A Guide to the Archival Collection of the Robert Cook-Deegan Human
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f:EPARl'MENl' OF HEALm, EDUCATICN, AND WELFARE ruBLIC HFALTH SERVICE NATlCNAL INSTI'1'tTI'£S OF HFALTH RECCIo!BlNANT OOA MOLOCULE PRCGRAM ADVISORY CCMotITl'EE MINUT&S OF MEET:nl; JANUARY 15-16, 1977 'nle Recanbinant [IUl. Molecule Program Advisory COIIIllittee was convened for its seventh meeting at 9 a.m. on January 15, 1977 in the Courier-Emissary Room, Tower 1, Sheraton-Four AJti)assadors Hotel, Miami, Florida. Dr. DeWitt Stetten, Jr., (Chairman) Deputy Director for SCience, am Dr. Leon Jacobs, (Vice Chairman) Associate Director for Collaborative Research, NIH, presided. In accordance with Public Law 92-463 the meeting was open to the public. Committee members present were: Drs. Edward A. Adelberg~ Roy Curtiss. III: James E. Darnell, Jr.; Peter Day; Donald Helinski: David S. Bogness: Elizabeth M. Kutten John W. Littlefield: Emnette S. Redford: Wallace P. Rowe; Jane K. Setlow; John Spizizen; Waclaw Szybalski; Lelt>y Walters; and William J. Gartland, Jr., Executive Secretary. A Committee roster is attached. (Attachment I) The following ad hoc consultant to the Committee was present: Dr. Susan Gottesman, National Cancer lnsti tute, NIB. ttle following liaison representatives were present: Dr. John F. Fulkerson, U.S. Deparbnent of Agriculture Dr. Hermal Lewis, National Science FoundatiQrl Other National Institutes of Health staff present were: Dr. Emnett Barkley, ocr; Dr. Peter- Con:Uiff, Fogarty International Center; Dr. Daphne Kamely, NIGMS: Dr. John N.1tter, NIAID: Dr. Bernard Talbot, 00; am Dr. Rudolf Wanner, DRS. 2 others in attendance for all or part of the meeting were: Dr. Frederick Blattner, University of Wisconsin: n.... Harvey Faber, University of Wisconsin; Dr. -
1993 Human Genome Program Report
Please address queries on this publication to: Human Genome Program U.S. Department of Energy Office of Health and Environmental Research ER-72 GTN Washington, DC 20585 301/903-6488, Fax: 301/903-8521 Internet: [email protected] Human Genome Management Information System Oak Ridge National Laboratory P.O. Box 2008 Oak Ridge, TN 37831-6050 615/576-6669, Fax: 615/574-9888 BITNET: bkq@ornlstc Internet: [email protected] This report has been reproduced directly frorn the best obtainable copy. Available to DOE and DOE contractors from the Office of Scientific and Technical Information; P.O. Box 62; Oak Ridge, TN 37831. Price information: 615/576-8401 . Available to the public from the National Technical Information Service; U.S. Department of Commerce; 5285 Port Royal Road; Springfield, VA 22161. DOE/ER-0611 P uman nome 1993 Program Report Date Published: March 1994 U.S. Department of Energy Office of Energy Research Office of Health and Environmental Research Washington, D.C. 20585 Preface he purpose of this report is to update the Human Genome 1991-92 Program Report T (DOE/ER-0544P, published June 1992) and provide new information on the DOE genome program to researchers, program managers, other government agencies, and the interested public. This FY 1993 supplement includes abstracts of 60 new or renewed projects and listings of 112 continuing and 28 completed projects. These two reports, taken together, present the most complete published view of the DOE Human Genome Program through FY 1993. Research is progressing rapidly toward the 15-year goals of mapping and sequencing the DNA of each of the 24 different human chromosomes. -
Correspondence Occurrence
