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From DNA Nanotechnology to Material Systems Engineering
PROGRESS REPORT DNA Nanotechnology www.advmat.de From DNA Nanotechnology to Material Systems Engineering Yong Hu and Christof M. Niemeyer* supramolecular networks. These devel- In the past 35 years, DNA nanotechnology has grown to a highly innovative opments have given rise to numerous and vibrant field of research at the interface of chemistry, materials science, so-called “DNA tiles” that can be used as biotechnology, and nanotechnology. Herein, a short summary of the state building blocks for the assembly through of research in various subdisciplines of DNA nanotechnology, ranging from sticky-end cohesion into discrete “finite” objects or periodic “infinite” 2D and 3D pure “structural DNA nanotechnology” over protein–DNA assemblies, periodic lattices.[4] However, since the nanoparticle-based DNA materials, and DNA polymers to DNA surface production of finite DNA nanostructures technology is given. The survey shows that these subdisciplines are growing from DNA tiles remained complicated,[5] ever closer together and suggests that this integration is essential in order to the development of the “scaffolded DNA initiate the next phase of development. With the increasing implementation origami” technique by Rothemund[6] is of machine-based approaches in microfluidics, robotics, and data-driven to be seen as an important milestone. Indeed, this method enabled the break- science, DNA-material systems will emerge that could be suitable for through of DNA nanotechology for the applications in sensor technology, photonics, as interfaces between technical fabrication of finite, programmable, and systems and living organisms, or for biomimetic fabrication processes. addressable nanostructures, thereby initi- ating a second wave of innovation in the field.[7] As discussed in Section 2, this set 1. -
Abstract Booklet
Abstract Booklet ONLINE EVENT 26th International Conference on DNA Computing and Molecular Programming 14–17 September 2020 IOP webinars for the physics community dna26.iopconfs.org/ Contents Committees 2 Sponsors 3 Proceedings 3 Programme 4 Poster programme 8 Keynote presentations 11 Contributed presentations 17 Poster sessions 48 1 Committees Chairs • Andrew Phillips, Microsoft Research, Cambridge, UK • Andrew Turberfield, Department of Physics, University of Oxford, UK Programme Chairs • Cody Geary, Interdisciplinary Nanoscience Centre, University of Aarhus, Denmark • Matthew Patitz, Department of Computer Science and Computer Engineering, University of Arkansas Steering Committee • Luca Cardelli, Computer Science, Oxford University, UK • Anne Condon (Chair), Computer Science, University of British Columbia, Canada • Masami Hagiya, Computer Science, University of Tokyo, Japan • Natasha Jonoska, Mathematics, University of Southern Florida, USA • Lila Kari, Computer Science, University of Waterloo, Canada • Chengde Mao, Chemistry, Purdue University, USA • Satoshi Murata, Robotics, Tohoku University, Japan • John H. Reif, Computer Science, Duke University, USA • Grzegorz Rozenberg, Computer Science, University of Leiden, The Netherlands • Rebecca Schulman, Chemical and Biomolecular Engineering, Johns Hopkins University, USA • Nadrian C. Seeman, Chemistry, New York University, USA • Friedrich Simmel, Physics, Technical University Munich, Germany • David Soloveichik, Electrical and Computer Engineering, The University of Texas at Austin, -
DNA Nanotechnology Meets Nanophotonics
DNA nanotechnology meets nanophotonics Na Liu 2nd Physics Institute, University of Stuttgart, Pfaffenwaldring 57, 70569 Stuttgart, Germany Max Planck Institute for Solid State Research, Heisenbergstrasse 1, 70569 Stuttgart, Germany Email: [email protected] Key words: DNA nanotechnology, nanophotonics, DNA origami, light matter interactions Call-out sentence: It will be very constructive, if more research funds become available to support young researchers with bold ideas and meanwhile allow for failures and contingent outcomes. The first time I heard the two terms ‘DNA nanotechnology’ and ‘nanophotonics’ mentioned together was from Paul Alivisatos, who delivered the Max Planck Lecture in Stuttgart, Germany, on a hot summer day in 2008. In his lecture, Paul showed how a plasmon