetobacter-sp-CIP-102637_N8XI09 Grimontia-celer_A0A128F729Enterovibrio-nigricans-DSM-22720_A0A1T4UTP6Grimontia-indica_R1GPE0Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-3-5-3_A0A433XHM7Bacillus-sp-HMSC76G11_A0A1S1FPQ8Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-Soil766_A0A0Q9Q375Collimonas-fungivorans_A0A127PEA2Rheinheimera-salexigens_A0A1E7Q678hydrothermal-vent-metagenome_A0A1W1CLQ3Sulfurovum-sp-strain-NBC37-1_A6Q8Q3Arcobacter-sp-CAU-1517_A0A5R8XWQ8hydrothermal-vent-metagenome_A0A1W1CJF9 Grimontia-sp-AD028_A0A0F5ZWV3Enterovibrio-coralii_A0A135IDC7Enterovibrio-pacificus_A0A1C3EMM2Grimontia-marina_A0A128FDB2Enterovibrio-norvegicus-DSM-15893_A0A1I5K9N5Enterovibrio-norvegicus_A0A2N7L385Grimontia-hollisae-CIP-101886_D0I9Q8Grimontia-hollisae_A0A377J947Enterovibrio-norvegicus-FF-454_A0A1E5CAM5Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-elgii_A0A161S6H6Brevibacillus-sp-CF112_J2R2S5Brevibacillus-agri_A0A3M8BDS1Bacillus-wudalianchiensis_A0A1B9AMM4Brevibacillus-gelatini_A0A3M8B3D6Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-A3_A0A0N8PU49Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-aquistagni_A0A1X7KM10Bacillus-sp-FJAT-27231_A0A0K9H5Q8Methylomonas-methanica-strain-MC09_G0A491Thermomonas-fusca_A0A5R9PH86Pelomonas-saccharophila_A0A4R3VIH9Oxalobacteraceae-bacterium_A0A3D6AG21Paraburkholderia-sp-DHOA04_A0A3N6NLA9Massilia-sp-SOD_A0A430HRM5Collimonas-sp-OK307_A0A1I3EWP6Collimonas-sp-OK607_A0A1I0WPL0Massilia-violaceinigra_A0A2D2DNQ7Collimonas-sp-OK242_A0A1H3HDG5Duganella-sp-CF517_A0A1H8LRN6Herbaspirillum-sp-K2R10-39_A0A418X6W5Arcobacter-bivalviorum_A0A345IWZ9MATOUv2_68975183_4Arcobacter-pacificus_A0A5C2HD84Arcobacter-cloacae_A0A4Q0ZHU8Arcobacter-ebronensis_A0A4Q0Y855Arcobacter-cloacae_A0A4Q0V7I6Arcobacter-molluscorum-LMG-25693_A0A2G1DGX6Arcobacter-sp-CECT-8986_A0A4Q1AB50Arcobacter-ellisii_A0A347U8Y9Pseudoarcobacter-caeni_A0A363CWK4Sulfurovum-sp-AS07-7_A0A0C2Z686Arcobacter-sp-CECT-8987_A0A4Q0XQ15Haloarcobacter-mediterraneus_A0A4Q1AXJ6Sulfurovum-sp-enrichment-culture-clone-C5_A0A0S4XM79Sulfurovum-riftiae_A0A151CGE4 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-anaericanus_A0A433YBI5Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-glacialis_A0A168ELF2Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-macquariensis-subsp-defensor_A0A168JHX5Janthinobacterium-sp-HH01_L9P945Janthinobacterium-lividum_A0A1S1U833Janthinobacterium-sp-75_A0A4V3HCB3Janthinobacterium-sp-78_A0A2U0SWE5Janthinobacterium-sp-ROICE36_A0A2N6IMF4Janthinobacterium-svalbardensis_A0A290WV59Janthinobacterium-sp-SNU-WT3_A0A4Y6R822Massilia-psychrophila_A0A2G8T2T0Arcobacter-anaerophilus_A0A4Q0XUB7MATOUv2_57752456_4MATOUv2_79708849_6 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-antarcticus_A0A168Q464Bacillus-sp-FJAT-25496_A0A5B8Z083Enterovibrio-sp-CAIM-600_A0A4Q0YMG7Brevibacillus-parabrevis_A0A4Y3PM16Methylomonas-lenta_A0A177NG32Chitinimonas-taiwanensis-DSM-18899_A0A1K2HFH9Methylomonas-sp-Kb3_A0A2N0V7A5Halomonadaceae-bacterium_A0A2E2BNG3Burkholderia-dabaoshanensis_A0A2N7VXS7Trinickia-sp-7GSK02_A0A4U1I3Z6Paucimonas-lemoignei_A0A4V2UJ98Massilia-umbonata_A0A4P8HVQ1Massilia-eurypsychrophila_A0A2G8TI61Sulfurospirillum-sp-UBA12182_A0A2D3W1L1MATOUv2_10752096_4 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-macquariensis_A0A168AXY8Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-macquariensis_A0A1N6Z7J6Kushneria-konosiri_A0A2Z2H5D5Achromobacter-insolitus_A0A167C1U8Pandoraea-sp-LMG-31106_A0A5E4T8Z2Pandoraea-sp-64-18_A0A1Q4CFE9Pandoraea-sp-LMG-31014_A0A5E4WMG3Pandoraea-sp-LMG-31009_A0A5E4YRW2Pandoraea-sp-LMG-31009_A0A5E4ZAH4Pandoraea-norimbergensis_A0A0U2Y1J9Massilia-sp-Leaf139_A0A0Q5GX20Massilia-sp.-Mn16-1_A0A4S3FSU1Sapientia-aquatica_A0A4V3AUY5 mine-drainage-metagenome_A0A1J5RTI8Proteobacteria-bacterium-ST_bin11_A0A1W9JTE7Proteobacteria-bacterium_A0A2W4P319Ga0401205_01836080_106_447_1_2Ga0401205_01836080_106_447_1Ga0401088_02517151_272_457_1Ga0400920_02797718_4_189_1_2Ga0401088_02517151_272_457_1_2Ga0400920_02797718_4_189_1Ga0392514_0357978_615_956_1Ga0392514_0357978_615_956_1_2Ga0401088_02102747_2_292_1_2Ga0401088_02102747_2_292_1Paraburkholderia-tropica_A0A1A5XC39Pandoraea-sp-LMG-31013_A0A5E4SN06Pandoraea-sp-XY-2_A0A411JI29Pandoraea-sp-LMG-31114_A0A5E4WAF8Paraburkholderia-susongensis_A0A1X7J593Pandoraea-sp-LMG-31106_A0A5E4TSU1Pusillimonas-sp.-ANT_WB101_A0A5A9XAR0Massilia-sp-K1S02-61_A0A418Y8B9Massilia-timonae_A0A1S2N5I9Massilia-sp-CF038_A0A1M5LPD6 Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-selenitireducens_A0A1T2XH35Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-wynnii_A0A098MC79Tepidibacter-formicigenes-DSM-15518_A0A1M6QF92Comamonadaceae-bacterium_A0A4Q3NA62Ga0401088_02223065_21_362_1_2Ga0401088_02223065_21_362_1Ga0400921_01840244_216_422_1_2Ga0400921_01840244_216_422_1Ga0401088_00753990_3_329_1_2Ga0401088_00753990_3_329_1Ga0401205_01067411_40_381_1Ga0401205_01067411_40_381_1_2Ga0400921_01405096_502_843_1Ga0400921_01405096_502_843_1_2Cupriavidus-necator-strain-ATCC-43291Caballeronia-hypogeia_A0A157ZMY9Burkholderia-gladioli_A0A2S4NEG4Burkholderia-sp-SJZ115_A0A560VAW2Pandoraea-sp-ISTKB_A0A1E3LNA6Pandoraea-sp-LMG-20602_A0A5E4R7G8Pandoraea-fibrosis_A0A0B3SMV3Pandoraea-sp-LMG-31117_A0A5E5AV02Pandoraea-sp-LMG-31011_A0A5E4VWR5Pandoraea-fibrosis_A0A5E4XM16Massilia-sp-GEM5_A0A5C7FZM2Massilia-aurea_A0A422QIU7Xanthomonadaceae-bacterium_A0A4V2BKD6Oxalobacteraceae-bacterium_A0A4Q3INV5Massilia-oculi_A0A2S2DHK1Massilia-yuzhufengensis_A0A1I1UBT6Herbaspirillum-sp-SJZ107_A0A542LUA2Massilia-sp-MC02_A0A4Y9SLE5 Trichococcus-palustris_A0A143Y6F0Trichococcus-patagoniensis_A0A2T5IN39Bacillus-sp-AFS018417_A0A2A8SCP3Bacillus-sp-Y1_A0A385NKR6Bacillus-sp-FJAT-27916_A0A0K9GFS2Brevibacillus-fortis_A0A2P7VDG0Myxococcus-stipitatus-strain-DSM-14675Ga0400920_02435200_1_234_1Ga0400920_02435200_1_234_1_2Cupriavidus-metallidurans-strain-ATCC-43123Paraburkholderia-sp-7MH5_A0A4P7DB81Pandoraea-oxalativorans_A0A0E3YDY0Pandoraea-sp-LMG-31118_A0A5E5AG19Pandoraea-vervacti_A0A0C5K183 Ga0401088_00476519_62_271_1_2Ga0401205_00366650_42_251_1_2Ga0392515_5326665_16_225_1_2 Betaproteobacteria-bacterium-HGW-Betaproteobacteria-20_A0A2N2S5I2Thauera-sp-K11_A0A290ZJT2Rhodocyclales-bacterium-GT-UBC_A0A3L6M153Pradoshia-eiseniae_A0A2S7MWV5gamma-proteobacterium-IMCC1989_F3LE34Brevibacillus-brevis_A0A2Z4MQZ1Brevibacillus-sp-BC25_J2GGP3Brevibacillus-sp-AG162_A0A542QT02Brevibacillus-antibioticus_A0A4U2YBU8Pandoraea-faecigallinarum_A0A0H3WQ44 Ga0401205_00366650_42_251_1Ga0401088_00476519_62_271_1Ga0392515_5326665_16_225_1 Pseudogulbenkiania-subflava-DSM-22618_A0A1Y6BGA9Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-odorifer_A0A264EUY2Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-odorifer_A0A1R0Z463Brevibacillus-brevis-strain-47_C0Z9R3Bacillus-sp-FJAT-27238_A0A0K9MGE3Brevibacillus-brevis_A0A1Y4WWX1Lysinibacillus-sp-SDF0063_A0A544UM21Brevibacillus-brevis-X23_A0A291BTQ6Ga0400921_01477676_264_605_1_2Ga0400921_01477676_264_605_1Ga0401205_00299154_12346_12687_1Ga0401205_00299154_12346_12687_1_2Ga0401088_02506313_359_685_1_2Ga0401088_02506313_359_685_1Verrucomicrobiales-bacterium_A0A2E0QYZ3Caballeronia-arvi_A0A158F9H0Comamonas-testosteroni-strain-DSM-14576Comamonas-testosteroni-TK102_A0A076PWU7 Methylovulum-psychrotolerans_A0A1Z4C101Moraxellaceae-bacterium_A0A3D4UE03Marinobacter-sp-ELB17_A3JFU8Paenibacillaceae-bacterium_A0A4Q2M264Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-1011MAR3C5_A0A418SZ47Lysinibacillus-manganicus-DSM-26584_A0A0A3I5G7Oceanospirillaceae-bacterium_A0A3D2ATR7Brevibacillus-formosus_A0A220MMY3Brevibacillus-sp-NRRL-NRS-603_A0A2P7WSA9Brevibacillus-formosus_A0A4Y4HTV7Ga0376351_4426302_61_279_1Ga0376351_4426302_61_279_1_2Ga0376351_3002657_3_197_1Ga0376351_3002657_3_197_1_2MATOUv2_65691014_2 Methylotenera-versatilis-strain-301_D7DM89Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-durus-ATCC-35681_A0A0F7CKM4Betaproteobacteria-bacterium-HGW-Betaproteobacteria-7_A0A2N2QNN4 Betaproteobacteria-bacterium-HGW-Betaproteobacteria-12_A0A2N2VEX9Prokaryotes-Bacteria-Firmicutes-_Psychrobacillus-lasiicapitis_A0A544SU01Shewanella-sp-SNU-WT4_A0A4Y6IF47 Ga0400920_01076938_699_908_1_2Ga0400920_01076938_699_908_1 Gallionellales-bacterium-RIFCSPHIGHO2_A0A1G0EVP8Gammaproteobacteria-bacterium_A0A4Q5Q292 Oleiphilus-messinensis_A0A1Y0I8Y7Gallionellales-bacterium-RIFCSPLOWO2_A0A1G0D9W8bacterium_A0A533SLK0 Ga0401088_00823753_156_362_1_2Ga0401088_00823753_156_362_1Ga0392515_1008239_202_459_1Ga0392515_1008239_202_459_1_2Sedimentibacter-sp-SX930_A0A252CQ72Ga0401205_01830959_3402_3737_1_2Ga0392514_0395609_92_427_1_2Ga0376351_0495960_1351_1686_1_2Ga0392514_0395609_92_427_1Ga0400920_01329700_56_391_1_2Ga0400920_01329700_56_391_1Ga0376351_0495960_1351_1686_1Ga0401205_01830959_3402_3737_1Ga0401088_00075242_2_313_1_2Ga0401088_00075242_2_313_1Ga0400920_00355476_4080_4421_1_2Ga0400920_00355476_4080_4421_1Ga0400921_01020221_1041_1382_1Ga0400921_01020221_1041_1382_1_2 Aliidiomarina-iranensis_A0A432VTY9Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-Leaf72_A0A0Q4RHC8Thauera-propionica_A0A235EZE8Endozoicomonadaceae-bacterium-GTF-13_A0A3S3TZV1Endozoicomonas-sp-GTF13_A0A3P3VQW5 Ga0400920_00294340_640_975_1Ga0400920_00294340_640_975_1_2Ga0376351_1778015_1_240_1Ga0376351_1778015_1_240_1_2Bacillus-praedii_A0A4R1AXR4Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-BC26_A0A1I6WEM9Thauera-humireducens_A0A140IEG9 Ga0400920_00065171_438_632_1_2Ga0400921_00571371_532_726_1Ga0400920_00065171_438_632_1Ga0400921_00571371_532_726_1_2 Alphaproteobacteria-bacterium-ADurbBinA280_A0A1V5FY37Candidatus-Muproteobacteria-bacterium-RBG_A0A1F6T754Prokaryotes-Bacteria-Firmicutes-_Paenibacillus-sp-BIHB4019_A0A1B2DG56Thauera-aromatica-K172_A0A2R4BMM5Lysinibacillus-sp-FJAT-14222_A0A0M9WTP7 Hartmannibacter-diazotrophicus_A0A2C9D6C2Desulfuromonas-sp-DDH964_A0A143B8K6Bacillus-sp-FJAT-21945_A0A0M0X9P1Methylobacter-tundripaludum_A0A2S6H3B4Geomonas-terrae_A0A4S1CDJ7Geobacteraceae-bacterium-GWC2_A0A1G0M7D6Ga0401088_02387178_1357_1695_1Ga0400920_02331134_386_724_1_2Ga0400920_02331134_386_724_1Ga0376351_1080848_350_688_1Ga0401088_02387178_1357_1695_1_2Ga0376351_1080848_350_688_1_2Ga0392515_0577885_382_624_1Ga0392515_0577885_382_624_1_2 Idiomarina-insulisalsae_A0A432YDE2Bacillus-solani_A0A0Q3VHP2Thiohalobacter-thiocyanaticus_A0A426QKM1Thiohalobacter-thiocyanaticus_A0A1Z4VVM0Methylomonas-sp-LWB_A0A1S1Y3N8Methylomonas-koyamae_A0A177P0R2Lysinibacillus-sphaericus_A0A2S5D5Q0Lysinibacillus-odysseyi-34hs-1--NBRC-100172_A0A0A3IHD4Flavobacteriia-bacterium_A0A2G6F036Ga0401088_00726278_3366_3704_1_2Ga0392514_0429078_24437_24775_1_2Ga0400920_00529741_3844_4182_1Ga0376351_0444300_5084_5422_1Ga0401205_00921349_9768_10106_1Ga0401205_00921349_9768_10106_1_2Ga0392515_0355306_8240_8578_1_2Ga0376351_0444300_5084_5422_1_2Ga0401088_00726278_3366_3704_1Ga0392514_0429078_24437_24775_1Ga0400920_00529741_3844_4182_1_2Ga0392515_0355306_8240_8578_1 Methylococcales-bacterium_A0A418RFD2mine-drainage-metagenome_E6QSQ7Lysinibacillus-fusiformis-ZC1_D7WU60Ga0401088_02226718_1008_1292_1Ga0376351_0417124_38_322_1_2Ga0401205_00134241_1125_1409_1_2Ga0400921_00548264_1627_1911_1Ga0392515_0881167_2499_2783_1_2Ga0400920_02250766_905_1189_1Ga0401205_00134241_1125_1409_1Ga0376351_1148448_18_302_1Ga0376351_0417124_38_322_1Ga0392515_0881167_2499_2783_1Ga0392514_0481656_2000_2284_1Ga0400920_02250766_905_1189_1_2 Gammaproteobacteria-bacterium_A0A3M2BUB9Hydrogenophaga-crassostreae_A0A167HAL3Ga0400921_00548264_1627_1911_1_2Ga0401088_02226718_1008_1292_1_2Ga0392514_0481656_2000_2284_1_2Ga0376351_1148448_18_302_1_2Ga0392515_1117452_60_410_1_2Ga0400920_00655160_849_1199_1Ga0392515_1117452_60_410_1Ga0400920_00655160_849_1199_1_2Ga0400921_00230482_397_642_1_2Ga0400921_00230482_397_642_1 Martelella-mediterranea_A0A2T0JSK1Gammaproteobacteria-bacterium-28-57-27_A0A258S3D1Sporosarcina-sp-PTS2304_A0A345NZ38Sporosarcina-sp-P13_A0A2G5WM47 Ga0392514_0399891_37_306_1Ga0392514_0399891_37_306_1_2Ga0376351_0278772_1088_1273_1_2Ga0376351_0919389_44_280_1_2Ga0376351_0919389_44_280_1 Rhodopirellula-bahusiensis_A0A2G1W4E9bacterium_A0A2A4RD33 Ga0392514_0019934_4265_4558_1_2Ga0392514_0019934_4265_4558_1Ga0376351_0278772_1088_1273_1Ga0400921_01008220_6470_6763_1Ga0392515_0435236_4265_4558_1_2Ga0401088_02036361_3474_3767_1_2Ga0401088_02036361_3474_3767_1Ga0400921_01008220_6470_6763_1_2Ga0392515_0435236_4265_4558_1Ga0400920_00597445_3474_3767_1Ga0400920_00597445_3474_3767_1_2Ga0376351_0919337_110_337_1Ga0376351_0919337_110_337_1_2Ga0376351_1230677_36_281_1_2Ga0376351_1230677_36_281_1Ga0401205_00010327_6407_6700_1_2Ga0401205_00010327_6407_6700_1 Hirschia-baltica-strain-ATCC-49814Sporosarcina-sp-P29_A0A2G5ZFY2 Candidatus-Electrothrix-aarhusiensis_A0A3S3QNC8Sporosarcina-sp-P35_A0A2G6B344Methylococcaceae-bacterium-NSO1_A0A257NDQ6 MATOUv2_57834627_2 Flavobacteriales-bacterium_A0A3D6DDP4 Bacteroidetes-bacterium-ADurbBin397_A0A1V5P427