194 NATURE VOL. 226 APRIL I I 1970 where he began a very fruitful series of researches in made by the Public Health Service at the Taft Sanitary fungal antibiotics. Engineering Center in Cincinnati, Ohio, and by the Robertson succeeded Sir Ian Heilbron to the Heath Bureau of Occupational Health, Stato of California, Harrison Chair of Organic Chemistry at Liverpool in Berkeley, California, in which it was determined that 1933, a post he held until he retired at the age of sixty samples of mother's milk contained amounts of pesticide in October 1957. During this period he carried out a residues far in excess of the pesticide residues permitted brilliant series of investigations on the hydroxy-carbinol by FDA in cows' milk. Further, the study concludcd and heterocyclic oxygen compounds of natural occurrence that there were no ill effects on the babies as a result which included many of the non-nitrogenous bitter of the pesticide residue in the mother's milk." principles of plants, as well as a variety of fish poisons L6froth also says, "Man has not yet been exposed to the and insecticides. During the twenty-four years of hIs organochlorine pesticides for a full lifetime". However, occupancy of the Liverpool chair his output of original as Hayes' points out, "Time slips by so rapidly we tend work was prodigious and marked throughout by brilliance to forget that DDT has now been commercially available of perception and execution. Among his many triumphs for 20 years, and its military use is even longer .... I was the clarification of the chemistry of tho rotenone group, venture to say that in some sectors of Naples where DDT the insecticidal compounds of derris root, of usnic acid and was used so effectively to combat typhus in 1943 and 1944, of many complex colouring matters and pigments of the 20 years is a generation". -
Celebrating 40 Years of Rita Allen Foundation Scholars 1 PEOPLE Rita Allen Foundation Scholars: 1976–2016
TABLE OF CONTENTS ORIGINS From the President . 4 Exploration and Discovery: 40 Years of the Rita Allen Foundation Scholars Program . .5 Unexpected Connections: A Conversation with Arnold Levine . .6 SCIENTIFIC ADVISORY COMMITTEE Pioneering Pain Researcher Invests in Next Generation of Scholars: A Conversation with Kathleen Foley (1978) . .10 Douglas Fearon: Attacking Disease with Insights . .12 Jeffrey Macklis (1991): Making and Mending the Brain’s Machinery . .15 Gregory Hannon (2000): Tools for Tough Questions . .18 Joan Steitz, Carl Nathan (1984) and Charles Gilbert (1986) . 21 KEYNOTE SPEAKERS Robert Weinberg (1976): The Genesis of Cancer Genetics . .26 Thomas Jessell (1984): Linking Molecules to Perception and Motion . 29 Titia de Lange (1995): The Complex Puzzle of Chromosome Ends . .32 Andrew Fire (1989): The Resonance of Gene Silencing . 35 Yigong Shi (1999): Illuminating the Cell’s Critical Systems . .37 SCHOLAR PROFILES Tom Maniatis (1978): Mastering Methods and Exploring Molecular Mechanisms . 40 Bruce Stillman (1983): The Foundations of DNA Replication . .43 Luis Villarreal (1983): A Life in Viruses . .46 Gilbert Chu (1988): DNA Dreamer . .49 Jon Levine (1988): A Passion for Deciphering Pain . 52 Susan Dymecki (1999): Serotonin Circuit Master . 55 Hao Wu (2002): The Cellular Dimensions of Immunity . .58 Ajay Chawla (2003): Beyond Immunity . 61 Christopher Lima (2003): Structure Meets Function . 64 Laura Johnston (2004): How Life Shapes Up . .67 Senthil Muthuswamy (2004): Tackling Cancer in Three Dimensions . .70 David Sabatini (2004): Fueling Cell Growth . .73 David Tuveson (2004): Decoding a Cryptic Cancer . 76 Hilary Coller (2005): When Cells Sleep . .79 Diana Bautista (2010): An Itch for Knowledge . .82 David Prober (2010): Sleeping Like the Fishes . -
History of Genetics Book Collection Catalogue
History of Genetics Book Collection Catalogue Below is a list of the History of Genetics Book Collection held at the John Innes Centre, Norwich, UK. For all enquires please contact Mike Ambrose [email protected] +44(0)1603 450630 Collection List Symposium der Deutschen Gesellschaft fur Hygiene und Mikrobiologie Stuttgart Gustav Fischer 1978 A69516944 BOOK-HG HG œ.00 15/10/1996 5th international congress on tropical agriculture 28-31 July 1930 Brussels Imprimerie Industrielle et Finangiere 1930 A6645004483 œ.00 30/3/1994 7th International Chromosome Conference Oxford Oxford 1980 A32887511 BOOK-HG HG œ.00 20/2/1991 7th International Chromosome Conference Oxford Oxford 1980 A44688257 BOOK-HG HG œ.00 26/6/1992 17th international agricultural congress 1937 1937 A6646004482 œ.00 30/3/1994 19th century science a selection of original texts 155111165910402 œ14.95 13/2/2001 150 years of the State Nikitsky