ruler containing two metallic nanoparticles linked by a DNA strand could be used to monitor nanoscale distance changes and even the kinetics of single DNA hybridization events in real time, readily correlating nanoscale motion with optical feedback.1 Until this day, I still vividly remember my astonishment by the power and beauty of these two nanosciences, when rigorously combined together. In the past decades, DNA has been intensely studied and exploited in different research areas of nanoscience and nanotechnology. At first glance, DNA-based nanophotonics seems to deviate quite far from the original goal of Nadrian Seeman, the founder of DNA nanotechnology, who hoped to organize biological entities using DNA in high-resolution crystals. As a matter of fact, DNA-based nanophotonics does closely follow his central spirit. That is, apart from being a genetic material for inheritance, DNA is also an ideal material for building molecular devices. -
The Member Magazine of the American Society for Biochemistry and Molecular Biology CONTENTS
Vol. 13 / No. 5 / May 2014 THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY CONTENTS NEWS FEATURES PERSPECTIVES 2 14 18 PRESIDENT’S MESSAGE PROPAGATING POSSIBILITIES OPEN LETTER Good reads and the power of data Researcher tinkers with tree genetics On hindsight and gratitude 5 19 NEWS FROM THE HILL PROFESSIONAL DEVELOPMENT Making scientic research 11 19 Tips for Ruth L. Kirschstein training a priority for Congress grant applicants 21 e skills you need for 6 a career in science policy MEMBER UPDATE 22 Give credit where it is due ACS honors nine ASBMB members 24 7 EDUCATION JOURNAL NEWS 24 Reimagining the undergraduate 18 science course 12 27 ‘Creativity is in all – not a possession ASBMB NEWS of only a certain few’ 2014 annual meeting travel award winners 28 OUTREACH Yale Science Diplomats 28 31 LIPID NEWS Desperately seeking Sputnik for fundamental science 32 OPEN CHANNELS Reader comments 14 12 In our cover story, we learn about one research team’s eort to manipulate common trees to produce high-value commodities. MAY 2014 ASBMB TODAY 1 PRESIDENT’S MESSAGE calibration curves are much worse. tomy for breast cancer by surgeon perpetually changing landscape of is is particularly true for the local William Halsted and the implications breast cancer was beginning to tire THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY television forecasts: ey substantially of studies of its eectiveness. Moving him out. Trials, tables, and charts FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY Good reads and overpredict the probability of rain. past surgical treatments that focused had never been his forte; he was a is tendency gets at a key point. -
Suzanne Pfeffer
July 2010 ASBMB PreSidentiAl PriMer: Suzanne Pfeffer American Society for Biochemistry and Molecular Biology AAdjuvdjuvAAntnt IImmunothermmunotherAApypy ususIIngng KKrnrn70007000 KRN7000 (α-Galactosyl Ceramide) Avanti Number 867000 Supplier: Funakoshi Co. Ltd. Hepatic metastasis is a major clinical problem in cancer treatment. We examined antitumor ac- tivity of alpha-galactosylceramide (KRN7000) on mice with spontaneous liver metastases of re- ticulum cell sarcoma M5076 tumor cells (spontaneous metastasis model). In this model, all mice that were s.c. challenged with one million tumor cells developed a solid s.c. mass by day 7 and died of hepatic metastases. In the current study, we administered 100 microg/kg of KRN7000 to the model mice on days 7, 11, and 15. This treatment suppressed the growth of established liver metastases and resulted in the prolongation of survival time. Fluorescence-activated cell sorter analysis of phenotypes of spleen cells, hepatic lymphocytes, and regional lymph node cells around the s.c. tumor revealed that CD3+NK1.1+ (NKT) cells increased in hepatic lym- phocytes of the KRN7000-treated mice. Cytotoxic activity and IFN-gamma production of hepatic lymphocytes were augmented in comparison with those of spleen cells and regional LN cells. At the same time, interleukin (IL)-12 production of hepatic lymphocytes was markedly enhanced. Neutralization of IL-12 using a blocking monoclonal antibody diminished the prolonged survival time. These results showed that the in vivo antitumor effects of KRN7000 on spontaneous liver metastases were dependent on the endogenous IL-12 production, where NKT cells in the liver are suggested to be involved. Adjuvant immunotherapy using KRN7000 could be a promising modality for the prevention of postoperative liver metastases. -