Mucilaginibacter-sp-44-25_A0A1Q3UFC9

Pasteurella-mairii_A0A379B5P3_Pasteurella-mairii Arcticibacter-pallidicorallinus_A0A2T0UCJ8 Actinobacillus-seminis_A0A263HD39 Pasteurella-dagmatis-ATCC-43325_C9PS16 Mucilaginibacter-sp-OV119_A0A318URF6 Ga0400920_01270947_1441_2016_1_2Ga0376351_0543811_3940_4515_1_2Ga0376351_0628543_2598_3173_1_2Ga0400920_01270947_1441_2016_1Ga0401088_00589358_161_532_1_2Ga0376351_0543811_3940_4515_1Ga0392514_0027058_520_723_1_2Ga0401205_01968127_4217_4792_1_2Ga0401205_01968127_4217_4792_1Ga0376351_0195491_929_1504_1_2 Ga0392515_0544279_1591_2166_1_2Ga0400921_01294514_425_796_1_2Ga0392515_0544279_1591_2166_1Ga0376351_0628543_2598_3173_1Ga0401088_00589358_161_532_1Ga0376351_0195491_929_1504_1 Gammaproteobacteria-bacterium-ESL0073_A0A2Z3HSB0 Ga0401205_00768132_372_947_1_2Ga0401205_00768132_372_947_1Ga0400921_01294514_425_796_1Ga0392514_0027058_520_723_1Ga0392514_0374648_1_561_1_2Ga0400920_02636937_184_759_1_2 Avibacterium-paragallinarum_A0A0F5EZL9Pseudomonas-sp-QZS01_A0A3S9XFM9 Ga0392514_0374648_1_561_1Ga0400920_02636937_184_759_1 Avibacterium-paragallinarum_A0A2V4F5M6 Avibacterium-paragallinarum_A0A3G8W7L1CAMPEP_0198197342_Pyramimonas-sp.Lysobacter-lycopersici_A0A516V605 Lysobacter-sp-UKS-15_A0A5D8Z3Z3 Ga0401205_03266948_27_494_1_2 Pelistega-indica_V8FZT1 Ga0376351_5096180_18_254_1_2Ga0401205_03266948_27_494_1Ga0376351_5096180_18_254_1 Helicobacter-cetorum-strain-ATCC-BAA-540 Ga0400920_00177152_175_396_1Ga0400920_00177152_175_396_1_2Ga0392515_0499094_44_391_1_2Ga0392515_0499094_44_391_1Ga0401205_00729803_274_486_1Ga0401205_00729803_274_486_1_2Ga0400921_00529854_779_1138_1Ga0400921_00529854_779_1138_1_2 Ga0400920_02772995_820_1380_1_2Ga0400920_02772995_820_1380_1Ga0400921_01715153_5_316_1_2 Avibacterium-volantium_A0A3S4GYN8 Bacteroidetes-bacterium-OLB12_A0A136LRU6Ga0400920_01375441_1586_1924_1_2Ga0400920_01375441_1586_1924_1Ga0392514_0406903_5_364_1Ga0392514_0406903_5_364_1_2Ga0400920_00706496_155_514_1_2Ga0400920_00706496_155_514_1 Ga0376351_3149142_1_291_1_2Ga0376351_3149705_1_291_1_2Ga0400921_01715153_5_316_1Ga0376351_3149142_1_291_1Ga0376351_3149705_1_291_1 MATOUv2_67821240_1 Haemophilus-pittmaniae_A0A377IZ89Mesocricetibacter-intestinalis_A0A4R6VFP8 MATOUv2_69560686_4 Helicobacter-cetorum-strain-ATCC-BAA-429 Ga0376351_0704748_1_294_1_2Ga0376351_0704748_1_294_1 Conservatibacter-flavescens_A0A2M8S0G6 Ga0401205_01516877_1029_1361_1Ga0392515_1115532_462_794_1Ga0392515_1115532_462_794_1_2Ga0400920_01022856_3539_3871_1Ga0400920_01022856_3539_3871_1_2Ga0401205_01516877_1029_1361_1_2 Ga0400921_00746341_1542_1799_1_2Ga0400921_00746341_1542_1799_1Ga0376351_1124877_268_846_1_2Ga0376351_1124877_268_846_1 Ga0401088_01751328_1300_1653_1_2Ga0401088_01751328_1300_1653_1Ga0376351_1449578_155_508_1Ga0376351_1449578_155_508_1_2Ga0401088_01106414_4962_5294_1_2Ga0392514_0167133_399_731_1Ga0392514_0167133_399_731_1_2Ga0401088_01106414_4962_5294_1Ga0376351_0202901_35_283_1_2Ga0376351_0202901_35_283_1Ga0376351_1324246_35_241_1_2Ga0376351_1324246_35_241_1Ga0376351_0215984_1_207_1_2Ga0376351_0215984_1_207_1 Ga0401205_02905660_195_752_1_2Ga0401088_05723402_22_222_1_2Ga0401088_02549211_140_514_1_2Ga0401205_02905660_195_752_1Ga0401088_08578309_2_202_1_2Ga0401205_01159478_118_492_1_2Ga0401088_05723402_22_222_1Ga0401088_02549211_140_514_1Ga0401088_08578309_2_202_1Ga0401205_01159478_118_492_1Ga0392514_0676561_43_375_1_2Ga0392514_0676561_43_375_1 Nicoletella-semolina_A0A4R2N5U1 Ga0401088_01395967_12089_12463_1_2Ga0400921_00225857_58_342_1_2Ga0376351_1009802_3145_3519_1_2Ga0400920_05319338_96_290_1_2Ga0400921_00225857_58_342_1Ga0376351_1009802_3145_3519_1Ga0400920_05319338_96_290_1 Achlya-hypogyna_A0A1V9Z863 Ga0400921_00220221_1_225_1Ga0400921_00220221_1_225_1_2 Ga0401088_01395967_12089_12463_1Ga0401205_01917975_497_871_1_2Ga0400920_01709749_413_787_1_2Ga0400920_01709749_413_787_1Ga0401205_01917975_497_871_1Ga0392515_1217574_16_348_1_2Ga0376351_1011785_214_792_1_2Ga0376351_1011785_214_792_1 Saprolegnia-parasitica-strain-CBS-22365_A0A067D4K2 Ga0401205_03145141_2_196_1_2Ga0392515_0248177_204_578_1_2Ga0400921_00924808_1_282_1_2Ga0401205_03145141_2_196_1Ga0400921_00924808_1_282_1Ga0376351_1056369_2275_2853_1_2Ga0401205_02526026_269_847_1_2Ga0392514_0794197_121_483_1_2Ga0376351_1056369_2275_2853_1Ga0401205_02526026_269_847_1Ga0392514_0794197_121_483_1Ga0392515_1217574_16_348_1 Ga0401088_01073013_273_536_1_2Ga0401088_01073013_273_536_1Ga0401088_00032882_269_502_1_2Ga0401088_00032882_269_502_1Ga0400920_02071202_1351_1695_1Ga0400920_02071202_1351_1695_1_2Ga0376351_4240893_1_213_1Ga0376351_4240893_1_213_1_2 Ga0401205_01833863_278_856_1_2Ga0401088_00011393_1241_1615_1Ga0401205_01833863_278_856_1Ga0392515_0248177_204_578_1 Helicobacter-pylori-SouthAfrica50_T2S802 MATOUv2_13843015_5 Ga0400920_00659648_4196_4774_1_2Ga0401088_00011393_1241_1615_1_2Ga0400920_00659648_4196_4774_1Ga0376351_1544744_41_619_1_2Ga0376351_1544744_41_619_1 Saprolegnia-diclina-strain-VS20_T0QAS2 MATOUv2_69791311_2 Ga0400921_01246432_167_745_1_2 MATOUv2_133912742_4MATOUv2_134603199_6MATOUv2_133722686_4 Ga0400920_02138628_3_281_1Ga0400920_02138628_3_281_1_2 Ga0401205_01976350_464_838_1_2Ga0400920_00631350_30_608_1_2Ga0400921_01246432_167_745_1Ga0401205_01976350_464_838_1Ga0400920_00631350_30_608_1 Helicobacter-pylori-PZ5024_T2T3F5Helicobacter-pylori-strain-SouthAfrica7_E8QS69 Ga0400920_03020391_614_814_1Ga0400920_03020391_614_814_1_2 Ga0401088_04788745_2_202_1_2Ga0401088_04788745_2_202_1Ga0401088_08576641_2_202_1 Helicobacter-pylori_A0A1Q2QPD7Helicobacter-pylori-SouthAfrica20_T1UB67Frederiksenia-canicola_A0A3N4WF75 MATOUv2_60935184_4 Ga0400920_02817810_151_492_1Ga0400920_02817810_151_492_1_2 Ga0401088_10805895_2_202_1_2Ga0401088_08576641_2_202_1_2Ga0401088_10805895_2_202_1 Helicobacter-pylori-GAM96Ai_M3RJ61Helicobacter-pylori-Hp-A-16_J0CM15Helicobacter-pylori-GAMchJs124i_M5YR84 Ga0400921_01044091_25_309_1_2Ga0400921_01044091_25_309_1 Helicobacter-pylori_A0A1Q2PJN0Helicobacter-pylori_A0A1A9HFL4Cricetibacter-osteomyelitidis_A0A4R2SX81 Ga0401205_03283678_331_672_1Ga0401205_03283678_331_672_1_2 Helicobacter-pylori_A0A496J4I3Helicobacter-pylori-Hp-H-5b_J0RSC5Helicobacter-pylori-GAM249T_M3NBU0Helicobacter-pylori-GAM103Bi_M3K2G9Helicobacter-pylori-Aklavik86_K7YP44Helicobacter-pylori_A0A4Y4XJG0Helicobacter-pylori_A0A2A6XW90 Ga0401088_00653510_594_935_1Ga0392515_1171234_5_346_1Ga0392515_1171234_5_346_1_2Ga0401088_00653510_594_935_1_2 Helicobacter-pylori-FD662_T5D0Z2Helicobacter-pylori-UM065_T0EYP4Helicobacter-pylori-FD703_T5D527Helicobacter-pylori_A0A1Q2RB43Helicobacter-pylori_A0A1Q2PSY9Helicobacter-pylori-98-10_B9XWP2Pasteurellaceae-bacterium-15-036681_A0A1V3TM53 Ga0376351_1421045_199_540_1_2Ga0376351_1421045_199_540_1Ga0400920_10866675_2_196_1Ga0400920_10866675_2_196_1_2 Helicobacter-pylori-Hp-H-18_J0DU71Helicobacter-pylori-GAM115Ai_M3MND1Helicobacter-pylori-GAM118Bi_M3N721Helicobacter-pylori_A0A2A6Z0Y8Helicobacter-pylori-Hp-P-1_J0PDJ9Helicobacter-pylori-HP250BFi_M3S1R2Helicobacter-pylori-Hp-H-36_J0L9E2Helicobacter-pylori-PZ5056_T2T5Y0Helicobacter-pylori-GAM245Ai_M3LLY6Helicobacter-pylori-GAM263BFi_M3PL89Helicobacter-pylori-GAM80Ai_M3RN22Helicobacter-pylori-HP260Bi_M3TPR1Helicobacter-pylori-GAM121Aii_M3LCB9Helicobacter-pylori-GAM201Ai_M3MYW6Helicobacter-pylori-Hp-H-1_M7S3I5Helicobacter-pylori-GAM114Ai_M3LIT4Helicobacter-pylori_A0A1V3AK29Helicobacter-pylori-GAM265BSii_M3RFB4Helicobacter-pylori-Hp-P-26_J0TMG9Helicobacter-pylori-Hp-P-1b_J0RBX1Helicobacter-pylori-Hp-A-5_I9R8Z2Helicobacter-pylori-GAM105Ai_M3MCS9Helicobacter-pylori-GAM254Ai_M3MUR3 Helicobacter-pylori_A0A1Q4MZ59Helicobacter-pylori_A0A2T6QUC5Helicobacter-pylori_A0A221JBD3Actinobacillus-ureae-ATCC-25976_E8KEY8Actinobacillus-equuli-subsp-equuli_A0A0A7MI59 Ga0400920_02277599_213_554_1_2Ga0400920_02277599_213_554_1Ga0392514_0337359_2_322_1_2Ga0392514_0337359_2_322_1 Helicobacter-pylori-Hp-H-29_I9SLF4Helicobacter-pylori_A0A0J8H0P2Helicobacter-pylori_A0A1Q2QJV5Helicobacter-pylori_A0A439AGK0 Ga0376351_1329509_507_728_1Ga0376351_1329509_507_728_1_2 Helicobacter-pylori_A0A293S665Helicobacter-pylori_A0A1V3BKQ0Helicobacter-pylori_A0A2A6YCM5Helicobacter-pylori-UMB_G1_M7RTR6Helicobacter-pylori-Hp-H-44_J0LSS0Helicobacter-pylori-GAM120Ai_M3MMN7Helicobacter-pylori-GAM93Bi_M3PF12Helicobacter-pylori-Hp-H-6_I9UP72Helicobacter-pylori_A0A5M8VVR8Helicobacter-pylori_A0A496HCK1Actinobacillus-suis-H91-0380_K0G037 Ga0401088_01887182_81_422_1_2Ga0376351_1341913_89_430_1Ga0376351_1341913_89_430_1_2Ga0401088_01887182_81_422_1Ga0392515_0302933_53_394_1_2Ga0392515_0302933_53_394_1 Helicobacter-pylori_A0A1V3ANX3Helicobacter-pylori_A0A438ZV79Helicobacter-pylori-strain-Gambia9424_s8QHW9Helicobacter-pylori_A0A2A6XCV0Helicobacter-pylori-oki112_X2HU65 Ga0400920_00457993_2_253_1Ga0400920_00457993_2_253_1_2Ga0392515_0515214_700_1041_1Ga0401205_01548307_787_1128_1_2Ga0401205_01548307_787_1128_1Ga0392515_0515214_700_1041_1_2Ga0392514_0116353_1_300_1_2Ga0392514_0116353_1_300_1 Helicobacter-pylori-FD577_T5D2S8Helicobacter-pylori-strain-PeCan4_E1Q2K5Helicobacter-pylori-Puno135_G2MA16 Ga0400920_00404854_127_408_1_2Ga0400920_00404854_127_408_1 Helicobacter-pylori_A0A2T6UH56Helicobacter-pylori-NQ4200_I9Q9E9 Helicobacter-pylori-Puno120_G2M4W4 Ga0392515_1223952_275_607_1_2Ga0392515_1223952_275_607_1Ga0400920_00994861_12_596_1 MATOUv2_138718091_5 Aggregatibacter-segnis_A0A369Y3Z1 Ga0400921_01611992_1_264_1_2Ga0400921_01611992_1_264_1Ga0400920_01662978_332_544_1_2Ga0400920_01662978_332_544_1 Ga0400920_00994861_12_596_1_2 Helicobacter-pylori-Aklavik117_K7Z596Aggregatibacter-segnis-ATCC-33393_E6KXG8 Ga0400921_01190692_1338_1679_1_2Ga0400921_01190692_1338_1679_1 Ga0401205_00184093_146_601_1_2Ga0400921_00264661_516_1022_1_2Ga0401205_00184093_146_601_1Ga0376351_1018431_452_733_1_2Ga0400920_00548446_701_1285_1Ga0400921_00264661_516_1022_1Ga0376351_1018431_452_733_1Ga0401205_00867616_42_323_1MATOUv2_97342531_4 Ga0400920_00401412_128_424_1_2Ga0400920_00401412_128_424_1Ga0392515_0264684_98_439_1_2Ga0392515_0264684_98_439_1Ga0400921_02076149_336_560_1_2Ga0400921_02076149_336_560_1Ga0400920_00696989_127_468_1_2Ga0400920_00696989_127_468_1Ga0401088_01062106_1686_2030_1_2Ga0401088_01062106_1686_2030_1 Ga0400920_00548446_701_1285_1_2Ga0401088_02447423_684_1268_1Ga0401205_00867616_42_323_1_2Ga0392515_0374707_186_770_1_2Ga0392514_0651723_376_960_1Ga0392515_0374707_186_770_1 Ga0392515_3593700_2_202_1_2Ga0392515_3593700_2_202_1Aggregatibacter-aphrophilus_A0A369ZCD5Aggregatibacter-aphrophilus-ATCC-33389_A0A3S4Q5U0 Ga0376351_0913968_173_517_1Ga0376351_0913968_173_517_1_2 Ga0401088_02447423_684_1268_1_2Ga0392514_0651723_376_960_1_2 CAMPEP_0198293584_Attheya-septentrionalis Aggregatibacter-aphrophilus_A0A3M6P2P9 Ga0392515_0832756_1_294_1_2Ga0392515_0832756_1_294_1Ga0376351_0397624_29_370_1_2Ga0376351_0397624_29_370_1 Ga0400921_00617249_12_356_1_2Ga0400921_00617249_12_356_1 MATOUv2_128027420_6 Aggregatibacter-sp-oral-taxon-458-str-W10330_U1QIX0 Ga0392515_2296389_2_202_1_2Ga0392515_2296389_2_202_1 Ga0392514_0697303_1070_1267_1_2Ga0392514_0697303_1070_1267_1Ga0392515_0409179_145_420_1_2Ga0392514_0455996_33_494_1Ga0376351_1076142_10_267_1Ga0392515_0409179_145_420_1 Aggregatibacter-actinomycetemcomitans-serotype-e-str-SC1083_G4A7M1Aggregatibacter-actinomycetemcomitans-RhAA1_H0KCU7 Ga0401088_01122564_573_911_1Ga0401088_01122564_573_911_1_2 Ga0392514_0455996_33_494_1_2Ga0376351_1076142_10_267_1_2Ga0392515_0639446_39_314_1_2Ga0376351_0723421_10_285_1_2Ga0376351_0280275_1_261_1_2Ga0376351_0723421_10_285_1Ga0392515_0639446_39_314_1Ga0376351_0280275_1_261_1 Haemophilus-parahaemolyticus-HK385_I3D939 Ga0401088_00831832_773_1360_1_2Ga0401088_00831832_773_1360_1Ga0376351_0739087_100_381_1_2Ga0401205_02054454_37_381_1_2Ga0376351_0739087_100_381_1Ga0401205_02054454_37_381_1Ga0376351_1324330_1_312_1_2Ga0400921_02104688_96_440_1Ga0376351_0699878_8_313_1_2Ga0376351_1324330_1_312_1Ga0376351_0699878_8_313_1 Aggregatibacter-actinomycetemcomitans_A0A142G2V1 Ga0400921_02104688_96_440_1_2Ga0400920_02052563_148_492_1_2Ga0400920_02052563_148_492_1Ga0401088_01660463_3044_3268_1 Haemophilus-ducreyi_A0A448KHT5 Ga0401088_01660463_3044_3268_1_2 Azoarcus-indigens_A0A4V3BKV2 Ga0400920_00786956_1_333_1_2Ga0400920_00786956_1_333_1MATOUv2_29363016_1MATOUv2_67426810_2 Ga0400921_02002929_130_465_1_2Ga0401205_03387565_2720_3316_1Ga0400921_02002929_130_465_1Ga0392514_0141277_2232_2828_1Ga0392515_0512129_48_497_1_2Ga0376351_0872182_458_817_1Ga0392515_0512129_48_497_1Ga0401088_01586136_2_352_1Ga0376351_3670916_8_292_1_2Ga0376351_6956554_49_273_1Ga0376351_3670916_8_292_1Ga0392515_0459026_5_604_1 Ga0401205_15233028_2_238_1 Ga0401205_03387565_2720_3316_1_2Ga0400921_00368905_740_1336_1_2Ga0392514_0141277_2232_2828_1_2Ga0400921_00368905_740_1336_1Ga0401088_01586136_2_352_1_2Ga0376351_6956554_49_273_1_2Ga0401088_02378622_28_414_1Ga0392515_0459026_5_604_1_2Ga0401205_15233028_2_238_1_2 MATOUv2_136359114_4 Ga0376351_0395325_1266_1727_1_2Ga0376351_0395325_1266_1727_1Ga0376351_0872182_458_817_1_2Ga0401205_02323896_120_413_1_2Ga0400921_01399773_606_1205_1_2Ga0401088_02378622_28_414_1_2Ga0401088_00214100_810_1409_1Ga0401205_02323896_120_413_1Ga0392514_0615958_258_857_1_2Ga0400921_01399773_606_1205_1Ga0376351_0458897_234_485_1Ga0392514_0615958_258_857_1 MATOUv2_131878983_5 Ga0401088_00214100_810_1409_1_2Ga0376351_0458897_234_485_1_2Ga0400920_02795964_751_1338_1 MATOUv2_143734756_4 Ga0400920_02795964_751_1338_1_2Ga0376351_0366135_179_766_1Ga0392515_0470183_4_603_1_2Ga0392515_0470183_4_603_1Ga0376351_0113116_25_411_1_2Ga0401205_00874802_10_396_1Ga0376351_0113116_25_411_1Ga0376351_0299061_11_397_1Ga0376351_0408989_6_299_1 Ga0376351_0366135_179_766_1_2Ga0401088_01629062_517_1116_1Ga0401205_03066879_237_623_1Ga0376351_0299061_11_397_1_2 CAMPEP_0200894262_Chaetoceros-debilisCAMPEP_0197743826_Chaetoceros-brevis Ga0401205_01496210_3973_4572_1_2Ga0400921_00025091_6703_7302_1_2Ga0392514_0194399_1425_2024_1_2Ga0401088_01629062_517_1116_1_2Ga0400921_00025091_6703_7302_1Ga0401205_01496210_3973_4572_1Ga0400920_00458591_1422_2021_1Ga0392514_0194399_1425_2024_1Ga0392515_0372249_1341_1670_1Ga0401205_03066879_237_623_1_2Ga0376351_0366074_287_499_1Ga0401205_00874802_10_396_1_2Ga0401205_00715120_100_393_1Ga0376351_0408989_6_299_1_2 Ga0400920_00458591_1422_2021_1_2Ga0392515_0372249_1341_1670_1_2Ga0376351_0366074_287_499_1_2Ga0401205_00715120_100_393_1_2Ga0376351_1597317_1308_1763_1 Microvirgula-aerodenitrificans_A0A2S0PD41 Ga0401205_02141501_833_1432_1Ga0376351_1597317_1308_1763_1_2Ga0400920_04658912_2_241_1 MATOUv2_137017955_4 CAMPEP_0187057240_Chaetoceros-curvisetus Ga0401205_02141501_833_1432_1_2Ga0400920_00431650_1395_1994_1Ga0400920_01267287_360_737_1Ga0400920_04658912_2_241_1_2 MATOUv2_134737068_5 Ga0400920_00431650_1395_1994_1_2Ga0400920_01027917_861_1442_1Ga0400920_01267287_360_737_1_2 MATOUv2_133992807_2 Ga0400920_01027917_861_1442_1_2 MATOUv2_114060405_1 Ga0400920_00577065_708_1049_1_2Ga0400920_00577065_708_1049_1Ga0400921_01916512_2_280_1_2Ga0400921_01916512_2_280_1