Botanical Garden bollection of scientific papers. vol.37 Moscow "Kolos" 1964 A41781244 BOOK-HG HG œ.00 15/10/1996 Haldane John Burdon Sanderson 1892-1964 A banned broadcast and other essays London Chatto and Windus 1946 A10697655 BOOK-HG HG œ.00 15/10/1996 Matsuura Hajime A bibliographical monograph on plant genetics (genic analysis) 1900-1929 Sapporo Hokkaido Imperial University 1933 A47059786 BOOK-HG HG œ.00 15/10/1996 Hoppe Alfred John A bibliography of the writings of Samuel Butler (author of "erewhon") and of writings about him with some letters from Samuel Butler to the Rev. F. G. Fleay, now first published London The Bookman's Journal -
EMBC Annual Report 2008
EMBO | EMBC annual report 2008 EUROPEAN MOLECULAR BIOLOGY ORGANIZATION | EUROPEAN MOLECULAR BIOLOGY CONFERENCE EMBO | EMBC table of contents introduction preface by Hermann Bujard, EMBO 5 preface by Tim Hunt, EMBO Council 8 preface by Peter Weisbeek & Krešimir Pavelić, EMBC 9 past & present timeline & brief history 12 EMBO | EMBC | EMBL aims 14 EMBO actions 2008 17 EMBC actions 2008 21 EMBO & EMBC programmes and activities fellowship programme 24 courses & workshops programme 25 young investigator programme 26 installation grants 27 science & society programme 28 EMBO activities The EMBO Journal 32 EMBO reports 33 Molecular Systems Biology 34 EMBO Molecular Medicine 35 journal subject categories 36 national science reviews 37 The EMBO Meeting 38 women in science 39 gold medal 40 award for communication in the life sciences 41 plenary lectures 42 information support & resources 43 public relations & communications 44 European Life Sciences Forum (ELSF) 45 ➔ 2 table of contents appendix EMBC delegates and advisers 48 EMBC scale of contributions 55 EMBO council members 2008 56 EMBO committee members & auditors 2008 57 EMBO council members 2009 58 EMBO committee members & auditors 2009 59 EMBO members elected in 2008 60 advisory editorial boards & senior editors 2008 72 long-term fellowship awards 2008 76 long-term fellowships: statistics 94 long-term fellowships 2008: geographical distribution 96 short-term fellowship awards 2008 98 short-term fellowships: statistics 116 short-term fellowships 2008: geographical distribution 118 young investigators -
Annual Report 2007-2008 2007-2008
EMBL Annual Report Annual Report 2007-2008 2007-2008 EMBL member states: Austria, Belgium, Croatia, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Israel, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland, United Kingdom. Associate member state: Australia AR0_07_08_tocRZ.qxp:ANNREPORT_05_06_1 02.06.2008 19:40 Uhr Seite 1 Annual Report 2007-2008 European Molecular Biology Laboratory AR0_07_08_tocRZ.qxp:ANNREPORT_05_06_1 02.06.2008 19:40 Uhr Seite 2 Contents The Director General’s Report . iv Foreword State of the Laboratory Integration of European Research Personnel and financial statistics Reviews of EMBL Scientific Units Scientific Report The catalogue of life . 2 A vast metabolism . 4 A new world order . 8 Roadmap to the future . 12 The years of plenty might be numbered . 16 Raising the standard . 20 Context is everything . 21 A solid basis for a future in science . 22 At the core… . 26 The future of our species . 28 Molecular managers . 32 A safari through the cell . 34 Finding the X-factor . 39 The seeds of change . 40 How does a shmoo schmooze? . 45 Push me, pull you . 46 Judging a gene by its cover . 51 Tale of the unexpected . 52 AR0_07_08_tocRZ.qxp:ANNREPORT_05_06_1 02.06.2008 19:40 Uhr Seite 3 In for the long haul . 57 Safety in numbers . 58 Cell-free supermodel . 62 Hooking up gene expression . 63 Through the kaleidoscope . 64 Into the crystal ball . 66 Keeping cell biology in shape . 70 Separating the wood from the trees . 75 3D vision . 76 The joy of SAXS . 80 Imaging the big picture . 84 Pole position . 88 Ringleaders get ready to rock . -
Meet Helke, the New Dean of Graduate Studies EMBL's Big In