Robert A. Alberty 1921–2014
Robert A. Alberty 1921–2014 A Biographical Memoir by Gordon G. Hammes and Carl Frieden ©2014 National Academy of Sciences. Any opinions expressed in this memoir are those of the authors and do not necessarily reflect the views of the National Academy of Sciences. ROBERT ARNOLD ALBERTY June 21, 1921–January 18, 2014 Elected to the NAS, 1965 Robert A. Alberty maintained an enthusiasm for science throughout his entire life. His presence at meetings was easily detectable, as he was blessed with an unmistak- able and booming voice that conveyed his latest scien- tific interests and above all his continual commitment to the science enterprise. Alberty directed this passion to thermodynamics and kinetics in particular, especially as applied to biological systems, and his research in these areas established a rich legacy for modern biophysical chemistry. He was a “triple-threat” scientist, excelling not only in research but also in teaching and university administration. Alberty (Bob to all who knew him) was born in Winfield, By Gordon G. Hammes Kansas, but when he was five years old his family moved and Carl Frieden to Lincoln, Nebraska. Even as a boy, he displayed a strong interest in science, exemplified by a basement chemistry laboratory and photographic dark room that he built in the family’s home. When he entered the University of Nebraska in 1939, Alberty had been planning a career as a chemical engineer, but then he discovered that this would require extensive coursework in drafting and surveying. Because he had already learned surveying from his grandfather, he saw no need to take college courses in the subject. -
Newsletter University of Wisconsin-Madison
NEWSLETTER UNIVERSITY OF WISCONSIN-MADISON For friends of the Department of Biochemistry at the University of Wisconsin–Madison Table of Contents From the Chair .............................................................. 3 Gene Regulation .....................................................20-21 Exciting Discoveries ...................................................4-6 In Memoriam ..............................................................21 Biochemistry Phase II ...................................................7 Remembering Ross Inman ..........................................22 Kamaluddin Ahmad Graduate Scholarship ...................8 RNA Maxi Group ........................................................23 Student Faculty Liaison Committee ..............................9 Department Alumnus: Dustin Maly ............................ 24 After Retirement - Bill Reznikoff .................................10 Department Alumnus: Jenifer (Bork) Miskowski ....... 25 New Faculty Profi le .....................................................11 Biochemistry Graduate Degrees .............................26-29 Celebrating Har Gobind Khorana ..........................12-13 Staff Departures ..........................................................30 Our Department in India .......................................14-15 From the Labs ........................................................31-53 Our Department in Uganda ........................................16 Contact Information ...................................................54 iGEM -
15/5/40 Liberal Arts and Sciences Chemistry Irwin C. Gunsalus Papers, 1877-1993 BIOGRAPHICAL NOTE Irwin C
15/5/40 Liberal Arts and Sciences Chemistry Irwin C. Gunsalus Papers, 1877-1993 BIOGRAPHICAL NOTE Irwin C. Gunsalus 1912 Born in South Dakota, son of Irwin Clyde and Anna Shea Gunsalus 1935 B.S. in Bacteriology, Cornell University 1937 M.S. in Bacteriology, Cornell University 1940 Ph.D. in Bacteriology, Cornell University 1940-44 Assistant Professor of Bacteriology, Cornell University 1944-46 Associate Professor of Bacteriology, Cornell University 1946-47 Professor of Bacteriology, Cornell University 1947-50 Professor of Bacteriology, Indiana University 1949 John Simon Guggenheim Fellow 1950-55 Professor of Microbiology, University of Illinois 1955-82 Professor of Biochemistry, University of Illinois 1955-66 Head of