MATOUv2_138256141_4

Paucibacter-aquatile_A0A2N8KXH6 CAMPEP_0171301540_Proboscia-inermisCAMPEP_0171314270_Proboscia-inermis MATOUv2_68559258_1 Ga0400920_02408727_18_359_1_2Ga0400920_02408727_18_359_1Ga0376351_0107366_66_584_1_2Ga0376351_0107366_66_584_1 MATOUv2_134991538_4MATOUv2_136870326_1 Ga0401205_07750522_1_234_1_2Ga0401205_07750522_1_234_1 Dyella-sp-OK004_A0A1I6MTB3 Methylomagnum-ishizawai_A0A1Y6D3K7 MATOUv2_125895619_2MATOUv2_125895618_2 MATOUv2_127887625_5

MATOUv2_128108200_6MATOUv2_134654435_4

MATOUv2_136046095_4

MATOUv2_133668653_4

CAMPEP_0193401654_CCMP2293CCMP2293_1858619_genomic MATOUv2_65798980_4 CAMPEP_0119456886_Chaetoceros-cf.-neogracile

MATOUv2_135616437_6MATOUv2_135021497_3MATOUv2_136356994_6MATOUv2_139587241_6

MATOUv2_108706611_4

Ga0400920_01178400_182_652_1Ga0400920_01178400_182_652_1_2MATOUv2_142078032_4 MATOUv2_133739568_5 MATOUv2_67581778_6 MATOUv2_128207508_4Ga0401205_01552986_10205_10714_1Ga0401205_01552986_10205_10714_1_2Ga0400921_01497373_377_577_1_2Ga0400921_01497373_377_577_1

CAMPEP_0115796024_Chrysochromulina-polylepis Ga0400920_02015144_4805_5239_1 MATOUv2_148079115_2

Ga0400920_02015144_4805_5239_1_2 MATOUv2_134111635_6MATOUv2_131901202_5 Ga0400921_00586330_414_992_1Ga0400920_00389360_23_496_1 MATOUv2_140048642_4 MATOUv2_114816810_4

Ga0392514_0558907_5837_6415_1Ga0392515_0237068_1185_1763_1Ga0400920_00389360_23_496_1_2 MATOUv2_138889478_6 Burkholderiales-bacterium-PBB2_A0A257FSD0 Ga0400921_00586330_414_992_1_2Ga0392515_0538889_409_852_1 Paucibacter-sp-KBW04_A0A3N7DH71 MATOUv2_113560978_5MATOUv2_114579297_2 Ga0392514_0558907_5837_6415_1_2Ga0392515_0237068_1185_1763_1_2 CAMPEP_0198260432_Chaetoceros-dichaeta MATOUv2_57884462_2MATOUv2_68534509_3MATOUv2_2080449_4Ga0401205_02014590_22335_22913_1Ga0376351_0750652_14_292_1Ga0392515_0538889_409_852_1_2Ga0392514_0543415_1_303_1 CAMPEP_0119543368_Florenciella-parvula MATOUv2_57911163_5Ga0401205_02014590_22335_22913_1_2Ga0376351_0750652_14_292_1_2Ga0400921_00756182_2_481_1 MATOUv2_114200347_5 Ga0392515_3931734_26_295_1Ga0392514_0543415_1_303_1_2 Lysobacter-soli_A0A3D8VIQ5Xanthomonas-sacchari_A0A5D1A9R1Xanthomonas-sacchari_A0A0A8DZY9Xanthomonas-sacchari_A0A2P5Z812 Ga0392514_0441985_123_494_1Ga0376351_1337160_227_805_1 MATOUv2_112811805_3 Ga0400921_00756182_2_481_1_2Ga0376351_1339622_347_913_1 MATOUv2_112792103_1 Ga0400921_00414284_854_1432_1_2Ga0401088_02064948_3759_4334_1Ga0400920_01742464_1802_2380_1Ga0401205_01539923_1387_1635_1Ga0400921_00414284_854_1432_1Ga0392514_0441985_123_494_1_2Ga0376351_1337160_227_805_1_2MATOUv2_57772377_5MATOUv2_130670828_2MATOUv2_130770122_2Ga0400921_00530513_300_533_1Ga0392515_3931734_26_295_1_2Ga0392514_0653549_3_347_1Ga0400921_00046514_3_482_1Ga0376351_1480391_1_462_1Ga0376351_1339622_347_913_1_2Ga0401088_01793267_153_452_1Ga0401205_02907411_325_891_1Ga0392514_0390812_344_910_1Ga0376351_0516309_3_479_1Ga0392515_0837797_1_540_1Ga0376351_1481051_1_405_1 Alcaligenes-faecalis_A0A4P8JPJ2 Ga0401088_02064948_3759_4334_1_2Ga0400920_01742464_1802_2380_1_2Ga0401205_01539923_1387_1635_1_2Ga0400921_00530513_300_533_1_2Ga0392515_1026242_2_451_1Ga0376351_1480391_1_462_1_2Ga0400920_01051239_1_465_1Ga0401205_02907411_325_891_1_2Ga0392514_0390812_344_910_1_2Ga0376351_0516309_3_479_1_2Ga0392514_0767239_304_765_1Ga0392515_0837797_1_540_1_2Ga0376351_1481051_1_405_1_2Ga0376351_0303183_207_482_1 Rhodanobacter-fulvus-Jip2_I4W0W0 Ga0392514_0653549_3_347_1_2Ga0401088_00775805_29_400_1Ga0400921_00046514_3_482_1_2Ga0401088_01793267_153_452_1_2Ga0392514_0327232_28_600_1 Lysobacter-sp-Root494_A0A0Q7Q548 Alcaligenes-sp-EGD-AK7_U1ZVB4 Ga0392515_1026242_2_451_1_2Ga0401205_01627202_73_438_1Ga0400920_01051239_1_465_1_2Ga0400920_01186696_673_1239_1Ga0401088_00970870_258_587_1Ga0401088_01824681_1_567_1MATOUv2_69065234_4Ga0400920_00546798_2_268_1 Rhodanobacter-denitrificans_M4NFF6 Ga0400920_02034298_67_396_1Ga0401205_02322965_2232_2798_1Ga0400921_00895391_2257_2823_1Ga0392514_0767239_304_765_1_2Ga0376351_0303183_207_482_1_2Ga0376351_0517582_3_545_1 Alcaligenes-faecalis_A0A2U2BGJ6 Alcaligenes-faecalis_A0A3G6HFW2 Ga0400921_01078111_1010_1456_1Ga0401088_00775805_29_400_1_2Ga0401205_01627202_73_438_1_2Ga0401088_00970870_258_587_1_2Ga0400921_00485984_147_719_1Ga0392514_0327232_28_600_1_2 CAMPEP_0193240536_CCMP2098 Ga0400921_00333041_23_529_1Ga0392515_0294395_2944_3402_1Ga0400920_02034298_67_396_1_2Ga0400920_01186696_673_1239_1_2Ga0401088_02522725_2213_2680_1Ga0401088_01824681_1_567_1_2 Frateuria-aurantia-strain-ATCC-33424 Ga0392514_0057987_833_1510_1Ga0400921_01078111_1010_1456_1_2Ga0401205_02083494_687_1133_1Ga0401088_01981301_1820_2386_1Ga0401205_02322965_2232_2798_1_2Ga0400921_00895391_2257_2823_1_2Ga0401205_00958545_183_470_1Ga0376351_0517582_3_545_1_2 Ga0400920_00546798_2_268_1_2 Ga0400921_00333041_23_529_1_2Ga0401088_02522725_2213_2680_1_2Ga0392515_0700895_190_636_1 Alcaligenes-aquatilis_A0A3G2I044 Ga0392514_0057987_833_1510_1_2Ga0401205_01890062_620_1090_1Ga0376351_3451395_2_232_1Ga0376351_6756903_2_232_1Ga0392515_0771122_17_442_1Ga0392514_1848209_2_205_1Ga0401205_02083494_687_1133_1_2Ga0392515_0294395_2944_3402_1_2Ga0401088_01981301_1820_2386_1_2Ga0400921_00485984_147_719_1_2Ga0401205_00958545_183_470_1_2Ga0392514_0284132_388_960_1Ga0392515_0649416_132_704_1Ga0400921_01436690_147_719_1Ga0392514_0746025_72_644_1Ga0401088_00069739_9_365_1 Xanthomonas-sp-NCPPB-1128_A0A0J6ITR5 Ga0401205_01890062_620_1090_1_2Ga0376351_6756903_2_232_1_2Ga0392514_1848209_2_205_1_2Ga0392515_0700895_190_636_1_2Ga0392514_0681927_3431_4003_1 Rhodanobacter-spathiphylli-B39_I4W4A4Lysobacter-sp-SJ-36_A0A514BTB0 MATOUv2_134644857_6 Ga0376351_3451395_2_232_1_2Ga0376351_0210612_418_1002_1 Ga0401088_01590748_570_1142_1 Alcaligenes-aquatilis_A0A3R9GKM1 Ga0392515_0771122_17_442_1_2Ga0376351_0905989_4283_4855_1Ga0401205_00938573_497_1069_1Ga0392514_0284132_388_960_1_2Ga0392515_0649416_132_704_1_2Ga0400921_01436690_147_719_1_2Ga0392515_0113863_512_1084_1Ga0392514_0746025_72_644_1_2Ga0401205_01421929_490_1062_1 Ga0376351_0210612_418_1002_1_2Ga0401205_00333870_5499_6083_1Ga0392514_0681927_3431_4003_1_2Ga0401088_00069739_9_365_1_2Ga0376351_0324738_420_992_1Ga0400921_00157988_6859_7431_1 Gammaproteobacteria-bacterium_A0A534A3D6 Ga0376351_0905989_4283_4855_1_2Ga0401205_00583989_448_1020_1 Stenotrophomonas-sp-BIIR7_A0A1E7RRP0Stenotrophomonas-sp-278_A0A3R8SY47 Ga0401205_00333870_5499_6083_1_2Ga0401205_00938573_497_1069_1_2 Ga0401088_01590748_570_1142_1_2 Luteimonas-sp-Gr-4_A0A518N6R8 Ga0400920_00050277_1626_2198_1Ga0392515_0113863_512_1084_1_2Ga0400921_00157988_6859_7431_1_2Ga0401205_01421929_490_1062_1_2 Xanthomonas-oryzae_A0A0M1L058 Ga0376351_0875418_124_498_1Ga0392515_1308365_29_403_1 Ga0400921_01073248_3756_4328_1Ga0376351_0324738_420_992_1_2 Alcaligenes-faecalis_A0A3D0L1A7 Ga0392515_0504570_112_690_1 Ga0401205_00583989_448_1020_1_2 Dysgonomonas-alginatilytica_A0A2V3PST0 Stenotrophomonas-rhizophila_A0A3N1KGG6 MATOUv2_138068336_6 Stenotrophomonas-rhizophila_A0A498CG42 MATOUv2_130121118_6 Ga0376351_0875418_124_498_1_2Ga0401088_01304980_172_750_1 Xanthomonas-dyei_A0A2S7CC17 MATOUv2_110730962_2 Ga0400920_00050277_1626_2198_1_2 Stenotrophomonas-sp-LM091_A0A1D8Y7C2 Ga0400921_01880757_769_1347_1Ga0392514_0514057_1643_2221_1Ga0392515_1308365_29_403_1_2Ga0400920_13333534_3_215_1MATOUv2_42639090_1Ga0400921_01073248_3756_4328_1_2 Rhodanobacter-sp-TND4FH1_A0A4R8LC63 Alcaligenes-faecalis_A0A411T3B4 Ga0401205_00010861_1550_2128_1Ga0392515_0504570_112_690_1_2 Dysgonomonas-macrotermitis_A0A1M5HVI9 Ga0400920_01419876_1055_1633_1Ga0401088_01304980_172_750_1_2 Ga0400921_00287358_2_340_1 MATOUv2_142589115_6 Ga0400920_13333534_3_215_1_2Ga0401088_00069508_18107_18565_1 Stenotrophomonas-rhizophila_A0A1B2N6L0 Ga0400921_01880757_769_1347_1_2 Stenotrophomonas-maltophilia_A0A246HJZ0 Ga0392514_0514057_1643_2221_1_2Ga0400921_00682350_847_1122_1Ga0401088_00152982_962_1336_1Ga0392515_1072428_1607_1981_1MATOUv2_2058802_5 Ga0400921_03138249_2_217_1Ga0400921_09404655_2_217_1Ga0400921_07821805_2_217_1 Xanthomonadaceae-bacterium_A0A354Y9J8 Ga0401205_00010861_1550_2128_1_2Ga0400920_01419876_1055_1633_1_2Ga0401205_02543968_2411_2785_1Ga0401088_05570886_3_269_1Ga0400921_00287358_2_340_1_2 Ga0401088_00069508_18107_18565_1_2 Stenotrophomonas-maltophilia_A0A4S2D6Q6Stenotrophomonas-panacihumi_A0A0R0A7T3 Ga0400921_00682350_847_1122_1_2Ga0401088_00152982_962_1336_1_2Ga0401205_02543968_2411_2785_1_2Ga0400920_00303543_1459_1833_1Ga0376351_0381041_25365_25739_1Ga0392515_1072428_1607_1981_1_2 MATOUv2_126501556_5 Ga0392515_1633350_1_252_1Ga0400921_03138249_2_217_1_2Ga0400921_07821805_2_217_1_2Ga0400921_09404655_2_217_1_2 Stenotrophomonas-sp-SKA14_B8L6P3

Stenotrophomonas-terrae_A0A0R0CK03 MATOUv2_131539735_2 Ga0400920_00303543_1459_1833_1_2Ga0401088_05570886_3_269_1_2 Xanthomonas-sp-Leaf148_A0A0Q5JDI7Xanthomonas-floridensis_A0A1A9MA62 Ga0376351_0381041_25365_25739_1_2 MATOUv2_5198066_4MATOUv2_108251137_5 Stenotrophomonas-sp-BK441_A0A4Q7RWD6 Ga0392515_1633350_1_252_1_2 Pseudoxanthomonas-wuyuanensis_A0A286CWW0Lysobacter-sp-N42_A0A4R4F681 Ga0400920_02924992_3_209_1 MATOUv2_119908127_6 Stenotrophomonas-rhizophila_A0A023Y171Stenotrophomonas-pavanii_A0A246L1M2 MATOUv2_32377763_3 Xanthomonas-citri-pv-fuscans_A0A2H1S5G6 Ga0400920_02846662_11439_12005_1 Ga0392515_1075674_781_987_1 Stenotrophomonas-rhizophila_A0A4U3GB48 MATOUv2_119375617_3 Ga0392514_0256171_2038_2244_1Ga0400920_02924992_3_209_1_2 MATOUv2_138786763_2 Stenotrophomonas-sp-ASS1_A0A4P6W4M1 Dysgonomonas-capnocytophagoides_A0A4Y8L3W5 MATOUv2_158013584_6 Ga0400920_02846662_11439_12005_1_2 Stenotrophomonas-maltophilia_A0A3N1QMV6 Ga0392515_1075674_781_987_1_2 Stenotrophomonas-sp-DDT-1_A0A149PRZ1 MATOUv2_119862636_4 Ga0392514_0256171_2038_2244_1_2 Xanthomonas-translucens-pv-cerealis_A0A514EEI1bacterium-M00FCaET1770111_A0A4S0R722bacterium-M00FCaET1630111_A0A4S0Z3C5 Xanthomonas-campestris-pv-translucens_A0A561PJQ6 MATOUv2_121210255_6 Stenotrophomonas-sp-HMWF003_A0A2R7R2A5Stenotrophomonas-maltophilia_A0A1S2BFZ5 Ga0401205_02004011_1693_1899_1Ga0401088_01511182_2_205_1 Stenotrophomonas-chelatiphaga_A0A0R0CVD4Stenotrophomonas-maltophilia_A0A0M2KT23 Stenotrophomonas-maltophilia_A0A4Z0DGJ1Stenotrophomonas-maltophilia_A0A0U5HTZ5 Stenotrophomonas-sp.-SAU14A_A0A3Q8FH58 MATOUv2_138837144_2 Ga0376351_0129285_24636_24842_1 Stenotrophomonas-maltophilia_A0A0M1EKR8Stenotrophomonas-maltophilia_A0A4T1DEI0Stenotrophomonas-maltophilia_A0A2W6NIW9 MATOUv2_114632311_6MATOUv2_112994584_1

