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SUPPLEMENT Neuropsychiatric Aspects of Parkinson's Disease: Focus on Insomnia, Daytime Sleepiness, and Psychosis

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SUPPLEMENT Neuropsychiatric Aspects of Parkinson's Disease: Focus on Insomnia, Daytime Sleepiness, and Psychosis MARCH 2008 VOL 13 — NO 3 — SUPPL 4 CNS SPECTRUMS THE INTERNATIONAL JOURNAL OF N E U R O PS YC H I AT R I C MEDICINE SUPPLEMENT Neuropsychiatric Aspects of Parkinson's Disease: Focus on Insomnia, Daytime Sleepiness, and Psychosis Introduction: Taking a Closer Look at Sleep Problems and Psychosis in Parkinson's Disease H.H. Fernandez Sleep Disorders Associated with Parkinson's Disease: Role of Dopamine, Epidemiology, and Clinical Scales of Assessment S.H. Mehta, J.C. Morgan, and K.D. Sethi Sleep Disturbances and Parkinson's Disease J.H. Friedman and R.P. Millman Psychosis in Parkinson's Disease: Phenomenology, Frequency, Risk Factors, and Current Understanding of Pathophysiologic Mechanisms G. Fenelon Course, Prognosis, and Management of Psychosis in Parkinson's Disease: Are Current Treatments Really Effective? L8. Zahodne and H.H. Fernandez Summary and Conclusions: What We Have Learned About Sleep Disorders and Psychosis After Nearly Two Centuries of Parkinson's Disease H.H. Fernandez Index Medicus/MEDUHE www.cnsspectrums.com Downloadedcitation: from CNS https://www.cambridge.org/core Spectr . IP address: 170.106.202.126, on 01 Oct 2021 at 21:55:00, subject to the Cambridge Core terms of use, available at https://www.cambridge.org/core/terms. https://doi.org/10.1017/S1092852900017235 EDITORS EDITORIAL ADVISORY BOARD EDITOR Mark S. George, MD Humberto Nicolini, MD, PhD Eric Hollander, MD Medical University of South Carolina National Mexican Institute of Psychiatry Mount Sinai School of Medicine Charleston, SC Mexico City, Mexico New York, NY Richard B. Lipton, MD Stefano Pallanti, MD, PhD Albert Einstein College of Medicine University of Florence INTERNATIONAL EDITOR Bronx, NY Florence, Italy Joseph Zohar, MD C. Warren Olanow, MD, FRCPC Katharine Phillips, MD Chaim Sheba Medical Center Mount Sinai School of Medicine Brown Medical School Tel-Hashomer, Israel New York, NY Providence, Rl Steven George Pavlakis, MD Harold A. Pincus, MD ASSOCIATE INTERNATIONAL EDITORS Maimonides Medical Center Columbia University EUROPE Brooklyn, NY New York, NY Donatella Marazziti, MD Stephen D. Silberstein, MD, FACP Scott L Rauch, MD University of Pisa Thomas Jefferson University Massachusetts General Hospital Pisa, Italy Philadelphia, PA Charlestown, MA Michael Trimble, MD, FRCP, FRPsych Alan F. Schatzberg, MD MID-ATLANTIC National Hospital for Neurology Stanford University School of Medicine DanJ. Stein, MD, PhD and Neurosurgery Stanford, CA University of Cape Town London, United Kingdom Cape Town, South Africa Thomas E. Schlaepfer, MD University of Bonn Bonn, Germany ASIA PSYCHIATRISTS Shigeto Yamawaki, MD, PhD Dennis S. Charney, MD Stephen M. Stahl, MD, PhD Hiroshima University School Mount Sinai School of Medicine University of California, San Diego of Medicine New York, NY LaJolla, CA Hiroshima, Japan Dwight L. Evans, MD Norman Sussman, MD University of Pennsylvania New York University Medical School CONTRIBUTING WRITERS Philadelphia, PA New York, NY Gilles Fenelon, MD, PhD Michael E. Those, MD Hubert H. Fernandez, MD, FAAN Siegfried Kasper, MD University of Vienna University of Pennsylvania School of Medicine Joseph H. Friedman, MD Philadelphia, PA Shyamal H. Mehta, MD, PhD Vienna, Austria Laura B. Zahodne Martin B. Keller, MD Madhukar H. Trivedi, MD Brown Medical School University of Texas Southwestern Medical FIELD EDITOR Providence, Rl Center Dallas, TX Michael Trimble, MD, FRCP, FRPsych Lorrin M. Koran, MD Stanford University School of Medicine Karen Dineen Wagner, MD, PhD COLUMNISTS Stanford, CA The University of Texas Medical Branch Galveston, TX Stephen M. Stahl, MD, PhD Yves Lecrubier, MD DanJ. Stein, MD, PhD Hopital de la Salpetriere Herman G.M. Westenberg, MD Paris, France University Hospital Utrecht NEUROLOGISTS Utrecht, The Netherlands Herbert Y. Meltzer, MD Mitchell F. Brin, MD Vanderbilt University Medical Center Stuart C. Yudofsky, MD University of California, Irvine Nashville, TN Baylor College of Medicine Irvine, CA Houston, TX Stuart A. Montgomery, MD Jeffrey L. Cummings, MD St. Mary's Hospital Medical School University of California, Los Angeles London, United Kingdom Los Angeles, CA Charles B. Nemeroff, MD, PhD Jerome Engel, Jr., MD, PhD Emory University School of Medicine University of California, Los Angeles Atlanta, GA Los Angeles, CA PUBLICATION STAFF CEO & PUBLISHER SENIOR ASSOCIATE EDITOR GRAPHIC DESIGNER Darren L. Brodeur Dena Croog—Primary Psychiatry Michael J. Vodilko VP, MANAGING EDITOR ASSOCIATE EDITOR CHIEF FINANCIAL