CNS SPECTRUMS the International Journal of Neuropsychiatric Medicine

August 2005 Volume 10 - Number 8 - Suppl 10 CNS SPECTRUMS The International Journal of Neuropsychiatric Medicine

ACADEMIC SUPPLEMENT Recent Advances in the Clinical Use of Atypical Antipsychotics

Introduction JJl. Lieberman

Mechanisms of Action of Atypical Antipsychotics F.Canas

Clinical Considerations in Selecting and Using Atypical Antipsychotics J. W. Newcomer

Index Med/cus/MEDLINE citation: CNS Spectr

Downloaded from https://www.cambridge.org/core. IP address: 170.106.203.244, on 04 Oct 2021 at 20:11:54, subject to the Cambridge Core terms of use, available at https://www.cambridge.org/core/terms. https://doi.org/10.1017/S109285290002513X August 2005 Volume 10 - Number 8 - Suppl 10 CNS SPECTRUMS The International Journal of Neuropsychiatric Medicine EDITOR BOARD OF ADVISORS Lorrin M. Koran, MD Jack M. Gorman, MD NEUROLOGISTS Stanford University School of Medicine Mount Sinai School of Medicine Mitchell F. Brin, MD Stanford, CA New York, NY University of California, Irvine Yves Lecrubier, MD Hopital de la Salpetriere ASSOCIATE AND FOUNDING EDITOR Irvine, CA Jeffrey L. Cummings, MD Paris, France Eric Hollander, MD University of California, Los Angeles HerbertY.Meltzer.MD Mount Sinai School of Medicine Los Angeles, CA Vanderbilt University Medical Center New York, NY Jerome Engel, Jr., MD, PhD Nashville, TN INTERNATIONAL EDITOR University of California, Los Angeles Stuart A. Montgomery, MD Los Angeles, CA St. Mary's Hospital Medical School Joseph Zohar, MD London, United Kingdom Chaim Sheba Medical Center MarkS. George, MD Medical University of South Carolina Charles B. Nemeroff, MD, PhD Tel-Hashomer, Israel Charleston, SC Emory University School of Medicine Atlanta, GA ASSOCIATE INTERNATIONAL EDITORS Deborah Hirtz.MD Humberto Nicolini, MD, PhD EUROPE National Institute of Neurological Disorders and Stroke, NIH National Mexican Institute of Psychiatry Donatella Marazziti, MD Rockville, MD Mexico City, Mexico University of Pisa Richard B. Upton, MD Stefano Pallanti, MD, PhD Pisa, Italy Albert Einstein College of Medicine University of Florence Bronx, NY Florence, Italy MID-ATLANTIC C. Warren Olanow, MD, FRCPC Katharine Phillips, MD Dan J. Stein, MD, PhD Mount Sinai School of Medicine Brown MedicalSchool University of Stellenbosch New York, NY Providence, Rl Tygerberg, South Africa Steven George Pavlakis, MD Harold A. Pincus, MD Maimonides Medical Center Western Psychiatric Institute & Clinic FAR EAST Brooklyn, NY RAND-Uniyersity of Pittsburgh Health Shigeto Yamawaki, MD, PhD Stephen D. Silberstein, MD, FACP Institute, Pittsburgh, PA Hiroshima University School Thomas Jefferson University Scott L.Rauch,MD of Medicine Philadelphia, PA Massachusetts General Hospital Hiroshima, Japan Charlestown, MA Michael Trimble, MD, FRCP, FRPsych Alan F. Schateberg, MD CONTRIBUTING AUTHORS National Hospital for Neurology Stanford University School of Medicine Fernando Canas, MD and Neurosurgery Stanford, CA London, United Kingdom Jeffrey A. Lieberman, MD Thomas E. Schlaepfer, MD John W. Newcomer, MD University of Bonn PSYCHIATRISTS Bonn, Germany SUPPLEMENT EDITOR Margaret Altemus, MD Stephen M. Stahl, MD, PhD Joseph Zohar, MD Cornell University Medical College University of California, San Diego New York, NY La Jolla, CA Dennis S. Charney, MD Norman Sussman, MD, DFAPA Mount Sinai School of Medicine New York University Medical School New York, NY New York, NY Dwight L. Evans, MD Karen Dineen Wagner, MD, PhD University of Pennsylvania The University of Texas Medical Branch Philadelphia, PA Galveston, Texas Siegfried Kasper, MD Herman G.M. Westenberg, MD University of Vienna University Hospital Utrecht Vienna, Austria Utrecht, The Netherlands Martin B. Keller, MD Stuart C. Yudofsky, MD Brown Medical School Baylor College of Medicine Providence, Rl Houston, TX

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Volume 10 - Number 8 (Suppl 10) CNS Spectrums - August 2005 Downloaded from https://www.cambridge.org/core. IP address: 170.106.203.244, on 04 Oct 2021 at 20:11:54, subject to the Cambridge Core terms of use, available at https://www.cambridge.org/core/terms. https://doi.org/10.1017/S109285290002513X CNS SPECTRUMS The International Journal of Neuropsychiatric Medicine Table of Contents

Founded in 1996, CNS Spectrums is an Index Medicus journal and is available on MEDLINE August 2005 under the citation CNS Spectr. It is available Volume 10 - Number 8 - Supplement 10 online at www.cnsspectrums.com. CNS Spec- trums is also distributed to all CINP members and is accredited for international CME by EACIC. Based on Proceedings From the 24th Congress of the CNS Spectrums (ISSN 1092-8529) is published Collegium Internationale Neuropsychopharmacologi- monthly by MBL Communications, Inc. 333 Hud- cum, held June 20-24, 2004, in Paris, France son Street, 7th Floor, New York, NY 10013.

One-year subscription rates: domestic $140; 4 Introduction—Recent Advances in die Clinical foreign $195; in-training $85. For subscrip- tions: Phone: 212-328-0800; Fax: 212-328-0600; Use of Atypical Antipsychotics Web: www.cnsspectrums.com.Postmaster: Send address changes to CNS Spectrums c/o By Jeffrey A. Lieberman, MD MMS, Inc, 185 Hanson Court, Suite 110, Wood Dale, IL 60191-1150.

5 Mechanisms of Action of Atypical Antipsychotics For editorial inquiries, please fax us at 212-328- 0600 or e-mail us at dh@mblcommunications. By Fernando Canas, MD com. For bulk reprint purchases, please contact: Kathleen J. Skae at [email protected].

12 Clinical Considerations in Selecting and Opinions and views expressed by authors are their own and do not necessarily reflect the Using Atypical Antipsychotics views of the publisher, MBL Communications, Inc., or the editorial advisory board. Advertise- By John W. Newcomer, MD ments in CNS Spectrums are accepted on the basis of adherence to ethical medical standards, but acceptance does not imply endorsement by CNS Spectrums or the publisher.

CNS Spectrums is a registered trademark of CNS Spectrums, LLC, New York, NY. Permission to reproduce articles in whole or part must be obtained in writing from the publisher.

BPA membership applied for July 2004. MBL

This academic supplement is sponsored by Pfizer Pharmaceuticals. Sponsorship of this review does not imply the sponsor's agreement with the views expressed herein.

Although every effort has been made to ensure that drug doses and other information are presented accurately in this publication, the ultimate responsibility rests with the prescribing physician. Neither the publisher, the sponsor, nor the authors can be held responsible for errors or for any consequences arising from the use of information contained herein. Readers are strongly urged to consult any relevant primary literature. No claims or endorsements are made for any drug or compound currently under clinical investigation. This supplement may contain information concerning a use or dosage schedule that has not be approved by the US Food and Drug Administration.