Stenotrophomonas-maltophilia_A0A2W5HBX7 MATOUv2_108540366_6 Stenotrophomonas-maltophilia_A0A2J0UQK1 Ga0401088_00051421_11869_12075_1Ga0401205_02004011_1693_1899_1_2 Stenotrophomonas-sp.-ESTM1D_A0A3S7KTN0 MATOUv2_112527872_4 Ga0401088_01079665_3_296_1 Ga0401088_01511182_2_205_1_2 Stenotrophomonas-daejeonensis_A0A0R0DDR4Stenotrophomonas-sp-CC22-02_A0A4R7UKU8 Ga0392515_0240603_25_312_1 Stenotrophomonas-maltophilia-RA8_M5D1H5 Ga0376351_0129285_24636_24842_1_2 Stenotrophomonas-maltophilia-SKK35_M5CQL8 uncultured-bacterium_A0A1Y0BLX2 MATOUv2_38323384_6 MATOUv2_152262900_6 MATOUv2_123669456_1MATOUv2_5751614_2 Ga0401088_01079665_3_296_1_2 Ga0401088_00051421_11869_12075_1_2Ga0400920_06260284_13_222_1Ga0400920_08706117_13_222_1 Stenotrophomonas-sp-KCTC-12332_A0A126NJQ3 MATOUv2_5221348_6 Ga0392515_0240603_25_312_1_2 Ga0400920_04220728_13_222_1 Pseudoxanthomonas-sp-NML171200_A0A4Q8L4E0 MATOUv2_145066040_4

MATOUv2_111336457_4 Pseudoxanthomonas-sp-NML171202_A0A4V2HDJ1 MATOUv2_145108038_5 Pseudoxanthomonas-sp-NML171590_A0A4V2KK55Pseudoxanthomonas-sp-NML140781_A0A4Q8LZ83 Stenotrophomonas-maltophilia-Ab55555_J7UWH9 CAMPEP_0193204522_CCMP2098MATOUv2_142004787_5MATOUv2_119699205_6 Pseudoxanthomonas-sp-GM95_A0A1H7L0M4 MATOUv2_120616331_6MATOUv2_120981009_5MATOUv2_120981010_5MATOUv2_126176518_5MATOUv2_121122886_4 Ga0400920_06260284_13_222_1_2Ga0400920_08706117_13_222_1_2 Pseudoxanthomonas-composti_A0A4V1N1C5 MATOUv2_108091837_1 Ga0400921_00262128_1032_1673_1 Ga0400920_04220728_13_222_1_2 MATOUv2_111336456_4MATOUv2_114436838_1 Mesorhizobium-sp-M00FCaET1700111_A0A4S0VJ32 MATOUv2_114331216_3 Pseudoxanthomonas-sp-NML130969_A0A4Q8M7B4Pseudoxanthomonas-suwonensis_A0A0E3Z4N3 Stenotrophomonas-sp-CC120222-04_A0A239Q429Mesorhizobium-sp-M00FCaET1510111_A0A5R2L018 Ga0376351_3933756_14_280_1 MATOUv2_112179815_6MATOUv2_110363247_4 Ga0400921_00262128_1032_1673_1_2 Xanthomonas-citri-pv-phaseoli-var-fuscans_A0A2D2RNJ3Stenotrophomonas-maltophilia-strain-K279a_B2FPU0 Ga0392515_2703840_3_194_1Ga0400920_00618069_61508_62095_1 Ga0401088_00173835_407_616_1 MATOUv2_108423754_4 Ga0376351_3933756_14_280_1_2 Ga0392515_0306647_1853_2062_1 Ga0400920_00618069_61508_62095_1_2 Ga0392514_1738065_1_195_1 CAMPEP_0193153044_CCMP2097 Ga0392515_2703840_3_194_1_2 Ga0400920_02585899_3865_4293_1 Ga0401088_00173835_407_616_1_2 Ga0400920_01614579_311_826_1 Ga0400920_01321298_53_262_1Ga0400921_00866884_372_578_1Ga0400920_00449249_197_403_1Ga0401205_03383119_32_244_1Ga0400920_00221699_176_388_1 MATOUv2_120370640_5MATOUv2_133941659_6 Ga0392515_0378084_2278_2490_1 Stenotrophomonas-maltophilia-strain-R551-3_B4SRH1 Ga0376351_0526013_3_452_1Ga0400920_02114587_1_315_1 Ga0392515_0306647_1853_2062_1_2Ga0392514_1738065_1_195_1_2Ga0392515_0932730_3129_3335_1Ga0376351_0551909_1559_1765_1Ga0401088_00298589_165_377_1 Ga0376351_0900169_3_452_1Ga0400921_00977195_1_306_1Ga0376351_0205281_584_919_1 Ga0400920_02585899_3865_4293_1_2 Ga0401088_00120345_8_217_1Ga0400920_00221699_176_388_1_2Ga0400920_01636877_176_388_1 Pseudoxanthomonas-spadix_A0A3M6Q767 Ga0392514_0182515_127_411_1Ga0376351_0579959_170_526_1Ga0400920_01614579_311_826_1_2 Ga0400920_01321298_53_262_1_2Ga0401088_00419583_4398_4604_1Ga0400921_00866884_372_578_1_2Ga0400920_00449249_197_403_1_2Ga0392515_0892118_47_259_1Ga0401205_03383119_32_244_1_2Ga0401205_01574124_1330_1539_1 MATOUv2_115481394_5 Ga0376351_0526013_3_452_1_2Ga0392514_0233570_239_760_1Ga0401088_01399299_494_850_1Ga0376351_0818701_238_462_1Ga0400920_01781952_8_232_1Ga0401205_01269235_118_378_1Ga0400920_02114587_1_315_1_2Ga0400921_01321669_6599_7114_1 Ga0392515_0716854_550_759_1Ga0376351_1506198_2711_2923_1 Xanthomonadaceae-bacterium_A0A5C7S3D8 Ga0376351_0900169_3_452_1_2Ga0400921_00977195_1_306_1_2Ga0392515_1028073_2430_2786_1Ga0376351_0136289_2907_3263_1Ga0400920_01957265_119_343_1Ga0401088_01427885_203_550_1Ga0376351_0205281_584_919_1_2 Ga0392515_0932730_3129_3335_1_2Ga0376351_0551909_1559_1765_1_2Ga0401088_00298589_165_377_1_2Ga0392515_0378084_2278_2490_1_2 Ga0392514_0182515_127_411_1_2 Ga0400920_01636877_176_388_1_2 Pseudoxanthomonas-suwonensis_A0A2W4Y429 Ga0392514_0233570_239_760_1_2Ga0400921_01020493_2297_2653_1Ga0401088_01399299_494_850_1_2Ga0401205_01546188_890_1246_1Ga0400920_02187039_3_398_1Ga0392515_0524840_1923_2279_1Ga0376351_0288040_1282_1638_1Ga0400920_01781952_8_232_1_2Ga0376351_0579959_170_526_1_2Ga0400921_01321669_6599_7114_1_2 Ga0400920_00825874_351_560_1Ga0401088_00120345_8_217_1_2Ga0392515_0892118_47_259_1_2 Ga0392515_0477526_2325_2996_1Ga0401205_03515592_2597_2953_1Ga0400920_00053374_1888_2244_1Ga0392514_0189671_1193_1549_1Ga0401088_01700896_769_1125_1Ga0376351_0818701_238_462_1_2Ga0401205_01269235_118_378_1_2 Ga0400920_00346751_3594_3800_1Ga0401088_00419583_4398_4604_1_2Ga0401088_00160370_92_304_1Ga0401088_01321941_92_304_1Ga0376351_1506198_2711_2923_1_2Ga0401205_01574124_1330_1539_1_2 Ga0401205_00217517_1272_1943_1Ga0400920_01273468_4706_5377_1Ga0401088_01100866_1702_2373_1Ga0392515_1028073_2430_2786_1_2Ga0376351_0136289_2907_3263_1_2Ga0400920_02187039_3_398_1_2Ga0392515_0524840_1923_2279_1_2Ga0400921_00682511_2232_2588_1Ga0400920_01957265_119_343_1_2Ga0401205_01517742_8821_9177_1Ga0401088_01427885_203_550_1_2 Ga0400921_00615556_916_1125_1Ga0392515_0716854_550_759_1_2 CCMP2436_62407_genomic Ga0392515_0477526_2325_2996_1_2Ga0401205_03515592_2597_2953_1_2Ga0400921_01020493_2297_2653_1_2Ga0401205_01546188_890_1246_1_2Ga0376351_0288040_1282_1638_1_2Ga0392514_0189671_1193_1549_1_2Ga0401088_01700896_769_1125_1_2 Ga0400920_00825874_351_560_1_2 Ga0401205_00217517_1272_1943_1_2Ga0400920_00053374_1888_2244_1_2Ga0400921_00682511_2232_2588_1_2Ga0400921_04114702_17_238_1 Ga0401205_03412562_3548_3757_1Ga0400920_00346751_3594_3800_1_2Ga0392514_0366973_1386_1598_1Ga0401088_00160370_92_304_1_2Ga0401088_01321941_92_304_1_2 Ga0400920_01273468_4706_5377_1_2Ga0401088_01100866_1702_2373_1_2Ga0401205_01517742_8821_9177_1_2 Ga0400921_00615556_916_1125_1_2Ga0392515_0039765_2523_2735_1 MATOUv2_156876720_4 Ga0401205_02738321_3_356_1Ga0400921_04114702_17_238_1_2 Ga0400920_00104485_453_665_1Ga0401205_03412562_3548_3757_1_2Ga0400920_07675786_35_229_1Ga0400921_01041284_5047_5259_1Ga0401205_01756451_2150_2362_1Ga0400920_00792563_1060_1272_1 Ga0392514_0366973_1386_1598_1_2Ga0392515_0039765_2523_2735_1_2 Ga0401205_02738321_3_356_1_2 Ga0400920_07675786_35_229_1_2 Ga0400920_00104485_453_665_1_2Ga0400920_00792563_1060_1272_1_2Ga0401205_01756451_2150_2362_1_2Ga0400921_01041284_5047_5259_1_2 Pseudoxanthomonas-spadix-strain-BD-a59_G7UWI5 Ga0400920_02495243_1_357_1 Ga0392515_0798594_429_785_1Ga0400921_00009785_134_685_1Ga0400920_00888196_124_588_1Ga0401205_00867974_276_827_1 Ga0400920_02495243_1_357_1_2Ga0392514_0045791_398_730_1Ga0392515_1298329_2590_3141_1Ga0401088_02004195_128_679_1 Ga0400921_00160624_3557_3850_1 Ga0401088_02376312_148_504_1Ga0400921_00009785_134_685_1_2Ga0376351_0512467_8541_9092_1Ga0392514_0666045_4075_4626_1Ga0401205_00867974_276_827_1_2 Ga0392515_0798594_429_785_1_2Ga0392514_0045791_398_730_1_2Ga0400920_00888196_124_588_1_2 CAMPEP_0173019328_Phaeocystis_antrctica Ga0400921_00205693_1778_2134_1Ga0392515_1298329_2590_3141_1_2Ga0376351_0512467_8541_9092_1_2Ga0401088_02004195_128_679_1_2 Ga0400921_00160624_3557_3850_1_2 Ga0401088_02376312_148_504_1_2Ga0392514_0666045_4075_4626_1_2 Pseudomonas-geniculata-N1_A0A0L8A8F4_Pseudomonas-geniculata-N1 CAMPEP_0198176926_Phaeocystis_antarctica Ga0400921_00205693_1778_2134_1_2 Ga0400920_02444791_308_517_1

MATOUv2_128144488_5

Ga0400920_02444791_308_517_1_2Ga0392515_0712807_83_292_1

Ga0392515_0712807_83_292_1_2

MATOUv2_47464053_2 Ga0400921_01041022_199_390_1Ga0401205_02179284_157_348_1Ga0401088_00043037_146_337_1 MATOUv2_65790197_6 MATOUv2_140254981_5MATOUv2_128807306_5 Ga0400921_01041022_199_390_1_2Ga0401205_02179284_157_348_1_2Ga0401088_00043037_146_337_1_2

MATOUv2_16402427_5MATOUv2_136764667_6

MATOUv2_128144488_4 MATOUv2_2203441_6 MATOUv2_11312706_6

MATOUv2_134042778_4

Ga0392515_1124291_309_497_1

Ga0392515_1124291_309_497_1_2

MATOUv2_138227034_4

Key --- Diatoms --- Pelagophytes --- Dictyochophytes --- Chrysophytes --- Cryptomonads --- Haptophytes --- Chlorophytes --- Dinoflagellates --- Other eukaryotes --- Bacteria

Arctic native sequence Antarctic native sequence Bipolar Arctic/ Antarctic (TARA data only)

1052

1053 Fig. 5- Figure Supplement 4. Diversity and polar horizontal gene transfers of PhnA domains. This 1054 figure summarises the consensus best-scoring tree topology obtained with RaxML under GTR, JTT 1055 and WAG substitution models for a 2934 branch x 113 aa alignment of all PhnA domains (PF03831) 1056 sampled from UniRef, jgi algal genomes, MMETSP, Tara Oceans, and an independent transcriptome 1057 survey of Baffin Island Northwater communities. Branches are shaded by evolutionary origin and leaf 1058 nodes by biogeography (either: isolation location of cultured accessions where recorded; or on 1059 oceanic regions for which > 70% total abundance of each Tara meta-gene could be recorded). Thick 1060 branches indicate presence of a clade in all three best-scoring tree outputs. Top: overview of the 1061 global topology obtained; bottom: magnified topology of a single clade showing evidence of 1062 horizontal gene transfer between Arctic- and Antarctic eukaryotic algae. A well-supported clade of 1063 Arctic pelagophyte (CCMP2097) and dictyochophyte (CCMP2098) sequences is shown with a red 1064 circle.

1065

0.5 A Arctic query genome non-Arctic query genome from same algal group

Best hits, LAST search

Mixed library of Arctic/ non-Arctic reference genome/ transcriptomes from different algal group

Frequencies of each reference species in LAST best hits tabulated Linear regression of frequency of reference species amongst LAST best hits of Arctic query v non-Arctic query

Species over-enriched in Arctic query best hits Species that follow compared to regression linear regression

Reference species enriched in Arctic genes Other reference species B (i) Pelagophyte query v haptophyte references (ii) Haptophyte query v pelagophyte references

tobin

anophageferrens

Novel pelagophyte CCMP2097 Pavlovales sp. CCMP2436 Chrysochromulina Aureococcus

Novel pelagophyte CCMP2097 Pavlovales sp. CCMP2436

(iii) Pelagophyte query v chlorophyte references (iv) Chrysophyte query v chlorophyte references

anophageferrens

Pyramimonas sp. CCMP2087 gaditana Nannochloropsis Aureococcus

Novel pelagophyte CCMP2097 Ochromonas sp. CCMP2298

(v) Cryptomonad query v dictyochophyte references (vi) Pelagophyte query v dictyochophyte refs.

theta

anophageferrens

Guillardia Aureococcus Arctic dictyochophyte CCMP2098

Baffinella sp. CCMP2293 Novel pelagophyte CCMP2097 1066 Arctic reference species/ Antarctic reference species/ Other reference species

1067 Fig. 6- Figure Supplement 1. Identification of species enriched in Arctic-specific genes by LAST best 1068 hit search. A: Outline of the methodology used. Two query genomes (one Arctic, one not) from a 1069 query algal genome are searched against a mixed library of sequences from another algal group by 1070 LAST. As the query genomes are the same phylogenetic distance from the reference group each 1071 reference species should be retrieved as a LAST best hit a proportionate number of times by each 1072 query, with references that deviate from a linear relationship enriched in Arctic-specific genes. B: 1073 exemplar scatterplots of the number of LAST best hits obtained with Arctic (horizontal) and non- 1074 Arctic (vertical) queries against different algal groups; showing (i, ii) a bidirectional enrichment in 1075 LAST best hits between Pavlovales sp. CCMP2436 and the novel pelagophyte CCMP2097 in searches 1076 between haptophyte and pelagophyte libraries; (iii, iv) an enrichment in Pyramimonas sp. CCMP2087 1077 in LAST best hits with Arctic pelagophyte and chrysophyte queries; and (v, vi) an enrichment in the 1078 Arctic dictychophyte CCMP2098 in LAST best hits with Arctic cryptomonad and pelagophyte queries.

Complete genomes for all four Arctic species CCMP2293: 33051 genes; CCMP2436: 26034 genes; CCMP2298: 20195 genes; CCMP2097: 19402 genes

Search by BLASTp against all tree of life (uniref, MMETSP, 1kp) excluding query sequence; perform reciprocal BLASTp best hit search against corresponding MMETSP transcriptome library of species.

filtration filtration Extract genes with (1) reciprocal BLAST best hit to MMETSP transcript and (2) presence on same scaffold as at least one gene with non-self BLAST best hit congruent with vertical inheritance (Baffinella sp. CCMP2293: cryptomonads; Pavlovales sp. CCMP2436- haptophytes; CCMP2097 and Ochromonas sp. CCMP2298 - stramenopiles) Genome 1) CCMP2293: 8830 genes; CCMP2436: 11567 genes; CCMP2298: 3056 genes; CCMP2097: 10691 genes

- Search genes using LAST against combined jgi genome and MMETSP transcriptome libraries for eight algal groups (chlorophytes, chrysophyte-related species, cryptomonads, diatoms, dictyochophytes, dinoflagellates, haptophytes, pelagophytes). search Within Extract genes with LAST best hit against at least one Arctic native algal species in one of the 2)

algal above searches CCMP2293: 245 genes; CCMP2436: 298 genes; CCMP2298: 220 genes; CCMP2097: 559 genes

Perform LAST search and retrieve best hits for extracted genes for: • All tree of life library, decomposed into 151 unique taxonomic categories, and annotated with habitat (Arctic, Antarctic, Other)

search • All chlorophyte, chrysophyte, cryptomonad, diatom, dictyochophyte, dinoflagellate, haptophyte, pelagophyte libraries • 85 further reference prokaryotic and eukaryotic genomes

of life life of Search query gene against pooled LAST best hits by BLASTp. Filter for:

tree • Genes receiving a best non-self hit to an Arctic or Antarctic native species • Genes receiving a best non-self hit to a non-vertical taxonomic category (CCMP2293- not cryptomonads; CCMP2436- not haptophytes; CCMP2097- not pelagophytes; CCMP2298-

3) All- 3) not chrysophyte-related taxa) CCMP2293: 43 genes; CCMP2436: 38 genes; CCMP2298: 36 genes; CCMP2097: 112 genes

Search retained gene cluster query sequences against one another, and against full genome and transcriptome libraries for each query species by BLASTp.