OFFICER Christopher Naccari Lonnie Stoltzfoos—Psychiatry Weekly John Spano VP, SENIOR EDITOR ASSISTANT EDITORS STAFF ACCOUNTANT Deborah Hughes Carlos Perkins, Jr. Diana Tan VP, BUSINESS DEVELOPMENT Rebecca Zerzan ACCOUNTING INTERN Michael J. Stevinson Stephanie Spano SENIOR ACQUISITIONS EDITOR VP, HUMAN RESOURCES Lisa Arrington SALES & EVENT COORDINATOR Kimberly A. Brodeur Kimberly Schneider ACQUISITIONS EDITOR SENIOR GLOBAL Virginia Jackson OFFICE MANAGER ACCOUNT DIRECTOR Ronald Means EDITORIAL INTERNS Richard Ehrlich Jaime Cunningham RECEPTIONIST SENIOR ACCOUNT DIRECTOR Michelisa Lanche Kimberly Forbes Michelle Rushin CME DEVELOPMENT MANAGER INFORMATION TECHNOLOGY ACCOUNT MANAGER Shelley Wong Clint Bagwell Consulting Leah Kozak Lisa Pisicchio ASSISTANT—ENDURING MATERIALS SENIOR EDITORS Sonny Santana WEB INTERN Peter Cook—Psychiatry Weekly ART DIRECTOR Adam Schwartz Jose Ralat—CNS Spectrums Derek Oscarson CORPORATION COUNSEL Lawrence Ross, Esq. Bressler, Amery, and Ross Publishers of PRIMARY PSYCHIATRY' CNS SPECTRUMS" PsychiatryWeekly DownloadedCN Sfrom Spect https://www.cambridge.org/corer 13:3 (Suppl 4) . IP address: 170.106.202.126, on 01 Oct 2021 at 21:55:00, subject to the Cambridge Core terms of use, availableMarc hat 2008 https://www.cambridge.org/core/terms. https://doi.org/10.1017/S1092852900017235 Volume 13 CNS SPECTRUMS Number 3 (Suppl 4) The International Journal of Neuropsychiatric Medicine TABLE OF CONTENTS Neuropsychiatric Aspects of Parkinson's Disease: Focus on Insomnia, Daytime Sleepiness, and Psychosis Introduction: Taking a Closer 18 Psychosis in Parkinson's Look at Sleep Problems Disease: Phenomenology, and Psychosis in Frequency, Risk Factors, and Parkinson's Disease Current Understanding of the By Hubert H. Fernandez, MD, FAAN Pathophysiologic Mechanisms By Gilles Fenelon, MD, PhD Sleep Disorders Associated with Parkinson's Disease: 26 Course/ Prognosis, and Role of Dopamine, Management of Psychosis Epidemiology, and Clinical in Parkinson's Disease: Are Scales of Assessment Current Treatments Really By Shyamal H. Mehta MD, PhD, Effective? John C. Morgan MD, PhD, and By Laura B. Zahodne and Kapil D. Sethi, MD, FRCP Hubert H. Fernandez, MD, FAAN 12 Sleep Disturbances and 34 Summary and Conclusions: Parkinson's Disease What We Have Learned About By Joseph H. Friedman, MD, and Sleep Disorders and Psychosis Richard P. Millman, MD After Nearly Two Centuries of Parkinson's Disease By Hubert H. Fernandez, MD, FAAN Supported by funding from Kyowa Pharmaceuticals, Inc. Founded in 1996, CNS Spectrums is indexed in the Index Medicus data- base and is available on MEDLINE under the citation CNS Spectr. CNS Subscriber: Send address changes to CNS Spectrums c/o MMS,lnc, Spectrums is also the largest peer-reviewed, indexed neuropsychiatric 185 Hansen Court, Suite 1 10, Wood Dale, IL 60191-1150. journal in the United States. Advertisements in CNS Spectrums are accepted on the basis of adher- CNS Spectrums (ISSN 1092-8529) is published monthly by MBL ence to ethical medical standards, but acceptance does not imply Communications, Inc. 333 Hudson Street, 7th Floor, New York, NY 10013. endorsement by CNS Spectrums or the publisher. One-year subscription rates: domestic $120; foreign $195; in-training $85. CNS Spectrums is a registered trademark of CNS Spectrums, LLC, New For subscriptions: Tel: 212-328-0800; Fax: 212-328-0600; Web: www.cns- York, NY. Permission to reproduce articles in whole or part must be spectrums.com. Single issues: $15 - email [email protected]. obtained in writing from the publisher. BPA member. For editorial inquiries, please contact Deborah Hughes at [email protected]. For bulk reprints, please contact Christopher Naccari at [email protected]. Copyright ® 2008 by MBL Communications, Inc. All rights reserved. Printed in the United States. MISSION CNS Spectrums' editorial mission is to address relevant neuropsychiatric topics, including the prevalence of comorbid diseases among patients, and original research and reports that emphasize the profound diagnostic and physiologic connections made within the neu- rologic and psychiatric fields. The journal's goal is to serve as a resource to psychiatrists and neurologists seeking to understand and treat disturbances of cognition, emotion, and behavior as a direct consequence of central nervous system disease, illness, or trauma. This supplement to CNS Spectrums, as well as additional enduring materials and archived issues, is available at www.cnsspectrums.com. DownloadedCNS from Spect https://www.cambridge.org/corer 13:3 (Suppl 4) . IP address: 170.106.202.126, on 01 Oct 2021 at 21:55:00, subject to the Cambridge Core terms of use, availableMarch at 2008 https://www.cambridge.org/core/terms. https://doi.org/10.1017/S1092852900017235.
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