Division of Biochemistry, University of Illinois 1959 John Simon Guggenheim Fellow 1959-60 Research sabbatical, Institut Edmund de Rothchild, Paris 1962 Patent granted for lipoic acid 1965- Member of National Academy of Sciences 1968 John Simon Guggenheim Fellow 1972-76 Member Levis Faculty Center Board of Directors 1977-78 Research sabbatical, Institut Edmund de Rothchild, Paris 1973-75 President of Levis Faculty Center Board of Directors 1978-81 Chairman of National Academy of Sciences, Section of Biochemistry 1982- Professor of Biochemistry, Emeritus, University of Illinois 1984 Honorary Doctorate, Indiana University 15/5/40 2 Box Contents List Box Contents Box Number Biographical and Personal Biographical Materials, 1967-1995 1 Personal Finances, 1961-65 1-2 Publications, Studies and Reports Journals and Reports, 1955-68 -
DNA 7 - Seveth International Meeting on DNA Based Computers - Instruction for Authors
DNA 7 - Seveth International Meeting on DNA Based Computers - Instruction for Authors DNA7 Seventh International Meeting on DNA Based Computers June 10-13, 2001 Download this Document as .pdf | .doc | .rtf Introduction Biomolecular computing has emerged as a an interdisciplinary field that draws together molecular biology, chemistry, computer science and mathematics. Our knowledge of DNA nanotechnology and biomolecular computing increases exponentially with every passing year. The annual international meeting has been a forum where scientists with different backgrounds, yet sharing a common interest in biomolecular computing, meet and present their latest results. Continuing with this tradition, the 7th International Meeting on DNA Based Computers will focus on the current theoretical and experimental results with the greatest impact. Papers and poster presentations are sought in all areas that relate to computing with biomolecules including (but not limited to): algorithms and applications, models of biomolecular computation (using DNA and/or other molecules), analysis of laboratory techniques and theoretical models, error correction, sequence design, simulation software, DNA chemistry, DNA motifs, DNA devices, and computational processes in vivo. We particularly encourage papers and posters reporting experimental results. Instruction for Authors ● Each paper should include one address and e-mail address for all correspondence related to the submission. ● Each paper should contain an abstract stating the main results and their importance. ● We encourage document preparation in LaTex, but PostScript, pdf and MSWord files will also be accepted. For the final version of the document please follow the guidelines for the Springer-Verlag LNCS series at: http://www.springer.de/comp/lncs/authors.html ● The preferred format for submission is a .PDF, .PS or .RTF file or e-mailed to the chair of the program committee at: [email protected]. -
1993 Human Genome Program Report
Please address queries on this publication to: Human Genome Program U.S. Department of Energy Office of Health and Environmental Research ER-72 GTN Washington, DC 20585 301/903-6488, Fax: 301/903-8521 Internet: [email protected] Human Genome Management Information System Oak Ridge National Laboratory P.O. Box 2008 Oak Ridge, TN 37831-6050 615/576-6669, Fax: 615/574-9888 BITNET: bkq@ornlstc Internet: [email protected] This report has been reproduced directly frorn the best obtainable copy. Available to DOE and DOE contractors from the Office of Scientific and Technical Information; P.O. Box 62; Oak Ridge, TN 37831. Price information: 615/576-8401 . Available to the public from the National Technical Information Service; U.S. Department of Commerce; 5285 Port Royal Road; Springfield, VA 22161. DOE/ER-0611 P uman nome 1993 Program Report Date Published: March 1994 U.S. Department of Energy Office of Energy Research Office of Health and Environmental Research Washington, D.C. 20585 Preface he purpose of this report is to update the Human Genome 1991-92 Program Report T (DOE/ER-0544P, published June 1992) and provide new information on the DOE genome program to researchers, program managers, other government agencies, and the interested public. This FY 1993 supplement includes abstracts of 60 new or renewed projects and listings of 112 continuing and 28 completed projects. These two reports, taken together, present the most complete published view of the DOE Human Genome Program through FY 1993. Research is progressing rapidly toward the 15-year goals of mapping and sequencing the DNA of each of the 24 different human chromosomes. -