Incorporate all sequences found to be better than the best non-self hit into each cluster. Merging Merge clusters more closely related to one another, inferred by BLAST hit, to respective best 4) non-Arctic, non-self hit

215 merged gene clusters

Align merged sequence clusters with mafft, using automated settings. Manually remove poorly aligned or highly divergent branches, and build guide NJ tree. Eliminate any clusters from which query gene removed or found in NJ tree to have vertical origin (Baffinella sp. CCMP2293- non-polar cryptomonads; Pavlovales sp. CCMP2436- non-polar haptophytes; CCMP2097- non-polar pelagophytes; Ochromonas sp.CCMP2298- non-polar chrysophytes)

Trim curated clusters with trimal using –gt 0.5 setting. Repeat mafft alignment, tree building, Alignment and manual editing

5) Trim curated clusters with trimal using resoverlap 0.75 -seqoverlap 0.8 setting. Repeat mafft alignment, tree building, and manual editing, removing partial query sequences as well.

129 finalised gene clusters

Pass finalised alignments through 300 replicate RAxML trees using PROTGAMMAJTT substitution model; extract best-scoring tree

Identify tree topologies with resolved Arctic-Arctic species pairs with RAxML bootstrap

Phylogeny support > 50% 6)

21 gene trees showing specific within-Arctic HGT; 13 gene trees showing unresolved polar-specific clades 1079

1080 Fig. 6- Figure Supplement 2. Pipeline of the phylogenomic approach used to identify within-Arctic 1081 HGTs in Arctic algal genomes.

1082

1083

1084 Fig. 6- Figure Supplement 3. Eight exemplar within-Arctic HGT clusters identified by whole-genome 1085 phylogenetic profiling. The tree topologies shown consist of the proposed within Arctic-HGT clade 1086 and its two closest sister-groups; full tree topologies for these and 26 additional identified within- 1087 Arctic HGT trees are shown in Table S4, Sheet 9; and full nexus format tree topologies prepared using 1088 the same graphical format as detailed below are available through https://osf.io/3pmxb/files (Dorrell 1089 et al., 2021b) in «Supporting data > Exemplar within-Arctic HGT trees ». Branches are shaded by 1090 phylogenetic origin, leaves by biogeographical origin, and nodes resolving within-Arctic HGT events 1091 with > 50% bootstrap support are identified with coloured circles.

(ii) ASAFind (i) Any secreted protein 100% Signal P positive, 100% 4097 80% 160 21 plastid 12 60% SignalP positive, 40% non-plastid 80% 20% Signal P negative 24 0% 94 (iii) HECTAR 941 26555 100% 60% Plastid 5793 265 80% 40 21 Signal peptide 60% Signal anchor 40% 40% Mitochondria 20% Cytoplasm 0% 23 (iv) WolfPSort 20% 48 100% 332 3937 138 20 7544 8 80% Secreted 0% 60% Plasma Membrane Mitochondria 40% Cytoplasm 20% Nucleus

No secretory prediction Secretory prediction

(v) Any secreted protein- by species

100%

80% 7 11 4 2 8928 7840 60% 7247 2540

40%

9 11 20% 2 1 2628 2840 1572 504 0%

Secretory prediction No secretory prediction 1092

1093 Fig. 6- Figure Supplement 4. Secretory bias in within-Arctic HGTs. Bar charts showing (i-iv) the 1094 targeting predictions of all proteins in all Arctic algal genomes inspected for within-Arctic HGT; the 1095 total number of proteins yielding Arctic LAST or BLAST best hits per Fig. 6- figure supplement 2; and 1096 the total non-redundant proteins attributed to within Arctic-HGT; and (v) the total number of 1097 inspected proteins, and phylogenetically verified within-Arctic HGTs for each species. Targeting 1098 predictions were performed using ASAFind with SignalP v 3.0 (Gruber, Rocap, Kroth, Armbrust, & 1099 Mock, 2015), HECTAR under default conditions (Gschloessl, Guermeur, & Cock, 2008), and WolfPSort, 1100 with consensus animal, plant and fungal reference datasets (Horton et al., 2007) with proteins 1101 inferred to have a signal peptide and non-plastid prediction by either ASAFind or HECTAR, or an 1102 extracellular prediction by WolfPSort, inferred to be potentially secreted proteins.

1103

1104

1105 Fig. 6- Figure Supplement 5. Environmental distributions of Tara Oceans meta-transcriptome 1106 homologues of six exemplar gene clusters phylogenetically inferred to have undergone within- 1107 Arctic HGT. This figure provides distributions for the environmental equivalents of within- Arctic HGT 1108 clade identified in Table S4, Sheet 9, as resolved by a combined hmmer, BLAST best-hit, MAFFT 1109 alignment and NJ tree pipeline. Total relative abundances are provided for all size fractions, and at 1110 both surface and deep chlorophyll maximum depth samples. Complete tabulated homologue 1111 sequences and abundances for all tractable genes in both meta-genome and meta-transcriptome 1112 data are presented in Table S4, sheets 10-11; and individual plots of total relative abundances and 1113 individual relative abundances for each phylogenetically reconciled gene are available through 1114 https://osf.io/3pmxb/files (Dorrell et al., 2021b) in «Supporting data > Within-Arctic HGTs > TARA 1115 distributions ».

1116

1117

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1472

Rhodomonas

Bafnella

Cryptomonas paramecium

Guillardia theta Geminigera cryophila sp. CCMP2293

sp. CCMP768 Hemiselmis spp.

spp. sp. SE3 sp. CCMP681/ICE-L

Emiliania huxleyi

spp. RHODOPHYTES

Prasinoderma coloniale Chloropicon

Tetraselmis sp. CCMP2087 Coccomyxa Prymnesium parvum Chlorella vulgaris Chrysochromulina tobin Picochlorum Volvox carteri Chlamydomonas reinhardtii Chlamydomonas RCC288 Phaeocystis antarctica Pycnococcus provasolii SL-174, CCMP1436

98 Pavlovales sp. CCMP2436 Pyramimonas

GLAUCOPHYTES STREPTOPHYTES RCC2306, CCMPP2099 Diacronema lutheri Ostreococcus lucimarinus Bathycoccus prasinos

CRYPTOMONADS Mantoniella beaufortii Thalassiosira rotula Mantoniella antarctica Micromonas polaris CENTROHELIDS Micromonas pusilla HAPTOPHYTES Thalassiosira oceanica Skeletonema marinoi DIATOMS

Thalassiosira pseudonana CHLOROPHYTES OBAZOA, AMOEBOZOA RHIZARIA

CILIATES Chaetoceros neogracileRCC1993 APICOMPLEXA ChaetocerosMM31A debilis 97 Noctiluca scintillans Chaetoceros dichaeta 97 98 Eucampia antarctica CHRYSOPHYTE-REL. Karenia brevis RCC2770 DINOFLAGELLATES Minutocellus polymorphus

DICTYO. Dinophysis acuminata

Gonyaulax spinifera

OOMYCETES Alexandrium C25,C3 PELAGOPHYTES 89 92 Heterocapsa arctica spp. Pseudo-nitzschiaF. kerguelensis multiseries Scrippsiella hangoei Peridinium aciculiferum Polarella glacialis Fragilariopsis cylindrus Polarella glacialis Symbiodinium minutum S. kawagutii sp. CCMP2396 Pinguiococcus pyrenoidosusS. microadriaticum

Ochromonas Ochromonas L+B (-like) NannochloropsisNannochloropsis gaditana oceanica Novel dictyochophyte CCMP2098 CCMP1383 Entomoneis CCMP2088 Synedropsis recta Phaeodactylum tricornutum Thalassiothrix antarctica

sp. CCMP1393 sp. CCMP2298 Proboscia alata

Proboscia inermis Attheya septentrionalis 0.1 substitutions/site

Pelagomonas calceolata Algal genome sequenced in this study Corethron pennatum Previously sequenced algal genome 91 Consensus support (85-99%) Aureococcus anophageferens Arctic species / Antarctic species / Other

Novel pelagophyte CCMP2097 Arctic Antarctic/ Southern Ocean 100% 1000 100 . CCMP2298 . sp

10 (iii) 16Sv4v5 (iii) ) Ochromonas

● 0% 1 0 ribotypes 90 60 30 -30 -60 -90 100% 10000 pelagophyte CCMP2097 pelagophyte 1000 (parts per million total total (parts permillion

Novel

● 100 ribotypes

(ii) 18Sv9 (ii) 10 mapped . CCMP2436 .

0% 1 0 30 90 60 -90 -30 -60 number Pavlovales

● 100% Relative 1000 100 . CCMP2293 . sp

(i) 18Sv4 (i) 10 Baffinella

0% 1

30 60

-90

-60 -30 ** Genomes

* Genome comparisons **

0.7 Key 0.7

Arctic-Arctic 0.6 Arctic-Other Other-Other 0.5 0.5

Curtis value Arctic-Antarctic − Antarctic-Antarctic Bray 0.4 * P < 0.05 ** P < 0.01 0.3 0.3 n=4 *** P < 10-05 Transcriptomen=6 comparisonsn=54 n=86 Arctic−Arctic Arctic−Other Other−Other Arctic−Antarctic * Transcriptomes**** *******

**** 0.9 *** 0.9 *****

0.6 0.6 Curtis value PFAM Bray-Curtis value PFAM − Bray

0.3 0.3

0.0 n=92 n=2444 n=15976 n=248 n=139

Arctic−Arctic Arctic−Other Other−Other Arctic−Antarctic Antarctic−Antarctic 15 30

PF13366, DE(X)K PF11999, Nuclease ice-binding 25 PF06309, Torsin 25 30 10 PF13482, RNase H

PF10551, MULE PF01667, rps27 transposase PF11028, DUF2723 5 PF13879, KIAA1340

PF03831, PhnA PF14311, Zn Ribbon PF09876, DUF2103 PF06185, YecM 0 PF03988, DUF347 -5 0 5 PF06507, Auxin 10 15 -Log10 P(enrichment in PFAM presence) response factor

PF01232, Mannitol Key -5 dehydrogenase P (contractions -expansions) (contractions P

10 u PFAM associated with Arctic species PF10239, DUF2465 u PFAM contracted in Arctic species . Log diff

-10 PF00665, Integrase Polarella glacialis CCMP2088 (13) P. glacialis CCMP1383 (10) Pelagophyceae sp. CCMP2097 (23)

Pavlovales sp. Pedospumella CCMP2436 (1) encystans (48) Arctic B Heterocapsa arctica (6) 0.2

Streptomyces spp.

Arctic A Scrippsiella 0.2 hangoei-like (6) Peridinium aciculiferum (1) Ochromonas sp. CCMP2298 (54)

Pavlovales sp. CCMP2436 (40) Dictyochophyceae sp. CCMP2098 (6) Banella sp. Heterocapsa CCMP2293 (23) arctica (1)

Pyramimonas sp. (7) Pyramimonas gelidicola (2) Chaetoceros dichaeta (1) Arctic B Proboscia inermis (1), Thalassionema Micromonas P. alata (1) nitzschioides (1) polaris Attheya sp. (1) CCMP2099 Amphora sp. (1) Pavlovales sp. (2) Amphora sp. (1) CCMP2436 (72)

Dictyochophyceae CCMP2098 (8) Entomoneis sp. (1)

Arctic D Arctic C Arctic A 0.2 0.3 Antarctic 2 Arctic C Antarctic 1 Arctic D 0.2

Thalassiosira antarctica (9)

Glaciozyma antarctica Leucosporidium sp. Antarctic 2 Typhula 0.2 ishikarensis

Proboscia alata (4), Mantoniella antarctica (18), P. inermis (2) Mantoniella sp. (12) Fragilariopsis kerguelensis (1)

F. cylindrus (6) FUNGI

Phaeocystis antarctica (14) Antarctic 1 Geminigera cryophila (9), 0.2 Geminigera sp. (9)

outgroup Diatoms Arctic Pelagophytes Antarctic Dictyochophytes Bi-polar (Tara data) Chrysophytes *Other sites Cryptomonads Haptophytes substitutions/site Phaeocystis antarctica (17) * Chlorophytes Dinof agellates Other eukaryotes Consensus of JTT and WAG Nitzschia stellata (1) Navicula MATOU topologies: Chaetoceros glaciei (5) Eucampia antarctica (3) no dichaeta (6) Bacteria F. kerguelensis (2) Chaetoceros neogracilis (2) yes Proboscia inermis (1) F. cylindrus (2) clade root 80 Key Ochromonas CCMP2298 Phylogenetic origin: Biogeography: 60 Cryptomonads ¢ Arctic Pyramimonas CCMP2087 Chlorophytes u Antarctic Pelagophyte CCMP2097 Chrysophyte-related n Other Diatoms 40 Baffinella CCMP2293 Dictyochophytes Dictyochophyte CCMP2098 Dinoflagellates Haptophytes Pelagophytes 20

0 -100 -80 -60 -40 -20 0 20 40 60 80 Mean enrichment in LAST best hits, Arctic v non-Arctic query Pavlovales CCMP2436

-20

-40 Median enrichment in LAST best hits, Arcticquery vnon-Arctic besthits, LAST enrichmentin Median

-60

-80 90

Sequenced Arctic species

30 Sampling latitude latitude Sampling

0 -5 0 5 10 15 20 25 30 35 Sequenced/ known viable temperature (°C)

-30

-60 Chrysophytes Cryptomonads Diatoms Dictyochophytes Dinoflagellates Green Algae Haptophytes Pelagophytes Tara Arctic Ocean Stations Tara Southern Ocean Stations Other Tara Stations

-90 (i) 18S tree

KC928312.1_Chroomonas_coerulea_voucher_HB2011_2co

CAMNT_0016201403_Hemiselmis_tepida_Strain_CCMP443

CAMNT_0014376833_Hemiselmis_virescens_Strain_PCC157

AB240963.1_Chroomonas_caudata_gene_for

MF179477.1_Hemiselmis_virescens_voucher_RCC_3575 AB240961.1_Chroomonas_dispersa_gene_for

HG328381.1_Chroomonas_coerulea_partial

AF508268.1_Chroomonas_mesostigmatica HG328379.1_Chroomonas_caudata_partial

CAMNT_0012746751_Hemiselmis_andersenii_Strain_CCMP441AJ420698.1_Chroomonas_sp_SAG_B980_1

AM901362.1_Hemiselmis_cf_virescens_partial

JF791076.1_Hemiselmis_virescens_clone_1119 AM901358.1_Komma_caudata_partial

JF790984.1_Hemiselmis_rufescens_clone_1121AM901352.1_Hemiselmis_pacifica_partial

MF179476.1_Hemiselmis_sp_KL_2018_voucher_RCC_4102 U53122.1_Komma_caudata AM901351.1_Hemiselmis_andersenii_partial AM901367.1_Hemiselmis_sp_UTEX_2000_partial

AJ007283.1_Hemiselmis_rufescens CAMNT_0014436777_Hemiselmis_rufescens_Strain_PCC563 EF195737.1_Cryptophyta_sp_CR_MAL03 KF907399.1_Cryptomonas_pyrenoidifera_strain_CNUCRY_189 HM126533.1_Hemiselmis_tepida_strain_CCMP442 KF907395.1_Cryptomonas_pyrenoidifera_strain_CNUCRY_138 CAMNT_0053636575_Chroomonas_mesostigmatica_cf_CCMP1168 CAMNT_0012759979_Rhodomonas_salina_Strain_CCMP1319 JX490054.1_Cryptomonas_obovata_voucher_HB_2010_7 MF179474.1_Hemiselmis_rufescens_voucher_RCC_4216 JN934672.1_Rhodomonas_sp_RCC2020 AF508274.1_Rhodomonas_maculata AB240959.1_Rhodomonas_falcata_gene_for EF195733.1_Cryptophyta_sp_CR_MAL06CAMNT_0035613277_Rhodomonas_sp_CCMP768_ AB240964.1_Pyrenomonas_helgolandii_gene_forCAMNT_0023408105_Rhodomonas_abbreviata_Strain_Caron_Lab_IsolateEU163586.1_Cryptomonas_marssonii_strain_WCK01 AJ007284.1_Hemiselmis_virescens U53128.1_Rhodomonas_abbreviata

AM901345.1_Chroomonas_placoidea_partial HG328376.1_Chroomonas_africana_partial (ii) 16S tree

AM901346.1_Chroomonas_pauciplastida_partial AM901347.1_Chroomonas_mesostigmatica_partial JN050857.1_Urgorri_complanatus_strain_Cr1EHUKF907397.1_Cryptomonas_pyrenoidifera_strain_CNUCRY_166 KC928306.1_Cryptomonas_reflexa_voucher_HB2011_2re AF508270.1_Cryptomonas_ovata AM901349.1_Hemiselmis_rufescens_partial U53132.1_Rhinomonas_pauca AF508273.1_Rhinomonas_sp AB240954.1_Cryptomonas_tetrapyrenoidosa_gene_for AM901354.1_Hemiselmis_cryptochromatica_partial KF907409.1_Cryptomonas_tetrapyrenoidosa_strain_Hudong12610D KY860574.1_Chroomonas_mesostigmatica_CCMP1168 AJ007282.1_Hemiselmis_brunnescens KF907389.1_Cryptomonas_phaseolus_strain_CNUCRY_5 FR850018.1_Chroomonas_sp_WE_2011_partial HM126534.1_Chroomonas_vectensis_strain_K_0432 KF907388.1_Cryptomonas_phaseolus_strain_Changdang111311E AM051190.2_Cryptomonas_lundii_partial KF907380.1_Cryptomonas_gyropyrenoidosa_strain_CNUCRY_146 AM901360.1_Chroomonas_gentoftensis_partial LC082204.1_Chroomonas_sp_OnL01 KF907385.1_Cryptomonas_ovata_strain_CNUCRY_231 LC082200.1_Chroomonas_sp_Dc01 AB240953.1_Cryptomonas_rostratiformis_gene_for AJ420699.1_Chroomonas_sp_M1703 AB240955.1_Cryptomonas_paramecium_gene_for LC082205.1_Chroomonas_sp_Or05 AJ007279.1_Chroomonas_sp_M1318 KJ676452.1_Chroomonas_sp_gCR_LOHABE01 L28811.1_Chilomonas_paramecium LC082201.1_Chroomonas_sp_Hokudai AB240962.1_Chroomonas_nordstedtii_gene_for AM051194.2_Cryptomonas_paramaecium_partial KC928314.1_Cryptomonas_paramecium_voucher_HB2012_2cp AM051195.2_Cryptomonas_paramaecium_partial AB591421.1_Chroomonas_coerulea KC928316.1_Chilomonas_insignis_voucher_HB2012_2ci LC082207.1_Chroomonas_sp_SkL01 LC082210.1_Chroomonas_sp_Docho_140919 AF508271.1_Cryptomonas_platyuris

LC082199.1_Chroomonas_sp_Ak01 1/1 AM051188.2_Cryptomonas_borealis_partial LC082202.1_Chroomonas_sp_HrL01 KF907406.1_Cryptomonas_tetrapyrenoidosa_strain_CNUCRY_127 CAMNT_0001725673_Goniomonas_sp_Strain_m89/86 LC082206.1_Chroomonas_sp_Sd07 KF907393.1_Cryptomonas_pyrenoidifera_strain_CNUCRY_69 AB591423.1_Chroomonas_nordstedtii LC082203.1_Chroomonas_sp_Od06 KF734089.1_Falcomonas_sp_CRY1V EU163587.1_Cryptomonas_pyrenoidifera_strain_WCK02 CAMNT_0016159977_Hemiselmis_tepida_CCMP443 HM561136.1_Uncultured_cryptophyte_clone_CFL161R02 KC928298.1_Cryptomonas_marssonii_voucher_HB2011_5ma LC082208.1_Hemiselmis_sp_Or06 CAMNT_0014377845_Hemiselmis_virescens_PCC157CAMNT_0014387867_Hemiselmis_rufescens_PCC563 GQ375264.1_Baffinella_frigidus_CCMP2045 AM051201.2_Cryptomonas_sp_M0741_partial AB591422.1_Chroomonas_caudata GQ375265.1_Cryptophyceae_sp_CCMP2293 AM901361.1_Cryptomonas_sp_M1634_partial CAMNT_0001225357_Hemiselmis_andersenii_CCMP644 CAMNT_0009555299_Hemiselmis_andersenii_CCMP1180 LN735351.3_Proteomonas_sp_RCC2341 EU664590.1_Uncultured_cryptophyte_clone_05M80r44AF143943.1_Falcomonas_daucoides AM901364.1_Cryptomonas_commutata_partial CAMNT_0012667531_Hemiselmis_andersenii_CCMP439