44 EMBL April 2008 &cetera Newsletter of the European Molecular Biology Laboratory Meet Helke, the new Dean of Graduate Studies Helke Hillebrand, who has taken over as Dean of the EMBL International PhD Programme, is busy meeting as many of the student body as possible this month, both at Heidelberg and at the outstations. But she and outgoing Dean Anne Ephrussi found time to talk about the directions in which they hope to see the EMBL International PhD Programme going. “For me this role is the ideal combination of a scientific environment, communication with people, and a sense of doing something for education in a European context,” Helke says. page 2 EMBL’s big in Japan There’s been a series of Japanese-themed events and exchanges lately. Monterotondo group leader Cornelius Gross (far right) has just returned from a month spent sharing his mouse expertise with scientists in Tokyo, which stemmed from an earlier visit of National Institute of Basic Biology (NIBB) scientists to the out- station. EMBL’s collaboration agreement with the NIBB also led to the recent ‘Evolution of Epigenetic Regulation’ symposium at EMBL Heidelberg, and there was also a visit by a delegation from Osaka University in March. page 2 Would you really like to be 150 years old? Biochemist Cynthia Kenyon, one of the pioneers in research into ageing, is convinced that the world will soon be populated by lucid, wrinkle-free centenarians. After her Heidelberg Forum Biosciences and Society lecture in February, organised by EMBL, DKFZ, ZMBH and the university’s Medical Faculty, she found time for a chat about her brave new world, and about the research results that have persuaded her to change her lifestyle. -
Gene Pioneers: Donald Brown and Thomas Maniatis Win the 2012 Lasker~Koshland Special Achievement Award in Medical Science
Gene pioneers: Donald Brown and Thomas Maniatis win the 2012 Lasker~Koshland Special Achievement Award in Medical Science Kathryn Claiborn J Clin Invest. 2012;122(10):3383-3386. https://doi.org/10.1172/JCI66476. News The 2012 Lasker~Koshland Special Achievement Award in Medical Science recognizes Donald Brown (Carnegie Institute of Washington) and Thomas Maniatis (Columbia University) (Figure 1), two scientists whose career-long contributions were seminal to our understanding of what genes are and our ability to study and manipulate them, and whose commitment to mentorship have had tremendous impact on a generation of scientists. What is a gene? In the nineteenth century, an Austrian monk began a set of experiments in a small garden plot. Gregor Mendel’s detailed study of garden peas led him to understand that visible traits, such as the height or color of a plant, were determined by the combined inheritance of two physical particles from the two parent plants. Decades later, Theodor Boveri and Walter Sutton, analyzing meiotic cell divisions in grasshopper testes with the help of a microscope, hypothesized that Mendel’s hereditary factors — genes — could be carried on chromosomes. The groundwork was thus laid for a basic understanding of inheritance, but the question remained: what is a gene, exactly? Further understanding these entities — both their molecular makeup and their regulation — would require the dedication of innumerable scientific careers, as well as technical innovations that allowed the isolation and manipulation their sequences.Development -
From MRC-Cambridge to Madison, Wisconsin
C HA P TER 5 From MRC-Cambridge to Madison, Wisconsin William Dove and Alexandra Shedlovsky McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI Figure 5.1. Bill Dove. Figure 5.2. Alexandra Shedlovsky. PROLOGue – a STYLE OF DOING SCIENCE Our experience in the early 1960s as postdoctoral fellows in the MRC Unit for Molecular Biology led to our understanding the following principle: science is effectively driven by an idea when the seed is nourished by dialogue between con- trasting outlooks. We shall share our experiences that illustrate this ‘core principle’ 57 M ERIESM O AND C ONSEQUEN C E S by which the MRC unit thrived in that era. Since science does not function in a vacuum we include our perceptions of the cultural context that stimulated the growth of ideas through dialogue. This dialogue led to the remarkable edifice of molecular biology that