Wilfred A. Van Der Donk
WILFRED A. VAN DER DONK University of Illinois at Urbana-Champaign Department of Chemistry, 161 RAL Box 38-5 Urbana, IL 61801 Phone: (217) 244-5360; FAX: (217) 244-8533 [email protected] Date of birth April 21, 1966 US citizen since 2013 EDUCATION 1989 B.Sc & M.Sc, Leiden University, The Netherlands Thesis Advisor: Prof. Jan Reedijk Thesis Title: Model Complexes for Copper Metallo-Enzymes 1994 Ph.D., Rice University, Houston, Texas Thesis Advisor: Prof. Kevin Burgess Thesis Title: Transition Metal Catalyzed Hydroborations POSITIONS SINCE FINAL DEGREE 1994-1997 Postdoctoral Fellow, Massachusetts Institute of Technology, Cambridge, MA Advisor Prof. JoAnne Stubbe Project: Mechanistic Studies on Ribonucleotide Reductase 1997-2003 Assistant Professor, Department of Chemistry University of Illinois at Urbana-Champaign 2003-2005 Associate Professor, Department of Chemistry University of Illinois at Urbana-Champaign 2005-2008 William H. and Janet Lycan Professor of Chemistry University of Illinois at Urbana-Champaign 2008-present Richard E. Heckert Endowed Chair in Chemistry University of Illinois at Urbana-Champaign 2008-present Investigator, Howard Hughes Medical Institute 2007-present Professor, Institute for Genomic Biology University of Illinois at Urbana-Champaign FELLOWSHIPS AND AWARDS 1989 Cum Laude Masters Thesis, Leiden University 1989-1993 Robert A. Welch Predoctoral Fellowship 1991, 1994 Harry B. Weiser Scholarship for Excellence in Research (Rice University) 1994-1997 Postdoctoral Fellowship, Jane Coffin Childs Foundation for Medical Research 1997 Camille and Henry Dreyfus New Faculty Award 1998 Burroughs Wellcome New Investigator in the Pharmacological Sciences 1998 Research Innovation Award from the Research Corporation 1 1999 School of Chemical Sciences Teaching Award (U. Illinois) 1999 UIUC Research Board Beckman Award 1999 Arnold and Mabel Beckman Young Investigator Award 1999 3M Non-Tenured Faculty Award 2000 Cottrell Scholar of the Research Corporation 2001 Beckman Fellow, Center for Advanced Study, University of Illinois 2001 Alfred P. -
Single Molecule Based Nanoelectronics
Deanship of Graduate Studies AL-Quds University Single Molecule Based Nanoelectronics Ali Mohammed Kayed Atawneh M. Sc. Thesis Jerusalem-Palestine 1426 / 2006 Chapter one _______________________________________________________________ Introduction 1.1. Introduction Nanoscience is the study of phenomena and manipulating of materials at atomic, molecular and macromolecular scales, where nano-sciences are lead to a better understanding of properties of materials at the atomic level, or resulting from the reduction of dimensions down to the nanometer range. And many technologies are concerned with producing new industrial materials on nano-meter scale – one of these technologies is nanotechnology- but one of the problems facing nanotechnology actually physics, so physics is different on the nanometer scale, the properties of materials can behave differently and have new characteristics. Nanotechnologies are anew expression of a fundamental concept concerned with the development of tools for molecular electronics, that can be used first for measuring properties, then for assembling atoms and molecules to create new materials having superior properties useful in the fabrication of nano-electronic devices. So, nanotechnology includes both molecular electronics and nanoscale devices, where it is research's are aimed at building very small machines and electronics and constructing materials molecule-by-molecule and aggregates that can perform the basic functions of larger electronic components and assemble them into atomically precise molecular electronic devices (Joachim, Gimzewski, Aviram, 2000). Raw materials of nanotechnology include inorganic matter like metals and semiconductors, molecules like polymers and carbon nanotubes, and biological molecules like DNA and proteins. Devices that have dimension on a nanometer scale are called nanoelectronic devices; the use of nanoelectronic devices is interested for several reasons.