AJ007285.1_Proteomonas_sulcata FJ884690.1_Cryptophyta_sp_CR_MAL11 CAMNT_0012722549_Hemiselmis_andersenii_CCMP441 AF508275.1_Teleaulax_acuta AJ420697.1_Cryptomonas_sp_M0739 AB471786.1_Teleaulax_acuta_gene_for

HM126531.1_Teleaulax_acuta_strain_K_1486 LC082209.1_Chroomonas_sp_Ainosato_140417 HM561137.1_Uncultured_cryptophyte_clone_CFL146DB09 JQ966994.1_Teleaulax_gracilis_strain_Cr6EHU LN735347.3_Proteomonas_sp_RCC2334 0.76/- EF195738.1_Cryptophyta_sp_CR_MAL04

JQ966996.1_Teleaulax_minuta_strain_Cr8EHU 76/76 KF907401.1_Cryptomonas_sp_CNUCRY_75 AB471793.1_Teleaulax_amphioxeia FM876311.1_Plagioselmis_nannoplanctica_partial CAMNT_0000746223_Guillardia_theta_CCMP2712 AJ007280.1_Cryptomonas_sp_M420 CAMNT_0009638865_Hanusia_phi_Strain_CCMP325 KP899713.1_Teleaulax_amphioxeia_HACCP_CR01 KF907376.1_Cryptomonas_curvata_strain_CNUCRY_64 KF907383.1_Cryptomonas_obovoidea_strain_CNUCRY_76 CAMNT_0026649071_Proteomonas_sulcata_CCMP704 HM126536.1_Proteomonas_sulcata_strain_CCMP321 HM561141.1_Uncultured_cryptophyte_clone_CFL161DA02 NC_0275891_Teleaulax_amphioxeia_HACCP_CR01 KF907372.1_Cryptomonas_curvata_strain_CNUCRY_22 AM0512002_Cryptomonas_sp_CCAP_979_46_partial EU123323.1_Cryptophyta_sp_CR_MAL01 KF907375.1_Cryptomonas_curvata_strain_CNUCRY_48 HM561139.1_Uncultured_cryptophyte_clone_CFL133DB08 JQ230002.1_Cryptomonas_obovata_strain_FACHB_1301AJ007281.1_Cryptomonas_sp_M1094 KC928309.1_Cryptomonas_parapyrenoidifera_voucher_HB2012_2pa AB471791.1_Teleaulax_acutaAB164407.1_Teleaulax_sp_TUC_2 HM561140.1_Uncultured_cryptophyte_clone_CFL133DB09 CAMNT_0037767911_Baffinella_sp_CCMP2293 CAMNT_0021261077_Geminigera_cryophila_CCMP2564

CAMNT_0023425991_Rhodomonas_abbreviata_Caron_Lab_IsolateCAMNT_0013948563_Geminigera_sp_Caron_Lab_IsolateDQ419059.1_Uncultured_cryptophyte_clone_ST7_92R U53124.1_Geminigera_cryophila CAMNT_0019199713_Rhodomonas_lens_RHODO KF907404.1_Cryptomonas_sp_Yeonra43011B HQ156862.1_Uncultured_marine_cryptophyte_clone_170609_04HM561138.1_Uncultured_cryptophyte_clone_CFL146DB10 NC_0095731_Rhodomonas_salina

LN735384.3_Rhodomonas_sp_RCC2516 HM561142.1_Uncultured_cryptophyte_clone_CFL146DA06FJ169754.1_Uncultured_cryptophyte_clone_CS050L18DQ452091.1_Geminigera_cryophila AB164406.1_Plagioselmis_sp_TUC_1 LC129526.1_Cryptomonas_sp_NIES_3916_gene_for KC928317.1_Cryptomonas_ovata_voucher_HB2011_3ov HM561143.1_Uncultured_cryptophyte_clone_CFL161DA03 KC928319.1_Cryptomonas_ozolini_voucher_HB2011_1oz EU664588.1_Uncultured_cryptophyte_clone_05M82r07 KF907403.1_Cryptomonas_sp_Dumo2_100310C EF508371.1_Rhodomonas_salina_CCMP1319 EU664589.1_Uncultured_cryptophyte_clone_05M101n23EF4325221_Cryptophyta_sp_SL64_78sp_clone_A1

NC_0009261_Guillardia_thetaCAMNT_0009620827_Hanusia_phi_CCMP325 LN735465.3_Rhodomonas_sp_RCC822

AF508272.1_Plagioselmis_prolonga

AJ007287.1_Teleaulax_amphioxeia Key HQ111512.1_Geminigera_cryophila_strain_Bayly_Bay LN735408.3_Rhodomonas_sp_RCC2944 EF195736.1_Cryptophyta_sp_CR_MAL02

EF195735.1_Cryptophyta_sp_CR_MAL01 CAMNT_0013964059_Geminigera_sp_Strain_Caron_Lab_IsolateHQ111513.1_Geminigera_cryophila_strain_Ace_LakeEF195739.1_Cryptophyta_sp_CR_MAL05

CAMNT_0035595777_Rhodomonas_sp_CCMP768 LN735394.3_Rhodomonas_sp_RCC2603 Arctic species CAMNT_0021254801_Geminigera_cryophila_Strain_CCMP2564 0.02 LN735401.3_Rhodomonas_sp_RCC2626 Antarctic species HF952602.1_Rhodomonas_minuta_partial Other species LN735324.3_Rhodomonas_sp_RCC2045

LN735318.2_Rhodomonas_sp_RCC1998 LN735383.3_Rhodomonas_sp_RCC2513

EU664587.1_Uncultured_cryptophyte_clone_05M82n18 x/y MrBayes support: 50%/ 80% trim a/b RaxML support: 50%/ 80% trim

KC928320.1_Plagioselmis_nannoplanctica_voucher_HB2011_4pn

0.01 (i) 18S tree

CAMNT_0029534911_Aureococcus_anophagefferens_CCMP1850 LC189147.1_Pelagomonas_calceolata KT861111.1_Pelagophyceae_sp_RCC1024 MF927475.1_Pelagophyceae_sp_CCMP3390 KT861109.1_Pelagomonas_calceolata_strain_RCC969 U40928.1_Coccoid_pelagophyte_CCMP1145 U14389.1_Pelagomonas_calceolata LC012594.1_Pelagomonas_calceolata LC189153.1_Pelagomonas_calceolata CAMNT_0045551779_Pelagomonas_calceolata_CCMP1756 U40927.1_Coccoid_pelagophyte_CCMP1395 U14386.1_Pelagococcus_subviridis CAMNT_0034332155_Pelagococcus_subviridis_CCMP1429 MF927477.1_Chrysoreinhardia_giraudii_strain_CCMP3201 KF422616.1_Sarcinochrysis_sp_CCMP770 MF927487.1_Chrysoreinhardia_giraudii_strain_BEA_0313B MF927474.1_Chrysoreinhardia_muelleri_strain_Chryso_1 HQ710576.1_Sarcinochrysis_sp_HSY_2011_voucher_A_11551 AB183669.1_Chrysocystis_sp_MBIC11134 KF422612.1_Chrysocystis_fragilis_culture_collection_CCMP MF927482.1_Sungminbooa_caribensis_strain_CCMP292 HQ710577.1_Sarcinochrysis_sp_HSY_2011_voucher_A_11864 MF927485.1_Aureoumbra_geitleri_strain_BEA_0312B U40258.1_Aureoumbra_lagunensis HQ710574.1_Aureoumbra_lagunensis_culture_CCMP KF899841.1_Pelagophyceae_sp_CCMP2135 MF927481.1_Sargassococcus_simulans_strain_CCMP1996 CAMNT_0006835335_Chrysoreinhardia_sp_Strain_CCMP3193 U40926.1_Coccoid_pelagophyte_CCMP1410 MF927480.1_Pelagospilus_aureus_strain_CCMP1410 KP178600.1_Andersenia_australica_voucher_CS_1115 MF927483.1_Arachnochrysis_demoulinii_strain_CCMP2351 MF927486.1_Sarcinochrysis_marina_strain_BEA_0109B EU247837.1_Novel_pelagophyte_CCMP2097 Key JF794050.1_Pelagophyceae_sp_RCC2040 KT861000.1_Pelagophyceae_sp_RCC2511 1/0.99 KT860994.1_Pelagophyceae_sp_RCC2494 Arctic species -/80 1/1 HQ710571.1_Ankylochrysis_lutea_voucher_RCC_286 Other species -/74 FJ973363.1_Ankylochrysis_lutea_strain_RCC_286 AM850221.1_Pseudochattonella_verruculosa CAMNT_0024818843_Florenciella_sp_Strain_RCC1587 x/ y: MrBayes PP (50% /80% trim) CAMNT_0024764567_Florenciella_parvula_Strain_RCC1693 a/ b: RAxML best-scoring tree (50%/ 80%) CAMNT_0007589219_Florenciella_parvula_Strain_CCMP2471 HQ646562.1_Dictyocha_octonaria_strain_NIWA1026 CAMNT_0028431175_Dictyocha_speculum_Strain_CCMP1381 CAMNT_0006949763_Rhizochromulina_marina_cf_Strain_CCMP1243 CAMNT_0035351951_Pseudopedinella_elastica_CCMP716 CAMNT_0037599551_Undescribed_sp_CCMP2098

0.03 (ii) 16S tree CAMNT_0028356489_Chrysoreinhardia_sp_CCMP2950 GQ231542.1_Aureoumbra_lagunensis_CCMP_1507 CAMNT_0029574277_Aureoumbra_lagunensis_CCMP1510 CAMNT_0044386967_unid_sp_CCMP2135 CAMNT_0006833137_Chrysoreinhardia_sp_CCMP3193 LN735372.3_Ankylochrysis_sp1_RCC2493 LN735374.3_Ankylochrysis_sp1_RCC2496 LN735373.3_Ankylochrysis_sp1_RCC2494 1/1 LN735371.3_Ankylochrysis_sp1_RCC2491 96/96 LN735319.2_Ankylochrysis_sp1_RCC2005 0.90/0.93 CAMNT_0037538183_Novel_pelagophyte_CCMP2097 -/- LN735511.3_Pelagomonas_sp_RCC986 LN735206.2_Pelagomonas_sp_RCC1024 LN735200.2_Pelagomonas_sp_RCC1003 NC_0128981_Aureococcus_anophagefferens LN735490.3_Pelagomonas_sp_RCC919 CAMNT_0034340035_Pelagococcus_subviridis_CCMP1429 KT956315.1_Uncultured_Pelagomonas_clone_ST4_40 KT956288.1_Uncultured_Pelagomonas_clone_ST4_32 LN735491.3_Pelagomonas_sp_RCC924 CAMNT_0045571737_Pelagomonas_calceolata_CCMP1756 CAMNT_0007255953_Pelagomonas_calceolata_RCC969 LN735512.3_Pelagomonas_sp_RCC987 LN735502.3_Pelagomonas_calceolata CAMNT_0028428879_Dictyocha_speculum_CCMP1381 LN735339.3_Pedinella_sp_RCC2286 CAMNT_0037565363_Novel_dictyochophyte_CCMP2098 CAMNT_0035379279_Pseudopedinella_elastica_CCMP716 LN735338.3_Helicopedinella_sp_RCC2284 LN735343.3_Helicopedinella_sp_RCC2303 LN735277.2_Florenciella_parvula MK518352.1_Florenciella_parvula_voucher_CCMP2471 CAMNT_0024736953_Florenciella_parvula_RCC1693 CAMNT_0024819141_Florenciella_sp_RCC1587 CAMNT_0053317975_Florenciella_sp_RCC1007

0.04 (i) 18S tree AM491022.2_Chrysochromulina_spinifera_partial

HM561162.1_Uncultured_haptophyte_clone_CFL133DA03

EU682596.1_Uncultured_haptophyte_clone_05M100r16AF107089.1_Unidentified_prymnesiophyte_clone_OLI51059

AM491006.1_Prymensium_sp_ALGO_HAPPM_partial AM491002.2_Prymensium_sp_ALGO_HAPPM_partial

KJ540196.1_Chrysochromulina_sp_CCMP291 HQ156821.1_Uncultured_marine_haptophyte_clone_080609_15CAMNT_0015900327_Chrysochromulina_brevifilum_Strain_UTEX_LB_985

LT222484.1_Chrysochromulina_sp_Hp34EHU_partial AM491008.2_Prymnesium_calathiferum_partial AB199882.1_Chrysochromulina_sp_MBIC10513_gene_forAM491020.1_Chrysochromulina_sp_LKM_2007.1_partial

AM491007.2_Prymnesium_annuliferum_partial

KT861300.1_Chrysochromulina_sp_RCC400 AM491005.2_Prymnesium_faveolatum_partial

AJ246277.1_Chrysochromulina_throndsenii HQ156869.1_Uncultured_marine_haptophyte_clone_170609_17 AB180202.3_Chrysochromulina_andersonii_genes_for

FN599060.1_Chrysochromulina_strobilus_partial AJ246278.1_Chrysochromulina_acantha LT560338.1_Chrysochromulina_rotalis_partial AM491018.1_Chrysochromulina_cymbium_partial AF107080.1_Unidentified_prymnesiophyte_clone_OLI16029AM491017.2_Chrysochromulina_leadbeateri_partial AJ246273.1_Chrysochromulina_campanulifera KT878670.1_Chrysochromulina_sp_RCC390 AF166376.1_Prymnesiophyte_symbiont_3

AF166378.1_Prymnesiophyte_symbiont_4 AF166377.1_Prymnesiophyte_symbiont_1

JF261100.1_Platychrysis_sp_BG_2011

AM491021.2_Chrysochromulina_simplex_partial

HM561166.1_Uncultured_haptophyte_clone_CFL133R09 AB183265.1_Hyalolithus_neolepis_gene_for HM561167.1_Uncultured_haptophyte_clone_CFL133R10AM490994.1_Chrysochromulina_parkeae_partial FR865770.1_Platychrysis_pigra_genomic_DNA_containing

AM491028.2_Prymnesium_simplex_partial AJ246274.1_Chrysochromulina_scutellum AM491027.2_Prymnesium_pienaarii_partial AB183611.1_Platychrysis_sp_MBIC10528_gene_for

AM491000.2_Prymnesium_sp_ALGO_HAP_pt_partial AM490995.2_Haptolina_brevifilum_partial AM491001.2_Prymnesium_zebrinum_partial L34670.1_Prymnesium_patelliferumL34671.1_Prymnesium_patelliferumCAMNT_0035112487_Prymnesium_parvum_Texoma1FR677016.1_Prymnesium_sp_BO18 HM561164.1_Uncultured_haptophyte_clone_CFL133DB11 AJ246268.2_Prymnesium_nemamethecum

HM561165.1_Uncultured_haptophyte_clone_CFL161DB05 AJ004866.1_Prymnesium_polylepisCAMNT_0038245415_Chrysochromulina_polylepis_CCMP1757 AM491009.2_Prymnesium_cf_polylepis_partial AM491010.2_Prymnesium_minor_partial AJ004868.1_Prymnesium_aff_polylepis HM561163.1_Uncultured_haptophyte_clone_CFL133DB10 X77475.1_Ppouchetii_Hariot_LagerheimAJ278036.1_Phaeocystis_pouchetii

AM491029.2_Prymnesium_chiton_partial AM779755.1_Prymnesium_palpebrale FN551249.1_Chrysochromulina_sp_170_E4_partial AJ246271.1_Prymnesium_kappa

AM491012.1_Haptolina_brevifila_partial KT861294.1_Phaeocystis_sp_RCC1617 AM491011.1_Haptolina_cf_herdlensis_partialAM491016.2_Pseudohaptolina_arctica_partialJN934681.1_Imantonia_sp_RCC2298 CAMNT_0006778857_Phaeocystis_Sp_Strain_CCMP2710 AJ246272.1_Haptolina_hirtaAM491030.2_Haptolina_ericina_partial KT861295.1_Phaeocystis_sp_RCC1619 AM491013.2_Haptolina_fragaria_partialJF812342.1_Haptolina_sp_RCC2300KC888128.1_Dicrateria_inornata_strain_PLY564 KT861316.1_Imantonia_sp_RCC3050 AM491015.1_cf_Imantonia_sp_CCMP_1404_partial JX660986.1_Phaeocystis_globosa_culture_collection_RCC AB183606.1_Imantonia_sp_MBIC10500_gene_for EU077556.1_Phaeocystis_globosa AB183605.1_Imantonia_sp_MBIC10497_gene_for DQ075202.1_Phaeocystis_sp_Hongkong2 EU924188.1_Isochrysis_sp_0318