emerged from the unit and its progeny around the world. Our comments are strictly matters of personal perception; however, Horace Judson’s Eighth Day of Creation gives a more global view of this and surrounding eras,1 while Sidney Altman wrote from a personal perspective of his experiences in the unit a decade later [‘RNA processing: a postdoc in a great laboratory’2]. Finally, the core principle is revealed in the essay written by the physical chemist John Platt [‘Strong Inference: Certain systematic methods of scientific thinking may produce much more rapid progress than others’3]. The messenger RNA experiments, the demonstration of the ‘triplet code’, and Marshall Nirenberg’s polyU encoding polyPhe experiment were all published by the middle of 1961. -
From MRC-Cambridge to Madison, Wisconsin
C HA P TER 5 From MRC-Cambridge to Madison, Wisconsin William Dove and Alexandra Shedlovsky McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI Figure 5.1. Bill Dove. Figure 5.2. Alexandra Shedlovsky. PROLOGue – a STYLE OF DOING SCIENCE Our experience in the early 1960s as postdoctoral fellows in the MRC Unit for Molecular Biology led to our understanding the following principle: science is effectively driven by an idea when the seed is nourished by dialogue between con- trasting outlooks. We shall share our experiences that illustrate this ‘core principle’ 57 MC.indd 57 07/05/2013 16:36:27 M E M ORIES AND C ONSEQUEN C ES by which the MRC unit thrived in that era. Since science does not function in a vacuum we include our perceptions of the cultural context that stimulated the growth of ideas through dialogue. This dialogue led to the remarkable edifice of molecular biology that emerged from the unit and its progeny around the world. Our comments are strictly matters of personal perception; however, Horace Judson’s Eighth Day of Creation gives a more global view of this and surrounding eras,1 while Sidney Altman wrote from a personal perspective of his experiences in the unit a decade later [‘RNA processing: a postdoc in a great laboratory’2]. Finally, the core principle is revealed in the essay written by the physical chemist John Platt [‘Strong Inference: Certain systematic methods of scientific thinking may produce much more rapid progress than others’3]. The messenger RNA experiments, the demonstration of the ‘triplet code’, and Marshall Nirenberg’s polyU encoding polyPhe experiment were all published by the middle of 1961. -
THE GENE WARS PT 6.Pdf 7.4 Mb
Epilogue T I HE JANUARY 1,1993, issue of Science announced that Francis S. JL Collins of the University of Michigan had agreed to direct the NIH genome program,1 confirming rumors that had persisted since midsum- mer. Collins agreed to join NIH on condition that a significant intramural genome research capacity be created on the NIH campus in Bethesda, Mary- land, so he would not have to give up active laboratory work. Collins agreed to make the move despite a cut in pay and the disruption of one of the most secure scientific empires in human genetics. Several members of his group, including himself, were funded by the Howard Hughes Medical Institute. This highly prestigious and financially stable base was buttressed by an NIH- funded genome research center linked to the University of Michigan. The University of Michigan combined one of the best state-supported universities with a medical school that had chosen soon after World War II to emphasize human genetics. Stanford geneticist David Botstein, for one, be- lieved that his unusually broad and deep training at Michigan—with exposure to excellent molecular biology and world-class human genetics, including pop- ulation genetics—gave him the requisite background to prepare him for the 1978 insight about the importance of a human genetic linkage map.2 Con- struction of just such a map helped spawn the revolution in human genetics that began in the 1980s. Why would Collins leave such an enviable position to direct a federal program? His answer: "Because there is only one human genome program. It will only happen once, and this is that moment in history.