KP144246.1_Phaeocystis_antarctica_strain_CCMP1374 AB636317.1_Tergestiella_adriatica_gene_forAB158370.1_Chrysoculter_rhomboideus_gene_forAY303354.1_Uncultured_haptophyte_DGGE_gel_band_4 AY303355.1_Uncultured_haptophyte_DGGE_gel_band_5AY303353.1_Uncultured_haptophyte_DGGE_gel_band_3 CAMNT_0043861829_Phaeocystis_antarctica_Strain_CCMP1374KP144253.1_Phaeocystis_antarctica_strain_CCMP1871 CAMNT_0013893081_Phaeocystis_antarctica_Strain_Caron_Lab_Isolate AB983345.1_Gladiolithus_sp_KH_2014_gene_for CAMNT_0007356467_Scyphosphaera_apsteinii_Strain_RCC1455 AM490983.2_Helicosphaera_carteri_partial AM490986.2_Coronosphaera_mediterranea_partialDQ0798591_Isochrysis_sp_CCAP_927_14 CAMNT_0032313801_Isochrysis_sp_CCMP1324 EF432535.1_Haptophyceae_sp_W6_4_clone_A1 AM490987.2_Syracosphaera_pulchra_partialHQ877920.1_Isochrysis_sp_KMMCC_H_22 KY399776.1_Isochrysis_sp DQ075203.1_Isochrysis_sp_zhangjiangensis KF422607.1_Phaeocystis_rex_culture_collection_CCMP EF432545.1_Haptophyceae_sp_W5_1 JN938582.1_Isochrysis_sp_LL_2012_strain_IOAC724S JX660992.1_Phaeocystis_cordata_culture_collection_RCC JF489948.1_Isochrysis_sp_MA_2012_isolate_IsochrysissppI DQ071573.1_Isochrysis_sp_8701 DQ071572.1_Isochrysis_sp_3011 JX660990.1_Phaeocystis_sp_JD_2012_culture_collection_RCCLC189148.1_Phaeocystis_jahnii_gene_for KC888102.1_Chrysotila_sp.1_EMB_2013_strain_PLY510A AM491023.1_Phaeocystis_sp_PLY559_partial KC888099.1_Chrysotila_lamellosa_strain_PLY408 LC322316.1_Isochrysis_sp_Dm.2_gene_for AF107091.1_Unidentified_prymnesiophyte_clone_OLI51080 LC322317.1_Isochrysis_sp_Dm.3_gene_for LC322314.1_Isochrysis_sp_Sc.1_gene_for LC322315.1_Isochrysis_sp_Sc.2_gene_for AM490999.2_Pseudoisochrysis_paradoxa_partial HM149540.1_Isochrysis_galbana_strain_CCMP1323 AY303356.1_Uncultured_haptophyte_DGGE_gel_band_6 AM490996.2_Isochrysis_litoralis_partial AM490997.2_Dicrateria_sp_ALGO_HAP49_partial AF106053.1_Pavlova_lutheri KC888117.1_Isochrysis_sp.1_EMB_2013_strain_PLY401b KC888115.1_Isochrysis_sp.1_EMB_2013_strain_RCC1207 JF489960.1_Pavlova_lutheri_isolate_PlutheriII KC888114.1_Isochrysis_sp.1_EMB_2013_strain_AC49 AF106051.1_Pavlova_gyrans_strain_Pav_1 KC888116.1_Isochrysis_sp.1_EMB_2013_strain_RCC2477 U40922.1_Pavlova_gyrans_nuclear AY303352.1_Uncultured_haptophyte_DGGE_gel_band_2 AY303351.1_Uncultured_haptophyte_DGGE_gel_band_1 U40924.1_Coccoid_haptophyte_CCMP625_nuclearLC322313.1_Isochrysis_sp_Sh.2_gene_for AB183665.1_Gephyrocapsa_oceanica_gene_forLC322312.1_Isochrysis_sp_Sh.1_gene_for FR8657731_Pavlova_sp_CCAP_940.2_genomic_DNA_containing KC404141.1_Emiliania_huxleyi_isolate_ESP7414 FR865774.1_Rebecca_salina_genomic_DNA_containing KP282839.1_Gephyrocapsa_muellerae_strain_RCC3862 HQ877912.1_Pavlova_gyrans_strain_KMMCC_H_12 CAMNT_0032206825_Isochrysis_sp_CCMP1244 JF7142471_Pavlova_pinguis_strain_CCAP940_2 CAMNT_0030755173_Emiliania_huxleyi_379_ 1/1 CAMNT_0030887851_Emiliania_huxleyi_PLYM219 AF106047.1_Pavlova_pinguis_strain_Pav_6JF714233.1_Pavlova_sp_AC19 CAMNT_0030672149_Emiliania_huxleyi_374 CAMNT_0030825969_Emiliania_huxleyi_CCMP370 CAMNT_0034296067_Pavlova_sp_CCMP459 69/69 AM490985.2_Algirosphaera_robusta_partial CAMNT_0053438135_Pavlova_gyrans_Strain_CCMP608 1/1 KX056533.1_Reticulofenestra_parvula_isolate_RCC4033 HQ877915.1_Pavlova_sp_CCMP_1390 KX056532.1_Gephyrocapsa_ericsonii_isolate_RCC4032 53/51 AB183627.1_Pavlova_sp_MBIC10665_gene_for AJ246262.1_Cruciplaccolithus_neohelis JF714232.1_Pavlova_sp_AC250 AB183588.1_Pavlova_sp_MBIC10094_gene_for AB183625.1_Pavlova_sp_MBIC10652_gene_for AJ544119.1_Umbilicosphaera_foliosa_partial JF714234.1_Pavlova_sp_AC248 AM490993.2_Umbilicosphaera_hulburtiana_partial JF714230.1_Pavlova_sp_AC251 AJ544118.1_Umbilicosphaera_sibogae_partial AJ243369.1_Pavlova_sp_CCMP1416 AJ544116.1_Calcidiscus_leptoporus_partial AM491026.2_Oolithotus_fragilis_partial FR865767.1_Ochrosphaera_neapolitana_genomic_DNA_containingAJ544115.1_Calcidiscus_quadriperforatus_partial AM490992.2_Calyptrosphaera_sp_LKM_2007.1_partial AM490979.2_Jomonlithus_littoralis_partialAJ246261.1_Coccolithus_pelagicus AF106058.1_Pavlova_pinguis_strain_IIY089 AB183638.1_Ochrosphaera_sp_MBIC10788_gene_for AB183615.1_Ochrosphaera_sp_MBIC10548_gene_forAJ544117.1_Coccolithus_braarudii_partial JF714229.1_Pavlova_sp_AC33 AB058347.1_Isochrysis_sp_MBIC10464_gene_forAM491024.2_Calyptrosphaera_radiata_partial AJ515249.1_Pavlova_pseudogranifera AB183604.1_Ochrosphaera_sp_MBIC10476_gene_for AB183598.1_Pavlova_sp_MBIC10455_gene_for AM490980.2_Ochrosphaera_verrucosa_partial AF106057.1_Pavlova_pinguis_strain_KD6B KT861240.1_Ochrosphaera_sp_RCC2698 AM490990.2_Calyptrosphaera_sphaeroidea_partial AB183603.1_Isochrysis_sp_MBIC10475_gene_for DQ075201.1_Pavlova_viridis

JF714231.1_Pavlova_granifera_strain_AC539 AF106049.1_Pavlova_sp_J013 AB183617.1_Isochrysis_sp_MBIC10557_gene_for L34669.1_Pavlova_salina AM490982.2_Hymenomonas_coronata_partial AM490991.1_Helladosphaera_sp_LKM_2007.1_partial HQ877919.1_Pavlova_sp_KMMCC_H_21HQ877916.1_Pavlova_sp_CCMP_620

AM490981.2_Hymenomonas_globosa_partial

JF714245.1_Rebecca_sp_AC537

EU247835.1_Pavlovales_sp_CCMP2436 AF106056.1_Diacronema_vlkianumJF714240.1_Diacronema_sp_AC54

JF714227.1_Exanthemachrysis_sp_AC35

JF714228.1_Exanthemachrysis_sp_AC245 AJ515248.1_Pavlova_virescens HG970975.1_Haptophyceae_sp_EE_2014_partial

JF714225.1_Exanthemachrysis_sp_AC246 DQ207406.1_Corcontochrysis_noctivagaJF714244.1_Rebecca_salina_strain_PLY465 JF714239.1_Diacronema_sp_AC247JF714243.1_Pavlova_ennorea_strain_AC253

AB183595.1_Pavlova_sp_MBIC10442_gene_for AM490977.2_Pleurochrysis_placolithoides_partial

AB183616.1_Pleurochrysis_sp_MBIC10549_gene_for

EF208116.1_Pleurochrysis_sp_NMBjih026 AJ544121.1_Pleurochrysis_dentata_partial AM490975.2_Pleurochrysis_sp_ALGO_Langue_du_chat_partial AM490978.2_Pleurochrysis_scherffelii_partialAJ544120.1_Pleurochrysis_carterae_partial JF714237.1_Pavlova_sp_AC248 AJ246264.1_Pleurochrysis_elongata AJ246275.1_unclassified_coccolithophorid_CCMP_300AJ246263.1_Pleurochrysis_carterae HQ877909.1_Pavlova_sp_KMMCC_H_9 AM490974.2_Pleurochrysis_roscoffensis_partial AM490973.2_Pleurochrysis_pseudoroscoffensis_partial HQ877908.1_Pavlova_sp_KMMCC_H_8 AM490972.2_Pleurochrysis_gayraliae_partial JF714243.1_Pavlova_noctivaga_strain_ACOI449

KU561125.1_Rebecca_salina_isolate_DHmm3W3

CAMNT_0053342933_Pavlova_lutheri_Strain_RCC1537

CAMNT_0007459915_Chrysoculter_rhomboideus_Strain_RCC1486 CAMNT_0053371527_Exanthemachrysis_gayraliae_Strain_RCC1523 Key

FR8657661_Monochrysis_sp_CCAP_931.2_genomic_DNA_containing

EU682597.1_Uncultured_haptophyte_clone_05M100n14 Arctic species Antarctic species Other species

AJ246265.1_Pleurochrysis_sp_CCMP_875 x/y MrBayes consensus support: 50%/ 80% trim

CAMNT_0034582983_Pleurochrysis_carterae_CCMP645 AB183596.1_Pleurochrysis_sp_MBIC10443_gene_for a/b RaxML best-scoring tree: 50%/ 80% trim

(ii) 16S tree 0.02 CAMNT_0007304963_Scyphosphaera_apsteinii_RCC1455 CAMNT_0030884295_Emiliania_huxleyi_PLYM219

CAMNT_0030721753_Emiliania_huxleyi_379

AB847984.2_Braarudosphaera_bigelowii_gene_for

LN735257.2_Syracosphaera_pulchra

LN735414.3_Ochrosphaera_sp_RCC2970 LN735236.2_Helicosphaera_carteri

LN735418.3_Ochrosphaera_sp_RCC2976

LN735417.3_Ochrosphaera_sp_RCC2974

LN735238.2_Ochrosphaera_neapolitana LN735416.2_Ochrosphaera_sp_RCC2973

LN735415.3_Ochrosphaera_sp_RCC2972

LN735239.2_Ochrosphaera_sp_RCC1366

LN735409.3_Ochrosphaera_sp_RCC2959

JN022705.1_Emiliania_huxleyi_culture_collection_CCMP CAMNT_0031505495_Gephyrocapsa_oceanica_RCC1303 AY741371.1_Emiliania_huxleyi_CCMP_373 LN735245.2_Pleurochrysis_sp_RCC1392 CAMNT_0032201019_Isochrysis_sp_CCMP1244 CAMNT_0030707681_Emiliania_huxleyi_374 CAMNT_0030834423_Emiliania_huxleyi_CCMP370CAMNT_0038133297_Isochrysis_galbana_CCMP1323 CAMNT_0034597763_Pleurochrysis_carterae_CCMP645 LN735369.3_Isochrysis_nuda LN735246.2_Pleurochrysis_sp_RCC1393 CAMNT_0032313189_Isochrysis_sp_CCMP1324 MF795089.2_Tisochrysis_lutea NC_0402911_Tisochrysis_lutea

LN735368.3_Pleurochrysis_sp_RCC2476

LN735419.3_Cruciplacolithus_sp_RCC2977

CAMNT_0037929913_Pavlovales_CCMP2436 LN735420.3_Cruciplacolithus_sp_RCC2978 CAMNT_0053405297_Exanthemachrysis_gayraliae_RCC1523CAMNT_0007460697_Chrysoculter_rhomboideus_RCC1486CAMNT_0053369891_Pavlova_lutheri_RCC1537 1/1 NC_0203711_Pavlova_lutheri 100/75 KC573041.1_Pavlova_lutheri LN735346.3_Calcidiscus_sp_RCC2325 LN735387.3_Pavlova_sp_RCC2541 0.74/0.71 AF172715.1_Pavlova_gyrans LN735220.2_Calcidiscus_leptoporus 78/ 79 CAMNT_0053438957_Pavlova_gyrans_CCMP608 CAMNT_0034265807_Pavlova_sp_CCMP459 CAMNT_0007378841_Calcidiscus_leptoporus_RCC1130 LN735390.3_Pavlova_sp_RCC2551 LN735389.3_Pavlova_sp_RCC2550 LN735221.2_Calcidiscus_quadriperforatus LN735244.2_Prymnesium_pigrum LN735242.2_Prymnesium_simplex LN735260.2_Umbilicosphaera_hulburtiana LN735243.2_Prymnesium_sp_RCC1389 LN735247.2_Prymnesium_zebrinum LN735227.2_Chrysochromulina_sp_RCC1191 LN735259.2_Umbilicosphaera_sibogae LN735250.2_Prymnesium_parvum CAMNT_0035192417_Prymnesium_parvum_Texoma1 LN735240.2_Oolithotus_fragilis LN735254.2_Prymnesium_neolepis AF172719.1_Chrysochromulina_polylepis CAMNT_0038248125_Chrysochromulina_polylepis_CCMP1757 LN735253.2_Prymnesium_calathiferum LN735226.2_Prymnesium_kappa LN735231.2_Coccolithus_braarudii CAMNT_0023273127_Chrysochromulina_ericina_CCMP281

CAMNT_0025556259_Coccolithus_pelagicus_ssp_braarudi_PLY182g LN735326.3_Haptolina_ericina LN735342.3_Haptolina_hirta LN735222.2_Chrysochromulina_sp_RCC1184

LN735327.3_Haptolina_fragaria

LN735445.3_Imantonia_rotunda LN735224.2_Chrysochromulina_camella

LK391824.1_Chrysochromulina_elegans CAMNT_0015890455_Chrysochromulina_brevifilum_UTEX_LB_985 KT956292.1_Uncultured_haptophyte_clone_ST4_30

NC_0369371_Chrysochromulina_parva_2 LN735496.3_Phaeocystis_jahnii

LK391822.1_Phaeocystis_cordata

KT956290.1_Uncultured_Phaeocystis_clone_ST4_8 KT956298.1_Uncultured_Phaeocystis_clone_ST4_13

LN735513.3_Phaeocystis_sp_RCC994

KJ201907.2_Chrysochromulina_sp_CCMP291_2

LN735432.3_Chrysochromulina_sp_RCC574

LN735331.3_Chrysochromulina_throndseniiLK391825.1_Chrysochromulina_apheles CAMNT_0003281755_Chrysochromulina_rotalis_UIO044

NC_0216371_Phaeocystis_globosa_Pg_G_A_2

KT956289.1_Uncultured_Phaeocystis_clone_ST4_10

DQ442654.1_Phaeocystis_antarctica_isolate_W6_4

DQ442653.1_Phaeocystis_antarctica_isolate_RS_24 JN117275.2_Phaeocystis_antarctica_CCMP1374_2

CAMNT_0043826573_Phaeocystis_antarctica_CCMP1374

DQ442652.1_Phaeocystis_antarctica_isolate_W5_1

CAMNT_0013831151_Phaeocystis_antarctica_Caron_Lab_Isolate 0.05

CAMNT_0006738711_Phaeocystis_Sp_CCMP2710 (i) 18S tree

EU787424.1_Spumella_sp_9_20_C4 EU787421.1_Spumella_sp_9_2_A2

EU787423.1_Spumella_sp_9_14_D1

EU787422.1_Spumella_sp_9_7_F1 FR865763.1_Chromulina_ochromonoides_genomic_DNA_containing

AY651085.1_Spumella_like_flagellate_JBMS12

EF043285.1_Spumella_like_flagellate_JBMS11

MF348301.1_Uncultured_Chrysophyceae_clone_Mar_3

AY651084.1_Spumella_like_flagellate_JBM19 EF165138.1_Ochromonas_marina_strain_AC22 MK153237.1_Uroglena_sp_isolate_U29_5 AY651079.1_Spumella_like_flagellate_JBAS36 MK153236.1_Uroglena_volvox_isolate_U26_3 MK153238.1_Uroglena_sp_isolate_UK_37EF165139.1_Ochromonas_sp_CCMP1149

U42381.1_Ochromonas_CCMP584 EF165137.1_Ochromonas_sp_CCMP1147EF165125.1_Ochromonas_sp_AC514 EF165135.1_Ochromonas_sp_CCMP592 KF651119.1_Spumella_sp_OF_40

JN934680.1_Dinobryon_faculiferum_strain_RCC2293 EF027354.1_Spumella_sp_GOT220 AJ236861.1_Spumella_danica AY520447.1_Ochromonas_sp_TCS_2004DQ388539.1_Spumella_like_flagellate_JBC20 DQ388540.1_Spumella_like_flagellate_JBC21 JF794055.1_Chrysophyceae_sp_RCC2290 EF165108.1_Ochromonas_danica_strain_CCMP588 KX100616.1_Epipyxis_sp_PR26KG JQ281514.1_Ochromonas_danica_strain_SAG9337 EF165124.1_Ochromonas_sp_aestuarii

EU024993.1_Dinobryon_pediforme_strain_LO128_17U42382.1_Ochromonas_CCMP1278 EF165123.1_Ochromonas_cf_sphaerocystis_strain_CCMP2061 KX431475.1_Spumella_sp_strain_IOW111 EU024992.1_Dinobryon_pediforme_strain_LO128_16 AY651078.1_Spumella_like_flagellate_JBC22EF165143.1_Ochromonas_perlata_strain_CCMP2732 CAMNT_0042136231_Chromulina_nebulosa_Strain_UTEXLB2642 EF165140.1_Dinobryon_cylindricum_strain_CCMP2766

KX100629.1_Dinobryon_sp_strain_FU24KBO EF165131.1_Uroglena_americana_strain_CCMP2769 JF730878.1_Kephyrion_sp_CCMP3057 MK153241.1_Uroglenopsis_sp_isolate_U19 MK153242.1_Uroglenopsis_americana_isolate_UK_4 EF165141.1_Dinobryon_cf_sociale_strain_UTCC392 EF165142.1_Ochromonas_sp_CCMP1393KX100615.1_Chrysophyceae_sp_strain_WA34KABMK153244.1_Uroglenopsis_turfosa_isolate_UK_81 CAMNT_0038036591_Ochromonas_sp_CCMP2298

JQ315654.1_Spumella_sp_KMMCC_242 AJ236859.1_Spumella_elongata MK153239.1_Uroglenopsis_sp_isolate_UJ_6MK153243.1_Uroglenopsis_turfosa_isolate_UN_28 AY651083.1_Pedospumella_encystans_voucher_B_40_0040671 AY651082.1_Spumella_like_flagellate_JBCS24 EF165145.1_Chrysocapsa_paludosa_strain_CCMP380 LC000675.1_Spumella_sp_TGPH8_gene_for AY651081.1_Spumella_like_flagellate_JBCS23 DQ388558.1_Spumella_like_flagellate_1006 MK153240.1_Uroglenopsis_sp_isolate_UK_25 EU005402.1_Dinobryon_pediforme EF165130.1_Chrysocapsa_sp_UTCC280 FR865768.1_Ochromonas_villosa_genomic_DNA_containing DQ388542.1_Spumella_like_flagellate_JBNA46 EF165104.1_Chrysonebula_flava_strain_CCMP2765 AY651080.1_Spumella_like_flagellate_JBC13 EF165105.1_Chrysocapsa_vernalis_strain_CCMP278 KY464901.1_Chrysophyceae_sp_strain_1_4_C4 KY575274.1_Ochromonas_triangulata_strain_A14_651 KT860964.1_Ochromonas_distigma_strain_RCC21 KU900228.1_Ochromonas_sp_UTEX_LB_2575 AY651071.1_Spumella_like_flagellate_JBAF35 CAMNT_0014054771_Ochromonas_sp_Strain_BG_1EF165115.1_Ochromonas_sp_ACOI_1258 EF165103.1_Chromulina_sp_SAG1797 EF165144.1_Ochromonas_sp_CCMP2740 AY651077.1_Spumella_like_flagellate_JBAF33 1/0.95 EF165113.1_Ochromonas_cf_gloeopara_strain_CCMP2060 EF165102.1_Chrysamoeba_tenera_strain_UTCC273 95/92 EU787418.1_Spumella_sp_9_12_B3 MK153247.1_Urostipulosphaera_notabilis_isolate_U12_1 KX100589.1_Chrysophyceae_sp_strain_OE32KL KX100618.1_Chrysophyceae_sp_strain_WA32KAZ AY651093.1_Spumella_like_flagellate_JBC27 KX100619.1_Chrysophyceae_sp_strain_WA32KA KX431464.1_Chrysophyceae_sp_strain_IOW65 MK153248.1_Urostipulosphaera_sp_isolate_U10_6 MK153246.1_Urostipulosphaera_sp_isolate_U5_5 MK153249.1_Urostipulosphaera_sp_isolate_UP_34 MG674909.1_Uncultured_Chrysolepidomonas_clone_Esp10 MK153245.1_Urostipulosphaera_sp_isolate_U7_1EF165126.1_Ochromonas_sp_CCMP2761 EF165132.1_Uroglena_sp_CCMP2768FN429125.1_Ochromonas_sp_99X4_partial MG674911.1_Uncultured_Chrysolepidomonas_clone_Esp17 LC000674.1_Ochromonas_sp_TGPH2_gene_for EF165110.1_Ochromonas_sp_CCMP2767 EF165111.1_Ochromonas_vasocystis_strain_CCMP2741 MG674910.1_Uncultured_Chrysophyceae_clone_Esp16 EU787413.1_Spumella_sp_1_8_A1 EF165109.1_Ochromonas_sp_SAG93310 EU787416.1_Spumella_sp_1_18_F1 MG674906.1_Uncultured_Chrysophyceae_clone_Boeck4EF165134.1_Chrysophyceae_sp_CCCM41 EU787419.1_Spumella_sp_9_14_C1 EU247834.1_Chrysophyceae_sp_CCMP2296 EU787414.1_Spumella_sp_1_13_F1 EU787417.1_Spumella_sp_9_8_D3 EU787420.1_Spumella_sp_9_1_D1 EU787415.1_Spumella_sp_1_13_F4 KX100620.1_Poteriospumella_sp_strain_D_7_A2 AY651097.1_Spumella_like_flagellate_JBC07 AY651074.1_Poteriospumella_lacustris_voucher_B_40_0040673 AY651076.1_Spumella_like_flagellate_JBAF32 AY651072.1_Spumella_like_flagellate_JBC31 DQ388538.1_Spumella_like_flagellate_JBAS38 LC000679.1_Spumella_sp_TGKK2_gene_for Freshwater_Arctic_FM955256.1_Hydrurus_foetidus_partialHE820741.1_Uncultured_Hydrurus_partial LC000676.1_Spumella_sp_TGKH6_gene_for MG674907.1_Uncultured_Hydrurus_clone_Boeck27 CAMNT_0042910539_Pinguiococcus_pyrenoidosus_Strain_CCMP2078CAMNT_0006827079_Phaeomonas_parva_Strain_CCMP2877 AY651073.1_Spumella_like_flagellate_JBC30 AM490833.1_Phaeobotrys_solitaria_partial MG674904.1_Uncultured_Hydrurus_clone_Boeck1 JQ967332.1_Spumella_sp_CH3AY651089.1_Spumella_like_flagellate_JBM28 MG674912.1_Uncultured_Hydrurus_clone_Esp21 AY651075.1_Spumella_like_flagellate_JBNZ41 MG674908.1_Uncultured_Hydrurus_clone_Boeck31 AY651088.1_Spumella_like_flagellate_JBNZ39 AY651087.1_Spumella_like_flagellate_JBM09AB585964.1_Spumella_sp_TGS1_gene_for AY651086.1_Spumella_like_flagellate_JBL14

CAMNT_0007030041_Ochromonas_sp_Strain_CCMP1899 AB425951.1_Spumella_sp_Mbc_3C_gene_forAB585967.1_Spumella_sp_TGS4_gene_forDQ388541.1_Spumella_like_flagellate_JBNA45 MG674914.1_Uncultured_Ochromonas_clone_Esp29EF432525.1_Chrysophyceae_sp_I76_clone_A1 MG674905.1_Uncultured_Hydrurus_clone_Boeck2 JQ967317.1_Paraphysomonas_sp_29_JMS_2012AJ236860.1_Spumella_obliqua EU787425.1_Spumella_sp_9_10_C1

KX100594.1_Chrysophyceae_sp_strain_PR34KL

AY651092.1_Spumella_like_flagellate_JBM18 FJ971855.1_Chrysophyceae_sp_EK_2010a

AY651098.1_Spumella_like_flagellate_JBM08 FJ971854.1_Chrysophyceae_sp_EK_2010a_strain_JYME2JX465727.1_Chrysophyceae_sp_CCMP381 EF165121.1_Chrysosaccus_sp_CCMP368

AF044845.1_Chrysosaccus_sp_CCMP295EF165120.1_Chrysosaccus_sp_CCMP1156

AF109322.1_Paraphysomonas_bandaiensis EF185317.1_Chrysophyceae_sp_CCMP261 KX100591.1_Paraphysomonas_sp_strain_JBAF49

JQ967322.1_Paraphysomonas_sp_12_JMS_2012 Key AF109325.1_Paraphysomonas_vestita

AB474963.1_Chromophyton_vischeri_gene_for KX100590.1_Paraphysomonas_sp_strain_JBAU44

MG674913.1_Uncultured_Ochromonas_clone_Esp24 JQ967292.1_Paraphysomonas_sp_7_JMS_2012 AY651094.1_Spumella_like_flagellate_JBAS37 Arctic species EF165122.1_Chrysophyceae_sp_CCMP349 AB616676.1_Spumella_sp_TGS6_gene_for Antarctic species KX100592.1_Paraphysomonas_sp_strain_JBAFS48 FR865769.1_Ochromonas_tuberculata_genomic_DNA_containingJQ967328.1_Paraphysomonas_sp_CCL3C EF165107.1_Chromophyton_cf_rosanoffii_strain_CCMP2753JQ967291.1_Paraphysomonas_butcheri_isolate_MD03 KX100593.1_Paraphysomonas_sp_strain_JBAFS47 EF165106.1_Chromophyton_cf_rosanoffii_strain_CCMP2751 AJ236863.1_Paraphysomonas_sp All other species JQ967327.1_Paraphysomonas_sp_WA20KP JQ967296.1_Paraphysomonas_sp_30_JMS_2012 AF174376.1_Paraphysomonas_foraminifera JQ967331.1_Paraphysomonas_sp_21_JMS_2012JQ967330.1_Paraphysomonas_sp_22_JMS_2012 AY651096.1_Spumella_like_flagellate_JBM06 AY651090.1_Spumella_like_flagellate_JBC29JQ967329.1_Paraphysomonas_sp_34_JMS_2012 JQ967297.1_Paraphysomonas_sp_EP4 JQ967326.1_Paraphysomonas_sp_9_JMS_2012KX100595.1_Paraphysomonas_sp_strain_JBM01 JQ967325.1_Paraphysomonas_sp_20_JMS_2012 KX100596.1_Paraphysomonas_sp_strain_9_20_F1KX100597.1_Paraphysomonas_sp_strain_PR26KA

JQ967323.1_Paraphysomonas_sp_18_JMS_2012JN934668.1_Paraphysomonas_sp_RCC1993_2 JQ967316.1_Paraphysomonas_sp_6_JMS_2012 x/y: MrBayes support: 50%/ 80% trim JQ967295.1_Paraphysomonas_sp_19_JMS_2012 JQ967310.1_Paraphysomonas_sp_10_JMS_2012 JQ967293.1_Paraphysomonas_sp_SW04

JQ967313.1_Paraphysomonas_sp_33_JMS_2012 JQ967305.1_Paraphysomonas_sp_17_JMS_2012 JQ967312.1_Paraphysomonas_sp_BZ5b a/b RAxML support: 50%/ 80% trim AF109324.1_Paraphysomonas_imperforata_strain_SR3 JQ967294.1_Paraphysomonas_sp_5_JMS_2012 JQ967311.1_Paraphysomonas_sp_32_JMS_2012 JQ967314.1_Paraphysomonas_sp_31_JMS_2012 JQ967315.1_Paraphysomonas_sp_SW02 EF165146.1_Lagynion_cf_ampullaceum_strain_CCMP2727 JQ967306.1_Paraphysomonas_sp_25_JMS_2012 JQ967309.1_Paraphysomonas_sp_1_JMS_2012 JQ967307.1_Paraphysomonas_sp_26_JMS_2012 JQ967308.1_Paraphysomonas_sp_8_JMS_2012

JQ967321.1_Paraphysomonas_sp_14_JMS_2012

JQ967320.1_Paraphysomonas_sp_13_JMS_2012

JQ967303.1_Paraphysomonas_sp_23_JMS_2012

JQ967304.1_Paraphysomonas_sp_28_JMS_2012

(ii) 16S tree JQ967301.1_Paraphysomonas_sp_27_JMS_2012

JQ967300.1_Paraphysomonas_sp_GMAL1

JQ967302.1_Paraphysomonas_sp_11_JMS_2012 CAMNT_0042911315_Pinguiococcus_pyrenoidosus_CCMP2078 EU004845.1_Uncultured_chrysophyte_isolate_DGGE_gel_band_E3794_27a JQ967298.1_Paraphysomonas_sp_24_JMS_2012 JQ967299.1_Paraphysomonas_sp_16_JMS_2012 CAMNT_0024607671_Mallomonas_Sp_Strain_CCMP3275

CAMNT_0006825303_Phaeomonas_parva_CCMP2877

CAMNT_0044163933_Synchroma_pusillum_CCMP3072 0.06

CAMNT_0024589761_Mallomonas_Sp_CCMP3275

LK391826.1_Ochromonas_sp_F933

LN735485.3_Chromulinaceae_sp_RCC902

LN735359.3_Ochromonas_sp_RCC2350

KJ877675.1_Ochromonas_sp_CCMP1393

CAMNT_0034033545_Ochromonas_sp_CCMP1393

CAMNT_0006990463_Ochromonas_sp_CCMP1899

1/1 59/89 CAMNT_0038045831_Ochromonas_sp_CCMP2298

CAMNT_0014075869_Ochromonas_sp_BG_1

CAMNT_0042114917_Chromulina_nebulosa_UTEXLB2642

CAMNT_0030329943_Dinobryon_sp_UTEXLB2267

0.04 (i) Depth 46212 751 4992 9006 1031 255 41 1 18 30

v9 v4 16S v9 v4 16S v9 v4 16S 16S Baffinella CCMP2293 Novel pelagophyte CCMP2097 Pavlovales CCMP2436 Ochro. 2298

MES/MXL DCM Surface

(ii) Size fraction

46212 751 4992 9006 1031 255 41 1 18 30

v9 v4 16S v9 v4 16S v9 v4 16S 16S Baffinella CCMP2293 Novel pelagophyte CCMP2097 Pavlovales CCMP2436 Ochro. 2298

0.2 to 1.6/ 3 0.8 to 3/5 3/5 to 20 20 to 180/200 180/ 200 to 2000 (i) Baffinella sp. CCMP2293 (ii) Novel pelagophyte CCMP2097

90 90

60 60

30 30

0 0 -200 -150 -100 -50 0 50 100 150 200 -200 -150 -100 -50 0 50 100 150 200

-30 -30

3 000 1 000 1 500 500 600 200 -60 150 -60 50

v9 0.8-2000 v4 0.8-2000 16S 0.8-2000 v9 3/5-20 v4 3/5-20 16S 3/5-20 v9 0.8-2000 v4 0.8-2000 16S 0.8-2000 v9 3/5-20 v4 3/5-20 16S 3/5-20 -90 -90

(iii) Pavlovales sp. CCMP2436 (iv) Ochromonas sp. CCMP2298

90 90

60 60

30 30

0 0 -200 -150 -100 -50 0 50 100 150 200 -200 -150 -100 -50 0 50 100 150 200

-30 -30

30 200 15 100 6 40 -60 2 -60 10

v4 0.8-2000 16S 0.8-2000 v9 3/5-20 v4 3/5-20 16S 0.8-2000 16S 0.8- 3/5 -90 -90 (i) 18S v4 ribotypes (ii) 18S v9 ribotypes (iii) 16S v4v5 ribotypes

30 30 30 25 25 25 20 20 20 15 15 15

Indian Ocean Indian Ocean Indian Ocean 10 10 10 5 5 5 0 0 0 -5 1 -5 1 -5 1 10 100 1000 10 100 1000 10 100 1000 Ocean Atlantic North OceanAtlantic North North Atlantic Ocean Atlantic North

South Pacific Ocean South Pacific Ocean South Pacific Ocean

(iv) 18S v9 ribotypes (v) 16S v4v5 ribotypes

30 30

25 25

20 20

15 15 Key

South Pacific Ocean South Pacific Ocean (i) Genomes phylPCA

1200

1000 Key 800 Chlorophytes 600 Chrysophyte relatives Cryptomonads

400 Diatoms Dictyochophytes Dinoflagellates

PC2:30.6% Pelagophyte200 CCMP2097 Pavlovales CCMP2436 Pelagophytes Haptophytes 0 Arctic species -1000 -500 0 500 1000 1500 2000 Ochromonas CCMP2298 Antarctic species -200 Other species

Baffinella CCMP2293 -400

-600 PC1: 36.9%

(ii) Transcriptomes phylPCA

400

Polarella glacialis Heterocapsa arctica

300

200

100

-200 Pavlovales CCMP2436 Ochromonas CCMP2298 Pelagophyte CCMP2097

-300

-400 Baffinella CCMP2293

Dictyochophyte CCMP2098 -500

-600 PC1: 71.9% A B 1 1

500 0.8 0,8

200

0.6 0,6 Bray-Curtis 100

PFAM PFAM BUSCO-normalised

50 0.4 0,4 Spearman

0.2 0,2

73 75 15 80 62 0 0 % BUSCO coverage Reference A Reference B Reference C Reference D Reference A Reference B Reference C Reference D Query library

1 1 Species 1 2 3 4 5 6 7 8 9 10 11 12 D

. .

C ...... Lineage 0.8 0,8 Chl Chl Chl Chl Chl Chl Hap Hap. Hap. Hap. Hap. Hap

...... 0.6 0,6 Library Gen Gen Gen Gen

Trans Trans Trans Trans Trans Trans Trans Trans

0,4

. . 0.4 Species Lineage Library Habitat NP NP FW Ant Ant

0,2 Other Other Other Other Arctic Arctic Arctic Arctic 0.2 1 Chlorophyte Genome Arctic A B

Genome comparisons Spearman Genomes Genome comparisons BUSCO Key ns

* Genomes ns

350 250 *** Arctic-Arctic ns 0.8 Arctic-Other 0.8 ** Other-Other 200 Arctic-Antarctic Antarctic-Antarctic0.9 0.6 0.6

250 150

* P < 0.05 BUSCO value BUSCO

0.7 PFAMs ** P < 0.01 PFAMs Spearman correlation -05 0.4 100 *** P < 10 0.4

0.5 shared

adjusted ns * 2000 ns BUSCO ** **** Spearman

Transcriptomes Transcriptomes Spearman nsns ns **** *******

BUSCO- **** **** *** *** 1.00 **** *** ns 10.9 ***ns * 1500°1500 *****

0.75 0.750.6 10001000 Curtis value − Spearman correlation Bray BUSCO value BUSCO 0.50 0.5 500 500 0.3

0.25 0 0.25 0 0.0 Arctic−Arctic Arctic−Other Other−Other Arctic−Antarctic Antarctic−Antarctic

Arctic−Arctic Arctic−Other Other−Other Arctic−Antarctic Antarctic−Antarctic Arctic−Arctic Arctic−Other Other−Other Arctic−Antarctic Antarctic−Antarctic i) PFAM convergence; Arctic genomes ii) PFAM convergence; Arctic transcriptomes

1,8 1.8 1,8 1.8

1,6 1.6 1,6 1.6

1.4 1,4 1,4 1.4

1.2 1,2

PFAMs 1,2 1.2

shared

1 0,6 0,8 1 1,2 1,4 1,6 1,8 1 0,6 0,8 1 1,2 1,4 1,6 corrected 0.6 0.8 1 1.2 1.4 1.6 1 0.6 0.8 1 1.2 1.4 1.6 1.8

BUSCO-correctedBray-Curtis enrichment

BUSCO-

Bray-Curtis enrichment Bray-Curtis enrichment 0.8

0,8 0,8 0.8 Novel pelagophyte CCMP2097

0.4 Arctic chlorophytes

0.4 0,4

0,4

Convergences involving diatoms All other Arctic convergences Transcriptome comparisons *** *Bray-Curtis index

** ****

**** *** 0.9 ******

0.60.6 Curtis value − Bray 0.30.3 Bray-Curtisvalue

0.00 Transcriptome comparisons Arctic−Arctic Arctic−Other Other−Other Arctic−Antarctic Antarctic−Antarctic ns BUSCO-nsnormalised PFAMs

ns ns 600 *** ****

ns **** Key

PFAMs

Arctic-Arctic 400400 Arctic-Other shared

Other-Other Arctic-Antarctic Antarctic-Antarctic adjusted BUSCO value BUSCO

200200 * P < 0.05 ** P < 0.01 BUSCO- *** P < 10-05 Genome comparisons

00 ns

Arctic−Arctic Arctic−Other Other**−Other Arctic−Antarctic Antarctic−Antarctic 1.5 **ns Spearman

*** **** *** **** ** 1.01 **

0.750.5 correlation Spearman correlation

0.50.0 Spearman

0.25−0.5 n=48 n=1235 n=7716 n=80 n=31 Arctic−Arctic Arctic−Other Other−Other Arctic−Antarctic Antarctic−Antarctic PF11999- ice-binding PF11028- DUF2723 PF10551- MULE transposase PF13879- KIAA1340

Ochromonas CCMP2298 Baffinella CCMP2293 Pavlovales CCMP2436

Genomes Novel pelagophyte CCMP2097

Attheya septentrionalis CCMP2084 Dictyochophyte CCMP2098 Polarella glacialis CCMP2088 Heterocapsa arctica CCMP445 Pavlovales CCMP2436 Pelagophyte CCMP2097

Transcriptomes -5 0 5 10 -20 0 20 40 60 80 100 120 -2 0 2 4 6 8 10 -2 0 2 4 6 8 10

PF01232- Mannitol dehydrogenase PF10233- DUF2465 PF13881- Ubiquitin Rad60 PF13424- Tetratricopeptide Ochromonas CCMP2298 Baffinella CCMP2293 Pavlovales CCMP2436 Genomes Novel pelagophyte CCMP2097

Pyramimonas CCMP2087 Micromonas CCMP2099

Frequency of expanded PFAM Frequency of contracted PFAM CAFE change value (i) metaT individual OTUs (i) Total metaT abundance 90 100% 80% 60 60% Other 40% Antarctic 30 20% 0% Arctic 0 -200 -150 -100 -50 0 50 100 150 200

-30 1E-03 (ii) metaG individual OTUs 5E-04 -60 100% 1E-04 80% -90 60% Other DCM, 0.8-3/5 DCM, 3-5/20 DCM, 20-180 DCM, 180-2000 40% SUR, 0.8-3/5 SUR, 3/5-20 SUR, 20-180 SUR, 180-2000 Antarctic 20% (ii) Total metaG abundance 0% Arctic 90

0 -200 -150 -100 -50 0 50 100 150 200

-30 1E-03 -60 5E-04 1E-04

-90 DCM, 0.8-3/5 DCM, 3-5/20 DCM, 20-180 DCM, 180-2000 SUR, 0.8-3/5 SUR, 3/5-20 SUR, 20-180 SUR, 180-2000 Biogeography Antarctic Antarctic Antarctic Antarctic Arctic Antarctic Antarctic Antarctic Arctic Arctic Arctic Antarctic Arctic Antarctic Arctic Arctic Arctic Arctic Arctic Arctic Hemiboreal